ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Intramolecular
Cysteine 119 and cysteine 208
Cysteine 126 and cysteine 214
Cysteine 119 and cysteine 193
Cysteine 193 and cysteine 208
A redox-regulated disulphide may form within Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a between cysteines 119 and 208.

Details

Redox score ?
85
PDB code
6r99
Structure name
crystal structure of human cln protein 5 (ceroid lipofuscinosis neuronal protein 5)
Structure deposition date
2019-04-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A024R644
Residue number A
119
Residue number B
208
Peptide name
Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Ligandability

Cysteine 119 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a between cysteines 126 and 214.

Details

Redox score ?
84
PDB code
6r99
Structure name
crystal structure of human cln protein 5 (ceroid lipofuscinosis neuronal protein 5)
Structure deposition date
2019-04-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A024R644
Residue number A
126
Residue number B
214
Peptide name
Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Ligandability

Cysteine 126 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a between cysteines 119 and 193. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6r99
Structure name
crystal structure of human cln protein 5 (ceroid lipofuscinosis neuronal protein 5)
Structure deposition date
2019-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
14
% buried
nan
Peptide accession
A0A024R644
Residue number A
119
Residue number B
193
Peptide name
Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Ligandability

Cysteine 119 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a between cysteines 193 and 208. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
6r99
Structure name
crystal structure of human cln protein 5 (ceroid lipofuscinosis neuronal protein 5)
Structure deposition date
2019-04-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
14
% buried
nan
Peptide accession
A0A024R644
Residue number A
193
Residue number B
208
Peptide name
Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Ligandability

Cysteine 193 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 208 of Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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