Protein
Thiol Separation (Å)
HSE
Redox Score (%)
Ligandable
Loading...
Peroxiredoxin-2
2.0
56
86
PRDX2PRDX2P32119P32119cellredoxhomeostasiscellularresponsetooxidativestressdefenseresponsetotumorcellextrinsicapoptoticsignalingpathwayhydrogenperoxidecatabolicprocessleukocyteactivationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofTcelldifferentiationpositiveregulationofbloodcoagulationpositiveregulationofMAPKcascaderegulationofapoptoticprocessregulationofhydrogenperoxidemetabolicprocessremovalofsuperoxideradicalsrespiratoryburstinvolvedininflammatoryresponseresponsetolipopolysaccharideresponsetooxidativestressTcellhomeostasisTcellproliferationthymusdevelopment
Peroxiredoxin-4
2.1
48
87
✔
PDIA6PRDX4Q15084O08807proteinfoldingresponsetoendoplasmicreticulumstresscellredoxhomeostasisextracellularmatrixorganizationmalegonaddevelopmentnegativeregulationofmalegermcellproliferationpeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinmaturationbyproteinfoldingreactiveoxygenspeciesmetabolicprocessresponsetooxidativestressspermatogenesis
Peroxiredoxin-1
2.1
60
82
PRDX1PRDX1Q06830Q06830cellpopulationproliferationcellredoxhomeostasiscellularresponsetochemicalstresserythrocytehomeostasisfibroblastproliferationhydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsretinahomeostasisskeletalsystemdevelopment
Tropomyosin alpha-1 chain
2.2
54
84
TPM1TPM1P04692P04692actinfilamentcappingactinfilamentorganizationcardiacmusclecontractioncellularresponsetoreactiveoxygenspeciesinuteroembryonicdevelopmentmusclecontractionmusclefilamentslidingnegativeregulationofcellmigrationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofATP-dependentactivitypositiveregulationofcelladhesionpositiveregulationofheartratebyepinephrinepositiveregulationofstressfiberassemblyregulationofATP-dependentactivityregulationofcellshaperuffleorganizationsarcomereorganizationventricularcardiacmuscletissuemorphogenesiswoundhealing
Parkinson disease protein 7
3.0
74
70
✔
PARK7PARK7Q99497Q99497activationofproteinkinaseBactivityadultlocomotorybehaviorautophagycellulardetoxificationofaldehydecellulardetoxificationofmethylglyoxalcellularresponsetoglyoxalcellularresponsetohydrogenperoxidecellularresponsetooxidativestressdetectionofoxidativestressdetoxificationofcopperiondetoxificationofmercuryionDNArepairdopamineuptakeinvolvedinsynaptictransmissionglucosehomeostasisglutathionedeglycationglycolatebiosyntheticprocessglyoxalmetabolicprocessguaninedeglycationguaninedeglycationglyoxalremovalguaninedeglycationmethylglyoxalremovalhistonemodificationhydrogenperoxidemetabolicprocessinflammatoryresponseinsulinsecretionlactatebiosyntheticprocessmembranedepolarizationmembranehyperpolarizationmethylglyoxalcatabolicprocesstolactatemethylglyoxalmetabolicprocessmitochondrionorganizationnegativeregulationofapoptoticprocessnegativeregulationofcelldeathnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofdeath-inducingsignalingcomplexassemblynegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofhydrogenperoxide-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofnitrosativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofoxidativestress-inducedcelldeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinacetylationnegativeregulationofproteinbindingnegativeregulationofproteinexportfromnucleusnegativeregulationofproteinK48-linkeddeubiquitinationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofproteinsumoylationnegativeregulationofproteinubiquitinationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofTRAIL-activatedapoptoticsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitynegativeregulationofubiquitin-specificproteaseactivitypeptidyl-argininedeglycationpeptidyl-cysteinedeglycationpeptidyl-lysinedeglycationpositiveregulationofacuteinflammatoryresponsetoantigenicstimuluspositiveregulationofandrogenreceptoractivitypositiveregulationofautophagyofmitochondrionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofdopaminebiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofinterleukin-8productionpositiveregulationofL-dopabiosyntheticprocesspositiveregulationofL-dopadecarboxylaseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinonepositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofoxidativephosphorylationuncoupleractivitypositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofprotein-containingcomplexassemblypositiveregulationofpyrroline-5-carboxylatereductaseactivitypositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsuperoxidedismutaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftyrosine3-monooxygenaseactivityproteindeglycationglyoxalremovalproteindeglycationmethylglyoxalremovalproteindeglycosylationproteinstabilizationproteolysisRasproteinsignaltransductionregulationofandrogenreceptorsignalingpathwayregulationofhistoneacetylationregulationofhistoneubiquitinationregulationofinflammatoryresponseregulationofmitochondrialmembranepotentialregulationofneuronapoptoticprocessregulationofsupramolecularfiberorganizationresponsetooxidativestresssinglefertilization
Xaa-Pro dipeptidase
3.7
65
84
✔
PEPDPEPDP12955P12955aminoacidmetabolicprocesscollagencatabolicprocessproteolysis
Malonyl-CoA decarboxylase, mitochondrial
3.9
67
74
✔
DCMCDCMCO95822O95822acetyl-CoAbiosyntheticprocessacyl-CoAmetabolicprocessfattyacidbiosyntheticprocessfattyacidoxidationmalonyl-CoAcatabolicprocesspositiveregulationoffattyacidoxidationregulationoffattyacidbeta-oxidationregulationofglucosemetabolicprocessresponsetoischemia
LIM domain kinase 2
2.0
54
85
LIMK2LIMK2P53671P53671actincytoskeletonorganizationastralmicrotubuleorganizationcorneadevelopmentincamera-typeeyeestablishmentofvesiclelocalizationheaddevelopmentnegativeregulationofciliumassemblyphosphorylationpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationproteinphosphorylationspermatogenesis
3-ketoacyl-CoA thiolase, mitochondrial
4.3
79
70
✔
THIMTHIMP42765P42765cellularresponsetohypoxiacholesterolbiosyntheticprocessfattyacidbeta-oxidationnegativeregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessnegativeregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathway
Interleukin-1 receptor-associated kinase 4
5.5
72
56
IRAK4IRAK4Q9NWZ3Q9NWZ3cytokine-mediatedsignalingpathwayinnateimmuneresponseinterleukin-1-mediatedsignalingpathwayintracellularsignaltransductionJNKcascadeMyD88-dependenttoll-likereceptorsignalingpathwayneutrophilmediatedimmunityneutrophilmigrationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofsmoothmusclecellproliferationproteinphosphorylationtoll-likereceptor9signalingpathwaytoll-likereceptorsignalingpathway
Caspase-8
4.3
81
64
CASP8CASP8Q14790Q14790activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessangiogenesisapoptoticprocessapoptoticsignalingpathwayBcellactivationcellularresponsetomechanicalstimuluscellularresponsetoorganiccycliccompoundexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsheartdevelopmentmacrophagedifferentiationnaturalkillercellactivationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofnecroptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofmacrophagedifferentiationpositiveregulationofneurondeathpositiveregulationofproteolysisproteolysisproteolysisinvolvedinproteincatabolicprocesspyroptosisregulationofcytokineproductionregulationofinnateimmuneresponseregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetoantibioticresponsetocobaltionresponsetocoldresponsetoestradiolresponsetoethanolresponsetolipopolysaccharideresponsetotumornecrosisfactorselfproteolysissyncytiotrophoblastcelldifferentiationinvolvedinlabyrinthinelayerdevelopmentTcellactivationTRAIL-activatedapoptoticsignalingpathway
cGMP-dependent protein kinase 1
2.0
63
81
KGP1KGP1P00516P00516cGMP-mediatedsignalingcollateralsproutingdendritedevelopmentforebraindevelopmentnegativeregulationofplateletaggregationnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronmigrationproteinphosphorylationregulationofGTPaseactivityrelaxationofvascularassociatedsmoothmuscle
H-2D cell surface glycoprotein
1.7
84
82
Q31167Q31167Q31167Q31167antigenprocessingandpresentationimmuneresponse
Sodium channel protein type 4 subunit alpha
2.0
32
87
SCN4ASCN4AP35499P35499membranedepolarizationduringactionpotentialmusclecontractionneuronalactionpotentialregulationofiontransmembranetransportregulationofskeletalmusclecontractionbyactionpotentialsodiumiontransmembranetransportsodiumiontransport
Alpha-lactalbumin
1.7
74
87
LALBALALBAP00709P00709apoptoticprocesscell-cellsignalingdefenseresponsetobacteriumlactosebiosyntheticprocesssignaltransduction
Guided entry of tail-anchored proteins factor CAMLG
1.8
48
86
CAMLGCAMLGP49069P49069Bcellhomeostasisdefenseresponseepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationproteininsertionintoERmembraneproteinstabilizationreceptorrecyclingsignaltransductiontail-anchoredmembraneproteininsertionintoERmembranevesicle-mediatedtransport
V1-22 protein
1.8
93
81
Q5NV88Q5NV88Q5NV88Q5NV88
Angiotensin-converting enzyme
1.8
46
87
ACEACEQ59GY8Q59GY8agingamyloid-betametabolicprocessangiogenesisinvolvedincoronaryvascularmorphogenesisangiotensinmaturationanimalorganregenerationantigenprocessingandpresentationofpeptideantigenviaMHCclassIarachidonicacidsecretionbloodvesseldiametermaintenancebloodvesselremodelingbradykinincatabolicprocessbraindevelopmentcellproliferationinbonemarrowcellularresponsetoaldosteronecellularresponsetoglucosestimuluseatingbehaviorembryodevelopmentendinginbirthoregghatchingfemalepregnancyheartcontractionhematopoieticstemcelldifferentiationhormonecatabolicprocesshormonemetabolicprocesskidneydevelopmentlungalveolusdevelopmentmalegonaddevelopmentmononuclearcellproliferationnegativeregulationofcalciumionimportnegativeregulationofgapjunctionassemblynegativeregulationofgeneexpressionnegativeregulationofglucoseimportnegativeregulationofproteinbindingnegativeregulationofrenalsodiumexcretionneutrophilmediatedimmunitypeptidecatabolicprocesspositiveregulationofapoptoticprocesspositiveregulationofinflammatoryresponsepositiveregulationofneurogenesispositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofproteinbindingpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofsystemicarterialbloodpressurepositiveregulationofvasoconstrictionpost-transcriptionalregulationofgeneexpressionproteolysisregulationofangiotensinmetabolicprocessregulationofbloodpressureregulationofhematopoieticstemcellproliferationregulationofrenaloutputbyangiotensinregulationofsmoothmusclecellmigrationregulationofsynapticplasticityregulationofsystemicarterialbloodpressurebyrenin-angiotensinregulationofvasoconstrictionresponsetodexamethasoneresponsetohypoxiaresponsetolaminarfluidshearstressresponsetolipopolysaccharideresponsetonutrientlevelsresponsetothyroidhormoneresponsetoxenobioticstimulussensoryperceptionofpainspermatogenesissubstancePcatabolicprocessvasoconstriction
Receptor-type tyrosine-protein phosphatase F
1.8
83
81
PTPRFPTPRFA2A8L5A2A8L5cellmigrationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofcellpopulationproliferationnegativeregulationofcellprojectionorganizationnegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofneurotrophinTRKreceptorsignalingpathwaynegativeregulationofreceptorbindingnervoussystemdevelopmentneuronprojectionregenerationpeptidyl-tyrosinedephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofdendritemorphogenesispositiveregulationofneuronapoptoticprocessproteindephosphorylationregulationofaxonregenerationregulationofneuronprojectiondevelopmentregulationofpostsynapseorganizationregulationofsynapsestructureoractivitysynapticmembraneadhesion
Interleukin-1 receptor type 2
1.9
nan
92
IL1R2IL1R2P27930P27930immuneresponsenegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofinterleukin-1alphaproductionnegativeregulationofinterleukin-1-mediatedsignalingpathwaynegativeregulationofproteinprocessingproteinprocessing
Interferon alpha/beta receptor 1
1.8
65
87
INAR1INAR1P17181P17181cellularresponsetointerferon-alphacellularresponsetoviruscytokine-mediatedsignalingpathwaypositiveregulationofcellularrespirationreceptorsignalingpathwayviaJAK-STATresponsetolipopolysaccharideresponsetovirustypeIinterferon-mediatedsignalingpathway
Cation-independent mannose-6-phosphate receptor
2.0
50
89
MPRIMPRIP08169P08169lysosomaltransport
Low-density lipoprotein receptor
2.0
49
89
LDLRLDLRP01130P01130amyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessarterymorphogenesiscellularresponsetofattyacidcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolhomeostasischolesterolimportcholesterolmetabolicprocesscholesteroltransportendocytosishigh-densitylipoproteinparticleclearanceintestinalcholesterolabsorptionlipidmetabolicprocesslipoproteincatabolicprocesslong-termmemorylow-densitylipoproteinparticleclearancenegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofgeneexpressionnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationofmicroglialcellactivationnegativeregulationofproteinmetabolicprocessnegativeregulationofreceptorrecyclingphagocytosisphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationoflysosomalproteincatabolicprocesspositiveregulationoftriglyceridebiosyntheticprocessreceptor-mediatedendocytosisreceptor-mediatedendocytosisinvolvedincholesteroltransportregulationofcholesterolmetabolicprocessregulationofphosphatidylcholinecatabolicprocessregulationofproteinmetabolicprocessresponsetocaloricrestriction
Albumin
2.0
56
87
B3VHM9B3VHM9B3VHM9B3VHM9
Oxytocin receptor
1.9
64
85
OXYROXYRP30559P30559cellsurfacereceptorsignalingpathwaydigestivetractdevelopmenteatingbehaviorERK1andERK2cascadeestrouscyclefemalepregnancyGprotein-coupledreceptorsignalingpathwayheartdevelopmentlactationmaternalbehaviormaternalprocessinvolvedinparturitionmemorymusclecontractionnegativeregulationofgastricacidsecretionpositiveregulationofbloodpressurepositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofnorepinephrinesecretionpositiveregulationofpenileerectionpositiveregulationofsynapseassemblypositiveregulationofsynaptictransmissionGABAergicpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofuterinesmoothmusclecontractionpositiveregulationofvasoconstrictionregulationofsystemicarterialbloodpressurebyvasopressinresponsetoamphetamineresponsetoanoxiaresponsetococaineresponsetocytokineresponsetoestradiolresponsetopeptidehormoneresponsetoprogesteroneresponsetoxenobioticstimulussleepsocialbehaviorspermejaculationsucklingbehaviortelencephalondevelopment
Sperm-egg fusion protein Juno
2.0
50
86
JUNOJUNOA6ND01A6ND01celladhesionfusionofspermtoeggplasmamembraneinvolvedinsinglefertilizationsinglefertilizationsperm-eggrecognition
Suppressor of tumorigenicity 14 protein
2.0
nan
85
ST14ST14Q9Y5Y6Q9Y5Y6epithelialcellmorphogenesisinvolvedinplacentalbranchingkeratinocytedifferentiationneuraltubeclosureproteincatabolicprocessproteolysis
Lysophosphatidic acid receptor 1
1.9
35
88
LPAR1LPAR1Q92633Q92633activationofphospholipaseCactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayblebassemblycellchemotaxiscellularresponseto1-oleoyl-sn-glycerol3-phosphatecellularresponsetooxygenlevelscerebellumdevelopmentcorpuscallosumdevelopmentGprotein-coupledreceptorsignalingpathwaymyelinationnegativeregulationofcAMP-mediatedsignalingnegativeregulationofneuronprojectiondevelopmentneurogenesisoligodendrocytedevelopmentopticnervedevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofdendriticspinedevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofMAPKcascadepositiveregulationofRhoproteinsignaltransductionpositiveregulationofsmoothmusclecellchemotaxispositiveregulationofstressfiberassemblyregulationofcellshaperegulationofmetabolicprocessregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofsynapticvesiclecycle
MHC class I Mamu-A*02
1.9
76
84
Q30597Q30597Q30597Q30597antigenprocessingandpresentationimmuneresponse
Tumor necrosis factor receptor superfamily member 16
2.0
36
91
TNR16TNR16P07174P07174activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaxonguidancecellularglucosehomeostasiscellularresponsetoamyloid-betacellularresponsetooxidativestresscentralnervoussystemdevelopmentcircadianregulationofgeneexpressioncircadianrhythmdetectionoftemperaturestimulusdorsalaortadevelopmentfibroblastgrowthfactorreceptorsignalingpathwayfibroblastproliferationglucosehomeostasishairfollicledevelopmenthairfolliclemorphogenesisintracellularproteintransportnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofcellmigrationnegativeregulationofdendriticspinedevelopmentnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofhairfollicledevelopmentnegativeregulationofmitochondrialdepolarizationnegativeregulationofneuronapoptoticprocessnegativeregulationofneuronprojectiondevelopmentnervedevelopmentneuronapoptoticprocessodontogenesisofdentin-containingtoothpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoffibroblastproliferationpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofmyelinationpositiveregulationofneuralprecursorcellproliferationpositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofRhoproteinsignaltransductionpositiveregulationofsynaptictransmissioncholinergicpositiveregulationofsynaptictransmissionglutamatergicpresynapticmodulationofchemicalsynaptictransmissionregulationofcelldeathregulationofgeneexpressionregulationofreactiveoxygenspeciesmetabolicprocessresponsetolipopolysaccharideresponsetowoundingRhoproteinsignaltransductionsensoryperceptionofpainsignaltransductionskeletalmusclecelldifferentiationskindevelopment
Tumor necrosis factor receptor superfamily member 6B
1.9
49
90
TNF6BTNF6BO95407O95407apoptoticprocessnegativeregulationofapoptoticprocess
Ribonucleoprotein PTB-binding 2
1.9
51
89
✔
RAVR2RAVR2Q9HCJ3Q9HCJ3regulationofalternativemRNAsplicingviaspliceosome
Kallikrein-6
2.0
63
85
KLK6KLK6Q92876Q92876amyloidprecursorproteinmetabolicprocesscentralnervoussystemdevelopmentcollagencatabolicprocesshormonemetabolicprocessmyelinationpositiveregulationofGprotein-coupledreceptorsignalingpathwayproteinautoprocessingregulationofcelldifferentiationregulationofneuronprojectiondevelopmentresponsetowoundingtissueregeneration
N-acetylgalactosaminyltransferase 7
2.1
65
85
GALT7GALT7Q86SF2Q86SF2carbohydratemetabolicprocessO-glycanprocessingproteinO-linkedglycosylation
Retinal-specific phospholipid-transporting ATPase ABCA4
2.0
51
89
ABCA4ABCA4P78363P78363lipidtransportphospholipidtransfertomembranephospholipidtranslocationphotoreceptorcellmaintenancephototransductionvisiblelightretinalmetabolicprocessretinoidmetabolicprocesstransmembranetransportvisualperception
Voltage-dependent L-type calcium channel subunit alpha-1S
1.9
64
87
CAC1SCAC1SP07293P07293calciumiontransmembranetransportcellularresponsetocaffeinepositiveregulationofmusclecontractionregulationofryanodine-sensitivecalcium-releasechannelactivity
Protocadherin-15
1.9
43
89
PCD15PCD15Q99PJ1Q99PJ1actinfilamentorganizationadultwalkingbehaviorauditoryreceptorcellstereociliumorganizationcelladhesiondetectionofmechanicalstimulusinvolvedinequilibrioceptiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundequilibrioceptionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinnerearauditoryreceptorcelldifferentiationinnereardevelopmentinnerearreceptorcellstereociliumorganizationlocomotorybehaviormorphogenesisofanepitheliummulticellularorganismgrowthnon-motileciliumassemblyphotoreceptorcellmaintenanceresponsetocalciumionrightingreflexsensoryperceptionoflightstimulussensoryperceptionofsoundstartleresponsevisualperception
Insulin
1.9
nan
95
INSINSP01315P01315activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessglycoproteinbiosyntheticprocessinsulinreceptorsignalingpathwaylactatebiosyntheticprocesslipidbiosyntheticprocesslipoproteinbiosyntheticprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofDNAreplicationpositiveregulationoffattyacidbiosyntheticprocesspositiveregulationofglucoseimportpositiveregulationofglucosemetabolicprocesspositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipoproteinlipaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationtoplasmamembraneregulationoftransmembranetransporteractivityresponsetoL-argininevasodilationwoundhealing
cathelicidin-1-like
2.0
18
90
A0A2Y9FJE4A0A2Y9FJE4A0A2Y9FJE4A0A2Y9FJE4defenseresponsetobacterium
Tumor necrosis factor receptor superfamily member 3
2.0
nan
94
TNR3TNR3P36941P36941apoptoticprocesscellularresponsetomechanicalstimulushematopoieticorlymphoidorgandevelopmentimmuneresponsemyeloiddendriticcelldifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofJNKcascadesignaltransduction
Ly6/PLAUR domain-containing protein 3
2.0
69
85
LYPD3LYPD3O95274O95274cell-matrixadhesionnegativeregulationofsmoothmusclecellapoptoticprocess
Immunoglobulin kappa variable 1-33
1.9
92
81
KV133KV133P01594P01594adaptiveimmuneresponseimmuneresponse
Lactotransferrin
2.1
nan
89
TRFLTRFLQ9TUM0Q9TUM0antibacterialhumoralresponseantifungalhumoralresponsebonemorphogenesisinnateimmuneresponseinmucosaiontransportironionhomeostasisnegativeregulationofapoptoticprocessnegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationofosteoclastdevelopmentnegativeregulationofsingle-speciesbiofilmformationinoronhostorganismnegativeregulationoftumornecrosisfactor(ligand)superfamilymember11productionossificationpositiveregulationofbonemineralizationinvolvedinbonematurationpositiveregulationofchondrocyteproliferationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationproteolysisregulationofcytokineproductionregulationoftumornecrosisfactorproduction
Polypeptide N-acetylgalactosaminyltransferase 2
2.0
58
87
GALT2GALT2Q10471Q10471O-glycanprocessingproteinmaturationproteinO-linkedglycosylationproteinO-linkedglycosylationviaserineproteinO-linkedglycosylationviathreonine
Izumo sperm-egg fusion protein 1
1.9
44
85
IZUM1IZUM1Q8IYV9Q8IYV9celladhesionfusionofspermtoeggplasmamembraneinvolvedinsinglefertilizationheterotypiccell-celladhesionsinglefertilizationsperm-eggrecognition
Adhesion G-protein coupled receptor F1
1.9
69
86
AGRF1AGRF1Q5T601Q5T601adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaymemoryneuronprojectiondevelopmentpositiveregulationofCREBtranscriptionfactoractivitysynapseassembly
Platelet-derived growth factor subunit B
2.0
58
87
PDGFBPDGFBP01127P01127activationofproteinkinaseactivityactivationofproteinkinaseBactivitycellchemotaxiscellularresponsetogrowthfactorstimuluscellularresponsetomycophenolicacidcellularresponsetoplatelet-derivedgrowthfactorstimulusembryonicplacentadevelopmentheartdevelopmentinterleukin-18-mediatedsignalingpathwaymetanephricglomerularmesangialcelldevelopmentmonocytechemotaxisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationofmiRNAtranscriptionnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationnegativeregulationofproteinbindingnegativeregulationofvascularassociatedsmoothmusclecelldifferentiationparacrinesignalingpeptidyl-serinephosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcalciumionimportpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-substrateadhesionpositiveregulationofchemotaxispositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularfiltrationpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmetanephricmesenchymalcellmigrationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmitoticnucleardivisionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofvascularassociatedsmoothmusclecelldedifferentiationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseCsignalingproteinphosphorylationreactiveoxygenspeciesmetabolicprocessresponsetowounding
Albumin
2.0
54
86
F7BAY6F7BAY6F7BAY6F7BAY6
Interleukin-1 receptor type 1
2.0
41
88
IL1R1IL1R1P14778P14778cellsurfacereceptorsignalingpathwayimmuneresponseinflammatoryresponseinterleukin-1-mediatedsignalingpathwaypositiveregulationofinterleukin-1-mediatedsignalingpathwaypositiveregulationofneutrophilextravasationpositiveregulationofT-helper1cellcytokineproductionpositiveregulationoftypeIIinterferonproductionregulationofinflammatoryresponseresponsetointerleukin-1
Coagulation factor XI
2.1
42
87
FA11FA11P03951P03951bloodcoagulationbloodcoagulationintrinsicpathwayplasminogenactivationpositiveregulationoffibrinolysisproteolysiszymogenactivation
Mesencephalic astrocyte-derived neurotrophic factor
1.9
21
90
Q3TMX5Q3TMX5Q3TMX5Q3TMX5regulationofresponsetoendoplasmicreticulumstress
Arylsulfatase A
2.1
nan
90
SUMF1ARSAQ8NBK3P15289glycosphingolipidmetabolicprocesspost-translationalproteinmodificationproteinoxidationlipidmetabolicprocess
Albumin
2.0
59
87
G1U9S2G1U9S2G1U9S2G1U9S2cellularresponsetostarvationmaintenanceofmitochondrionlocationnegativeregulationofapoptoticprocess
Reversion-inducing cysteine-rich protein with Kazal motifs
2.0
60
85
RECKRECKQ9Z0J1Q9Z0J1bloodvesselmaturationembryoimplantationembryonicforelimbmorphogenesisextracellularmatrixorganizationnegativeregulationofcellmigrationnegativeregulationofmetalloendopeptidaseactivitypositiveregulationofcanonicalWntsignalingpathwayregulationofangiogenesisregulationofestablishmentofblood-brainbarriersproutingangiogenesis
Pro-adrenomedullin
2.0
30
87
ADMLADMLP35318P35318adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwayagingamylinreceptorsignalingpathwayandrogenmetabolicprocessanimalorganregenerationantibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebranchinginvolvedinlabyrinthinelayermorphogenesiscalciumionhomeostasiscAMP-mediatedsignalingcellpopulationproliferationdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdevelopmentalgrowthfemalepregnancyGprotein-coupledreceptorinternalizationheartdevelopmenthormonesecretioninflammatoryresponsenegativeregulationofcellpopulationproliferationnegativeregulationofvascularpermeabilitynegativeregulationofvasoconstrictionneuraltubeclosureneuronprojectionregenerationodontogenesisofdentin-containingtoothpositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofheartratepositiveregulationofprogesteronebiosyntheticprocesspositiveregulationofvasculogenesisreceptorinternalizationregulationofsystemicarterialbloodpressureregulationoftheforceofheartcontractionregulationofurinevolumeresponsetocoldresponsetoglucocorticoidresponsetohypoxiaresponsetoinsulinresponsetolipopolysaccharideresponsetostarvationresponsetowoundingsignaltransductionspongiotrophoblastlayerdevelopmentvascularassociatedsmoothmusclecelldevelopmentvasculogenesis
Coagulation factor IX
2.0
nan
92
FA9FA9P00740P00740bloodcoagulationbloodcoagulationintrinsicpathwayproteolysissequesteringofmetalionzymogenactivation
CMRF35-like molecule 8
2.0
60
85
CLM8CLM8Q9UGN4Q9UGN4celladhesionimmunesystemprocessnegativeregulationofactivationofJanuskinaseactivitynegativeregulationofBcellproliferationnegativeregulationofBcellreceptorsignalingpathwaynegativeregulationofeosinophilactivationnegativeregulationofeosinophilmigrationnegativeregulationoffibroblastproliferationnegativeregulationofMAPkinaseactivitynegativeregulationofmastcellactivationinvolvedinimmuneresponsenegativeregulationofmastcelldegranulationnegativeregulationofMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofneutrophilactivationnegativeregulationofNKTcellactivationnegativeregulationofphagocytosisengulfmentpositiveregulationofphosphoproteinphosphataseactivityregulationofTcellreceptorsignalingpathway
Secretory phospholipase A2 receptor
2.0
69
84
PLA2RPLA2RQ13018Q13018negativeregulationofarachidonicacidsecretionnegativeregulationofphospholipaseA2activityoxidativestress-inducedprematuresenescencepositiveregulationofarachidonicacidsecretionpositiveregulationofcytokineproductionpositiveregulationofDNAdamageresponsesignaltransductionbyp53classmediatorpositiveregulationofpodocyteapoptoticprocessreactiveoxygenspeciesmetabolicprocessreceptor-mediatedendocytosisreplicativesenescence
Immunoglobulin heavy constant mu
2.0
59
88
IGHMIGJP01871P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationglomerularfiltrationhumoralimmuneresponseimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasis
Liver carboxylesterase 1
2.0
62
84
EST1EST1Q9UK77Q9UK77cellularresponsetocholesterolcellularresponsetolow-densitylipoproteinparticlestimuluscholesterolbiosyntheticprocesscholesterolesterhydrolysisinvolvedincholesteroltransportcholesterolhomeostasischolesterolmetabolicprocessepithelialcelldifferentiationlipidcatabolicprocessmedium-chainfattyacidmetabolicprocessnegativeregulationofcholesterolstoragepositiveregulationofcholesteroleffluxpositiveregulationofcholesterolmetabolicprocessregulationofbileacidbiosyntheticprocessregulationofbileacidsecretionresponsetotoxicsubstancereversecholesteroltransport
Dickkopf-related protein 2
2.0
60
87
DKK2DKK2Q9QYZ8Q9QYZ8negativeregulationofcanonicalWntsignalingpathwaynegativeregulationofWntsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwayWntsignalingpathway
A disintegrin and metalloproteinase with thrombospondin motifs 13
2.0
52
88
ATS13ATS13Q76LX8Q76LX8cell-matrixadhesioncellularresponsetointerleukin-4cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonextracellularmatrixorganizationglycoproteinmetabolicprocessintegrin-mediatedsignalingpathwaypeptidecatabolicprocessplateletactivationproteincatabolicprocessproteinprocessingproteolysisresponsetoamineresponsetopotassiumionresponsetotoxicsubstance
Lectin-related NK cell receptor LY49G1
2.1
48
82
Q9JHV6Q9JHV6Q9JHV6Q9JHV6
Vasoactive intestinal polypeptide receptor 2
2.0
62
86
VIPR2VIPR2P41587P41587activationofadenylatecyclaseactivityadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwaycell-cellsignalingnegativeregulationofsmoothmusclecellproliferationsignaltransduction
Complement factor H
2.0
nan
90
CFAHCFAHP08603P08603complementactivationcomplementactivationalternativepathwayproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationofcomplement-dependentcytotoxicity
Roundabout homolog 2
2.0
78
83
ROBO2ROBO2Q9HCK4Q9HCK4aortadevelopmentaorticvalvemorphogenesisapoptoticprocessinvolvedinluteolysisaxonguidanceaxonmidlinechoicepointrecognitionbraindevelopmentcell-celladhesioncellularresponsetohormonestimuluscentralnervoussystemdevelopmentendocardialcushionformationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesmetanephrosdevelopmentnegativeregulationofnegativechemotaxisnegativeregulationofsynapseassemblyolfactorybulbinterneurondevelopmentoutflowtractseptummorphogenesispositiveregulationofaxonogenesispositiveregulationofNotchsignalingpathwayinvolvedinheartinductionpulmonaryvalvemorphogenesisretinalganglioncellaxonguidanceuretericbuddevelopmentventricularseptummorphogenesis
Immunoglobulin lambda constant 1
2.1
nan
92
IGLC1IGHG1P01842P01857adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationantibody-dependentcellularcytotoxicitycomplement-dependentcytotoxicity
Bone morphogenetic protein 2
2.0
66
86
BMP2BMP2P12643P12643ameloblastdifferentiationanimalorganmorphogenesisaorticvalvedevelopmentastrocytedifferentiationatrioventricularcanalmorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentBMPsignalingpathwayinvolvedinheartinductionbonedevelopmentbonemineralizationbranchinginvolvedinuretericbudmorphogenesiscardiacatriumformationcardiacepithelialtomesenchymaltransitioncardiacjellydevelopmentcardiacmusclecelldifferentiationcardiacmuscletissuemorphogenesiscardiocytedifferentiationcellfatecommitmentcell-cellsignalingcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundchondrocytedifferentiationcorticotropinhormonesecretingcelldifferentiationembryonichearttubeanterior/posteriorpatternspecificationendocardialcushionformationendocardialcushionmorphogenesisepithelialtomesenchymaltransitionheartdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnereardevelopmentmesenchymalcelldifferentiationmesenchymalcellproliferationinvolvedinuretericbuddevelopmentmesenchymedevelopmentnegativeregulationofaldosteronebiosyntheticprocessnegativeregulationofcalcium-independentcell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcortisolbiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofsmoothmusclecellproliferationnegativeregulationofsteroidbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofWntsignalingpathwayinvolvedinheartdevelopmentNotchsignalingpathwayodontogenesisofdentin-containingtoothosteoblastdifferentiationosteoclastdifferentiationpathway-restrictedSMADproteinphosphorylationpericardiumdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofastrocytedifferentiationpositiveregulationofbonemineralizationpositiveregulationofbonemineralizationinvolvedinbonematurationpositiveregulationofcartilagedevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofodontogenesispositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphataseactivitypositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationofWntsignalingpathwaypositiveregulationofWntsignalingpathwaybyBMPsignalingpathwayproteindestabilizationproteinphosphorylationproteoglycanmetabolicprocessregulationofDNA-templatedtranscriptionregulationofodontogenesisofdentin-containingtoothresponsetobacteriumresponsetohypoxiaskeletalsystemdevelopmentSMADproteinsignaltransductiontelencephalondevelopmenttelencephalonregionalizationthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIWntsignalingpathway
GPI transamidase component PIG-T
2.0
47
87
PIGTPIGTQ969N2Q969N2attachmentofGPIanchortoproteinneuronapoptoticprocessneurondifferentiation
Somatotropin
2.0
57
85
SOMASOMAP01241P01241animalorgandevelopmentbonematurationgrowthhormonereceptorsignalingpathwaypositiveregulationofactivationofJanuskinaseactivitypositiveregulationofglucosetransmembranetransportpositiveregulationofgrowthpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPkinaseactivitypositiveregulationofmulticellularorganismgrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftyrosinephosphorylationofSTATproteinreceptorsignalingpathwayviaJAK-STATresponsetoestradiolresponsetonutrientlevels
MHC class I antigen
2.2
79
81
F6IQS1F6IQS1F6IQS1F6IQS1
Tetraspanin-15
2.0
56
83
TSN15TSN15O95858O95858negativeregulationofNotchsignalingpathwayproteinlocalizationtoplasmamembraneproteinmaturation
Inactive dipeptidyl peptidase 10
2.0
61
86
DPP10DPP10Q8N608Q8N608positiveregulationofproteinlocalizationtoplasmamembraneproteinlocalizationtoplasmamembraneproteolysisregulationofpotassiumiontransmembranetransport
Chitinase-3-like protein 2
2.0
60
84
CH3L2CH3L2Q15782Q15782carbohydratemetabolicprocesschitincatabolicprocess
Ribitol 5-phosphate transferase FKRP
2.0
69
83
FKRPFKRPQ9H9S5Q9H9S5proteinO-linkedmannosylationproteinprocessingproteintetramerization
Butyrophilin subfamily 3 member A1
2.0
79
81
BT3A1BT3A1O00481O00481activatedTcellproliferationadaptiveimmuneresponsepositiveregulationofcytokineproductionpositiveregulationoftypeIIinterferonproductionregulationofcytokineproductionTcellreceptorsignalingpathway
Immunoglobulin lambda-1 light chain
2.0
35
85
IGL1IGL1P0DOX8P0DOX8adaptiveimmuneresponse
Zinc-alpha-2-glycoprotein
2.0
78
81
ZA2GZA2GP25311P25311antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbcelladhesiondetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertastenegativeregulationofcellpopulationproliferationretinahomeostasis
Deoxyribonuclease gamma
2.0
57
82
DNSL3DNSL3Q13609Q13609apoptoticDNAfragmentationDNAcatabolicprocessDNAcatabolicprocessendonucleolyticDNAmetabolicprocessneutrophilactivationinvolvedinimmuneresponseprogrammedcelldeathinvolvedincelldevelopmentregulationofacuteinflammatoryresponseregulationofneutrophilmediatedcytotoxicity
Vascular cell adhesion protein 1
2.0
47
89
VCAM1VCAM1P19320P19320acuteinflammatoryresponseagingaminemetabolicprocessBcelldifferentiationcalcium-mediatedsignalingusingintracellularcalciumsourcecardiacneurondifferentiationcelladhesioncellchemotaxiscell-celladhesioninresponsetoextracellularstimuluscell-matrixadhesioncellularresponsetoamyloid-betacellularresponsetotumornecrosisfactorcellularresponsetovascularendothelialgrowthfactorstimuluschronicinflammatoryresponseheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesheterotypiccell-celladhesioninnervationleukocytecell-celladhesionleukocytetetheringorrollingmembranetomembranedockingpositiveregulationofTcellproliferationresponsetoethanolresponsetohypoxiaresponsetoionizingradiationresponsetolipopolysaccharideresponsetonicotineresponsetonutrientresponsetozincion
Netrin-1
2.0
68
88
NET1NET1O09118O09118animalorganmorphogenesisanterior/posterioraxonguidanceapoptoticprocessaxonguidanceaxonogenesisBcellmediatedimmunityBcellproliferationCdc42proteinsignaltransductioncellpopulationproliferationcell-celladhesionchemorepulsionofaxondendritedevelopmentglialcellproliferationinnerearmorphogenesismammaryglanddevelopmentmammaryglandductmorphogenesismotorneuronaxonguidancemotorneuronmigrationnegativeregulationofaxonextensionneuronmigrationnuclearmigrationpositiveregulationofaxonextensionpositiveregulationofcellmotilitypositiveregulationofglialcellproliferationRasproteinsignaltransductionregulationofcellmigrationregulationofglialcellmigrationregulationofsynapseassemblysubstrate-dependentcellmigrationcellextensionTcellmediatedimmunitytissuedevelopment
Bone morphogenetic protein receptor type-1A
2.0
56
87
BMR1ABMR1AP36894P36894angiogenesisatrioventricularnodecelldevelopmentatrioventricularvalvedevelopmentBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentcardiacconductionsystemdevelopmentcardiacrightventriclemorphogenesiscellularresponsetoBMPstimuluscellularresponsetogrowthfactorstimuluscentralnervoussystemneurondifferentiationchondrocytedifferentiationdevelopmentalgrowthdorsalaortamorphogenesisdorsal/ventralaxisspecificationdorsal/ventralpatternformationectodermdevelopmentembryonicdigitmorphogenesisembryonicorgandevelopmentendocardialcushionformationendocardialcushionmorphogenesisepithelialcellproliferationfibrousringofheartmorphogenesisheartformationhindlimbmorphogenesisimmuneresponseinuteroembryonicdevelopmentlateralmesodermdevelopmentlungdevelopmentmesendodermdevelopmentmesodermformationmitralvalvemorphogenesisMullerianductregressionnegativeregulationofgeneexpressionnegativeregulationofmusclecelldifferentiationnegativeregulationofneurogenesisnegativeregulationofsmoothmusclecellmigrationneuralcrestcelldevelopmentneuralplatemediolateralregionalizationodontogenesisofdentin-containingtoothosteoblastdifferentiationoutflowtractmorphogenesisoutflowtractseptummorphogenesisparaxialmesodermstructuralorganizationpharyngealarcharterymorphogenesispituitaryglanddevelopmentpositiveregulationofbonemineralizationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacventricledevelopmentpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationofmesenchymalcellproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbeta2productionpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinphosphorylationregulationofcardiacmusclecellproliferationregulationofcellularsenescenceregulationoflateralmesodermalcellfatespecificationroofofmouthdevelopmentsomaticstemcellpopulationmaintenancesomitogenesistransforminggrowthfactorbetareceptorsignalingpathwaytricuspidvalvemorphogenesisventricularcompactmyocardiummorphogenesisventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesis
Mucin-2
2.0
nan
91
MUC2MUC2Q02817Q02817detoxificationofcopperionhost-mediatedregulationofintestinalmicrobiotacompositionmaintenanceofgastrointestinalepithelium
Vasoactive intestinal polypeptide receptor 1
2.0
57
85
VIPR1VIPR1P32241P32241adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerpositiveregulationofcellpopulationproliferation
Fibroblast growth factor receptor 2
2.0
68
85
FGFR2FGFR2P21803P21803angiogenesisanimalorganmorphogenesisapoptoticprocessaxonogenesisbonedevelopmentbonemineralizationbonemorphogenesisbranchelongationinvolvedinsalivaryglandmorphogenesisbranchinginvolvedinlabyrinthinelayermorphogenesisbranchinginvolvedinprostateglandmorphogenesisbranchinginvolvedinsalivaryglandmorphogenesisbranchingmorphogenesisofanervebudelongationinvolvedinlungbranchingcanonicalWntsignalingpathwaycardiacmusclecellproliferationcelldivisioncellfatecommitmentcellpopulationproliferationcell-cellsignalingcoronalsuturemorphogenesisdigestivetractdevelopmentembryoniccranialskeletonmorphogenesisembryonicdigestivetractmorphogenesisembryonicorgandevelopmentembryonicorganmorphogenesisembryonicpatternspecificationendodermaldigestivetractmorphogenesisepidermismorphogenesisepithelialcelldifferentiationepithelialcellproliferationepithelialcellproliferationinvolvedinsalivaryglandmorphogenesisepithelialtomesenchymaltransitionepithelialtubebranchinginvolvedinlungmorphogenesisERK1andERK2cascadefibroblastgrowthfactorreceptorsignalingpathwayfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinhemopoiesisfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinmammaryglandspecificationfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinnegativeregulationofapoptoticprocessinbonemarrowcellfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinorbitofrontalcortexdevelopmentfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinpositiveregulationofcellproliferationinbonemarrowglandmorphogenesishairfolliclemorphogenesisinuteroembryonicdevelopmentinnerearmorphogenesislacrimalglanddevelopmentlateralsproutingfromanepitheliumlensfibercelldevelopmentlimbbudformationlungalveolusdevelopmentlungdevelopmentlunglobemorphogenesislung-associatedmesenchymedevelopmentmammaryglandbudformationmembranousseptummorphogenesismesenchymalcelldifferentiationmesenchymalcelldifferentiationinvolvedinlungdevelopmentmesenchymalcellproliferationmesenchymalcellproliferationinvolvedinlungdevelopmentmidbraindevelopmentmitoticnucleardivisionmorphogenesisofembryonicepitheliumnegativeregulationofepithelialcellproliferationnegativeregulationofkeratinocyteproliferationnegativeregulationofmitoticnucleardivisionnegativeregulationoftranscriptionbyRNApolymeraseIIneuromuscularjunctiondevelopmentodontogenesisorbitofrontalcortexdevelopmentorgangrowthoticvesicleformationoutflowtractseptummorphogenesispeptidyl-tyrosinephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialcellproliferationinvolvedinlungmorphogenesispositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofphospholipaseactivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsomaticstemcelldivisionpositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurothelialcellproliferationpositiveregulationofWntsignalingpathwaypost-embryonicdevelopmentprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationprostateglandmorphogenesisproteinautophosphorylationpyramidalneurondevelopmentregulationofepithelialcellproliferationregulationofERK1andERK2cascaderegulationofmorphogenesisofabranchingstructureregulationofosteoblastproliferationregulationofsmoothmusclecelldifferentiationregulationofsmoothenedsignalingpathwayreproductivestructuredevelopmentsomaticstemcelldivisionsquamousbasalepithelialstemcelldifferentiationinvolvedinprostateglandacinusdevelopmentstemcelldifferentiationstemcellproliferationsynapticvesicletransporttransmembranereceptorproteintyrosinekinasesignalingpathwayuretericbuddevelopmenturothelialcellproliferationvasculogenesisinvolvedincoronaryvascularmorphogenesisventricularcardiacmuscletissuemorphogenesisventricularzoneneuroblastdivision
C-type lectin domain family 10 member A
2.1
50
86
CLC10CLC10Q8IUN9Q8IUN9adaptiveimmuneresponseendocytosisinnateimmuneresponse
Probable G-protein coupled receptor 158
2.0
47
91
GP158GP158Q5T848Q5T848proteinlocalizationtoplasmamembrane
Low-density lipoprotein receptor-related protein 8
2.0
57
88
LRP8LRP8Q14114Q14114ammongyrusdevelopmentcellularresponsetocholesterolcellularresponsetogrowthfactorstimuluschemicalsynaptictransmissioncytokine-mediatedsignalingpathwaydendritemorphogenesisendocytosislayerformationincerebralcortexlipidmetabolicprocessmodulationofchemicalsynaptictransmissionpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofdendritedevelopmentpositiveregulationofdendriticspinemorphogenesispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteintyrosinekinaseactivityproteolysisreelin-mediatedsignalingpathwayregulationofapoptoticprocessregulationofinnateimmuneresponseresponsetoxenobioticstimulusretinoidmetabolicprocesssignaltransductionventralspinalcorddevelopment
Kremen protein 1
2.0
66
86
KREM1KREM1Q96MU8Q96MU8apoptoticprocesscellcommunicationlimbdevelopmentnegativeregulationofaxonregenerationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofossificationregulationofcanonicalWntsignalingpathwayWntsignalingpathway
Leukocyte cell-derived chemotaxin-2
2.0
46
82
LECT2LECT2O14960O14960chemotaxisskeletalsystemdevelopment
R-spondin-2
2.0
51
90
RSPO2RSPO2Q8BFU0Q8BFU0bonemineralizationcanonicalWntsignalingpathwaydopaminergicneurondifferentiationembryonicforelimbmorphogenesisembryonichindlimbmorphogenesisepithelialtubebranchinginvolvedinlungmorphogenesislimbdevelopmentlunggrowthnegativeregulationofodontogenesisofdentin-containingtoothosteoblastdifferentiationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofWntsignalingpathwaytracheacartilagemorphogenesis
GDNF family receptor alpha-3
2.0
58
88
GFRA3GFRA3O60609O60609nervoussystemdevelopmentneuronmigrationperipheralnervoussystemdevelopmentsignaltransductionsympatheticnervoussystemdevelopment
Ig-like domain-containing protein
2.1
87
81
Q6PJG0Q6PJG0Q6PJG0Q6PJG0
Mannan-binding lectin serine protease 2
2.0
nan
89
MASP2MASP2Q9JJS8Q9JJS8cellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationcomplementactivationclassicalpathwaycomplementactivationlectinpathwaypositiveregulationofopsonizationproteolysis
Prolactin receptor
2.0
72
83
PRLRPRLRP16471P16471activationofJanuskinaseactivityactivationoftransmembranereceptorproteintyrosinekinaseactivitycellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscytokine-mediatedsignalingpathwayembryoimplantationlactationlocalizationmammaryglandalveolusdevelopmentmammaryglandepithelialcelldifferentiationnegativeregulationofapoptoticprocessoncostatin-M-mediatedsignalingpathwaypositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofproteinautophosphorylationprostateglandgrowthreceptorsignalingpathwayviaJAK-STATregulationofcelladhesionregulationofepithelialcelldifferentiationresponsetobacteriumsteroidbiosyntheticprocess
Complement component C8 alpha chain
2.0
nan
93
CO8ACO8AP07357P07357complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisimmuneresponsepositiveregulationofimmuneresponse
HLA class I histocompatibility antigen, B alpha chain
2.1
81
83
HLABHLABQ31610Q31610adaptiveimmuneresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-independentdefenseresponsedetectionofbacteriumimmuneresponseinnateimmuneresponsepositiveregulationofTcellmediatedcytotoxicityprotectionfromnaturalkillercellmediatedcytotoxicityregulationofdendriticcelldifferentiationregulationofinterleukin-12productionregulationofinterleukin-6productionregulationofTcellanergy
Neuropilin and tolloid-like protein 2
2.0
nan
89
NETO2NETO2C6K2K4C6K2K4neurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofpostsynapticneurotransmitterreceptoractivity
FAD-linked sulfhydryl oxidase ALR
2.0
nan
89
ALRALRQ63042Q63042cellularresponsetoactinomycinDcellularresponsetolipopolysaccharidecellularresponsetotoxicsubstancecellularresponsetotumornecrosisfactorliverdevelopmentliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofoxidativestress-inducedneurondeathpositiveregulationofDNAbiosyntheticprocessresponsetolipopolysaccharide
Toll-like receptor 4
2.0
nan
90
TLR4TLR4Q9QUK6Q9QUK6activationofinnateimmuneresponseactivationofNF-kappaB-inducingkinaseactivityastrocytedevelopmentBcellproliferationBcellproliferationinvolvedinimmuneresponsecellularresponsetoamyloid-betacellularresponsetolipopolysaccharidecellularresponsetolipoteichoicacidcellularresponsetomechanicalstimuluscellularresponsetooxidisedlow-densitylipoproteinparticlestimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetotypeIIinterferondefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdetectionoflipopolysaccharidedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainERK1andERK2cascadeI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationinflammatoryresponseinnateimmuneresponseinnateimmuneresponse-activatingsignalingpathwayintestinalepithelialstructuremaintenanceJNKcascadeleukotrienemetabolicprocesslipopolysaccharide-mediatedsignalingpathwaylymphocyteproliferationmacrophageactivationmastcellactivationMHCclassIIbiosyntheticprocessmicroglialcellactivationMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofcold-inducedthermogenesisnegativeregulationofERK1andERK2cascadenegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-23productionnegativeregulationofinterleukin-6productionnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionnitricoxidebiosyntheticprocessnitricoxideproductioninvolvedininflammatoryresponsenucleotide-bindingoligomerizationdomaincontaining1signalingpathwaynucleotide-bindingoligomerizationdomaincontaining2signalingpathwayphagocytosispositiveregulationofapoptoticprocesspositiveregulationofBcellproliferationpositiveregulationofcellularresponsetomacrophagecolony-stimulatingfactorstimuluspositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofchemokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-1productionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationoflymphocyteproliferationpositiveregulationofmacrophageactivationpositiveregulationofmacrophagecytokineproductionpositiveregulationofMAPkinaseactivitypositiveregulationofmatrixmetallopeptidasesecretionpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofnucleotide-bindingoligomerizationdomaincontaining1signalingpathwaypositiveregulationofnucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofplateletactivationpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofstress-activatedMAPKcascadepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionregulationofdendriticcellcytokineproductionregulationofinflammatoryresponseregulationofsensoryperceptionofpainregulationoftumornecrosisfactorproductionresponsetobacteriumresponsetoethanolresponsetofattyacidresponsetolipopolysaccharideresponsetooxidativestressstress-activatedMAPKcascadetoll-likereceptor4signalingpathwaytoll-likereceptorsignalingpathwayTRIF-dependenttoll-likereceptorsignalingpathwaywoundhealinginvolvedininflammatoryresponse
Polypeptide N-acetylgalactosaminyltransferase 4
2.0
60
85
GALT4GALT4Q8N4A0Q8N4A0O-glycanprocessingproteinO-linkedglycosylationproteinO-linkedglycosylationviaserineproteinO-linkedglycosylationviathreonine
Lactoperoxidase
2.0
58
86
L8ICE9L8ICE9L8ICE9L8ICE9defenseresponsetobacteriumdetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteresponsetooxidativestress
Complement component C7
2.0
34
90
CO7CO7P10643P10643complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysispositiveregulationofimmuneresponse
Serine protease inhibitor Kazal-type 1
2.0
nan
87
ISK1ISK1P00995P00995cellularresponsetopeptidehormonestimulusnegativeregulationofcalciumionimportnegativeregulationofnitricoxidemediatedsignaltransductionnegativeregulationofpeptidyl-tyrosinephosphorylationnegativeregulationofserine-typeendopeptidaseactivitynitricoxidemediatedsignaltransductionpeptidyl-tyrosinephosphorylationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofepithelialcellproliferationpositiveregulationofpancreaticjuicesecretionpositiveregulationofpeptidehormonesecretionregulationofacrosomereactionregulationofstore-operatedcalciumentryresponsetoethanolresponsetonutrientlevelsspermcapacitation
Sodium channel subunit beta-2
2.0
29
87
SCN2BSCN2BO60939O60939cardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionchemicalsynaptictransmissiongeneexpressionmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityresponsetoheatresponsetopyrethroidsodiumiontransmembranetransport
Roundabout homolog 1
2.0
72
85
ROBO1ROBO1Q9Y6N7Q9Y6N7activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaortadevelopmentaorticvalvemorphogenesisaxonmidlinechoicepointrecognitioncelladhesioncellmigrationinvolvedinsproutingangiogenesischemorepulsioninvolvedinpostnatalolfactorybulbinterneuronmigrationendocardialcushionformationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofcellmigrationnegativeregulationofchemokine-mediatedsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofmammaryglandepithelialcellproliferationnegativeregulationofnegativechemotaxisnervoussystemdevelopmentoutflowtractseptummorphogenesispositiveregulationofaxonogenesispositiveregulationofgeneexpressionpositiveregulationofMAPkinaseactivitypositiveregulationofNotchsignalingpathwayinvolvedinheartinductionpositiveregulationofRhoproteinsignaltransductionpositiveregulationofvascularendothelialgrowthfactorsignalingpathwaypulmonaryvalvemorphogenesisRoundaboutsignalingpathwayventricularseptummorphogenesis
Urokinase plasminogen activator surface receptor
2.0
45
89
UPARUPARQ03405Q03405bloodcoagulationchemotaxisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofDNAbindingpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofhomotypiccell-celladhesionpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofcelladhesionregulationoffibrinolysisregulationofplasminogenactivationregulationofproteolysissignaltransductionurokinaseplasminogenactivatorsignalingpathway
Neurotrophin-4
2.0
77
85
NTF4NTF4P34130P34130adultlocomotorybehaviorepidermisdevelopmentganglionmothercellfatedeterminationinnervationlong-termmemorymechanoreceptordifferentiationmemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwayneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofpeptidyl-serinephosphorylationregulationofneurondifferentiationsensoryorganboundaryspecificationtastebuddevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Afamin
2.1
39
88
AFAMAFAMP43652P43652proteinstabilizationproteintransportwithinextracellularregionvitamintransport
Relaxin receptor 2
2.0
29
88
RXFP2RXFP2Q8WXD0Q8WXD0activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwaymalegonaddevelopment
Tumor necrosis factor ligand superfamily member 14
2.0
76
84
✔
TNF14TNF14O43557O43557apoptoticprocesscellularresponsetomechanicalstimulusimmuneresponsepositiveregulationofmyoblastdifferentiationpositiveregulationofmyoblastfusionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofTcellchemotaxissignaltransductionTcellactivationTcellchemotaxisTcellcostimulationTcellhomeostasisTcellproliferation
Interleukin-18-binding protein
2.1
nan
85
I18BPI18BPO95998O95998cellularresponsetohydrogenperoxidecellularresponsetotumornecrosisfactorresponsetolipopolysaccharideT-helper1typeimmuneresponse
Angiotensin-converting enzyme
2.0
53
82
F6V9L3F6V9L3F6V9L3F6V9L3proteolysis
Mucin-2
2.5
nan
94
A0A0G2JR65A0A0G2JR65A0A0G2JR65A0A0G2JR65
Vitamin K-dependent protein C
2.0
nan
92
PROCPROCP04070P04070bloodcoagulationnegativeregulationofapoptoticprocessnegativeregulationofbloodcoagulationnegativeregulationofcoagulationnegativeregulationofinflammatoryresponsepositiveregulationofestablishmentofendothelialbarrierproteolysis
MHC class I antigen
2.0
86
80
Q8WLS4Q8WLS4Q8WLS4Q8WLS4
Histocompatibility 2, M region locus 3
2.0
74
83
Q31093Q31093Q31093Q31093alpha-betaTcellactivationinvolvedinimmuneresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentdefenseresponsetobacteriumnitricoxidebiosyntheticprocesspositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftypeIIinterferonproductionresponsetomoleculeofbacterialorigin
Insulin-like growth factor 1 receptor
2.0
nan
94
IGF1RIGF1RQ60751Q60751adrenalglanddevelopmentamyloid-betaclearanceanimalorganmorphogenesisaxonogenesisbraindevelopmentcellularresponsetoamyloid-betacellularresponsetoglucosestimuluscellularresponsetoinsulinstimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimuluscerebellumdevelopmentdendriticspinemaintenanceepidermisdevelopmentestablishmentofcellpolarityestrouscycleexocrinepancreasdevelopmentglucosehomeostasisimmuneresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaymalesexdeterminationmammaryglanddevelopmentMAPKcascademitoticnucleardivisionnegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofhepatocyteapoptoticprocessnegativeregulationofMAPKcascadenegativeregulationofmusclecellapoptoticprocessnegativeregulationofproteinkinaseBsignalingneuronprojectiondevelopmentpeptidyl-tyrosineautophosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytokinesispositiveregulationofdevelopmentalgrowthpositiveregulationofDNAmetabolicprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmeioticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsteroidhormonebiosyntheticprocesspostsynapticmodulationofchemicalsynaptictransmissionprostateglandepitheliummorphogenesisproteinautophosphorylationproteinkinaseBsignalingproteinphosphorylationregulationofJNKcascaderesponsetoethanolresponsetoL-glutamatetranscytosistransmembranereceptorproteintyrosinekinasesignalingpathway
Ectonucleoside triphosphate diphosphohydrolase 2
2.1
46
89
Q5RJP4Q5RJP4Q5RJP4Q5RJP4
Serine protease inhibitor Kazal-type 6
2.0
nan
87
ISK6ISK6Q6UWN8Q6UWN8celldifferentiationcentralnervoussystemdevelopmentnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofserine-typepeptidaseactivity
Serotransferrin
2.0
nan
88
Q06AH7Q06AH7Q06AH7Q06AH7cellularironionhomeostasisironiontransport
GDNF family receptor alpha-like
2.0
54
88
GFRALGFRALQ6UXV0Q6UXV0glialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentpositiveregulationofMAPKcascadepositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcessstress-activatedproteinkinasesignalingcascade
Testis-expressed protein 101
2.0
48
87
TX101TX101Q9BY14Q9BY14bindingofspermtozonapellucidafertilizationflagellatedspermmotilityregulationofflagellatedspermmotility
Interleukin-18 receptor accessory protein
2.0
nan
90
I18RAI18RAO95256O95256cellpopulationproliferationcellularresponsetohydrogenperoxideimmuneresponseinflammatoryresponseinterleukin-18-mediatedsignalingpathwayneutrophilactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofNF-kappaBtranscriptionfactoractivity
Complement component C8 beta chain
2.0
nan
90
CO8BCO8BP07358P07358complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisimmuneresponsepositiveregulationofimmuneresponse
Platelet glycoprotein Ib beta chain
2.0
46
89
GP1BBGP1BBP13224P13224bloodcoagulationintrinsicpathwaycelladhesioncellsurfacereceptorsignalingpathwaymegakaryocytedevelopmentplateletactivationpositiveregulationofplateletactivationreleaseofsequesteredcalciumionintocytosol
IGL@ protein
2.0
29
87
Q6PIK1Q6PIK1Q6PIK1Q6PIK1
Insulin-like growth factor I
2.0
52
87
IGF1IGF1P01343P01343activationofproteinkinaseBactivitybonemineralizationinvolvedinbonematurationcellactivationcellpopulationproliferationcellularresponsetoamyloid-betaepithelialtomesenchymaltransitionERK1andERK2cascadeglycolatemetabolicprocessinsulin-likegrowthfactorreceptorsignalingpathwaymusclehypertrophymuscleorgandevelopmentmyoblastdifferentiationmyoblastproliferationmyotubecelldevelopmentnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofinterleukin-1betaproductionnegativeregulationofneuroinflammatoryresponsenegativeregulationofoocytedevelopmentnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessphosphatidylinositol3-kinasesignalingphosphatidylinositol-mediatedsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinsecretionpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationoftrophectodermalcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinkinaseBsignalingproteinstabilizationproteoglycanbiosyntheticprocessRasproteinsignaltransductionregulationofgeneexpressionregulationofproteinphosphorylationresponsetoheatsignaltransductionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationskeletalsystemdevelopmentwoundhealing
Neuroblastoma suppressor of tumorigenicity 1
2.0
32
88
NBL1NBL1P41271P41271animalorganmorphogenesisdeterminationofdorsalidentitynegativeregulationofBMPsignalingpathwaynegativeregulationofmonocytechemotaxisnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofneurondifferentiationsequesteringofBMPfromreceptorviaBMPbindingsequesteringofBMPinextracellularmatrix
MHC class I antigen
2.0
80
83
A0A6M6CC39A0A6M6CC39A0A6M6CC39A0A6M6CC39
Plasma kallikrein
2.0
50
87
KLKB1KLKB1P03952P03952bloodcoagulationbloodcoagulationintrinsicpathwayFactorXIIactivationfibrinolysisplasminogenactivationpositiveregulationoffibrinolysisproteolysiszymogenactivation
Group IIE secretory phospholipase A2
2.0
51
86
PA2GEPA2GEQ9NZK7Q9NZK7arachidonicacidsecretioninflammatoryresponselipidcatabolicprocesslow-densitylipoproteinparticleremodelingphosphatidylcholinemetabolicprocessphosphatidylglycerolmetabolicprocessphospholipidmetabolicprocess
Kallikrein-10
2.0
53
87
KLK10KLK10O43240O43240cellcycleproteolysis
C-type mannose receptor 2
2.0
60
86
MRC2MRC2Q9UBG0Q9UBG0collagencatabolicprocessendocytosisosteoblastdifferentiation
CD160 antigen
2.0
64
84
BY55BY55O95971O95971adaptiveimmuneresponseangiogenesisdefenseresponsetoGram-negativebacteriuminnateimmuneresponsemucosalimmuneresponsenegativeregulationofadaptiveimmunememoryresponsenegativeregulationofangiogenesisnegativeregulationofCD4-positivealpha-betaTcellcostimulationnegativeregulationofTcellreceptorsignalingpathwayphosphatidylinositol3-kinasesignalingpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofnaturalkillercellcytokineproductionpositiveregulationofnaturalkillercelldegranulationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedimmuneresponsetotumorcellpositiveregulationoftypeIIinterferonproductionTcellcostimulation
Disintegrin and metalloproteinase domain-containing protein 10
2.0
56
86
ADA10ADA10Q10741Q10741adherensjunctionorganizationamyloidprecursorproteincatabolicprocesscochleadevelopmentconstitutiveproteinectodomainproteolysisepidermalgrowthfactorreceptorligandmaturationinuteroembryonicdevelopmentmembraneproteinectodomainproteolysismonocyteactivationnegativeregulationofcelladhesionnegativeregulationofgeneexpressionNotchsignalingpathwayporecomplexassemblypositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofTcellchemotaxispostsynapseorganizationproteincatabolicprocessatpostsynapseproteinphosphorylationproteinprocessingregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofNotchsignalingpathwayregulationofpostsynapseorganizationregulationofvasculaturedevelopmentresponsetotumornecrosisfactortoxintransport
Tumor necrosis factor receptor superfamily member 21
2.1
65
90
TNR21TNR21O75509O75509adaptiveimmuneresponseapoptoticprocessaxonalfasciculationBcellapoptoticprocesscellularresponsetotumornecrosisfactorhumoralimmuneresponsemyelinationnegativeregulationofBcellproliferationnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-13productionnegativeregulationofinterleukin-5productionnegativeregulationofmyelinationnegativeregulationofTcellproliferationneuronapoptoticprocessoligodendrocyteapoptoticprocessregulationofoligodendrocytedifferentiationTcellreceptorsignalingpathway
Legumain
2.0
58
85
LGMNLGMNQ99538Q99538activationofcysteine-typeendopeptidaseactivityantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIassociativelearningcellularresponsetoamyloid-betacellularresponsetocalciumioncellularresponsetohepatocytegrowthfactorstimulusdendriticspineorganizationmemorynegativeregulationofERBBsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofmulticellularorganismgrowthnegativeregulationofneuronapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellchemotaxispositiveregulationoflong-termsynapticpotentiationpositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxisproteolysisproteolysisinvolvedinproteincatabolicprocessreceptorcatabolicprocessrenalsystemprocessresponsetoacidicpHselfproteolysisvacuolarproteinprocessingvitaminDmetabolicprocess
Chymotrypsin-C
2.1
nan
85
CTRCCTRCQ99895Q99895cellularcalciumionhomeostasisproteolysis
CD302 antigen
2.0
66
84
CD302CD302Q8IX05Q8IX05phagocytosis
Complement component C6
2.0
nan
91
CO6CO6P13671P13671complementactivationcomplementactivationclassicalpathwaycytolysisinuteroembryonicdevelopmentinnateimmuneresponsepositiveregulationofimmuneresponse
Acid-sensing ion channel 2
2.1
50
86
ASIC2ASIC2Q16515Q16515centralnervoussystemdevelopmentchemicalsynaptictransmissiondetectionofmechanicalstimulusinvolvedinsensoryperceptionestablishmentoflocalizationincellinorganiccationtransmembranetransportnegativeregulationofapoptoticprocessperipheralnervoussystemdevelopmentphototransductionpositiveregulationofsynapseassemblyproteinlocalizationtosynapseregulationofiontransmembranetransportregulationofmembranepotentialregulationofsystemicarterialbloodpressurebyaorticarchbaroreceptorfeedbackregulationofvasoconstrictionresponsetoacidicpHsensoryperceptionofsoundsensoryperceptionofsourtastesodiumiontransmembranetransportsynapseassembly
Ceruloplasmin
2.0
nan
87
CERUCERUP00450P00450cellularironionhomeostasiscopperiontransportironionhomeostasisironiontransport
HLA class II histocompatibility antigen, DR beta 3 chain
2.0
83
80
DRB3DRB3P79483P79483adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIImyeloiddendriticcellantigenprocessingandpresentationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofCD4-positivealpha-betaTcellactivationpositiveregulationofTcellactivationpositiveregulationofTcellmediatedimmuneresponsetotumorcellsignaltransductionTcellreceptorsignalingpathway
Basigin (Ok blood group), isoform CRA_a
2.0
81
81
Q54A51Q54A51Q54A51Q54A51
Inducible T-cell costimulator
2.0
55
85
ICOSICOSQ9Y6W8Q9Y6W8cell-celladhesionimmuneresponseTcellcostimulationTcelltoleranceinduction
Neurogenic locus notch homolog protein 1
2.0
44
90
NOTC1NOTC1Q07008Q07008animalorganregenerationaorticvalvemorphogenesisapoptoticprocessapoptoticprocessinvolvedinembryonicdigitmorphogenesisarterialendothelialcelldifferentiationastrocytedifferentiationatrioventricularnodedevelopmentatrioventricularvalvemorphogenesisauditoryreceptorcellfatecommitmentaxonogenesisbraindevelopmentbranchingmorphogenesisofanepithelialtubecalcium-ionregulatedexocytosiscardiacatriummorphogenesiscardiacchamberformationcardiacepithelialtomesenchymaltransitioncardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationcardiacmusclecellproliferationcardiacmuscletissuemorphogenesiscardiacrightatriummorphogenesiscardiacrightventricleformationcardiacseptummorphogenesiscardiacvascularsmoothmusclecelldevelopmentcardiacventriclemorphogenesiscelldifferentiationcelldifferentiationinspinalcordcellfatecommitmentcellfatespecificationcellmigrationinvolvedinendocardialcushionformationcellpopulationproliferationcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetohypoxiacellularresponsetotumorcellcellularresponsetovascularendothelialgrowthfactorstimuluscentralnervoussystemdevelopmentciliumassemblycollectingductdevelopmentcompartmentpatternspecificationcoronaryarterymorphogenesiscoronarysinusvalvemorphogenesiscoronaryveinmorphogenesisdeterminationofleft/rightsymmetrydistaltubuledevelopmentembryonichindlimbmorphogenesisembryoniclimbmorphogenesisendocardialcelldifferentiationendocardialcushiondevelopmentendocardialcushionmorphogenesisendocardiumdevelopmentendocardiummorphogenesisendodermdevelopmentepidermalcellfatespecificationepidermisdevelopmentepithelialcellfatecommitmentepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationforebraindevelopmentforegutmorphogenesisgeneexpressionglialcelldifferentiationglomerularmesangialcelldevelopmentgrowthinvolvedinheartmorphogenesishairfolliclemorphogenesisheartdevelopmentheartloopinghearttrabeculamorphogenesishomeostasisofnumberofcellswithinatissuehumoralimmuneresponseinuteroembryonicdevelopmentinflammatoryresponsetoantigenicstimulusinhibitionofneuroepithelialcelldifferentiationinterleukin-17-mediatedsignalingpathwaykeratinocytedifferentiationleft/rightaxisspecificationliverdevelopmentlungdevelopmentmesenchymalcelldevelopmentmitralvalveformationnegativeregulationofanoikisnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofBMPsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclehypertrophynegativeregulationofcatalyticactivitynegativeregulationofcelladhesionmoleculeproductionnegativeregulationofcelldeathnegativeregulationofcelldifferentiationnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofcellproliferationinvolvedinheartvalvemorphogenesisnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcell-substrateadhesionnegativeregulationofcold-inducedthermogenesisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofendothelialcellchemotaxisnegativeregulationofepithelialcellproliferationnegativeregulationofextracellularmatrixconstituentsecretionnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofmyoblastdifferentiationnegativeregulationofmyotubedifferentiationnegativeregulationofneurogenesisnegativeregulationofneurondifferentiationnegativeregulationofoligodendrocytedifferentiationnegativeregulationofossificationnegativeregulationofosteoblastdifferentiationnegativeregulationofphotoreceptorcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIneuraltubedevelopmentneuroendocrinecelldifferentiationneurondifferentiationneuronfatecommitmentneuronalstemcellpopulationmaintenanceNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayNotchsignalingpathwayinvolvedinregulationofsecondaryheartfieldcardioblastproliferationoligodendrocytedifferentiationoutflowtractmorphogenesispericardiummorphogenesispositiveregulationofaortamorphogenesispositiveregulationofapoptoticprocesspositiveregulationofapoptoticprocessinvolvedinmorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacepithelialtomesenchymaltransitionpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcelldifferentiationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofglialcelldifferentiationpositiveregulationofkeratinocytedifferentiationpositiveregulationofneuroblastproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofRasproteinsignaltransductionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpositiveregulationofviralgenomereplicationpositiveregulationofviraltranscriptionprostateglandepitheliummorphogenesisproteincatabolicprocessproteinimportintonucleuspulmonaryvalvemorphogenesisregulationofcardioblastproliferationregulationofcellmigrationregulationofcellpopulationproliferationregulationofepithelialcellproliferationregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentregulationofextracellularmatrixassemblyregulationofgeneexpressionregulationofinnerearauditoryreceptorcelldifferentiationregulationofneurogenesisregulationofNotchsignalingpathwayregulationofsomitogenesisregulationofstemcellproliferationregulationoftranscriptionbyRNApolymeraseIIresponsetocorticosteroidresponsetolipopolysaccharideresponsetomuramyldipeptideretinalconecelldifferentiationsecretorycolumnalluminarepithelialcelldifferentiationinvolvedinprostateglandularacinusdevelopmentskeletalmusclecelldifferentiationskeletalsystemdevelopmentsomaticstemcelldivisionspermatogenesissproutingangiogenesisT-helper17typeimmuneresponsetissueregenerationtranscriptionbyRNApolymeraseIItubeformationvasculogenesisinvolvedincoronaryvascularmorphogenesisvenousbloodvesselmorphogenesisvenousendothelialcelldifferentiationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesis
Endothelin-converting enzyme 1
2.1
55
88
ECE1ECE1P42892P42892axonogenesisinvolvedininnervationbradykinincatabolicprocesscalcitonincatabolicprocesseardevelopmentembryonicdigitmorphogenesisembryonichearttubedevelopmentendothelinmaturationGprotein-coupledreceptorsignalingpathwayheartdevelopmenthormonecatabolicprocesspeptidehormoneprocessingpharyngealsystemdevelopmentpositiveregulationofreceptorrecyclingproteinprocessingregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesubstancePcatabolicprocesssympatheticneuronaxonguidance
Tetranectin
2.0
69
82
✔
TETNTETNP05452P05452bonemineralizationcellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimulusossificationpositiveregulationofplasminogenactivation
Dystrophin
2.0
61
81
DMDDMDP11532P11532actincytoskeletonorganizationcardiacmusclecellactionpotentialcardiacmusclecontractionmaintenanceofblood-brainbarriermotileciliumassemblymusclecellcellularhomeostasismusclecelldevelopmentmuscleorgandevelopmentnegativeregulationofpeptidyl-cysteineS-nitrosylationnegativeregulationofpeptidyl-serinephosphorylationneurondevelopmentpeptidebiosyntheticprocesspositiveregulationofneurondifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofsodiumiontransmembranetransporteractivityproteinlocalizationprotein-containingcomplexassemblyregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcellularresponsetogrowthfactorstimulusregulationofheartrateregulationofmusclesystemprocessregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofskeletalmusclecontractionregulationofskeletalmusclecontractionbyregulationofreleaseofsequesteredcalciumionregulationofvoltage-gatedcalciumchannelactivityresponsetomusclestretchskeletalmuscletissuedevelopment
Carboxypeptidase A2
2.0
51
87
CBPA2CBPA2P48052P48052proteincatabolicprocessinthevacuoleproteolysis
Trans-3-hydroxy-L-proline dehydratase
2.0
80
83
✔
T3HPDT3HPDQ96EM0Q96EM0
T cell receptor beta constant 2
2.0
73
79
K7N5M3TRBC2K7N5M3A0A5B9adaptiveimmuneresponsealpha-betaTcellactivationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationTcellreceptorsignalingpathway
Tumor necrosis factor receptor superfamily member 1A
2.0
53
89
TNR1ATNR1AP19438P19438aorticvalvedevelopmentcellularresponsetomechanicalstimuluscytokine-mediatedsignalingpathwaydefenseresponsetobacteriumextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsinflammatoryresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofcardiacmusclehypertrophynegativeregulationofextracellularmatrixconstituentsecretionnegativeregulationofinflammatoryresponsepositiveregulationofapoptoticprocessinvolvedinmorphogenesispositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinprostaglandinmetabolicprocessproteinlocalizationtoplasmamembranepulmonaryvalvedevelopmentregulationofestablishmentofendothelialbarrierregulationoftumornecrosisfactor-mediatedsignalingpathwaytranscriptionbyRNApolymeraseIItumornecrosisfactor-mediatedsignalingpathway
Ribonuclease 4
2.0
60
87
RNAS4RNAS4P34096P34096defenseresponsetoGram-positivebacteriummRNAcleavageRNAphosphodiesterbondhydrolysis
MHC class I heavy chain maturation peptide H-2K(D)
2.2
78
82
Q6RJ37Q6RJ37Q6RJ37Q6RJ37
IL17RB protein
2.0
62
86
A3KN55A3KN55A3KN55A3KN55
Alpha-(1,6)-fucosyltransferase
2.0
58
88
FUT8FUT8Q9BYC5Q9BYC5fibroblastmigrationGDP-L-fucosemetabolicprocessinuteroembryonicdevelopmentintegrin-mediatedsignalingpathwayL-fucosecatabolicprocessN-glycanfucosylationN-glycanprocessingoligosaccharidebiosyntheticprocessproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparaginereceptormetabolicprocessregulationofcellularresponsetooxidativestressregulationofgeneexpressionrespiratorygaseousexchangebyrespiratorysystemtransforminggrowthfactorbetareceptorsignalingpathwayviralproteinprocessing
Sodium channel protein type 3 subunit alpha
2.0
46
86
SCN3ASCN3AQ9NY46Q9NY46behavioralresponsetopainmembranedepolarizationduringactionpotentialneuronalactionpotentialregulationofiontransmembranetransportsodiumiontransmembranetransportsodiumiontransport
Reticulon-4 receptor-like 2
2.0
nan
88
R4RL2R4RL2Q80WD1Q80WD1cellsurfacereceptorsignalingpathwaycorpuscallosumdevelopmentnegativeregulationofneuronprojectiondevelopment
Thyroglobulin
2.0
42
90
A0A4W2CHS8A0A4W2CHS8A0A4W2CHS8A0A4W2CHS8hormonebiosyntheticprocess
receptor protein-tyrosine kinase
2.0
59
88
Q59HG2Q59HG2Q59HG2Q59HG2circulatorysystemdevelopmentregulationofcellmigrationregulationofmulticellularorganismaldevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Defensin alpha 5
2.0
50
87
DEF5DEF5Q01523Q01523antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdisruptionofcellsofanotherorganisminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellskillingofcellsofanotherorganismpositiveregulationofinterleukin-8productionpositiveregulationofmembranepermeabilityproteinhomotetramerization
Gap junction beta-2 protein
2.0
64
88
CXB2CXB2P29033P29033agingcell-cellsignalingcellularresponsetodexamethasonestimuluscellularresponsetoglucagonstimuluscellularresponsetooxidativestressdecidualizationepididymisdevelopmentgapjunctionassemblygapjunction-mediatedintercellulartransportinnereardevelopmentresponsetoantibioticresponsetoestradiolresponsetohumanchorionicgonadotropinresponsetoischemiaresponsetolipopolysaccharideresponsetoprogesteroneresponsetoretinoicacidsensoryperceptionofsoundtransmembranetransport
Protein polybromo-1
2.0
66
79
PB1PB1Q86U86Q86U86chromatinremodelingmitoticcellcyclenegativeregulationofcellpopulationproliferationpositiveregulationofcelldifferentiationpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofTcelldifferentiationregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
Semaphorin-7A
2.0
44
88
SEM7ASEM7AO75326O75326axonextensionaxonguidanceimmuneresponseinflammatoryresponseintegrin-mediatedsignalingpathwaynegativechemotaxisnegativeregulationofaxonextensioninvolvedinaxonguidanceneuralcrestcellmigrationolfactorylobedevelopmentosteoblastdifferentiationpositiveregulationofaxonextensionpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofproteinphosphorylationproteinphosphorylationregulationofinflammatoryresponsesemaphorin-plexinsignalingpathway
Cytochrome c oxidase assembly factor 6 homolog
2.0
47
87
COA6COA6Q5JTJ3Q5JTJ3mitochondrialATPsynthesiscoupledelectrontransportplasmamembraneATPsynthesiscoupledelectrontransportrespiratorychaincomplexIVassembly
Complement component C1q receptor
2.0
nan
94
C1QR1C1QR1Q9NPY3Q9NPY3cell-celladhesionmacrophageactivationphagocytosis
Killer cell lectin-like receptor subfamily B member 1A
2.0
72
85
G5E882G5E882G5E882G5E882
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
2.0
56
88
ENPP2ENPP2Q9R1E6Q9R1E6cellchemotaxisestrouscycleimmuneresponsenegativeregulationofcell-matrixadhesionphosphatidylcholinecatabolicprocessphospholipidcatabolicprocessphospholipidmetabolicprocesspositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoffocaladhesionassemblypositiveregulationoflamellipodiummorphogenesispositiveregulationofoligodendrocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofsubstrateadhesion-dependentcellspreadingregulationofcellmigrationsphingolipidcatabolicprocess
Elafin
2.1
53
87
ELAFELAFP19957P19957antibacterialhumoralresponsecopulationinnateimmuneresponsenegativeregulationofpeptidaseactivitypeptidecross-linking
Metalloproteinase inhibitor 2
2.0
nan
88
TIMP2TIMP2P16035P16035negativeregulationofendopeptidaseactivitynegativeregulationofmembraneproteinectodomainproteolysisnegativeregulationofmetallopeptidaseactivityresponsetocytokineresponsetohormoneresponsetoorganicsubstance
Steryl-sulfatase
2.0
52
86
STSSTSP08842P08842epidermisdevelopmentfemalepregnancysteroidcatabolicprocess
Ganglioside GM2 activator
2.0
51
87
SAP3SAP3P17900P17900gangliosidecatabolicprocessglycosphingolipidmetabolicprocesslearningormemorylipidstoragelipidtransportmaintenanceoflocationincellneuromuscularprocesscontrollingbalanceoligosaccharidecatabolicprocess
Lysosomal alpha-glucosidase
2.1
63
85
LYAGLYAGP10253P10253cardiacmusclecontractiondiaphragmcontractionglucosemetabolicprocessglycogencatabolicprocessglycophagyheartmorphogenesislocomotorybehaviorlysosomeorganizationmaltosemetabolicprocessmusclecellcellularhomeostasisneuromuscularprocesscontrollingbalanceneuromuscularprocesscontrollingpostureregulationoftheforceofheartcontractionsucrosemetabolicprocesstissuedevelopmentvacuolarsequestering
Carboxypeptidase B
2.0
44
84
CBPB1CBPB1P15086P15086proteolysis
Kelch-like protein 3
2.0
85
78
KLHL3KLHL3Q9UH77Q9UH77distaltubulemorphogenesisgeneexpressionionhomeostasispotassiumionhomeostasisproteinK48-linkedubiquitinationproteinphosphorylationproteinubiquitinationrenalsodiumionabsorptionselectiveautophagyubiquitin-dependentproteincatabolicprocess
Delta-like protein 1
2.0
nan
92
DLL1DLL1O00548O00548astrocytedevelopmentcelldifferentiationcellfatedeterminationcerebellarmolecularlayerformationcerebellarPurkinjecelllayerstructuralorganizationclathrin-dependentendocytosiscompartmentpatternspecificationdeterminationofleft/rightsymmetryendothelialtipcellfatespecificationenergyhomeostasisheartloopinghemopoiesisinhibitionofneuroepithelialcelldifferentiationinnerearauditoryreceptorcelldifferentiationlateralinhibitionleft/rightaxisspecificationloopofHenledevelopmentmarginalzoneBcelldifferentiationmyeloidcelldifferentiationnegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofepidermalcelldifferentiationnegativeregulationofepithelialcelldifferentiationnegativeregulationofglialcellapoptoticprocessnegativeregulationofhemocytedifferentiationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofinterleukin-10productionnegativeregulationofmyeloidcelldifferentiationnegativeregulationofmyoblastdifferentiationnegativeregulationofneurondifferentiationnegativeregulationofNotchsignalingpathwaynephrondevelopmentneuroepithelialcelldifferentiationneuronfatespecificationneuronalstemcellpopulationmaintenanceNotchsignalingpathwayNotchsignalingpathwayinvolvedinarterialendothelialcellfatecommitmentorgangrowthpositiveregulationofcellpopulationproliferationpositiveregulationofendocytosispositiveregulationofgeneexpressionpositiveregulationofNotchsignalingpathwaypositiveregulationofskeletalmuscletissuegrowthpositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIproximaltubuledevelopmentproximal/distalpatternformationregulationofbloodpressureregulationofcelladhesionregulationofcelldivisionregulationofgrowthregulationofneurogenesisregulationofskeletalmuscletissuegrowthregulationofsomitogenesisregulationofvascularendothelialgrowthfactorsignalingpathwayretinadevelopmentincamera-typeeyeretinamorphogenesisincamera-typeeyeskeletalmuscletissuegrowthskinepidermisdevelopmentsomitespecificationsomitogenesisspinalcorddevelopmenttypeBpancreaticcelldevelopment
Melanoma-derived growth regulatory protein
2.0
62
88
MIAMIAQ16674Q16674extracellularmatrixorganization
Phospholipase A2, major isoenzyme
2.0
55
88
PA21BPA21BP04054P04054actinfilamentorganizationactivationofphospholipaseA2activityantibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidearachidonicacidsecretioncellularresponsetoinsulinstimulusdefenseresponsetoGram-positivebacteriumfattyacidbiosyntheticprocessinnateimmuneresponseinmucosaintracellularsignaltransductionleukotrienebiosyntheticprocesslipidcatabolicprocessneutrophilchemotaxisneutrophilmediatedimmunityphosphatidylcholinemetabolicprocessphosphatidylglycerolmetabolicprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationofMAPkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpodocyteapoptoticprocesspositiveregulationofproteinsecretionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofglucoseimportsignaltransduction
Cholecystokinin receptor type A
2.0
30
85
CCKARCCKARP32238P32238axonogenesischolecystokininsignalingpathwayforebraindevelopmentGprotein-coupledreceptorsignalingpathwayneuronmigrationphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofhormonesecretion
Serine protease hepsin
2.0
63
84
HEPSHEPSP05981P05981basementmembranedisassemblycochleamorphogenesisdetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundnegativeregulationofapoptoticprocessnegativeregulationofepithelialcellproliferationnegativeregulationofepithelialtomesenchymaltransitionpilomotorreflexpositiveregulationbyhostofviraltranscriptionpositiveregulationofcellgrowthpositiveregulationofgeneexpressionpositiveregulationofhepatocyteproliferationpositiveregulationofplasminogenactivationpositiveregulationofthyroidhormonegenerationpotassiumiontransmembranetransportproteolysisregulationofcellshaperesponsetothyroidhormone
Metabotropic glutamate receptor 1
2.0
57
89
GRM1GRM1Q13255Q13255cellularresponsetoelectricalstimuluschemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayL-glutamateimportacrossplasmamembranelocomotorybehaviorpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofMAPKcascaderegulationofsensoryperceptionofpainregulationofsynaptictransmissionglutamatergicsensoryperceptionofpain
MHC class I antigen
2.1
80
82
U5YJM1U5YJM1U5YJM1U5YJM1
TGF-beta receptor type-2
2.0
58
84
TGFR2TGFR2P37173P37173activationofproteinkinaseactivityaginganimalorganregenerationaortamorphogenesisaorticvalvemorphogenesisapoptoticprocessarterymorphogenesisatrioventricularvalvemorphogenesisbloodvesseldevelopmentbraindevelopmentbranchinginvolvedinbloodvesselmorphogenesisbronchusmorphogenesiscardiacleftventriclemorphogenesiscellularresponsetogrowthfactorstimuluscommon-partnerSMADproteinphosphorylationdigestivetractdevelopmentembryoimplantationembryoniccranialskeletonmorphogenesisembryonichemopoiesisendocardialcushionfusiongastrulationgrowthplatecartilagechondrocytegrowthheartdevelopmentheartloopinginuteroembryonicdevelopmentinferiorendocardialcushionmorphogenesisLangerhanscelldifferentiationlensdevelopmentincamera-typeeyelensfibercellapoptoticprocesslunglobemorphogenesismammaryglandmorphogenesismembranousseptummorphogenesismiRNAtransportmyeloiddendriticcelldifferentiationnegativeregulationofcardiacmusclecellproliferationNotchsignalingpathwayoutflowtractmorphogenesisoutflowtractseptummorphogenesispathway-restrictedSMADproteinphosphorylationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofangiogenesispositiveregulationofBcelltoleranceinductionpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofmesenchymalcellproliferationpositiveregulationofNKTcelldifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofskeletalmuscletissueregenerationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcelltoleranceinductionpositiveregulationoftoleranceinductiontoselfantigenproteinphosphorylationreceptor-mediatedendocytosisregulationofcellpopulationproliferationregulationofgeneexpressionregulationofstemcellproliferationresponsetocholesterolresponsetoestrogenresponsetoglucoseresponsetohypoxiaresponsetomechanicalstimulusresponsetonutrientresponsetosteroidhormoneresponsetoxenobioticstimulusroofofmouthdevelopmentsecondarypalatedevelopmentsmoothenedsignalingpathwaytracheaformationtransforminggrowthfactorbetareceptorsignalingpathwaytricuspidvalvemorphogenesisvasculogenesisventricularseptummorphogenesiswoundhealing
Interleukin-1 receptor accessory protein
2.0
nan
89
IL1APIL1APQ9NPH3Q9NPH3immuneresponseinflammatoryresponseinnateimmuneresponsepositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-4productionpositiveregulationofinterleukin-5productionpositiveregulationofinterleukin-6productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofsynapseassemblyprotein-containingcomplexassemblyregulationofpostsynapticdensityassemblyregulationofpresynapseassemblysynapticmembraneadhesiontrans-synapticsignalingbytrans-synapticcomplex
Mammalian ependymin-related protein 1
2.0
nan
89
EPDR1EPDR1Q9UM22Q9UM22cell-matrixadhesionmyofibroblastcontraction
Hepatocyte growth factor
2.0
nan
90
HGFHGFP14210P14210animalorganregenerationcellchemotaxiscellmorphogenesiscellularresponsetohepatocytegrowthfactorstimulusepithelialcellproliferationepithelialtomesenchymaltransitionhepatocytegrowthfactorreceptorsignalingpathwayliverdevelopmentmitoticcellcyclemyoblastproliferationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofinterleukin-10productionpositiveregulationofMAPKcascadepositiveregulationofmyelinationpositiveregulationofneuronprojectionregenerationpositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofp38MAPKcascaderegulationoftau-proteinkinaseactivityskeletalmusclecellproliferation
Nectin-1
2.0
73
85
NECT1NECT1Q15223Q15223axonguidancecelladhesioncell-celladhesiondesmosomeorganizationenamelmineralizationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomophiliccelladhesionviaplasmamembraneadhesionmoleculesimmuneresponseironiontransportlensmorphogenesisincamera-typeeyeproteinlocalizationtocelljunctionregulationofsynapseassemblyretinadevelopmentincamera-typeeyeviralentryintohostcell
HLA class I histocompatibility antigen A alpha chain
2.0
86
81
Q2LC95Q2LC95Q2LC95Q2LC95antigenprocessingandpresentationimmuneresponse
Lectin-related NK cell receptor LY49L4
2.1
36
89
Q9JIP9Q9JIP9Q9JIP9Q9JIP9
Angiopoietin-1 receptor
2.0
61
89
TIE2TIE2Q02763Q02763angiogenesiscell-cellsignalingdefinitivehemopoiesisendothelialcellproliferationglomerulusvasculaturedevelopmentheartdevelopmenthearttrabeculaformationnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofinflammatoryresponsepeptidyl-tyrosinephosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofangiogenesispositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofintracellularsignaltransductionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationproteinautophosphorylationregulationofendothelialcellapoptoticprocessregulationofestablishmentormaintenanceofcellpolarityregulationofvascularpermeabilitysignaltransductionsproutingangiogenesissubstrateadhesion-dependentcellspreadingTiesignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathway
Pancreatic triacylglycerol lipase
2.0
58
86
LIPPLIPPP16233P16233intestinalcholesterolabsorptionlipidcatabolicprocesslipidmetabolicprocesspositiveregulationoftriglyceridelipaseactivity
Carboxypeptidase A1
2.0
46
84
A6H6Y4A6H6Y4A6H6Y4A6H6Y4proteolysis
EPH receptor B6
2.0
69
88
F8WCM8F8WCM8F8WCM8F8WCM8activatedTcellproliferationpositiveregulationofproteinbindingpositiveregulationofTcellcostimulationtypeIVhypersensitivity
MBL associated serine protease 2
2.0
53
89
A2VCV7A2VCV7A2VCV7A2VCV7complementactivationlectinpathwayproteolysis
Fibrinogen-like protein 1
2.0
67
83
FGL1FGL1Q08830Q08830adaptiveimmuneresponsehepatocyteproliferationnegativeregulationofTcellactivationregulationofimmuneresponse
Apolipoprotein(a)
2.0
nan
94
APOAAPOAP08519P08519bloodcirculationlipidmetabolicprocesslipidtransportproteolysis
Fibrinogen alpha chain
2.0
24
91
FIBAFIBAP02671P02671adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumion
Mast/stem cell growth factor receptor Kit
2.0
59
87
KITKITP10721P10721actincytoskeletonreorganizationBcelldifferentiationcellchemotaxiscellularresponsetothyroidhormonestimuluscytokine-mediatedsignalingpathwaydetectionofmechanicalstimulusinvolvedinsensoryperceptionofsounddigestivetractdevelopmentectopicgermcellprogrammedcelldeathembryonichemopoiesisepithelialcellproliferationerythrocytedifferentiationerythropoietin-mediatedsignalingpathwayFcreceptorsignalingpathwaygermcellmigrationglycosphingolipidmetabolicprocesshematopoieticprogenitorcelldifferentiationhematopoieticstemcellmigrationhemopoiesisimmatureBcelldifferentiationinflammatoryresponseintracellularsignaltransductionKitsignalingpathwaylamellipodiumassemblylymphoidprogenitorcelldifferentiationmalegonaddevelopmentmastcellchemotaxismastcelldegranulationmastcelldifferentiationmastcellproliferationmegakaryocytedevelopmentmelanocyteadhesionmelanocytedifferentiationmelanocytemigrationmyeloidprogenitorcelldifferentiationnegativeregulationofdevelopmentalprocessnegativeregulationofprogrammedcelldeathnegativeregulationofreproductiveprocessovarianfollicledevelopmentpigmentationpositiveregulationofcellmigrationpositiveregulationofcolonsmoothmusclecontractionpositiveregulationofdendriticcellcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofkinaseactivitypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellcytokineproductionpositiveregulationofmastcellproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivitypositiveregulationofpseudopodiumassemblypositiveregulationofpyloricantrumsmoothmusclecontractionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmallintestinesmoothmusclecontractionpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecelldifferentiationproteinautophosphorylationregulationofbileacidmetabolicprocessregulationofcellpopulationproliferationregulationofcellshaperegulationofMAPKcascaderesponsetocadmiumionsignaltransductionsomaticstemcelldivisionsomaticstemcellpopulationmaintenancespermatiddevelopmentspermatogenesisstemcelldifferentiationstemcellpopulationmaintenanceTcelldifferentiationtonguedevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayvisuallearning
Follistatin
2.0
54
88
FSTFSTP19883P19883ameloblastdifferentiationBMPsignalingpathwaycelldifferentiationfemalegonaddevelopmentgametegenerationhairfolliclemorphogenesishematopoieticprogenitorcelldifferentiationkeratinocyteproliferationnegativeregulationofactivinreceptorsignalingpathwaynegativeregulationofepithelialcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIodontogenesisofdentin-containingtoothpatternspecificationprocesspositiveregulationofhairfollicledevelopmentregulationofBMPsignalingpathwayresponsetoorganiccycliccompoundskeletalsystemdevelopment
Very low-density lipoprotein receptor
2.0
nan
90
VLDLRVLDLRP98155P98155cholesterolmetabolicprocessdendritemorphogenesisglycoproteintransportlipidtransportmemorynervoussystemdevelopmentpositiveregulationofdendritedevelopmentpositiveregulationofproteinkinaseactivityreceptor-mediatedendocytosisreelin-mediatedsignalingpathwaysignaltransductionventralspinalcorddevelopmentvery-low-densitylipoproteinparticleclearance
Interferon alpha/beta receptor 2
2.0
67
85
INAR2INAR2P48551P48551cellsurfacereceptorsignalingpathwaycellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirusreceptorsignalingpathwayviaJAK-STATresponsetointerferon-alpharesponsetointerferon-betaresponsetovirustypeIinterferon-mediatedsignalingpathway
Netrin-G2
2.0
46
88
NTNG2NTNG2Q96CW9Q96CW9animalorganmorphogenesisaxonogenesisbasementmembraneassemblycellmigrationmodulationofchemicalsynaptictransmissionpostsynapticspecializationassemblyregulationofneuronmigrationregulationofneuronprojectionarborizationregulationofneuronprojectiondevelopmentregulationofpresynapseassemblysubstrateadhesion-dependentcellspreadingsynapticmembraneadhesiontissuedevelopment
C-X-C motif chemokine
2.0
71
83
Q0EAC2Q0EAC2Q0EAC2Q0EAC2immuneresponseinflammatoryresponse
Annexin A8
2.0
67
82
ANXA8ANXA8P13928P13928bloodcoagulationendosomaltransportendosomeorganizationnegativeregulationofphospholipaseA2activitynegativeregulationofserine-typeendopeptidaseactivity
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
2.0
72
81
HS3SAHS3SAQ9Y663Q9Y663branchinginvolvedinuretericbudmorphogenesisglycosaminoglycanbiosyntheticprocessheparansulfateproteoglycanbiosyntheticprocessenzymaticmodification
Anti-human Langerin 2G3 lambda chain
2.1
50
84
IGHMG0YP42P01872-2G0YP42
Prosaposin
2.0
46
87
SAPSAPP07602P07602adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayepithelialcelldifferentiationinvolvedinprostateglanddevelopmentgangliosideGM1transporttomembranelysosomaltransportpositiveregulationofbeta-galactosidaseactivityprostateglandgrowthregulationofautophagyregulationoflipidmetabolicprocesssphingolipidmetabolicprocess
Toll-like receptor 7
2.0
38
88
B3Y653B3Y653B3Y653B3Y653cellularresponsetomechanicalstimuluscellularresponsetovirusdefenseresponsetovirusI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationinflammatoryresponseinnateimmuneresponseJNKcascadepositiveregulationofchemokineproductionpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionregulationofproteinphosphorylationresponsetocGMPtoll-likereceptor7signalingpathwaytoll-likereceptorsignalingpathway
Intelectin-1
2.0
nan
90
ITLN1ITLN1Q8WWA0Q8WWA0positiveregulationofglucoseimportpositiveregulationofproteinphosphorylationproteinhomotrimerizationresponsetonematode
Contactin-3
2.0
77
82
CNTN3CNTN3Q07409Q07409celladhesionnervoussystemdevelopment
CD320 antigen
2.0
55
87
✔
CD320CD320Q9NPF0Q9NPF0BcellcostimulationcobalamintransportpositiveregulationofBcellproliferationregulationofvitaminmetabolicprocess
Dickkopf-related protein 4
2.0
45
89
DKK4DKK4Q9UBT3Q9UBT3negativeregulationofcanonicalWntsignalingpathwaynegativeregulationofhairfollicleplacodeformationnegativeregulationofWntsignalingpathwayWntsignalingpathway
Myeloblastin
2.0
64
85
PRTN3PRTN3P24158P24158antimicrobialhumoralresponsecell-celljunctionmaintenancecollagencatabolicprocessmatureconventionaldendriticcelldifferentiationmembraneproteinectodomainproteolysisnegativeregulationofphagocytosisneutrophilextravasationphagocytosispositiveregulationofcellpopulationproliferationpositiveregulationofGTPaseactivityproteolysis
Killer cell lectin-like receptor subfamily B member 1
2.1
50
85
KLRB1KLRB1Q12918Q12918cellsurfacereceptorsignalingpathwayregulationofnaturalkillercellmediatedcytotoxicity
HLA class II DR-beta (HLA-DR B)
2.0
81
79
Q29890Q29890Q29890Q29890adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Mucolipin-1
2.0
46
86
MCLN1MCLN1Q9GZU1Q9GZU1adaptiveimmuneresponseautophagosomematurationcalciumiontransmembranetransportcationtransportcellularresponsetocalciumioncellularresponsetopHphagosomematurationproteinhomotetramerizationtransferrintransport
Brain-derived neurotrophic factor
2.0
74
86
BDNFBDNFP23560P23560axonguidancebrain-derivedneurotrophicfactorreceptorsignalingpathwaycollateralsproutingmemorymodulationofchemicalsynaptictransmissionnegativeregulationofapoptoticsignalingpathwaynegativeregulationofmyotubedifferentiationnegativeregulationofneuronapoptoticprocessnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofbrain-derivedneurotrophicfactorreceptorsignalingpathwaypositiveregulationofcollateralsproutingpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofreceptorbindingpositiveregulationofsynapseassemblyregulationofneurondifferentiationregulationofproteinlocalizationtocellsurfacesynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathway
Complement receptor type 2
2.0
57
86
CR2CR2P20023P20023BcelldifferentiationBcellproliferationcomplementactivationalternativepathwaycomplementactivationclassicalpathwayimmuneresponsenegativeregulationofcomplementactivationclassicalpathway
Insulin-like growth factor 2 receptor variant
2.0
76
83
Q59EZ3Q59EZ3Q59EZ3Q59EZ3lysosomaltransport
Adhesion G protein-coupled receptor G3
2.0
62
86
AGRG3AGRG3Q86Y34Q86Y34adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayBcelldifferentiationcellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaynegativeregulationofCREBtranscriptionfactoractivitynegativeregulationofNIK/NF-kappaBsignalingregulationofcellmigration
Fibroblast growth factor receptor 1
2.0
70
84
FGFR1FGFR1P11362P11362cellmigrationchordateembryonicdevelopmentepithelialtomesenchymaltransitionfibroblastgrowthfactorreceptorsignalingpathwayMAPKcascadeneuronmigrationpeptidyl-tyrosinephosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellchemotaxistofibroblastgrowthfactorpositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofneurondifferentiationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofvascularendothelialcellproliferationproteinautophosphorylationproteinphosphorylationregulationofcelldifferentiationregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandskeletalsystemdevelopmentskeletalsystemmorphogenesistransmembranereceptorproteintyrosinekinasesignalingpathway
C-C motif chemokine 28
2.0
49
85
CCL28CCL28Q9NRJ3Q9NRJ3antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxischemotaxiscytolysisinanotherorganismimmuneresponsekillingofcellsofanotherorganismnegativeregulationofleukocytetetheringorrollingpositiveregulationofcell-matrixadhesionpositiveregulationofcytosoliccalciumionconcentrationresponsetonutrient
Oncostatin-M
2.0
45
87
ONCMONCMP13725P13725immuneresponsenegativeregulationofcellpopulationproliferationnegativeregulationofhormonesecretiononcostatin-M-mediatedsignalingpathwaypositiveregulationofacuteinflammatoryresponsepositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofMAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofhematopoieticstemcelldifferentiation
ELR1
2.0
65
90
Q4G265Q4G265Q4G265Q4G265
Glycoprotein hormones alpha chain
2.0
64
85
GLHAGLHAP01215P01215follicle-stimulatinghormonesecretionfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayluteinizinghormonesecretionnegativeregulationoforgangrowthorgangrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsignalingreceptoractivitythyroidglanddevelopmentthyroidhormonegeneration
Macrophage mannose receptor 1
2.0
68
85
MRC1MRC1P22897P22897cellularresponsetointerleukin-4cellularresponsetolipopolysaccharidecellularresponsetotypeIIinterferonreceptor-mediatedendocytosis
Cathepsin G
2.0
68
85
CATGCATGP08311P08311angiotensinmaturationantibacterialhumoralresponsebiofilmmatrixdisassemblycellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwaydefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumextracellularmatrixdisassemblyimmuneresponsemonocytechemotaxisnegativeregulationofTcellactivationneutrophilactivationneutrophil-mediatedkillingofgram-positivebacteriumplateletactivationpositiveregulationofimmuneresponsepositiveregulationofplateletaggregationproteinmetabolicprocessproteinphosphorylationproteinprocessingproteolysispurinergicnucleotidereceptorsignalingpathway
Protocadherin gamma B2-alpha C
2.0
51
86
Q8K486Q8K486Q8K486Q8K486homophiliccelladhesionviaplasmamembraneadhesionmolecules
MHC class I antigen
2.1
72
83
Q95IT0Q95IT0Q95IT0Q95IT0antigenprocessingandpresentationimmuneresponse
Lymphocyte activation gene 3 protein
2.0
75
83
✔
LAG3LAG3P18627P18627adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedcytotoxicitynegativeregulationofinterleukin-2productionnegativeregulationofregulatoryTcelldifferentiationplasmacytoiddendriticcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofimmuneresponseTcellactivation
Immunoglobulin heavy constant gamma 4
2.0
78
81
IGHG4IGHG4P01861P01861adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Macrophage-stimulating protein receptor
2.0
69
86
RONRONQ04912Q04912cellmigrationdefenseresponseinnateimmuneresponsenervoussystemdevelopmentphagocytosispositiveregulationofcellpopulationproliferationpositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofproteinkinaseBsignalingresponsetovirussignaltransductionsinglefertilizationtransmembranereceptorproteintyrosinekinasesignalingpathway
MHC class I antigen
2.1
84
82
D2KZ37D2KZ37D2KZ37D2KZ37
Prolow-density lipoprotein receptor-related protein 1
2.0
52
89
LRP1LRP1Q07954Q07954amyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessamyloid-betaclearancebytranscytosisaortamorphogenesisapoptoticcellclearanceastrocyteactivationinvolvedinimmuneresponsecellularresponsetoamyloid-betaenzyme-linkedreceptorproteinsignalingpathwaylipidmetabolicprocesslipoproteintransportlysosomaltransportnegativeregulationofgeneexpressionnegativeregulationofmetallopeptidaseactivitynegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofplatelet-derivedgrowthfactorreceptor-betasignalingpathwaynegativeregulationofSMADproteinsignaltransductionnegativeregulationofsmoothmusclecellmigrationnegativeregulationofWntsignalingpathwayphagocytosispositiveregulationofamyloid-betaclearancepositiveregulationofcelldeathpositiveregulationofcholesteroleffluxpositiveregulationofcholesteroltransportpositiveregulationofendocytosispositiveregulationoflipidtransportpositiveregulationoflysosomalproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationoftranscytosisreceptorinternalizationreceptor-mediatedendocytosisregulationofactincytoskeletonorganizationregulationofcholesteroltransportregulationofextracellularmatrixdisassemblyregulationofphospholipaseA2activityretinoidmetabolicprocesstranscytosistransportacrossblood-brainbarrier
GDNF family receptor alpha-1
2.0
57
86
GFRA1GFRA1P56159P56159agingcellmigrationcellsurfacereceptorsignalingpathwaykidneydevelopmentmalegonaddevelopmentnervoussystemdevelopmentneuronprojectiondevelopmentpositiveregulationofpeptidyl-tyrosinephosphorylation
DDB1- and CUL4-associated factor 1
2.0
58
88
DCAF1DCAF1Q9Y4B6Q9Y4B6BcelldifferentiationcellcompetitioninamulticellularorganismchromatinorganizationnegativeregulationoftranscriptionbyRNApolymeraseIIphosphorylationpost-translationalproteinmodificationproteinubiquitinationV(D)Jrecombination
Complement receptor type 1
2.0
58
89
CR1CR1P17927P17927ATPexportcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplementreceptormediatedsignalingpathwayimmunecomplexclearancebyerythrocytesnegativeregulationofactivationofmembraneattackcomplexnegativeregulationofcomplementactivationnegativeregulationofcomplementactivationalternativepathwaynegativeregulationofcomplementactivationclassicalpathwaynegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofimmunoglobulinproductionnegativeregulationofinterleukin-2productionnegativeregulationofplasmacelldifferentiationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofTcellproliferationnegativeregulationoftypeIIinterferonproductionplasmamembraneorganizationpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofcellpopulationproliferationpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofserine-typeendopeptidaseactivity
Amphiregulin
2.0
52
88
✔
AREGAREGP15514P15514cell-cellsignalingdichotomoussubdivisionofterminalunitsinvolvedinmammaryglandductmorphogenesisepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationinvolvedinmammaryglandductelongationERBB2-EGFRsignalingpathwayGprotein-coupledreceptorsignalingpathwayglialcellproliferationmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinthelarchenegativeregulationofosteoblastdifferentiationneuronprojectiondevelopmentpositiveregulationofcellpopulationproliferationpositiveregulationofepidermalgrowthfactor-activatedreceptoractivitypositiveregulationofkeratinocyteproliferationresponsetocAMPresponsetoestradiolresponsetoglucocorticoidresponsetohydrogenperoxideresponsetopeptidehormone
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
2.0
72
86
A0A0C4DFQ5A0A0C4DFQ5A0A0C4DFQ5A0A0C4DFQ5amelogenesisextracellularmatrixdisassemblyproteincatabolicprocessproteolysis
Sodium channel protein type 2 subunit alpha
2.0
68
85
SCN2ASCN2AQ99250Q99250cellularresponsetohypoxiaintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressmembranedepolarizationduringactionpotentialmemorymyelinationnervoussystemdevelopmentneuronapoptoticprocessneuronalactionpotentialregulationofiontransmembranetransportsodiumiontransmembranetransportsodiumiontransport
Sodium channel protein type 1 subunit alpha
2.0
57
87
SCN1ASCN1AP35498P35498adultwalkingbehaviorcardiacmusclecellactionpotentialinvolvedincontractiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainestablishmentoflocalizationincellmembranedepolarizationduringactionpotentialneuromuscularprocesscontrollingpostureneuronalactionpotentialneuronalactionpotentialpropagationregulationofiontransmembranetransportsodiumiontransmembranetransportsodiumiontransport
Scavenger receptor cysteine-rich type 1 protein M160
2.0
65
86
C163BC163BQ9NR16Q9NR16
Neuroplastin
2.0
74
82
NPTNNPTNP97546P97546axonguidancecellularcalciumionhomeostasisdendriteself-avoidanceexcitatorysynapseassemblyhomophiliccelladhesionviaplasmamembraneadhesionmoleculeslong-termsynapticpotentiationmodulationofchemicalsynaptictransmissionnegativeregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationoflong-termsynapticpotentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofproteinlocalizationpositiveregulationofproteinphosphorylationregulationofcelladhesionregulationofreceptorlocalizationtosynapsesynapseorganizationtrans-synapticsignalingbytrans-synapticcomplexmodulatingsynaptictransmissionvisuallearning
Nectin-4
2.0
78
82
NECT4NECT4Q96NY8Q96NY8heterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomophiliccelladhesionviaplasmamembraneadhesionmolecules
C-C motif chemokine 15
2.0
42
87
CCL15CCL15Q16663Q16663cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransduction
Prorelaxin H2
2.0
nan
90
REL2REL2P04090P04090femalepregnancypositiveregulationofangiogenesispositiveregulationofgeneexpressionregulationofcatalyticactivity
Insulin receptor
2.0
36
89
INSRINSRP06213-2P06213-2
Integrin alpha-X
2.0
41
87
ITAXITAXP20702P20702animalorganmorphogenesiscelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesiondefenseresponsetovirusheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialtubemorphogenesispositiveregulationofgeneexpressionpositiveregulationofmyelination
Ribonuclease 7
2.0
60
87
RNAS7RNAS7Q9H1E1Q9H1E1antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecytolysisinanotherorganismdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
High affinity nerve growth factor receptor
2.0
nan
89
NTRK1NTRK1P04629P04629agingaxonguidanceaxonogenesisinvolvedininnervationBcelldifferentiationbehavioralresponsetoformalininducedpaincellularresponsetonervegrowthfactorstimuluscellularresponsetonicotinecircadianrhythmdetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainlearningormemorymechanoreceptordifferentiationnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofneuronapoptoticprocessnervegrowthfactorsignalingpathwayneuronapoptoticprocessneurondevelopmentneuronprojectiondevelopmentneurotrophinTRKreceptorsignalingpathwayolfactorynervedevelopmentpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofangiogenesispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofkinaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofprogrammedcelldeathpositiveregulationofproteinphosphorylationpositiveregulationofRasproteinsignaltransductionpositiveregulationofsynapseassemblypositiveregulationofsynaptictransmissionglutamatergicprogrammedcelldeathinvolvedincelldevelopmentproteinautophosphorylationproteinphosphorylationregulationofproteinkinaseBsignalingresponsetoaxoninjuryresponsetoelectricalstimulusresponsetohydrostaticpressureresponsetonutrientlevelsresponsetoradiationresponsetoxenobioticstimulusSertolicelldevelopmentsympatheticnervoussystemdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Epidermal growth factor receptor
2.0
nan
92
EGFREGFRP00533P00533activationofphospholipaseCactivitycellmorphogenesiscellsurfacereceptorsignalingpathwaycell-celladhesioncellularresponsetoaminoacidstimuluscellularresponsetocadmiumioncellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoestradiolstimuluscellularresponsetoreactiveoxygenspeciescerebralcortexcellmigrationdigestivetractmorphogenesisembryonicplacentadevelopmentepidermalgrowthfactorreceptorsignalingpathwayepithelialcellproliferationERBB2-EGFRsignalingpathwayeyeliddevelopmentincamera-typeeyehairfollicledevelopmentlearningormemorymorphogenesisofanepithelialfoldnegativeregulationofapoptoticprocessnegativeregulationofcardiocytedifferentiationnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteincatabolicprocessneurogenesisossificationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNArepairpositiveregulationofDNAreplicationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmiRNAtranscriptionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCactivitypositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinautophosphorylationproteininsertionintomembraneregulationofERK1andERK2cascaderegulationofJNKcascaderegulationofnitric-oxidesynthaseactivityregulationofpeptidyl-tyrosinephosphorylationregulationofphosphatidylinositol3-kinasesignalingresponsetoUV-Asalivaryglandmorphogenesissignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Beta-2-microglobulin
2.0
82
80
B2MGB2MGP61770P61770antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigenviaMHCclassIimmuneresponsepeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
Nicastrin
2.0
62
84
NICANICAQ92542Q92542adultbehavioramyloidprecursorproteinbiosyntheticprocessamyloidprecursorproteincatabolicprocessamyloidprecursorproteinmetabolicprocessamyloid-betaformationcellularresponsetocalciumioncentralnervoussystemmyelinationcerebellumdevelopmentdopaminereceptorsignalingpathwayepithelialcellproliferationglutamatereceptorsignalingpathwaylearningormemorymembraneproteinectodomainproteolysismembraneproteinintracellulardomainproteolysismyeloidcellhomeostasisneuronapoptoticprocessNotchreceptorprocessingNotchsignalingpathwaypositiveregulationofamyloidprecursorproteinbiosyntheticprocesspositiveregulationofcatalyticactivitypositiveregulationofendopeptidaseactivityproteinprocessingproteolysisregulationoflong-termsynapticpotentiationshort-termsynapticpotentiationTcellproliferation
P-selectin
2.0
57
88
LYAM3LYAM3P16109P16109calcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescalcium-mediatedsignalingusingintracellularcalciumsourcecelladhesiondefenseresponsetoGram-negativebacteriumheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinflammatoryresponseleukocytecell-celladhesionleukocytetetheringorrollingpositiveregulationofleukocytemigrationpositiveregulationofleukocytetetheringorrollingpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofplateletactivationregulationofintegrinactivationresponsetocytokineresponsetolipopolysaccharide
MHC class I antigen
2.1
83
82
A0MSS3A0MSS3A0MSS3A0MSS3
Tumor necrosis factor ligand superfamily member 6
2.0
46
89
TNFL6TNFL6P48023P48023activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessapoptoticsignalingpathwaycell-cellsignalingcellularchlorideionhomeostasiscellularresponsetotypeIIinterferonendosomallumenacidificationextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsinflammatorycellapoptoticprocessnecroptoticprocessnecroptoticsignalingpathwaynegativeregulationofangiogenesisnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofneuronapoptoticprocesspositiveregulationofphosphatidylserineexposureonapoptoticcellsurfacereleaseofsequesteredcalciumionintocytosolbyendoplasmicreticulumresponsetogrowthfactorresponsetolipopolysaccharideretinalcellprogrammedcelldeathsignaltransductionTcellapoptoticprocess
Ubiquitin carboxyl-terminal hydrolase 5
3.7
48
86
UBP5UBP5P45974-2P45974-2
NPC intracellular cholesterol transporter 1
2.0
nan
89
NPC1NPC1O15118O15118adultwalkingbehaviorautophagybileacidmetabolicprocesscellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetosteroidhormonestimuluscholesteroleffluxcholesterolhomeostasischolesterolmetabolicprocesscholesteroltransportendocytosisestablishmentofproteinlocalizationtomembranegeneexpressionintestinalcholesterolabsorptionintracellularcholesteroltransportlysosomaltransportmacroautophagymembraneraftorganizationnegativeregulationofcelldeathnegativeregulationofmacroautophagynegativeregulationofTORC1signalingproteinglycosylationresponsetocadmiumionresponsetoxenobioticstimulussteroltransportviralentryintohostcell
Trophoblast glycoprotein
2.1
nan
88
TPBGTPBGQ13641Q13641celladhesioncellchemotaxisdendritearborizationmesenchymalcellmigrationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationolfactorylearningpositiveregulationofchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofproteinkinaseBsignalingpositiveregulationofsynapseassemblyproteinlocalizationtoplasmamembranesynaptictransmissionGABAergic
Fibrillin-1
2.1
49
91
FBN1FBN1P35555P35555activationofproteinkinaseAactivityanatomicalstructuremorphogenesiscamera-typeeyedevelopmentcelladhesionmediatedbyintegrincellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimulusembryoniceyemorphogenesisglucosehomeostasisglucosemetabolicprocessheartdevelopmentmetanephrosdevelopmentnegativeregulationofosteoclastdevelopmentnegativeregulationofosteoclastdifferentiationpositiveregulationofappetitepost-embryoniceyemorphogenesisproteinkinaseAsignalingsequesteringofBMPinextracellularmatrixsequesteringofTGFbetainextracellularmatrixskeletalsystemdevelopment
Vitamin K-dependent protein Z
2.0
55
89
PROZPROZP22891P22891bloodcoagulationproteolysis
Tumor-associated calcium signal transducer 2
2.0
56
89
TACD2TACD2P09758P09758negativeregulationofbranchinginvolvedinuretericbudmorphogenesisnegativeregulationofcellmotilitynegativeregulationofepithelialcellmigrationnegativeregulationofruffleassemblynegativeregulationofstressfiberassemblynegativeregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofstemcelldifferentiationregulationofepithelialcellproliferationresponsetostimulusuretericbudmorphogenesisvisualperception
Kallikrein-2
2.0
69
84
KLK2KLK2P20151P20151regulationofsystemicarterialbloodpressurezymogenactivation
Prostasin
2.0
69
84
PRSS8PRSS8Q16651Q16651positiveregulationofsodiumiontransportproteolysis
Glucagon receptor
2.0
57
87
GLRGLRP47871P47871adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwaycellularresponsetoglucagonstimuluscellularresponsetostarvationexocytosisgenerationofprecursormetabolitesandenergyglucosehomeostasishormone-mediatedsignalingpathwaypositiveregulationofgeneexpressionregulationofbloodpressureregulationofglycogenmetabolicprocessresponsetonutrientresponsetostarvation
Bone morphogenetic protein 7
2.0
63
88
BMP7BMP7P18075P18075allantoisdevelopmentameloblastdifferentiationaxonguidanceBMPsignalingpathwaybranchinginvolvedinsalivaryglandmorphogenesisbranchingmorphogenesisofanepithelialtubecardiacmuscletissuedevelopmentcardiacseptummorphogenesiscartilagedevelopmentcellularresponsetoBMPstimuluscellularresponsetohypoxiachorio-allantoicfusiondendritedevelopmentembryoniccamera-typeeyemorphogenesisembryoniclimbmorphogenesisembryonicpatternspecificationembryonicskeletaljointmorphogenesisendocardialcushionformationepithelialtomesenchymaltransitionhearttrabeculamorphogenesishindbraindevelopmentmesenchymalcellapoptoticprocessinvolvedinnephronmorphogenesismesenchymalcelldifferentiationmesenchymedevelopmentmesodermformationmesonephrosdevelopmentmetanephricmesenchymalcellproliferationinvolvedinmetanephrosdevelopmentmetanephricmesenchymemorphogenesismetanephrosdevelopmentmonocyteaggregationnegativeregulationofcellcyclenegativeregulationofcelldeathnegativeregulationofDNA-templatedtranscriptionnegativeregulationofglomerularmesangialcellproliferationnegativeregulationofMAPkinaseactivitynegativeregulationofmesenchymalcellapoptoticprocessinvolvedinnephronmorphogenesisnegativeregulationofmitoticnucleardivisionnegativeregulationofneurogenesisnegativeregulationofneurondifferentiationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofNotchsignalingpathwaynegativeregulationofphosphorylationnegativeregulationofprostaticbudformationnegativeregulationofstriatedmusclecellapoptoticprocessnephrogenicmesenchymemorphogenesisneuralfoldelevationformationneuronprojectionmorphogenesisodontogenesisofdentin-containingtoothossificationpericardiummorphogenesispharyngealsystemdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofbrownfatcelldifferentiationpositiveregulationofcardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesispositiveregulationofdendritedevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcelldifferentiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofheterotypiccell-celladhesionpositiveregulationofhyaluranoncableassemblypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtonucleusregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofpathway-restrictedSMADproteinphosphorylationregulationofremovalofsuperoxideradicalsresponsetoestradiolresponsetopeptidehormoneresponsetovitaminDskeletalsystemdevelopmentSMADproteinsignaltransductionsteroidhormonemediatedsignalingpathwayuretericbuddevelopment
Complement C2
2.0
54
88
CO2CO2P06681P06681complementactivationcomplementactivationclassicalpathwayinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonizationproteolysisresponsetobacteriumresponsetolipopolysaccharideresponsetothyroidhormone
Insulin-like growth factor-binding protein 3
2.0
52
86
IBP3IBP3P17936P17936apoptoticprocessMAPKcascadenegativeregulationofcellpopulationproliferationnegativeregulationofproteinphosphorylationnegativeregulationofsignaltransductionnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationosteoblastdifferentiationpositiveregulationofapoptoticprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmyoblastdifferentiationproteinphosphorylationregulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwaytypeBpancreaticcellproliferation
Insulin, isoform 2
2.0
60
86
INSINSR2P01308F8WCM5activationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcell-cellsignalingcognitionfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofgluconeogenesisnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationoflipidbiosyntheticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidehormonesecretionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstregulationofcellularaminoacidmetabolicprocessregulationofDNA-templatedtranscriptionregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationofsynapticplasticityregulationoftransmembranetransporteractivityvasodilationwoundhealing
Adhesion G protein-coupled receptor L3
2.0
50
88
AGRL3AGRL3Q9HAR2Q9HAR2adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaybraindevelopmentcellsurfacereceptorsignalingpathwaycell-celladhesionviaplasma-membraneadhesionmoleculesGprotein-coupledreceptorsignalingpathwayneuronmigrationsynapseassembly
Beta-1,4-galactosyltransferase 7
2.0
60
86
B4GT7B4GT7Q9UBV7Q9UBV7carbohydratemetabolicprocessglycosaminoglycanbiosyntheticprocessglycosaminoglycanmetabolicprocessglycosylationnegativeregulationoffibroblastproliferationproteinmodificationprocessproteinN-linkedglycosylationproteoglycanbiosyntheticprocessproteoglycanmetabolicprocesssupramolecularfiberorganization
T-cell surface antigen CD2
2.0
45
88
CD2CD2P06729P06729apoptoticprocesscellsurfacereceptorsignalingpathwaycell-celladhesionheterotypiccell-celladhesionmembraneraftpolarizationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitypositiveregulationofinterleukin-8productionpositiveregulationofmyeloiddendriticcellactivationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionregulationofTcelldifferentiationTcellactivation
GDNF family receptor alpha-2
2.0
53
87
GFRA2GFRA2O00451O00451nervoussystemdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Serine protease inhibitor Kazal-type 2
2.0
nan
86
ISK2ISK2P20155P20155acrosomeassemblynegativeregulationofserine-typeendopeptidaseactivityspermatiddevelopment
Insulin-like growth factor-binding protein 6
2.0
27
88
IBP6IBP6P24592P24592cellmigrationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationpositiveregulationofMAPKcascadepositiveregulationofstress-activatedMAPKcascaderegulationofinsulin-likegrowthfactorreceptorsignalingpathwaysignaltransduction
Group 10 secretory phospholipase A2
2.0
46
85
PA2GXPA2GXO15496O15496arachidonicacidmetabolicprocessarachidonicacidsecretionaxonguidancecellularresponsetoleukemiainhibitoryfactorcholesterolhomeostasisdefenseresponsetoviruserythrocytematurationfertilizationhairfolliclemorphogenesisintestinalstemcellhomeostasislow-densitylipoproteinparticleremodelinglysophospholipidtransportmacrophageactivationnegativeregulationofcholesteroleffluxnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinflammatoryresponsephosphatidicacidmetabolicprocessphosphatidylcholinecatabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminemetabolicprocessphosphatidylglycerolmetabolicprocessphosphatidylserinemetabolicprocessphospholipidmetabolicprocessplateletactivatingfactorcatabolicprocesspositiveregulationofacrosomereactionpositiveregulationofarachidonicacidsecretionpositiveregulationoflipidstoragepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofprostaglandinsecretionpositiveregulationofproteinmetabolicprocessproductionofmolecularmediatorinvolvedininflammatoryresponseprostaglandinbiosyntheticprocessregulationofmacrophageactivation
Killer cell immunoglobulin-like receptor 2DL3
2.0
85
82
KI2L3KI2L3P43628P43628immuneresponse
Gastricsin
2.0
60
88
PEPCPEPCP20142P20142digestionpositiveregulationofantibacterialpeptideproductionproteolysis
T-cell surface glycoprotein CD5
2.0
58
87
CD5CD5P06127P06127apoptoticsignalingpathwaycellrecognitionTcellcostimulation
Interleukin-10
2.0
41
88
IL10IL10P22301P22301agingBcelldifferentiationBcellproliferationbranchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoestradiolstimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetolipopolysaccharidechronicinflammatoryresponsetoantigenicstimuluscytoplasmicsequesteringofNF-kappaBdefenseresponsetobacteriumdefenseresponsetoprotozoanendothelialcellapoptoticprocesshemopoiesisleukocytechemotaxisliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofBcellproliferationnegativeregulationofcellpopulationproliferationnegativeregulationofchemokine(C-Cmotif)ligand5productionnegativeregulationofchronicinflammatoryresponsetoantigenicstimulusnegativeregulationofcytokineactivitynegativeregulationofcytokineproductionnegativeregulationofcytokineproductioninvolvedinimmuneresponsenegativeregulationofheterotypiccell-celladhesionnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofinflammatoryresponsenegativeregulationofinterferon-alphaproductionnegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-18productionnegativeregulationofinterleukin-6productionnegativeregulationofinterleukin-8productionnegativeregulationofmembraneproteinectodomainproteolysisnegativeregulationofMHCclassIIbiosyntheticprocessnegativeregulationofmitoticcellcyclenegativeregulationofmyeloiddendriticcellactivationnegativeregulationofneuronapoptoticprocessnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofsensoryperceptionofpainnegativeregulationofTcellproliferationnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofBcellapoptoticprocesspositiveregulationofcellcyclepositiveregulationofcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellproliferationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofimmunoglobulinproductionpositiveregulationofmacrophageactivationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofplasmacelldifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsignalingreceptoractivitypositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularassociatedsmoothmusclecellproliferationregulationofgeneexpressionregulationofisotypeswitchingregulationofresponsetowoundingregulationofsynapseorganizationresponsetoactivityresponsetocarbonmonoxideresponsetoglucocorticoidresponsetoinactivityresponsetoinsulinresponsetomoleculeofbacterialoriginresponsetoxenobioticstimulustype2immuneresponse
Lysosomal protective protein
2.0
48
87
PPGBPPGBP10619P10619intracellularproteintransportnegativeregulationofchaperone-mediatedautophagyproteolysisregulationofchaperone-mediatedautophagyregulationofproteinstability
HLA class II histocompatibility antigen DR beta chain
2.0
81
79
Q5Y7D1Q5Y7D1Q5Y7D1Q5Y7D1adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Prolactin-inducible protein
2.0
63
82
PIPPIPP12273P12273detectionofchemicalstimulusinvolvedinsensoryperceptionofbittertastenegativeregulationofTcellapoptoticprocesspositiveregulationofgeneexpressionproteolysisregulationofimmunesystemprocessretinahomeostasis
Prion-like protein doppel
2.0
52
89
PRNDPRNDQ9UKY0Q9UKY0acrosomereactioncellularcopperionhomeostasisproteinhomooligomerization
Natural cytotoxicity triggering receptor 1
2.0
80
83
NCTR1NCTR1O76016O76016cellulardefenseresponsenaturalkillercellactivationregulationofnaturalkillercellmediatedcytotoxicitysignaltransduction
Lithostathine-1-alpha
2.0
nan
87
REG1AREG1AP05451P05451antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellwalldisruptioninanotherorganismpositiveregulationofcellpopulationproliferationresponsetopeptidehormone
Bone morphogenetic protein receptor type-2
2.0
72
83
BMPR2BMPR2Q4ZG08Q4ZG08anterior/posteriorpatternspecificationaorticvalvedevelopmentarterydevelopmentatrialseptummorphogenesisbloodvesseldevelopmentbloodvesselremodelingBMPsignalingpathwaycellularresponsetoBMPstimuluscellularresponsetogrowthfactorstimuluscellularresponsetostarvationchondrocytedevelopmentendocardialcushiondevelopmentendochondralbonemorphogenesisendothelialcellapoptoticprocessendothelialcellproliferationlimbdevelopmentlungalveolusdevelopmentlymphangiogenesislymphaticendothelialcelldifferentiationmaternalplacentadevelopmentmesodermformationmitralvalvemorphogenesisnegativeregulationofcellgrowthnegativeregulationofcellproliferationinvolvedinheartvalvemorphogenesisnegativeregulationofchondrocyteproliferationnegativeregulationofDNAbiosyntheticprocessnegativeregulationofmusclecelldifferentiationnegativeregulationofsmoothmusclecellproliferationnegativeregulationofsystemicarterialbloodpressurenegativeregulationofvasoconstrictionosteoblastdifferentiationoutflowtractmorphogenesisoutflowtractseptummorphogenesispharyngealarcharterymorphogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofBMPsignalingpathwaypositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofossificationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationproteoglycanbiosyntheticprocesspulmonaryvalvedevelopmentregulationofcellpopulationproliferationregulationoflungbloodpressureretinavasculaturedevelopmentincamera-typeeyesemi-lunarvalvedevelopmenttransmembranereceptorproteinserine/threoninekinasesignalingpathwaytricuspidvalvemorphogenesisvenousbloodvesseldevelopmentventricularseptummorphogenesis
Leucocyte antigen
2.0
81
83
O19075O19075O19075O19075antigenprocessingandpresentationimmuneresponse
Calcitonin receptor
2.0
59
86
CALCRCALCRP30988P30988adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwaycellsurfacereceptorsignalingpathwaycross-receptorinhibitionwithinGprotein-coupledreceptorheterodimerpositiveregulationofadenylatecyclaseactivitypositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcelldeathpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingresponsetoamyloid-betaresponsetoglucocorticoid
Amyloid-beta precursor protein
2.0
54
88
A4A4P05067P05067adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehavioramyloidfibrilformationantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideassociativelearningastrocyteactivationastrocyteactivationinvolvedinimmuneresponseaxo-dendritictransportaxonmidlinechoicepointrecognitionaxonogenesiscalcium-mediatedsignalingcelladhesioncellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocAMPcellularresponsetocopperioncellularresponsetomanganeseioncellularresponsetonervegrowthfactorstimuluscellularresponsetonorepinephrinestimuluscentralnervoussystemdevelopmentcholesterolmetabolicprocesscognitioncollateralsproutinginabsenceofinjurydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdendritedevelopmentendocytosisextracellularmatrixorganizationforebraindevelopmentGprotein-coupledreceptorsignalingpathwayG2/MtransitionofmitoticcellcycleinnateimmuneresponseionotropicglutamatereceptorsignalingpathwaylearninglearningormemorylipoproteinmetabolicprocesslocomotorybehaviormatingbehaviormemorymicrogliadevelopmentmicroglialcellactivationmodulationofexcitatorypostsynapticpotentialmRNApolyadenylationnegativeregulationofbloodcirculationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofmitochondrionorganizationnegativeregulationofneurondeathnegativeregulationofneurondifferentiationnegativeregulationofpeptidaseactivitynegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwayneuromuscularprocesscontrollingbalanceneuronapoptoticprocessneuroncellularhomeostasisneuronprojectiondevelopmentneuronprojectionmaintenanceneuronremodelingNotchsignalingpathwaypositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofamyloidfibrilformationpositiveregulationofapoptoticprocesspositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcellactivationpositiveregulationofchemokineproductionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGprotein-coupledreceptorinternalizationpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhistoneacetylationpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationoflong-termsynapticdepressionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinimportpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorbindingpositiveregulationofresponsetoendoplasmicreticulumstresspositiveregulationofsuperoxideaniongenerationpositiveregulationofTcellmigrationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionproteinhomooligomerizationproteinphosphorylationproteintetramerizationproteintrimerizationregulationofacetylcholine-gatedcationchannelactivityregulationofamyloidfibrilformationregulationofamyloid-betaclearanceregulationofdendriticspinemaintenanceregulationofepidermalgrowthfactor-activatedreceptoractivityregulationofgeneexpressionregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofmulticellularorganismgrowthregulationofNMDAreceptoractivityregulationofpeptidyl-tyrosinephosphorylationregulationofpresynapseassemblyregulationofproteintyrosinekinaseactivityregulationofresponsetocalciumionregulationofsignalingreceptoractivityregulationofspontaneoussynaptictransmissionregulationofsynapsestructureoractivityregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftranslationregulationofWntsignalingpathwayresponsetointerleukin-1responsetoleadionresponsetooxidativestressresponsetoyeastsmoothendoplasmicreticulumcalciumionhomeostasissucklingbehaviorsynapseorganizationsynapticassemblyatneuromuscularjunctionvisuallearning
Meprin A subunit alpha
2.0
50
87
MEP1AMEP1AQ16819Q16819epidermalgrowthfactorreceptorligandmaturationsignalingreceptorligandprecursorprocessing
Sodium channel protein type 10 subunit alpha
2.0
64
86
SCNAASCNAAQ9Y5Y9Q9Y5Y9AVnodecellactionpotentialbundleofHiscellactionpotentialmembranedepolarizationduringactionpotentialneuronalactionpotentialodontogenesisofdentin-containingtoothregulationofatrialcardiacmusclecellmembranedepolarizationregulationofcardiacmusclecontractionregulationofheartrateregulationofiontransmembranetransportsensoryperceptionsensoryperceptionofpainsodiumiontransmembranetransport
Stanniocalcin-2
2.0
nan
94
STC2STC2O76061O76061cellularcalciumionhomeostasiscellularresponsetohypoxiadecidualizationembryoimplantationendoplasmicreticulumunfoldedproteinresponsenegativeregulationofgeneexpressionnegativeregulationofmulticellularorganismgrowthregulationofhormonebiosyntheticprocessregulationofstore-operatedcalciumentryresponsetooxidativestressresponsetopeptidehormoneresponsetovitaminD
Hepatitis A virus cellular receptor 1
2.0
69
83
HAVR1HAVR1Q96D42Q96D42phagocytosisengulfmentpositiveregulationofmastcellactivation
Transcobalamin-2
2.0
69
85
TCO2TCO2P20062P20062cobalamintransportcobaltiontransport
Nectin cell adhesion molecule 1
2.0
69
83
F1MQJ3F1MQJ3F1MQJ3F1MQJ3desmosomeorganizationenamelmineralizationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomophiliccelladhesionviaplasmamembraneadhesionmoleculesironiontransportlensmorphogenesisincamera-typeeyeproteinlocalizationtocelljunctionretinadevelopmentincamera-typeeye
Integrin beta-1
2.0
nan
91
ITB1ITB1P05556P05556axonextensionBcelldifferentiationbasementmembraneorganizationcalcium-independentcell-matrixadhesioncardiaccellfatespecificationcardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationCD40signalingpathwaycelladhesioncelladhesionmediatedbyintegrincellmigrationcellmigrationinvolvedinsproutingangiogenesiscellprojectionorganizationcell-celladhesionmediatedbyintegrincell-matrixadhesioncell-substrateadhesioncellulardefenseresponsecellularresponsetolow-densitylipoproteinparticlestimulusdendritemorphogenesisestablishmentofmitoticspindleorientationformationofradialglialscaffoldsG1/Stransitionofmitoticcellcyclegermcellmigrationheterotypiccell-celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinuteroembryonicdevelopmentintegrin-mediatedsignalingpathwaylamellipodiumassemblyleukocytecell-celladhesionleukocytetetheringorrollingmaintenanceofblood-brainbarriermesodermalcelldifferentiationmuscleorgandevelopmentmyoblastdifferentiationmyoblastfatespecificationmyoblastfusionnegativeregulationofanoikisnegativeregulationofneurondifferentiationnegativeregulationofRhoproteinsignaltransductionneuroblastproliferationphagocytosispositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofcellmigrationpositiveregulationoffibroblastmigrationpositiveregulationofglutamateuptakeinvolvedintransmissionofnerveimpulsepositiveregulationofGTPaseactivitypositiveregulationofneuroblastproliferationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofsignalingreceptoractivitypositiveregulationofwoundhealingreactivegliosisreceptorinternalizationregulationofcellcycleregulationofcollagencatabolicprocessregulationofinwardrectifierpotassiumchannelactivityregulationofspontaneoussynaptictransmissionregulationofsynapsepruningsarcomereorganizationvisuallearningwoundhealingspreadingofepidermalcells
Inactive pancreatic lipase-related protein 1
2.0
57
87
LIPR1LIPR1P54315P54315lipidmetabolicprocess
Signal-regulatory protein gamma
2.0
82
81
SIRPGSIRPGQ9P1W8Q9P1W8celladhesioncell-cellsignalingintracellularsignaltransductionnegativeregulationofcellpopulationproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-celladhesionpositiveregulationofphagocytosispositiveregulationofTcellactivation
Neurexin-1
2.1
57
89
NRX1ANRX1AQ28146Q28146celladhesion
Beta-2-glycoprotein 1
2.0
55
89
APOHAPOHP02749P02749bloodcoagulationintrinsicpathwaynegativeregulationofangiogenesisnegativeregulationofbloodcoagulationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationnegativeregulationoffibrinolysisnegativeregulationofmyeloidcellapoptoticprocessnegativeregulationofsmoothmusclecellapoptoticprocessplasminogenactivationpositiveregulationofbloodcoagulationpositiveregulationoflipoproteinlipaseactivityregulationoffibrinolysistriglyceridemetabolicprocesstriglyceridetransport
ICOS ligand
2.0
78
81
ICOSLICOSLO75144O75144adaptiveimmuneresponseBcellactivationdefenseresponsehyperosmoticresponsepositiveregulationofactivatedTcellproliferationregulationofcytokineproductionsignaltransductionTcellactivationTcellreceptorsignalingpathway
Frizzled-10
2.1
55
88
FZD10FZD10Q9ULW2Q9ULW2canonicalWntsignalingpathwaycellularresponsetoretinoicacidnegativeregulationofGTPaseactivityneurondifferentiationnon-canonicalWntsignalingpathwayviaJNKcascadepositiveregulationofGTPaseactivitypositiveregulationofJUNkinaseactivityregulationofactincytoskeletonorganization
Sodium leak channel NALCN
2.0
62
85
NALCNNALCNQ6Q760Q6Q760calciumiontransmembranetransportpositiveregulationofsynaptictransmissioncholinergicpositiveregulationofsynaptictransmissionGABAergicpotassiumiontransmembranetransportregulationofiontransmembranetransportregulationofrestingmembranepotentialsodiumiontransmembranetransport
Angiotensin-converting enzyme
2.2
46
83
A0A7J7V5I6A0A7J7V5I6A0A7J7V5I6A0A7J7V5I6proteolysis
Thyroglobulin
2.0
nan
94
THYGTHYGP01267P01267hormonebiosyntheticprocessthyroidhormonegeneration
Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, isoform CRA_e
2.0
50
89
D3DQ39D3DQ39D3DQ39D3DQ39endocytosis
ENSMUSG00000076577 protein
2.0
95
79
Q52L64Q52L64Q52L64Q52L64immuneresponse
Serine protease inhibitor Kazal-type 5
2.0
60
87
ISK5ISK5Q9NQ38Q9NQ38celldifferentiationcentralnervoussystemdevelopmentepidermalcelldifferentiationepithelialcelldifferentiationextracellularmatrixorganizationhaircelldifferentiationnegativeregulationofangiogenesisnegativeregulationofantibacterialpeptideproductionnegativeregulationofimmuneresponsenegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofserine-typepeptidaseactivityregulationofcelladhesionregulationofTcelldifferentiationregulationoftimingofanagen
U2 small nuclear ribonucleoprotein A'
2.0
77
81
RU2ARU2AP09661P09661mRNAsplicingviaspliceosomeRNAsplicingspermatogenesisU2-typeprespliceosomeassembly
Mature alpha chain of major histocompatibility complex class I antigen
2.1
80
82
Q95565Q95565Q95565Q95565antigenprocessingandpresentationimmuneresponse
Vascular endothelial growth factor receptor 2
3.0
nan
94
VGFR2VGFR2P35968P35968angiogenesisbloodvesselendothelialcelldifferentiationbranchinginvolvedinbloodvesselmorphogenesiscalciumionhomeostasiscalcium-mediatedsignalingusingintracellularcalciumsourcecellfatecommitmentcellmigrationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohydrogensulfidecellularresponsetovascularendothelialgrowthfactorstimulusembryonichemopoiesisendocardiumdevelopmentendothelialcelldifferentiationendotheliumdevelopmentepithelialcellmaturationepithelialcellproliferationERK1andERK2cascadehematopoieticprogenitorcelldifferentiationlungalveolusdevelopmentlymphvesseldevelopmentmesenchymalcellproliferationnegativeregulationofapoptoticprocessnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocessovarianfollicledevelopmentpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofBMPsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofkinaseactivitypositiveregulationofmacroautophagypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmitochondrialdepolarizationpositiveregulationofmitochondrialfissionpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofpositivechemotaxispositiveregulationofproteinphosphorylationpositiveregulationofstemcellproliferationpositiveregulationofvasculogenesispost-embryoniccamera-typeeyemorphogenesisproteinautophosphorylationproteinkinaseBsignalingregulationofbonedevelopmentregulationofcellshaperegulationofhematopoieticprogenitorcelldifferentiationregulationofMAPKcascadesemaphorin-plexinsignalingpathwaystemcellproliferationsurfactanthomeostasistransmembranereceptorproteintyrosinekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesis
Immunoglobulin iota chain
2.0
84
80
VPREBVPREBP12018P12018immuneresponse
Tumor necrosis factor receptor superfamily member 10B
2.0
53
89
TR10BTR10BO14763O14763activationofNF-kappaB-inducingkinaseactivityapoptoticprocesscellsurfacereceptorsignalingpathwaycellularresponsetomechanicalstimulusdefenseresponsetotumorcellextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresspositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingregulationofapoptoticprocessresponsetoendoplasmicreticulumstressTRAIL-activatedapoptoticsignalingpathway
Thrombopoietin
2.1
nan
94
TPOTPOP40225P40225cellpopulationproliferationcellularresponsetolipopolysaccharidemegakaryocytedevelopmentmegakaryocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofhematopoieticstemcellproliferationpositiveregulationofMAPKcascadepositiveregulationofmegakaryocytedifferentiationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationreceptorsignalingpathwayviaSTATthrombopoietin-mediatedsignalingpathway
Granzyme B
2.0
69
83
✔
GRABGRABP10144P10144apoptoticprocesscytolysisgranzyme-mediatedprogrammedcelldeathsignalingpathwaynaturalkillercellmediatedcytotoxicitynegativeregulationoftranslationpositiveregulationofproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwayproteolysisinvolvedinproteincatabolicprocesspyroptosis
Protein S100-A10
2.0
42
85
✔
S10AAS10AAP60903P60903membraneraftassemblymRNAtranscriptionbyRNApolymeraseIIpositiveregulationofbindingpositiveregulationofexocytosispositiveregulationoffocaladhesionassemblypositiveregulationofGTPaseactivitypositiveregulationofplasmamembranerepairpositiveregulationofplasminogenactivationpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtoplasmamembraneregulationofneurogenesisvesiclebuddingfrommembrane
Tumor necrosis factor receptor superfamily member 4
2.0
nan
94
TNR4TNR4P43489P43489immuneresponseinflammatoryresponsenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionpositiveregulationofBcellproliferationpositiveregulationofimmunoglobulinproductionTcellproliferation
Bone morphogenetic protein type II receptor
2.0
59
85
Q91WY9Q91WY9Q91WY9Q91WY9
Major allergen beta-lactoglobulin
2.0
52
87
B5B0D4B5B0D4B5B0D4B5B0D4
Ig-like domain-containing protein
2.1
81
80
Q9D8L4Q9D8L4Q9D8L4Q9D8L4
Ephrin-B2
2.0
76
83
EFNB2EFNB2P52799P52799adherensjunctionorganizationanatomicalstructuremorphogenesisanimalorganmorphogenesisaxonguidancebloodvesselmorphogenesiscelladhesioncellmigrationinvolvedinsproutingangiogenesiscell-cellsignalingcellularresponsetolipopolysaccharideephrinreceptorsignalingpathwaykeratinocyteproliferationlymphvesseldevelopmentnegativeregulationofkeratinocyteproliferationnegativeregulationofneuronprojectiondevelopmentnephricductmorphogenesispositiveregulationofaortamorphogenesispositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofneurondeathpresynapseassemblyregulationofchemotaxisregulationofpostsynapticmembraneneurotransmitterreceptorlevelsregulationofpostsynapticneurotransmitterreceptorinternalizationTcellcostimulationvenousbloodvesselmorphogenesis
Plexin-A2
2.0
44
90
PLXA2PLXA2P70207P70207cellsurfacereceptorsignalingpathwaycentrosomelocalizationcerebellargranulecellprecursortangentialmigrationlimbbudformationnegativeregulationofcelladhesionneuraltubedevelopmentpharyngealsystemdevelopmentpositiveregulationofaxonogenesisregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivitysemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesomitogenesis
Protein patched homolog 1
2.0
73
82
PTC1PTC1Q61115Q61115animalorganmorphogenesisbraindevelopmentbranchinginvolvedinuretericbudmorphogenesiscelldifferentiationinvolvedinkidneydevelopmentcellfatedeterminationcellproliferationinvolvedinmetanephrosdevelopmentcellularresponsetocholesterolcommissuralneuronaxonguidancedorsal/ventralneuraltubepatterningdorsal/ventralpatternformationembryoniclimbmorphogenesisembryonicorgandevelopmentepidermalcellfatespecificationepidermisdevelopmentepithelialcellproliferationglucosehomeostasisheartmorphogenesishindlimbmorphogenesisinuteroembryonicdevelopmentkeratinocyteproliferationlimbmorphogenesisliverregenerationmammaryglanddevelopmentmammaryglandductmorphogenesismammaryglandepithelialcelldifferentiationmetanephriccollectingductdevelopmentnegativeregulationofcelldivisionnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationnegativeregulationofkeratinocyteproliferationnegativeregulationofmulticellularorganismgrowthnegativeregulationofosteoblastdifferentiationnegativeregulationofsmoothenedsignalingpathwaynegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIneuralplateaxisspecificationneuraltubeclosureneuraltubeformationneuraltubepatterningpatternspecificationprocesspharyngealsystemdevelopmentpositiveregulationofcholesteroleffluxpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepidermalcelldifferentiationprostateglanddevelopmentproteinlocalizationtoplasmamembraneproteinprocessingregulationofcellpopulationproliferationregulationofgrowthregulationofmitoticcellcycleregulationofproteinlocalizationresponsetochlorateresponsetoestradiolresponsetomechanicalstimulusresponsetoretinoicacidresponsetoxenobioticstimulussignaltransductionsmoothmuscletissuedevelopmentsomitedevelopmentspermatiddevelopmentspinalcordmotorneurondifferentiationstemcellproliferation
Immunoglobulin alpha Fc receptor
2.0
79
82
FCARFCARP24071P24071cellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetointerferon-alphacellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonFcreceptorsignalingpathwayimmuneresponseneutrophilactivationneutrophilmediatedimmunitypositiveregulationofneutrophilapoptoticprocesspositiveregulationofoxidativestress-inducedcelldeath
TP53-regulated inhibitor of apoptosis 1
2.0
52
84
TRIA1TRIA1O43715O43715apoptoticprocesscellularresponsetoUVDNAdamageresponsesignaltransductionbyp53classmediatorDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestintermembranelipidtransfernegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofreleaseofcytochromecfrommitochondriaphospholipidtranslocationphospholipidtransportpositiveregulationofphospholipidtransportpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofmembranelipiddistribution
Opioid-binding protein/cell adhesion molecule
2.0
75
83
OPCMOPCMQ14982Q14982celladhesionneuronrecognition
Volume-regulated anion channel subunit LRRC8D
2.0
81
82
LRC8DLRC8DQ7L1W4Q7L1W4aniontransmembranetransportaspartatetransmembranetransportcellularglucosehomeostasiscellularresponsetoosmoticstressproteinhexamerizationtaurinetransport
5'-nucleotidase
2.0
52
86
Q53Z63Q53Z63Q53Z63Q53Z63nucleotidecatabolicprocess
Cytotoxic T-lymphocyte protein 4
2.0
53
86
F6ZMI5F6ZMI5F6ZMI5F6ZMI5BcellreceptorsignalingpathwaycellularresponsetoDNAdamagestimulusimmuneresponsenegativeregulationofBcellproliferationnegativeregulationofregulatoryTcelldifferentiationpositiveregulationofapoptoticprocessregulationofTcellproliferationTcellreceptorsignalingpathway
receptor protein-tyrosine kinase
2.0
76
82
Q8NI16Q8NI16Q8NI16Q8NI16positiveregulationofcellpopulationproliferation
Kallikrein-4
2.0
64
84
KLK4KLK4Q9Y5K2Q9Y5K2amelogenesisbiomineraltissuedevelopmentextracellularmatrixdisassemblyproteolysis
Muscle, skeletal receptor tyrosine protein kinase
2.0
63
84
MUSKMUSKQ62838Q62838celldifferentiationcochleadevelopmentlong-termsynapticpotentiationmemorymotorneuronapoptoticprocessnegativeregulationofgeneexpressionneuromuscularjunctiondevelopmentpositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofmotorneuronapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteingeranylgeranylationpositiveregulationofproteinphosphorylationpositiveregulationofskeletalmuscleacetylcholine-gatedchannelclusteringpositiveregulationofsynapticassemblyatneuromuscularjunctionpositiveregulationofsynaptictransmissioncholinergicproteinautophosphorylationreceptorclusteringregulationofDNA-templatedtranscriptionregulationofsynapticassemblyatneuromuscularjunctionresponsetoaxoninjuryresponsetoelectricalstimulusresponsetomuscleactivityretinadevelopmentincamera-typeeyeskeletalmuscleacetylcholine-gatedchannelclusteringtransmembranereceptorproteintyrosinekinasesignalingpathway
Serine peptidase inhibitor, Kunitz type 1
2.0
63
87
H3BR01H3BR01H3BR01H3BR01
Cocaine- and amphetamine-regulated transcript protein
2.0
54
87
CARTCARTQ16568Q16568adultfeedingbehaviorcell-cellsignalingcellularglucosehomeostasiscellularresponsetostarvationchemicalsynaptictransmissioncircadianregulationofgeneexpressionGprotein-coupledreceptorsignalingpathwaynegativeregulationofappetitenegativeregulationofboneresorptionnegativeregulationofglucagonsecretionnegativeregulationofosteoclastdifferentiationneuropeptidesignalingpathwaypositiveregulationofbloodpressurepositiveregulationofepinephrinesecretionpositiveregulationofMAPKcascadepositiveregulationofproteinkinaseactivitypositiveregulationoftransmissionofnerveimpulseregulationofinsulinsecretionsignaltransductionsomatostatinsecretion
Leucine-rich repeats and immunoglobulin-like domains protein 1
2.0
nan
91
LRIG1LRIG1Q96JA1Q96JA1haircycleprocessinnervationotolithmorphogenesissensoryperceptionofsound
Eosinophil cationic protein
2.0
64
88
ECPECPP12724P12724antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidechemotaxisdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminductionofbacterialagglutinationinnateimmuneresponseinnateimmuneresponseinmucosaRNAcatabolicprocess
Tumor necrosis factor receptor superfamily member 5
2.0
40
90
TNR5TNR5P25942P25942BcellactivationBcellmediatedimmunityBcellproliferationCD40signalingpathwaycellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetomechanicalstimuluscellularresponsetotumornecrosisfactordefenseresponsetoprotozoandefenseresponsetovirusimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinflammatoryresponseplateletactivationpositiveregulationofangiogenesispositiveregulationofBcellproliferationpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-12productionpositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofMAPkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinproteinkinaseBsignalingprotein-containingcomplexassemblyresponsetotypeIIinterferonTRIF-dependenttoll-likereceptorsignalingpathway
Ig-like domain-containing protein
2.0
90
80
Q6GMX0Q6GMX0Q6GMX0Q6GMX0
Glucosidase 2 subunit beta
2.0
50
89
GLU2BGLU2BP14314P14314intracellularsignaltransductionliverdevelopmentN-glycanprocessing
Neuropilin-2
2.1
50
88
NRP2NRP2O60462O60462angiogenesisaxonextensioninvolvedinaxonguidanceaxonguidancecelladhesioncellularresponsetoleukemiainhibitoryfactordorsalrootganglionmorphogenesisfacialnervestructuralorganizationfacioacousticgangliondevelopmentgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamusnegativechemotaxisnervedevelopmentneuralcrestcellmigrationinvolvedinautonomicnervoussystemdevelopmentoutflowtractseptummorphogenesispositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationregulationofpostsynapseorganizationsemaphorin-plexinsignalingpathwayinvolvedinneuronprojectionguidancesensoryneuronaxonguidancesympatheticgangliondevelopmentsympatheticneuronprojectionextensionsympatheticneuronprojectionguidancetrigeminalgangliondevelopmentventraltrunkneuralcrestcellmigrationvestibulocochlearnervestructuralorganization
Alpha-N-acetylgalactosaminidase
2.0
50
85
NAGABNAGABP17050P17050carbohydratecatabolicprocessglycolipidcatabolicprocessglycosidecatabolicprocessoligosaccharidemetabolicprocess
Inhibin beta B chain
2.0
49
88
INHBBINHBBP09529P09529activinreceptorsignalingpathwayapoptoticsignalingpathwaycelldifferentiationcellularresponsetocalciumioncellularresponsetocAMPcellularresponsetocholesterolcellularresponsetoinsulinstimuluscellularresponsetointerleukin-1cellularresponsetoleptinstimuluscellularresponsetostarvationcellularresponsetoThyroglobulintriiodothyroninecellularresponsetothyroidhormonestimulusdefenseresponsefatcelldifferentiationmulticellularorganismagingnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofhepatocytegrowthfactorproductionnegativeregulationofinsulinsecretionoocytedevelopmentovarianfollicledevelopmentpituitaryglanddevelopmentpositiveregulationofapoptoticsignalingpathwaypositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationresponsetogonadotropinresponsetoinsecticideresponsetowoundingseminiferoustubuledevelopmentSMADproteinsignaltransductionspermatogenesis
Regenerating islet-derived protein 4
2.0
44
86
REG4REG4Q9BYZ8Q9BYZ8responsetobacterium
HLA class II histocompatibility antigen, DR beta 5 chain
2.0
80
79
DRB5DRB5Q30126Q30126adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
Urokinase-type plasminogen activator
2.0
63
85
UROKUROKP00749P00749bloodcoagulationchemotaxisfibrinolysisnegativeregulationoffibrinolysisnegativeregulationofplasminogenactivationplasminogenactivationpositiveregulationofcellmigrationproteolysisregulationofcelladhesionregulationofcelladhesionmediatedbyintegrinregulationofcellpopulationproliferationregulationoffibrinolysisregulationofplasminogenactivationregulationofsignalingreceptoractivityregulationofsmoothmusclecellmigrationregulationofsmoothmusclecell-matrixadhesionregulationofwoundhealingresponsetohypoxiasignaltransductionsmoothmusclecellmigrationurokinaseplasminogenactivatorsignalingpathway
Tissue factor pathway inhibitor
2.0
58
87
TFPI1TFPI1P10646P10646bloodcoagulationcellularresponsetosteroidhormonestimulusnegativeregulationofbloodcoagulationnegativeregulationofpeptidaseactivity
MHC class I antigen
2.0
81
83
Q861F6Q861F6Q861F6Q861F6antigenprocessingandpresentationimmuneresponse
MHC class I antigen
2.1
81
82
D9UAY1D9UAY1D9UAY1D9UAY1
Major prion protein
2.0
78
84
Q8VHV5Q8VHV5Q8VHV5Q8VHV5proteinhomooligomerization
Anti-F4+ETEC bacteria VHH variable region
2.0
83
80
R9W2R6R9W2R6R9W2R6R9W2R6
DnaJ homolog subfamily C member 10
2.2
44
88
DJC10DJC10Q9DC23Q9DC23intrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressIRE1-mediatedunfoldedproteinresponsenegativeregulationofproteinphosphorylationpositiveregulationofATP-dependentactivityproteinfoldinginendoplasmicreticulumresponsetoendoplasmicreticulumstressubiquitin-dependentERADpathway
Guanylate cyclase activator 2B
2.0
25
91
GUC2BGUC2BQ16661Q16661cGMP-mediatedsignaling
Activin receptor type-2B
2.0
74
82
AVR2BAVR2BQ3KQI1Q3KQI1activationofproteinkinaseactivityactivinreceptorsignalingpathwayanterior/posteriorpatternspecificationarterydevelopmentbloodvesselremodelingBMPsignalingpathwaycellularresponsetogrowthfactorstimulusdeterminationofleft/rightsymmetryembryonicforegutmorphogenesisgastrulationwithmouthformingsecondheartdevelopmentinsulinsecretionkidneydevelopmentlungdevelopmentlymphangiogenesislymphaticendothelialcelldifferentiationmesodermdevelopmentnegativeregulationofcold-inducedthermogenesisnegativeregulationoftranscriptionbyRNApolymeraseIIodontogenesisofdentin-containingtoothorgangrowthpancreasdevelopmentpatternspecificationprocesspositiveregulationofactivinreceptorsignalingpathwaypositiveregulationofbonemineralizationpositiveregulationofosteoblastdifferentiationpost-embryonicdevelopmentproteinphosphorylationregulationofDNA-templatedtranscriptionregulationofsignaltransductionresponsetoglucoseretinavasculaturedevelopmentincamera-typeeyeroofofmouthdevelopmentsignaltransductionskeletalsystemdevelopmentskeletalsystemmorphogenesisvenousbloodvesseldevelopment
Midkine
2.0
nan
92
MKMKP21741P21741adrenalglanddevelopmentbehavioralfearresponsecelldifferentiationcerebellargranularlayerdevelopmentcerebralcortexdevelopmentcytoskeletonorganizationdefecationdentategyrusdevelopmentestrouscycleglialcellprojectionelongationleukocytechemotaxisinvolvedininflammatoryresponsenegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofcelladhesionnegativeregulationofepithelialcellapoptoticprocessnegativeregulationofinflammatoryresponsetowoundingnegativeregulationofneuronapoptoticprocessnegativeregulationofossificationnegativeregulationofregulatoryTcelldifferentiationnervoussystemdevelopmentoogenesispositiveregulationofarterymorphogenesispositiveregulationofbloodvesselbranchingpositiveregulationofcartilagedevelopmentpositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofhepatocyteproliferationpositiveregulationofinflammatoryresponsepositiveregulationofinflammatoryresponsetowoundingpositiveregulationofinterleukin-12productionpositiveregulationofkeratinocyteproliferationpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofleukocytecell-celladhesionpositiveregulationofleukocytechemotaxispositiveregulationofmacrophagechemotaxispositiveregulationofneuralprecursorcellproliferationpositiveregulationofneuronmigrationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofneutrophilchemotaxispositiveregulationofneutrophilextravasationpositiveregulationofoligodendrocytedifferentiationpositiveregulationofsmoothmusclecellchemotaxispositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcelldifferentiationpositiveregulationofvascularendothelialcellproliferationregulationofactincytoskeletonreorganizationregulationofbehaviorregulationofboneremodelingregulationofchondrocytedifferentiationresponsetoauditorystimulusresponsetoglucocorticoidresponsetowoundingresponsetoxenobioticstimulusshort-termmemorysignaltransductionTcellactivationinvolvedinimmuneresponsetissueregeneration
MHC class II antigen
2.1
82
79
P79552P79552P79552P79552adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Macrophage scavenger receptor types I and II
2.0
50
90
MSREMSREP21757P21757amyloid-betaclearancecellularresponsetoorganiccycliccompoundcholesteroltransportestablishmentoflocalizationincelllipoproteintransportnegativeregulationofgeneexpressionphagocytosisengulfmentplasmalipoproteinparticleclearancepositiveregulationofcholesterolstoragepositiveregulationofmacrophagederivedfoamcelldifferentiationreceptor-mediatedendocytosis
Neurogenic locus notch homolog protein 2
2.0
55
89
NOTC2NOTC2Q04721Q04721animalorganmorphogenesisapoptoticprocessatrialseptummorphogenesisatrioventricularnodedevelopmentaxonguidanceBMPsignalingpathwayboneremodelingcellfatedeterminationcellularresponsetotumorcellcholangiocyteproliferationciliarybodymorphogenesisdefenseresponsetobacteriumembryoniclimbmorphogenesisglomerularcapillaryformationheartloopinghemopoiesishepatocyteproliferationhumoralimmuneresponseinuteroembryonicdevelopmentinflammatoryresponsetoantigenicstimulusintrahepaticbileductdevelopmentleft/rightaxisspecificationmarginalzoneBcelldifferentiationmorphogenesisofanepithelialsheetmulticellularorganismgrowthmyeloiddendriticcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayplacentabloodvesseldevelopmentpodocytedevelopmentpositiveregulationofapoptoticprocesspositiveregulationofBMPsignalingpathwaypositiveregulationofERK1andERK2cascadepositiveregulationofkeratinocyteproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofRasproteinsignaltransductionproximaltubuledevelopmentpulmonaryvalvemorphogenesisregulationofactincytoskeletonreorganizationregulationofosteoclastdevelopmentwoundhealing
Macrophage colony-stimulating factor 1 receptor
2.0
63
85
CSF1RCSF1RP07333P07333axonguidancecellpopulationproliferationcell-celljunctionmaintenancecellularresponsetocytokinestimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluscytokine-mediatedsignalingpathwayforebrainneurondifferentiationhematopoieticprogenitorcelldifferentiationhemopoiesisinflammatoryresponseinnateimmuneresponsemacrophagecolony-stimulatingfactorsignalingpathwaymacrophagedifferentiationmammaryglandductmorphogenesismicroglialcellproliferationmonocytedifferentiationnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationolfactorybulbdevelopmentosteoclastdifferentiationpeptidyl-tyrosinephosphorylationphosphatidylinositolmetabolicprocessphosphatidylinositol-mediatedsignalingpositiveregulationbyhostofviralprocesspositiveregulationofcellmigrationpositiveregulationofcellmotilitypositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofERK1andERK2cascadepositiveregulationofkinaseactivitypositiveregulationofmacrophagechemotaxispositiveregulationofmacrophageproliferationpositiveregulationofproteinphosphorylationpositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofproteintyrosinekinaseactivitypositiveregulationoftyrosinephosphorylationofSTATproteinproteinautophosphorylationregulationofactincytoskeletonreorganizationregulationofboneresorptionregulationofcellshaperegulationofMAPKcascaderesponsetoischemiaruffleorganizationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Histocompatibility 2, T region locus 22
2.0
59
85
Q31615Q31615Q31615Q31615antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIb
C-C motif chemokine 23
2.0
40
88
CCL23CCL23P55773P55773cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisnegativeregulationofC-CchemokinebindingnegativeregulationofcellpopulationproliferationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransduction
Eotaxin
2.0
42
88
CCL11CCL11P51671P51671actinfilamentorganizationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebranchinginvolvedinmammaryglandductmorphogenesiscelladhesioncellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxischronicinflammatoryresponsecytoskeletonorganizationeosinophilchemotaxisERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlearningormemorylymphocytechemotaxismammaryductterminalendbudgrowthmastcellchemotaxismonocytechemotaxisnegativeregulationofneurogenesisneutrophilchemotaxispositiveregulationofactinfilamentpolymerizationpositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivityproteinphosphorylationregulationofcellshaperesponsetointerleukin-13responsetointerleukin-4responsetoradiationresponsetovirussignaltransduction
Interleukin-4 receptor subunit alpha
2.0
71
86
IL4RAIL4RAP24394P24394cytokine-mediatedsignalingpathwaydefenseresponsetoprotozoanimmuneresponseimmunoglobulinmediatedimmuneresponsenegativeregulationofT-helper1celldifferentiationovulationpositiveregulationofchemokineproductionpositiveregulationofcold-inducedthermogenesispositiveregulationofimmunoglobulinproductionpositiveregulationofmacrophageactivationpositiveregulationofmastcelldegranulationpositiveregulationofmyoblastfusionpositiveregulationofT-helper2celldifferentiationproductionofmolecularmediatorinvolvedininflammatoryresponseregulationofcellpopulationproliferationresponsetoestrogenresponsetoodorantsignaltransductionT-helper1celldifferentiationT-helper2celldifferentiation
Relaxin receptor 1
2.0
34
88
RXFP1RXFP1Q9HBX9Q9HBX9activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayextracellularmatrixorganizationhormone-mediatedsignalingpathwaylungconnectivetissuedevelopmentmyofibroblastdifferentiationnipplemorphogenesisparturition
Serine protease inhibitor Kazal-type 7
2.0
nan
86
ISK7ISK7P58062P58062inflammatoryresponsenegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofpeptidaseactivity
Protein jagged-2
2.0
39
90
JAG2JAG2Q9Y219Q9Y219auditoryreceptorcellfatecommitmentcelldifferentiationepithelialcellapoptoticprocessinvolvedinpalatalshelfmorphogenesisgamma-deltaTcelldifferentiationinuteroembryonicdevelopmentmorphogenesisofembryonicepitheliumNotchsignalingpathwayodontogenesisofdentin-containingtoothpositiveregulationofNotchsignalingpathwayregulationofcelladhesionregulationofcellpopulationproliferationrespiratorysystemprocessskeletalsystemdevelopmentspermatogenesisTcelldifferentiationthymicTcellselection
GDNF family receptor alpha-1
2.0
51
86
O35748O35748O35748O35748cellsurfacereceptorsignalingpathway
Volume-regulated anion channel subunit LRRC8A
2.0
63
86
LRC8ALRC8AQ8IWT6Q8IWT6aniontransmembranetransportaniontransportaspartatetransmembranetransportcellvolumehomeostasiscellularglucosehomeostasischloridetransmembranetransportcyclic-GMP-AMPtransmembraneimportacrossplasmamembranepositiveregulationofinsulinsecretionpositiveregulationofmyoblastdifferentiationpre-Bcelldifferentiationproteinhexamerizationresponsetoosmoticstressspermatogenesistaurinetransport
Nectin-2
2.0
75
82
NECT2NECT2P32507P32507acrosomeassemblyadhesionofsymbionttohostcellpartmorphogenesisciliumorganizationcoreceptor-mediatedvirionattachmenttohostcellcytoskeletonorganizationestablishmentoflocalizationincellestablishmentofmitochondrionlocalizationfertilizationfusionofvirusmembranewithhostplasmamembranehomophiliccelladhesionviaplasmamembraneadhesionmoleculespositiveregulationofimmunoglobulinmediatedimmuneresponsepositiveregulationofmastcellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofTcellreceptorsignalingpathwayregulationofviralentryintohostcellspermmitochondrionorganizationspermatiddevelopmentspermatidnucleusdifferentiationsusceptibilitytonaturalkillercellmediatedcytotoxicitysusceptibilitytoTcellmediatedcytotoxicity
Integrin beta
2.0
nan
89
A0A494C0X7A0A494C0X7A0A494C0X7A0A494C0X7agingcellularextravasationendothelialcellmigrationintegrin-mediatedsignalingpathwayleukocytecell-celladhesionleukocytemigrationinvolvedininflammatoryresponsenaturalkillercellactivationphagocytosispositiveregulationofangiogenesispositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidebiosyntheticprocess
RAC-beta serine/threonine-protein kinase
2.0
37
85
AKT2AKT2P31751P31751activationofGTPaseactivitycarbohydratetransportcellularresponsetohighlightintensitycellularresponsetoinsulinstimulusfatcelldifferentiationglucosemetabolicprocessglycogenbiosyntheticprocessinsulinreceptorsignalingpathwayintracellularproteintransmembranetransportintracellularsignaltransductionmammaryglandepithelialcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationoflong-chainfattyacidimportacrossplasmamembranepeptidyl-serinephosphorylationperipheralnervoussystemmyelinmaintenancepositiveregulationofcellmigrationpositiveregulationofcellmotilitypositiveregulationofcellpopulationproliferationpositiveregulationoffattyacidbeta-oxidationpositiveregulationofglucoseimportpositiveregulationofglucosemetabolicprocesspositiveregulationofglycogenbiosyntheticprocesspositiveregulationofmitochondrialmembranepotentialpositiveregulationofproteinphosphorylationpositiveregulationofproteintargetingtomembranepositiveregulationofvesiclefusionproteinlocalizationtoplasmamembraneproteinmodificationprocessregulationofcellcycleregulationofcellmigrationregulationoftranslationretinalrodcellapoptoticprocesssignaltransduction
Angiogenin
2.0
61
87
Q5WRG2Q5WRG2Q5WRG2Q5WRG2actinfilamentpolymerizationactivationofphospholipaseA2activityactivationofphospholipaseCactivityactivationofproteinkinaseBactivityangiogenesisantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellmigrationdefenseresponsetoGram-positivebacteriumdiacylglycerolbiosyntheticprocessinnateimmuneresponseliverdevelopmentnegativeregulationofsmoothmusclecellproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofphosphorylationpositiveregulationofproteinsecretionresponsetohormoneresponsetohypoxiaresponsetoyeastRNAphosphodiesterbondhydrolysisrRNAtranscription
TGF-beta receptor type-1
2.0
46
87
TGFR1TGFR1P36897P36897activinreceptorsignalingpathwayangiogenesisinvolvedincoronaryvascularmorphogenesisanterior/posteriorpatternspecificationapoptoticprocessarterymorphogenesisblastocystdevelopmentcardiacepithelialtomesenchymaltransitioncellmotilitycellularresponsetogrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimuluscollagenfibrilorganizationcoronaryarterymorphogenesisembryoniccranialskeletonmorphogenesisendothelialcellactivationendothelialcellmigrationendothelialcellproliferationepicardiummorphogenesisepithelialtomesenchymaltransitionextracellularstructureorganizationfilopodiumassemblygermcellmigrationheartdevelopmentinuteroembryonicdevelopmentintracellularsignaltransductionkidneydevelopmentlensdevelopmentincamera-typeeyemalegonaddevelopmentmesenchymalcelldifferentiationnegativeregulationofchondrocytedifferentiationnegativeregulationofendothelialcellproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaynervoussystemdevelopmentneuronfatecommitmentparathyroidglanddevelopmentpathway-restrictedSMADproteinphosphorylationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpharyngealsystemdevelopmentpositiveregulationofapoptoticsignalingpathwaypositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationoffilopodiumassemblypositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofSMADproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationoftightjunctiondisassemblypost-embryonicdevelopmentproteinphosphorylationregulationofcardiacmusclecellproliferationregulationofcellcycleregulationofDNA-templatedtranscriptionregulationofepithelialtomesenchymaltransitionregulationofgeneexpressionregulationofproteinbindingregulationofproteinubiquitinationresponsetocholesterolroofofmouthdevelopmentsignaltransductionskeletalsystemdevelopmentskeletalsystemmorphogenesisthymusdevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayventricularcompactmyocardiummorphogenesisventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
C-C motif chemokine 26
2.0
39
88
CCL26CCL26Q9Y258Q9Y258cell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofactinfilamentpolymerizationpositiveregulationofcellmigrationpositiveregulationofchemotaxispositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransductionTcellchemotaxis
Hepatitis A virus cellular receptor 2
2.0
71
83
HAVR2HAVR2Q8TDQ0Q8TDQ0adaptiveimmuneresponsecellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponsemacrophageactivationinvolvedinimmuneresponsematernalprocessinvolvedinfemalepregnancynaturalkillercelltoleranceinductionnegativeregulationofdefenseresponsetobacteriumnegativeregulationofgeneexpressionnegativeregulationofgranulocytecolony-stimulatingfactorproductionnegativeregulationofimmunologicalsynapseformationnegativeregulationofinterferon-alphaproductionnegativeregulationofinterleukin-2productionnegativeregulationofinterleukin-3productionnegativeregulationofinterleukin-6productionnegativeregulationofmyeloiddendriticcellactivationnegativeregulationofnaturalkillercellactivationnegativeregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcellnegativeregulationofTcellproliferationnegativeregulationofT-helper1typeimmuneresponsenegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionpositiveregulationofchemokineproductionpositiveregulationofdefenseresponsetobacteriumpositiveregulationofERK1andERK2cascadepositiveregulationofinterleukin-1productionpositiveregulationofinterleukin-4productionpositiveregulationofmacrophageactivationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofTcellproliferationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionregulationoftoleranceinductiondependentuponimmuneresponsetoll-likereceptor3signalingpathwaytoll-likereceptor7signalingpathwaytoll-likereceptor9signalingpathway
GDP-fucose protein O-fucosyltransferase 2
2.0
54
85
OFUT2OFUT2Q9Y2G5Q9Y2G5fucosemetabolicprocessmesodermformationpositiveregulationofproteinfoldingproteinO-linkedfucosylationregulationofepithelialtomesenchymaltransitionregulationofgeneexpressionregulationofsecretion
Ephrin type-A receptor 2
2.0
68
88
EPHA2EPHA2P29317P29317activationofGTPaseactivityaxialmesodermformationaxonguidancebloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisboneremodelingbranchinginvolvedinmammaryglandductmorphogenesiscAMPmetabolicprocesscelladhesioncellchemotaxiscellmigrationcellmotilitydefenseresponsetoGram-positivebacteriumephrinreceptorsignalingpathwayinflammatoryresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagekeratinocytedifferentiationlensfibercellmorphogenesismammaryglandepithelialcellproliferationnegativeregulationofangiogenesisnegativeregulationofchemokineproductionnegativeregulationoflymphangiogenesisnegativeregulationofproteinkinaseBsignalingneuraltubedevelopmentnotochordcelldevelopmentnotochordformationosteoblastdifferentiationosteoclastdifferentiationpericytecelldifferentiationpositiveregulationofbicellulartightjunctionassemblypositiveregulationofcellmigrationpositiveregulationofkinaseactivitypositiveregulationofproteinlocalizationtoplasmamembranepost-analtailmorphogenesisproteinkinaseBsignalingproteinlocalizationtoplasmamembraneregulationofangiogenesisregulationofbloodvesselendothelialcellmigrationregulationofcelladhesionmediatedbyintegrinregulationofERK1andERK2cascaderegulationoflamellipodiumassemblyresponsetogrowthfactorskeletalsystemdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayvasculogenesis
Granzyme K
2.0
61
87
GRAKGRAKP49863P49863proteolysis
Interleukin-18 receptor 1
2.0
63
87
IL18RIL18RQ13478Q13478immuneresponseinflammatoryresponseinterleukin-18-mediatedsignalingpathwaynaturalkillercellactivationnegativeregulationofcold-inducedthermogenesisNIK/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofT-helper1cellcytokineproductionpositiveregulationoftypeIIinterferonproductionsignaltransductionT-helper1celldifferentiation
C-C motif chemokine 24
2.0
48
86
CCL24CCL24O00175O00175cell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofactinfilamentpolymerizationpositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofeosinophilmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponseregulationofcellshapesignaltransduction
Gremlin-2
2.0
45
90
GREM2GREM2O88273O88273animalorganmorphogenesiscytokine-mediatedsignalingpathwaydeterminationofdorsalidentityembryonicbodymorphogenesisnegativeregulationofBMPsignalingpathwayregulationofcytokineactivitysequesteringofBMPfromreceptorviaBMPbinding
Natural killer cells antigen CD94
2.0
66
86
KLRD1KLRD1Q13241Q13241adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaynaturalkillercellmediatedimmunitynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellactivationstimulatoryC-typelectinreceptorsignalingpathway
Mitochondrial intermembrane space import and assembly protein 40
2.0
54
84
MIA40MIA40Q8N4Q1Q8N4Q1"denovopost-translationalproteinfolding"mitochondrialrespiratorychaincomplexassemblypeptidyl-cysteineoxidationproteinimportintomitochondrialintermembranespaceproteinmaturationbyproteinfolding
CMRF35-like molecule 1
2.0
55
86
CLM1CLM1Q8TDQ1Q8TDQ1interleukin-13-mediatedsignalingpathwaynegativeregulationofapoptoticcellclearancenegativeregulationofmastcellactivationnegativeregulationofMyD88-dependenttoll-likereceptorsignalingpathwaypositiveregulationofapoptoticcellclearancepositiveregulationofinterleukin-4-mediatedsignalingpathwayTRIF-dependenttoll-likereceptorsignalingpathway
MHC class II antigen
2.0
80
79
I2FL84I2FL84I2FL84I2FL84adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Nociceptin receptor
2.0
65
85
OPRXOPRXP41146P41146adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayconditionedplacepreferenceeatingbehaviorestrouscycleGprotein-coupledopioidreceptorsignalingpathwaynegativeregulationofadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaynegativeregulationofbloodpressurenegativeregulationofcAMP-mediatedsignalingnegativeregulationofvoltage-gatedcalciumchannelactivityneuropeptidesignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofgastricacidsecretionpositiveregulationofsensoryperceptionofpainpositiveregulationofurinevolumeregulationoflocomotorrhythmresponsetoestradiolsensoryperceptionsensoryperceptionofpain
Alpha-2-macroglobulin-like protein 1
2.0
25
90
A2ML1A2ML1A8K2U0A8K2U0negativeregulationofpeptidaseactivityregulationofendopeptidaseactivity
Interleukin-17 receptor C
2.0
50
88
I17RCI17RCQ8NAC3Q8NAC3defenseresponsetofungusgranulocytechemotaxisinflammatoryresponsepositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-6production
Sphingosine 1-phosphate receptor 3
2.0
51
86
S1PR3S1PR3Q99500Q99500adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayanatomicalstructuremorphogenesisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsenegativeregulationofestablishmentofendothelialbarrierNotchsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationregulationofinterleukin-1betaproductionregulationofmetabolicprocess
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
2.0
50
89
LIGO1LIGO1Q96FE5Q96FE5
Protein S100-A7
2.0
54
85
S10A7S10A7P31151P31151angiogenesisantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumepidermisdevelopmentinnateimmuneresponsekeratinocytedifferentiationpositiveregulationofERK1andERK2cascadepositiveregulationofgranulocytechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofTcellchemotaxisresponsetolipopolysaccharideresponsetoreactiveoxygenspeciessequesteringofmetalion
Igh protein
1.8
78
82
Q58E56Q58E56Q58E56Q58E56
Early activation antigen CD69
2.0
55
86
CD69CD69Q07108Q07108cellularresponsetoxenobioticstimulus
Neurofascin
2.0
65
83
NFASCNFASCO94856O94856axonguidancebraindevelopmentcell-celladhesionmyelinationperipheralnervoussystemdevelopmentproteinlocalizationtoplasmamembrane
Tumor necrosis factor-inducible gene 6 protein
2.0
56
88
TSG6TSG6P98066P98066celladhesioncell-cellsignalingfibronectinfibrilorganizationhyaluronanmetabolicprocessinflammatoryresponsenegativeregulationofBMPsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofneutrophilchemotaxisnegativeregulationofosteoblastdifferentiationnegativeregulationofosteoclastdifferentiationovariancumulusexpansionovulationpositiveregulationofcellmigrationpositiveregulationofreceptorclusteringsignaltransduction
CCA tRNA nucleotidyltransferase 1, mitochondrial
2.0
71
80
✔
TRNT1TRNT1Q96Q11Q96Q11ATP"mitochondrialtRNA3-endprocessing""tRNA3-endprocessing""tRNA3-terminalCCAaddition"tRNAprocessing
CD27 antigen
2.0
47
90
CD27CD27P26842P26842cellsurfacereceptorsignalingpathwayextrinsicapoptoticsignalingpathwayimmunoglobulinmediatedimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofTcellapoptoticprocesspositiveregulationofBcelldifferentiationpositiveregulationofJNKcascadepositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofTcelldifferentiationresponsetoethanol
Protein-tyrosine sulfotransferase 2
2.0
71
85
TPST2TPST2O60704O60704"3-phosphoadenosine5-phosphosulfatemetabolicprocess"peptidyl-tyrosinesulfation
E3 ubiquitin-protein ligase RNF43
2.0
45
84
RNF43RNF43Q68DV7Q68DV7negativeregulationofWntsignalingpathwayproteinubiquitinationstemcellproliferationubiquitin-dependentproteincatabolicprocessWntreceptorcatabolicprocessWntsignalingpathway
Frizzled-2
2.0
67
85
FZD2FZD2Q14332Q14332canonicalWntsignalingpathwaycochleamorphogenesisendothelialcelldifferentiationhardpalatedevelopmentinnerearreceptorcelldevelopmentmembranousseptummorphogenesismuscularseptummorphogenesisneurondifferentiationoutflowtractmorphogenesisplanarcellpolaritypathwayinvolvedinneuraltubeclosurepositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionsensoryperceptionofsmellWntsignalingpathwayWntsignalingpathwayplanarcellpolaritypathway
Sortilin-related receptor
2.0
28
91
SORLSORLQ92673Q92673adaptivethermogenesiscellmigrationcellpopulationproliferationdietinducedthermogenesisendosometoplasmamembraneproteintransportinsulinreceptorrecyclingnegativeregulationofamyloid-betaformationnegativeregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofmetalloendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocessnegativeregulationofneurofibrillarytangleassemblynegativeregulationofneurogenesisnegativeregulationofneurondeathnegativeregulationofproteinbindingnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftau-proteinkinaseactivitynegativeregulationoftriglyceridecatabolicprocessneuropeptidesignalingpathwaypositiveregulationofadiposetissuedevelopmentpositiveregulationofcholineO-acetyltransferaseactivitypositiveregulationofearlyendosometorecyclingendosometransportpositiveregulationofendocyticrecyclingpositiveregulationofERtoGolgivesicle-mediatedtransportpositiveregulationofglialcell-derivedneurotrophicfactorproductionpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofproteincatabolicprocesspositiveregulationofproteinexitfromendoplasmicreticulumpositiveregulationofproteinlocalizationtoearlyendosomepost-Golgivesicle-mediatedtransportproteinlocalizationtoGolgiapparatusproteinmaturationproteinretentioninGolgiapparatusproteintargetingproteintargetingtolysosomereceptor-mediatedendocytosisregulationofsmoothmusclecellmigration
Deleted in malignant brain tumors 1 protein
2.0
53
88
DMBT1DMBT1Q9UGM3Q9UGM3antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusdetectionofbacteriallipoproteinepithelialcelldifferentiationinductionofbacterialagglutinationinnateimmuneresponseproteintransportreceptor-mediatedendocytosis
Basigin
2.0
73
82
BASIBASIP35613P35613angiogenesisaxonguidancecellsurfacereceptorsignalingpathwaydecidualizationdendriteself-avoidanceembryoimplantationendothelialtubemorphogenesishomophiliccelladhesionviaplasmamembraneadhesionmoleculesneuralretinadevelopmentneutrophilchemotaxisodontogenesisofdentin-containingtoothphotoreceptorcellmaintenancepositiveregulationofendothelialcellmigrationpositiveregulationofinterleukin-6productionpositiveregulationofmatrixmetallopeptidasesecretionpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofviralentryintohostcellproteinlocalizationtoplasmamembraneresponsetocAMPresponsetomercuryionresponsetopeptidehormone
C-C motif chemokine 4
2.0
74
80
CCL4CCL4P13236P13236celladhesioncell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwayeosinophilchemotaxisestablishmentormaintenanceofcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponselymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviraltranscriptionneutrophilchemotaxispositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellchemotaxisresponsetotoxicsubstanceresponsetovirussignaltransduction
Thrombospondin-2
2.0
52
89
TSP2TSP2P35442P35442celladhesionnegativeregulationofangiogenesispositiveregulationofsynapseassembly
Mitochondrial import inner membrane translocase subunit Tim22
2.0
61
84
TIM22TIM22Q9Y584Q9Y584proteininsertionintomitochondrialinnermembrane
Neural cell adhesion molecule 1
2.0
80
81
NCAM1NCAM1P13596P13596aginganimalorganregenerationaxonalfasciculationbraindevelopmentcalcium-independentcell-celladhesionviaplasmamembranecell-adhesionmoleculescalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoinorganicsubstancecellularresponsetomoleculeofbacterialorigincommissuralneuronaxonguidancehomotypiccell-celladhesionlearningormemorymodulationofchemicalsynaptictransmissionmulticellularorganismalresponsetostressnegativeregulationofcelldeathneurondevelopmentneuronprojectiondevelopmentperipheralnervoussystemaxonregenerationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcardiacmusclecellproliferationregulationofexocystassemblyregulationofsemaphorin-plexinsignalingpathwayregulationofsensoryperceptionofpainresponsetoactivityresponsetococaineresponsetoinorganicsubstanceresponsetoleadionresponsetoxenobioticstimulusthalamusdevelopment
Contactin-1
2.0
74
83
CNTN1CNTN1P12960P12960axonguidancebraindevelopmentcell-celladhesioncentralnervoussystemmyelinformationcerebellumdevelopmentgeneexpressionlocomotorybehaviormyelinationneuronprojectiondevelopmentNotchsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofsodiumiontransport
Neurotrophin-3
2.0
61
87
NTF3NTF3P20783P20783activationofGTPaseactivityactivationofproteinkinaseBactivitycell-cellsignalinginductionofpositivechemotaxismemorymodulationofchemicalsynaptictransmissionnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-tyrosinephosphorylationnervedevelopmentnervegrowthfactorsignalingpathwaynervoussystemdevelopmentneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorinternalizationregulationofapoptoticprocessregulationofneurondifferentiationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
H2-Ab1 protein
2.0
81
79
Q31135Q31135Q31135Q31135adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassII
Complement factor D
2.0
64
85
F6YBP7F6YBP7F6YBP7F6YBP7complementactivationalternativepathwayproteolysisresponsetobacterium
C-X-C motif chemokine 11
2.0
37
88
CXL11CXL11O14625O14625adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaychemotaxisinflammatoryresponsekillingofcellsofanotherorganismneutrophilchemotaxispositiveregulationofreleaseofsequesteredcalciumionintocytosolregulationofcellpopulationproliferationsignaltransductionTcellchemotaxis
Teneurin-4
2.0
nan
91
TEN4TEN4Q6N022Q6N022cardiaccellfatespecificationcardiacmusclecellproliferationcentralnervoussystemmyelinformationgastrulationwithmouthformingsecondheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesneurondevelopmentpositiveregulationofgastrulationpositiveregulationofmyelinationpositiveregulationofoligodendrocytedifferentiationregulationofmyelinationsignaltransduction
Immunoglobulin J chain
2.0
59
88
IGHMIGJP01871P01591adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationglomerularfiltrationhumoralimmuneresponseimmuneresponsepositiveregulationofrespiratoryburstprotein-containingcomplexassemblyretinahomeostasis
Plexin-B1
2.0
56
88
PLXB1PLXB1O43157O43157cellmigrationinhibitorysynapseassemblyintracellularsignaltransductionnegativeregulationofcelladhesionnegativeregulationofosteoblastproliferationneuronprojectionmorphogenesisossificationinvolvedinbonematurationpositiveregulationofaxonogenesispositiveregulationofGTPaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingregulationofcellmigrationregulationofcellshaperegulationofcytoskeletonorganizationregulationofGTPaseactivitysemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesemaphorin-plexinsignalingpathwayinvolvedinbonetrabeculamorphogenesis
Ighg protein
2.0
nan
90
Q569X1A0A0U5BC76Q569X1A0A0U5BC76
Beta-microseminoprotein
2.0
44
86
MSMBMSMBP08118P08118
V-set and immunoglobulin domain-containing protein 4
2.0
85
79
VSIG4VSIG4Q9Y279Q9Y279complementactivationalternativepathwaynegativeregulationofcomplementactivationalternativepathwaynegativeregulationofinterleukin-2productionnegativeregulationofmacrophageactivationnegativeregulationofTcellproliferation
Mas-related G-protein coupled receptor member X2
2.0
nan
89
MRGX2MRGX2Q96LB1Q96LB1Gprotein-coupledreceptorsignalingpathwaymastcellactivationmastcelldegranulationpositiveregulationofcytokinesissensoryperceptionofpainsleep
Sodium/glucose cotransporter 1
2.0
49
86
SC5A1SC5A1P13866P13866alpha-glucosidetransportfucosetransmembranetransportgalactosetransmembranetransportglucoseimportacrossplasmamembraneglucosetransmembranetransportintestinalD-glucoseabsorptionintestinalhexoseabsorptionmyo-inositoltransportpentosetransmembranetransportrenalglucoseabsorptionresponsetoinorganicsubstancesodiumionimportacrossplasmamembranesodiumiontransporttransepithelialwatertransporttransportacrossblood-brainbarrier
Hepatocyte growth factor-like protein
2.0
57
84
HGFLHGFLP26927P26927negativeregulationofgluconeogenesisproteolysisregulationofcAMP-dependentproteinkinaseactivityregulationofreceptorsignalingpathwayviaJAK-STAT
Angiotensin-converting enzyme
2.0
56
84
A0A6J2EID0A0A6J2EID0A0A6J2EID0A0A6J2EID0proteolysis
Complement C1q subcomponent subunit C
2.0
92
74
C1QCC1QCP02747P02747complementactivationclassicalpathwayimmuneresponseinnateimmuneresponsenegativeregulationofgranulocytedifferentiationnegativeregulationofmacrophagedifferentiationsynapsepruning
Transmembrane protease serine 13
2.0
41
89
TMPSDTMPSDQ9BYE2Q9BYE2proteolysis
Large neutral amino acids transporter small subunit 1
2.0
49
87
LAT14F2Q01650P08195alaninetransportaminoacidimportacrossplasmamembranecellularresponsetoglucosestarvationcellularresponsetoL-argininecellularresponsetolipopolysaccharideisoleucinetransportL-histidinetransportL-leucineimportacrossplasmamembraneL-tryptophantransmembranetransportleucineimportacrossplasmamembraneleucinetransportliverregenerationmethioninetransportnegativeregulationofautophagynegativeregulationofgeneexpressionnegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessneutralaminoacidtransportodontogenesisphenylalaninetransportpositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofglialcellproliferationpositiveregulationofinterleukin-17productionpositiveregulationofinterleukin-4productionpositiveregulationofleucineimportacrossplasmamembranepositiveregulationoftypeIIinterferonproductionprolinetransportresponsetohyperoxiaresponsetomuscleactivitythyroidhormonetransporttransportacrossblood-brainbarriertryptophantransporttyrosinetransportvalinetransportxenobiotictransportaminoacidtransportcalciumiontransportcarbohydratemetabolicprocessL-alanineimportacrossplasmamembraneresponsetoexogenousdsRNAviralentryintohostcell
Acid-sensing ion channel 1
2.1
53
84
ASIC1ASIC1P78348P78348associativelearningbehavioralfearresponsecalciumiontransmembranetransportcellularresponsetopHmemorynegativeregulationofneurotransmittersecretionneurotransmittersecretionproteinhomotrimerizationregulationofmembranepotentialresponsetoacidicpHresponsetoamphetamineresponsetopHsensoryperceptionofsourtastesignaltransductionsodiumiontransmembranetransportsodiumiontransport
Voltage-dependent calcium channel subunit alpha-2/delta-1
2.0
39
88
CA2D1CA2D1P13806P13806calciumionimportacrossplasmamembranecalciumiontransmembranetransportpositiveregulationofmusclecontractionregulationofiontransmembranetransport
Metalloproteinase inhibitor 1
2.0
62
87
TIMP1TIMP1P01033P01033agingcartilagedevelopmentcellactivationcellularresponsetoUV-Aconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingnegativeregulationofapoptoticprocessnegativeregulationofcatalyticactivitynegativeregulationofendopeptidaseactivitynegativeregulationofmembraneproteinectodomainproteolysisnegativeregulationofmetallopeptidaseactivitynegativeregulationoftrophoblastcellmigrationpositiveregulationofcellpopulationproliferationregulationofintegrin-mediatedsignalingpathwayresponsetocytokineresponsetohormoneresponsetoorganicsubstanceresponsetopeptidehormone
Relaxin-3
2.0
nan
91
REL3INSL5Q8WXF3Q9Y5Q6positiveregulationoffeedingbehavior
Mannose-6-phosphate/insulin-like growth factor II receptor
2.0
53
86
Q95LC7Q95LC7Q95LC7Q95LC7lysosomaltransport
Cyclin-G-associated kinase
2.0
67
80
✔
GAKGAKO14976O14976cellcyclechaperonecofactor-dependentproteinrefoldingclathrincoatdisassemblyclathrin-coatedpitassemblyclathrin-dependentendocytosisendoplasmicreticulumorganizationGolgiorganizationGolgitolysosometransportnegativeregulationofneuronprojectiondevelopmentproteinlocalizationtoGolgiapparatusproteinlocalizationtoplasmamembraneproteinphosphorylationreceptor-mediatedendocytosissynapticvesicleuncoating
Interleukin-17A
2.0
39
90
IL17IL17FQ16552Q96PD4adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgeneexpressiongranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenancekeratinocytedifferentiationkeratinocyteproliferationNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductioncartilagedevelopmentnegativeregulationofangiogenesispositiveregulationofcytokineproductionpositiveregulationoflymphotoxinAproductionregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
Gap junction alpha-8 protein
2.0
78
83
CXA8CXA8P55917P55917cellcommunicationgapjunction-mediatedintercellulartransport
Platelet endothelial cell adhesion molecule
2.0
79
83
PECA1PECA1P16284P16284bicellulartightjunctionassemblycellrecognitioncellsurfacereceptorsignalingpathwaycell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculesdiapedesisestablishmentofendothelialbarrierglomerularendotheliumdevelopmenthomophiliccelladhesionviaplasmamembraneadhesionmoleculesleukocytecell-celladhesionmaintenanceofblood-brainbarriermonocyteextravasationneutrophilextravasationphagocytosispositiveregulationofcellmigrationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtocell-celljunctionpositiveregulationofproteinphosphorylationsignaltransduction
N-acetylgalactosamine-6-sulfatase
2.0
58
87
GALNSGALNSP34059P34059
Apoptotic protease-activating factor 1
2.0
86
82
APAFAPAFO14727O14727activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecagingapoptoticprocesscardiacmusclecellapoptoticprocesscelldifferentiationcellularresponsetotransforminggrowthfactorbetastimulusforebraindevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresskidneydevelopmentnervoussystemdevelopmentneuraltubeclosureneuronapoptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwayregulationofapoptoticDNAfragmentationregulationofapoptoticprocessresponsetoG1DNAdamagecheckpointsignalingresponsetohypoxiaresponsetonutrient
Beta-defensin 1
2.0
50
87
DEFB1DEFB1P60022P60022antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingusingintracellularcalciumsourcecAMP-mediatedsignalingchemotaxisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponseinnateimmuneresponseinnateimmuneresponseinmucosapositiveregulationofflagellatedspermmotilityinvolvedincapacitationresponsetobacterium
Receptor tyrosine-protein kinase erbB-4
2.0
53
89
ERBB4ERBB4Q15303Q15303cardiacmuscletissueregenerationcellfatecommitmentcellmigrationcellularresponsetoepidermalgrowthfactorstimuluscentralnervoussystemmorphogenesisembryonicpatternspecificationERBB2-ERBB4signalingpathwayERBB4signalingpathwayERBB4-ERBB4signalingpathwayestablishmentofplanarpolarityinvolvedinnephronmorphogenesisheartdevelopmentlactationmammaryglandalveolusdevelopmentmammaryglandepithelialcelldifferentiationmitochondrialfragmentationinvolvedinapoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentneuralcrestcellmigrationneurogenesisneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneolfactorybulbinterneurondifferentiationpeptidyl-tyrosinephosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofkinaseactivitypositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinlocalizationtocellsurfacepositiveregulationofproteinphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftyrosinephosphorylationofSTATproteinproteinautophosphorylationregulationofcellmigrationsignaltransductionsynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathway
Sodium channel protein type 5 subunit alpha
2.0
64
87
SCN5ASCN5AQ14524Q14524atrialcardiacmusclecellactionpotentialAVnodecellactionpotentialAVnodecelltobundleofHiscellcommunicationbrainstemdevelopmentbundleofHiscellactionpotentialcardiacconductionsystemdevelopmentcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractioncardiacventricledevelopmentcellularresponsetocalciumioncerebellumdevelopmentmembranedepolarizationmembranedepolarizationduringactionpotentialmembranedepolarizationduringatrialcardiacmusclecellactionpotentialmembranedepolarizationduringAVnodecellactionpotentialmembranedepolarizationduringbundleofHiscellactionpotentialmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringPurkinjemyocytecellactionpotentialmembranedepolarizationduringSAnodecellactionpotentialneuronalactionpotentialodontogenesisofdentin-containingtoothpositiveregulationofactionpotentialpositiveregulationofepithelialcellproliferationpositiveregulationofsodiumiontransportregulationofatrialcardiacmusclecellmembranedepolarizationregulationofatrialcardiacmusclecellmembranerepolarizationregulationofcardiacmusclecellcontractionregulationofheartrateregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransportregulationofventricularcardiacmusclecellmembranedepolarizationregulationofventricularcardiacmusclecellmembranerepolarizationresponsetodenervationinvolvedinregulationofmuscleadaptationSAnodecellactionpotentialsodiumiontransmembranetransportsodiumiontransporttelencephalondevelopmentventricularcardiacmusclecellactionpotential
MAM domain-containing glycosylphosphatidylinositol anchor protein 1
2.0
72
84
MDGA1MDGA1Q8NFP4Q8NFP4braindevelopmentcerebralcortexradiallyorientedcellmigrationnervoussystemdevelopmentneuronmigrationregulationofpresynapseassemblyregulationofsynapticmembraneadhesionspinalcordassociationneurondifferentiation
Receptor-type tyrosine-protein phosphatase zeta
2.0
62
86
PTPRZPTPRZP23471P23471axonogenesiscentralnervoussystemdevelopmenthematopoieticprogenitorcelldifferentiationlearningormemorynegativeregulationofneuronapoptoticprocessoligodendrocytedifferentiationpeptidyl-tyrosinedephosphorylationpositiveregulationofoligodendrocytedifferentiationproteindephosphorylationregulationofmyelinationregulationofoligodendrocyteprogenitorproliferation
HLA class II histocompatibility antigen DQ alpha chain
2.0
82
80
Q5Y7C3Q5Y7C3Q5Y7C3Q5Y7C3adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Interleukin-6 receptor subunit alpha
2.0
nan
87
IL6RAIL6RAP08887P08887acute-phaseresponseciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendocrinepancreasdevelopmentextrinsicapoptoticsignalingpathwayhepaticimmuneresponseinterleukin-6-mediatedsignalingpathwaymonocytechemotaxisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofinterleukin-8productionneutrophilmediatedimmunitypositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofinterleukin-6productionpositiveregulationofleukocytechemotaxispositiveregulationofMAPKcascadepositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofplateletaggregationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinresponsetocytokineT-helper17celllineagecommitmentvascularendothelialgrowthfactorproduction
Fibroblast growth factor 21
2.0
84
77
FGF21FGF21Q9NSA1Q9NSA1animalorganmorphogenesiscelldifferentiationcell-cellsignalingcellularresponsetoglucagonstimuluscellularresponsetoglucosestimuluscellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetoxenobioticstimulusendoplasmicreticulumunfoldedproteinresponseendothelialcellapoptoticprocessfibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofneurondeathpositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationoflow-densitylipoproteinreceptoractivitypositiveregulationofMAPKKKcascadebyfibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofproteinphosphorylationpositiveregulationoftriglyceridecatabolicprocessregulationofcellmigrationregulationoflow-densitylipoproteinparticleclearanceresponsetoactivityresponsetomethionineresponsetonutrientlevelssignaltransduction
Neuroglobin
2.0
45
89
NGBNGBQ9NPG2Q9NPG2apoptoticprocessoxygentransportresponsetohypoxia
H2-T23 protein
2.1
83
82
Q31153Q31153Q31153Q31153
Tumor necrosis factor receptor superfamily member 14
2.0
65
90
TNR14TNR14Q92956Q92956adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumimmuneresponseinnateimmuneresponsenegativeregulationofadaptiveimmunememoryresponsenegativeregulationofalpha-betaTcellproliferationpositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellmigrationTcellcostimulation
Xenotropic and polytropic retrovirus receptor 1
2.0
64
84
✔
XPR1XPR1Q9UBH6Q9UBH6cellularphosphateionhomeostasiscellularresponsetophosphatestarvationGprotein-coupledreceptorsignalingpathwayphosphateiontransmembranetransportphosphateiontransportresponsetovirus
Ectonucleotide pyrophosphatase/phosphodiesterase 2
2.1
40
87
K7CID1K7CID1K7CID1K7CID1immuneresponsenitrogencompoundmetabolicprocessorganicsubstancemetabolicprocessprimarymetabolicprocess
Granulocyte-macrophage colony-stimulating factor
2.0
52
87
CSF2CSF2P04141P04141cellpopulationproliferationcellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetolipopolysaccharidedendriticcelldifferentiationembryonicplacentadevelopmentepithelialfluidtransportgranulocyte-macrophagecolony-stimulatingfactorsignalingpathwayhistaminesecretionimmuneresponsemacrophageactivationmacrophagedifferentiationmonocytedifferentiationmyeloidcelldifferentiationmyeloiddendriticcelldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandneutrophildifferentiationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-23productionpositiveregulationofleukocyteproliferationpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofpodosomeassemblypositiveregulationoftyrosinephosphorylationofSTATproteinproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofcircadiansleep/wakecyclesleepresponsetofluidshearstressresponsetosilicondioxide
cDNA FLJ54183, highly similar to HLA class I histocompatibility antigen, Cw-7 alpha chain
2.0
80
81
B4DVY0B4DVY0B4DVY0B4DVY0antigenprocessingandpresentationimmuneresponse
Acid ceramidase
2.0
63
85
ASAH1ASAH1A0A383ZFX3A0A383ZFX3fattyacidmetabolicprocesssphingolipidmetabolicprocess
Kin of IRRE-like protein 3
2.0
89
79
KIRR3KIRR3Q8BR86Q8BR86cell-celladhesionglomerulusmorphogenesishemopoiesishippocampusdevelopmenthomophiliccelladhesionviaplasmamembraneadhesionmoleculesinter-maleaggressivebehaviorneuronmigrationneuronprojectionmorphogenesisprincipalsensorynucleusoftrigeminalnervedevelopmentsynapseassembly
Lutropin-choriogonadotropic hormone receptor
2.0
66
84
LSHRLSHRP22888P22888activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayarachidonicacidsecretioncellularresponsetogonadotropinstimuluscellularresponsetoluteinizinghormonestimuluscentralnervoussystemdevelopmentcognitiondevelopmentofsecondarymalesexualcharacteristicsGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhormone-mediatedsignalingpathwayluteinizinghormonesignalingpathwaymalegenitaliadevelopmentmalegonaddevelopmentovarianfollicledevelopmentovulationcycleprocessphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcalciumiontransportintocytosolpositiveregulationofcalcium-mediatedsignalingpositiveregulationofhormonebiosyntheticprocesspositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofreleaseofsequesteredcalciumionintocytosolproteintargetingtolysosomeregulationofsteroidhormonebiosyntheticprocessresponsetoxenobioticstimulusseminiferoustubuledevelopmentspermatogenesisuterusdevelopment
Intercellular adhesion molecule 3
2.0
50
88
ICAM3ICAM3P32942P32942celladhesioncell-celladhesionphagocytosis
Plexin-A4
2.0
45
89
PLXA4PLXA4Q80UG2Q80UG2anteriorcommissuremorphogenesisaxonguidancebranchiomotorneuronaxonguidancechemorepulsionofbranchiomotoraxoncranialnervemorphogenesisembryonichearttubedevelopmentfacialnervemorphogenesisfacialnervestructuralorganizationglossopharyngealnervemorphogenesismaintenanceofsynapsestructuremotorneuronaxonguidancenegativeregulationofcelladhesionnervoussystemdevelopmentneuronprojectionmorphogenesispositiveregulationofaxonogenesispostganglionicparasympatheticfiberdevelopmentregulationofaxonextensioninvolvedinaxonguidanceregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivityregulationofnegativechemotaxissemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesympatheticnervoussystemdevelopmentsympatheticneuronaxonguidancetrigeminalnervemorphogenesistrigeminalnervestructuralorganizationvagusnervemorphogenesis
Protein dispatched homolog 1
2.0
nan
91
DISP1DISP1Q3TDN0Q3TDN0determinationofleft/rightsymmetrydiaphragmdevelopmentdorsal/ventralpatternformationembryonicpatternspecificationpatchedligandmaturationpeptidetransportsmoothenedsignalingpathwaytransmembranetransport
CD59 glycoprotein
2.0
52
87
CD59CD59P13987P13987bloodcoagulationcellsurfacereceptorsignalingpathwaynegativeregulationofactivationofmembraneattackcomplexregulationofcomplementactivationregulationofcomplement-dependentcytotoxicity
Voltage-dependent T-type calcium channel subunit alpha-1G
2.0
47
89
CAC1GCAC1GO43497O43497AVnodecellactionpotentialAVnodecelltobundleofHiscellsignalingcalciumionimportcalciumiontransmembranetransportcardiacmusclecellactionpotentialinvolvedincontractionchemicalsynaptictransmissionmembranedepolarizationduringactionpotentialmembranedepolarizationduringAVnodecellactionpotentialmembranedepolarizationduringSAnodecellactionpotentialneuronalactionpotentialpositiveregulationofcalciumion-dependentexocytosisregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportregulationofmembranepotentialresponsetonickelcationSAnodecellactionpotentialSAnodecelltoatrialcardiacmusclecellsignalingsinoatrialnodedevelopment
Inositol polyphosphate 5-phosphatase OCRL
2.0
70
85
OCRLOCRLQ01968Q01968ciliumassemblyinuteroembryonicdevelopmentinositolphosphatedephosphorylationinositolphosphatemetabolicprocesslipidmetabolicprocessmembraneorganizationphosphatidylinositolbiosyntheticprocessphosphatidylinositoldephosphorylationregulationofGTPaseactivitysignaltransduction
Ribonuclease K6
2.0
57
87
RNAS6RNAS6Q93091Q93091antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseRNAcatabolicprocessRNAphosphodiesterbondhydrolysis
Claudin-9
2.0
77
81
CLD9CLD9O95484O95484bicellulartightjunctionassemblycalcium-independentcell-celladhesionviaplasmamembranecell-adhesionmoleculescelladhesion
Leukemia inhibitory factor
2.0
53
86
LIFLIFP09056P09056animalorganregenerationastrocytedifferentiationbloodvesselremodelingcellpopulationproliferationdecidualizationembryoimplantationfibroblastproliferationimmuneresponseleukemiainhibitoryfactorsignalingpathwaylungalveolusdevelopmentlungdevelopmentlunglobemorphogenesislungvasculaturedevelopmentmaternalprocessinvolvedinfemalepregnancymeioticnucleardivisionmuscleorganmorphogenesisnegativeregulationofangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofERK1andERK2cascadenegativeregulationofhormonesecretionnegativeregulationofmeioticnucleardivisionneurondevelopmentpositiveregulationofastrocytedifferentiationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellpopulationproliferationpositiveregulationofcorticotropinsecretionpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofhistoneH3-K27acetylationpositiveregulationofmacrophagedifferentiationpositiveregulationofMAPKcascadepositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-serinephosphorylationofSTATproteinpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtonucleuspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcelldifferentiationregulationofmetanephricnephrontubuleepithelialcelldifferentiationregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbindingretinadevelopmentincamera-typeeyesomaticstemcellpopulationmaintenancespongiotrophoblastdifferentiationstemcelldifferentiationtransdifferentiationtrophoblastgiantcelldifferentiationtyrosinephosphorylationofSTATprotein
Glycoprotein hormones alpha chain
2.0
66
85
Q96QJ4Q96QJ4Q96QJ4Q96QJ4
Thyrotropin receptor
2.0
50
86
A0A0A0MTJ0A0A0A0MTJ0A0A0A0MTJ0A0A0A0MTJ0adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehaviorBcelldifferentiationcochleamorphogenesisdopaminergicneurondifferentiationinnerearreceptorcellstereociliumorganizationpositiveregulationofcold-inducedthermogenesispositiveregulationofmulticellularorganismgrowthregulationoflocomotion
Inositol monophosphatase 2
2.0
74
84
✔
IMPA2IMPA2O14732O14732inositolbiosyntheticprocessinositolmetabolicprocessinositolphosphatedephosphorylationphosphate-containingcompoundmetabolicprocessphosphatidylinositolphosphatebiosyntheticprocessresponsetolithiumionsignaltransduction
C-type lectin domain family 4 member E
2.0
53
86
CLC4ECLC4EQ9ULY5Q9ULY5antifungalinnateimmuneresponsedefenseresponsetobacteriumFc-gammareceptorsignalingpathwayimmuneresponseinnateimmuneresponsepatternrecognitionreceptorsignalingpathwaypositiveregulationofcytokineproductionTcelldifferentiationinvolvedinimmuneresponse
Urokinase plasminogen activator
2.0
71
83
Q5PY49Q5PY49Q5PY49Q5PY49phosphorylationproteolysis
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2
2.0
41
88
WFKN2WFKN2Q7TQN3Q7TQN3musclecelldevelopmentnegativeregulationofDNAbindingnegativeregulationofpeptidaseactivitynegativeregulationofproteinbindingnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayroofofmouthdevelopmentskeletalsystemdevelopmenttransforminggrowthfactorbetareceptorsignalingpathway
Maltase-glucoamylase
2.0
63
86
MGAMGAO43451O43451dextrincatabolicprocessmaltosecatabolicprocessstarchcatabolicprocess
G-protein coupled receptor 52
2.0
65
86
GPR52GPR52Q9Y2T5Q9Y2T5cellularresponsetolightstimulusGprotein-coupledreceptorsignalingpathwaylocomotorybehaviorphototransductionresponsetoxenobioticstimulus
Protein tyrosine phosphatase type IVA 2
2.0
67
81
TP4A2TP4A2O70274O70274proteindephosphorylation
V2-17 protein
2.0
90
80
Q5NV90Q5NV90Q5NV90Q5NV90
Killer cell immunoglobulin-like receptor 2DS2
2.0
88
81
KI2S2KI2S2P43631P43631immuneresponsestimulatorykillercellimmunoglobulin-likereceptorsignalingpathway
Beta-2-microglobulin
2.0
81
80
L5K3Y9L5K3Y9L5K3Y9L5K3Y9antigenprocessingandpresentationofpeptideantigenviaMHCclassIimmuneresponse
Bone marrow proteoglycan
2.0
55
86
PRG2PAPP1P13727Q13219defenseresponsetobacteriumdefenseresponsetonematodeimmuneresponsenegativeregulationofinterleukin-10productionnegativeregulationofmacrophagecytokineproductionpositiveregulationofinterleukin-4productioncellsurfacereceptorsignalingpathwayfemalepregnancyproteincatabolicprocessproteinmetabolicprocessproteolysisresponsetodexamethasoneresponsetofollicle-stimulatinghormone
Vascular endothelial growth factor A
2.0
46
88
VEGFAVEGFAP15692P15692activationofproteinkinaseactivityangiogenesisarterymorphogenesisbasophilchemotaxisbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyemorphogenesiscardiacmusclecelldevelopmentcardiacvascularsmoothmusclecelldevelopmentcellmaturationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetohypoxiacellularresponsetovascularendothelialgrowthfactorstimuluscellularstressresponsetoacidchemicalcommissuralneuronaxonguidancecoronaryarterymorphogenesiscoronaryveinmorphogenesisdopaminergicneurondifferentiationendothelialcellchemotaxisepithelialcelldifferentiationeyephotoreceptorcelldevelopmentheartmorphogenesisinuteroembryonicdevelopmentinductionofpositivechemotaxiskidneydevelopmentlactationlungdevelopmentlymphvesselmorphogenesismacrophagedifferentiationmammaryglandalveolusdevelopmentmesodermdevelopmentmonocytedifferentiationmotorneuronmigrationnegativeregulationofadherensjunctionorganizationnegativeregulationofapoptoticprocessnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofestablishmentofendothelialbarriernegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentoutflowtractmorphogenesisovarianfollicledevelopmentpositivechemotaxispositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelladhesionpositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylaseactivitypositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmastcellchemotaxispositiveregulationofneuroblastproliferationpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofpositivechemotaxispositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinkinaseDsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftrophoblastcellmigrationpositiveregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofvascularpermeabilitypost-embryoniccamera-typeeyedevelopmentprimitiveerythrocytedifferentiationregulationofcellshaperegulationofnitricoxidemediatedsignaltransductionregulationofretinalganglioncellaxonguidanceregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiasproutingangiogenesissurfactanthomeostasistubeformationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-2signalingpathwayvascularendothelialgrowthfactorsignalingpathwayvascularwoundhealingvasculogenesisVEGF-activatedneuropilinsignalingpathway
Integrin alpha-IIb
2.0
42
89
ITA2BITB3P08514P05106angiogenesiscelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionintegrin-mediatedsignalingpathwayactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancebloodcoagulationcelladhesioncellmigrationcell-substrateadhesioncell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationheterotypiccell-celladhesionmaintenanceofpostsynapticspecializationstructuremesodermalcelldifferentiationnegativechemotaxisnegativeregulationofcelldeathnegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptordiffusiontrappingregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationsubstrateadhesion-dependentcellspreadingtubedevelopmentviralentryintohostcellwoundhealing
HLA class I histocompatibility antigen, C alpha chain
2.0
80
81
✔
HLACHLACP10321P10321adaptiveimmuneresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-independentimmuneresponseinnateimmuneresponse
Carboxypeptidase M
2.0
49
87
CBPMCBPMP14384P14384anatomicalstructuremorphogenesispeptidemetabolicprocessproteinprocessing
Receptor-type tyrosine-protein phosphatase mu
2.0
nan
87
PTPRMPTPRMP28827P28827homophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofangiogenesisnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationneuronprojectiondevelopmentproteindephosphorylationresponsetoxenobioticstimulusretinalayerformationretinalganglioncellaxonguidancesignaltransduction
Adenosine deaminase 2
2.0
56
86
ADA2ADA2Q9NZK5Q9NZK5adenosinecatabolicprocessinosinebiosyntheticprocess
Gamma-aminobutyric acid receptor subunit beta-2
2.0
67
81
GBRB2GBRB2P47870P47870cellularresponsetohistaminechemicalsynaptictransmissionchloridetransmembranetransportcochleadevelopmentgamma-aminobutyricacidsignalingpathwayinhibitorysynapseassemblyinnerearreceptorcelldevelopmentinnervationiontransmembranetransportnegativeregulationofneuronapoptoticprocessnervoussystemprocessregulationofmembranepotentialsensoryperceptionofsoundsignaltransductionsynaptictransmissionGABAergic
Basal cell adhesion molecule
2.0
76
83
BCAMBCAMP50895P50895celladhesioncell-matrixadhesionsignaltransduction
Receptor-type tyrosine-protein phosphatase S
2.0
79
83
PTPRSPTPRSQ13332Q13332cerebellumdevelopmentcerebralcortexdevelopmentcorpuscallosumdevelopmentestablishmentofendothelialintestinalbarrierhippocampusdevelopmentmodulationofchemicalsynaptictransmissionnegativeregulationofaxonextensionnegativeregulationofaxonregenerationnegativeregulationofcollateralsproutingnegativeregulationofdendriticspinedevelopmentnegativeregulationofinterferon-alphaproductionnegativeregulationofinterferon-betaproductionnegativeregulationofneuronprojectiondevelopmentnegativeregulationoftoll-likereceptor9signalingpathwaypeptidyl-tyrosinedephosphorylationproteindephosphorylationregulationofpostsynapticdensityassemblyspinalcorddevelopmentsynapticmembraneadhesiontrans-synapticsignaling
Kunitz-type protease inhibitor 1
2.0
nan
90
SPIT1SPIT1O43278O43278branchinginvolvedinlabyrinthinelayermorphogenesiscellularresponsetoBMPstimulusepidermisdevelopmentepitheliumdevelopmentextracellularmatrixorganizationnegativeregulationofneuralprecursorcellproliferationnegativeregulationofpeptidaseactivityneuraltubeclosureplacentabloodvesseldevelopmentpositiveregulationofglialcelldifferentiation
Matrix remodeling-associated protein 8
2.0
55
85
MXRA8MXRA8Q9BRK3Q9BRK3celladhesioncelldifferentiationestablishmentofglialblood-brainbarrier
T-cell surface glycoprotein CD8 alpha chain
2.0
87
80
A0MNZ3A0MNZ3A0MNZ3A0MNZ3
Peptidyl-prolyl cis-trans isomerase-like 3
2.0
61
83
PPIL3PPIL3Q9H2H8Q9H2H8mRNAsplicingviaspliceosomeproteinfoldingproteinpeptidyl-prolylisomerization
T-cell surface glycoprotein CD3 delta chain
2.0
62
85
CD3DCD3DP04234P04234adaptiveimmuneresponsealpha-betaTcellactivationcellsurfacereceptorsignalingpathwaypositivethymicTcellselectionTcellreceptorsignalingpathway
ATP-binding cassette sub-family G member 1
2.0
44
89
ABCG1ABCG1P45844P45844amyloidprecursorproteincatabolicprocesscellularresponsetohighdensitylipoproteinparticlestimuluscholesteroleffluxcholesterolhomeostasischolesterolmetabolicprocessglycoproteintransporthigh-densitylipoproteinparticleremodelingintracellularcholesteroltransportlow-densitylipoproteinparticleremodelingnegativeregulationofcholesterolstoragenegativeregulationofmacrophagederivedfoamcelldifferentiationphospholipideffluxphospholipidhomeostasispositiveregulationofamyloid-betaformationpositiveregulationofcholesterolbiosyntheticprocesspositiveregulationofcholesteroleffluxpositiveregulationofproteinsecretionregulationofcholesterolmetabolicprocessresponsetolipidresponsetoorganicsubstancereversecholesteroltransporttransmembranetransport
Sodium channel protein type 9 subunit alpha
2.0
45
86
SCN9ASCN9AQ15858Q15858behavioralresponsetoformalininducedpaincircadianrhythmdetectionofmechanicalstimulusinvolvedinsensoryperceptiondetectionoftemperaturestimulusinvolvedinsensoryperceptionofpaininflammatoryresponsemembranedepolarizationduringactionpotentialnegativeregulationofactionpotentialneuronalactionpotentialpost-embryonicdevelopmentregulationofiontransmembranetransportresponsetocoldresponsetoheatresponsetotoxicsubstancesensoryperceptionofpainsodiumiontransmembranetransportsodiumiontransport
Butyrophilin subfamily 3 member A2
2.0
77
81
BT3A2BT3A2P78410P78410positiveregulationoftypeIIinterferonproductionregulationofcytokineproductionTcellmediatedimmunityTcellreceptorsignalingpathway
Dipeptidylpeptidase 6
2.0
55
85
E9PWX1E9PWX1E9PWX1E9PWX1proteolysisregulationofpotassiumiontransmembranetransport
Disintegrin and metalloproteinase domain-containing protein 8
2.0
67
84
✔
ADAM8ADAM8P78325P78325angiogenesiscellmorphogenesiscell-celladhesioncellularresponsetohypoxiaextracellularmatrixdisassemblyinflammatoryresponseleukocytemigrationinvolvedininflammatoryresponselymphocytechemotaxisnegativeregulationofneuronapoptoticprocesspositiveregulationofacuteinflammatoryresponsepositiveregulationofboneresorptionpositiveregulationofcelladhesionpositiveregulationofcellularextravasationpositiveregulationofeosinophilmigrationpositiveregulationoffibronectin-dependentthymocytemigrationpositiveregulationofinnateimmuneresponsepositiveregulationofMAPkinaseactivitypositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofneutrophilextravasationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinprocessingpositiveregulationofproteinsecretionpositiveregulationofTcelldifferentiationinthymuspositiveregulationofthymocyteapoptoticprocesspositiveregulationoftumornecrosisfactor(ligand)superfamilymember11productionproteolysisregulationofcell-celladhesion
CUB and sushi domain-containing protein 1
2.1
50
88
CSMD1CSMD1Q96PZ7Q96PZ7conditionedplacepreferencefemalegonaddevelopmentglucosehomeostasismalegonaddevelopmentmammaryglandbranchinginvolvedinpregnancymemoryoviductepitheliumdevelopmentstartleresponse
Gamma-aminobutyric acid type B receptor subunit 1
2.0
51
88
GABR1GABR1Q9Z0U4Q9Z0U4adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticGprotein-coupledreceptorsignalingpathwaygamma-aminobutyricacidsignalingpathwaynegativeregulationofadenylatecyclaseactivitynegativeregulationofcellpopulationproliferationnegativeregulationofdopaminesecretionnegativeregulationofepinephrinesecretionnegativeregulationofgamma-aminobutyricacidsecretionnegativeregulationofsynaptictransmissionneuron-glialcellsignalingosteoblastdifferentiationpositiveregulationofglutamatesecretionpositiveregulationofgrowthhormonesecretionregulationofglutamatesecretionregulationofpostsynapticmembranepotentialresponsetoethanolresponsetonicotinesynaptictransmissionGABAergic
Low-density lipoprotein receptor-related protein 2
2.0
nan
90
LRP2LRP2A2ARV4A2ARV4amyloid-betaclearanceaortadevelopmentcellpopulationproliferationcellularresponsetogrowthfactorstimuluschemoattractionofaxoncoronaryarterymorphogenesiscoronaryvasculaturedevelopmentdiolmetabolicprocessendocytichemoglobinimportintocellendocytosisendosomaltransportfolateimportacrossplasmamembraneforebraindevelopmentheartdevelopmenthormonesecretionkidneydevelopmentmalegonaddevelopmentmetaliontransportnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwayneuraltubeclosureneuronprojectionarborizationoutflowtractseptummorphogenesispositiveregulationofendocytosispositiveregulationoflipoproteintransportpositiveregulationofneurogenesispositiveregulationofoligodendrocyteprogenitorproliferationpositiveregulationofproteinkinaseBsignalingproteinimportproteintransportpulmonaryarterymorphogenesisreceptor-mediatedendocytosisresponsetoleptinresponsetoX-raysecondaryheartfieldspecificationsensoryperceptionofsoundtranscytosisvaginadevelopmentventricularcompactmyocardiummorphogenesisventricularseptumdevelopmentvitaminDmetabolicprocess
Mesencephalic astrocyte-derived neurotrophic factor
2.0
40
89
MANFMANFP55145P55145dopaminergicneurondifferentiationneuronprojectiondevelopmentregulationofresponsetoendoplasmicreticulumstressresponsetounfoldedprotein
Cathepsin K
2.0
67
85
CATKCATKP61277P61277immuneresponseproteolysisinvolvedinproteincatabolicprocessthyroidhormonegeneration
Interleukin-1 receptor accessory protein-like 1
2.0
52
88
TUSC3IRPL1Q13454Q9NZN1cognitionmagnesiumiontransportproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparaginetransmembranetransportheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesnegativeregulationofexocytosisneurondifferentiationpositiveregulationofdendritemorphogenesispositiveregulationofsynapseassemblypresynapticmembraneassemblyregulationofneuronprojectiondevelopmentregulationofpostsynapseorganizationregulationofpresynapseassemblysignaltransductiontrans-synapticsignalingbytrans-synapticcomplex
Uromodulin
2.0
50
88
UROMUROMP07911P07911antibacterialinnateimmuneresponseapoptoticsignalingpathwayautophagycellularcalciumionhomeostasiscellularchlorideionhomeostasiscellulardefenseresponsecellularphosphateionhomeostasiscellularresponsetounfoldedproteincellularsodiumionhomeostasischaperone-mediatedproteinfoldingcitricacidsecretioncollectingductdevelopmentconnectivetissuereplacementcreatininehomeostasisdefenseresponsetoGram-negativebacteriumendoplasmicreticulumorganizationglomerularfiltrationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinflammatoryresponsejuxtaglomerularapparatusdevelopmentleukocytecell-celladhesionlipidmetabolicprocessmetanephricascendingthinlimbdevelopmentmetanephricdistalconvolutedtubuledevelopmentmetanephricthickascendinglimbdevelopmentmicturitionmulticellularorganismalresponsetostressnegativeregulationofcellpopulationproliferationneutrophilmigrationorganortissuespecificimmuneresponsepeptidyl-threoninephosphorylationpotassiumionhomeostasisproteinlocalizationtovacuoleproteintransportintoplasmamembraneraftregulationofbloodpressureregulationofproteintransportregulationofurinevolumerenalsodiumionabsorptionrenaluratesaltexcretionrenalwaterhomeostasisresponsetolipopolysaccharideresponsetowaterdeprivationresponsetoxenobioticstimulusRNAsplicingtumornecrosisfactor-mediatedsignalingpathwayubiquitin-dependentERADpathwayuratetransportureatransmembranetransport
HLA class II histocompatibility antigen, DRB1 beta chain
2.0
79
79
DRB1DRB1P01911P01911antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIdetectionofbacteriumepidermisdevelopmenthumoralimmuneresponseimmuneresponseinflammatoryresponsetoantigenicstimulusmacrophagedifferentiationmyeloiddendriticcellantigenprocessingandpresentationnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofTcellproliferationnegativeregulationoftypeIIinterferonproductionpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofCD4-positivealpha-betaTcellactivationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmemoryTcelldifferentiationpositiveregulationofmonocytedifferentiationpositiveregulationofproteinphosphorylationpositiveregulationofTcellactivationpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellmediatedimmuneresponsetotumorcellpositiveregulationofviralentryintohostcellproteintetramerizationregulationofinterleukin-10productionregulationofinterleukin-4productionregulationofT-helpercelldifferentiationsignaltransductionTcellreceptorsignalingpathwayT-helper1typeimmuneresponse
Activin receptor type-2A
2.0
66
84
AVR2AAVR2AP27038P27038activinreceptorsignalingpathwayanterior/posteriorpatternspecificationBMPsignalingpathwaycellularresponsetoBMPstimuluscellularresponsetogrowthfactorstimulusdeterminationofleft/rightsymmetryembryonicskeletalsystemdevelopmentgastrulationwithmouthformingsecondmalegonaddevelopmentmesodermdevelopmentodontogenesisofdentin-containingtoothpenileerectionpositiveregulationofactivinreceptorsignalingpathwaypositiveregulationofbonemineralizationpositiveregulationoferythrocytedifferentiationpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofnitric-oxidesynthaseactivityregulationofsignaltransductionSertolicellproliferationspermejaculationspermatogenesis
Tyrosine-protein kinase transmembrane receptor ROR2
2.0
nan
87
ROR2ROR2Q01974Q01974astrocytedevelopmentbonemineralizationmacrophagemigrationmalegenitaliadevelopmentpositiveregulationofcellmigrationpositiveregulationofJUNkinaseactivitypositiveregulationofkinaseactivitypositiveregulationofmacrophagedifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseCactivitypositiveregulationofsynaptictransmissionglutamatergicregulationofpostsynapseorganizationregulationofsynapticsignalingbynitricoxidesignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Voltage-dependent R-type calcium channel subunit alpha-1E
2.0
62
87
CAC1ECAC1EQ15878Q15878calciumionimportacrossplasmamembranechemicalsynaptictransmissionregulationofiontransmembranetransport
Odorant binding protein I f
2.0
54
88
Q9QYU9Q9QYU9Q9QYU9Q9QYU9
Mu-type opioid receptor
2.0
65
84
OPRMOPRMP35372P35372acuteinflammatoryresponsetoantigenicstimulusadenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwayadenylatecyclase-inhibitingopioidreceptorsignalingpathwaybehavioralresponsetoethanoleatingbehaviorestrouscycleexcitatorypostsynapticpotentialGprotein-coupledopioidreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernegativeregulationofadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaynegativeregulationofcAMP-mediatedsignalingnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofWntproteinsecretionneuropeptidesignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofappetitepositiveregulationofcAMP-mediatedsignalingpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofneurogenesispositiveregulationofnitricoxidebiosyntheticprocessregulationofcellularresponsetostressregulationofNMDAreceptoractivityregulationofsensoryperceptionofpainresponsetococaineresponsetofoodresponsetogrowthfactorresponsetolipopolysaccharideresponsetoradiationsensoryperceptionsensoryperceptionofpainwoundhealing
IGL c4029_light_IGKV1-39_IGKJ2
2.0
85
79
A0A5C2G4I7A0A5C2G4I7A0A5C2G4I7A0A5C2G4I7
Complement factor B
2.0
56
87
CFABCFABP00751P00751complementactivationcomplementactivationalternativepathwaypositiveregulationofimmuneresponsepositiveregulationofopsonizationproteolysisresponsetobacterium
Protein-serine O-palmitoleoyltransferase porcupine
3.2
51
89
PORCNPORCNQ9H237Q9H237glycoproteinmetabolicprocesslipidmodificationproteinlipidationproteinpalmitoleylationproteinpalmitoylationregulationofpostsynapticmembraneneurotransmitterreceptorlevelsWntproteinsecretionWntsignalingpathway
Hedgehog-interacting protein
2.0
57
89
HHIPHHIPQ96QV1Q96QV1dorsal/ventralpatternformationepithelialtubebranchinginvolvedinlungmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofsignaltransductionnegativeregulationofsmoothenedsignalingpathwayneuroblastproliferationregulationoffibroblastgrowthfactorreceptorsignalingpathwaysignaltransductionskeletalsystemmorphogenesis
Butyrophilin subfamily 3 member A3
2.0
80
81
BT3A3BT3A3O00478O00478regulationofcytokineproductionTcellmediatedimmunityTcellreceptorsignalingpathway
Glioma pathogenesis-related protein 1
2.0
48
89
GLIP1GLIP1P48060P48060
Complement C1r subcomponent
2.0
56
87
C1RC1RP00736P00736complementactivationclassicalpathwayimmuneresponseinnateimmuneresponsezymogenactivation
Protein FAM3A
2.0
55
87
FAM3AFAM3AQ9D8T0Q9D8T0antifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidenegativeregulationofantifungalinnateimmuneresponse
Kallikrein-8
2.0
67
85
KLK8KLK8O60259O60259celldeathkeratinocyteproliferationmemorynegativeregulationofaxonregenerationnegativeregulationofmyelinationneuronprojectionmorphogenesisproteolysisregulationofsynapseorganizationresponsetowounding
Protein tweety homolog 2
2.0
66
83
TTYH2TTYH2Q9BSA4Q9BSA4
Uncharacterized protein DKFZp686L19235
2.0
51
85
Q6MZV6Q6MZV6Q6MZV6Q6MZV6
Neuroligin-2
2.0
72
84
NLGN2NLGN2Q8NFZ4Q8NFZ4braindevelopmentcell-celladhesioncell-celljunctionmaintenancechemicalsynaptictransmissiongephyrinclusteringinvolvedinpostsynapticdensityassemblyinhibitorysynapseassemblyinsulinmetabolicprocessjumpresponselocomotoryexplorationbehaviormodulationofchemicalsynaptictransmissionneuromuscularprocesscontrollingbalanceneuroncell-celladhesionneurotransmitter-gatedionchannelclusteringpositiveregulationofcellpopulationproliferationpositiveregulationofdendriticspinedevelopmentpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofinhibitorypostsynapticpotentialpositiveregulationofinsulinsecretionpositiveregulationofproteinlocalizationtosynapsepositiveregulationofsynapseassemblypositiveregulationofsynaptictransmissionGABAergicpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofsynapticvesicleclusteringpositiveregulationoft-SNAREclusteringpostsynapticdensityprotein95clusteringpostsynapticmembraneassemblypresynapseassemblypresynapticmembraneassemblyproteinlocalizationtocellsurfaceproteinlocalizationtosynapseregulationofAMPAreceptoractivityregulationofpresynapseassemblyregulationofrespiratorygaseousexchangebynervoussystemprocesssensoryperceptionofpainsocialbehaviorsynapseassemblysynapseorganizationsynaptictransmissionGABAergicsynapticvesicleendocytosisterminalbuttonorganizationthigmotaxis
Ig-like domain-containing protein
2.0
89
81
Q7TND8Q7TND8Q7TND8Q7TND8
Growth hormone receptor
2.0
65
84
GHRGHRP10912P10912activationofJanuskinaseactivitycartilagedevelopmentinvolvedinendochondralbonemorphogenesiscellularresponsetohormonestimuluscellularresponsetoinsulinstimuluscytokine-mediatedsignalingpathwayendocytosisgrowthhormonereceptorsignalingpathwayhormonemetabolicprocesshormone-mediatedsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaylocalizationnegativeregulationofneurondeathpositiveregulationofcelldifferentiationpositiveregulationofMAPkinaseactivitypositiveregulationofmulticellularorganismgrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftyrosinephosphorylationofSTATproteinreceptorinternalizationreceptorsignalingpathwayviaJAK-STATregulationofmulticellularorganismgrowthresponsetocycloheximideresponsetoestradiolresponsetofoodresponsetoglucocorticoidresponsetogravityresponsetointerleukin-1responsetomorphinetaurinemetabolicprocess
Calcium homeostasis modulator protein 2
2.0
81
80
CAHM2CAHM2Q9HA72Q9HA72positiveregulationofapoptoticprocess
Growth hormone-releasing hormone receptor
2.1
65
85
GHRHRGHRHRQ02643Q02643activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycAMP-mediatedsignalingcellmaturationcellsurfacereceptorsignalingpathwaycellularresponsetoglucosestimuluscellularresponsetoinsulinstimulusdeterminationofadultlifespanestablishmentoflocalizationincellgrowthhormonesecretionhormonemetabolicprocesslactationmulticellularorganismalreproductiveprocesspositiveregulationofcellpopulationproliferationpositiveregulationofcircadiansleep/wakecyclenon-REMsleeppositiveregulationofgrowthhormonesecretionpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofmulticellularorganismgrowthregulationofintracellularsteroidhormonereceptorsignalingpathwayregulationofproteinmetabolicprocessresponsetoestrogenresponsetoglucocorticoidresponsetoinsulinsomatotropinsecretingcelldevelopmentwaterhomeostasis
T cell receptor beta constant 2
2.0
43
85
TRACA0A0G2JMB4P01848A0A0G2JMB4adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathway
HLA-B35
2.0
84
82
O19626O19626O19626O19626
Sodium channel subunit beta-1
2.0
76
80
SCN1BSCN1BQ07699Q07699axonguidancecardiacconductioncardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractioncelladhesioncorticospinalneuronaxonguidancelocomotionmembranedepolarizationmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringPurkinjemyocytecellactionpotentialneuronalactionpotentialpropagationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofsodiumiontransportregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarizationsodiumiontransmembranetransport
Calcium-activated potassium channel subunit beta-4
2.0
55
88
KCMB4KCMB4Q86W47Q86W47actionpotentialchemicalsynaptictransmissiondetectionofcalciumionneuronalactionpotentialpotassiumiontransportregulationofneurotransmittersecretionregulationofvasoconstriction
Dipeptidase 1
2.0
54
88
DPEP1DPEP1P16444P16444antibioticmetabolicprocesscellularresponsetocalciumioncellularresponsetonitricoxidecellularresponsetoxenobioticstimulusglutathionecatabolicprocessglutathionemetabolicprocesshomocysteinemetabolicprocessinflammatoryresponselactamcatabolicprocessleukotrieneD4catabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessneutrophilchemotaxisproteolysis
Transmembrane protease serine 11E
2.0
82
80
TM11ETM11EQ9UL52Q9UL52cognitionproteolysis
B protein
2.1
72
83
B2ZHY7B2ZHY7B2ZHY7B2ZHY7antigenprocessingandpresentationimmuneresponse
Granulocyte colony-stimulating factor
2.0
44
85
CSF3CSF3P35833P35833cellularresponsetocytokinestimulusimmuneresponsepositiveregulationofactincytoskeletonreorganizationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofmyeloidcelldifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinbindingpositiveregulationofproteinkinaseBsignalingpositiveregulationoftranscriptionbyRNApolymeraseII
Thioredoxin-interacting protein
2.1
nan
87
VAV2TXNIPP52735Q9H3M7angiogenesiscellmigrationcellularresponsetoxenobioticstimulusFc-epsilonreceptorsignalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosislamellipodiumassemblyplateletactivationpositiveregulationofphosphatidylinositol3-kinaseactivityregulationofcellsizeregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionsignaltransductionsmallGTPasemediatedsignaltransductionvascularendothelialgrowthfactorreceptorsignalingpathwaycellcyclecellularresponsetotumorcellkeratinocytedifferentiationnegativeregulationofcelldivisionnegativeregulationoftranscriptionbyRNApolymeraseIIplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticprocessproteinimportintonucleusproteintransportregulationofcellpopulationproliferationresponsetocalciumionresponsetoestradiolresponsetoglucoseresponsetohydrogenperoxideresponsetomechanicalstimulusresponsetoprogesteroneresponsetoxenobioticstimulus
Membrane primary amine oxidase
2.0
59
84
AOC3AOC3Q16853Q16853aminemetabolicprocesscelladhesioninflammatoryresponsenegativeregulationofprimaryamineoxidaseactivityresponsetoantibiotic
Protocadherin gamma B7
2.0
49
87
Q91XX3Q91XX3Q91XX3Q91XX3homophiliccelladhesionviaplasmamembraneadhesionmolecules
Complement C1s subcomponent
2.0
55
88
C1SC1SP09871P09871complementactivationclassicalpathwayinnateimmuneresponseproteolysis
Glutathione hydrolase 1 proenzyme
2.0
88
78
GGT1GGT1P19440P19440aminoacidmetabolicprocesscysteinebiosyntheticprocessfattyacidmetabolicprocessglutamatemetabolicprocessglutathionebiosyntheticprocessglutathionecatabolicprocessleukotrieneD4biosyntheticprocessleukotrienemetabolicprocesspeptidemodificationproteolysisregulationofimmunesystemprocessregulationofinflammatoryresponsespermatogenesiszymogenactivation
Pappalysin-1
2.0
nan
90
PAPP1PAPP1Q13219Q13219cellsurfacereceptorsignalingpathwayfemalepregnancyproteincatabolicprocessproteinmetabolicprocessproteolysisresponsetodexamethasoneresponsetofollicle-stimulatinghormone
MHC class 1
2.1
77
82
Q30291Q30291Q30291Q30291antigenprocessingandpresentationimmuneresponse
Isoform 3 of Metabotropic glutamate receptor 7
2.0
nan
94
GRM7GRM7Q14831-3Q14831-3
MHC class I heavy chain
2.0
nan
94
Q5KTQ2Q5KTQ2Q5KTQ2Q5KTQ2
Secretin receptor
2.0
57
85
SCTRSCTRP47872P47872adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaybraindevelopmentcellsurfacereceptorsignalingpathwaycellularwaterhomeostasisdietinducedthermogenesisGprotein-coupledreceptorsignalingpathwaypositiveregulationofcAMP-mediatedsignalingregulationofappetiteregulationofsynapticplasticityresponsetonutrientlevels
Immunoglobulin heavy constant alpha 2
2.0
39
86
IGHA2IGHA2P01877P01877adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Calcitonin gene-related peptide type 1 receptor
2.0
55
87
CALRLCALRLQ16602Q16602adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwayangiogenesiscalcitoningene-relatedpeptidereceptorsignalingpathwaycalciumiontransportcellsurfacereceptorsignalingpathwaycellularresponsetosucrosestimulusGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerheartdevelopmentnegativeregulationofinflammatoryresponsenegativeregulationofsmoothmusclecontractionpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteintransportreceptorinternalizationvascularassociatedsmoothmusclecellproliferation
Immunoglobulin heavy constant alpha 1
2.0
72
84
IGHA1IGHA1P01876P01876adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumglomerularfiltrationimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofrespiratoryburstretinahomeostasis
Gap junction alpha-3 protein
2.0
71
84
CXA3CXA3Q9TU17Q9TU17cellcommunicationgapjunction-mediatedintercellulartransportvisualperception
DEP domain-containing mTOR-interacting protein
2.0
42
86
DPTORDPTORQ8TB45Q8TB45intracellularsignaltransductionnegativeregulationofcellsizenegativeregulationofproteinkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingnegativeregulationofTORC2signalingregulationofextrinsicapoptoticsignalingpathway
Disintegrin and metalloproteinase domain-containing protein 17
2.0
55
89
ADA17ADA17P78536P78536amyloidprecursorproteincatabolicprocessBcelldifferentiationcelladhesioncelladhesionmediatedbyintegrincellmotilitycellularresponsetohighdensitylipoproteinparticlestimulusdefenseresponsetoGram-positivebacteriumepidermalgrowthfactorreceptorsignalingpathwaygerminalcenterformationmembraneproteinectodomainproteolysisnegativeregulationofcold-inducedthermogenesisnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayneutrophilmediatedimmunityNotchreceptorprocessingNotchsignalingpathwaypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofepidermalgrowthfactor-activatedreceptoractivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofleukocytechemotaxispositiveregulationofproteinphosphorylationpositiveregulationofTcellchemotaxispositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationoftumornecrosisfactor-mediatedsignalingpathwaypositiveregulationofvascularendothelialcellproliferationproteinprocessingproteolysisreceptortransactivationregulationofmastcellapoptoticprocessresponsetohypoxiaresponsetolipopolysaccharideresponsetoxenobioticstimulusspleendevelopmentTcelldifferentiationinthymuswoundhealingspreadingofepidermalcells
Pro-neuregulin-1, membrane-bound isoform
2.1
56
88
NRG1NRG1Q02297Q02297activationofproteinkinaseBactivityactivationoftransmembranereceptorproteintyrosinekinaseactivityanimalorgandevelopmentcardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationcellcommunicationcelldifferentiationcellpopulationproliferationendocardialcelldifferentiationERBBsignalingpathwayERBB2-ERBB3signalingpathwayERBB2-ERBB4signalingpathwayERBB3signalingpathwayERBB4signalingpathwayERBB4-ERBB4signalingpathwayintracellularsignaltransductionmammaryglanddevelopmentnegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofsecretionnervoussystemdevelopmentneuralcrestcelldevelopmentpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcelladhesionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofstriatedmusclecelldifferentiationregulationofpostsynapticneurotransmitterreceptorinternalizationsequesteringofmetaliontransmembranereceptorproteintyrosinekinasesignalingpathwayventricularcardiacmusclecelldifferentiationventriculartrabeculamyocardiummorphogenesiswoundhealing
MHC class I antigen
2.0
82
83
V6E0U6V6E0U6V6E0U6V6E0U6antigenprocessingandpresentationimmuneresponse
Leukocyte immunoglobulin-like receptor subfamily A member 3
2.0
77
82
LIRA3LIRA3Q8N6C8Q8N6C8adaptiveimmuneresponsecytokine-mediatedsignalingpathway
Cadherin-related family member 2
2.0
68
81
CDHR2CDHR2Q9BYE9Q9BYE9cell-celladhesioncell-celladhesionmediatedbycadherinepithelialcelldifferentiationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesintermicrovillaradhesionnegativeregulationofcellgrowthinvolvedincontactinhibitionregulationofmicrovilluslength
Dual specificity protein phosphatase 26
2.0
54
82
DUS26DUS26Q9BV47Q9BV47negativeregulationofERK1andERK2cascadenegativeregulationofMAPKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcelladhesionproteindephosphorylation
Solute carrier family 12 member 4
2.0
55
87
S12A4S12A4Q9UP95Q9UP95ammoniumimportacrossplasmamembranecellvolumehomeostasischemicalsynaptictransmissionchlorideionhomeostasischloridetransmembranetransportiontransportpotassiumionhomeostasispotassiumionimportacrossplasmamembranepotassiumiontransmembranetransport
Dipeptidyl aminopeptidase-like protein 6
2.0
64
87
DPP6DPP6P42658P42658proteinlocalizationtoplasmamembraneproteolysisregulationofpotassiumiontransmembranetransport
Sperm acrosome membrane-associated protein 6
2.0
nan
90
SACA6SACA6W5XKT8W5XKT8fusionofspermtoeggplasmamembraneinvolvedinsinglefertilization
Receptor activity-modifying protein 3
2.0
48
87
RAMP3RAMP3O60896O60896adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadrenomedullinreceptorsignalingpathwayamylinreceptorsignalingpathwaycalciumiontransportcellularresponsetoestradiolstimuluscellularresponsetohormonestimuluscross-receptorinhibitionwithinGprotein-coupledreceptorheterodimerGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayinvolvedinheartprocessintracellularproteintransportpositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcelldeathpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofreceptorrecyclingproteinlocalizationtoplasmamembraneproteintransportreceptorinternalizationresponsetoamyloid-beta
Endoglin
2.0
46
90
EGLNEGLNP17813P17813arterymorphogenesisatrialcardiacmuscletissuemorphogenesisatrioventricularcanalmorphogenesisBMPsignalingpathwaybonedevelopmentbranchinginvolvedinbloodvesselmorphogenesiscardiacatriummorphogenesiscardiacventriclemorphogenesiscelladhesioncellchemotaxiscellmigrationcellmigrationinvolvedinendocardialcushionformationcellmotilitycellularresponsetomechanicalstimuluscentralnervoussystemvasculogenesisdetectionofhypoxiadorsalaortamorphogenesisendocardialcushionmorphogenesisepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationextracellularmatrixconstituentsecretionextracellularmatrixdisassemblyheartloopingnegativeregulationofcellmigrationnegativeregulationofendothelialcellproliferationnegativeregulationofgeneexpressionnegativeregulationofnitric-oxidesynthaseactivitynegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofproteinautophosphorylationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayoutflowtractseptummorphogenesispositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofsystemicarterialbloodpressurepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularassociatedsmoothmusclecelldifferentiationregulationofcelladhesionregulationofcellpopulationproliferationregulationofDNA-templatedtranscriptionregulationofphosphorylationregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocorticosteroidresponsetohypoxiaresponsetoxenobioticstimulussmoothmuscletissuedevelopmenttransforminggrowthfactorbetareceptorsignalingpathwayvascularassociatedsmoothmusclecelldevelopmentvasculogenesisvenousbloodvesselmorphogenesisventriculartrabeculamyocardiummorphogenesiswoundhealing
Odz3 protein
2.0
nan
90
B7ZNJ5B7ZNJ5B7ZNJ5B7ZNJ5signaltransduction
Lactotransferrin
2.0
38
86
W8QEY1W8QEY1W8QEY1W8QEY1antibacterialhumoralresponseantifungalhumoralresponseossificationproteolysisregulationofcytokineproduction
Stromal cell-derived factor 1
2.0
36
89
H7BX38H7BX38H7BX38H7BX38adultlocomotorybehavioranimalorganregenerationchemokine(C-X-Cmotif)ligand12signalingpathwaydefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainimmuneresponseintegrinactivationnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcelladhesionpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofcalciumiontransportresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundtelencephaloncellmigration
Phospholipid-transporting ATPase ABCA1
2.0
45
85
ABCA1ABCA1O95477O95477adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetolipopolysaccharidecellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetoretinoicacidcholesteroleffluxcholesterolhomeostasischolesterolmetabolicprocessendosomaltransportexportacrossplasmamembraneGprotein-coupledreceptorsignalingpathwayhigh-densitylipoproteinparticleassemblyintracellularcholesteroltransportlipidtransportlysosomeorganizationnegativeregulationofcholesterolstoragenegativeregulationofmacrophagederivedfoamcelldifferentiationpeptidesecretionphagocytosisengulfmentphospholipideffluxphospholipidhomeostasisphospholipidtranslocationplateletdensegranuleorganizationpositiveregulationofcholesteroleffluxpositiveregulationofhigh-densitylipoproteinparticleassemblyproteinlipidationproteinsecretionproteintransmembranetransportregulationofCdc42proteinsignaltransductionregulationofhigh-densitylipoproteinparticleassemblyresponsetolaminarfluidshearstressreversecholesteroltransportsignalrelease
Plexin-C1
2.0
60
88
PLXC1PLXC1O60486O60486celladhesionnegativeregulationofcelladhesionpositiveregulationofaxonogenesisregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivityregulationofsynapsepruningsemaphorin-plexinsignalingpathwayinvolvedinaxonguidance
Pleiotrophin
2.0
31
89
PTNPTNP21246P21246bonemineralizationdecidualizationdendritearborizationdendriteregenerationestrouscycleintegrin-mediatedsignalingpathwaylearningleukocytechemotaxisinvolvedininflammatoryresponsememorynegativeregulationoflong-termsynapticpotentiationnegativeregulationofneuroblastproliferationnervoussystemdevelopmentoogenesisossificationinvolvedinboneremodelingpositiveregulationofaxonregenerationpositiveregulationofbonemineralizationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofdendritedevelopmentpositiveregulationofhepatocyteproliferationpositiveregulationofleukocytechemotaxispositiveregulationofneuronprojectiondevelopmentpositiveregulationofoligodendrocytedifferentiationpositiveregulationofossificationpositiveregulationofstemcelldifferentiationreceptorclusteringregulationofendothelialcellmigrationregulationofhemopoiesisregulationofmyelinationregulationofstemcellpopulationmaintenanceregulationofsynapticplasticityresponsetoauditorystimulustissueregenerationtransmembranereceptorproteintyrosinephosphatasesignalingpathway
Meckelin
2.0
55
88
MKS3MKS3Q5HYA8Q5HYA8ciliumassemblynegativeregulationofcentrosomeduplicationnon-canonicalWntsignalingpathwayubiquitin-dependentERADpathway
Choriogonadotropin subunit beta 3
2.0
45
90
CGB3CGB3P0DN86P0DN86apoptoticprocesscell-cellsignalingfemalegametegenerationGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwaysignaltransduction
Volume-regulated anion channel subunit LRRC8C
2.0
66
85
LRC8CLRC8CQ8R502Q8R502aniontransmembranetransportaspartatetransmembranetransportcellularresponsetoosmoticstresscyclic-GMP-AMPtransmembraneimportacrossplasmamembranefatcelldifferentiationproteinhexamerizationtaurinetransport
Interleukin-17 receptor B
2.0
50
87
I17RBI17RBQ9NRM6Q9NRM6defenseresponseregulationofcellgrowth
UL16-binding protein 3
2.0
74
82
ULBP3ULBP3Q9BZM4Q9BZM4naturalkillercellactivationnaturalkillercellmediatedcytotoxicity
ETS domain-containing transcription factor ERF
2.0
38
86
ERFERFP50548P50548celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
T cell receptor alpha chain constant
2.0
43
85
TRACA0A0G2JMB4P01848A0A0G2JMB4adaptiveimmuneresponsealpha-betaTcellactivationresponsetobacteriumTcellreceptorsignalingpathway
Serine protease HTRA1
2.0
33
88
HTRA1HTRA1Q92743Q92743chorionictrophoblastcelldifferentiationdentinogenesisnegativeregulationofBMPsignalingpathwaynegativeregulationofdefenseresponsetovirusnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofepithelialcellproliferationprogrammedcelldeathproteolysis
Beta-hexosaminidase subunit beta
2.0
63
88
HEXBHEXBp07686p07686astrocytecellmigrationcellularcalciumionhomeostasischondroitinsulfatecatabolicprocessdermatansulfatecatabolicprocessgangliosidecatabolicprocessglycosaminoglycanmetabolicprocesshyaluronancatabolicprocesslipidstoragelocomotorybehaviorlysosomeorganizationmaintenanceoflocationincellmalecourtshipbehaviormyelinationneuromuscularprocesscontrollingbalanceneuroncellularhomeostasisoligosaccharidecatabolicprocessoogenesispenetrationofzonapellucidaphospholipidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellshapesensoryperceptionofsoundsinglefertilizationskeletalsystemdevelopment
HLA class I histocompatibility antigen
2.0
82
82
Q1ELT0Q1ELT0Q1ELT0Q1ELT0antigenprocessingandpresentationimmuneresponse
Protein tweety homolog 3
2.0
68
83
TTYH3TTYH3Q9C0H2Q9C0H2chloridetransportiontransmembranetransport
Isoform 1 of Extracellular calcium-sensing receptor
2.0
56
89
CASRCASRP41180-1P41180-1
Metabotropic glutamate receptor 3
2.0
50
89
GRM3GRM3Q14832Q14832chemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwaygeneexpressionnegativeregulationofadenylatecyclaseactivitypostsynapticmodulationofchemicalsynaptictransmissionregulationofsynaptictransmissionglutamatergic
Thyrotropin subunit beta
2.0
48
90
TSHBTSHBP01222P01222anatomicalstructuremorphogenesiscell-cellsignalingGprotein-coupledreceptorsignalingpathwayhormone-mediatedsignalingpathwayresponsetocalciumionresponsetoestrogenresponsetovitaminA
Muscarinic acetylcholine receptor M3
2.0
62
86
ACM3ACM3P20309P20309acetylcholinereceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwaycalcium-mediatedsignalingchemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerionchannelmodulatingGprotein-coupledreceptorsignalingpathwayligand-gatedionchannelsignalingpathwaynervoussystemdevelopmentphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwaypositiveregulationofinsulinsecretionpositiveregulationofsmoothmusclecontractionproteinmodificationprocessregulationofiontransmembranetransporteractivityregulationofvascularassociatedsmoothmusclecontractionsalivasecretionsignaltransductionsmoothmusclecontraction
Exostosin-2
2.0
63
83
EXT2EXT2Q93063Q93063cellularpolysaccharidebiosyntheticprocesscellularresponsetofibroblastgrowthfactorstimuluschondrocytedifferentiationendochondralbonemorphogenesisfluidtransportgeneexpressionglycosaminoglycanbiosyntheticprocessheartcontractionheparansulfateproteoglycanbiosyntheticprocessheparansulfateproteoglycanbiosyntheticprocesspolysaccharidechainbiosyntheticprocessheparinbiosyntheticprocessmesodermformationmulticellularorganismalwaterhomeostasisossificationproteinN-linkedglycosylationregulationofbloodpressuresignaltransductionsodiumionhomeostasissulfationvasodilation
Gap junction alpha-1 protein
2.0
72
84
✔
CXA1CXA1P17302P17302atrialcardiacmusclecellactionpotentialbonedevelopmentboneremodelingcardiacconductionsystemdevelopmentcellcommunicationbyelectricalcouplingcellcommunicationbyelectricalcouplinginvolvedincardiacconductioncell-cellsignalingcellularresponsetoamyloid-betaestablishmentofmitoticspindleorientationexportacrossplasmamembranegapjunctionassemblyglutamatesecretioniontransmembranetransportmaintenanceofblood-brainbarriermicrotubule-basedtransportnegativeregulationofcellgrowthnegativeregulationofgonadotropinsecretionnegativeregulationoftrophoblastcellmigrationpositiveregulationofcold-inducedthermogenesispositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmesodermalcelldifferentiationpositiveregulationofmorphogenesisofanepitheliumpositiveregulationofstemcellproliferationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinlocalizationsignaltransductionspermatogenesisxenobiotictransport
NPC1-like intracellular cholesterol transporter 1
2.0
56
88
NPCL1NPCL1Q9UHC9Q9UHC9cellularresponsetosteroldepletioncholesterolbiosyntheticprocesscholesterolhomeostasischolesteroltransportintestinalcholesterolabsorptionlipoproteinmetabolicprocesssteroltransportvitaminEmetabolicprocessvitamintransport
Tumor necrosis factor receptor superfamily member 11B
2.0
65
89
TR11BTR11BO00300O00300apoptoticprocessextracellularmatrixorganizationnegativeregulationofboneresorptionnegativeregulationofodontogenesisofdentin-containingtoothnegativeregulationofosteoclastdifferentiationresponsetoarsenic-containingsubstanceresponsetoestrogenresponsetomagnesiumionresponsetonutrientresponsetoxenobioticstimulussignaltransductionskeletalsystemdevelopment
Tumor necrosis factor receptor superfamily member 9
2.0
nan
91
TNR9TNR9Q07011Q07011apoptoticprocessnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferationregulationofimmatureTcellproliferationinthymus
Transient receptor potential cation channel subfamily M member 2
2.0
61
85
TRPM2TRPM2O94759O94759calciumionimportacrossplasmamembranecalciumiontransmembraneimportintocytosolcalciumiontransmembranetransportcalciumiontransportcalcium-mediatedsignalingusingintracellularcalciumsourcecationtransmembranetransportcellularresponsetocalciumioncellularresponsetohydrogenperoxidecellularresponsetopurine-containingcompoundcellularresponsetotemperaturestimulusdendriticcellchemotaxisdendriticcelldifferentiationestrouscyclepositiveregulationofinsulinsecretionpositiveregulationofoxidativestress-inducedneurondeathproteinhomotetramerizationregulationofactincytoskeletonreorganizationregulationoffilopodiumassemblyreleaseofsequesteredcalciumionintocytosolresponsetoheatresponsetohydroperoxideresponsetopurine-containingcompoundtemperaturehomeostasiszinciontransmembranetransport
Osteopetrosis-associated transmembrane protein 1
2.0
nan
90
OSTM1OSTM1Q86WC4Q86WC4osteoclastdifferentiationtransepithelialchloridetransport
Guanine nucleotide-binding protein G(i) subunit alpha-1
2.0
49
85
GNAI1GNAI1P10824P10824adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaynegativeregulationofsynaptictransmissionpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganization
Mannose-binding protein C
2.0
70
82
MBL2MBL2P11226P11226acute-phaseresponseantiviralinnateimmuneresponsecellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplementactivationlectinpathwaydefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponsekillingbyhostofsymbiontcellsnegativeregulationofviralprocessopsonizationpositiveregulationofopsonizationproteolysisresponsetooxidativestress
Angiotensin-converting enzyme
2.0
71
82
A0A7T0Q2W2A0A7T0Q2W2A0A7T0Q2W2A0A7T0Q2W2proteolysis
Solute carrier family 12 member 7
2.0
47
89
S12A7S12A7Q9Y666Q9Y666ammoniumimportacrossplasmamembranecellvolumehomeostasiscellularresponsetoglucosestimuluschemicalsynaptictransmissionchlorideionhomeostasischloridetransmembranetransportiontransportpotassiumionhomeostasispotassiumionimportacrossplasmamembranepotassiumiontransmembranetransport
Nuclear body protein SP140
2.0
66
85
SP140SP140Q13342Q13342defenseresponseregulationoftranscriptionbyRNApolymeraseII
ATP-binding cassette, sub-family A (ABC1), member 1
2.0
47
88
B2RUU2B2RUU2B2RUU2B2RUU2lipidtransport
Glutaminyl-peptide cyclotransferase
2.0
94
76
QPCTQPCTQ9CYK2Q9CYK2peptidyl-pyroglutamicacidbiosyntheticprocessusingglutaminyl-peptidecyclotransferase
Phospholipid-transporting ATPase ABCA3
2.0
49
86
ABCA3ABCA3Q99758Q99758lipidtransportlungdevelopmentorganelleassemblyphosphatidylcholinemetabolicprocessphosphatidylglycerolmetabolicprocessphospholipidhomeostasisphospholipidtransportpositiveregulationofcholesteroleffluxpositiveregulationofphospholipideffluxpositiveregulationofphospholipidtransportpositiveregulationofproteinhomooligomerizationproteinmetabolicprocessregulationoflipidbiosyntheticprocessregulationofphosphatidylcholinemetabolicprocessresponsetoglucocorticoidresponsetoxenobioticstimulussurfactanthomeostasisxenobioticexportfromcellxenobiotictransmembranetransportxenobiotictransport
PRKCA-binding protein
2.0
80
79
Q6GQQ2Q6GQQ2Q6GQQ2Q6GQQ2monoaminetransportphosphorylationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofinsulinsecretion
Protein amnionless
2.0
51
86
AMNLSAMNLSQ9BXJ7Q9BXJ7cobalaminmetabolicprocesscobalamintransportGolgitoplasmamembraneproteintransportproteinlocalizationreceptor-mediatedendocytosisrenalproteinabsorption
Arylsulfatase B
2.0
nan
88
ARSBARSBP15848P15848autophagycentralnervoussystemdevelopmentcolonepithelialcellmigrationlysosomaltransportlysosomeorganizationpositiveregulationofneuronprojectiondevelopmentregulationofepithelialcellmigrationresponsetoestrogenresponsetomethylmercuryresponsetonutrientresponsetopH
Proto-oncogene tyrosine-protein kinase receptor Ret
2.0
nan
91
RETRETP07949P07949activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaxonguidancecellularresponsetoretinoicacidembryonicepithelialtubeformationentericnervoussystemdevelopmentglialcell-derivedneurotrophicfactorreceptorsignalingpathwayhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinnervationlymphocytemigrationintolymphoidorgansMAPKcascademembraneproteinproteolysisneuralcrestcellmigrationneuroncell-celladhesionneuronmaturation"Peyerspatchmorphogenesis"positiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellmigrationpositiveregulationofcellsizepositiveregulationofDNA-templatedtranscriptionpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmetanephricglomerulusdevelopmentpositiveregulationofneuronmaturationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationofSTATproteinpositiveregulationofproteinkinaseBsignalingposteriormidgutdevelopmentproteinphosphorylationregulationofaxonogenesisregulationofcelladhesionresponsetopainresponsetoxenobioticstimulusretinadevelopmentincamera-typeeyesignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathwayuretermaturationuretericbuddevelopment
Macrophage-expressed gene 1 protein
3.4
24
87
MPEG1MPEG1A1L314A1L314antibacterialinnateimmuneresponsedefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdisruptionbyhostofsymbiontmembrane
IgE L chain kappa
2.0
86
81
A0A0D5ZY64A0A0D5ZY64A0A0D5ZY64A0A0D5ZY64
Neuropeptide Y receptor type 4
2.0
72
82
NPY4RNPY4RP50391P50391Gprotein-coupledreceptorsignalingpathway
MHC class II antigen
2.0
80
80
S6B6U4S6B6U4S6B6U4S6B6U4adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Syncytin-2
2.0
56
87
SYCY2SYCY2P60508P60508myoblastfusionsyncytiumformationsyncytiumformationbyplasmamembranefusion
Signal-regulatory protein beta-1 isoform 3
2.0
78
81
SIRBLSIRBLQ5TFQ8Q5TFQ8
Integrin alpha-5
2.0
57
88
ITA5ITA5P08648P08648angiogenesisCD40signalingpathwaycelladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-celladhesionmediatedbyintegrincell-matrixadhesioncell-substrateadhesioncell-substratejunctionassemblyendodermalcelldifferentiationfemalepregnancyheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesheterotypiccell-celladhesionintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmemorynegativeregulationofanoikispositiveregulationofcellmigrationpositiveregulationofcell-substrateadhesionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofsproutingangiogenesispositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaywoundhealingspreadingofepidermalcells
IGK@ protein
2.0
nan
85
Q6PJF2IGHMQ6PJF2P01871adaptiveimmuneresponseantibacterialhumoralresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Insulin-like peptide INSL5
2.0
nan
91
REL3INSL5Q8WXF3Q9Y5Q6positiveregulationoffeedingbehavior
Exostosin-1
2.0
60
86
EXT1EXT1Q16394Q16394antigenprocessingandpresentationaxonguidancebasementmembraneorganizationbloodvesselremodelingBMPsignalingpathwayboneresorptioncanonicalWntsignalingpathwaycartilagedevelopmentinvolvedinendochondralbonemorphogenesiscelladhesionmediatedbyintegrincellfatecommitmentcellularpolysaccharidebiosyntheticprocesscellularresponsetoviruschondrocytehypertrophychondrocyteproliferationchondroitinsulfatemetabolicprocesscollagenfibrilorganizationcranialskeletalsystemdevelopmentdendriteself-avoidancedendriticcellmigrationdevelopmentalgrowthinvolvedinmorphogenesisembryonicskeletaljointdevelopmentendochondralbonegrowthendochondralossificationendodermdevelopmentepithelialtubebranchinginvolvedinlungmorphogenesisfearresponsefibroblastgrowthfactorreceptorsignalingpathwayfluidtransportgastrulationgeneexpressionglandularepithelialcelldifferentiationglomerularbasementmembranedevelopmentglycosaminoglycanbiosyntheticprocesshairfolliclemorphogenesisheartcontractionheartfieldspecificationhematopoieticstemcelldifferentiationhematopoieticstemcellhomeostasishematopoieticstemcellmigrationtobonemarrowheparansulfateproteoglycanbiosyntheticprocessheparansulfateproteoglycanbiosyntheticprocesspolysaccharidechainbiosyntheticprocessheparinbiosyntheticprocesshypersensitivityleukocytetetheringorrollinglimbjointmorphogenesislymphocyteadhesiontoendothelialcellofhighendothelialvenulelymphocytemigrationintolymphoidorgansmesenchymalcelldifferentiationinvolvedinbonedevelopmentmesodermdevelopmentmotorbehaviormulticellularorganismgrowthmulticellularorganismalwaterhomeostasisneuralcrestcelldifferentiationolfactorybulbdevelopmentopticnervedevelopmentossificationossificationinvolvedinbonematurationperichondralbonemorphogenesispodocytedifferentiationproteincatabolicprocessproteinglycosylationprotein-containingcomplexassemblyregulationofbloodpressureresponsetoheparinresponsetoleukemiainhibitoryfactorresponsetolightintensitysebaceousglanddevelopmentsignaltransductionskeletalsystemdevelopmentsmoothenedsignalingpathwayinvolvedinlungdevelopmentsocialbehaviorsodiumionhomeostasisstemcelldivisionstomachdevelopmentsulfationsweatglanddevelopmentsynaptictransmissionglutamatergictightjunctionorganizationTNFSF11-mediatedsignalingpathwayvacuoleorganizationvasodilationvocalizationbehaviorwoundhealing
NAD(P)H oxidase (H2O2-forming)
2.0
54
85
A2AQ92A2AQ92A2AQ92A2AQ92cuticledevelopmentcytokine-mediatedsignalingpathwaydefenseresponsehormonebiosyntheticprocesshydrogenperoxidebiosyntheticprocesshydrogenperoxidecatabolicprocesspositiveregulationofcellmotilitypositiveregulationofwoundhealingreactiveoxygenspeciesmetabolicprocessresponsetocAMPresponsetooxidativestresssuperoxideaniongenerationthyroidhormonegeneration
MHC class I antigen
2.1
82
83
F4NBT5F4NBT5F4NBT5F4NBT5
Ighg protein
2.0
85
80
Q91Z05Q91Z05Q91Z05Q91Z05
Glandular kallikrein
2.0
69
85
KLK1KLK1P06870P06870regulationofsystemicarterialbloodpressurezymogenactivation
Voltage-dependent calcium channel gamma-2 subunit
2.0
59
87
CCG2CCG2Q9Y698Q9Y698eyeblinkreflexmembranedepolarizationmembranehyperpolarizationneuromuscularjunctiondevelopmentneurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofproteinlocalizationtobasolateralplasmamembranepositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteintargetingtomembraneregulationofAMPAreceptoractivityresponsetocalciumiontransmissionofnerveimpulse
Coxsackievirus and adenovirus receptor
2.0
72
84
CXARCXARP78310P78310actincytoskeletonreorganizationAVnodecelltobundleofHiscellcommunicationAVnodecell-bundleofHiscelladhesioninvolvedincellcommunicationcardiacmusclecelldevelopmentcardiacmusclecellproliferationcell-celljunctionorganizationdefenseresponsetovirusepithelialstructuremaintenancegamma-deltaTcellactivationgermcellmigrationheartdevelopmentheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomotypiccell-celladhesionmitochondrionorganizationnegativeregulationofcardiacmusclecellproliferationneutrophilchemotaxisregulationofAVnodecellactionpotentialtransepithelialtransport
HLA class II histocompatibility antigen, DO beta chain
2.0
83
80
DOBDOBP13765P13765adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIInegativeregulationofantigenprocessingandpresentationofpeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
Leukocyte immunoglobulin-like receptor subfamily A member 2
2.0
77
83
LIRA2LIRA2Q8N149Q8N149cytokine-mediatedsignalingpathwaydefenseresponseinnateimmuneresponseinnateimmuneresponseactivatingcellsurfacereceptorsignalingpathwaynegativeregulationoflipopolysaccharide-mediatedsignalingpathwaynegativeregulationoftoll-likereceptor4signalingpathwayneutrophilactivationinvolvedinimmuneresponsepositiveregulationofcalciumiontransportpositiveregulationofcellactivationpositiveregulationofgranulocytecolony-stimulatingfactorproductionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationoftumornecrosisfactorproductionsignaltransduction
Sodium channel protein type 8 subunit alpha
2.0
32
87
SCN8ASCN8AQ9UQD0Q9UQD0membranedepolarizationduringactionpotentialmyelinationnervoussystemdevelopmentneuronalactionpotentialperipheralnervoussystemdevelopmentregulationofiontransmembranetransportsodiumiontransmembranetransportsodiumiontransport
Cytotoxic T-lymphocyte protein 4
2.0
60
84
Q28090Q28090Q28090Q28090BcellreceptorsignalingpathwaycellularresponsetoDNAdamagestimulusimmuneresponsenegativeregulationofBcellproliferationnegativeregulationofregulatoryTcelldifferentiationpositiveregulationofapoptoticprocessregulationofTcellproliferationTcellreceptorsignalingpathway
Sulfhydryl oxidase 1
2.0
49
88
QSOX1QSOX1O00391O00391extracellularmatrixassemblynegativeregulationofmacroautophagyproteinfolding
HECT-type E3 ubiquitin transferase
2.0
55
85
A0A024R9Y3A0A024R9Y3A0A024R9Y3A0A024R9Y3DNArepair
Interleukin-27 subunit beta
2.0
64
87
IL27BIL27BQ14213Q14213cytokine-mediatedsignalingpathwayhumoralimmuneresponseleptin-mediatedsignalingpathwaypositiveregulationofalpha-betaTcellproliferationpositiveregulationoftypeIIinterferonproductionTcellproliferationT-helper1typeimmuneresponse
Metabotropic glutamate receptor 4
2.0
48
89
GRM4GRM4Q14833Q14833adenylatecyclase-inhibitingGprotein-coupledglutamatereceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwayneurotransmittersecretionpositiveregulationofMAPKcascaderegulationofneuronapoptoticprocessregulationofsynaptictransmissionglutamatergic
cDNA FLJ56409, highly similar to Serine/threonine-protein kinase Chk1
2.0
45
85
B4DT73B4DT73B4DT73B4DT73proteinphosphorylation
Frizzled-5
2.1
57
84
FZD5FZD5Q13467Q13467angiogenesisanterior/posterioraxisspecificationembryoapoptoticprocessinvolvedinmorphogenesisbranchinginvolvedinlabyrinthinelayermorphogenesiscanonicalWntsignalingpathwaycellularresponsetomoleculeofbacterialoriginchorionictrophoblastcelldifferentiationembryonicaxisspecificationembryoniccamera-typeeyemorphogenesisglandularepithelialcellmaturationintestinalepithelialcellmaturationlabyrinthinelayerbloodvesseldevelopmentnegativeregulationofcellpopulationproliferationneurondifferentiationpositiveregulationofinterleukin-1betaproductionpositiveregulationofJUNkinaseactivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofTcellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpost-embryoniccamera-typeeyedevelopmentregulationofautophagyofmitochondrionregulationofbicellulartightjunctionassemblyregulationofchorionictrophoblastcellproliferationSpemannorganizerformationsynapseassemblysyncytiotrophoblastcelldifferentiationinvolvedinlabyrinthinelayerdevelopmentTcelldifferentiationinthymus
Ig lamda chain variable region
2.0
98
79
A0A6B9SCH7A0A6B9SCH7A0A6B9SCH7A0A6B9SCH7
MHC class I antigen
2.0
75
83
F4NBU6F4NBU6F4NBU6F4NBU6
Protein kinase C-binding protein NELL2
2.0
nan
94
NELL2NELL2Q99435Q99435fertilizationneuroncellularhomeostasis
Thioredoxin domain-containing protein 17
2.0
64
87
✔
TXD17TXD17Q9BRA2Q9BRA2tumornecrosisfactor-mediatedsignalingpathway
Desmoglein-2
2.0
49
86
DSG2DSG2Q14126Q14126bundleofHiscell-Purkinjemyocyteadhesioninvolvedincellcommunicationcelladhesioncell-celladhesiondesmosomeorganizationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesPurkinjemyocytedevelopmentregulationofheartratebycardiacconductionregulationofventricularcardiacmusclecellactionpotential
Growth arrest-specific protein 1
2.0
nan
91
GAS1GAS1P54826P54826cellcyclecellfatecommitmentcellularresponsetovascularendothelialgrowthfactorstimulusdevelopmentalgrowthnegativeregulationofmitoticcellcyclenegativeregulationofproteinprocessingregulationofapoptoticprocessregulationofERtoGolgivesicle-mediatedtransportregulationofsmoothenedsignalingpathway
Cell surface glycoprotein MUC18
2.0
74
84
MUC18MUC18P43121P43121anatomicalstructuremorphogenesisangiogenesiscelladhesionglomerularfiltrationpositiveregulationofcellmigrationvascularwoundhealing
Lymphocyte antigen HLA-B27
2.1
80
82
A0A2R7Z5J3A0A2R7Z5J3A0A2R7Z5J3A0A2R7Z5J3antigenprocessingandpresentationimmuneresponse
Ceroid-lipofuscinosis, neuronal 5, isoform CRA_a
2.0
55
85
A0A024R644A0A024R644A0A024R644A0A024R644
Transcription intermediary factor 1-alpha
4.0
53
87
TIF1ATIF1AO15164O15164calciumionhomeostasiscellularresponsetoestrogenstimulusepithelialcellproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationpositiveregulationofgeneexpressionproteinautophosphorylationproteincatabolicprocessproteinubiquitinationregulationofapoptoticprocessregulationofproteinstabilityregulationofsignaltransductionbyp53classmediatorregulationofvitaminDreceptorsignalingpathwaytranscriptionbyRNApolymeraseII
Disintegrin and metalloproteinase domain-containing protein 22
2.0
57
87
ADA22ADA22Q9P0K1Q9P0K1celladhesioncentralnervoussystemdevelopmentnegativeregulationofcelladhesionproteolysis
MHC class I antigen
2.1
78
83
F4NBT2F4NBT2F4NBT2F4NBT2
Histamine H3 receptor
2.1
63
84
HRH3HRH3Q9Y5N1Q9Y5N1adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwaychemicalsynaptictransmissioncognitionGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernegativeregulationofglutamatesecretionnegativeregulationofserotoninsecretionneurotransmittersecretionregulationofnorepinephrinesecretion
Beta-defensin 103
2.0
53
87
D103AD103AP81534P81534antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumkillingbyhostofsymbiontcellskillingofcellsofanotherorganism
Glutamate receptor ionotropic, NMDA 2D
2.0
66
85
NMDE4NMDE4O15399O15399adultlocomotorybehaviorbraindevelopmentcalciumiontransmembraneimportintocytosolcationtransmembranetransportexcitatorychemicalsynaptictransmissionexcitatorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaylong-termsynapticpotentiationpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofsynaptictransmissionglutamatergicregulationofcationtransmembranetransportregulationofneuronalsynapticplasticityregulationofsensoryperceptionofpainregulationofsynapticplasticitystartleresponsesynaptictransmissionglutamatergic
Mitogen-activated protein kinase 14
2.0
55
87
MK14MK14Q16539Q16539"3-UTR-mediatedmRNAstabilization"angiogenesisapoptoticprocessbonedevelopmentcartilagecondensationcellmorphogenesiscellsurfacereceptorsignalingpathwaycellularresponsetoionizingradiationcellularresponsetolipopolysaccharidecellularresponsetolipoteichoicacidcellularresponsetotumornecrosisfactorcellularresponsetoUV-BcellularresponsetovascularendothelialgrowthfactorstimuluscellularresponsetoviruscellularsenescencechemotaxischondrocytedifferentiationDNAdamagecheckpointsignalingfattyacidoxidationglucoseimportglucosemetabolicprocessintracellularsignaltransductionlipopolysaccharide-mediatedsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofhipposignalingnegativeregulationofinflammatoryresponsetoantigenicstimulusosteoblastdifferentiationosteoclastdifferentiationp38MAPKcascadepeptidyl-serinephosphorylationplacentadevelopmentplateletactivationpositiveregulationofbrownfatcelldifferentiationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcyclaseactivitypositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofinterleukin-12productionpositiveregulationofmusclecelldifferentiationpositiveregulationofmyoblastdifferentiationpositiveregulationofmyoblastfusionpositiveregulationofmyotubedifferentiationpositiveregulationofproteinimportintonucleuspositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcytokineproductioninvolvedininflammatoryresponseregulationofossificationregulationofsynapticmembraneadhesionregulationoftranscriptionbyRNApolymeraseIIresponsetodietaryexcessresponsetoinsulinresponsetomuramyldipeptideresponsetomusclestretchsignaltransductionsignaltransductioninresponsetoDNAdamageskeletalmuscletissuedevelopmentstemcelldifferentiationstress-activatedMAPKcascadestress-inducedprematuresenescencestriatedmusclecelldifferentiationtranscriptionbyRNApolymeraseIItransmembranereceptorproteinserine/threoninekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
H2-M beta 2
2.0
69
81
Q31099Q31099Q31099Q31099adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIchaperonecofactor-dependentproteinrefoldingMHCclassIIproteincomplexassemblypeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcellpositiveregulationofTcellproliferation
Vascular endothelial growth factor C
2.0
57
88
VEGFCVEGFCP49767P49767animalorganmorphogenesiscellularresponsetoleukemiainhibitoryfactorglialcellproliferationinductionofpositivechemotaxismorphogenesisofembryonicepitheliumnegativeregulationofbloodpressurenegativeregulationofosteoblastdifferentiationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofglialcellproliferationpositiveregulationoflymphangiogenesispositiveregulationofmastcellchemotaxispositiveregulationofmesenchymalstemcellproliferationpositiveregulationofneuroblastproliferationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesissubstrate-dependentcellmigrationvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Major prion protein
2.0
76
84
Q6VS46Q6VS46Q6VS46Q6VS46proteinhomooligomerization
Neuroligin-3
2.0
67
85
NLGN3NLGN3Q8BYM5Q8BYM5adultbehavioraxonextensionchemicalsynaptictransmissioncircadiansleep/wakecycleexcitatorypostsynapticpotentialinhibitorypostsynapticpotentiallearninglong-termsynapticpotentiationmodulationofchemicalsynaptictransmissionnegativeregulationofdendriticspinemorphogenesisnegativeregulationofexcitatorypostsynapticpotentialneuroncell-celladhesionoligodendrocytedifferentiationpositiveregulationofAMPAreceptoractivitypositiveregulationofdendriticspinedevelopmentpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofinhibitorypostsynapticpotentialpositiveregulationofproteinlocalizationtosynapsepositiveregulationofsynapseassemblypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofsynapticvesicleclusteringpostsynapticmembraneassemblypostsynapticspecializationassemblyprepulseinhibitionpresynapticmembraneassemblyreceptor-mediatedendocytosisregulationofAMPAreceptoractivityregulationofdendriticspinemorphogenesisregulationoflong-termsynapticpotentiationregulationofNMDAreceptoractivityregulationofrespiratorygaseousexchangebynervoussystemprocessregulationofsynaptictransmissionglutamatergicregulationofterminalbuttonorganizationrhythmicsynaptictransmissionsocialbehaviorsynapseassemblysynapseorganizationsynapticvesicleendocytosisvisuallearningvocalizationbehavior
MHC class I antigen
2.0
82
81
F6IQA6F6IQA6F6IQA6F6IQA6
Tumor necrosis factor receptor superfamily member 6
2.0
nan
94
TNR6TNR6P25445P25445activation-inducedcelldeathofTcellsapoptoticprocesscellularresponsetoaminoacidstarvationcellularresponsetohyperoxiacellularresponsetomechanicalstimulusextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayinabsenceofligandFassignalingpathwayimmuneresponsemotorneuronapoptoticprocessnecroptoticsignalingpathwaynegativeregulationofapoptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaypositiveregulationofproteinphosphorylationprotein-containingcomplexassemblyregulationofapoptoticprocessregulationofstress-activatedMAPKcascadesignaltransduction
Coagulation factor V
2.0
64
85
FA5FA5P12259P12259bloodcirculationbloodcoagulationbloodcoagulationcommonpathwaybloodcoagulationextrinsicpathwayproteolysisresponsetovitaminKzymogenactivation
Sodium/potassium-transporting ATPase subunit beta-1
2.0
61
86
AT1B1AT1B1P05026P05026ATPmetabolicprocesscardiacmusclecontractioncationtransmembranetransportcelladhesioncellcommunicationbyelectricalcouplinginvolvedincardiacconductioncellularcalciumionhomeostasiscellularpotassiumionhomeostasiscellularsodiumionhomeostasisestablishmentormaintenanceoftransmembraneelectrochemicalgradientinnateimmuneresponsemembranerepolarizationmembranerepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofATP-dependentactivitypositiveregulationofcalciumpositiveregulationofP-typesodiumpositiveregulationofpotassiumionimportacrossplasmamembranepositiveregulationofpotassiumiontransmembranetransporteractivitypositiveregulationofsodiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembraneproteinlocalizationtoplasmamembraneproteinstabilizationproteintransportintoplasmamembraneraftprotontransmembranetransportregulationofcardiacmusclecontractionbycalciumionsignalingregulationofgeneexpressionrelaxationofcardiacmuscleresponsetohypoxiasodiumionexportacrossplasmamembranesodiumiontransmembranetransport
Complement component C9
2.0
nan
89
CO9CO9P02748P02748cellkillingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysispositiveregulationofimmuneresponseproteinhomooligomerization
Voltage-dependent T-type calcium channel subunit alpha-1I
2.0
49
89
CAC1ICAC1IQ9P0X4Q9P0X4calciumionimportmembranedepolarizationduringactionpotentialneuronalactionpotentialpositiveregulationofcalciumion-dependentexocytosisregulationofiontransmembranetransportsignaltransductionsleep
Insulin receptor-related protein
2.0
58
89
INSRRINSRRP14616P14616actincytoskeletonreorganizationcellularresponsetoalkalinepHmalesexdeterminationpositiveregulationofkinaseactivityproteinautophosphorylationtransmembranereceptorproteintyrosinekinasesignalingpathway
Progranulin
2.0
nan
91
GRNGRNP28799P28799astrocyteactivationinvolvedinimmuneresponselysosomallumenacidificationlysosomaltransportlysosomeorganizationmicroglialcellactivationinvolvedinimmuneresponsenegativeregulationofmicroglialcellactivationnegativeregulationofneuronapoptoticprocessnegativeregulationofneutrophilactivationnegativeregulationofrespiratoryburstinvolvedininflammatoryresponsepositiveregulationofangiogenesispositiveregulationofaspartic-typepeptidaseactivitypositiveregulationofaxonregenerationpositiveregulationofcellmigrationpositiveregulationofdefenseresponsetobacteriumpositiveregulationofendothelialcellmigrationpositiveregulationofepithelialcellproliferationpositiveregulationofinflammatoryresponsetowoundingpositiveregulationoflysosomeorganizationpositiveregulationofneuronapoptoticprocesspositiveregulationofproteinfoldingproteinstabilizationregulationofinflammatoryresponsesignaltransduction
Glutamate receptor ionotropic, NMDA 2A
2.0
70
84
NMDE1NMDE1Q12879Q12879activationofcysteine-typeendopeptidaseactivitybraindevelopmentcalciumiontransmembraneimportintocytosolcationtransmembranetransportchemicalsynaptictransmissiondirectionallocomotiondopaminemetabolicprocessexcitatorychemicalsynaptictransmissionexcitatorypostsynapticpotentialglutamatereceptorsignalingpathwayionotropicglutamatereceptorsignalingpathwaylearningormemorylong-termsynapticpotentiationmemorynegativeregulationofproteincatabolicprocessneurogenesispositiveregulationofapoptoticprocesspositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofsynaptictransmissionglutamatergicproteincatabolicprocessproteinlocalizationtopostsynapticmembraneregulationofcationtransmembranetransportregulationofneuronalsynapticplasticityregulationofsynapticplasticityresponsetoamphetamineresponsetoethanolresponsetowoundingresponsetoxenobioticstimulussensoryperceptionofpainserotoninmetabolicprocesssleepstartleresponsevisuallearning
Platelet-derived growth factor receptor alpha
2.0
76
83
PGFRAPGFRAP16234P16234adrenalglanddevelopmentcardiacmyofibrilassemblycellactivationcellchemotaxiscellularresponsetoaminoacidstimuluscellularresponsetoreactiveoxygenspeciesembryoniccranialskeletonmorphogenesisembryonicdigestivetractmorphogenesisembryonicskeletalsystemmorphogenesisestrogenmetabolicprocessextracellularmatrixorganizationfacemorphogenesishematopoieticprogenitorcelldifferentiationinuteroembryonicdevelopmentLeydigcelldifferentiationlungdevelopmentluteinizationmalegenitaliadevelopmentmetanephricglomerularcapillaryformationnegativeregulationofplateletactivationodontogenesisofdentin-containingtoothpeptidyl-tyrosinephosphorylationphosphatidylinositol-mediatedsignalingplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwayplatelet-derivedgrowthfactorreceptor-alphasignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofkinaseactivitypositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivityproteinautophosphorylationregulationofactincytoskeletonreorganizationregulationofchemotaxisregulationofmesenchymalstemcelldifferentiationretinavasculaturedevelopmentincamera-typeeyeroofofmouthdevelopmentsignaltransductioninvolvedinregulationofgeneexpressiontransmembranereceptorproteintyrosinekinasesignalingpathwaywhitefatcelldifferentiationwoundhealing
Angiotensin-converting enzyme
2.0
53
84
E2DHI3E2DHI3E2DHI3E2DHI3proteolysis
Gamma-aminobutyric acid receptor subunit alpha-1
2.0
71
82
GBRA1GBRA1P62813P62813cellularresponsetohistaminechemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticchloridetransmembranetransportgamma-aminobutyricacidsignalingpathwayinhibitorysynapseassemblyiontransmembranetransportnervoussystemprocessregulationofmembranepotentialregulationofpostsynapticmembranepotentialsignaltransductionsynaptictransmissionGABAergic
Dopamine beta-hydroxylase
2.0
32
87
DOPODOPOP09172P09172behavioralresponsetoethanolbloodvesselremodelingchemicalsynaptictransmissiondopaminecatabolicprocessfearresponseglucosehomeostasishomoiothermyleukocytemediatedimmunityleukocytemigrationlocomotorybehaviormaternalbehaviormemorynorepinephrinebiosyntheticprocessoctopaminebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofvasoconstrictionregulationofextrinsicapoptoticsignalingpathwayregulationofvascularassociatedsmoothmusclecellproliferationregulationofvascularendothelialcellproliferationresponsetoamphetamineresponsetopainvasoconstrictionvisuallearning
MHC class I polypeptide-related sequence A
2.0
63
87
MICAMICAQ9TQ92Q9TQ92cellularresponsetoDNAdamagestimuluscytolysisdefenseresponsetobacteriumdefenseresponsetovirusgamma-deltaTcellactivationimmuneresponsetotumorcellnaturalkillercellmediatedcytotoxicitynegativeregulationofnaturalkillercellactivationnegativeregulationofnaturalkillercellmediatedcytotoxicityresponsetoheatTcellmediatedcytotoxicity
Potassium channel TASK2
2.0
36
84
Q9JK62Q9JK62Q9JK62Q9JK62potassiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportregulationofrestingmembranepotentialstabilizationofmembranepotential
CD1A protein
2.0
62
85
Q8N5T0Q8N5T0Q8N5T0Q8N5T0
Integrin alpha-6
2.0
52
85
ITA6ITA6P23229P23229celladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesioncell-substrateadhesioncell-substratejunctionassemblyectodermalcelldifferentiationintegrin-mediatedsignalingpathwayleukocytemigrationnaildevelopmentnegativeregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofcellmigrationpositiveregulationofGTPaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIskinmorphogenesis
G protein-activated inward rectifier potassium channel 2
2.0
59
85
Q8C4T8Q8C4T8Q8C4T8Q8C4T8regulationofiontransmembranetransport
Follistatin-related protein 1
2.0
45
88
FSTL1FSTL1Q62356Q62356celldifferentiationendothelialcelldifferentiationendothelialcellmigrationhematopoieticstemcellhomeostasisnegativeregulationofapoptoticprocessregulationofBMPsignalingpathway
Acrosin
2.0
66
87
ACROACROP08001P08001acrosomereactionactivationofadenylatecyclaseactivityproteolysissinglefertilization
Anti-Muellerian hormone type-2 receptor
2.0
79
82
AMHR2AMHR2Q16671Q16671activinreceptorsignalingpathwayanti-MullerianhormonesignalingpathwaycellularresponsetogrowthfactorstimulusfemalegonaddevelopmentmalegonaddevelopmentMullerianductregressionpathway-restrictedSMADproteinphosphorylationproteinphosphorylationsexdifferentiationtransforminggrowthfactorbetareceptorsignalingpathway
Protein wntless homolog
2.0
57
90
WLSWLSQ5T9L3Q5T9L3anterior/posterioraxisspecificationcementummineralizationexocrinepancreasdevelopmenthindbraindevelopmentintracellularproteintransportmesodermformationmidbraindevelopmentpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofWntproteinsecretionpositiveregulationofWntsignalingpathwayWntproteinsecretionWntsignalingpathway
Agouti-related protein
2.0
50
89
AGRPAGRPO00253O00253adultfeedingbehaviorcircadianrhythmeatingbehaviorfeedingbehaviorhormone-mediatedsignalingpathwaylong-dayphotoperiodismmaternalprocessinvolvedinfemalepregnancyneuropeptidesignalingpathwaypositiveregulationoffeedingbehaviorregulationoffeedingbehaviorresponsetoinsulin
Protein-tyrosine sulfotransferase 1
2.0
70
86
TPST1TPST1O60507O60507"3-phosphoadenosine5-phosphosulfatemetabolicprocess"inflammatoryresponsepeptidyl-tyrosinesulfation
MHC class I antigen
2.0
80
83
F4NBQ8F4NBQ8F4NBQ8F4NBQ8
C-C chemokine receptor type 1
2.0
61
86
CCR1CCR1P32246P32246calciumiontransportcalcium-mediatedsignalingcelladhesioncellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasischemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydendriticcellchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponseinflammatoryresponsenegativeregulationofbonemineralizationnegativeregulationofgeneexpressionpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofmonocytechemotaxispositiveregulationofosteoclastdifferentiationresponsetowounding
D(2) dopamine receptor
2.0
41
83
DRD2DRD2P14416P14416acidsecretionactivationofproteinkinaseactivityadenohypophysisdevelopmentadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-inhibitingdopaminereceptorsignalingpathwayadultwalkingbehaviorarachidonicacidsecretionassociativelearningauditorybehaviorautophagyaxonogenesisbehavioralresponsetococainebehavioralresponsetoethanolbranchingmorphogenesisofanervecellularcalciumionhomeostasiscerebralcortexGABAergicinterneuronmigrationcircadianregulationofgeneexpressiondopaminemetabolicprocessdopamineuptakeinvolvedinsynaptictransmissiondrinkingbehaviorepithelialcellproliferationexcitatorypostsynapticpotentialGprotein-coupledreceptorinternalizationgroomingbehaviorhyaloidvascularplexusregressionintracellularsignaltransductionlocomotorybehaviorlong-termmemorynegativeregulationofadenylatecyclaseactivitynegativeregulationofbloodpressurenegativeregulationofcelldeathnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofcircadiansleep/wakecyclesleepnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofdopaminereceptorsignalingpathwaynegativeregulationofdopaminesecretionnegativeregulationofepithelialcellproliferationnegativeregulationofinnateimmuneresponsenegativeregulationofinsulinsecretionnegativeregulationofneuronmigrationnegativeregulationofproteinkinaseBsignalingnegativeregulationofproteinphosphorylationnegativeregulationofproteinsecretionnegativeregulationofsynaptictransmissionglutamatergicnegativeregulationofvoltage-gatedcalciumchannelactivitynervoussystemprocessinvolvedinregulationofsystemicarterialbloodpressureneuroblastproliferationneuron-neuronsynaptictransmissionorbitofrontalcortexdevelopmentperistalsisphospholipaseC-activatingdopaminereceptorsignalingpathwaypigmentationpositiveregulationofcytokinesispositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofdopamineuptakeinvolvedinsynaptictransmissionpositiveregulationofERK1andERK2cascadepositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglialcell-derivedneurotrophicfactorproductionpositiveregulationofgrowthhormonesecretionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofmulticellularorganismgrowthpositiveregulationofneuroblastproliferationpositiveregulationofreceptorinternalizationpositiveregulationofrenalsodiumexcretionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepostsynapticmodulationofchemicalsynaptictransmissionprepulseinhibitionpresynapticmodulationofchemicalsynaptictransmissionproteinkinaseBsignalingproteinlocalizationregulationofdopaminesecretionregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofheartrateregulationoflocomotioninvolvedinlocomotorybehaviorregulationoflong-termneuronalsynapticplasticityregulationofphosphoproteinphosphataseactivityregulationofpotassiumiontransportregulationofsodiumiontransportregulationofsynapsestructuralplasticityregulationofsynaptictransmissionGABAergicreleaseofsequesteredcalciumionintocytosolresponsetoamphetamineresponsetoaxoninjuryresponsetococaineresponsetohistamineresponsetohypoxiaresponsetoinactivityresponsetoironionresponsetolightstimulusresponsetomorphineresponsetonicotineresponsetotoxicsubstanceresponsetoxenobioticstimulussensoryperceptionofsmellstriatumdevelopmentsynapseassemblytemperaturehomeostasisvisuallearningWntsignalingpathway
MHC class II antigen IEk-beta
2.0
79
80
Q31163Q31163Q31163Q31163adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassII
Inositol 1,4,5-trisphosphate receptor type 3
2.0
70
84
ITPR3ITPR3Q14573Q14573Gprotein-coupledreceptorsignalingpathwaylong-termsynapticpotentiationmemorypositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolresponsetocalciumionsensoryperceptionofbittertastesensoryperceptionofsweettastesensoryperceptionoftastesensoryperceptionofumamitaste
Phosphopantothenoylcysteine decarboxylase
2.0
52
83
COACCOACQ96CD2Q96CD2coenzymeAbiosyntheticprocess
Calcium homeostasis modulator protein 5
2.0
55
88
CAHM5CAHM5Q8N5C1Q8N5C1
Glutamate receptor ionotropic, NMDA 2C
2.0
61
86
NMDE3NMDE3Q14957Q14957braindevelopmentcalciumiontransmembraneimportintocytosolcationtransmembranetransportdirectionallocomotionexcitatorychemicalsynaptictransmissionexcitatorypostsynapticpotentialglutamatereceptorsignalingpathwayionotropicglutamatereceptorsignalingpathwaylong-termsynapticpotentiationnegativeregulationofproteincatabolicprocessneuromuscularprocesscontrollingbalancepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofsynaptictransmissionglutamatergicproteinlocalizationtopostsynapticmembraneregulationofcationtransmembranetransportregulationofneuronalsynapticplasticityregulationofsynapticplasticityresponsetowounding
Insulin-like 3
2.0
48
86
INSL3INSL3P51460P51460adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycell-cellsignalingmalegonaddevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationoocytematurationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofwoundhealingspermatogenesis
B- and T-lymphocyte attenuator
2.0
nan
90
BTLABTLAQ7Z6A9Q7Z6A9adaptiveimmuneresponseimmuneresponse-regulatingcellsurfacereceptorsignalingpathway
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
2.0
67
85
BST1BST1Q10588Q10588humoralimmuneresponsepositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationregulationofactincytoskeletonorganizationregulationofcalcium-mediatedsignalingregulationofcell-matrixadhesionregulationofcellularextravasationregulationofinflammatoryresponseregulationofintegrin-mediatedsignalingpathwayregulationofneutrophilchemotaxisregulationofpeptidyl-tyrosinephosphorylationregulationofsuperoxidemetabolicprocesssignaltransduction
Voltage-dependent L-type calcium channel subunit alpha-1D
2.0
60
87
CAC1DCAC1DQ01668Q01668adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycalciumionimportcalciumionimportacrossplasmamembranecalciumiontransmembranetransportcalciumiontransportcardiacmusclecellactionpotentialinvolvedincontractionmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringSAnodecellactionpotentialpositiveregulationofadenylatecyclaseactivitypositiveregulationofcalciumiontransportregulationofatrialcardiacmusclecellmembranerepolarizationregulationofheartratebycardiacconductionregulationofpotassiumiontransmembranetransportregulationofpotassiumiontransmembranetransporteractivitysensoryperceptionofsound
Gastrin/cholecystokinin type B receptor
4.0
nan
84
GASRGASRP32239P32239cellsurfacereceptorsignalingpathwaycholecystokininsignalingpathwaydigestivetractdevelopmentGprotein-coupledreceptorsignalingpathwaygastricacidsecretionglanddevelopmentpHreductionphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentration
MHC class I antigen
2.0
79
83
C6ZK72C6ZK72C6ZK72C6ZK72antigenprocessingandpresentationimmuneresponse
Transforming growth factor beta activator LRRC32
2.0
61
86
LRC32LRC32Q14392Q14392negativeregulationofactivatedTcellproliferationnegativeregulationofcytokineproductionpositiveregulationofgeneexpressionregulationoftransforminggrowthfactorbetaactivationregulationoftransforminggrowthfactorbeta3activationsecondarypalatedevelopmenttransforminggrowthfactorbetareceptorsignalingpathway
T-lymphocyte activation antigen CD80
2.0
72
82
CD80CD80P33681P33681cellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharideimmuneresponseintracellularsignaltransductionnegativeregulationofTcellproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-2productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofsignaltransductionpositiveregulationofTcellproliferationpositiveregulationofT-helper1celldifferentiationTcellcostimulation
TPSB2 protein
2.0
69
83
Q6NZY1Q6NZY1Q6NZY1Q6NZY1proteolysis
Receptor-interacting serine/threonine-protein kinase 3
2.0
56
82
✔
RIPK3RIPK3Q9Y572Q9Y572activationofproteinkinaseactivityamyloidfibrilformationapoptoticsignalingpathwaycellularresponsetohydrogenperoxidedefenseresponsetovirusexecutionphaseofnecroptosisI-kappaBkinase/NF-kappaBsignalinglymphnodedevelopmentnecroptoticprocessnecroptoticsignalingpathwaypositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofligaseactivitypositiveregulationofnecroptoticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofoxidoreductaseactivitypositiveregulationofphosphataseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocessprogrammednecroticcelldeathproteinautophosphorylationproteinmodificationprocessreactiveoxygenspeciesmetabolicprocessregulationofactivatedTcellproliferationregulationofactivation-inducedcelldeathofTcellsregulationofadaptiveimmuneresponseregulationofapoptoticprocessregulationofCD8-positivealpha-betacytotoxicTcellextravasationregulationofTcellmediatedcytotoxicityregulationoftypeIIinterferonproductionsignaltransductionspleendevelopmentTcelldifferentiationinthymusTcellhomeostasisthymusdevelopment
CX3C chemokine receptor 1
2.0
57
86
CX3C1CX3C1P49238P49238adaptiveimmuneresponseantifungalinnateimmuneresponseautocrinesignalingbraindevelopmentcalcium-mediatedsignalingcelladhesioncellchemotaxiscell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidecellularresponsetotransforminggrowthfactorbetastimuluscentralnervoussystemmaturationchemotaxisGprotein-coupledreceptorsignalingpathwayhost-mediatedregulationofintestinalmicrobiotacompositionimmuneresponseinnateimmuneresponseleukocytechemotaxisleukocytetetheringorrollingmemorymicroglialcellactivationinvolvedinimmuneresponsemodulationofchemicalsynaptictransmissionmultiplespinesynapseorganizationsingledendritenegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofhippocampalneuronapoptoticprocessnegativeregulationofinterleukin-1betaproductionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmicroglialcellmediatedcytotoxicityphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofI-kappaBphosphorylationpositiveregulationofmicroglialcellmigrationpositiveregulationofmonocytechemotaxispositiveregulationofneuroblastproliferationpositiveregulationofneurogenesispositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinkinaseBsignalingregulationofmicroglialcellmigrationregulationofneurogenesisregulationofnitricoxidebiosyntheticprocessregulationofsynapticplasticityregulationoftumornecrosisfactorproductionresponsetoischemiaresponsetowoundingsocialbehaviorsynapsematurationsynapsepruning
Ephrin type-B receptor 2
2.0
69
88
✔
EPHB2EPHB2P54763P54763angiogenesisanimalorganmorphogenesisaxonguidanceaxonalfasciculationaxonogenesisBcellactivationcamera-typeeyemorphogenesiscellmorphogenesiscellularresponsetoamyloid-betacellularresponsetolipopolysaccharidecentralnervoussystemprojectionneuronaxonogenesiscommissuralneuronaxonguidancecorpuscallosumdevelopmentdendriticspinedevelopmentdendriticspinemorphogenesisephrinreceptorsignalingpathwayhindbraintangentialcellmigrationinnerearmorphogenesislearninglearningormemorynegativeregulationofaxonogenesisnegativeregulationofcelladhesionnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofERK1andERK2cascadenegativeregulationofNMDAglutamatereceptoractivitynegativeregulationofproteinkinaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofRasproteinsignaltransductionneuronprojectionretractionopticnervemorphogenesispeptidyl-tyrosinephosphorylationphosphorylationpositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofdendriticspinemorphogenesispositiveregulationofgeneexpressionpositiveregulationofimmunoglobulinproductionpositiveregulationofkinaseactivitypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationoflong-termsynapticpotentiationpositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofproteinlocalizationtocellsurfacepositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofsynapseassemblypositiveregulationofsynapticplasticitypositiveregulationoftumornecrosisfactorproductionpostsynapticmembraneassemblyproteinphosphorylationregulationofaxonogenesisregulationofbehavioralfearresponseregulationofbloodcoagulationregulationofbodyfluidlevelsregulationoffilopodiumassemblyregulationofneuronalsynapticplasticityregulationofreceptorsignalingpathwayviaJAK-STATregulationofsynapseassemblyregulationofT-helper17typeimmuneresponseretinalganglioncellaxonguidanceroofofmouthdevelopmenttightjunctionassemblytrans-synapticsignalingbytrans-synapticcomplexmodulatingsynaptictransmissiontransmembranereceptorproteintyrosinekinasesignalingpathwayurogenitalsystemdevelopmentvesicle-mediatedintercellulartransport
Neprilysin
2.0
56
88
NEPNEPP08473P08473agingamyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessamyloid-betametabolicprocessbradykinincatabolicprocesscellularresponsetocytokinestimuluscellularresponsetoUV-AcellularresponsetoUV-Bcreatininemetabolicprocesshormonecatabolicprocesskidneydevelopmentlearningormemorylungdevelopmentneuropeptideprocessingpeptidemetabolicprocessplacentadevelopmentpositiveregulationoflong-termsynapticpotentiationpositiveregulationofneurogenesisproteincatabolicprocessproteinprocessingproteolysisreplicativesenescenceresponsetoestrogensensoryperceptionofpainsubstancePcatabolicprocess
Glutamate receptor
2.0
54
85
C9K0Z0C9K0Z0C9K0Z0C9K0Z0
Tumor necrosis factor receptor superfamily member 10A
2.0
54
89
TR10ATR10AO00220O00220activationofNF-kappaB-inducingkinaseactivityapoptoticprocesscellularresponsetomechanicalstimulusextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofapoptoticprocesssignaltransductionTRAIL-activatedapoptoticsignalingpathway
Contactin-2
2.0
79
82
CNTN2CNTN2Q02246Q02246adultwalkingbehavioraxonguidanceaxonalfasciculationcelladhesioncentralnervoussystemmyelinationcerebralcortexGABAergicinterneuronmigrationclusteringofvoltage-gatedpotassiumchannelsdendriteself-avoidanceestablishmentoflocalizationincellestablishmentofproteinlocalizationtojuxtaparanoderegionofaxonfatcelldifferentiationGprotein-coupledadenosinereceptorsignalingpathwayhomophiliccelladhesionviaplasmamembraneadhesionmoleculeslearningmicrotubulecytoskeletonorganizationnegativeregulationofneurondifferentiationpositiveregulationofadenosinereceptorsignalingpathwaypositiveregulationofproteinprocessingpresynapticmembraneorganizationproteinlocalizationtojuxtaparanoderegionofaxonproteinprocessingreceptorinternalizationreductionoffoodintakeinresponsetodietaryexcessregulationofastrocytedifferentiationregulationofaxondiameterregulationofcellmorphogenesisinvolvedindifferentiationregulationofneuronalsynapticplasticity
Somatostatin receptor type 4
2.0
72
83
SSR4SSR4P31391P31391cellmigrationcellularresponsetoglucocorticoidstimulusforebraindevelopmentGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernegativeregulationofadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaynegativeregulationofcellpopulationproliferationneuropeptidesignalingpathwaypositiveregulationofarachidonicacidsecretionpositiveregulationofERK1andERK2cascade
Hepatitis A virus cellular receptor 2
2.0
66
84
Q3KP82Q3KP82Q3KP82Q3KP82
NALCN channel auxiliary factor 1
2.0
nan
91
NALF1NALF1B1AL88B1AL88calciumionimportacrossplasmamembrane
Solute carrier family 12 member 6
2.0
72
81
S12A6S12A6Q9UHW9Q9UHW9ammoniumimportacrossplasmamembraneangiogenesiscellvolumehomeostasiscellularhypotonicresponsecellularhypotonicsalinityresponsecellularresponsetoglucosestimuluschemicalsynaptictransmissionchlorideionhomeostasischloridetransmembranetransportiontransportpotassiumionhomeostasispotassiumionimportacrossplasmamembranepotassiumiontransmembranetransport
Exostosin-like 3
2.0
47
87
EXTL3EXTL3O43909O43909heparansulfateproteoglycanbiosyntheticprocesspositiveregulationofcellgrowthproteinglycosylation
Solute carrier family 12 member 5
2.0
47
89
S12A5S12A5Q9H2X9Q9H2X9cellvolumehomeostasiscellularchlorideionhomeostasiscellularionhomeostasischemicalsynaptictransmissionchlorideionhomeostasischloridetransmembranetransportdendriticspinedevelopmenthypotonicresponseintracellularpHreductioniontransportlearningmulticellularorganismgrowthpotassiumionhomeostasispotassiumionimportacrossplasmamembraneresponsetoxenobioticstimulusthermosensorybehavior
Pannexin-1
2.0
86
80
PANX1PANX1Q96RD7Q96RD7calciumiontransportcationtransportcell-cellsignalingoogenesispositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmacrophagecytokineproductionresponsetoATPresponsetoischemia
Voltage-dependent N-type calcium channel subunit alpha-1B
2.0
59
87
CAC1BCAC1BQ00975Q00975calciumionimportacrossplasmamembranechemicalsynaptictransmissionmodulationofchemicalsynaptictransmissionregulationofiontransmembranetransportresponsetoamyloid-beta
DNA-(apurinic or apyrimidinic site) endonuclease
2.0
58
86
✔
THIOAPEX1P10599P27695activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiationagingbase-excisionrepairbase-excisionrepairgap-fillingcellularresponsetocAMPcellularresponsetohydrogenperoxidecellularresponsetopeptidehormonestimulusDNAcatabolicprocessendonucleolyticDNAdemethylationDNArecombinationDNArepairnegativeregulationofsmoothmusclecellmigrationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofapoptoticprocessregulationofmRNAstabilityresponsetoxenobioticstimulustelomeremaintenancetelomeremaintenanceviabase-excisionrepair
Frizzled-4
2.0
nan
90
FZD4FZD4Q9ULV1Q9ULV1canonicalWntsignalingpathwaycellularresponsetoleukemiainhibitoryfactorcellularresponsetoretinoicacidcerebellumvasculaturemorphogenesisextracellularmatrix-cellsignalinglocomotioninvolvedinlocomotorybehaviornegativeregulationofcell-substrateadhesionneurondifferentiationnon-canonicalWntsignalingpathwayNorrinsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofdendritemorphogenesispositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofJUNkinaseactivitypositiveregulationofneuronprojectionarborizationprogesteronesecretionregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayretinavasculaturemorphogenesisincamera-typeeyeretinalbloodvesselmorphogenesissensoryperceptionofsoundsubstrateadhesion-dependentcellspreadingvasculogenesisWntsignalingpathwayWntsignalingpathwaycalciummodulatingpathway
Phospholipid-transporting ATPase ABCA7
2.0
50
86
ABCA7ABCA7Q8IZY2Q8IZY2amyloid-betaclearancebycellularcatabolicprocessamyloid-betaformationapolipoproteinA-I-mediatedsignalingpathwaycholesteroleffluxhigh-densitylipoproteinparticleassemblylipidtransportmemorynegativeregulationofamyloidprecursorproteinbiosyntheticprocessnegativeregulationofamyloid-betaformationnegativeregulationofendocytosisnegativeregulationofMAPKcascadenegativeregulationofPERK-mediatedunfoldedproteinresponsepeptidecross-linkingphagocytosisphospholipideffluxphospholipidtranslocationplasmamembraneraftorganizationpositiveregulationofamyloid-betaclearancepositiveregulationofcholesteroleffluxpositiveregulationofengulfmentofapoptoticcellpositiveregulationofERK1andERK2cascadepositiveregulationofphagocytosispositiveregulationofphospholipideffluxpositiveregulationofproteinlocalizationtocellsurfaceproteinlocalizationtonucleusregulationofamyloidprecursorproteincatabolicprocessregulationoflipidmetabolicprocessvisuallearning
Angiotensin-converting enzyme
2.0
55
82
A0A452CBT6A0A452CBT6A0A452CBT6A0A452CBT6proteolysis
Atypical chemokine receptor 3
2.0
64
84
ACKR3ACKR3P25106P25106angiogenesiscalcium-mediatedsignalingcelladhesioncellchemotaxischemokine-mediatedsignalingpathwayimmuneresponsenegativeregulationofcellpopulationproliferationnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageoculomotornervedevelopmentpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofmesenchymalstemcellmigrationreceptorinternalizationvasculogenesis
Monocyte differentiation antigen CD14
2.0
61
86
CD14CD14P10810P10810cellularresponsetodiacylbacteriallipopeptidecellularresponsetolipopolysaccharidecellularresponsetolipoteichoicacidcellularresponsetomoleculeofbacterialorigincellularresponsetotriacylbacteriallipopeptideinflammatoryresponseinnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaypositiveregulationofcytokineproductionpositiveregulationofendocytosispositiveregulationofinterleukin-8productionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftoll-likereceptor4signalingpathwaypositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIIinterferonproductionreceptor-mediatedendocytosisresponsetobacteriumresponsetoelectricalstimulusresponsetoethanolresponsetoheatresponsetomagnesiumionresponsetomoleculeofbacterialoriginresponsetotumornecrosisfactortoll-likereceptor4signalingpathway
Protein JTB
2.0
52
89
JTBJTBO76095O76095apoptoticmitochondrialchangesmitoticcellcyclemitoticcytokinesispositiveregulationofproteinkinaseactivityregulationofcellpopulationproliferation
Huntingtin
2.0
nan
94
HDHDP42858P42858apoptoticprocessestablishmentofmitoticspindleorientationGolgiorganizationmicrotubule-basedtransportnegativeregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofaggrephagypositiveregulationofapoptoticprocesspositiveregulationofautophagyofmitochondrionpositiveregulationofciliumassemblypositiveregulationofinositol145-trisphosphate-sensitivecalcium-releasechannelactivitypositiveregulationoflipophagyproteindestabilizationregulationofCAMKK-AMPKsignalingcascaderegulationofcAMP-dependentproteinkinaseactivityregulationofphosphoproteinphosphataseactivityretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumvesicletransportalongmicrotubulevocallearning
Kinesin-like protein KIF20A
2.0
46
86
KI20AKI20AO95235O95235microtubulebundleformationmicrotubule-basedmovementmidbodyabscissionmitoticcytokinesisproteintransportregulationofcytokinesis
Gamma-aminobutyric acid type B receptor subunit 2
2.0
65
85
GABR2GABR2O75899O75899adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwaygamma-aminobutyricacidsignalingpathwaynegativeregulationofadenylatecyclaseactivityneuron-glialcellsignalingsynaptictransmissionGABAergic
NPC1 like intracellular cholesterol transporter 1
2.0
57
88
A0A0C4DFX6A0A0C4DFX6A0A0C4DFX6A0A0C4DFX6cholesterolimportresponsetomuscleactivityresponsetoxenobioticstimulusvitamintransport
Cell cycle control protein 50B
2.0
73
85
CC50BCC50BQ3MIR4Q3MIR4aminophospholipidtransportphospholipidtranslocationpositiveregulationofproteinexitfromendoplasmicreticulum
Glutamate receptor ionotropic, delta-1
2.0
35
87
GRID1GRID1Q62640Q62640modulationofchemicalsynaptictransmissionregulationofpostsynapseorganizationsocialbehaviorsynaptictransmissionglutamatergic
Solute carrier family 12 member 3
2.0
48
88
S12A3S12A3P55017P55017cellvolumehomeostasiscellularresponsetoinorganicsubstancechlorideionhomeostasischloridetransmembranetransportiontransportpotassiumionhomeostasispotassiumionimportacrossplasmamembraneproteinphosphorylationresponsetoaldosteroneresponsetodietaryexcesssignaltransductionsodiumionhomeostasissodiumiontransmembranetransportsodiumiontransport
Insulin-like growth factor-binding protein 4
2.0
43
88
IBP4IBP4P22692P22692inflammatoryresponseMAPKcascadenegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascaderegulationofcellgrowthregulationofglucosemetabolicprocessregulationofinsulin-likegrowthfactorreceptorsignalingpathwayresponsetoorganiccycliccompoundsignaltransductiontypeBpancreaticcellproliferation
Metabotropic glutamate receptor 2
2.0
52
89
GRM2GRM2Q14416Q14416behavioralresponsetonicotinecellularglutamatehomeostasischemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwaygeneexpressionglutamatesecretionlong-termsynapticdepressionnegativeregulationofadenylatecyclaseactivitypresynapticmodulationofchemicalsynaptictransmissionregulationofdopaminesecretionregulationofglutamatesecretionregulationofproteinkinaseBsignalingregulationofresponsetodrugregulationofsynaptictransmissionglutamatergicresponsetococaine
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
2.0
58
86
✔
RPN2RPN2P04844P04844agingproteinmodificationprocessproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineresponsetoxenobioticstimulus
CD44 antigen
2.0
46
84
CD44CD44Q16208Q16208cartilagedevelopmentcelladhesioncellmigrationcell-celladhesioncell-matrixadhesioncellularresponsetofibroblastgrowthfactorstimuluscytokine-mediatedsignalingpathwayhyaluronancatabolicprocessinflammatoryresponsemonocyteaggregationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorpositiveregulationofERK1andERK2cascadepositiveregulationofheterotypiccell-celladhesionpositiveregulationofmonocyteaggregationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationregulationoflamellipodiummorphogenesisTcellactivationwoundhealingspreadingofcells
Cystatin-D
2.0
54
88
CYTDCYTDP28325P28325negativeregulationofcysteine-typeendopeptidaseactivity
Cytochrome b-245 heavy chain
2.0
62
84
CY24BCY24BP04839P04839cellularresponsetocadmiumioncellularresponsetoethanolcellularresponsetoL-glutaminedefenseresponseelectrontransportchainhydrogenperoxidebiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofangiogenesispositiveregulationoftumornecrosisfactorproductionregulationofiontransmembranetransportrespiratoryburstresponsetoaldosteroneresponsetoangiotensinresponsetonutrientresponsetoxenobioticstimulussuperoxideaniongenerationsuperoxidemetabolicprocess
Sodium-dependent neutral amino acid transporter B(0)AT1
2.0
42
87
S6A19S6A19Q695T7Q695T7aminoacidtransportresponsetonutrientsodiumiontransmembranetransportvirallifecycle
Lymphocyte antigen 75
2.0
48
87
LY75LY75O60449O60449endocytosisimmuneresponseinflammatoryresponse
Mas-related G-protein coupled receptor member X1
2.0
52
85
MRGX1MRGX1Q96LB2Q96LB2acute-phaseresponsecellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayresponsetochloroquinesignaltransduction
Leucine-rich repeat and fibronectin type-III domain-containing protein 5
2.0
52
89
LRFN5LRFN5Q8BXA0Q8BXA0negativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationregulationofpresynapseassemblysynapticmembraneadhesion
Protocadherin gamma A9
2.0
50
86
Q91XX9Q91XX9Q91XX9Q91XX9celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
Desmocollin-2
2.0
48
87
DSC2DSC2Q02487Q02487bundleofHiscell-Purkinjemyocyteadhesioninvolvedincellcommunicationcardiacmusclecell-cardiacmusclecelladhesioncelladhesioncell-celladhesioncellularresponsetostarvationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesregulationofheartratebycardiacconductionregulationofventricularcardiacmusclecellactionpotential
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
2.0
63
84
NDST1NDST1P52848P52848aortadevelopmentcardiacseptumdevelopmentcellpopulationproliferationcoronaryvasculaturedevelopmentembryonicneurocraniummorphogenesisembryonicviscerocraniummorphogenesisfibroblastgrowthfactorreceptorsignalingpathwayforebraindevelopmentheparansulfateproteoglycanbiosyntheticprocessenzymaticmodificationheparansulfateproteoglycanbiosyntheticprocesspolysaccharidechainbiosyntheticprocessheparinbiosyntheticprocessinflammatoryresponsemidbraindevelopmentpositiveregulationofMAPKcascadepositiveregulationofsmoothenedsignalingpathwayproteinsulfationrespiratorygaseousexchangebyrespiratorysystem
Toll-like receptor 7
2.0
52
86
TLR7TLR7Q9NYK1Q9NYK1cellularresponsetomechanicalstimuluscellularresponsetovirusdefenseresponsetovirusI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationinflammatoryresponseinnateimmuneresponseJNKcascadepositiveregulationofchemokineproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionregulationofproteinphosphorylationresponsetocGMPtoll-likereceptor7signalingpathwaytoll-likereceptorsignalingpathway
MHC class I antigen
2.0
83
83
I3ZN85I3ZN85I3ZN85I3ZN85antigenprocessingandpresentationimmuneresponse
Interferon alpha-8
2.0
nan
89
IFNA8IFNA8P32881P32881adaptiveimmuneresponseBcelldifferentiationBcellproliferationcellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirushumoralimmuneresponsenaturalkillercellactivationinvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationofSTATproteinresponsetoexogenousdsRNATcellactivationinvolvedinimmuneresponsetypeIinterferon-mediatedsignalingpathway
4F2 cell-surface antigen heavy chain
2.0
40
88
4F2XCTJ3KPF3Q9UPY5aminoacidtransportcalciumiontransportcarbohydratemetabolicprocessisoleucinetransportL-alanineimportacrossplasmamembraneL-histidinetransportL-leucineimportacrossplasmamembraneleucineimportacrossplasmamembraneleucinetransportmethioninetransportphenylalaninetransportprolinetransportresponsetoexogenousdsRNAthyroidhormonetransporttryptophantransporttyrosinetransportvalinetransportviralentryintohostcelladultbehaviorcellularglutamatehomeostasiscellularresponsetooxidativestressdipeptideimportacrossplasmamembraneglutathionemetabolicprocessglutathionetransmembranetransportL-cystinetransportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportL-kynureninetransmembranetransportlensfibercelldifferentiationlimbdevelopmentlungalveolusdevelopmentmodulationofchemicalsynaptictransmissionnegativeregulationofferroptosisnegativeregulationofoxidativestress-inducedneurondeathplateletaggregationregulationofAMPAglutamatereceptorclusteringregulationofcellpopulationproliferationregulationofcysteinemetabolicprocessregulationofglutamatemetabolicprocessregulationofglutathionebiosyntheticprocessregulationofmelaninbiosyntheticprocessregulationofneutrophilapoptoticprocessregulationofproteintransportregulationofsynapseorganizationresponsetonicotineresponsetoorganiccycliccompoundresponsetoredoxstateresponsetotoxicsubstancestriatumdevelopmentventricularsystemdevelopmentvisuallearning
MHC class I antigen
2.1
81
83
A0A7T3RIQ2A0A7T3RIQ2A0A7T3RIQ2A0A7T3RIQ2
MHC class I antigen
2.0
87
81
A0A5H2UU57A0A5H2UU57A0A5H2UU57A0A5H2UU57antigenprocessingandpresentationimmuneresponse
Adhesion G-protein coupled receptor D1
2.0
71
84
AGRD1AGRD1Q6QNK2Q6QNK2adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathway
Semaphorin-6A
2.0
nan
94
SEM6ASEM6AO35464O35464apoptoticprocessaxonguidancecellsurfacereceptorsignalingpathwaycellularresponsetovascularendothelialgrowthfactorstimuluscentrosomelocalizationnegativechemotaxisnegativeregulationofangiogenesisnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofcelladhesioninvolvedinsproutingangiogenesisnegativeregulationofERK1andERK2cascadenegativeregulationofsproutingangiogenesisnegativeregulationofvascularendothelialgrowthfactorsignalingpathwayneuralcrestcellmigrationneuronmigrationpositiveregulationofcellmigrationpositiveregulationofneuronmigrationsemaphorin-plexinsignalingpathway
Eukaryotic translation initiation factor 5B
2.0
75
82
G1TRL5G1TRL5G1TRL5G1TRL5
Proprotein convertase subtilisin/kexin type 9
2.0
69
85
PCSK9PCSK9Q8NBP7Q8NBP7apoptoticprocesscellularresponsetoinsulinstimuluscellularresponsetostarvationcholesterolhomeostasischolesterolmetabolicprocesskidneydevelopmentlipoproteinmetabolicprocessliverdevelopmentlow-densitylipoproteinparticlereceptorcatabolicprocesslysosomaltransportnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationoflow-densitylipoproteinparticlereceptorbindingnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofreceptorinternalizationnegativeregulationofreceptorrecyclingnegativeregulationofreceptor-mediatedendocytosisinvolvedincholesteroltransportnegativeregulationofsodiumiontransmembranetransporteractivityneurogenesisneurondifferentiationphospholipidmetabolicprocesspositiveregulationoflow-densitylipoproteinparticlereceptorcatabolicprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofreceptorinternalizationproteinautoprocessingregulationofneuronapoptoticprocessregulationofsignalingreceptoractivitytriglyceridemetabolicprocess
SLIT and NTRK-like protein 1
2.0
50
88
SLIK1SLIK1Q96PX8Q96PX8adultbehavioraxonogenesishomeostaticprocessmulticellularorganismgrowthpositiveregulationofaxonogenesispositiveregulationofsynapseassemblyregulationofpresynapseassemblysynapseassemblysynapticmembraneadhesion
Klotho
2.0
67
82
KLOTKLOTQ9UEF7Q9UEF7acuteinflammatoryresponseagingcalciumionhomeostasiscarbohydratemetabolicprocessenergyreservemetabolicprocessfibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofsystemicarterialbloodpressurenorepinephrinebiosyntheticprocesspositiveregulationofbonemineralizationpositiveregulationofMAPKKKcascadebyfibroblastgrowthfactorreceptorsignalingpathwayresponsetoactivityresponsetoangiotensinresponsetovitaminD
Sodium/glucose cotransporter 2
2.0
46
88
SC5A2SC5A2P31639P31639alpha-glucosidetransportcarbohydratemetabolicprocessglucoseimportacrossplasmamembranehexosetransmembranetransportrenalglucoseabsorptionsodiumionimportacrossplasmamembranesodiumiontransport
Scavenger receptor class A member 5
2.1
52
89
SCAR5SCAR5Q6ZMJ2Q6ZMJ2cellularironionhomeostasiscellularresponsetoheatendocytosisironiontransmembranetransportproteinhomotrimerization
G protein-activated inward rectifier potassium channel 2
2.0
59
85
A0A338P6L0A0A338P6L0A0A338P6L0A0A338P6L0regulationofiontransmembranetransport
Mannan-binding lectin serine protease 1
2.0
55
88
MASP1MASP1P48740P48740cellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationlectinpathwaynegativeregulationofcomplementactivationpositiveregulationofopsonizationproteolysis
Gamma-aminobutyric acid type A receptor subunit gamma2
2.0
74
84
A0A1W2PQX1A0A1W2PQX1A0A1W2PQX1A0A1W2PQX1gamma-aminobutyricacidsignalingpathway
Glycosyl hydrolase family 13 catalytic domain-containing protein
2.0
nan
87
A0A6P7DVK7A0A6P7DVK7A0A6P7DVK7A0A6P7DVK7carbohydratemetabolicprocess
Short transient receptor potential channel 5
3.8
31
86
TRPC5TRPC5Q9UL62Q9UL62calciumiontransmembranetransportcalciumiontransportnegativeregulationofdendritemorphogenesisnervoussystemdevelopmentneuronapoptoticprocessneurondifferentiationphosphatidylserineexposureonapoptoticcellsurfacepositiveregulationofaxonextensionpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofneurondifferentiationpositiveregulationofpeptidyl-threoninephosphorylationregulationofcytosoliccalciumionconcentrationregulationofmembranehyperpolarization
Netrin receptor UNC5A
2.0
nan
91
UNC5AUNC5AQ6ZN44Q6ZN44anterior/posterioraxonguidanceapoptoticprocessaxonguidancenetrin-activatedsignalingpathwayneuronprojectiondevelopment
Protein unc-93 homolog B1
2.0
80
82
UN93BUN93BQ9H1C4Q9H1C4antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIcellmorphogenesisdefenseresponsetovirusinnateimmuneresponseintracellularproteintransportpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionTcellantigenprocessingandpresentationtoll-likereceptor3signalingpathwaytoll-likereceptor7signalingpathwaytoll-likereceptor9signalingpathwaytoll-likereceptorsignalingpathway
Delta-like protein 4
2.0
56
89
DLL4DLL4Q9NR61Q9NR61angiogenesisaorticvalvemorphogenesisbloodcirculationbloodvessellumenizationbloodvesselremodelingbranchinginvolvedinbloodvesselmorphogenesiscardiacatriummorphogenesiscardiacventriclemorphogenesiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetovascularendothelialgrowthfactorstimulusdorsalaortamorphogenesisnegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofendothelialcellmigrationnegativeregulationofgeneexpressionnegativeregulationofNotchsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIINotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwaypericardiummorphogenesispositiveregulationofgeneexpressionpositiveregulationofneuralprecursorcellproliferationpositiveregulationofNotchsignalingpathwayregulationofneuralretinadevelopmentregulationofneurogenesissignaltransductionTcelldifferentiationventralspinalcordinterneuronfatecommitmentventriculartrabeculamyocardiummorphogenesisvisualperception
fMet-Leu-Phe receptor
2.0
64
85
FPR1FPR1P21462P21462adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaychemotaxiscomplementreceptormediatedsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponsenitricoxidemediatedsignaltransductionphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationsignaltransduction
Glutamate receptor
2.0
57
85
G5E8H1G5E8H1G5E8H1G5E8H1
Vasopressin V2 receptor
2.0
31
85
V2RV2RP30518P30518activationofadenylatecyclaseactivityadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayhemostasisI-kappaBkinase/NF-kappaBsignalingnegativeregulationofcellpopulationproliferationnegativeregulationofrenalsodiumexcretionpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsystemicarterialbloodpressurepositiveregulationofvasoconstrictionregulationofsystemicarterialbloodpressurebyvasopressinrenalwaterretentionresponsetocytokinetelencephalondevelopment
B2 bradykinin receptor
2.0
82
82
BKRB2BKRB2P30411P30411arachidonicacidsecretionbloodcirculationcellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponseintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressbyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressbyp53classmediatornegativeregulationofpeptidyl-serinephosphorylationpositiveregulationofcytosoliccalciumionconcentrationregulationofvascularpermeabilityregulationofvasoconstrictionresponsetosaltstresssmoothmusclecontractiontransmembranereceptorproteintyrosinekinasesignalingpathwayvasoconstrictionvasodilation
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
2.0
77
80
F1SV23F1SV23F1SV23F1SV23mitochondrialrespiratorychaincomplexIassembly
Membrane cofactor protein
2.0
nan
90
MCPMCPP15529P15529adaptiveimmuneresponsecomplementactivationclassicalpathwayinnateimmuneresponsenegativeregulationofcomplementactivationclassicalpathwaynegativeregulationofgeneexpressionpositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofmemoryTcelldifferentiationpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationoftransforminggrowthfactorbetaproductionregulationofNotchsignalingpathwaysequesteringofextracellularligandfromreceptorsinglefertilizationTcellmediatedimmunity
IgLON family member 5
2.0
74
84
IGLO5IGLO5A6NGN9A6NGN9
MHC class I chain-related protein A
2.0
84
80
Q96QC4Q96QC4Q96QC4Q96QC4
Hepatocyte growth factor activator
2.0
nan
86
HGFAHGFAQ04756Q04756bloodcoagulationproteolysiszymogenactivation
Bile salt-activated lipase
2.0
57
84
CELCELP19835P19835ceramidecatabolicprocessintestinalcholesterolabsorptionlipidmetabolicprocesspancreaticjuicesecretion
Growth hormone secretagogue receptor type 1
2.0
70
84
GHSRGHSRQ92847Q92847actinpolymerizationordepolymerizationadultfeedingbehaviorcellularresponsetoinsulinstimuluscellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetolipopolysaccharidecellularresponsetothyroidhormonestimulusdecidualizationGprotein-coupledreceptorsignalingpathwayghrelinsecretiongrowthhormonesecretionhormone-mediatedsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaylearningormemorynegativeregulationofappetitenegativeregulationofinflammatoryresponsenegativeregulationofinsulinsecretionnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-6productionnegativeregulationoflocomotioninvolvedinlocomotorybehaviornegativeregulationofmacrophageapoptoticprocessnegativeregulationofnorepinephrinesecretionnegativeregulationoftumornecrosisfactorproductionpositiveregulationofappetitepositiveregulationofeatingbehaviorpositiveregulationoffattyacidmetabolicprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofmulticellularorganismgrowthpositiveregulationofsmallintestinaltransitpositiveregulationofsmallintestinesmoothmusclecontractionpositiveregulationofsproutingangiogenesispositiveregulationofvascularendothelialcellproliferationpostsynapticmodulationofchemicalsynaptictransmissionregulationofgastricmotilityregulationofgrowthhormonesecretionregulationofhindgutcontractionregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofpostsynapseorganizationregulationofsynapseassemblyregulationoftransmissionofnerveimpulseresponsetodexamethasoneresponsetoestradiolresponsetofollicle-stimulatinghormoneresponsetofoodresponsetogrowthhormoneresponsetohormoneresponsetomonosodiumglutamatespermatogenesis
CD1b molecule
2.2
72
82
Q1L1H6Q1L1H6Q1L1H6Q1L1H6antigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbpositiveregulationofTcellmediatedcytotoxicity
Cell surface hyaluronidase
2.0
48
90
CEIP2CEIP2Q9UHN6Q9UHN6angiogenesishyaluronancatabolicprocessregulationofsproutingangiogenesis
MAb 44B1 light chain
2.1
88
80
A0A0E4B213A0A0E4B213A0A0E4B213A0A0E4B213
Leukocyte immunoglobulin-like receptor subfamily B member 2
2.1
50
85
LIRB2LIRB2Q8N423Q8N423adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwayFcreceptormediatedinhibitorysignalingpathwayheterotypiccell-celladhesionimmuneresponseimmuneresponse-inhibitingcellsurfacereceptorsignalingpathwayinterleukin-10-mediatedsignalingpathwaylearningormemorynegativeregulationofantigenprocessingandpresentationnegativeregulationofcalciumiontransportnegativeregulationofpostsynapticdensityorganizationnegativeregulationofproteinmetabolicprocessnegativeregulationofTcellcostimulationnegativeregulationofTcellproliferationpositiveregulationofinterleukin-6productionpositiveregulationoflong-termsynapticdepressionpositiveregulationofproteindephosphorylationpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofTcelltoleranceinductionpositiveregulationoftoleranceinductionregulationofdendriticcelldifferentiationregulationoflong-termsynapticpotentiationsignaltransduction
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
2.0
nan
91
MGAT2MGAT2Q10469Q10469oligosaccharidebiosyntheticprocessproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineviralproteinprocessing
Triggering receptor expressed on myeloid cells 2
3.0
54
82
TREM2TREM2Q9NZC2Q9NZC2amyloid-betaclearancebycellularcatabolicprocessapoptoticcellclearanceastrocyteactivationcellularresponsetoamyloid-betacellularresponsetoglucosestimuluscellularresponsetohypoxiacellularresponsetolipidcellularresponsetolipoteichoicacidcellularresponsetooxidisedlow-densitylipoproteinparticlestimuluscellularresponsetopeptidoglycancomplement-mediatedsynapsepruningCXCL12-activatedCXCR4signalingpathwaydefenseresponsetoGram-negativebacteriumdendriticcelldifferentiationdendriticspinemaintenancedetectionoflipopolysaccharidedetectionoflipoteichoicaciddetectionofpeptidoglycanexcitatorysynapsepruninghumoralimmuneresponseimportintocelllipidhomeostasismemorymicroglialcellactivationmicroglialcellactivationinvolvedinimmuneresponsemicroglialcellproliferationnegativeregulationofamyloidfibrilformationnegativeregulationofastrocyteactivationnegativeregulationofautophagiccelldeathnegativeregulationofautophagynegativeregulationofcellactivationnegativeregulationofcholesterolstoragenegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffatcellproliferationnegativeregulationofglialcellapoptoticprocessnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-1betaproductionnegativeregulationofmacrophagecolony-stimulatingfactorsignalingpathwaynegativeregulationofneuroinflammatoryresponsenegativeregulationofNLRP3inflammasomecomplexassemblynegativeregulationofp38MAPKcascadenegativeregulationofphosphatidylinositol3-kinasesignalingnegativeregulationofsequesteringoftriglyceridenegativeregulationoftoll-likereceptor2signalingpathwaynegativeregulationoftoll-likereceptor4signalingpathwaynegativeregulationoftumornecrosisfactorproductionosteoclastdifferentiationphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofamyloid-betaclearancepositiveregulationofantigenprocessingandpresentationofpeptideantigenviaMHCclassIIpositiveregulationofATPbiosyntheticprocesspositiveregulationofC-CchemokinereceptorCCR7signalingpathwaypositiveregulationofcalcium-mediatedsignalingpositiveregulationofCAMKK-AMPKsignalingcascadepositiveregulationofCD40signalingpathwaypositiveregulationofchemotaxispositiveregulationofcholesteroleffluxpositiveregulationofcomplementactivationclassicalpathwaypositiveregulationofengulfmentofapoptoticcellpositiveregulationofERK1andERK2cascadepositiveregulationofestablishmentofproteinlocalizationpositiveregulationofgeneexpressionpositiveregulationofhigh-densitylipoproteinparticleclearancepositiveregulationofinterleukin-10productionpositiveregulationofinwardrectifierpotassiumchannelactivitypositiveregulationofkinaseactivitypositiveregulationoflow-densitylipoproteinparticleclearancepositiveregulationofmacrophagefusionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofmitochondrionorganizationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofosteoclastdifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofsynapsepruningpositiveregulationofTORsignalingpyroptosisregulationofcytokineproductioninvolvedininflammatoryresponseregulationofgeneexpressionregulationofhippocampalneuronapoptoticprocessregulationofinnateimmuneresponseregulationofinterleukin-6productionregulationofintracellularsignaltransductionregulationoflipidmetabolicprocessregulationofmacrophageinflammatoryprotein1alphaproductionregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofpeptidyl-tyrosinephosphorylationregulationofplasmamembraneboundedcellprojectionorganizationregulationofrestingmembranepotentialregulationoftoll-likereceptor6signalingpathwayregulationofTORsignalingrespiratoryburstafterphagocytosisresponsetoaxoninjuryresponsetoischemiasocialbehavior
Desmocollin-1
2.0
nan
88
DSC1DSC1Q08554Q08554cell-celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
GDP-fucose protein O-fucosyltransferase 1
2.0
75
83
OFUT1OFUT1Q91ZW2Q91ZW2angiogenesisfucosemetabolicprocessheartdevelopmentnervoussystemdevelopmentNotchsignalingpathwayproteinO-linkedfucosylationproteinO-linkedglycosylationregulationofNotchsignalingpathwaysomitogenesis
Integrin beta-2
2.0
34
88
ITB2ITB2P05107P05107amyloid-betaclearanceapoptoticprocesscelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-cellsignalingcell-matrixadhesioncellularresponsetolow-densitylipoproteinparticlestimulusendodermalcelldifferentiationheterotypiccell-celladhesioninflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmicroglialcellactivationnegativeregulationofdopaminemetabolicprocessneutrophilchemotaxisneutrophilmigrationphagocytosisengulfmentpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptorclusteringreceptorinternalizationreceptor-mediatedendocytosisregulationofcellshaperegulationofpeptidyl-tyrosinephosphorylation
Integrin alpha-4
2.0
57
87
ITA4ITA4P13612P13612axonogenesisinvolvedininnervationBcelldifferentiationcelladhesionmediatedbyintegrincell-celladhesioncell-celladhesioninresponsetoextracellularstimuluscell-celladhesionmediatedbyintegrincell-matrixadhesioncell-matrixadhesioninvolvedinameboidalcellmigrationcellularresponsetoamyloid-betacellularresponsetocytokinestimulusclathrin-dependentextracellularexosomeendocytosisdiapedesisendodermalcelldifferentiationheterotypiccell-celladhesionimportintocellintegrin-mediatedsignalingpathwayleukocytecell-celladhesionleukocytemigrationleukocytetetheringorrollingnegativeregulationofproteinhomodimerizationactivityneuronprojectionextensionpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofleukocytetetheringorrollingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialcellproliferationreceptorclusteringsubstrateadhesion-dependentcellspreading
ADP-ribosylation factor-binding protein GGA1
2.0
80
82
GGA1GGA1Q9UJY5Q9UJY5GolgitoplasmamembraneproteintransportGolgitoplasmamembranetransportintracellularproteintransportpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteinlocalizationproteinlocalizationtocellsurfaceproteinlocalizationtociliarymembraneretrogradetransportendosometoGolgitoxintransport
Leucine-rich repeat transmembrane protein FLRT3
2.0
49
89
FLRT3FLRT3Q9NZU0Q9NZU0axonguidancecell-celladhesionviaplasma-membraneadhesionmoleculesembryonicmorphogenesisfibroblastgrowthfactorreceptorsignalingpathwayheaddevelopmentheartdevelopmentneuronprojectiondevelopmentneuronprojectionextensionpositiveregulationofsynapseassemblyproepicardiumcellmigrationinvolvedinpericardiummorphogenesisresponsetoaxoninjurysynapseassemblysynapticmembraneadhesion
Receptor tyrosine-protein kinase erbB-2
2.0
nan
91
ERBB2ERBB2P04626P04626cellsurfacereceptorsignalingpathwaycellularresponsetoepidermalgrowthfactorstimuluscellularresponsetogrowthfactorstimulusenzyme-linkedreceptorproteinsignalingpathwayERBB2-EGFRsignalingpathwayERBB2-ERBB3signalingpathwayERBB2-ERBB4signalingpathwayheartdevelopmentimmatureTcellproliferationinthymusintracellularsignaltransductionmotorneuronaxonguidancemyelinationnegativeregulationofapoptoticprocessnegativeregulationofimmatureTcellproliferationinthymusneurogenesisneuromuscularjunctiondevelopmentneurondifferentiationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneoligodendrocytedifferentiationpeptidyl-tyrosinephosphorylationperipheralnervoussystemdevelopmentphosphatidylinositol3-kinasesignalingpositiveregulationofcelladhesionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofGTPaseactivitypositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofproteinphosphorylationpositiveregulationofproteintargetingtomembranepositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranslationproteinautophosphorylationproteinphosphorylationregulationofangiogenesisregulationofERK1andERK2cascaderegulationofmicrotubule-basedprocesssignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathwaywoundhealing
Metabotropic glutamate receptor 5
2.0
nan
92
GRM5GRM5P41594P41594calcium-mediatedsignalingusingintracellularcalciumsourcecellularresponsetoamyloid-betachemicalsynaptictransmissioncognitiondesensitizationofGprotein-coupledreceptorsignalingpathwayGprotein-coupledglutamatereceptorsignalingpathwaylearninglearningormemorylocomotorybehaviornegativeregulationoflocomotionphospholipaseC-activatingGprotein-coupledglutamatereceptorsignalingpathwaypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationofMAPKcascadepositiveregulationofproteintyrosinekinaseactivityproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofDNA-templatedtranscriptionregulationofintracellularcalciumactivatedchloridechannelactivityregulationofproteinphosphorylationregulationofsynaptictransmissionglutamatergicregulationoftranslationregulationoftranslationalelongationsynapseorganizationtrans-synapticsignalingbyendocannabinoidmodulatingsynaptictransmission
Polypeptide N-acetylgalactosaminyltransferase 1
2.0
60
86
GALT1GALT1O08912O08912proteinO-linkedglycosylationproteinO-linkedglycosylationviaserineproteinO-linkedglycosylationviathreonine
Growth/differentiation factor 8
2.0
53
85
GDF8GDF8O14793O14793cellularresponsetodexamethasonestimulusmusclecellcellularhomeostasismuscleorgandevelopmentmyoblastmigrationinvolvedinskeletalmuscleregenerationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofkinaseactivitynegativeregulationofmusclehypertrophynegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastproliferationnegativeregulationofproteinkinaseBsignalingnegativeregulationofsatellitecelldifferentiationnegativeregulationofskeletalmusclesatellitecellproliferationnegativeregulationofskeletalmuscletissuegrowthovulationcycleprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationoflamellipodiumassemblypositiveregulationofmacrophagechemotaxispositiveregulationofpathway-restrictedSMADproteinphosphorylationresponsetoelectricalstimulusresponsetoestrogenresponsetoethanolresponsetogravityresponsetoheatresponsetomuscleactivityresponsetotestosteroneskeletalmuscleatrophyskeletalmusclesatellitecelldifferentiationSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
MHC class I chain-related protein A
2.0
80
81
H9CTV0H9CTV0H9CTV0H9CTV0
Pro-epidermal growth factor
2.0
48
88
EGFEGFP01133P01133angiogenesisbranchingmorphogenesisofanepithelialtubecerebellargranulecellprecursorproliferationepidermalgrowthfactorreceptorsignalingpathwayepidermalgrowthfactorreceptorsignalingpathwayviaMAPKcascadeepithelialcellproliferationERBB2-EGFRsignalingpathwayERK1andERK2cascademammaryglandalveolusdevelopmentnegativeregulationofcholesteroleffluxnegativeregulationofsecretionpeptidyl-tyrosinephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcerebellargranulecellprecursorproliferationpositiveregulationofDNAbindingpositiveregulationofDNAreplicationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepidermalgrowthfactor-activatedreceptoractivitypositiveregulationofepithelialtubeformationpositiveregulationofgeneexpressionpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofreceptorinternalizationpositiveregulationofubiquitin-dependentproteincatabolicprocessregulationofcalciumionimportregulationofproteinlocalizationtocellsurfaceregulationofreceptorsignalingpathwayviaJAK-STAT
Neurotrimin
2.0
77
84
NTRINTRIQ9P121Q9P121celladhesionneuronrecognition
Dipeptidyl peptidase 1
2.0
44
87
CATCCATCP53634P53634agingimmuneresponsenegativeregulationofmyelinationpositiveregulationofapoptoticsignalingpathwaypositiveregulationofmicroglialcellactivationpositiveregulationofproteolysisinvolvedinproteincatabolicprocessproteolysisproteolysisinvolvedinproteincatabolicprocessresponsetoorganicsubstanceTcellmediatedcytotoxicity
IGL@ protein
2.3
nan
93
Q6N089Q8N5F4Q6N089Q8N5F4
Ribonucleoprotein PTB-binding 1
2.0
63
85
✔
RAVR1RAVR1Q8IY67Q8IY67regulationofalternativemRNAsplicingviaspliceosome
Osteoclast-associated immunoglobulin-like receptor
2.0
88
81
OSCAROSCARQ8IYS5Q8IYS5osteoclastdifferentiation
ER membrane protein complex subunit 1
2.0
55
87
EMC1EMC1Q8N766Q8N766proteininsertionintoERmembranebystop-transfermembrane-anchorsequencetail-anchoredmembraneproteininsertionintoERmembrane
Adhesion G protein-coupled receptor L1
2.0
48
88
AGRL1AGRL1Q80TR1Q80TR1adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycalcium-mediatedsignalingusingintracellularcalciumsourcecellsurfacereceptorsignalingpathwayheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculespositiveregulationofsynapseassemblypositiveregulationofsynapsematuration
Acidic mammalian chitinase
2.0
55
84
CHIACHIAQ9BZP6Q9BZP6apoptoticprocesschitincatabolicprocesschitinmetabolicprocessimmunesystemprocesspolysaccharidecatabolicprocesspolysaccharidedigestionpositiveregulationofchemokineproductionproductionofmolecularmediatorinvolvedininflammatoryresponse
Sodium channel protein type 7 subunit alpha
2.0
62
86
SCN7ASCN7AQ01118Q01118cellularhomeostasismembranedepolarizationduringactionpotentialmusclecontractionneuronalactionpotentialregulationofiontransmembranetransportresponsetobacteriumsodiumionhomeostasissodiumiontransmembranetransportsodiumiontransport
Neuronal acetylcholine receptor subunit alpha-9
2.0
67
84
ACHA9ACHA9Q9UGM1Q9UGM1chemicalsynaptictransmissiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundinnerearmorphogenesisiontransmembranetransportmembranedepolarizationnegativeregulationofERK1andERK2cascadenervoussystemprocesspositiveregulationofcytosoliccalciumionconcentrationregulationofmembranepotentialregulationofnitricoxidemetabolicprocessresponsetoauditorystimulussignaltransduction
Potassium voltage-gated channel subfamily H member 1
2.0
53
87
KCNH1KCNH1Q60603Q60603cellularresponsetocalciumioniontransmembranetransportphosphatidylinositol-mediatedsignalingpotassiumiontransmembranetransportregulationofcellpopulationproliferationregulationofiontransmembranetransportregulationofmembranepotentialregulationofpresynapticcytosoliccalciumionconcentrationregulationofsynapticvesicleexocytosisstartleresponse
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
2.0
41
88
ENPP3ENPP3P97675P97675ATPmetabolicprocessbasophilactivationinvolvedinimmuneresponsenegativeregulationofinflammatoryresponsenegativeregulationofmastcellactivationinvolvedinimmuneresponsenegativeregulationofmastcellproliferationnucleosidetriphosphatecatabolicprocessphosphateionhomeostasisphosphate-containingcompoundmetabolicprocesspyrimidinenucleotidemetabolicprocessregulationofsmoothmusclecelldifferentiation
MHC class I antigen
2.0
79
82
O78189O78189O78189O78189antigenprocessingandpresentationimmuneresponse
Dual oxidase maturation factor 1
2.0
65
83
DOXA1DOXA1Q1HG43Q1HG43hydrogenperoxidemetabolicprocesspositiveregulationofhydrogenperoxidebiosyntheticprocesspositiveregulationofneurondifferentiationproteinlocalizationproteintransportregulationofinflammatoryresponseregulationofthyroidhormonegeneration
Protocadherin gamma subfamily A, 1
2.0
49
86
A0A0A6YW27A0A0A6YW27A0A0A6YW27A0A0A6YW27homophiliccelladhesionviaplasmamembraneadhesionmolecules
Mucosal addressin cell adhesion molecule 1
2.0
64
84
MADCAMADCAQ13477Q13477celladhesioncell-matrixadhesionheterotypiccell-celladhesionimmuneresponseintegrin-mediatedsignalingpathwayleukocytetetheringorrollingpositiveregulationofleukocytemigrationpositiveregulationoflymphocytemigrationreceptorclusteringsignaltransduction
Myelin-associated glycoprotein
2.0
77
84
MAGMAGP20917P20917axonregenerationcelladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescellularresponsetomechanicalstimuluscentralnervoussystemmyelinformationcentralnervoussystemmyelinationmyelinationnegativeregulationofaxonextensionnegativeregulationofneuronapoptoticprocessnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentpositiveregulationofastrocytedifferentiationpositiveregulationofmyelinationtransmissionofnerveimpulse
Cathepsin Z
2.0
32
88
✔
CATZCATZQ9UBR2Q9UBR2angiotensinmaturationepithelialtubebranchinginvolvedinlungmorphogenesisnegativeregulationofplasminogenactivationnegativeregulationofproteinbindingproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofneurondeath
Regenerating islet-derived protein 3-alpha
2.0
55
86
REG3AREG3AQ06141Q06141acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellwalldisruptioninanotherorganismheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesnegativeregulationofkeratinocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofkeratinocyteproliferationpositiveregulationofwoundhealingresponsetopeptidehormone
Interleukin-7
2.0
41
87
IL7IL7P13232P13232animalorganmorphogenesisBcellproliferationboneresorptioncell-cellsignalingcytokine-mediatedsignalingpathwayextrinsicapoptoticsignalingpathwayhomeostasisofnumberofcellswithinatissuehumoralimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofcatalyticactivitynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandorgangrowthpositiveregulationofBcelldifferentiationpositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationoforgangrowthpositiveregulationofTcelldifferentiationregulationofpeptidyl-tyrosinephosphorylationTcelllineagecommitment
Sphingosine 1-phosphate receptor 2
2.0
41
88
S1PR2S1PR2O95136O95136actincytoskeletonreorganizationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayexcitatorypostsynapticpotentialfilopodiumassemblyGprotein-coupledreceptorsignalingpathwaynegativeregulationofexcitatorypostsynapticpotentialnegativeregulationofsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofestablishmentofendothelialbarrierpositiveregulationofpeptidyl-threoninephosphorylationregulationofmetabolicprocesssphingosine-1-phosphatereceptorsignalingpathway
Monotreme lactation protein
2.0
64
84
F6UME2F6UME2A0A088CNJ7A0A088CNJ7
Intercellular adhesion molecule 1
2.0
42
87
ICAM1ICAM1P05362P05362adhesionofsymbionttohostcelladhesioncellularresponsetoamyloid-betaestablishmentofendothelialbarrierheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesleukocytecell-celladhesionleukocytemigrationmembranetomembranedockingnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofcellularextravasationpositiveregulationofERK1andERK2cascadereceptor-mediatedvirionattachmenttohostcellregulationofleukocytemediatedcytotoxicityTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcell
T cell receptor gamma constant 2
2.0
84
80
TRGC2TRGC2P03986P03986adaptiveimmuneresponsegamma-deltaTcellactivationimmuneresponseTcellreceptorsignalingpathway
HLA class I histocompatibility antigen, alpha chain G
2.0
81
83
HLAGHLAGP17693P17693antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofpeptideantigenviaMHCclassIcellulardefenseresponseimmuneresponse-inhibitingcellsurfacereceptorsignalingpathwaynegativeregulationofangiogenesisnegativeregulationofdendriticcelldifferentiationnegativeregulationofG0toG1transitionnegativeregulationofimmuneresponsenegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofproteinkinaseBsignalingnegativeregulationofTcellmediatedcytotoxicitynegativeregulationofTcellproliferationperipheralBcelltoleranceinductionpositiveregulationofcellularsenescencepositiveregulationofendothelialcellapoptoticprocesspositiveregulationofinterleukin-12productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofnaturalkillercellcytokineproductionpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofTcelltoleranceinductionpositiveregulationoftoleranceinductionprotectionfromnaturalkillercellmediatedcytotoxicityproteinhomotrimerization
Tumor necrosis factor ligand superfamily member 4
2.0
61
87
TNFL4TNFL4P43488P43488acuteinflammatoryresponsebloodvesseldevelopmentCD4-positivealpha-betaTcellcostimulationcellularresponsetolipopolysaccharidecellularresponsetonitrogendioxidecellularresponsetoprostaglandinEstimuluscholesterolmetabolicprocessdefenseresponsetonematodeinflammatoryresponseinnateimmuneresponsememoryTcellactivationnegativeregulationofactivation-inducedcelldeathofTcellsnegativeregulationofcytokineproductionnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinterleukin-17productionnegativeregulationofregulatoryTcelldifferentiationnegativeregulationofTcellapoptoticprocessnegativeregulationofT-helper1celldifferentiationnegativeregulationoftypeIIinterferonproductionpositiveregulationofactivatedTcellproliferationpositiveregulationofalpha-betaTcellproliferationpositiveregulationofBcellactivationpositiveregulationofCD4-positivealpha-betaTcellcostimulationpositiveregulationofCD4-positivealpha-betaTcelldifferentiationpositiveregulationofchemokineproductionpositiveregulationofcytokineproductionpositiveregulationofimmuneeffectorprocesspositiveregulationofimmunoglobulinmediatedimmuneresponsepositiveregulationofimmunoglobulinproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofinterleukin-4-dependentisotypeswitchingtoIgEisotypespositiveregulationofinterleukin-6productionpositiveregulationofmemoryTcellactivationpositiveregulationofmemoryTcelldifferentiationpositiveregulationofTcellcostimulationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellactivationpositiveregulationofT-helper2celldifferentiationpositiveregulationoftype2immuneresponsepositiveregulationoftypeIIinterferonproductionregulationofadaptiveimmuneresponseregulationofinflammatoryresponseresponsetonitrogendioxideresponsetovirusTcellproliferationT-helper2cellactivation
Hypocretin neuropeptide precursor
2.0
33
87
OREXOREXO43612O43612chemicalsynaptictransmissioneatingbehaviorexcitatorypostsynapticpotentialnegativeregulationofDNAreplicationnegativeregulationofpotassiumiontransportnegativeregulationoftransmissionofnerveimpulseneuropeptidesignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcalciumiontransportpositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationoftransmissionofnerveimpulseproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofneurotransmittersecretionresponsetostarvationsleeptemperaturehomeostasis
Epidermal growth factor
2.0
51
87
Q6QBS2Q6QBS2Q6QBS2Q6QBS2
Enteropeptidase
2.0
53
88
ENTKENTKP98073P98073proteolysis
Vitamin D-binding protein
2.0
52
86
VTDBVTDBP02774P02774vitaminDmetabolicprocessvitamintransport
Smoothened homolog
2.0
42
87
SMOSMOP56726P56726alpha-tubulinacetylationanterior/posteriorpatternspecificationapoptoticprocessastrocyteactivationatrialseptummorphogenesisaxonextensioninvolvedinaxonguidancecelldevelopmentcellfatespecificationcellpopulationproliferationcellularresponsetocholesterolcentralnervoussystemdevelopmentcentralnervoussystemneurondifferentiationcerebellarcortexmorphogenesiscerebralcortexdevelopmentcommissuralneuronaxonguidancecontactinhibitiondentategyrusdevelopmentdeterminationofleft/rightasymmetryinlateralmesodermdeterminationofleft/rightsymmetrydevelopmentalgrowthdigestivetractdevelopmentdopaminergicneurondifferentiationdorsal/ventralneuraltubepatterningdorsal/ventralpatternformationembryonicorgandevelopmentepithelialcelldifferentiationepithelialcellproliferationepithelial-mesenchymalcellsignalingforebrainmorphogenesishairfollicledevelopmenthairfolliclemorphogenesisheartloopingheartmorphogenesishomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentleft/rightaxisspecificationmammaryglandepithelialcelldifferentiationmesenchymaltoepithelialtransitionmesenchymaltoepithelialtransitioninvolvedinmetanephricrenalvesicleformationmidgutdevelopmentmulticellularorganismgrowthmyoblastmigrationnegativeregulationofapoptoticprocessnegativeregulationofDNAbindingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhairfollicledevelopmentnegativeregulationofhepatocyteproliferationnegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellmigrationneuroblastproliferationodontogenesisofdentin-containingtoothossificationosteoblastdifferentiationpancreasmorphogenesispatternspecificationprocesspositiveregulationofautophagypositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationofhepaticstellatecellactivationpositiveregulationofhhtargettranscriptionfactoractivitypositiveregulationofmesenchymalcellproliferationpositiveregulationofmulticellularorganismgrowthpositiveregulationofneuralprecursorcellproliferationpositiveregulationofneuroblastproliferationpositiveregulationoforgangrowthpositiveregulationofproteinimportintonucleuspositiveregulationofsmoothenedsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularassociatedsmoothmusclecellmigrationproteinimportintonucleusproteinlocalizationtonucleusproteinstabilizationregulationofgeneexpressionregulationofheartmorphogenesisregulationofsomaticstemcellpopulationmaintenanceskeletalmusclefiberdevelopmentsmoothmuscletissuedevelopmentsmoothenedsignalingpathwaysmoothenedsignalingpathwayinvolvedinregulationofcerebellargranulecellprecursorcellproliferationsmoothenedsignalingpathwayinvolvedinventralspinalcordpatterningsomitedevelopmentthalamusdevelopmenttypeBpancreaticcelldevelopmentvasculogenesisventralmidlinedetermination
Complement decay-accelerating factor
2.0
61
88
DAFDAFP08174P08174complementactivationclassicalpathwayinnateimmuneresponsenegativeregulationofcomplementactivationnegativeregulationofcomplementactivationclassicalpathwaypositiveregulationofCD4-positivealpha-betaTcellactivationpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofTcellcytokineproductionregulationofcomplementactivationregulationofcomplement-dependentcytotoxicityregulationoflipopolysaccharide-mediatedsignalingpathwayrespiratoryburstTcellmediatedimmunity
Transmembrane protein 87A
2.0
50
85
TM87ATM87AQ8NBN3Q8NBN3retrogradetransportendosometoGolgi
Properdin
2.0
45
89
PROPPROPP27918P27918complementactivationcomplementactivationalternativepathwaydefenseresponsetobacteriumimmuneresponsepositiveregulationofimmuneresponsepositiveregulationofopsonization
Carboxypeptidase A1
2.0
45
84
CBPA1CBPA1P15085P15085leukotrienemetabolicprocessproteolysisproteolysisinvolvedinproteincatabolicprocessresponsetocadmiumion
Thioredoxin domain-containing protein 5
2.3
46
87
✔
TXND5TXND5Q8NBS9Q8NBS9negativeregulationofapoptoticprocessproteinfolding
Interleukin-21 receptor
2.1
nan
89
IL21RIL21RQ9HBE5Q9HBE5cytokine-mediatedsignalingpathwayimmunoglobulinmediatedimmuneresponsenaturalkillercellactivation
Adhesion G protein-coupled receptor E2
2.0
61
87
AGRE2AGRE2Q9UHX3Q9UHX3adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycelladhesioncellmigrationcellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponseregulationofmastcelldegranulation
MAb 106 heavy chain
2.0
nan
88
A0A0F7R1P3A0A0F7R5U8A0A0F7R1P3A0A0F7R5U8
Programmed cell death 1 ligand 1
2.0
84
80
PD1L1PD1L1Q9NZQ7Q9NZQ7adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharideimmuneresponsenegativeregulationofactivatedTcellproliferationnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofCD8-positivealpha-betaTcellactivationnegativeregulationofinterleukin-10productionnegativeregulationofTcellproliferationnegativeregulationoftumornecrosisfactorsuperfamilycytokineproductionnegativeregulationoftypeIIinterferonproductionpositiveregulationofactivatedCD8-positivealpha-betaTcellapoptoticprocesspositiveregulationofcellmigrationpositiveregulationofinterleukin-10productionpositiveregulationofTcellproliferationpositiveregulationoftoleranceinductiontotumorcellresponsetocytokinesignaltransductionTcellcostimulationtoxintransport
Complement C3
2.0
49
87
CO3CO3P01024P01024amyloid-betaclearancecellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitycomplement-mediatedsynapsepruningfattyacidmetabolicprocessGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseneuronremodelingopsonizationoviductepitheliumdevelopmentpositiveregulationofactivationofmembraneattackcomplexpositiveregulationofangiogenesispositiveregulationofapoptoticcellclearancepositiveregulationofapoptoticprocessinanotherorganismpositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofglucosetransmembranetransportpositiveregulationofimmuneresponsepositiveregulationoflipidstoragepositiveregulationofopsonizationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationofproteinphosphorylationpositiveregulationofreceptor-mediatedendocytosispositiveregulationoftypeIIahypersensitivitypositiveregulationofvascularendothelialgrowthfactorproductionproteolysisregulationofcomplementactivationregulationofcomplementactivationalternativepathwayregulationoftriglyceridebiosyntheticprocessresponsetobacteriumsignaltransductionvertebrateeye-specificpatterning
Inhibin beta A chain
2.0
62
88
INHBAINHBAP08476P08476activinreceptorsignalingpathwaycardiacfibroblastcelldevelopmentcelldifferentiationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetoangiotensincellularresponsetocholesterolcellularresponsetofollicle-stimulatinghormonestimulusdefenseresponseendodermalcelldifferentiationerythrocytedifferentiationextrinsicapoptoticsignalingpathwayeyeliddevelopmentincamera-typeeyeGABAergicneurondifferentiationhairfollicledevelopmenthematopoieticprogenitorcelldifferentiationhemoglobinbiosyntheticprocessmalegonaddevelopmentmesodermalcelldifferentiationmulticellularorganismagingnegativeregulationofBcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofmacrophagedifferentiationnegativeregulationofphosphorylationnegativeregulationoftypeIIinterferonproductionnervoussystemdevelopmentodontogenesisovarianfollicledevelopmentpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationoferythrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofgeneexpressionpositiveregulationofovulationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIprogesteronesecretionregulationoffollicle-stimulatinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulusroofofmouthdevelopmentSMADproteinsignaltransductionstriatalmediumspinyneurondifferentiationtranscriptionbyRNApolymeraseII
Glutamate receptor 4
2.0
37
89
GRIA4GRIA4P19493P19493chemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticiontransmembranetransportmodulationofchemicalsynaptictransmissionnegativeregulationofsmoothmusclecellapoptoticprocesspositiveregulationofsynaptictransmissionglutamatergicregulationofpostsynapticmembranepotentialregulationofsynapsestructureoractivityresponsetofungicide
Glypican-1
2.0
49
84
GPC1GPC1P35052P35052cellmigrationheparansulfateproteoglycancatabolicprocessmyelinassemblynegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofskeletalmusclecelldifferentiationregulationofproteinlocalizationtomembraneSchwanncelldifferentiation
Azurocidin
2.0
66
86
CAP7CAP7P20160P20160antimicrobialhumoralresponsecalcium-mediatedsignalingusingintracellularcalciumsourcecellchemotaxiscellularextravasationdefenseresponsetoGram-negativebacteriumdefenseresponsetovirusglialcellmigrationinductionofpositivechemotaxisinflammatoryresponsemacrophagechemotaxismicroglialcellactivationmonocyteactivationnegativeregulationofapoptoticprocessneutrophil-mediatedkillingofbacteriumpositiveregulationofcelladhesionpositiveregulationoffractalkineproductionpositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofphagocytosispositiveregulationofproteinkinaseactivitypositiveregulationoftumornecrosisfactorproductionproteinkinaseCsignalingproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteolysisregulationofvascularpermeability
Low-density lipoprotein receptor-related protein 6
2.0
59
87
LRP6LRP6O75581O75581canonicalWntsignalingpathwaycanonicalWntsignalingpathwayinvolvedinneuralcrestcelldifferentiationcanonicalWntsignalingpathwayinvolvedinregulationofcellproliferationcell-celladhesioncellularresponsetocholesterolchemicalsynaptictransmissiondopaminergicneurondifferentiationmidbraindopaminergicneurondifferentiationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofsmoothmusclecellapoptoticprocessneuralcrestcelldifferentiationneuralcrestformationpositiveregulationofcellcyclepositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtoplasmamembranereceptor-mediatedendocytosisinvolvedincholesteroltransportresponsetopeptidehormoneWntsignalingpathwayWntsignalingpathwayinvolvedinmidbraindopaminergicneurondifferentiationWntsignalingpathwayinvolvedinsomitogenesis
Acyloxyacyl hydrolase
2.0
44
85
✔
AOAHAOAHP28039P28039fattyacidmetabolicprocesslipopolysaccharidecatabolicprocessnegativeregulationofinflammatoryresponse
Prostaglandin D2 receptor 2
2.0
65
85
PD2R2PD2R2Q9Y5Y4Q9Y5Y4adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycalcium-mediatedsignalingchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponsenegativeregulationofmalegermcellproliferationneuropeptidesignalingpathwaypositiveregulationofGprotein-coupledreceptorsignalingpathway
Vascular endothelial growth factor B
2.0
61
86
VEGFBVEGFBP49765P49765cardiacmusclecontractioncoronaryvasculaturedevelopmentinductionofpositivechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocesspositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofmastcellchemotaxispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofvascularwoundhealingproteinO-linkedglycosylationresponsetohypoxiasproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Ribonuclease T2
2.0
70
87
RNT2RNT2O00584O00584innateimmuneresponseRNAcatabolicprocess
Protocadherin-1
2.0
58
87
PCDH1PCDH1Q08174Q08174celladhesioncell-cellsignalinghomophiliccelladhesionviaplasmamembraneadhesionmoleculesnervoussystemdevelopment
Protocadherin gamma A8
2.0
50
86
Q91XY0Q91XY0Q91XY0Q91XY0homophiliccelladhesionviaplasmamembraneadhesionmolecules
Cytotoxic T-lymphocyte protein 4
2.0
29
91
CTLA4CTLA4P16410P16410adaptiveimmuneresponseBcellreceptorsignalingpathwaycellularresponsetoDNAdamagestimulusimmuneresponsenegativeregulationofBcellproliferationnegativeregulationofimmuneresponsenegativeregulationofregulatoryTcelldifferentiationnegativeregulationofTcellproliferationpositiveregulationofapoptoticprocessTcellreceptorsignalingpathway
Dipeptidyl peptidase 4
2.0
55
86
L5LQ33L5LQ33L5LQ33L5LQ33celladhesionproteolysis
Glutamate receptor
2.0
41
89
G3V9C5G3V9C5G3V9C5G3V9C5calciumiontransmembraneimportintocytosoldirectionallocomotiondopaminemetabolicprocessexcitatorypostsynapticpotentiallong-termsynapticpotentiationmemorynegativeregulationofproteincatabolicprocessneurogenesispositiveregulationofapoptoticprocessproteincatabolicprocessproteinlocalizationtopostsynapticmembraneregulationofneuronalsynapticplasticityresponsetoamphetamineresponsetoethanolresponsetowoundingresponsetoxenobioticstimulussensoryperceptionofpainserotoninmetabolicprocesssleepstartleresponsevisuallearning
Granzyme H
2.0
64
85
GRAHGRAHP20718P20718apoptoticprocesscytolysisproteolysis
Interleukin-13 receptor subunit alpha-1
2.0
44
87
I13R1I13R1P78552P78552cellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwayoncostatin-M-mediatedsignalingpathwaypositiveregulationofcellpopulationproliferation
Acid sphingomyelinase-like phosphodiesterase 3a
2.0
nan
86
ASM3AASM3AQ92484Q92484nucleosidetriphosphatecatabolicprocess
ATP receptor
2.0
70
86
G1M6C4G1M6C4G1M6C4G1M6C4blebassemblycellmorphogenesiscellularresponsetodsRNAcellularresponsetoextracellularstimulusceramidebiosyntheticprocesscollagenmetabolicprocessdefenseresponsetoGram-positivebacteriumextrinsicapoptoticsignalingpathwaygamma-aminobutyricacidsecretionglutamatesecretionhomeostasisofnumberofcellswithinatissueinflammatoryresponseMAPKcascademembraneproteinectodomainproteolysismitochondrialdepolarizationmitochondrionorganizationNADtransportnegativeregulationofboneresorptionnegativeregulationofcellvolumenegativeregulationofMAPKcascadephagolysosomeassemblyphospholipidtransfertomembranephospholipidtranslocationplasmamembraneorganizationporecomplexassemblypositiveregulationofbonemineralizationpositiveregulationofgamma-aminobutyricacidsecretionpositiveregulationofglutamatesecretionpositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofMAPkinaseactivitypositiveregulationofmitochondrialdepolarizationpositiveregulationofprostaglandinsecretionpositiveregulationofproteinsecretionpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicityprostaglandinsecretionproteincatabolicprocessproteinphosphorylationproteinprocessingproteinsecretionreactiveoxygenspeciesmetabolicprocessreleaseofsequesteredcalciumionintocytosolresponsetoATPresponsetocalciumionresponsetoelectricalstimulusresponsetofluidshearstressresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetoxenobioticstimulusresponsetozincionsensoryperceptionofpainskeletalsystemmorphogenesissynapticvesicleexocytosisTcellapoptoticprocessTcellhomeostasisTcellmediatedcytotoxicityTcellproliferationvesiclebuddingfrommembrane
Frizzled-7
2.0
nan
88
FZD7FZD7O75084O75084canonicalWntsignalingpathwaycellularresponsetoretinoicacidmesenchymaltoepithelialtransitionnegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofcell-substrateadhesionnegativeregulationofectodermalcellfatespecificationneurondifferentiationnon-canonicalWntsignalingpathwayviaJNKcascadepositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationinvolvedinwoundhealingpositiveregulationofJNKcascadepositiveregulationofphosphorylationregulationofcanonicalWntsignalingpathwayregulationofDNA-templatedtranscriptionskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationsomaticstemcelldivisionstemcellpopulationmaintenancesubstrateadhesion-dependentcellspreadingTcelldifferentiationinthymusWntsignalingpathwayplanarcellpolaritypathway
Beta-nerve growth factor
2.0
79
81
NGFNGFP01138P01138activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmemorymodulationofchemicalsynaptictransmissionnegativeregulationofcellpopulationproliferationnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidaseactivitynervedevelopmentnervegrowthfactorsignalingpathwayneuronapoptoticprocessneuronprojectionmorphogenesisperipheralnervoussystemdevelopmentpositiveregulationofcollateralsproutingpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofRasproteinsignaltransductionregulationofneurondifferentiationtransmembranereceptorproteintyrosinekinasesignalingpathway
Tumor necrosis factor receptor superfamily member 1B
2.0
nan
93
TNR1BTNR1BP20333P20333agingaorticvalvedevelopmentcellularresponsetogrowthfactorstimuluscellularresponsetolipopolysaccharideextrinsicapoptoticsignalingpathwayglialcell-neuronsignalingimmuneresponseinflammatoryresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofcardiacmusclehypertrophynegativeregulationofcelldeathnegativeregulationofextracellularmatrixconstituentsecretionnegativeregulationofneuroinflammatoryresponsenegativeregulationofneurondeathpositiveregulationofapoptoticprocessinvolvedinmorphogenesispositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmyelinationpositiveregulationofoligodendrocytedifferentiationpulmonaryvalvedevelopmentregulationofcytokineproductioninvolvedinimmuneresponseregulationofmyelinationregulationofneuroinflammatoryresponseregulationofRNAbiosyntheticprocessregulationofTcellcytokineproductionregulationofTcellproliferationRNAdestabilizationtumornecrosisfactor-mediatedsignalingpathway
E-selectin
2.0
57
88
LYAM2LYAM2P16581P16581actinfilament-basedprocessactivationofphospholipaseCactivitycalcium-mediatedsignalingheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinflammatoryresponseleukocytecell-celladhesionleukocytemigrationinvolvedininflammatoryresponseleukocytetetheringorrollingpositiveregulationofleukocytemigrationpositiveregulationofleukocytetetheringorrollingpositiveregulationofreceptorinternalizationregulationofinflammatoryresponseresponsetocytokineresponsetointerleukin-1responsetolipopolysaccharideresponsetotumornecrosisfactor
Stromal cell-derived factor 1
2.0
54
85
SDF1SDF1Q6ICW0Q6ICW0adultlocomotorybehavioranimalorganregenerationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideaxonguidancebloodcirculationcelladhesioncellchemotaxiscellularcalciumionhomeostasiscellularresponsetochemokinechemokine(C-X-Cmotif)ligand12signalingpathwaychemokine-mediatedsignalingpathwaychemotaxisdefenseresponsedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayimmuneresponseinductionofpositivechemotaxisintegrinactivationkillingofcellsofanotherorganismnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofleukocytetetheringorrollingneuronmigrationpositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcalciumionimportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdopaminesecretionpositiveregulationofendothelialcellproliferationpositiveregulationofmonocytechemotaxispositiveregulationofneurondifferentiationpositiveregulationofTcellmigrationregulationofactinpolymerizationordepolymerizationresponsetoheatresponsetohypoxiaresponsetopeptidehormoneresponsetoradiationresponsetoultrasoundresponsetovirussignaltransductionTcellchemotaxistelencephaloncellmigration
Leucine-rich repeat-containing G-protein coupled receptor 5
2.0
51
88
LGR5LGR5O75473O75473epithelialcellproliferationinvolvedinrenaltubulemorphogenesisGprotein-coupledreceptorsignalingpathwayhairfollicledevelopmentinnereardevelopmentoocytedifferentiationpositiveregulationofcanonicalWntsignalingpathwayregulationofcellpopulationproliferation
Leukocyte immunoglobulin-like receptor subfamily B member 1
2.0
50
86
A0A0G2JQ44A0A0G2JQ44A0A0G2JQ44A0A0G2JQ44
Interleukin-27 receptor subunit alpha
2.0
71
84
I27RAI27RAQ6UWB1Q6UWB1cellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoGram-positivebacteriumimmuneresponsenegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-6productionnegativeregulationofneuronapoptoticprocessnegativeregulationofTcellextravasationnegativeregulationofT-helper17typeimmuneresponsenegativeregulationoftumornecrosisfactorproductionnegativeregulationoftype2immuneresponsepositiveregulationofactivatedTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationoftypeIIinterferonproductionregulationofisotypeswitchingtoIgGisotypes
Leukocyte immunoglobulin-like receptor subfamily B member 4
2.0
54
85
LIRB4LIRB4Q8NHJ6Q8NHJ6adaptiveimmuneresponseFcreceptormediatedinhibitorysignalingpathwayinterleukin-10-mediatedsignalingpathwaynegativeregulationofactivatedTcellproliferationnegativeregulationofchemokineproductionnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofcytotoxicTcelldifferentiationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-2productionnegativeregulationofinterleukin-5productionnegativeregulationofinterleukin-6productionnegativeregulationofIP-10productionnegativeregulationofMAPKcascadenegativeregulationofmiRNAtranscriptionnegativeregulationofmonocyteactivationnegativeregulationofosteoclastdifferentiationnegativeregulationofproteinlocalizationtonucleusnegativeregulationofproteintyrosinekinaseactivitynegativeregulationofsignalingreceptoractivitynegativeregulationofTcellcostimulationnegativeregulationofTcellcytokineproductionnegativeregulationofTcellproliferationnegativeregulationofTcellreceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionpositiveregulationofCD8-positivealpha-betaTcelldifferentiationpositiveregulationofregulatoryTcelldifferentiationpositiveregulationofTcellanergyreceptorinternalizationtoleranceinduction
Major histocompatibility complex class I
2.0
77
83
Q9GJ77Q9GJ77Q9GJ77Q9GJ77antigenprocessingandpresentationimmuneresponse
Complement C4-A
2.0
52
87
CO4ACO4AP0C0L4P0C0L4complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonization
MHC class I antigen
2.0
79
82
A0A0F6N4T3A0A0F6N4T3A0A0F6N4T3A0A0F6N4T3antigenprocessingandpresentationimmuneresponse
Protein sidekick-2
2.0
80
82
SDK2SDK2Q6V4S5Q6V4S5camera-typeeyephotoreceptorcelldifferentiationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesretinalayerformationsynapseassembly
D(3) dopamine receptor
2.0
30
92
DRD3DRD3P35462P35462acidsecretionadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-activatingdopaminereceptorsignalingpathwayadenylatecyclase-inhibitingdopaminereceptorsignalingpathwayarachidonicacidsecretionautophagybehavioralresponsetococainecellularcalciumionhomeostasiscircadianregulationofgeneexpressiondopaminemetabolicprocessGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwaygastricemptyinglearninglearningormemorylocomotorybehaviormusculoskeletalmovementspinalreflexactionnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticprocessnegativeregulationofbloodpressurenegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofoligodendrocytedifferentiationnegativeregulationofproteinkinaseBsignalingnegativeregulationofproteinsecretionnegativeregulationofsodiumnegativeregulationofsynaptictransmissionglutamatergicnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvoltage-gatedcalciumchannelactivityphospholipaseC-activatingdopaminereceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytokinesispositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofdopaminereceptorsignalingpathwaypositiveregulationofmitoticnucleardivisionpositiveregulationofrenalsodiumexcretionpositiveregulationoftranscriptionbyRNApolymeraseIIprepulseinhibitionregulationofcircadiansleep/wakecyclesleepregulationofdopaminesecretionregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationoflocomotioninvolvedinlocomotorybehaviorregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofpotassiumiontransportresponsetococaineresponsetohistamineresponsetomorphineresponsetoxenobioticstimulussocialbehaviorvisuallearning
HLA class I histocompatibility antigen B alpha chain
2.0
81
83
Q2L6G2Q2L6G2Q2L6G2Q2L6G2antigenprocessingandpresentationimmuneresponse
Glutamate receptor ionotropic, kainate 5
2.0
47
87
GRIK5GRIK5Q63273Q63273cellularresponsetoglucosestimuluschemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticestablishmentoflocalizationincellexcitatorypostsynapticpotentialiontransmembranetransportmodulationofchemicalsynaptictransmissionpositiveregulationofneuronapoptoticprocessproteinretentioninERlumenreceptorclusteringregulationofmembranepotentialregulationofpostsynapticmembranepotentialregulationofsynapticvesiclefusiontopresynapticactivezonemembranesynaptictransmissionglutamatergic
Cytokine receptor common subunit beta
2.0
50
89
IL3RBIL3RBP32927P32927cellularresponsetointerleukin-3cytokine-mediatedsignalingpathwaygranulocyte-macrophagecolony-stimulatingfactorsignalingpathwayimmunoglobulinmediatedimmuneresponseinterleukin-3-mediatedsignalingpathwayinterleukin-5-mediatedsignalingpathwaypositiveregulationofleukocyteproliferationproteinphosphorylationreceptorsignalingpathwayviaJAK-STATrespiratorygaseousexchangebyrespiratorysystemresponsetolipopolysaccharidesignaltransduction
Igh protein
2.0
49
86
Q99M22Q99M22Q99M22Q99M22
Trefoil factor 1
2.0
26
90
TFF1TFF1P04155P04155carbohydratemetabolicprocesscelldifferentiationcellpopulationproliferationmaintenanceofgastrointestinalepitheliumnegativeregulationofcellpopulationproliferationresponsetoimmobilizationstressresponsetoironionresponsetopeptidehormone
Muscarinic acetylcholine receptor M2
2.0
62
85
ACM2ACM2P08172P08172adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernervoussystemdevelopmentphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwaypresynapticmodulationofchemicalsynaptictransmissionregulationofheartcontractionregulationofsmoothmusclecontractionresponsetovirus
Cubilin
2.0
nan
89
CUBNCUBNO60494O60494cholesterolmetabolicprocesscobalaminmetabolicprocesscobalamintransportestablishmentoflocalizationincelllipoproteintransportreceptor-mediatedendocytosisresponsetobacteriumtissuehomeostasis
Protocadherin-10
2.0
51
87
PCD10PCD10Q9P2E7Q9P2E7celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnervoussystemdevelopment
Protocadherin gamma-B3
2.0
51
86
PCDGFPCDGFQ9Y5G1Q9Y5G1celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnervoussystemdevelopment
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
2.0
42
86
PMGT1PMGT1Q8WZA1Q8WZA1O-glycanprocessingproteinO-linkedglycosylation
Sodium-dependent lysophosphatidylcholine symporter 1
2.0
49
85
NLS1NLS1Q8NA29Q8NA29braindevelopmentcarbohydratetransportcellularresponsetostarvationcognitionenergyhomeostasisestablishmentofblood-brainbarrierfattyacidtransporthippocampusdevelopmentlipidtransportacrossblood-brainbarrierlong-chainfattyacidtransportlysophospholipidtranslocationlysophospholipidtransportmaintenanceofblood-brainbarriermotorbehaviornegativeregulationoffattyacidbeta-oxidationorganicsubstancetransportphosphatidylcholinebiosyntheticprocessphotoreceptorcellmorphogenesisphotoreceptorcelloutersegmentorganizationpositiveregulationofcellgrowthpositiveregulationoftriglyceridebiosyntheticprocessregulationofdendritedevelopmentregulationofmulticellularorganismgrowthregulationofneuronprojectionarborizationregulationofphosphatidylcholinemetabolicprocessregulationofphosphatidylethanolaminemetabolicprocessregulationofphosphatidylserinemetabolicprocessretinamorphogenesisincamera-typeeyeretinalpigmentepitheliumdevelopmenttranscytosistransportacrossblood-brainbarriervery-low-densitylipoproteinparticleassembly
T-cell surface glycoprotein CD1b
2.0
53
86
CD1BCD1BP29016P29016adaptiveimmuneresponseantigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbpositiveregulationofTcellmediatedcytotoxicity
MHC class II HLA-DQ-alpha chain
2.0
79
79
Q30069Q30069Q30069Q30069adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Ectonucleotide pyrophosphatase/phosphodiesterase 1
2.0
nan
90
G3X9S2G3X9S2G3X9S2G3X9S2immuneresponsenitrogencompoundmetabolicprocessorganicsubstancemetabolicprocessprimarymetabolicprocess
Sodium- and chloride-dependent GABA transporter 1
2.0
58
86
SC6A1SC6A1P30531P30531associativelearningchemicalsynaptictransmissionchloridetransmembranetransportgamma-aminobutyricacidimportgamma-aminobutyricacidreuptakeinorganicanionimportacrossplasmamembranememorynegativeregulationofsynaptictransmissionGABAergicpositiveregulationofgamma-aminobutyricacidsecretionresponsetocalciumionresponsetococaineresponsetoestradiolresponsetoinorganicsubstanceresponsetoleadionresponsetopurine-containingcompoundresponsetosucroseresponsetotoxicsubstancesodiumionimportacrossplasmamembranesodiumiontransmembranetransportsynapseorganizationtransportacrossblood-brainbarrier
Folate receptor beta
2.0
48
86
FOLR2FOLR2P14207P14207celladhesionfolicacidtransportfusionofspermtoeggplasmamembraneinvolvedinsinglefertilizationinflammatoryresponsepositiveregulationofcellpopulationproliferationsperm-eggrecognition
C-C motif chemokine 7
2.0
73
81
CCL7CCL7P80098P80098cell-cellsignalingcellularcalciumionhomeostasiscellularresponsetoethanolcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellchemotaxisregulationofcellshaperesponsetogammaradiationsignaltransduction
Neurturin
2.0
65
86
NRTNNRTNQ99748Q99748MAPKcascadenervedevelopmentnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Ribonuclease pancreatic
2.0
56
87
RNAS1RNAS1P07998P07998defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Muscarinic acetylcholine receptor M5
2.0
64
85
ACM5ACM5P08912P08912adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwaychemicalsynaptictransmissiondopaminetransportGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengergastricacidsecretionregulationofphosphatidylinositoldephosphorylationtransmissionofnerveimpulse
Galanin receptor type 1
2.0
74
82
GALR1GALR1P47211P47211adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaynegativeregulationofadenylatecyclaseactivityneuropeptidesignalingpathwaypositiveregulationofcortisolsecretionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationoftranscriptionbyRNApolymeraseII
Protein ADM2
2.0
65
86
ADM2ADM2Q7Z4H4Q7Z4H4adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayangiogenesisdigestionfeedingbehaviornegativeregulationofbloodpressurepositiveregulationofangiogenesispositiveregulationofgeneexpressionpositiveregulationofheartrateproteinphosphorylationregulationofsystemicarterialbloodpressure
Toll-like receptor 3
2.0
55
86
TLR3TLR3O15455O15455activationofNF-kappaB-inducingkinaseactivitycellularresponsetoexogenousdsRNAcellularresponsetointerferon-betacellularresponsetomechanicalstimuluscellularresponsetotypeIIinterferoncellularresponsetoviruscellularresponsetoxenobioticstimulusdefenseresponsetobacteriumdefenseresponsetovirusdetectionofvirusextrinsicapoptoticsignalingpathwayhyperosmoticresponseI-kappaBphosphorylationinnateimmuneresponseJNKcascademalegonaddevelopmentmicroglialcellactivationnecroptoticsignalingpathwaynegativeregulationofosteoclastdifferentiationpositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofchemokineproductionpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftoll-likereceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationoftypeIIIinterferonproductionregulationofdendriticcellcytokineproductionresponsetodsRNAresponsetoexogenousdsRNAsignaltransductiontoll-likereceptorsignalingpathwaytypeIIIinterferonproduction
ALK tyrosine kinase receptor
2.0
49
88
ALKALKQ9UM73Q9UM73adultbehaviorenergyhomeostasishippocampusdevelopmentnegativeregulationoflipidcatabolicprocessneurondevelopmentpeptidyl-tyrosineautophosphorylationphosphorylationpositiveregulationofdendritedevelopmentpositiveregulationofkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivityproteinautophosphorylationregulationofapoptoticprocessregulationofcellpopulationproliferationregulationofdopaminereceptorsignalingpathwayregulationofneurondifferentiationresponsetoenvironmentalenrichmentsignaltransductionswimmingbehaviortransmembranereceptorproteintyrosinekinasesignalingpathway
TRB protein
2.0
84
81
A0A0C4ZKA8A0A0C4ZKA8A0A0C4ZKA8A0A0C4ZKA8
Epigen
2.0
nan
89
EPGNEPGNQ6UW88Q6UW88angiogenesisepidermalgrowthfactorreceptorsignalingpathwayMAPKcascadepositiveregulationofcellpopulationproliferationpositiveregulationofepidermalgrowthfactor-activatedreceptoractivitypositiveregulationofepithelialcellproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivision
Pcdhb8 protein
2.0
52
85
A8E4K6A8E4K6A8E4K6A8E4K6homophiliccelladhesionviaplasmamembraneadhesionmolecules
Integrin alpha-M
2.0
44
86
ITAMITAMP11215P11215amyloid-betaclearanceapoptoticsignalingpathwaycelladhesioncelladhesionmediatedbyintegrincellsurfacereceptorsignalingpathwayinvolvedincell-cellsignalingcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescell-matrixadhesioncomplement-mediatedsynapsepruningectodermalcelldifferentiationforebraindevelopmentinnateimmuneresponseintegrin-mediatedsignalingpathwaymicroglialcellactivationnegativeregulationofdopaminemetabolicprocessphagocytosisengulfmentpositiveregulationofhippocampalneuronapoptoticprocesspositiveregulationofmicroglialcellmediatedcytotoxicitypositiveregulationofneurondeathpositiveregulationofneutrophildegranulationpositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsuperoxideaniongenerationreceptor-mediatedendocytosisvertebrateeye-specificpatterning
Integrin beta-8
2.0
nan
94
ITB8ITB8P26012P26012cartilagedevelopmentcelladhesioncelladhesionmediatedbyintegrincellmigrationcell-matrixadhesiongangliosidemetabolicprocesshardpalatedevelopmentimmuneresponseintegrin-mediatedsignalingpathwayLangerhanscelldifferentiationnegativeregulationofgeneexpressionplacentabloodvesseldevelopmentpositiveregulationofangiogenesispositiveregulationofgeneexpressionregulationoftransforminggrowthfactorbetaactivationresponsetovirustransforminggrowthfactorbetareceptorsignalingpathwayvasculogenesis
Protocadherin gamma B4
2.0
50
86
Q91XX6Q91XX6Q91XX6Q91XX6celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
TP53-binding protein 1
2.0
64
87
TP53BTP53BQ12888Q12888cellularresponsetoDNAdamagestimuluscellularresponsetoX-rayDNAdamagecheckpointsignalingdouble-strandbreakrepairvianonhomologousendjoiningnegativeregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofisotypeswitchingpositiveregulationoftranscriptionbyRNApolymeraseIIproteinhomooligomerization
Major prion protein
2.0
60
83
Q072G4Q072G4Q072G4Q072G4proteinhomooligomerization
Gamma-aminobutyric acid type A receptor subunit gamma2
2.0
74
83
A0A2K5TLN2A0A2K5TLN2A0A2K5TLN2A0A2K5TLN2gamma-aminobutyricacidsignalingpathway
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
2.0
nan
89
SIA7BSIA7BQ9UJ37Q9UJ37O-glycanprocessingproteinglycosylationproteinO-linkedglycosylationproteinsialylationviralproteinprocessing
Receptor-type tyrosine-protein phosphatase delta
2.0
78
83
PTPRDPTPRDP23468P23468heterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesmodulationofchemicalsynaptictransmissionnegativeregulationofreceptorsignalingpathwayviaJAK-STATneurondifferentiationphosphate-containingcompoundmetabolicprocesspositiveregulationofdendritemorphogenesispositiveregulationofsynapseassemblypresynapseassemblypresynapticmembraneassemblyproteindephosphorylationregulationofimmuneresponseregulationofpostsynapticdensityassemblysynapticmembraneadhesiontrans-synapticsignalingbytrans-synapticcomplextransmembranereceptorproteintyrosinephosphatasesignalingpathway
Ephrin-B1
2.0
73
84
EFNB1EFNB1P52795P52795axonguidanceembryonicpatternspecificationephrinreceptorsignalingpathwaynervoussystemdevelopmentneuralcrestcellmigrationpositiveregulationofTcellproliferationpresynapseassemblyTcellcostimulationTcellproliferation
IGL@ protein
2.0
81
81
Q6GMW3Q6GMW3Q6GMW3Q6GMW3
Interleukin-17 receptor A
2.0
53
87
I17RAI17RAQ96F46Q96F46cellsurfacereceptorsignalingpathwaydefenseresponsetofungusfibroblastactivationgranulocytechemotaxisinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwaypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-5productionpositiveregulationofinterleukin-6productionproteincatabolicprocessresponsetovirusT-helper17typeimmuneresponse
Platelet-derived growth factor subunit A
2.0
58
87
PDGFAPDGFAP04085P04085actincytoskeletonorganizationangiogenesisanimalorganmorphogenesiscellactivationcellprojectionassemblycell-cellsignalingcellularresponsetotransforminggrowthfactorbetastimulusembryoniclungdevelopmenthairfollicledevelopmentinnereardevelopmentlungalveolusdevelopmentmalegonaddevelopmentnegativechemotaxisnegativeregulationofphosphatidylinositolbiosyntheticprocessnegativeregulationofplateletactivationplatelet-derivedgrowthfactorreceptorsignalingpathwayplatelet-derivedgrowthfactorreceptor-alphasignalingpathwaypositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingregulationofactincytoskeletonorganizationregulationofbranchinginvolvedinsalivaryglandmorphogenesisbyepithelial-mesenchymalsignalingregulationofpeptidyl-tyrosinephosphorylationregulationofsmoothmusclecellmigrationresponsetoestradiolresponsetohypoxiaresponsetoinorganicsubstanceresponsetoretinoicacidresponsetowoundingresponsetoxenobioticstimulusskindevelopmentwoundhealing
Beta-2-microglobulin
2.0
81
79
D2GW37D2GW37D2GW37D2GW37antigenprocessingandpresentationofpeptideantigenviaMHCclassIimmuneresponse
Granzyme A
2.0
54
82
GRAAGRAAP12544P12544apoptoticprocesscytolysiscytotoxicTcellpyroptoticprocessgranzyme-mediatedprogrammedcelldeathsignalingpathwayimmuneresponsenegativeregulationofDNAbindingnegativeregulationofendodeoxyribonucleaseactivitynegativeregulationofoxidoreductaseactivitypositiveregulationofapoptoticprocessproteolysisinvolvedinproteincatabolicprocesspyroptosisresponsetobacterium
Ig-like domain-containing protein
2.0
80
81
F7H602F7H602F7H602F7H602regulationofimmuneresponse
Glucose-dependent insulinotropic receptor
2.0
59
86
GP119GP119Q8TDV5Q8TDV5adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayinsulinsecretionregulationofmetabolicprocess
Activin receptor type-1B
2.0
47
85
ACV1BACV1BP36896P36896activinreceptorsignalingpathwaycellularresponsetogrowthfactorstimulusextrinsicapoptoticsignalingpathwayG1/Stransitionofmitoticcellcyclehairfollicledevelopmentinuteroembryonicdevelopmentnegativeregulationofcellgrowthnegativeregulationofgeneexpressionnervoussystemdevelopmentnodalsignalingpathwaypeptidyl-threoninephosphorylationpositiveregulationofactivinreceptorsignalingpathwaypositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationoftrophoblastcellmigrationproteinautophosphorylationproteinphosphorylationregulationofDNA-templatedtranscriptionsignaltransductiontransmembranereceptorproteinserine/threoninekinasesignalingpathway
MHC class II HLA-DQ-alpha chain
2.0
80
80
Q30066Q30066Q30066Q30066adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
5-hydroxytryptamine receptor 1B
2.1
nan
92
5HT1B5HT1BP28222P28222adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingserotoninreceptorsignalingpathwayboneremodelingcellularresponsetoalkaloidcellularresponsetotemperaturestimuluscellularresponsetoxenobioticstimuluschemicalsynaptictransmissiondrinkingbehaviorGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernegativeregulationofgamma-aminobutyricacidsecretionnegativeregulationofserotoninsecretionnegativeregulationofsynaptictransmissionGABAergicnegativeregulationofsynaptictransmissionglutamatergicpositiveregulationofvascularassociatedsmoothmusclecellproliferationpresynapticmodulationofchemicalsynaptictransmissionproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofbehaviorregulationofdopaminesecretionregulationofsynapticvesicleexocytosisresponsetococaineresponsetoethanolresponsetomineralocorticoidvasoconstriction
Carboxypeptidase B2
2.0
45
82
CBPB2CBPB2Q96IY4Q96IY4bloodcoagulationcellularresponsetoglucosestimulusfibrinolysisliverregenerationnegativeregulationoffibrinolysisnegativeregulationofhepatocyteproliferationnegativeregulationofplasminogenactivationpositiveregulationofextracellularmatrixconstituentsecretionproteincatabolicprocessproteolysisresponsetoheatresponsetoxenobioticstimulus
Sacsin
2.0
26
90
✔
SACSSACSQ9NZJ4Q9NZJ4negativeregulationofinclusionbodyassemblyproteinfolding
Sphingomyelin phosphodiesterase
2.0
42
87
ASMASMQ04519Q04519cellularresponsetocalciumioncellularresponsetoUVceramidebiosyntheticprocessceramidemetabolicprocesscholesterolmetabolicprocessnegativeregulationofMAPkinaseactivityplasmamembranerepairpositiveregulationofapoptoticprocesspositiveregulationofendocytosispositiveregulationofproteindephosphorylationpositiveregulationofviralentryintohostcellresponsetococaineresponsetointerleukin-1responsetoionizingradiationresponsetotumornecrosisfactorresponsetotypeIinterferonresponsetovirusresponsetoxenobioticstimulussphingomyelincatabolicprocessterminationofsignaltransductionviralentryintohostcellwoundhealing
Ephrin-A1
2.0
56
84
EFNA1EFNA1P20827P20827angiogenesisaorticvalvemorphogenesisaxonguidancecellmigrationcell-cellsignalingendocardialcushiontomesenchymaltransitioninvolvedinheartvalveformationephrinreceptorsignalingpathwaymitralvalvemorphogenesisnegativeregulationofdendriticspinemorphogenesisnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofMAPKcascadenegativeregulationofproteolysisinvolvedinproteincatabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInotochordformationpositiveregulationofamyloid-betaformationpositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofMAPKcascadepositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivityproteinstabilizationregulationofangiogenesisregulationofaxonogenesisregulationofbloodvesselendothelialcellmigrationregulationofcelladhesionmediatedbyintegrinregulationofpeptidyl-tyrosinephosphorylationsubstrateadhesion-dependentcellspreading
Angiotensin-converting enzyme
2.0
45
84
A0A7D7FA76A0A7D7FA76A0A7D7FA76A0A7D7FA76proteolysis
Kappa light chain C_region
2.0
92
80
Q65ZC0Q65ZC0Q65ZC0Q65ZC0
BDNF/NT-3 growth factors receptor
2.0
69
79
NTRK2NTRK2Q16620Q16620brain-derivedneurotrophicfactorreceptorsignalingpathwaycellularresponsetoaminoacidstimuluscellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetonervegrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebralcortexdevelopmentcircadianrhythmfeedingbehaviorglutamatesecretionlearninglong-termsynapticpotentiationmechanoreceptordifferentiationmyelinationinperipheralnervoussystemnegativeregulationofamyloid-betaformationnegativeregulationofanoikisnegativeregulationofneuronapoptoticprocessneurondifferentiationneuronmigrationneuronalactionpotentialpropagationoligodendrocytedifferentiationpeptidyl-serinephosphorylationperipheralnervoussystemneurondevelopmentpositiveregulationofaxonogenesispositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationofsynapseassemblyproteinautophosphorylationregulationofGTPaseactivityregulationofproteinkinaseBsignalingretinalrodcelldevelopmenttrans-synapticsignalingbyBDNFmodulatingsynaptictransmissiontrans-synapticsignalingbyneuropeptidemodulatingsynaptictransmissiontransmembranereceptorproteintyrosinekinasesignalingpathwayvasculogenesis
Excision repair cross-complementing rodent repair deficiency, complementation group 6 variant
2.0
49
83
Q59FF6Q59FF6Q59FF6Q59FF6
Plexin-A1
2.0
45
89
✔
PLXA1PLXA1P70206P70206dichotomoussubdivisionofterminalunitsinvolvedinsalivaryglandbranchinggonadotrophin-releasinghormoneneuronalmigrationtothehypothalamusnegativeregulationofcelladhesionneuronprojectionextensionneuronprojectionguidanceolfactorynerveformationpositiveregulationofaxonogenesisregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivityregulationofsmoothmusclecellmigrationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidance
Intercellular adhesion molecule 5
2.0
49
89
ICAM5ICAM5Q9UMF0Q9UMF0celladhesioncell-celladhesionphagocytosisregulationofsynapseassembly
Angiotensinogen
2.0
45
87
ANGTANGTP01019P01019activationofphospholipaseCactivityagingangiotensin-activatedsignalingpathwayangiotensin-mediateddrinkingbehaviorarterysmoothmusclecontractionassociativelearningbloodvesselremodelingcellgrowthinvolvedincardiacmusclecelldevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetoangiotensincellularresponsetomechanicalstimuluscellularsodiumionhomeostasisERK1andERK2cascadefemalepregnancyfibroblastproliferationGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocGMPnucleotidesecondmessengerkidneydevelopmentlow-densitylipoproteinparticleremodelingmaintenanceofbloodvesseldiameterhomeostasisbyrenin-angiotensinnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofendopeptidaseactivitynegativeregulationofgeneexpressionnegativeregulationofMAPkinaseactivitynegativeregulationofneurotrophinTRKreceptorsignalingpathwaynegativeregulationofsodiumiontransmembranetransporteractivitynegativeregulationoftissueremodelingnitricoxidemediatedsignaltransductionoperantconditioningphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofactivationofJanuskinaseactivitypositiveregulationofbloodpressurepositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcardiacmusclehypertrophypositiveregulationofCoA-transferaseactivitypositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellmigrationpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofextracellularmatrixconstituentsecretionpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofgapjunctionassemblypositiveregulationofinflammatoryresponsepositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofL-arginineimportacrossplasmamembranepositiveregulationofL-lysineimportacrossplasmamembranepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmembranehyperpolarizationpositiveregulationofNAD(P)HoxidaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinmetabolicprocesspositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofrenalsodiumexcretionpositiveregulationofsuperoxideaniongenerationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinimportintonucleusregulationofapoptoticprocessregulationofbloodpressureregulationofbloodvolumebyrenin-angiotensinregulationofcalciumiontransportregulationofcardiacconductionregulationofcellgrowthregulationofcellpopulationproliferationregulationofextracellularmatrixassemblyregulationofheartrateregulationoflong-termneuronalsynapticplasticityregulationofnorepinephrinesecretionregulationofrenaloutputbyangiotensinregulationofrenalsodiumexcretionregulationoftransmissionofnerveimpulseregulationofvasoconstrictionrenalsystemprocessrenin-angiotensinregulationofaldosteroneproductionresponsetoestradiolresponsetomuscleactivityinvolvedinregulationofmuscleadaptationsmoothmusclecellproliferationstress-activatedMAPKcascadeuterinesmoothmusclecontractionvasodilation
Interleukin-13 receptor subunit alpha-2
2.0
33
88
I13R2I13R2A8K7E2A8K7E2cytokine-mediatedsignalingpathwayimmunoglobulinmediatedimmuneresponsenegativeregulationofimmunoglobulinproductionnegativeregulationofmastcelldegranulation
C-C motif chemokine 20
2.0
43
87
CCL20CCL20P78556P78556antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingusingintracellularcalciumsourcecellchemotaxiscell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxisdefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofTcellmigrationsignaltransductionTcellmigrationthymocytemigration
HLA class II histocompatibility antigen DQ alpha chain
2.0
81
80
L8E864L8E864Q30063Q30063adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Teneurin-2
2.0
38
88
TEN2TEN2Q9NT68Q9NT68axonguidancecalcium-mediatedsignalingusingintracellularcalciumsourcecell-celladhesionheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesnegativeregulationoftranscriptionbyRNApolymeraseIIneurondevelopmentpositiveregulationoffilopodiumassemblyretrogradetrans-synapticsignalingbytrans-synapticproteincomplexsignaltransduction
Low affinity immunoglobulin gamma Fc region receptor III-B
2.0
80
84
FCG3BFCG3BO75015O75015cellsurfacereceptorsignalingpathwayimmuneresponseregulationofimmuneresponse
Protein tyrosine phosphatase type IVA 1
2.0
65
83
TP4A1TP4A1Q78EG7Q78EG7cellcyclepositiveregulationofcellmigrationproteindephosphorylation
Anti-lox-1 15C4 light chain
2.0
87
80
A0A097PUG4A0A097PUG4A0A097PUG4A0A097PUG4
Type-1 angiotensin II receptor
2.0
47
87
AGTR1AGTR1P30556P30556angiotensin-activatedsignalingpathwaybloodvesseldiametermaintenancecalcium-mediatedsignalingcellchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekidneydevelopmentlow-densitylipoproteinparticleremodelingmaintenanceofbloodvesseldiameterhomeostasisbyrenin-angiotensinphospholipaseC-activatingangiotensin-activatedsignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofCoA-transferaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofinflammatoryresponsepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofNAD(P)HoxidaseactivitypositiveregulationofphospholipaseA2activitypositiveregulationofproteinmetabolicprocesspositiveregulationofreactiveoxygenspeciesmetabolicprocessregulationofcellgrowthregulationofcellpopulationproliferationregulationofinflammatoryresponseregulationofrenalsodiumexcretionregulationofsystemicarterialbloodpressurebyrenin-angiotensinregulationofvasoconstrictionrenin-angiotensinregulationofaldosteroneproductionRhoproteinsignaltransductionviralentryintohostcell
Adhesion G protein-coupled receptor L2
2.0
51
88
AGRL2AGRL2Q8JZZ7Q8JZZ7adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaybraindevelopmentcellsurfacereceptorsignalingpathwaypositiveregulationofsynapseassemblyresponsetobacteriumsynapseorganization
Neuronal growth regulator 1
2.0
75
84
NEGR1NEGR1Q7Z3B1Q7Z3B1braindevelopmentcell-celladhesionfeedingbehaviorlocomotorybehaviorneuronprojectiondevelopmentpositiveregulationofneuronprojectiondevelopmentregulationofsynapseassembly
Uncharacterized protein DKFZp686G11190
2.0
86
79
Q6MZQ6Q6MZQ6Q6MZQ6Q6MZQ6
Neuroligin-1
2.0
42
88
NLGN1NLGN1Q62765Q62765AMPAglutamatereceptorclusteringcalcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescell-celladhesioninvolvedinsynapsematurationcellularresponsetocalciumionchemicalsynaptictransmissioncytoskeletalmatrixorganizationatactivezoneestablishmentofproteinlocalizationexcitatorysynapseassemblyheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeslong-termsynapticpotentiationmaintenanceofsynapsestructuremodulationofchemicalsynaptictransmissionnegativeregulationofdendriticspinemorphogenesisnervoussystemdevelopmentneurexinclusteringinvolvedinpresynapticmembraneassemblyneuroncell-celladhesionneuronprojectionarborizationneuronprojectiondevelopmentneuronprojectionmorphogenesisneuronalionchannelclusteringNMDAglutamatereceptorclusteringpositiveregulationofcircadiansleep/wakecyclewakefulnesspositiveregulationofdendriticspinedevelopmentpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoffilopodiumassemblypositiveregulationofintracellularsignaltransductionpositiveregulationofneuromuscularsynaptictransmissionpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpresynapticactivezoneassemblypositiveregulationofproteinlocalizationtosynapsepositiveregulationofruffleassemblypositiveregulationofsynapseassemblypositiveregulationofsynaptictransmissionGABAergicpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofsynapticvesicleclusteringpositiveregulationofsynapticvesicleendocytosispositiveregulationofsynapticvesicleexocytosispostsynapticdensityprotein95clusteringpostsynapticmembraneassemblypostsynapticspecializationassemblypresynapticmembraneassemblyproteinlocalizationtosynapseproteintargetingreceptorlocalizationtosynapseregulationofAMPAreceptoractivityregulationofneurondifferentiationregulationofNMDAreceptoractivityregulationofpresynapseorganizationregulationofrespiratorygaseousexchangebynervoussystemprocessretrogradetrans-synapticsignalingbytrans-synapticproteincomplexrhythmicprocesssynapseassemblysynapsematurationsynapseorganizationsynapticmembraneadhesionsynapticvesicleclusteringsynapticvesicleendocytosissynapticvesicletargetingsynapticvesicletransportterminalbuttonorganization
Nuclear receptor ROR-gamma
2.0
66
82
RORGRORGP51449P51449adiposetissuedevelopmentcellularresponsetosterolcircadianregulationofgeneexpressionlymphnodedevelopmentnegativeregulationofthymocyteapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseII"Peyerspatchdevelopment"positiveregulationofcircadianrhythmpositiveregulationofDNA-templatedtranscriptionregulationoffatcelldifferentiationregulationofglucosemetabolicprocessregulationofsteroidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIT-helper17celldifferentiationT-helpercelldifferentiationxenobioticmetabolicprocess
Interleukin-11 receptor subunit alpha
2.0
72
84
I11RAI11RAQ14626Q14626cytokine-mediatedsignalingpathwaydevelopmentalprocessheaddevelopmentpositiveregulationofcellpopulationproliferation
Integrin beta-6
2.0
nan
90
ITB6ITB6P18564P18564bonedevelopmentbronchioledevelopmentcelladhesioncelladhesionmediatedbyintegrincellmigrationcellmorphogenesiscell-matrixadhesioncellularresponsetoionizingradiationenamelmineralizationhardpalatedevelopmentimmuneresponseinflammatoryresponseintegrin-mediatedsignalingpathwayLangerhanscelldifferentiationlungalveolusdevelopmentphospholipidhomeostasisregulationoftransforminggrowthfactorbetaactivationresponsetovirusskindevelopmentSMADproteinsignaltransductionsurfactanthomeostasistransforminggrowthfactorbetaproductiontransforminggrowthfactorbetareceptorsignalingpathwaywoundhealing
Gastric inhibitory polypeptide receptor
2.0
62
87
GIPRGIPRP48546P48546activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwaydesensitizationofGprotein-coupledreceptorsignalingpathwayendocrinepancreasdevelopmentgastricinhibitorypeptidesignalingpathwaygenerationofprecursormetabolitesandenergypositiveregulationofcAMP-mediatedsignalingpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofinsulinsecretionregulationofinsulinsecretionresponsetoaxoninjuryresponsetocalciumionresponsetofattyacidresponsetoglucoseresponsetonutrient
MHC class I DLA-88
2.0
78
82
O46882O46882O46882O46882antigenprocessingandpresentationimmuneresponse
Glycosylphosphatidylinositol anchor attachment 1 protein
2.0
64
84
GPAA1GPAA1O43292O43292attachmentofGPIanchortoproteinproteinretentioninERlumenprotein-containingcomplexassembly
Vascular endothelial growth factor receptor 1
2.0
75
82
VGFR1VGFR1P17948P17948angiogenesisbloodvesselmorphogenesiscellmigrationcellularresponsetovascularendothelialgrowthfactorstimulusembryonicmorphogenesishematopoieticprogenitorcelldifferentiationhyaloidvascularplexusregressionmonocytechemotaxisnegativeregulationofvascularendothelialcellproliferationpeptidyl-tyrosinephosphorylationpositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivityproteinautophosphorylationregulationofMAPKcascadetransmembranereceptorproteintyrosinekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorreceptor-1signalingpathway
Vesicle-associated membrane protein-associated protein A
2.0
77
79
VAPAVAPAQ9P0L0Q9P0L0celldeathceramidetransportCOPII-coatedvesiclebuddingendoplasmicreticulumtoGolgivesicle-mediatedtransportmembranefusionnegativeregulationbyhostofviralgenomereplicationneuronprojectiondevelopmentphospholipidtransportpositiveregulationbyhostofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingproteinlocalizationtoendoplasmicreticulumsphingomyelinbiosyntheticprocesssteroltransportviralreleasefromhostcell
Bone morphogenetic protein 10
2.0
69
85
BMP10BMP10O95393O95393activinreceptorsignalingpathwayadultheartdevelopmentatrialcardiacmuscletissuemorphogenesisBMPsignalingpathwaycardiacmusclecellproliferationcelladhesionhearttrabeculaformationkidneydevelopmentnegativeregulationofcardiacmusclehypertrophynegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofendothelialcellmigrationpathway-restrictedSMADproteinphosphorylationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcartilagedevelopmentpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofsarcomereorganizationregulationofcardiacmusclecontractionregulationofcardiacmusclehypertrophyinresponsetostresssarcomereorganizationSMADproteinsignaltransductionventricularcardiacmusclecelldevelopmentventricularcardiacmuscletissuemorphogenesis
Eukaryotic translation initiation factor 3 subunit I
2.0
66
84
EIF3IEIF3IQ5IH81Q5IH81formationofcytoplasmictranslationinitiationcomplextranslationalinitiation
Neuropeptide Y receptor type 1
2.0
49
87
NPY1RNPY1RP25929P25929adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayfeedingbehaviorGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerglucosemetabolicprocesslocomotorybehavioroutflowtractmorphogenesisregulationofbloodpressureregulationofmulticellularorganismgrowthsensoryperceptionofpain
Triggering receptor expressed on myeloid cells 1
2.0
86
80
TREM1TREM1Q9NP99Q9NP99adaptiveimmuneresponsehumoralimmuneresponseinnateimmuneresponseintracellularsignaltransductionneutrophilchemotaxisneutrophil-mediatedkillingofgram-negativebacterium
Interleukin-3 receptor subunit alpha
3.4
nan
87
IL3RAIL3RAP26951P26951cytokine-mediatedsignalingpathway
EGF-like repeat and discoidin I-like domain-containing protein 3
2.0
nan
92
EDIL3EDIL3O43854O43854celladhesionpositiveregulationofcell-substrateadhesion
Integrin beta-7
2.0
nan
89
ITB7ITB7P26010P26010celladhesioncelladhesionmediatedbyintegrincellmigrationcell-matrixadhesioncell-matrixadhesioninvolvedinameboidalcellmigrationheterotypiccell-celladhesionintegrin-mediatedsignalingpathwayleukocytetetheringorrollingreceptorclusteringsubstrateadhesion-dependentcellspreadingTcellmigration
Paired immunoglobulin-like receptor B
2.0
86
81
Q8K4V6Q8K4V6Q8K4V6Q8K4V6
T-cell differentiation antigen CD6
2.0
46
89
CD6CD6P30203P30203acuteinflammatoryresponsetoantigenicstimulusadaptiveimmuneresponseheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesimmunologicalsynapseformationinnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofproteinphosphorylationpositiveregulationofTcellproliferationresponsetolipopolysaccharide
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
2.0
38
85
NDUA2NDUA2O43678O43678aerobicrespirationblastocysthatchingmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesis
Fibroblast growth factor 19
2.0
64
83
FGF19FGF19O95750O95750animalorganmorphogenesisbileacidandbilesalttransportcelldifferentiationfibroblastgrowthfactorreceptorsignalingpathwayheartdevelopmentnegativeregulationofbileacidbiosyntheticprocessnegativeregulationofgeneexpressionnervoussystemdevelopmentneuralcrestcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofJNKcascadepositiveregulationofproteinphosphorylationregulationofcellmigrationresponsetobacteriumresponsetoethanolresponsetoorganiccycliccompound
Pantetheinase
2.0
37
88
VNN1VNN1O95497O95497acuteinflammatoryresponsecell-celladhesionchronicinflammatoryresponseinflammatoryresponseinnateimmuneresponsepantothenatemetabolicprocesspositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofTcelldifferentiationinthymusresponsetooxidativestress
Receptor-type tyrosine-protein phosphatase C
2.0
49
89
PTPRCPTPRCP08575P08575alpha-betaTcellproliferationBcelldifferentiationBcellproliferationBcellreceptorsignalingpathwaybonemarrowdevelopmentcalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclephasetransitioncellsurfacereceptorsignalingpathwaycellularresponsetoextracellularstimulusdefenseresponsetovirusdephosphorylationDN2thymocytedifferentiationextrinsicapoptoticsignalingpathwaygamma-deltaTcelldifferentiationhematopoieticprogenitorcelldifferentiationheterotypiccell-celladhesionleukocytecell-celladhesionMAPKcascadenaturalkillercelldifferentiationnegativeregulationofcelladhesioninvolvedinsubstrate-boundcellmigrationnegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofERK1andERK2cascadenegativeregulationofinterleukin-2productionnegativeregulationofmicroglialcellactivationnegativeregulationofproteinautophosphorylationnegativeregulationofproteinkinaseactivitynegativeregulationofproteintyrosinekinaseactivitynegativeregulationofTcellmediatedcytotoxicitynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationplasmamembraneraftdistributionpositiveregulationofalpha-betaTcellproliferationpositiveregulationofantigenreceptor-mediatedsignalingpathwaypositiveregulationofBcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofFc-gammareceptorsignalingpathwayinvolvedinphagocytosispositiveregulationofgamma-deltaTcelldifferentiationpositiveregulationofhematopoieticstemcellmigrationpositiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-2productionpositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteintyrosinephosphataseactivitypositiveregulationofstemcellproliferationpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationoftumornecrosisfactorproductionpositivethymicTcellselectionproteinautophosphorylationproteindephosphorylationregulationofcellcycleregulationofgeneexpressionregulationofinterleukin-8productionregulationofphagocytosisregulationofproteintyrosinekinaseactivityregulationofreceptorsignalingpathwayviaJAK-STATreleaseofsequesteredcalciumionintocytosolresponsetogammaradiationstemcelldevelopmentTcellactivationTcelldifferentiationTcellreceptorsignalingpathway
Pituitary adenylate cyclase-activating polypeptide type I receptor
3.3
35
87
PACRPACRP41586P41586activationofphospholipaseCactivityadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycAMP-mediatedsignalingcelldifferentiationcellsurfacereceptorsignalingpathwaydevelopmentofprimaryfemalesexualcharacteristicsmulticellularorganismalresponsetostressnegativeregulationofcelldeathpositiveregulationofcalciumiontransportintocytosolpositiveregulationofcAMP-mediatedsignalingpositiveregulationofinositolphosphatebiosyntheticprocesspositiveregulationofsmallGTPasemediatedsignaltransductionresponsetoestradiolresponsetoethanolresponsetoxenobioticstimulusspermatogenesis
Asialoglycoprotein receptor 1
2.0
55
86
ASGR1ASGR1P07306P07306cellularresponsetoextracellularstimulusreceptor-mediatedendocytosis
Integrin alpha-V
2.0
59
88
ITAVITAVP06756P06756angiogenesisapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancecalciumiontransmembranetransportcelladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-matrixadhesioncell-substrateadhesionendodermalcelldifferentiationentryintohostcellbyasymbiont-containingvacuoleERK1andERK2cascadeextrinsicapoptoticsignalingpathwayinabsenceofligandheterotypiccell-celladhesionintegrin-mediatedsignalingpathwaynegativechemotaxisnegativeregulationofentryofbacteriumintohostcellnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofintracellularsignaltransductionpositiveregulationofosteoblastproliferationpositiveregulationofsmallGTPasemediatedsignaltransductionregulationofphagocytosisregulationoftransforminggrowthfactorbetaactivationsubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetaproductionvasculogenesisviralentryintohostcell
MHC class I antigen
2.0
82
82
A0A678ZGP6A0A678ZGP6A0A678ZGP6A0A678ZGP6antigenprocessingandpresentationimmuneresponse
Myogenesis-regulating glycosidase
2.0
58
85
MYORGMYORGQ6NSJ0Q6NSJ0carbohydratemetabolicprocesspositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofproteinkinaseBsignalingskeletalmusclefiberdevelopment
V-type immunoglobulin domain-containing suppressor of T-cell activation
2.0
60
87
VISTAVISTAQ9H7M9Q9H7M9negativeregulationofalpha-betaTcellactivationnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofCD8-positivealpha-betaTcellproliferationnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-17productionnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionpositiveregulationofcellmigrationpositiveregulationofcollagencatabolicprocesspositiveregulationofendopeptidaseactivitypositiveregulationofgeneexpressionpositiveregulationofregulatoryTcelldifferentiationregulationofimmuneresponsezymogenactivation
Hepatocyte growth factor receptor
2.0
45
89
METMETP08581P08581branchingmorphogenesisofanepithelialtubecellmigrationcellsurfacereceptorsignalingpathwayendothelialcellmorphogenesisestablishmentofskinbarrierliverdevelopmentnegativeregulationofautophagynegativeregulationofguanyl-nucleotideexchangefactoractivitynegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofRhoproteinsignaltransductionnegativeregulationofstressfiberassemblynegativeregulationofthrombin-activatedreceptorsignalingpathwaynervoussystemdevelopmentneurondifferentiationpancreasdevelopmentphagocytosispositivechemotaxispositiveregulationofendothelialcellchemotaxispositiveregulationofkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofproteinkinaseBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIsemaphorin-plexinsignalingpathwaysignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Allergen lipocalin Cav p 1 isoform 1
2.0
43
87
A0A484HM70A0A484HM70A0A484HM70A0A484HM70
Glypican-2
2.0
nan
90
GPC2GPC2Q8N158Q8N158cellmigrationneurondifferentiationpositiveregulationofneuronprojectiondevelopmentregulationofproteinlocalizationtomembraneregulationofsignaltransductionsmoothenedsignalingpathway
Dickkopf-related protein 1
2.0
59
87
DKK1DKK1O94907O94907canonicalWntsignalingpathwaycellmorphogenesisinvolvedindifferentiationembryoniclimbmorphogenesisendocardialcushiondevelopmentendodermformationfacemorphogenesisforebraindevelopmenthairfollicledevelopmentheartvalvedevelopmentlearningormemorylimbdevelopmentmesodermformationmotorlearningnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwayinvolvedincardiacmusclecellfatecommitmentnegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofmesodermalcellfatespecificationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofossificationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpresynapseassemblynegativeregulationofproteinbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofWntsignalingpathwaynegativeregulationofWnt-Frizzled-LRP5/6complexassemblypositiveregulationofcelldeathpositiveregulationofgeneexpressionpositiveregulationofheartinductionbynegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofJUNkinaseactivitypositiveregulationofmidbraindopaminergicneurondifferentiationpositiveregulationofneurondeathpositiveregulationoftau-proteinkinaseactivitypositiveregulationofWntsignalingpathwaycalciummodulatingpathwaypositiveregulationofWntsignalingpathwayplanarcellpolaritypathwayregulationofdopaminergicneurondifferentiationregulationofendodermalcellfatespecificationregulationofreceptorinternalizationregulationofsynaptictransmissionglutamatergicresponsetoretinoicacidsynapsepruningWntsignalingpathwayinvolvedinsomitogenesis
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
2.0
58
85
ASPGASPGP20933P20933proteindeglycosylationproteolysis
Non-secretory ribonuclease
2.0
64
87
RNAS2RNAS2P10153P10153chemotaxisdefenseresponsetovirusinnateimmuneresponseinmucosaRNAcatabolicprocessRNAphosphodiesterbondhydrolysis
Cell division control protein 42 homolog
2.0
61
88
CDC42CDC42P60953P60953actincytoskeletonorganizationactinfilamentorganizationadherensjunctionorganizationcardiacconductionsystemdevelopmentcardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesisCdc42proteinsignaltransductioncelljunctionassemblycellularresponsetotypeIIinterferondendriticcellmigrationdendriticspinemorphogenesisembryonichearttubedevelopmentendocytosisendothelinreceptorsignalingpathwayinvolvedinheartprocessestablishmentofepithelialcellapical/basalpolarityestablishmentofGolgilocalizationestablishmentormaintenanceofcellpolarityfilopodiumassemblyGolgiorganizationheartcontractionintegrin-mediatedsignalingpathwaymacrophagedifferentiationmodificationofsynapticstructuremodulationbyhostofviralprocessnegativeregulationofprotein-containingcomplexassemblyneuronfatedeterminationneuropilinsignalingpathwaynuclearmigrationorganelletransportalongmicrotubulephagocytosisengulfmentpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcytokinesispositiveregulationofepithelialcellproliferationinvolvedinlungmorphogenesispositiveregulationoffilopodiumassemblypositiveregulationoflamellipodiumassemblypositiveregulationofMAPKcascadepositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofpinocytosispositiveregulationofpseudopodiumassemblypositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingproteinlocalizationproteinphosphorylationregulationofattachmentofspindlemicrotubulestokinetochoreregulationoffilopodiumassemblyregulationoflamellipodiumassemblyregulationofmitoticnucleardivisionregulationofpostsynapseorganizationregulationofproteinbindingregulationofstressfiberassemblysubstantianigradevelopmentWntsignalingpathwayplanarcellpolaritypathway
Amiloride-sensitive sodium channel subunit alpha
2.0
43
86
SCNNASCNNAP37088P37088cellularresponsetoacidicpHcellularresponsetoaldosteronecellularresponsetoamiloridecellularresponsetovasopressincellularsodiumionhomeostasismulticellularorganismalwaterhomeostasisregulationofbloodpressuresensoryperceptionofsaltytastesensoryperceptionofsourtastesodiumionhomeostasissodiumionimportacrossplasmamembranesodiumiontransmembranetransport
Coiled-coil-helix-coiled-coil-helix domain containing 1
2.0
44
86
Q2HJE8Q2HJE8Q2HJE8Q2HJE8mitochondrialtranslation
Growth/differentiation factor 5
2.0
63
87
GDF5GDF5P43026P43026BMPsignalingpathwaycell-cellsignalingchondroblastdifferentiationchondrocytedifferentiationembryoniclimbmorphogenesisforelimbmorphogenesishindlimbmorphogenesismesenchymalcellapoptoticprocessnegativeregulationofchondrocytedifferentiationnegativeregulationofepithelialcellproliferationnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofneuronapoptoticprocessossificationinvolvedinboneremodelingpositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofneurondifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationregulationofmulticellularorganismgrowthregulationofSMADproteinsignaltransductionresponsetomechanicalstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Adhesion G protein-coupled receptor B3
2.0
22
90
AGRB3AGRB3O60242O60242adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaymaintenanceofsynapsestructuremotorlearningmyoblastfusionnegativeregulationofangiogenesisneuronremodelingpositiveregulationofsynapseassemblyregulationofdendritemorphogenesisregulationofsynapsematurationregulationofsynapsepruning
Noggin
2.0
37
89
NOGGNOGGQ13253Q13253atrialcardiacmuscletissuemorphogenesisaxialmesodermdevelopmentBMPsignalingpathwayinvolvedinheartdevelopmentcartilagedevelopmentcelldifferentiationinhindbraincranialskeletalsystemdevelopmentdorsal/ventralpatternformationembryonicdigitmorphogenesisembryonicskeletaljointmorphogenesisembryonicskeletalsystemdevelopmentendocardialcushionmorphogenesisendodermformationepithelialcellproliferationepithelialtomesenchymaltransitionexplorationbehaviorfacemorphogenesisfibroblastgrowthfactorreceptorsignalingpathwayinvolvedinneuralplateanterior/posteriorpatternformationhearttrabeculamorphogenesisinuteroembryonicdevelopmentlimbdevelopmentlong-termsynapticpotentiationlungmorphogenesismembranousseptummorphogenesismesodermformationmiddleearmorphogenesismotorneuronaxonguidancenegativeregulationofapoptoticsignalingpathwaynegativeregulationofastrocytedifferentiationnegativeregulationofBMPsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcardiacmusclecellproliferationnegativeregulationofcartilagedevelopmentnegativeregulationofcellmigrationnegativeregulationofcytokineactivitynegativeregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationnegativeregulationofgeneexpressionnegativeregulationofosteoblastdifferentiationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuralplatemorphogenesisneuraltubeclosurenotochordmorphogenesisosteoblastdifferentiationoutflowtractmorphogenesispharyngealarcharterymorphogenesispituitaryglanddevelopmentpositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerulusdevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIpresynapticmodulationofchemicalsynaptictransmissionprostaticbudformationregulationoffibroblastgrowthfactorreceptorsignalingpathwayinvolvedinneuralplateanterior/posteriorpatternformationregulationofneuronalsynapticplasticityshort-termsynapticpotentiationskeletalsystemdevelopmentsmoothenedsignalingpathwaysomaticstemcellpopulationmaintenancesomitedevelopmentspinalcorddevelopmentstemcelldifferentiationuretericbudformationventricularcompactmyocardiummorphogenesisventricularseptummorphogenesisvisuallearningwoundhealing
CD226 antigen
2.0
54
85
CD226CD226Q15762Q15762celladhesioncellrecognitionpositiveregulationofFcreceptormediatedstimulatorysignalingpathwaypositiveregulationofimmunoglobulinmediatedimmuneresponsepositiveregulationofmastcellactivationpositiveregulationofnaturalkillercellcytokineproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftypeIIinterferonproductionsignaltransduction
Cannabinoid receptor 1
2.0
46
87
CNR1CNR1P21554P21554adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayagingaxonalfasciculationcannabinoidsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerglucosehomeostasismaternalprocessinvolvedinfemalepregnancymemorynegativeregulationofactionpotentialnegativeregulationofbloodpressurenegativeregulationofdopaminesecretionnegativeregulationoffattyacidbeta-oxidationnegativeregulationofmastcellactivationnegativeregulationofnitric-oxidesynthaseactivitynegativeregulationofserotoninsecretionpositiveregulationofacuteinflammatoryresponsetoantigenicstimuluspositiveregulationofapoptoticprocesspositiveregulationofbloodpressurepositiveregulationoffevergenerationpositiveregulationofneuronprojectiondevelopmentregulationoffeedingbehaviorregulationofinsulinsecretionregulationofmetabolicprocessregulationofpenileerectionregulationofpresynapticcytosoliccalciumionconcentrationregulationofsynaptictransmissionGABAergicregulationofsynaptictransmissionglutamatergicresponsetococaineresponsetoethanolresponsetolipopolysaccharideresponsetomorphineresponsetonicotineresponsetonutrientretrogradetrans-synapticsignalingbyendocannabinoidsensoryperceptionofpainspermatogenesistrans-synapticsignalingbyendocannabinoidmodulatingsynaptictransmission
MHC class I antigen
2.0
80
83
Q95477Q95477Q95477Q95477antigenprocessingandpresentationimmuneresponse
Astrotactin-2
2.0
49
88
ASTN2ASTN2O75129O75129establishmentofbodyhairplanarorientationnegativeregulationofproteinlocalizationtocellsurfaceneuroncell-celladhesionneuronmigrationproteinlocalizationtocellsurfaceproteintransport
Immunoblobulin G1 Fab heavy chain variable region
2.0
81
80
A4F255A4F255A4F255A4F255
Interleukin-5 receptor subunit alpha
2.0
64
87
IL5RAIL5RAQ01344Q01344cytokine-mediatedsignalingpathwayinflammatoryresponsetoantigenicstimuluspositiveregulationofleukocyteproliferationregulationofinterleukin-5productionsignaltransduction
Dual oxidase 1
2.0
55
85
DUOX1DUOX1Q9NRD9Q9NRD9cuticledevelopmentcytokine-mediatedsignalingpathwaydefenseresponsehormonebiosyntheticprocesshydrogenperoxidebiosyntheticprocesshydrogenperoxidecatabolicprocesspositiveregulationofcellmotilitypositiveregulationofwoundhealingresponsetocAMPresponsetooxidativestresssuperoxideaniongenerationthyroidhormonegeneration
Liver-expressed antimicrobial peptide 2
2.0
53
87
LEAP2LEAP2Q969E1Q969E1antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetobacteriumdefenseresponsetofungus
Formylglycine-generating enzyme
2.1
nan
90
SUMF1ARSAQ8NBK3P15289glycosphingolipidmetabolicprocesspost-translationalproteinmodificationproteinoxidationlipidmetabolicprocess
Histamine H1 receptor
2.0
26
88
HRH1HRH1P35367P35367cellularresponsetohistaminechemicalsynaptictransmissioneosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerinflammatoryresponseinositolphosphate-mediatedsignalingmemoryphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofvasoconstrictionregulationofsynapticplasticityregulationofvascularpermeabilityvisuallearning
C-X-C motif chemokine 5
2.0
40
89
CXCL5CXCL5P42830P42830antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaychemotaxisinflammatoryresponseneutrophilchemotaxispositiveregulationofcellpopulationproliferationsignaltransduction
Interleukin-22 receptor subunit alpha-1
2.0
62
85
I22R1I22R1Q9HB22Q9HB22cytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacterium
Piezo-type mechanosensitive ion channel component 2
2.0
45
88
PIEZ2PIEZ2Q8CD54Q8CD54cationtransportcellularresponsetomechanicalstimulusdetectionofmechanicalstimulusdetectionofmechanicalstimulusinvolvedinsensoryperceptionregulationofmembranepotentialresponsetomechanicalstimulus
Gap junction gamma-3 protein
2.0
55
87
CXG3CXG3Q8NFK1Q8NFK1cell-cellsignalingmyelinationsensoryperceptionofsound
C-X-C chemokine receptor type 1
2.0
64
84
CXCR1CXCR1P25024P25024calcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaydendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseneutrophilchemotaxispositiveregulationofcytosoliccalciumionconcentrationreceptorinternalization
Galanin receptor type 2
2.0
76
81
GALR2GALR2O43603O43603adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayfeedingbehaviorgalanin-activatedsignalingpathwayinositolphosphatemetabolicprocesslearningormemorymusclecontractionnegativeregulationofadenylatecyclaseactivityneuronprojectiondevelopmentneuropeptidesignalingpathwayphosphatidylinositolmetabolicprocessphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationoflargeconductancecalcium-activatedpotassiumchannelactivitypositiveregulationoftranscriptionbyRNApolymeraseII
MHC class I antigen
2.0
77
83
B1A9P6B1A9P6B1A9P6B1A9P6antigenprocessingandpresentationimmuneresponse
Immunoglobulin heavy constant gamma 1
2.0
57
86
A0A0A0MS08A0A0A0MS08A0A0A0MS08A0A0A0MS08
C5a anaphylatoxin chemotactic receptor 1
2.0
66
85
C5AR1C5AR1P21730P21730activationofphospholipaseCactivityamyloid-betaclearanceastrocyteactivationcellulardefenseresponsechemotaxiscognitioncomplementcomponentC5asignalingpathwaycomplementreceptormediatedsignalingpathwaydefenseresponsetoGram-positivebacteriumimmuneresponseinflammatoryresponsemicroglialcellactivationmRNAtranscriptionbyRNApolymeraseIIneutrophilchemotaxisphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofmacrophagechemotaxispositiveregulationofneutrophilchemotaxispositiveregulationofvascularendothelialgrowthfactorproductionpresynapseorganizationregulationoftau-proteinkinaseactivityresponsetopeptidoglycansensoryperceptionofchemicalstimulussignaltransduction
Talin-2
2.0
47
85
TLN2TLN2Q9Y4G6Q9Y4G6celladhesioncell-celladhesioncell-celljunctionassembly
Growth/differentiation factor 11
2.0
62
86
GDF11GDF11O95390O95390amacrinecelldifferentiationcamera-typeeyemorphogenesiscellpopulationproliferationmesodermdevelopmentmetanephrosdevelopmentnegativeregulationofamacrinecelldifferentiationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentpositiveregulationofpathway-restrictedSMADproteinphosphorylationroofofmouthdevelopmentskeletalsystemdevelopmentSMADproteinsignaltransductionspinalcordanterior/posteriorpatterningtypeBpancreaticcellmaturationuretericbuddevelopment
ceramidase
2.0
57
86
A8K0B6A8K0B6A8K0B6A8K0B6fattyacidmetabolicprocess
Protocadherin alpha-7
2.0
53
86
PCDA7PCDA7Q91Y13Q91Y13celladhesioncell-cellrecognitionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
Killer cell immunoglobulin-like receptor 3DL1
2.0
92
80
KI3L1KI3L1P43629P43629immuneresponsenaturalkillercellmediatedcytotoxicity
Prostaglandin E synthase 3
2.0
86
75
✔
TEBPTEBPQ15185Q15185chaperonecofactor-dependentproteinrefoldingchaperone-mediatedproteincomplexassemblycyclooxygenasepathwayfibroblastproliferationglucocorticoidreceptorsignalingpathwayglycogenbiosyntheticprocesslungsacculedevelopmentpositiveregulationofphosphorylationpositiveregulationoftelomeraseactivityprostaglandinbiosyntheticprocessproteinfoldingproteinstabilizationsignaltransductionskindevelopmenttelomeraseholoenzymecomplexassemblytelomeremaintenancetelomeremaintenanceviatelomerase
BTB/POZ domain-containing protein KCTD8
2.0
94
77
KCTD8KCTD8Q6ZWB6Q6ZWB6proteinhomooligomerizationregulationofGprotein-coupledreceptorsignalingpathway
Gamma-aminobutyric acid receptor subunit alpha-4
2.0
72
84
GBRA4GBRA4P48169P48169chemicalsynaptictransmissionchloridetransmembranetransportgamma-aminobutyricacidsignalingpathwayiontransmembranetransportnervoussystemprocessregulationofmembranepotentialregulationofpostsynapticmembranepotentialsignaltransductionsynaptictransmissionGABAergic
Glutamate receptor ionotropic, NMDA 2B
2.0
75
83
NMDE2NMDE2Q13224Q13224braindevelopmentcalciumiontransmembraneimportintocytosolcationtransmembranetransportchemicalsynaptictransmissionexcitatorychemicalsynaptictransmissionexcitatorypostsynapticpotentialglutamatereceptorsignalingpathwayionotropicglutamatereceptorsignalingpathwaylearningormemorylong-termsynapticpotentiationnegativeregulationofdendriticspinemaintenancepositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofneurondeathpositiveregulationofsynaptictransmissionglutamatergicproteinheterotetramerizationregulationofcationtransmembranetransportregulationofneuronalsynapticplasticityregulationofsynapticplasticityresponsetoethanol
Disintegrin and metalloproteinase domain-containing protein 33
2.0
70
84
ADA33ADA33Q9BZ11Q9BZ11proteolysis
Insulin
2.0
51
88
A6XGL2A6XGL2A6XGL2A6XGL2glucosemetabolicprocess
Muellerian-inhibiting factor
2.0
64
86
MISMISP03971P03971agingcell-cellsignalinggonadalmesodermdevelopmentLeydigcelldifferentiationMullerianductregressionnegativeregulationofovarianfollicledevelopmentovarianfollicledevelopmentpathway-restrictedSMADproteinphosphorylationpositiveregulationofgeneexpressionpositiveregulationofNF-kappaBtranscriptionfactoractivitypreantralovarianfolliclegrowthresponsetoorganiccycliccompoundresponsetoxenobioticstimulussexdeterminationsexdifferentiationurogenitalsystemdevelopment
MHC class I antigen
2.0
84
82
A0A0F6N4U7A0A0F6N4U7A0A0F6N4U7A0A0F6N4U7antigenprocessingandpresentationimmuneresponse
APOBEC3H
2.0
68
84
B7TQM8B7TQM8B7TQM8B7TQM8
Artemin
2.0
nan
92
ARTNARTNQ5T4W7Q5T4W7axonguidanceinductionofpositivechemotaxislymphocytemigrationintolymphoidorgansneuroblastproliferationperipheralnervoussystemdevelopment"Peyerspatchmorphogenesis"signaltransduction
HLA class II histocompatibility antigen gamma chain
2.0
56
87
HG2AHG2AP04233P04233antigenprocessingandpresentationantigenprocessingandpresentationofendogenousantigenantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIcellpopulationproliferationchaperonecofactor-dependentproteinrefoldingimmunoglobulinmediatedimmuneresponseintracellularproteintransportmacrophagemigrationinhibitoryfactorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofmatureBcellapoptoticprocessnegativeregulationofpeptidesecretionnegativeregulationofTcelldifferentiationnegativeregulationofviralentryintohostcellnegativethymicTcellselectionpositiveregulationofBcellproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofchemokineproductionpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofdendriticcellantigenprocessingandpresentationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofkinaseactivitypositiveregulationofmacrophagecytokineproductionpositiveregulationofmacrophagemigrationinhibitoryfactorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmonocytedifferentiationpositiveregulationofneutrophilchemotaxispositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofprostaglandinbiosyntheticprocesspositiveregulationofproteinphosphorylationpositiveregulationofTcelldifferentiationpositiveregulationoftype2immuneresponsepositiveregulationofviralentryintohostcellpositivethymicTcellselectionprostaglandinbiosyntheticprocessproteinstabilizationproteintrimerizationprotein-containingcomplexassemblyregulationofmacrophageactivationresponsetotypeIIinterferonTcellactivationinvolvedinimmuneresponseTcellselection
Prostaglandin E2 receptor EP2 subtype
2.0
65
84
PE2R2PE2R2P43116P43116adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetoprostaglandinEstimulusGprotein-coupledreceptorsignalingpathwayinflammatoryresponsepositiveregulationofcytosoliccalciumionconcentrationregulationofcellpopulationproliferationresponsetolipopolysaccharideresponsetonematoderesponsetoprogesterone
Cytochrome b-c1 complex subunit Rieske, mitochondrial
3.3
79
81
UCRIUCRIP13272P13272mitochondrialelectrontransportubiquinoltocytochromecmitochondrialrespiratorychaincomplexIIIassembly
Interleukin-4
2.0
nan
94
D4HNR6D4HNR6D4HNR6D4HNR6Bcellactivationimmuneresponse
MHC class I recognition receptor Ly49I
2.0
63
87
Q9JHN9Q9JHN9Q9JHN9Q9JHN9
Coagulation factor XII
2.0
49
88
FA12FA12P00748P00748bloodcoagulationbloodcoagulationintrinsicpathwayFactorXIIactivationfibrinolysisinnateimmuneresponseplasmakallikrein-kinincascadepositiveregulationofbloodcoagulationpositiveregulationoffibrinolysispositiveregulationofplasminogenactivationproteinautoprocessingproteinprocessingproteolysisresponsetomisfoldedproteinzymogenactivation
Tumor necrosis factor receptor superfamily member 18
2.0
38
90
TNR18TNR18Q9Y5U5Q9Y5U5apoptoticprocessnegativeregulationofapoptoticprocesspositiveregulationofcelladhesionpositiveregulationofleukocytemigrationpositiveregulationoftyrosinephosphorylationofSTATproteinsignaltransduction
Follistatin-related protein 3
2.0
47
88
FSTL3FSTL3O95633O95633celldifferentiationhematopoieticprogenitorcelldifferentiationnegativeregulationofactivinreceptorsignalingpathwaynegativeregulationofBMPsignalingpathwaynegativeregulationofosteoclastdifferentiationnegativeregulationoftransmembranereceptorproteinserine/threoninekinasesignalingpathwayossificationpositiveregulationofcell-celladhesionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofBMPsignalingpathwayregulationoftranscriptionbyRNApolymeraseII
IG c1437_light_IGLV1-40_IGLJ1
2.0
91
79
A0A5C2GVU3A0A5C2GVU3A0A5C2GVU3A0A5C2GVU3
Receptor tyrosine-protein kinase erbB-3
2.0
nan
93
ERBB3ERBB3P21860P21860cranialnervedevelopmentendocardialcushiondevelopmentERBB2-ERBB3signalingpathwayextrinsicapoptoticsignalingpathwayinabsenceofligandheartdevelopmentmotorneuronapoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcelladhesionnegativeregulationofmotorneuronapoptoticprocessnegativeregulationofneuronapoptoticprocessnegativeregulationofsecretionnegativeregulationofsignaltransductionneurogenesisneuronapoptoticprocessperipheralnervoussystemdevelopmentphosphatidylinositol3-kinasesignalingpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcardiacmuscletissuedevelopmentpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteintyrosinekinaseactivityproteinphosphorylationregulationofcellpopulationproliferationSchwanncelldifferentiationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathwaywoundhealing
Interleukin-23 receptor
2.0
78
85
IL23RIL23RQ5VWK5Q5VWK5cytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumimmuneresponseinflammatoryresponseinterleukin-23-mediatedsignalingpathwaynegativeregulationofinterleukin-10productionpositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationofmemoryTcelldifferentiationpositiveregulationofnaturalkillercellproliferationpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationoftyrosinephosphorylationofSTATproteinresponsetolipopolysaccharideresponsetotypeIIinterferon
B protein
2.1
72
83
A0A1E1GJG5A0A1E1GJG5A0A1E1GJG5A0A1E1GJG5antigenprocessingandpresentationimmuneresponse
Muscarinic acetylcholine receptor M1
2.0
33
85
ACM1ACM1P11229P11229adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwaychemicalsynaptictransmissioncognitionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernervoussystemdevelopmentneuromuscularsynaptictransmissionphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwaypositiveregulationofintracellularproteintransportpositiveregulationofiontransportpostsynapticmodulationofchemicalsynaptictransmissionproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofglialcellproliferationregulationoflocomotionregulationofpostsynapticmembranepotentialsalivasecretionsignaltransduction
HLA-DMA protein
2.0
78
80
Q6ICR9Q6ICR9Q6ICR9Q6ICR9adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
T-cell surface glycoprotein CD4
2.0
69
87
F6XGD3F6XGD3F6XGD3F6XGD3adaptiveimmuneresponsecalcium-mediatedsignalingcelladhesioncellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimulusdefenseresponsetoGram-negativebacteriumhelperTcellenhancementofadaptiveimmuneresponseinterleukin-15-mediatedsignalingpathwaymacrophagedifferentiationmaintenanceofproteinlocationincellpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmonocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofTcellactivationpositiveregulationofviralentryintohostcellregulationofcalciumiontransportTcellselection
Complement C5
2.0
41
89
CO5CO5P01031P01031cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
Ficolin-3
2.0
nan
88
FCN3FCN3O75636O75636cellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationcomplementactivationlectinpathwaydefenseresponsetovirusnegativeregulationofRNAbiosyntheticprocessnegativeregulationofviralentryintohostcellpositiveregulationofopsonizationproteolysisrecognitionofapoptoticcell
Interleukin-10 receptor subunit alpha
2.0
59
82
I10R1I10R1Q13651Q13651cytokine-mediatedsignalingpathwaynegativeregulationofautophagypositiveregulationofreceptorsignalingpathwayviaJAK-STATregulationofsynapseorganizationresponsetolipopolysaccharideubiquitin-dependentendocytosis
Corticotropin-releasing factor receptor 2
2.0
44
89
CRFR2CRFR2Q60748Q60748actinfilamentorganizationadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycatecholaminebiosyntheticprocesscellsurfacereceptorsignalingpathwayepithelialcelldifferentiationGprotein-coupledreceptorsignalingpathwaygastricmotilitylong-termsynapticpotentiationnegativeregulationofangiogenesisnegativeregulationofcalciumionimportnegativeregulationofdefecationnegativeregulationofepinephrinesecretionnegativeregulationoffeedingbehaviornegativeregulationoffollicle-stimulatinghormonesecretionnegativeregulationofgeneexpressionnegativeregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusnegativeregulationofluteinizinghormonesecretionnegativeregulationofnorepinephrinesecretionpositiveregulationofbloodpressurepositiveregulationofcAMP-mediatedsignalingpositiveregulationofDNAbiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofheartratepositiveregulationofinterleukin-6productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofserotoninsecretionpositiveregulationofstress-activatedMAPKcascadeproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofERK1andERK2cascadesensoryperceptionofpainskeletalmuscletissuegrowth
Serine protease 57
2.0
65
85
PRS57PRS57Q6UWY2Q6UWY2proteolysis
Exocrine gland-secreted peptide 1
2.1
39
84
ESP1ESP1Q3LHH8Q3LHH8positiveregulationoffemalereceptivity
Protocadherin-18
2.0
50
86
PCD18PCD18Q9HCL0Q9HCL0braindevelopmentcelladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
Procollagen C-endopeptidase enhancer 1
2.0
57
88
PCOC1PCOC1Q15113Q15113collagenbiosyntheticprocessproteolysis
Palmitoleoyl-protein carboxylesterase NOTUM
2.0
nan
87
NOTUMNOTUMQ6P988Q6P988bonedevelopmentnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofWntsignalingpathwayproteindepalmitoleylationregulationofbonemineralizationWntsignalingpathway
Follitropin subunit beta
2.0
38
87
FSHBFSHBP01225P01225femalegametegenerationfemalepregnancyfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofboneresorptionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofsteroidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronebiosyntheticprocessregulationofosteoclastdifferentiationregulationofsignalingreceptoractivitySertolicellproliferationspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
Interleukin-12 receptor subunit beta-1
2.0
66
86
I12R1I12R1P42701P42701cellularresponsetotypeIIinterferoncytokine-mediatedsignalingpathwayimmuneresponseinterleukin-12-mediatedsignalingpathwayinterleukin-23-mediatedsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofinterleukin-17productionpositiveregulationofmemoryTcelldifferentiationpositiveregulationofnaturalkillercellproliferationpositiveregulationofNKTcellproliferationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftypeIIinterferonproductionsignaltransduction
IGK@ protein
2.0
nan
94
Q6N095Q6PIL8Q6N095Q6PIL8
Fibroblast growth factor 23
2.0
73
79
FGF23FGF23Q9GZV9Q9GZV9animalorganmorphogenesiscalciumionhomeostasiscelldifferentiationcellularphosphateionhomeostasiscellularresponsetointerleukin-6cellularresponsetoleptinstimuluscellularresponsetoparathyroidhormonestimuluscellularresponsetovitaminDERK1andERK2cascadefibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationofbonemineralizationnegativeregulationofhormonesecretionnegativeregulationofosteoblastdifferentiationphosphateionhomeostasisphosphate-containingcompoundmetabolicprocesspositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofMAPKKKcascadebyfibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofproteinphosphorylationpositiveregulationofvitaminD24-hydroxylaseactivityregulationofcellmigrationregulationofphosphatetransportresponsetomagnesiumionresponsetosodiumphosphatevitaminDcatabolicprocess
Folliculin
3.6
70
86
✔
FLCNFLCNQ8NFG4Q8NFG4cellproliferationinvolvedinkidneydevelopmentcell-celljunctionassemblycellularresponsetoaminoacidstarvationcellularresponsetostarvationenergyhomeostasisepithelialcellproliferationERK1andERK2cascadehemopoiesisinuteroembryonicdevelopmentintrinsicapoptoticsignalingpathwaylysosomelocalizationnegativeregulationofATPbiosyntheticprocessnegativeregulationofbrownfatcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofcellproliferationinvolvedinkidneydevelopmentnegativeregulationofcellularrespirationnegativeregulationofcold-inducedthermogenesisnegativeregulationofepithelialcellproliferationnegativeregulationofERK1andERK2cascadenegativeregulationofgeneexpressionnegativeregulationofglycolyticprocessnegativeregulationofmitochondrialDNAmetabolicprocessnegativeregulationofmitochondrionorganizationnegativeregulationofmuscletissuedevelopmentnegativeregulationofpost-translationalproteinmodificationnegativeregulationofproteinkinaseBsignalingnegativeregulationofproteinlocalizationtonucleusnegativeregulationofRhoproteinsignaltransductionnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationofautophagypositiveregulationofcelladhesionpositiveregulationofGTPaseactivitypositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofproteinphosphorylationpositiveregulationofTORsignalingpositiveregulationofTORC1signalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinkinaseBsignalingregulationofcytokinesisregulationofhistoneacetylationregulationofpro-BcelldifferentiationregulationofproteinphosphorylationregulationofRasproteinsignaltransductionregulationofTORsignalingTORsignalingtransforminggrowthfactorbetareceptorsignalingpathway
Tyrosine-protein phosphatase non-receptor type substrate 1
2.0
83
81
SHPS1SHPS1P78324P78324celladhesioncellmigrationcellularresponsetohydrogenperoxidecellularresponsetointerleukin-1cellularresponsetointerleukin-12cellularresponsetolipopolysaccharidecellularresponsetotypeIIinterferonmonocyteextravasationnegativeregulationofchemokine(C-Cmotif)ligand5productionnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofERK1andERK2cascadenegativeregulationofI-kappaBphosphorylationnegativeregulationofinflammatoryresponsenegativeregulationofinterferon-betaproductionnegativeregulationofinterleukin-6productionnegativeregulationofJNKcascadenegativeregulationofmacrophageinflammatoryprotein1alphaproductionnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofphagocytosisnegativeregulationofproteinphosphorylationnegativeregulationoftumornecrosisfactorproductionpositiveregulationofphagocytosispositiveregulationofTcellactivationregulationofgeneexpressionregulationofinterleukin-1betaproductionregulationofinterleukin-6productionregulationofnitricoxidebiosyntheticprocessregulationoftumornecrosisfactorproductionregulationoftypeIIinterferonproduction
Hepatitis B virus receptor binding protein
2.0
78
81
Q6PYX1Q6PYX1Q6PYX1Q6PYX1
ST14 protein
2.0
80
80
Q8WVC1Q8WVC1Q8WVC1Q8WVC1proteolysis
Repulsive guidance molecule B
2.0
nan
94
RGMBRGMBQ6NW40Q6NW40BMPsignalingpathwaycelladhesionpositiveregulationofDNA-templatedtranscriptionsignaltransduction
MHC class I antigen
2.0
83
80
F6IQZ4F6IQZ4F6IQZ4F6IQZ4
Gamma-aminobutyric acid receptor subunit alpha-1
2.0
77
82
A0A1B0GV38A0A1B0GV38A0A1B0GV38A0A1B0GV38gamma-aminobutyricacidsignalingpathway
Interleukin-2 receptor subunit alpha
2.0
nan
92
IL2RAIL2RAP01589P01589activatedTcellproliferationactivation-inducedcelldeathofTcellsapoptoticprocesscellsurfacereceptorsignalingpathwayimmuneresponseinflammatoryresponseinflammatoryresponsetoantigenicstimulusnegativeregulationofinflammatoryresponsenegativeregulationofTcellproliferationNotchsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofTcelldifferentiationregulationofCD4-positivealpha-betaTcellproliferationregulationofTcellhomeostaticproliferationregulationofTcelltoleranceinduction
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
2.0
75
85
H0VTT5H0VTT5H0VTT5H0VTT5secretionoflysosomalenzymes
Tapasin
2.0
55
87
✔
TPSNTPSNO15533O15533antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIimmuneresponseMHCclassIproteincomplexassemblyMHCclassIbproteincomplexassemblypeptideantigenassemblywithMHCclassIproteincomplexpeptideantigenstabilizationprotein-containingcomplexassemblyregulationofgeneexpressionregulationofimmuneresponseregulationofproteincomplexstabilityretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Parathyroid hormone 2 receptor
2.0
58
87
PTH2RPTH2RP49190P49190adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesis
Microsomal triglyceride transfer protein large subunit
2.0
23
88
MTPMTPP55157P55157cholesterolhomeostasischylomicronassemblycircadianrhythmestablishmentoflocalizationincelllipidmetabolicprocesslipoproteinmetabolicprocesslipoproteintransportlow-densitylipoproteinparticleremodelingphospholipidtransportplasmalipoproteinparticleassemblyproteinlipidationproteinsecretionresponsetocalciumiontriglyceridemetabolicprocesstriglyceridetransportvery-low-densitylipoproteinparticleassembly
Interleukin-9 receptor
2.0
73
84
IL9RIL9RQ01113Q01113cytokine-mediatedsignalingpathwayimmunoglobulinmediatedimmuneresponseregulationofcellpopulationproliferationsignaltransduction
Cystatin-M
2.0
57
88
CYTMCYTMQ15828Q15828anatomicalstructuremorphogenesisepidermisdevelopmentnegativeregulationofpeptidaseactivity
Dipeptidyl peptidase 4
2.0
58
86
DPP4DPP4P27487P27487behavioralfearresponsecelladhesionendothelialcellmigrationglucagonprocessinglocomotoryexplorationbehaviormembranefusionnegativeregulationofextracellularmatrixdisassemblynegativeregulationofneutrophilchemotaxispeptidehormoneprocessingpositiveregulationofcellpopulationproliferationproteolysispsychomotorbehaviorreceptor-mediatedendocytosisofvirusbyhostcellreceptor-mediatedvirionattachmenttohostcellregulationofcell-celladhesionmediatedbyintegrinresponsetohypoxiaTcellactivationTcellcostimulationviralentryintohostcell
Protein PML
3.7
52
85
PMLPMLP29590P29590activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessbranchinginvolvedinmammaryglandductmorphogenesiscellfatecommitmentcellularresponsetointerleukin-4cellularresponsetoleukemiainhibitoryfactorcellularsenescencecircadianregulationofgeneexpressioncommon-partnerSMADproteinphosphorylationDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendoplasmicreticulumcalciumionhomeostasisentrainmentofcircadianclockbyphotoperiodextrinsicapoptoticsignalingpathwayfibroblastmigrationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmaintenanceofproteinlocationinnucleusmyeloidcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofinterleukin-1betaproductionnegativeregulationofmitoticcellcyclenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftranslationinresponsetooxidativestressnegativeregulationofubiquitin-dependentproteincatabolicprocessoncogene-inducedcellsenescencePMLbodyorganizationpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-templatedtranscriptionpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffibroblastproliferationpositiveregulationofhistonedeacetylationpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationtochromosometelomericregionpositiveregulationofsignaltransductionbyp53classmediatorpositiveregulationoftelomeremaintenanceproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinimportintonucleusproteinstabilizationproteinsumoylationproteintargetingprotein-containingcomplexassemblyprotein-containingcomplexlocalizationregulationofcalciumiontransportintocytosolregulationofcelladhesionregulationofcellcycleregulationofcircadianrhythmregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepairresponsetocytokineresponsetogammaradiationresponsetohypoxiaresponsetoUVretinoicacidreceptorsignalingpathwaysuppressionofviralreleasebyhosttransforminggrowthfactorbetareceptorsignalingpathway
HLA class II histocompatibility antigen, DM beta chain
2.0
79
81
DMBDMBP28068P28068adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIMHCclassIIproteincomplexassemblypeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcellpositiveregulationofTcellproliferation
HLA class II histocompatibility antigen, DM alpha chain
2.0
76
81
DMADMAP28067P28067adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
NKG2-A/NKG2-B type II integral membrane protein
2.0
64
85
NKG2ANKG2AP26715P26715adaptiveimmuneresponseCD8-positivegamma-deltaintraepithelialTcelldifferentiationcellsurfacereceptorsignalingpathwayinnateimmuneresponsenaturalkillercellinhibitorysignalingpathwaynegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofTcellmediatedcytotoxicityregulationofnaturalkillercellactivation
Complement C1q subcomponent subunit B
2.0
83
77
C1QBC1QBP02746P02746complementactivationcomplementactivationclassicalpathwayinnateimmuneresponsesynapsepruning
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1
2.0
76
80
HS3SBHS3SBQ9Y662Q9Y662branchinginvolvedinuretericbudmorphogenesisglycosaminoglycanbiosyntheticprocessheparansulfateproteoglycanbiosyntheticprocessheparansulfateproteoglycanbiosyntheticprocessenzymaticmodificationproteinsulfation
Gamma-aminobutyric acid receptor subunit delta
2.0
66
85
GBRDGBRDO14764O14764chemicalsynaptictransmissionchloridetransmembranetransportiontransmembranetransportnervoussystemprocessregulationofmembranepotentialsignaltransduction
Sodium-dependent serotonin transporter
2.0
60
87
SC6A4SC6A4P31645P31645brainmorphogenesiscellularresponsetocGMPcellularresponsetoretinoicacidcircadianrhythmmemorymonoaminetransportnegativeregulationofcerebellargranulecellprecursorproliferationnegativeregulationofneurondifferentiationnegativeregulationoforgangrowthnegativeregulationofsynaptictransmissiondopaminergicneurotransmittertransportpositiveregulationofcellcyclepositiveregulationofgeneexpressionpositiveregulationofserotoninsecretionregulationofthalamussizeresponsetoestradiolresponsetohypoxiaresponsetonutrientresponsetotoxicsubstanceresponsetoxenobioticstimulusserotoninuptakesocialbehaviorsodiumiontransmembranetransportspermejaculationvasoconstriction
HLA class I antigen
2.0
74
83
C1K0Y1C1K0Y1C1K0Y1C1K0Y1antigenprocessingandpresentationimmuneresponse
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
2.0
66
86
CD38CD38P28907P28907apoptoticsignalingpathwayarterysmoothmusclecontractionBcellproliferationBcellreceptorsignalingpathwayfemalepregnancylong-termsynapticdepressionNADmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofboneresorptionnegativeregulationofDNA-templatedtranscriptionnegativeregulationofneuronprojectiondevelopmentpositiveregulationofBcellproliferationpositiveregulationofcellgrowthpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofinsulinsecretionpositiveregulationofvasoconstrictionresponsetoestradiolresponsetohydroperoxideresponsetohypoxiaresponsetointerleukin-1responsetoprogesteroneresponsetoretinoicacidresponsetoxenobioticstimulussignaltransduction
5-hydroxytryptamine receptor 1F
2.0
64
85
5HT1F5HT1FP30939P30939adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingserotoninreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessenger
LY86 protein
2.0
60
84
A4IFT3A4IFT3A4IFT3A4IFT3immuneresponse
MHC class II antigen
2.0
80
79
B8YAC7B8YAC7B8YAC7B8YAC7adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Solute carrier family 15 member 1
2.0
44
86
F6SG69F6SG69F6SG69F6SG69dipeptideimportacrossplasmamembranetransmembranetransport
Fibrinogen beta chain
2.0
68
85
FIBAFIBBP02671P02675adaptiveimmuneresponsebloodcoagulationcommonpathwaybloodcoagulationfibrinclotformationcell-matrixadhesionfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofbloodcoagulationcommonpathwaynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncelladhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulus
Protocadherin-19
2.0
56
86
PCD19PCD19Q8TAB3Q8TAB3celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
Pre T-cell antigen receptor alpha
2.0
91
78
PTCRAPTCRAQ6ISU1Q6ISU1negativeregulationofthymocyteapoptoticprocess
Protein tweety homolog 1
2.0
64
84
TTYH1TTYH1Q9H313Q9H313cell-celladhesioncell-substrateadhesionchloridetransportfilopodiumassemblyiontransmembranetransportironiontransportmitoticcellcycle
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
2.0
59
87
PMGT2PMGT2Q8NAT1Q8NAT1neuronmigrationproteinO-linkedglycosylationproteinO-linkedmannosylation
Receptor activity-modifying protein 2
2.0
45
87
RAMP2RAMP2O60895O60895adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadherensjunctionassemblyadrenomedullinreceptorsignalingpathwayamylinreceptorsignalingpathwayangiogenesisbasementmembraneassemblybicellulartightjunctionassemblycalciumiontransportcellularresponsetohormonestimuluscellularresponsetovascularendothelialgrowthfactorstimulusGprotein-coupledreceptorsignalingpathwayheartdevelopmentintracellularproteintransportnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofvascularpermeabilitypositiveregulationofangiogenesispositiveregulationofgeneexpressionpositiveregulationofvasculogenesisproteinlocalizationtoplasmamembraneproteintransportreceptorinternalizationregulationofbloodpressureregulationofGprotein-coupledreceptorsignalingpathwaysproutingangiogenesisvascularassociatedsmoothmusclecelldevelopmentvasculogenesis
Kallikrein-5
2.0
67
86
KLK5KLK5Q9Y337Q9Y337amelogenesiscornificationepidermisdevelopmentextracellularmatrixdisassemblypositiveregulationofantibacterialpeptideproductionpositiveregulationofGprotein-coupledreceptorsignalingpathwayproteolysis
5-hydroxytryptamine receptor 1D
2.0
28
89
5HT1D5HT1DP28221P28221adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingserotoninreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerintestinesmoothmusclecontractionregulationofbehaviorregulationoflocomotionvasoconstriction
Vascular endothelial growth factor receptor 3
2.0
34
91
VGFR3VGFR3P35916P35916angiogenesisbloodvesselmorphogenesiscellularresponsetovascularendothelialgrowthfactorstimulushematopoieticprogenitorcelldifferentiationlungalveolusdevelopmentlymphvesseldevelopmentlymphangiogenesisnegativeregulationofapoptoticprocesspeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofJNKcascadepositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofproteinkinaseCsignalingpositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorproductionproteinautophosphorylationregulationofbloodvesselremodelingregulationofMAPKcascaderespiratorysystemprocesssproutingangiogenesistransmembranereceptorproteintyrosinekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathwayvasculaturedevelopment
Store-operated calcium entry-associated regulatory factor
2.1
58
87
SARAFSARAFQ96BY9Q96BY9calciumiontransportregulationofstore-operatedcalciumentry
Glycine receptor alpha 1
2.0
63
84
F1RQB7F1RQB7F1RQB7F1RQB7acrosomereactionadultwalkingbehaviorcellularresponsetoaminoacidstimuluscellularresponsetoethanolcellularresponsetozincionchemicalsynaptictransmissionchloridetransmembranetransportinhibitorypostsynapticpotentialiontransmembranetransportmusclecontractionnegativeregulationoftransmissionofnerveimpulsenervoussystemprocessneuromuscularprocesscontrollingpostureneuronalactionpotentialneuropeptidesignalingpathwaypositiveregulationofacrosomereactionregulationofmembranepotentialregulationofrespiratorygaseousexchangebynervoussystemprocessresponsetoaminoacidrightingreflexsignaltransductionstartleresponsesynaptictransmissionglycinergicvisualperception
IGH + IGL c137_light_IGLV2-8_IGLJ2
2.0
92
79
A0A5C2GJG2A0A5C2GJG2A0A5C2GJG2A0A5C2GJG2
Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase
2.1
55
84
SIA8CSIA8CO43173O43173gangliosidebiosyntheticprocessglycoproteinmetabolicprocessglycosphingolipidbiosyntheticprocessN-glycanprocessingoligosaccharidemetabolicprocessproteinglycosylationproteinsialylation
Interleukin-25
2.0
nan
89
IL25IL25Q9H293Q9H293eosinophildifferentiationinflammatoryresponsetoantigenicstimuluspositiveregulationoftranscriptionbyRNApolymeraseIIresponsetofungusresponsetonematode
Cytohesin-3
2.0
77
81
CYH3CYH3O08967O08967establishmentofepithelialcellpolarityGolgivesicletransportpositiveregulationofcelladhesionregulationofARFproteinsignaltransduction
Neuronal acetylcholine receptor subunit beta-4
2.0
66
83
ACHB4ACHB4P30926P30926behavioralresponsetonicotinechemicalsynaptictransmissioniontransmembranetransportiontransportlocomotorybehaviormembranedepolarizationnervoussystemprocessneuronalactionpotentialpositiveregulationoftransmissionofnerveimpulseregulationofmembranepotentialregulationofneurotransmittersecretionregulationofsmoothmusclecontractionsignaltransductionsmoothmusclecontractionsynaptictransmissioninvolvedinmicturitionsynaptictransmissioncholinergic
Kin of IRRE-like protein 1
2.0
81
81
KIRR1KIRR1Q80W68Q80W68cell-celladhesioncell-celljunctionmaintenanceglomerularfiltrationnegativeregulationofproteinphosphorylationpositiveregulationofactinfilamentpolymerizationrenalproteinabsorption
Protein jagged-1
2.0
52
88
JAG1JAG1P78504P78504angiogenesisaortamorphogenesisaorticvalvemorphogenesisbloodvesselremodelingcardiacneuralcrestcelldevelopmentinvolvedinoutflowtractmorphogenesiscardiacrightventriclemorphogenesiscardiacseptummorphogenesiscellfatedeterminationciliarybodymorphogenesisdistaltubuledevelopmentendocardialcushioncelldevelopmentendothelialcelldifferentiationhemopoiesisinhibitionofneuroepithelialcelldifferentiationinnerearauditoryreceptorcelldifferentiationkeratinocytedifferentiationloopofHenledevelopmentmorphogenesisofanepithelialsheetmyoblastdifferentiationnegativeregulationofcellmigrationnegativeregulationofcell-celladhesionnegativeregulationofcell-matrixadhesionnegativeregulationofendothelialcelldifferentiationnegativeregulationoffatcelldifferentiationnegativeregulationofneurondifferentiationnegativeregulationofstemcelldifferentiationnephrondevelopmentnervoussystemdevelopmentneuroendocrinecelldifferentiationneuronalstemcellpopulationmaintenanceNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwaypodocytedevelopmentpositiveregulationofcardiacepithelialtomesenchymaltransitionpositiveregulationofmyeloidcelldifferentiationpositiveregulationofNotchsignalingpathwaypositiveregulationofosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpulmonaryarterymorphogenesispulmonaryvalvemorphogenesisregulationofcellpopulationproliferationregulationofepithelialcellproliferationregulationofreproductiveprocessresponsetomuramyldipeptideTcellmediatedimmunity
C-C motif chemokine 18
2.0
64
85
CCL18CCL18P55774P55774antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellcommunicationcell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitysignaltransduction
LHFPL tetraspan subfamily member 5 protein
2.0
50
84
LHPL5LHPL5Q4KL25Q4KL25auditoryreceptorcellstereociliumorganizationdetectionofmechanicalstimulusinvolvedinsensoryperceptiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundiontransportsensoryperceptionofsound
Angiogenin
2.0
59
87
ANGIANGIP03950P03950actinfilamentpolymerizationactivationofphospholipaseA2activityactivationofphospholipaseCactivityactivationofproteinkinaseBactivityangiogenesisantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellcommunicationcellmigrationdefenseresponsetoGram-positivebacteriumdiacylglycerolbiosyntheticprocesshomeostaticprocessinnateimmuneresponsenegativeregulationofsmoothmusclecellproliferationnegativeregulationoftranslationoocytematurationovarianfollicledevelopmentplacentadevelopmentpositiveregulationofendothelialcellproliferationpositiveregulationofphosphorylationpositiveregulationofproteinsecretionresponsetohormoneresponsetohypoxiaresponsetoyeastrRNAtranscriptiontRNAcatabolicprocess
T-cell surface glycoprotein CD3 gamma chain
2.0
60
83
CD3GCD3GP09693P09693adaptiveimmuneresponsealpha-betaTcellactivationcellsurfacereceptorsignalingpathwayestablishmentormaintenanceofcellpolaritygamma-deltaTcellactivationpositivethymicTcellselectionproteintransportprotein-containingcomplexassemblyregulationoflymphocyteapoptoticprocessTcellactivationTcellreceptorsignalingpathway
MHC class I antigen
2.1
82
83
A0A583ZB34A0A583ZB34A0A583ZB34A0A583ZB34antigenprocessingandpresentationimmuneresponse
5-hydroxytryptamine receptor 2B
2.0
31
89
5HT2B5HT2BP41595P41595activationofphospholipaseCactivitybehaviorcalcium-mediatedsignalingcardiacmusclehypertrophycellularcalciumionhomeostasiscellularresponsetotemperaturestimuluscGMP-mediatedsignalingchemicalsynaptictransmissionembryonicmorphogenesisERK1andERK2cascadeGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerGprotein-coupledserotoninreceptorsignalingpathwayheartmorphogenesisintestinesmoothmusclecontractionnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcelldeathneuralcrestcelldifferentiationneuralcrestcellmigrationphosphatidylinositol3-kinasesignalingphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayphospholipaseC-activatingserotoninreceptorsignalingpathwayphosphorylationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofMAPkinaseactivitypositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphosphatidylinositolbiosyntheticprocessproteinkinaseCsignalingproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofbehaviorreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusvasoconstriction
Amiloride-sensitive sodium channel subunit beta
2.0
48
85
SCNNBSCNNBP51168P51168aldosteronemetabolicprocessarterysmoothmusclecontractioncellularresponsetoacidicpHcellularresponsetoaldosteronecellularresponsetoamiloridecellularresponsetovasopressincellularsodiumionhomeostasisepithelialfluidtransporterythrocytehomeostasisgeneexpressionleukocyteactivationinvolvedininflammatoryresponsemucussecretionmulticellularorganismgrowthmulticellularorganismalwaterhomeostasisneutrophilactivationinvolvedinimmuneresponseneutrophil-mediatedkillingofbacteriumpotassiumionhomeostasisregulationofbloodpressureresponsetofoodresponsetoxenobioticstimulussensoryperceptionofsaltytastesensoryperceptionofsourtastesodiumionhomeostasissodiumionimportacrossplasmamembranesodiumiontransmembranetransportsodiumiontransportureahomeostasis
Interferon lambda-3
2.0
36
88
IFNL3IFNL3Q8IZI9Q8IZI9cellularresponsetovirusdefenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofimmuneresponsereceptorsignalingpathwayviaJAK-STATtypeIIIinterferon-mediatedsignalingpathway
Dipeptidyl peptidase 2
2.0
64
85
DPP2DPP2Q9UHL4Q9UHL4lysosomalproteincatabolicprocessproteolysis
MHC class I polypeptide-related sequence B
2.0
74
81
MICBMICBP79525P79525adaptiveimmuneresponsecytolysisgamma-deltaTcellactivationimmuneresponse-activatingcellsurfacereceptorsignalingpathwaynegativeregulationofdefenseresponsetovirusbyhostresponsetoheatresponsetooxidativestressresponsetoretinoicacid
C4b-binding protein alpha chain
2.0
52
88
C4BPAC4BPAP04003P04003complementactivationclassicalpathwayinnateimmuneresponsenegativeregulationofcomplementactivationclassicalpathwaypositiveregulationofproteincatabolicprocessregulationofopsonizationresponsetosymbioticbacterium
MHC class I antigen
2.0
78
83
B2KT53B2KT53B2KT53B2KT53antigenprocessingandpresentationimmuneresponse
Folate receptor alpha
2.0
49
86
FOLR1FOLR1P15328P15328anteriorneuraltubeclosureaxonregenerationcardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscelladhesioncellularresponsetofolicacidfolicacidmetabolicprocessfolicacidtransportfusionofspermtoeggplasmamembraneinvolvedinsinglefertilizationheartloopingneuralcrestcellmigrationinvolvedinheartformationpharyngealarcharterymorphogenesisreceptor-mediatedendocytosisregulationofcanonicalWntsignalingpathwayregulationoftransforminggrowthfactorbetareceptorsignalingpathwayrenalabsorptionsperm-eggrecognition
Polymeric immunoglobulin receptor
2.0
44
88
PIGRPIGRP01833P01833detectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteepidermalgrowthfactorreceptorsignalingpathwayFcreceptorsignalingpathwayimmunoglobulintranscytosisinepithelialcellsmediatedbypolymericimmunoglobulinreceptorreceptorclusteringretinahomeostasis
CD180 molecule
2.0
nan
90
A6QNK7A6QNK7A6QNK7A6QNK7
Thrombomodulin
2.0
nan
90
TRBMTRBMP07204P07204bloodcoagulationbloodcoagulationcommonpathwayfemalepregnancynegativeregulationofbloodcoagulationnegativeregulationoffibrinolysisnegativeregulationofplateletactivationproteolysisresponsetocAMPresponsetolipopolysaccharideresponsetoX-rayzymogenactivation
Mitochondrial import inner membrane translocase subunit Tim10 B
2.0
70
81
T10BT10BQ9Y5J6Q9Y5J6cell-matrixadhesionproteininsertionintomitochondrialinnermembrane
High affinity immunoglobulin epsilon receptor subunit alpha
2.0
82
81
FCERAFCERAP12319P12319cellsurfacereceptorsignalingpathwayregulationofimmuneresponse
HLA class II histocompatibility antigen DQ beta chain
2.0
89
80
A0A0U5IHY9A0A0U5IHY9A0A0U5IHY9A0A0U5IHY9adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Defensin beta 4A
2.0
63
83
DFB4ADFB4AO15263O15263antifungalinnateimmuneresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxischemotaxisdefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdisruptionofcellsofanotherorganismGprotein-coupledreceptorsignalingpathwayimmuneresponsekillingofcellsofanotherorganism
Alpha-galactosidase A
2.0
72
83
AGALAGALP06280P06280glycosidecatabolicprocessglycosphingolipidcatabolicprocessglycosylceramidecatabolicprocessnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofnitric-oxidesynthaseactivityoligosaccharidemetabolicprocess
Fibrinogen gamma-B chain
2.0
64
85
FIBBFIBGP02675Q53Y18adaptiveimmuneresponsebloodcoagulationfibrinclotformationcelladhesioncell-matrixadhesioncellularresponsetointerleukin-1cellularresponsetoleptinstimulusfibrinolysisinductionofbacterialagglutinationinnateimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsplasminogenactivationplateletaggregationpositiveregulationofERK1andERK2cascadepositiveregulationofexocytosispositiveregulationofheterotypiccell-celladhesionpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinsecretionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvasoconstrictionproteinpolymerizationprotein-containingcomplexassemblyresponsetocalciumioncellularresponsetointerleukin-6negativeregulationofplateletaggregationplateletmaturationproteinsecretion
Neural cell adhesion molecule 2
2.0
74
83
NCAM2NCAM2O15394O15394axonalfasciculationneuroncell-celladhesionsensoryperceptionofsmell
MHC class I antigen
2.0
79
82
U5YJK1U5YJK1U5YJK1U5YJK1
Interleukin-6 receptor subunit beta
2.1
nan
88
IL6RBIL6RBP40189P40189ciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwayglycogenmetabolicprocessinterleukin-27-mediatedsignalingpathwayinterleukin-6-mediatedsignalingpathwayintestinalepithelialcelldevelopmentleukemiainhibitoryfactorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofinterleukin-6-mediatedsignalingpathwaynegativeregulationofneuronapoptoticprocessoncostatin-M-mediatedsignalingpathwaypositiveregulationofacuteinflammatoryresponsepositiveregulationofadaptiveimmuneresponsepositiveregulationofastrocytedifferentiationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcellpopulationproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofosteoblastdifferentiationpositiveregulationofplateletaggregationpositiveregulationofTcellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularendothelialgrowthfactorproductionresponsetocytokine
PRSS3 protein
2.0
62
87
Q8N2U3Q8N2U3Q8N2U3Q8N2U3proteolysis
Protein KIBRA
2.0
52
86
KIBRAKIBRAQ8IX03Q8IX03cellmigrationestablishmentofcellpolaritynegativeregulationofhipposignalingnegativeregulationoforgangrowthnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofMAPKcascaderegulationofDNA-templatedtranscriptionregulationofhipposignalingregulationofintracellulartransport
Cathepsin F
2.0
55
86
CATFCATFQ9UBX1Q9UBX1antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIproteolysisproteolysisinvolvedinproteincatabolicprocess
Noelin
2.0
67
83
NOE1NOE1O88998O88998atrioventricularvalveformationcardiacepithelialtomesenchymaltransitionnegativeregulationofgeneexpressionneuronalsignaltransductionpositiveregulationofapoptoticprocesspositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionregulationofaxonextensionsignaltransduction
Cathepsin L2
2.0
57
85
CATL2CATL2O60911O60911antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIextracellularmatrixdisassemblyimmuneresponseproteolysisinvolvedinproteincatabolicprocess
Receptor activity-modifying protein 1
2.0
52
87
RAMP1RAMP1O60894O60894adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwayangiogenesiscalcitoningene-relatedpeptidereceptorsignalingpathwaycalciumiontransportcellularresponsetohormonestimulusGprotein-coupledreceptorsignalingpathwayintracellularproteintransportpositiveregulationofproteinglycosylationproteinlocalizationtoplasmamembraneproteintransportreceptorinternalizationregulationofGprotein-coupledreceptorsignalingpathway
Protocadherin gamma C4
2.0
54
86
Q91XX0Q91XX0Q91XX0Q91XX0homophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofneuronapoptoticprocesssynapseorganization
Glutamate receptor ionotropic, NMDA 3A
2.0
36
87
NMD3ANMD3AQ9R1M7Q9R1M7calciumiontransportchemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticdendritedevelopmentiontransmembranetransportionotropicglutamatereceptorsignalingpathwaynegativeregulationofdendriticspinedevelopmentprepulseinhibitionpresynapticmodulationofchemicalsynaptictransmissionregulationofpostsynapticmembranepotentialregulationofsynapticvesicleexocytosisresponsetoethanolrhythmicprocess
Killer cell lectin-like receptor subfamily G member 1
2.0
nan
88
KLRG1KLRG1Q96E93Q96E93cellsurfacereceptorsignalingpathwaycellulardefenseresponseinflammatoryresponseinnateimmuneresponse
5-hydroxytryptamine receptor 2C
2.0
33
88
5HT2C5HT2CP28335P28335behavioralfearresponsecellularcalciumionhomeostasiscGMP-mediatedsignalingchemicalsynaptictransmissionfeedingbehaviorGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerGprotein-coupledserotoninreceptorsignalingpathwaylocomotorybehaviorphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayphospholipaseC-activatingserotoninreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofERK1andERK2cascadepositiveregulationoffatcelldifferentiationpositiveregulationofphosphatidylinositolbiosyntheticprocessregulationofappetiteregulationofcorticotropin-releasinghormonesecretionregulationofnervoussystemprocessreleaseofsequesteredcalciumionintocytosol
Protocadherin beta 6
2.0
54
85
B2RWV0B2RWV0B2RWV0B2RWV0homophiliccelladhesionviaplasmamembraneadhesionmolecules
Endothelin receptor type B
2.0
nan
88
EDNRBEDNRBP24530P24530agingaldosteronemetabolicprocesscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharidecGMP-mediatedsignalingdevelopmentalpigmentationendothelinreceptorsignalingpathwayentericnervoussystemdevelopmententericsmoothmusclecelldifferentiationepithelialfluidtransportestablishmentofendothelialbarriergeneexpressionheparinmetabolicprocessI-kappaBkinase/NF-kappaBsignalingmacrophagechemotaxismelanocytedifferentiationnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticprocessnegativeregulationofneuronmaturationnegativeregulationofproteinmetabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuralcrestcellmigrationneuroblastmigrationperipheralnervoussystemdevelopmentpharynxdevelopmentphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypodocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofpenileerectionpositiveregulationofproteinphosphorylationpositiveregulationofrenalsodiumexcretionpositiveregulationofurinevolumeposteriormidgutdevelopmentproteintransmembranetransportregulationofepithelialcellproliferationregulationoffevergenerationregulationofheartrateregulationofpHregulationofsensoryperceptionofpainrenalalbuminabsorptionrenalsodiumexcretionrenalsodiumionabsorptionreninsecretionintobloodstreamresponsetoendothelinresponsetoorganiccycliccompoundresponsetopainresponsetosodiumphosphatesensoryperceptionofpainvasoconstrictionvasodilationveinsmoothmusclecontraction
Angiopoietin-2
2.0
53
85
ANGP2ANGP2O15123O15123angiogenesisanimalorganregenerationcellularresponsetogrowthfactorstimulusgeneexpressiongermcelldevelopmentglomerulusvasculaturedevelopmentmaternalprocessinvolvedinfemalepregnancynegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcell-substrateadhesionnegativeregulationofpositivechemotaxispositiveregulationofangiogenesisresponsetoactivityresponsetoglucoseresponsetohypoxiaresponsetomechanicalstimulusresponsetoorganiccycliccompoundresponsetoradiationsignaltransductionTiesignalingpathway
ALK and LTK ligand 2
2.0
48
90
ALKL2ALKL2Q6UX46Q6UX46positiveregulationofERK1andERK2cascadepositiveregulationofERK5cascadepositiveregulationofneuronprojectiondevelopment
Advanced glycosylation end product-specific receptor
2.0
72
85
RAGERAGEQ15109Q15109astrocyteactivationcellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betaglucosemediatedsignalingpathwayinductionofpositivechemotaxisinflammatoryresponselearningormemorymicroglialcellactivationnegativeregulationofbloodcirculationnegativeregulationofinterleukin-10productionnegativeregulationoflong-termsynapticdepressionnegativeregulationoflong-termsynapticpotentiationneuronprojectiondevelopmentpositiveregulationofactivatedTcellproliferationpositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofchemokineproductionpositiveregulationofdendriticcelldifferentiationpositiveregulationofendothelinproductionpositiveregulationofERK1andERK2cascadepositiveregulationofheterotypiccell-celladhesionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofmonocytechemotacticprotein-1productionpositiveregulationofmonocyteextravasationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofp38MAPKcascadepositiveregulationofproteinphosphorylationpositiveregulationoftumornecrosisfactorproductionproteinlocalizationtomembraneregulationofCD4-positivealpha-betaTcellactivationregulationofDNAbindingregulationofinflammatoryresponseregulationoflong-termsynapticpotentiationregulationofNIK/NF-kappaBsignalingregulationofp38MAPKcascaderegulationofspontaneoussynaptictransmissionregulationofsynapticplasticityregulationofTcellmediatedcytotoxicityresponsetoamyloid-betaresponsetohypoxiaresponsetowoundingtranscytosistransportacrossblood-brainbarrier
C-type lectin domain family 2 member A
2.0
54
86
CLC2ACLC2AQ6UVW9Q6UVW9naturalkillercellmediatedcytotoxicity
Complement factor H-related protein 1
2.0
nan
89
FHR1FHR1Q03591Q03591complementactivationcytolysisbyhostofsymbiontcellsnegativeregulationofproteinbinding
Beta-secretase 2
2.0
60
87
BACE2BACE2Q9Y5Z0Q9Y5Z0amyloid-betametabolicprocessglucosehomeostasismelanosomeorganizationmembraneproteinectodomainproteolysisnegativeregulationofamyloidprecursorproteinbiosyntheticprocesspeptidehormoneprocessingproteinprocessingproteolysis
Coagulation factor X
2.0
nan
90
FA10FA10P00742P00742bloodcoagulationbloodcoagulationcommonpathwaypositiveregulationofcellmigrationpositiveregulationofproteinkinaseBsignalingproteolysiszymogenactivation
Platelet glycoprotein Ib alpha chain
2.0
42
87
GP1BAGP1BAP07359P07359bloodcoagulationbloodcoagulationintrinsicpathwaycelladhesioncellmorphogenesiscellsurfacereceptorsignalingpathwayfibrinolysismegakaryocytedevelopmentplateletactivationplateletaggregationpositiveregulationofleukocytetetheringorrollingpositiveregulationofplateletactivationregulationofbloodcoagulationreleaseofsequesteredcalciumionintocytosol
Tryptase alpha/beta-1
2.0
71
84
TRYB1TRYB1P15157P15157defenseresponseextracellularmatrixdisassemblyproteolysis
IG c307_light_IGLV1-51_IGLJ2
2.0
94
78
A0A5C2GK82A0A5C2GK82A0A5C2GK82A0A5C2GK82
Mesothelin
2.0
51
86
MSLNMSLNQ13421Q13421celladhesioncell-matrixadhesionpancreasdevelopment
Gremlin-1
2.0
43
89
GREM1GREM1O60565O60565animalorganmorphogenesisapoptoticprocesscardiacmusclecelldifferentiationcardiacmusclecellmyoblastdifferentiationcellmigrationinvolvedinsproutingangiogenesiscellmorphogenesiscell-cellsignalingcollagenfibrilorganizationdeterminationofdorsalidentityembryoniclimbmorphogenesislimbdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofBMPsignalingpathwaynegativeregulationofbonemineralizationnegativeregulationofbonemineralizationinvolvedinbonematurationnegativeregulationofboneremodelingnegativeregulationofbonetrabeculaformationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofchondrocytedifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofmonocytechemotaxisnegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofosteoclastproliferationnegativeregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpeptidyl-tyrosineautophosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorinternalizationpositiveregulationofsignalingreceptoractivitypositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIproximal/distalpatternformationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblysequesteringofBMPfromreceptorviaBMPbindingsignaltransductionuretericbudformation
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2
2.0
nan
89
B3GN2B3GN2Q9NY97Q9NY97axonguidancecellularresponsetoleukemiainhibitoryfactorkeratansulfatebiosyntheticprocessO-glycanprocessingpoly-N-acetyllactosaminebiosyntheticprocesssensoryperceptionofsmell
Adenosine receptor A1
2.0
27
89
AA1RAA1RP30542P30542adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayapoptoticsignalingpathwaycell-cellsignalingcognitiondetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainexcitatorypostsynapticpotentialfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytemigrationlipidcatabolicprocesslong-termsynapticdepressionmucussecretionnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofcircadiansleep/wakecyclenon-REMsleepnegativeregulationofglutamatesecretionnegativeregulationofheartcontractionnegativeregulationofhormonesecretionnegativeregulationofleukocytemigrationnegativeregulationoflipidcatabolicprocessnegativeregulationoflong-termsynapticdepressionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmucussecretionnegativeregulationofneurotrophinproductionnegativeregulationofrenalsodiumexcretionnegativeregulationofsynaptictransmissionGABAergicnegativeregulationofsynaptictransmissionglutamatergicnegativeregulationofsystemicarterialbloodpressurenervoussystemdevelopmentphagocytosispositiveregulationofepidermalgrowthfactor-activatedreceptoractivitypositiveregulationoflipidcatabolicprocesspositiveregulationofMAPKcascadepositiveregulationofneurondeathpositiveregulationofnucleosidetransportpositiveregulationofpeptidesecretionpositiveregulationofpotassiumiontransportpositiveregulationofproteindephosphorylationpositiveregulationofsystemicarterialbloodpressureproteintargetingtomembraneregulationofcardiacmusclecellcontractionregulationofglomerularfiltrationregulationofpresynapticcytosoliccalciumionconcentrationregulationofrespiratorygaseousexchangebynervoussystemprocessregulationofsensoryperceptionofpainrelaxationofvascularassociatedsmoothmuscleresponsetohypoxiaresponsetoinorganicsubstanceresponsetopurine-containingcompoundsignaltransductiontemperaturehomeostasistriglyceridehomeostasis
Aspartyl/asparaginyl beta-hydroxylase
2.0
61
84
ASPHASPHQ12797Q12797activationofcysteine-typeendopeptidaseactivityactivationofstore-operatedcalciumchannelactivitycalciumionhomeostasiscalciumiontransmembranetransportcellpopulationproliferationcellularresponsetocalciumiondetectionofcalciumionfacemorphogenesislimbmorphogenesismusclecontractionnegativeregulationofcellpopulationproliferationpatternspecificationprocesspeptidyl-asparticacidhydroxylationpositiveregulationofcalciumiontransportintocytosolpositiveregulationofDNA-templatedtranscriptionpositiveregulationofintracellularproteintransportpositiveregulationofproteolysispositiveregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcellcommunicationbyelectricalcouplingregulationofinositol145-trisphosphate-sensitivecalcium-releasechannelactivityregulationofproteindepolymerizationregulationofproteinstabilityregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumregulationofryanodine-sensitivecalcium-releasechannelactivityresponsetoATProofofmouthdevelopment
Phospholipase A2, membrane associated
2.0
nan
86
PA2GAPA2GAP14555P14555arachidonicacidsecretioncytolysisdefenseresponsetoGram-positivebacteriuminflammatoryresponseintestinalstemcellhomeostasislipidcatabolicprocesslow-densitylipoproteinparticleremodelingphosphatidicacidmetabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminemetabolicprocessphospholipidmetabolicprocesspositiveregulationofERK1andERK2cascadepositiveregulationofinflammatoryresponsepositiveregulationofmacrophagederivedfoamcelldifferentiationregulationofneutrophilactivation
Endoplasmic reticulum aminopeptidase 1
2.0
79
80
ERAP1ERAP1Q9NZ08Q9NZ08adaptiveimmuneresponseangiogenesisantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofpeptideantigenviaMHCclassIfatcelldifferentiationmembraneproteinectodomainproteolysispeptidecatabolicprocesspositiveregulationofangiogenesisproteolysisregulationofbloodpressureregulationofinnateimmuneresponseresponsetobacteriumsignaltransduction
MHC class II HLA-DQ-alpha chain
2.0
79
78
O19705O19705O19705O19705adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Protocadherin-17
2.0
52
86
PCD17PCD17O14917O14917adultbehaviorcelladhesionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofsynaptictransmissionpresynapticactivezoneassemblyregulationofsynapticvesicleclusteringsynapticmembraneadhesion
Insulin-like growth factor II
2.0
54
86
IGF2IGF2P01344P01344animalorganmorphogenesisembryonicplacentadevelopmentembryonicplacentamorphogenesisexocrinepancreasdevelopmentglucosemetabolicprocessinuteroembryonicdevelopmentinsulinreceptorsignalingpathwayinsulinreceptorsignalingpathwayviaphosphatidylinositol3-kinaseinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofmusclecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastdifferentiationpositiveregulationofactivatedTcellproliferationpositiveregulationofcatalyticactivitypositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofglycogen(starch)synthaseactivitypositiveregulationofglycogenbiosyntheticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofmulticellularorganismgrowthpositiveregulationoforgangrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofskeletalmuscletissuegrowthpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialcellproliferationregulationofDNA-templatedtranscriptionregulationofgeneexpressionbygenomicimprintingregulationofhistonemodificationregulationofmusclecelldifferentiationspongiotrophoblastcellproliferationstriatedmusclecelldifferentiation
Plasminogen
3.6
73
86
PLMNPLMNP00747P00747biologicalprocessinvolvedininteractionwithsymbiontbloodcoagulationextracellularmatrixdisassemblyfibrinolysisnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcell-substrateadhesionnegativeregulationoffibrinolysispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationoffibrinolysisproteolysistissueremodeling
Transcobalamin-1
2.0
61
85
TCO1TCO1P20061P20061cobalamintransportcobaltiontransport
HF protein
2.0
53
87
Q14006Q14006Q14006Q14006
MHC class I antigen
2.0
79
83
O19244O19244O19244O19244antigenprocessingandpresentationimmuneresponse
UL16-binding protein 6
2.0
69
84
ULBP6ULBP6Q5VY80Q5VY80immunesystemprocess
Igh protein
2.0
81
81
Q99LC4Q99LC4Q99LC4Q99LC4
Beta-hexosaminidase subunit alpha
2.0
67
87
✔
HEXAHEXAP06865P06865adultwalkingbehaviorcarbohydratemetabolicprocesscellmorphogenesisinvolvedinneurondifferentiationdermatansulfatecatabolicprocessgangliosidecatabolicprocessglycosaminoglycanbiosyntheticprocessglycosaminoglycanmetabolicprocesshyaluronancatabolicprocesslipidstoragelysosomeorganizationmaintenanceoflocationincellmyelinationneuromuscularprocesscontrollingbalanceneuromuscularprocesscontrollingposturesensoryperceptionofsoundsexualreproductionskeletalsystemdevelopmentSMADproteinsignaltransduction
High affinity immunoglobulin gamma Fc receptor I
2.0
65
84
FCGR1FCGR1P12314P12314antibody-dependentcellularcytotoxicityantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIcellsurfacereceptorsignalingpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofphagocytosispositiveregulationofproteintyrosinekinaseactivitypositiveregulationoftypeIIahypersensitivitypositiveregulationoftypeIIIhypersensitivityreceptor-mediatedendocytosisregulationofimmuneresponsesignaltransduction
Protein sidekick-1
2.0
77
83
SDK1SDK1Q3UH53Q3UH53behavioralresponsetococainehomophiliccelladhesionviaplasmamembraneadhesionmoleculesregulationofdendriticspinedevelopmentretinalayerformationsynapseassembly
Prostaglandin G/H synthase 2
2.0
55
87
PGH2PGH2P35354P35354agingangiogenesisbonemineralizationbrownfatcelldifferentiationcellularresponsetoATPcellularresponsetofluidshearstresscellularresponsetoheatcellularresponsetohypoxiacellularresponsetoleadioncellularresponsetomechanicalstimuluscellularresponsetonon-ionicosmoticstresscellularresponsetoUVcyclooxygenasepathwaydecidualizationembryoimplantationhaircycleinflammatoryresponselearningmaintenanceofblood-brainbarriermemorynegativeregulationofcalciumiontransportnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressnegativeregulationofsmoothmusclecontractionnegativeregulationofsynaptictransmissiondopaminergicovulationpositiveregulationofapoptoticprocesspositiveregulationofbrownfatcelldifferentiationpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationoffevergenerationpositiveregulationoffibroblastgrowthfactorproductionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofplatelet-derivedgrowthfactorproductionpositiveregulationofprostaglandinbiosyntheticprocesspositiveregulationofproteinimportintonucleuspositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationofsynapticplasticitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftransforminggrowthfactorbetaproductionpositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvasoconstrictionprostaglandinbiosyntheticprocessprostaglandinsecretionregulationofbloodpressureregulationofinflammatoryresponseregulationofneuroinflammatoryresponseresponsetoangiotensinresponsetoestradiolresponsetofattyacidresponsetofructoseresponsetoglucocorticoidresponsetolipopolysaccharideresponsetolithiumionresponsetomanganeseionresponsetonematoderesponsetooxidativestressresponsetotumornecrosisfactorresponsetovitaminDresponsetoxenobioticstimulussensoryperceptionofpain
HLA class I histocompatibility antigen B alpha chain
2.0
83
80
Q546I9Q546I9Q546I9Q546I9antigenprocessingandpresentationimmuneresponse
Cysteinyl leukotriene receptor 2
2.0
37
88
CLTR2CLTR2Q9NS75Q9NS75cellularresponsetoglucagonstimulusimmuneresponseneuropeptidesignalingpathway
Neutrophil defensin 1
2.0
52
87
DEF1DEF1P59665P59665antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemotaxisdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponseinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingbyhostofsymbiontcellskillingofcellsofanotherorganismTcellchemotaxis
Poliovirus receptor
2.0
72
84
PVRPVRP15151P15151heterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomophiliccelladhesionviaplasmamembraneadhesionmoleculespositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetsusceptibilitytonaturalkillercellmediatedcytotoxicitysusceptibilitytoTcellmediatedcytotoxicity
Endoplasmic reticulum aminopeptidase 2
2.0
62
80
ERAP2ERAP2Q6P179Q6P179adaptiveimmuneresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofpeptideantigenviaMHCclassIpeptidecatabolicprocessproteolysisregulationofbloodpressuresignaltransduction
Peptidoglycan recognition protein 3
2.0
45
86
PGRP3PGRP3Q96LB9Q96LB9antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebiologicalprocessinvolvedininteractionwithhostdefenseresponsetoGram-positivebacteriumdetectionofbacteriuminnateimmuneresponsekillingofcellsofanotherorganismnegativeregulationofnaturalkillercelldifferentiationinvolvedinimmuneresponsenegativeregulationoftypeIIinterferonproductionpeptidoglycancatabolicprocess
Tyrosine-protein kinase receptor UFO
2.0
82
82
UFOUFOP30530P30530animalorganregenerationbloodvesselremodelingcellmaturationcellmigrationcellularresponsetoextracellularstimuluscellularresponsetohydrogenperoxidecellularresponsetointerferon-alphacellularresponsetolipopolysaccharidedendriticcelldifferentiationerythrocytehomeostasisestablishmentoflocalizationincellforebraincellmigrationinflammatoryresponseinnateimmuneresponsenaturalkillercelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofdendriticcellapoptoticprocessnegativeregulationoflymphocyteactivationnegativeregulationofmacrophagecytokineproductionnegativeregulationofneuronapoptoticprocessnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionnervoussystemdevelopmentneuronapoptoticprocessneuronmigrationneutrophilclearanceovulationcyclephagocytosisplateletactivationpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofkinaseactivitypositiveregulationofnaturalkillercelldifferentiationpositiveregulationofpinocytosispositiveregulationofproteinkinaseBsignalingpositiveregulationofvirallifecycleproteinkinaseBsignalingresponsetoaxoninjurysecretionbycellsignaltransductionspermatogenesissubstrateadhesion-dependentcellspreadingtransmembranereceptorproteintyrosinekinasesignalingpathwayvaginadevelopmentvascularendothelialgrowthfactorreceptorsignalingpathwayviralentryintohostcell
Thioredoxin reductase 1, cytoplasmic
2.0
75
84
✔
TRXR1THIOQ16881P10599cellpopulationproliferationcellredoxhomeostasismesodermformationsignaltransductionactivationofproteinkinaseBactivitynegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiation
NPC intracellular cholesterol transporter 2
2.0
57
87
NPC2NPC2P61916P61916cholesteroleffluxcholesterolhomeostasischolesterolmetabolicprocesscholesteroltransportglycolipidtransportintracellularcholesteroltransportintracellularsteroltransportphospholipidtransportregulationofisoprenoidmetabolicprocessresponsetovirussteroltransport
MHC class I antigen
2.0
79
82
Q56H30Q56H30Q56H30Q56H30
Cysteinyl leukotriene receptor 1
2.0
nan
92
CLTR1CLTR1Q9Y271Q9Y271calciumiontransportcellsurfacereceptorsignalingpathwaychemotaxisdefenseresponseestablishmentoflocalizationincellinflammatoryresponsetoantigenicstimulusneuropeptidesignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationrespiratorygaseousexchangebyrespiratorysystem
Vasopressin-neurophysin 2-copeptin
2.0
nan
89
NEU2NEU2P01185P01185cell-cellsignalingERK1andERK2cascadegenerationofprecursormetabolitesandenergygroomingbehaviorhyperosmoticsalinityresponselocomotorybehaviormaternalaggressivebehaviormaternalbehaviormulticellularorganismalwaterhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationoffemalereceptivitynegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationoftransmissionofnerveimpulsepenileerectionpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcellularpHreductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofgeneexpressionpositiveregulationofglutamatesecretionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofprostaglandinbiosyntheticprocesspositiveregulationofsystemicarterialbloodpressurepositiveregulationofvasoconstrictionproteinkinaseCsignalingregulationofrenalsodiumexcretionresponsetoethanolresponsetonicotineresponsetotestosteronesignaltransductionsocialbehaviorvasoconstrictionviralentryintohostcellwatertransport
Leukotriene B4 receptor 1
2.0
65
84
LT4R1LT4R1Q15722Q15722Gprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsemusclecontractionneuropeptidesignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathway
N-acylethanolamine-hydrolyzing acid amidase
2.0
74
83
NAAANAAAQ02083Q02083fattyacidmetabolicprocesslipidcatabolicprocessN-acylethanolaminemetabolicprocessN-acylphosphatidylethanolaminemetabolicprocesssphingosinemetabolicprocess
Peptidylglycine alpha-amidating monooxygenase
2.0
64
84
AMDAMDP14925P14925centralnervoussystemdevelopmentfattyacidprimaryamidebiosyntheticprocessheartdevelopmentlactationlimbdevelopmentlong-chainfattyacidmetabolicprocessmaternalprocessinvolvedinfemalepregnancymitoticchromosomecondensationodontogenesisovulationcycleprocesspeptideamidationpeptidemetabolicprocessproteinamidationproteinmetabolicprocessregulationofactincytoskeletonorganizationregulationofproteinsecretionregulationoftranscriptionbyRNApolymeraseIIresponsetocopperionresponsetoestradiolresponsetoglucocorticoidresponsetohypoxiaresponsetopHresponsetoxenobioticstimulusresponsetozinciontoxinmetabolicprocess
Protein kinase C-binding protein NELL1
2.0
55
88
NELL1NELL1Q92832Q92832celldifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnervoussystemdevelopmentpositiveregulationofbonemineralizationpositiveregulationofosteoblastdifferentiationregulationofgeneexpression
Iduronate 2-sulfatase
2.0
63
83
IDSIDSP22304P22304dermatansulfatecatabolicprocessglycosaminoglycancatabolicprocessheparansulfateproteoglycancatabolicprocess
Serine/threonine-protein kinase receptor R3
2.0
47
88
ACVL1ACVL1P37023P37023angiogenesisarterydevelopmentbloodcirculationbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisbloodvesselmaturationbloodvesselremodelingBMPsignalingpathwaycellularresponsetoBMPstimuluscellularresponsetogrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimulusdorsalaortamorphogenesisdorsal/ventralpatternformationendocardialcushionmorphogenesisendothelialtubemorphogenesisheartdevelopmentinuteroembryonicdevelopmentlymphangiogenesislymphaticendothelialcelldifferentiationnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcelladhesionnegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofDNAbiosyntheticprocessnegativeregulationofendothelialcelldifferentiationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationnegativeregulationoffocaladhesionassemblynegativeregulationofgeneexpressionpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofbloodpressureregulationofbloodvesselendothelialcellmigrationregulationofDNAreplicationregulationofDNA-templatedtranscriptionregulationofendothelialcellproliferationresponsetohypoxiaretinavasculaturedevelopmentincamera-typeeyesignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayvenousbloodvesseldevelopmentwoundhealingspreadingofepidermalcells
MHC class I antigen
2.0
81
82
A0A5B8RNS7A0A5B8RNS7A0A5B8RNS7A0A5B8RNS7
MHC class I antigen
2.0
78
82
F6IQY1F6IQY1F6IQY1F6IQY1
Sphingosine 1-phosphate receptor 5
2.0
38
88
S1PR5S1PR5Q9H228Q9H228adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayregulationofmetabolicprocessregulationofneurondifferentiation
Interleukin-12 subunit alpha
2.1
nan
88
IL12BIL12AP29460P29459cellmigrationcellularresponsetolipopolysaccharidecellularresponsetotypeIIinterferoncytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponsenaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcelladhesionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationoflymphocyteproliferationpositiveregulationofmemoryTcelldifferentiationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnaturalkillercellproliferationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftissueremodelingpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcytokineproductionregulationoftyrosinephosphorylationofSTATproteinresponsetoUV-BsensoryperceptionofpainsexualreproductionTcellproliferationT-helper1typeimmuneresponseT-helpercelldifferentiationcellularresponsetovirusdefenseresponsetoGram-positivebacteriumextrinsicapoptoticsignalingpathwaypositiveregulationofdendriticcellchemotaxispositiveregulationofnaturalkillercellmediatedcytotoxicityresponsetolipopolysaccharideresponsetovirus
Polypeptide N-acetylgalactosaminyltransferase 10
2.0
58
86
GLT10GLT10Q86SR1Q86SR1O-glycanprocessingproteinO-linkedglycosylation
5,6-dihydroxyindole-2-carboxylic acid oxidase
2.0
54
87
TYRP1TYRP1P17643P17643acetoaceticacidmetabolicprocessmelaninbiosyntheticprocessmelanocytedifferentiationmelanosomeorganizationpositiveregulationofmelaninbiosyntheticprocess
Killer cell immunoglobulin-like receptor 2DL4
2.0
77
86
KI2L4KI2L4Q99706Q99706cellulardefenseresponsenegativeregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofcellularsenescencepositiveregulationofnaturalkillercellcytokineproductionsignaltransduction
Uncharacterized protein DKFZp686C11235
2.1
nan
92
Q6MZV7Q6MZV7Q6MZV7Q6MZV7
Immunoblobulin light chain
2.0
87
80
Q0KKI6Q0KKI6Q0KKI6Q0KKI6
T-complex protein 1 subunit gamma
2.0
73
86
TCPGTCPGP80318P80318bindingofspermtozonapellucidachaperone-mediatedproteinfoldingporecomplexassemblypositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationtoxintransport
Glial cell line-derived neurotrophic factor
2.0
58
88
GDNFGDNFP39905P39905adultlocomotorybehaviorbranchinginvolvedinuretericbudmorphogenesiscommissuralneuronaxonguidancedorsalspinalcorddevelopmentembryonicorgandevelopmententericnervoussystemdevelopmentmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesismetanephrosdevelopmentmRNAstabilizationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentneuralcrestcellmigrationneuronprojectiondevelopmentorganinductionperipheralnervoussystemdevelopmentperistalsispositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofdopaminesecretionpositiveregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesispositiveregulationofmonooxygenaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationpostganglionicparasympatheticfiberdevelopmentpostsynapticmembraneorganizationregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofgeneexpressionregulationofmorphogenesisofabranchingstructureregulationofsemaphorin-plexinsignalingpathwayregulationofstemcelldifferentiationsignaltransductionsympatheticnervoussystemdevelopmenturetericbudformation
Ig-like domain-containing protein
2.0
80
81
F6RL33F6RL33F6RL33F6RL33
Sortilin
2.0
nan
87
SORTSORTQ6PHU5Q6PHU5endocytosisendosometolysosometransportendosometransportviamultivesicularbodysortingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsGprotein-coupledreceptorsignalingpathwayglucoseimportGolgitoendosometransportGolgitolysosometransportmaintenanceofsynapsestructuremyotubedifferentiationnegativeregulationoffatcelldifferentiationnegativeregulationoflipoproteinlipaseactivityneuropeptidesignalingpathwayneurotrophinTRKreceptorsignalingpathwayossificationplasmamembranetoendosometransportpositiveregulationofepithelialcellapoptoticprocesspost-Golgivesicle-mediatedtransportproteintargetingtolysosomeregulationofgeneexpressionresponsetoinsulinvesicleorganization
Cd1d1 protein
2.0
81
80
Q7TMK5Q7TMK5Q7TMK5Q7TMK5
E3 ubiquitin-protein ligase ZNRF3
2.0
42
85
ZNRF3ZNRF3Q5SSZ7Q5SSZ7limbdevelopmentnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofnon-canonicalWntsignalingpathwaynegativeregulationofWntsignalingpathwayproteinubiquitinationregulationofcanonicalWntsignalingpathwayregulationofWntsignalingpathwayplanarcellpolaritypathwaystemcellproliferationubiquitin-dependentproteincatabolicprocessWntreceptorcatabolicprocessWntsignalingpathway
Parathyroid hormone/parathyroid hormone-related peptide receptor
2.0
59
87
PTH1RPTH1RQ03431Q03431adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaybonemineralizationboneresorptioncellmaturationcellpopulationproliferationcellsurfacereceptorsignalingpathwaycellularcalciumionhomeostasischondrocytedifferentiationGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerinuteroembryonicdevelopmentnegativeregulationofcellpopulationproliferationosteoblastdevelopmentphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofinositolphosphatebiosyntheticprocessskeletalsystemdevelopment
Leukocyte immunoglobulin-like receptor subfamily B member 1
2.0
78
83
LIRB1LIRB1Q8NHL6Q8NHL6adaptiveimmuneresponsecellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwaydefenseresponsetovirusdendriticcelldifferentiationFcreceptormediatedinhibitorysignalingpathwayimmuneresponse-inhibitingcellsurfacereceptorsignalingpathwaynegativeregulationofalpha-betaTcellactivationnegativeregulationofcalciumiontransportnegativeregulationofCD8-positivealpha-betaTcellactivationnegativeregulationofcellcyclenegativeregulationofcytokineproductioninvolvedinimmuneresponsenegativeregulationofdendriticcellapoptoticprocessnegativeregulationofdendriticcelldifferentiationnegativeregulationofendocytosisnegativeregulationofinterferon-betaproductionnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-12productionnegativeregulationofmononuclearcellproliferationnegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofosteoclastdevelopmentnegativeregulationofserotoninsecretionnegativeregulationofTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcellnegativeregulationofTcellmediatedcytotoxicitynegativeregulationofTcellproliferationnegativeregulationoftransforminggrowthfactorbetaproductionnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionpositiveregulationofapoptoticprocesspositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgamma-deltaTcellactivationinvolvedinimmuneresponsepositiveregulationofgeneexpressionpositiveregulationofmacrophagecytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionreceptorinternalizationresponsetovirussignaltransductionTcellproliferationinvolvedinimmuneresponse
Alpha glucosidase 2 alpha neutral subunit
2.0
70
86
A1A4T2A1A4T2A1A4T2A1A4T2carbohydratemetabolicprocessN-glycanprocessing
Ephrin-A5
2.0
68
85
EFNA5EFNA5O08543O08543axonguidancebraindevelopmentcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoforskolincollateralsproutingephrinreceptorsignalingpathwaynegativeregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofcollateralsproutingpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofsynapseassemblyregulationofactincytoskeletonorganizationregulationofcellmorphogenesisregulationofcell-celladhesionregulationoffocaladhesionassemblyregulationofGTPaseactivityregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusregulationofmicrotubulecytoskeletonorganizationretinalganglioncellaxonguidancesynapticmembraneadhesion
Interferon 1ai7
2.0
49
86
B1AYH7B1AYH7B1AYH7B1AYH7defenseresponsetovirus
MHC class I antigen
2.0
77
82
U5YKE0U5YKE0U5YKE0U5YKE0
Metabotropic glutamate receptor 8
2.0
41
88
GRM8GRM8O00222O00222adenylatecyclase-inhibitingGprotein-coupledglutamatereceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayGprotein-coupledglutamatereceptorsignalingpathwayregulationofsynaptictransmissionglutamatergicvisualperception
Cx9C motif-containing protein 4
2.0
65
86
CMC4CMC4P56277P56277
Serotransferrin
2.0
53
86
TRFETRFEP02787P02787actinfilamentorganizationantibacterialhumoralresponsecellularironionhomeostasiscellularresponsetoironionERK1andERK2cascadeironionhomeostasisironiontransportosteoclastdifferentiationpositiveregulationofboneresorptionpositiveregulationofcellmotilitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofphosphorylationpositiveregulationofreceptor-mediatedendocytosisregulationofironiontransportregulationofproteinstabilityretinahomeostasisSMADproteinsignaltransduction
Tartrate-resistant acid phosphatase type 5
2.0
72
79
PPA5PPA5P09889P09889boneresorptioniontransportironionhomeostasis
Methionine synthase
2.0
71
79
METHMETHQ99707Q99707axonregenerationcellularresponsetonitricoxidecobalaminmetabolicprocessmethioninebiosyntheticprocessmethylationnervoussystemdevelopmentpteridine-containingcompoundmetabolicprocessresponsetoaxoninjury
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
2.0
97
80
MA1B1MA1B1Q9UKM7Q9UKM7endoplasmicreticulummannosetrimmingmannosetrimminginvolvedinglycoproteinERADpathwayN-glycanprocessingoligosaccharidemetabolicprocessproteinalpha-12-demannosylationproteinglycosylationtrimmingoffirstmannoseonAbranchtrimmingofsecondmannoseonAbranchtrimmingofterminalmannoseonBbranchtrimmingofterminalmannoseonCbranchubiquitin-dependentERADpathwayviralproteinprocessing
Interferon gamma receptor 1
2.0
59
88
INGR1INGR1P15260P15260astrocyteactivationcellularresponsetoviruscytokine-mediatedsignalingpathwaymicroglialcellactivationnegativeregulationofamyloid-betaclearancepositiveregulationofamyloid-betaformationpositiveregulationofgeneexpressionpositiveregulationoftumornecrosisfactorproductionresponsetovirussignaltransductiontypeIIinterferon-mediatedsignalingpathway
Killer cell immunoglobulin-like receptor 2DL2
2.0
91
81
KI2L2KI2L2P43627P43627
Leukocyte surface antigen CD47
2.0
55
85
CD47CD47Q08722Q08722ATPexportcellmigrationcellularresponsetointerleukin-1cellularresponsetointerleukin-12cellularresponsetotypeIIinterferonintegrin-mediatedsignalingpathwaynegativeregulationofFc-gammareceptorsignalingpathwayinvolvedinphagocytosispositiveregulationofcellpopulationproliferationpositiveregulationofcell-celladhesionpositiveregulationofinflammatoryresponsepositiveregulationofmonocyteextravasationpositiveregulationofphagocytosispositiveregulationofstressfiberassemblypositiveregulationofTcellactivationregulationofinterleukin-10productionregulationofinterleukin-12productionregulationofinterleukin-6productionregulationofnitricoxidebiosyntheticprocessregulationoftumornecrosisfactorproductionregulationoftypeIIinterferonproduction
Lysophosphatidic acid phosphatase type 6
2.0
58
88
PPA6PPA6Q9NPH0Q9NPH0dephosphorylationhematopoieticprogenitorcelldifferentiationlysobisphosphatidicacidmetabolicprocessphosphatidicacidbiosyntheticprocessphospholipidmetabolicprocess
Gamma-crystallin S
2.0
67
80
CRYGSCRYGSP22914P22914lensdevelopmentincamera-typeeyemorphogenesisofanepitheliumvisualperception
R-spondin-1
2.1
nan
92
RSPO1RSPO1Q2MKA7Q2MKA7positiveregulationofcanonicalWntsignalingpathwaypositiveregulationofproteinphosphorylationpositiveregulationofWntsignalingpathwayregulationofreceptorinternalizationWntsignalingpathway
Human nkt tcr beta chain
2.0
82
82
K7N5M4K7N5M4K7N5M4K7N5M4
Muscarinic acetylcholine receptor M4
2.0
29
87
ACM4ACM4P08173P08173adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwaycellsurfacereceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerregulationoflocomotionsignaltransduction
T-cell-specific surface glycoprotein CD28
2.0
73
84
Q9N0N8Q9N0N8Q9N0N8Q9N0N8immuneresponsepositiveregulationofinterleukin-2productionpositiveregulationofmitoticnucleardivisionpositiveregulationofTcellproliferation
Receptor-type tyrosine-protein phosphatase gamma
2.0
61
86
PTPRGPTPRGP23470P23470braindevelopmentnegativeregulationofepithelialcellmigrationnegativeregulationofneuronprojectiondevelopmentproteindephosphorylationtransmembranereceptorproteintyrosinekinasesignalingpathway
Fractalkine
2.0
46
88
X3CL1X3CL1P78423P78423agingangiogenesisinvolvedinwoundhealingautocrinesignalingcelladhesioncellchemotaxiscell-celladhesioncell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydefenseresponseeosinophilchemotaxisextrinsicapoptoticsignalingpathwayinabsenceofligandGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseintegrinactivationleukocyteadhesiveactivationleukocytechemotaxisleukocytemigrationinvolvedininflammatoryresponselymphocytechemotaxismicroglialcellactivationmicroglialcellproliferationmonocytechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcell-substrateadhesionnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofglutamatereceptorsignalingpathwaynegativeregulationofhippocampalneuronapoptoticprocessnegativeregulationofinterleukin-1alphaproductionnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-6productionnegativeregulationofmicroglialcellactivationnegativeregulationofneuronmigrationnegativeregulationoftumornecrosisfactorproductionneuroncellularhomeostasisneuronremodelingneutrophilchemotaxispositivechemotaxispositiveregulationofactinfilamentbundleassemblypositiveregulationofcalcium-independentcell-celladhesionpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinflammatoryresponsepositiveregulationofMAPKcascadepositiveregulationofmicroglialcellmigrationpositiveregulationofneuroblastproliferationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbeta1productionregulationoflipopolysaccharide-mediatedsignalingpathwayregulationofneurogenesisregulationofsynapticplasticityresponsetoischemiasynapsepruning
Alkaline phosphatase, placental type
2.0
64
86
PPB1PPB1P05187P05187dephosphorylation
Trypsin-3
2.0
65
86
TRY3TRY3P35030P35030antimicrobialhumoralresponsedigestionendothelialcellmigrationproteolysiszymogenactivation
Slit homolog 2 protein
2.0
nan
91
SLIT2SLIT2O94813O94813aorticvalvemorphogenesisapoptoticprocessinvolvedinluteolysisaxonextensioninvolvedinaxonguidanceaxonguidancebranchingmorphogenesisofanepithelialtubecellmigrationinvolvedinsproutingangiogenesiscellularresponsetoheparincellularresponsetohormonestimuluschemorepulsioninvolvedinpostnatalolfactorybulbinterneuronmigrationcorticospinalneuronaxonguidancethroughspinalcordinductionofnegativechemotaxismotorneuronaxonguidancenegativechemotaxisnegativeregulationofactinfilamentpolymerizationnegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofcellularresponsetogrowthfactorstimulusnegativeregulationofchemokine-mediatedsignalingpathwaynegativeregulationofendothelialcellmigrationnegativeregulationoflamellipodiumassemblynegativeregulationofleukocytechemotaxisnegativeregulationofmonocytechemotaxisnegativeregulationofmononuclearcellmigrationnegativeregulationofneutrophilchemotaxisnegativeregulationofproteinphosphorylationnegativeregulationofretinalganglioncellaxonguidancenegativeregulationofsmallGTPasemediatedsignaltransductionnegativeregulationofsmoothmusclecellchemotaxisnegativeregulationofsmoothmusclecellmigrationnegativeregulationofvascularpermeabilitypositiveregulationofapoptoticprocesspositiveregulationofaxonogenesispulmonaryvalvemorphogenesisresponsetocortisolretinalganglioncellaxonguidanceRoundaboutsignalingpathwayuretericbuddevelopmentventricularseptummorphogenesis
Kallikrein-7
2.0
68
85
KLK7KLK7P49862P49862epidermisdevelopmentextracellularmatrixdisassemblypositiveregulationofantibacterialpeptideproductionproteolysis
Thioredoxin
2.0
61
88
✔
THIONFKB1P10599P19838activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiationapoptoticprocessBcellreceptorsignalingpathwaycellularresponsetoangiotensincellularresponsetodsRNAcellularresponsetointerleukin-1cellularresponsetointerleukin-17cellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetonicotinecellularresponsetotumornecrosisfactorcellularresponsetovirusinflammatoryresponseJNKcascademammaryglandinvolutionnegativeregulationofapoptoticprocessnegativeregulationofcalcidiol1-monooxygenaseactivitynegativeregulationofcholesteroltransportnegativeregulationofgeneexpressionnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-12productionnegativeregulationofproteinmetabolicprocessnegativeregulationofvitaminDbiosyntheticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationoflipidstoragepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmiRNAmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetomusclestretchtranscriptionbyRNApolymeraseII
IGH@ protein
2.0
nan
94
IGKCQ6GMX6P01834Q6GMX6adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasis
NKG2-D type II integral membrane protein
2.0
71
85
NKG2DNKG2DP26718P26718adaptiveimmuneresponsecelldifferentiationcellularresponsetolipopolysaccharidedefenseresponsetoGram-positivebacteriumnaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofGTPaseactivitynegativeregulationofnaturalkillercellchemotaxisnitricoxidebiosyntheticprocesspositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationoftypeIIinterferonproductionsignaltransductionstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulation
Gamma-aminobutyric acid receptor subunit gamma-2
2.0
73
85
A0A286YFI6A0A286YFI6A0A286YFI6A0A286YFI6gamma-aminobutyricacidsignalingpathway
Netrin receptor UNC5D
2.0
nan
90
UNC5DUNC5DF1LW30F1LW30apoptoticprocessaxonguidancecell-celladhesionviaplasma-membraneadhesionmoleculespyramidalneurondifferentiationregulationofneuronmigration
DnaJ homolog subfamily C member 3
2.0
69
85
DNJC3DNJC3Q91YW3Q91YW3cellularresponsetocoldendoplasmicreticulumunfoldedproteinresponsenegativeregulationofapoptoticprocessnegativeregulationofendoplasmicreticulumstress-inducedeIF2alphaphosphorylationnegativeregulationofproteinkinaseactivitypositiveregulationoftranslationinitiationinresponsetoendoplasmicreticulumstressproteinfoldinginendoplasmicreticulumproteolysisinvolvedinproteincatabolicprocessresponsetoendoplasmicreticulumstress
C-type lectin domain family 4 member E
2.0
49
86
E1BHM0E1BHM0E1BHM0E1BHM0antifungalinnateimmuneresponsedefenseresponsetobacteriumFc-gammareceptorsignalingpathwayimmuneresponsepatternrecognitionreceptorsignalingpathwaypositiveregulationofcytokineproductionTcelldifferentiationinvolvedinimmuneresponse
Oxidized low-density lipoprotein receptor 1
2.0
26
90
OLR1OLR1P78380P78380bloodcirculationcelldeathimmunesystemprocessinflammatoryresponseleukocytecell-celladhesionlipoproteinmetabolicprocessproteolysis
Platelet factor 4
2.0
53
86
PLF4PLF4P02776P02776adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoprotozoaninflammatoryresponsekillingbyhostofsymbiontcellskillingofcellsofanotherorganismleukocytechemotaxisnegativeregulationofangiogenesisnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofmegakaryocytedifferentiationnegativeregulationofMHCclassIIbiosyntheticprocessneutrophilchemotaxisplateletactivationpositiveregulationofgeneexpressionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellpopulationproliferation
C-type lectin domain family 4, member b1
2.0
56
84
Q9D8Q7Q9D8Q7Q9D8Q7Q9D8Q7antifungalinnateimmuneresponseimmuneresponsepositiveregulationofreleaseofsequesteredcalciumionintocytosol
Gamma-aminobutyric acid receptor subunit gamma-2
2.0
69
84
GBRG2GBRG2P18508P18508adultbehaviorcellularresponsetohistaminechemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticchloridetransmembranetransportchloridetransportgamma-aminobutyricacidsignalingpathwayinhibitorysynapseassemblyiontransmembranetransportnervoussystemprocesspost-embryonicdevelopmentregulationofmembranepotentialregulationofpostsynapticmembranepotentialsignaltransductionsynaptictransmissionGABAergic
HLA class I histocompatibility antigen, A alpha chain
2.0
75
82
✔
HLAAHLAAP04439P04439antibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-dependentantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-independentantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassICD8-positivealpha-betaTcellactivationdefenseresponsetoGram-positivebacteriumdetectionofbacteriumimmuneresponseinnateimmuneresponsepositiveregulationofCD8-positivealpha-betaTcellactivationpositiveregulationofCD8-positivealpha-betaTcellproliferationpositiveregulationofmemoryTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftypeIIinterferonproductionprotectionfromnaturalkillercellmediatedcytotoxicityTcellmediatedcytotoxicityTcellmediatedcytotoxicitydirectedagainsttumorcelltargetTcellreceptorsignalingpathway
Tyrosine-protein kinase CSK
2.0
53
83
✔
CSKCSKP41240P41240adaptiveimmuneresponseadherensjunctionorganizationbraindevelopmentcellularresponsetopeptidehormonestimulusnegativeregulationofboneresorptionnegativeregulationofcellpopulationproliferationnegativeregulationofERK1andERK2cascadenegativeregulationofGolgitoplasmamembraneproteintransportnegativeregulationofinterleukin-6productionnegativeregulationofkinaseactivitynegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationofphagocytosisoligodendrocytedifferentiationpositiveregulationofMAPkinaseactivityproteinautophosphorylationproteinphosphorylationregulationofFcreceptormediatedstimulatorysignalingpathwayTcellcostimulationTcellreceptorsignalingpathway
cDNA FLJ39643 fis, clone SMINT2004023, highly similar to HLA class I histocompatibility antigen, alphachain F
2.0
73
83
B3KUD8B3KUD8B3KUD8B3KUD8
Claudin-4
2.0
60
81
CLD4CLD4O14493O14493bicellulartightjunctionassemblycalcium-independentcell-celladhesionviaplasmamembranecell-adhesionmoleculescelladhesioncircadianrhythmestablishmentofskinbarrierfemalepregnancypositiveregulationofcellmigrationpositiveregulationofmetallopeptidaseactivitypositiveregulationofwoundhealingregulationofcellmorphogenesisrenalabsorptionresponsetoprogesterone
Nucleotide-binding oligomerization domain-containing protein 1
2.0
74
82
NOD1NOD1Q9Y239Q9Y239activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocesscellularresponsetomuramyldipeptidedefenseresponsedefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumdetectionofbacteriumdetectionofbioticstimulusERK1andERK2cascadeI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseintracellularsignaltransductionJNKcascadepatternrecognitionreceptorsignalingpathwaypositiveregulationofcelldeathpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofdendriticcellantigenprocessingandpresentationpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationoftumornecrosisfactorproductionpositiveregulationofxenophagyregulationofapoptoticprocesssignaltransductionxenophagy
Gamma-aminobutyric acid receptor subunit beta-1
2.0
67
82
GBRB1GBRB1P15431P15431cellularresponsetohistaminecentralnervoussystemneurondevelopmentchemicalsynaptictransmissionchloridetransmembranetransportchloridetransportGprotein-coupledreceptorsignalingpathwaygamma-aminobutyricacidsignalingpathwayiontransmembranetransportiontransportnervoussystemprocessovulationcycleregulationofmembranepotentialregulationofpresynapticmembranepotentialresponsetoprogesteroneresponsetotoxicsubstancesignaltransduction
Ras-related protein Rab-5C
2.0
56
85
RAB5CRAB5CP51148P51148endocytosisintracellularproteintransportplasmamembranetoendosometransportregulationofendocytosis
Glucocorticoid receptor
3.5
64
93
GCRGCRP06536P06536adrenalglanddevelopmentagingandrogenmetabolicprocessastrocytedifferentiationbraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetomagnesiumioncellularresponsetosteroidhormonestimuluscellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianrhythmfemalepregnancygeneexpressionglucocorticoidmediatedsignalingpathwayglucocorticoidmetabolicprocessglucocorticoidreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylungdevelopmentmammaryglandductmorphogenesismaternalbehaviormicrogliadifferentiationmotorbehaviormuscleatrophynegativeregulationofapoptoticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofsynapticplasticitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularpermeabilityneuroinflammatoryresponsepositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofglutamatesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofcellpopulationproliferationregulationofDNA-templatedtranscriptionregulationofglucocorticoidbiosyntheticprocessregulationofgluconeogenesisregulationofglucosemetabolicprocessregulationoftranscriptionbyRNApolymeraseIIresponsetoactivityresponsetoarsenic-containingsubstanceresponsetocalciumionresponsetocorticosteroneresponsetodexamethasoneresponsetoelectricalstimulusresponsetoinactivityresponsetoinsulinresponsetomercuryionresponsetoradiationsynaptictransmissionglutamatergictranscriptioninitiation-coupledchromatinremodeling
Semaphorin-4D
2.0
60
87
SEM4DSEM4DQ92854Q92854axonguidancecelladhesionimmuneresponseleukocyteaggregationnegativechemotaxisnegativeregulationofalkalinephosphataseactivitynegativeregulationofapoptoticprocessnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofcelladhesionnegativeregulationofosteoblastdifferentiationnegativeregulationofpeptidyl-tyrosinephosphorylationnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellmigrationossificationinvolvedinbonematurationpositiveregulationofcellmigrationpositiveregulationofcollateralsproutingpositiveregulationofGTPaseactivitypositiveregulationofinhibitorysynapseassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationregulationofcellprojectionorganizationregulationofcellshaperegulationofdendritemorphogenesissemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinbonetrabeculamorphogenesis
Melanocortin receptor 4
2.0
41
87
MC4RMC4RP32245P32245adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaydietinducedthermogenesisenergyreservemetabolicprocessfeedingbehaviorinsulinsecretionnegativeregulationoffeedingbehaviorpositiveregulationofboneresorptionregulationofeatingbehaviorregulationofgroomingbehaviorregulationofmetabolicprocessresponsetoinsulinresponsetomelanocyte-stimulatinghormone
Interleukin-22
2.0
63
83
IL22IL22Q9GZX6Q9GZX6acute-phaseresponseinflammatoryresponseresponsetoglucocorticoid
Centrosomal protein of 135 kDa
2.0
48
85
CP135CP135Q66GS9Q66GS9centriolereplicationcentriole-centriolecohesionpositiveregulationofestablishmentofproteinlocalizationpositiveregulationofnon-motileciliumassembly
Free fatty acid receptor 1
2.0
72
84
FFAR1FFAR1O14842O14842Gprotein-coupledreceptorsignalingpathwayglucosehomeostasisinsulinsecretionionchannelmodulatingGprotein-coupledreceptorsignalingpathwayligand-gatedionchannelsignalingpathwaynegativeregulationofinterleukin-1betaproductionphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcalciumiontransportpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofinsulinsecretionresponsetofattyacid
Follicle-stimulating hormone receptor
2.1
nan
92
FSHRFSHRP23945P23945activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetofollicle-stimulatinghormonestimulusfemalegametegenerationfemalegonaddevelopmentfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorsignalingpathwaygonaddevelopmenthormone-mediatedsignalingpathwaymalegonaddevelopmentpositiveregulationofERK1andERK2cascadepositiveregulationofphosphatidylinositol3-kinasesignalingregulationofproteinkinaseAsignalingspermatogenesis
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
2.1
65
86
Q9TTF5Q9TTF5Q9TTF5Q9TTF5metabolicprocess
C-C motif chemokine 27
2.0
48
83
CCL27CCL27Q9Y4X3Q9Y4X3antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingchemotaxisimmuneresponsekillingofcellsofanotherorganismpositiveregulationofactincytoskeletonreorganization
Platelet-derived growth factor receptor beta
2.0
75
81
PGFRBPGFRBP09619P09619agingangiogenesisaortamorphogenesiscardiacmyofibrilassemblycellchemotaxiscellmigrationcellmigrationinvolvedincoronaryangiogenesiscellmigrationinvolvedinvasculogenesisglycosaminoglycanbiosyntheticprocessinnereardevelopmentlunggrowthmalegonaddevelopmentmetanephriccomma-shapedbodymorphogenesismetanephricglomerularcapillaryformationmetanephricglomerularmesangialcellproliferationinvolvedinmetanephrosdevelopmentmetanephricmesenchymalcellmigrationmetanephricmesenchymedevelopmentmetanephricS-shapedbodymorphogenesisnegativeregulationofapoptoticprocesspeptidyl-tyrosinephosphorylationphosphatidylinositolmetabolicprocessphosphatidylinositol-mediatedsignalingplatelet-derivedgrowthfactorreceptorsignalingpathwayplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofcalciumionimportpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationbyVEGF-activatedplateletderivedgrowthfactorreceptorsignalingpathwaypositiveregulationofchemotaxispositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNAbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofhepaticstellatecellactivationpositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmetanephricmesenchymalcellmigrationbyplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofmitoticnucleardivisionpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivitypositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofRhoproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationproteinautophosphorylationregulationofactincytoskeletonorganizationresponsetoestradiolresponsetoestrogenresponsetofluidshearstressresponsetohydrogenperoxideresponsetohyperoxiaresponsetoretinoicacidresponsetotoxicsubstanceretinavasculaturedevelopmentincamera-typeeyesignaltransductionsmoothmusclecellchemotaxistransmembranereceptorproteintyrosinekinasesignalingpathwaywoundhealing
Fc epsilon receptor II
2.0
nan
94
E1BIQ4E1BIQ4E1BIQ4E1BIQ4positiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocess
Macrophage colony-stimulating factor 1
2.0
61
88
CSF1CSF1P09603P09603branchinginvolvedinmammaryglandductmorphogenesiscellularresponsetoparathyroidhormonestimulusdevelopmentalprocessinvolvedinreproductionhomeostasisofnumberofcellswithinatissueinflammatoryresponseinnateimmuneresponsemacrophagecolony-stimulatingfactorsignalingpathwaymacrophagedifferentiationmacrophagehomeostasismammaryductterminalendbudgrowthmammaryglandfatdevelopmentmicroglialcellproliferationmonocyteactivationmonocytedifferentiationmonocytehomeostasismyeloidleukocytemigrationnegativeregulationofneurondeathneutrophilhomeostasisodontogenesisossificationosteoclastdifferentiationosteoclastproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofmacrophagechemotaxispositiveregulationofmacrophagecolony-stimulatingfactorsignalingpathwaypositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmacrophagedifferentiationpositiveregulationofmacrophagemigrationpositiveregulationofmacrophageproliferationpositiveregulationofmicroglialcellmigrationpositiveregulationofmonocytedifferentiationpositiveregulationofmononuclearcellmigrationpositiveregulationofmononuclearcellproliferationpositiveregulationofmulticellularorganismgrowthpositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofosteoclastdifferentiationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinmetabolicprocesspositiveregulationofRasproteinsignaltransductionRasproteinsignaltransductionregulationofmacrophagederivedfoamcelldifferentiationregulationofossificationresponsetoischemiaresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetoorganiccycliccompoundtransmembranereceptorproteintyrosinekinasesignalingpathway
Allograft inflammatory factor 1-like
2.0
60
81
AIF1LAIF1LQ9BQI0Q9BQI0actinfilamentbundleassemblyruffleassembly
Cystatin-C
2.0
38
90
CYTCCYTCP01034P01034defenseresponsenegativeregulationofbloodvesselremodelingnegativeregulationofcollagencatabolicprocessnegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationofelastincatabolicprocessnegativeregulationofextracellularmatrixdisassemblynegativeregulationofpeptidaseactivitynegativeregulationofproteolysisregulationoftissueremodelingsupramolecularfiberorganization
P2Y purinoceptor 1
2.1
46
89
P2RY1P2RY1P47900P47900adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayagingbloodvesseldiametermaintenancecellsurfacereceptorsignalingpathwaycellularresponsetoATPcellularresponsetopurine-containingcompoundeatingbehaviorestablishmentoflocalizationincellGprotein-coupledadenosinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayglialcellmigrationiontransportnegativeregulationofbindingnegativeregulationofnorepinephrinesecretionphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayplateletactivationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofhormonesecretionpositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofiontransportpositiveregulationofpenileerectionpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtoplasmamembraneregulationofcellshaperegulationofpresynapticcytosoliccalciumionconcentrationregulationofsignalingreceptoractivityregulationofsynapticvesicleexocytosisrelaxationofmuscleresponsetogrowthfactorresponsetomechanicalstimulussensoryperceptionofpainsignaltransductioninvolvedinregulationofgeneexpression
SH2B adapter protein 3
2.0
32
86
SH2B3SH2B3O09039O09039cellularresponsetochemokinecellularresponsetointerleukin-3embryonichemopoiesiserythrocytedevelopmenthematopoieticstemcelldifferentiationhemopoiesisintracellularsignaltransductionmegakaryocytedevelopmentmonocytehomeostasisnegativeregulationofcellpopulationproliferationnegativeregulationofchemokine-mediatedsignalingpathwaynegativeregulationofKitsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofplateletaggregationnegativeregulationofproteinkinaseBsignalingnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofresponsetocytokinestimulusnegativeregulationofsproutingangiogenesisnegativeregulationoftyrosinephosphorylationofSTATproteinneutrophilhomeostasisregulationofregulatoryTcelldifferentiationthrombopoietin-mediatedsignalingpathway
Reticulon-4 receptor
2.0
nan
90
RTN4RRTN4RQ9BZR6Q9BZR6axonogenesiscellsurfacereceptorsignalingpathwaycorpuscallosumdevelopmentnegativeregulationofaxonextensionnegativeregulationofaxonregenerationnegativeregulationofneuronprojectiondevelopmentneuronalsignaltransductionpositiveregulationofGTPaseactivitypositiveregulationofRhoproteinsignaltransduction
Neurexophilin-1
2.0
24
89
NXPH1NXPH1Q63366Q63366
Coagulation factor VII
2.0
nan
92
FA7FA7P08709P08709activationofbloodcoagulationviaclottingcascadeanimalorganregenerationbloodcoagulationbloodcoagulationextrinsicpathwaybloodcoagulationfibrinclotformationbloodcoagulationintrinsicpathwaycircadianrhythmpositiveregulationofbloodcoagulationpositiveregulationofcellmigrationpositiveregulationofleukocytechemotaxispositiveregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofpositivechemotaxispositiveregulationofproteinkinaseBsignalingproteinprocessingproteolysisresponseto2378-tetrachlorodibenzodioxineresponsetoanticoagulantresponsetoastaxanthinresponsetocarbondioxideresponsetocholesterolresponsetoestradiolresponsetoestrogenresponsetogenisteinresponsetogrowthhormoneresponsetohypoxiaresponsetoThyroidstimulatinghormoneresponsetothyrotropin-releasinghormoneresponsetothyroxineresponsetovitaminKresponsetowoundingzymogenactivation
Low affinity immunoglobulin gamma Fc region receptor III-A
2.0
83
84
FCG3AFCG3AP08637P08637antibody-dependentcellularcytotoxicitycalcium-mediatedsignalingcellsurfacereceptorsignalingpathwayFc-gammareceptorsignalingpathwayimmuneresponsemacrophageactivationnaturalkillercellactivationnaturalkillercelldegranulationnaturalkillercellmediatedcytotoxicityphosphatidylinositol3-kinasesignalingpositiveregulationofnaturalkillercellproliferationpositiveregulationoftumornecrosisfactorproductionregulationofimmuneresponse
Kelch-like ECH-associated protein 1
2.0
54
84
KEAP1KEAP1Q14145Q14145cellularresponsetointerleukin-4cellularresponsetooxidativestresscytoplasmicsequesteringoftranscriptionfactorinuteroembryonicdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofautophagyregulationofepidermalcelldifferentiationubiquitin-dependentproteincatabolicprocess
G-protein coupled receptor 35
2.0
67
85
GPR35GPR35Q9HC97Q9HC97chemokine-mediatedsignalingpathwaycytoskeletonorganizationGprotein-coupledreceptorsignalingpathwaynegativeregulationofneuronalactionpotentialnegativeregulationofvoltage-gatedcalciumchannelactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofRhoproteinsignaltransduction
Interferon beta
2.0
53
85
IFNBIFNBP01574P01574adaptiveimmuneresponseBcellactivationinvolvedinimmuneresponseBcelldifferentiationBcellproliferationcellsurfacereceptorsignalingpathwaycellularresponsetoexogenousdsRNAcellularresponsetointerferon-betacellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirushumoralimmuneresponsenaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofLewybodyformationnegativeregulationofTcelldifferentiationnegativeregulationofT-helper2cellcytokineproductionnegativeregulationofviralgenomereplicationneuroncellularhomeostasispositiveregulationofapoptoticsignalingpathwaypositiveregulationofautophagypositiveregulationofinnateimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationofSTATproteinpositiveregulationoftranscriptionbyRNApolymeraseIIreceptorsignalingpathwayviaJAK-STATregulationofMHCclassIbiosyntheticprocessresponsetoexogenousdsRNAresponsetovirusTcellactivationinvolvedinimmuneresponsetypeIinterferon-mediatedsignalingpathway
HLA class II histocompatibility antigen DQ alpha chain
2.0
79
79
Q08AS3Q08AS3Q08AS3Q08AS3adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
MHC class I antigen
2.0
82
82
S6BVK3S6BVK3S6BVK3S6BVK3antigenprocessingandpresentationimmuneresponse
Adhesion G protein-coupled receptor E5
2.0
57
88
AGRE5AGRE5P48960P48960adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycelladhesioncellsurfacereceptorsignalingpathwaycell-cellsignalingGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponse
Cholesteryl ester transfer protein
2.0
61
84
CETPCETPP11597P11597cholesterolhomeostasischolesterolmetabolicprocesscholesteroltransporthigh-densitylipoproteinparticleremodelinglipidhomeostasislipidtransportlow-densitylipoproteinparticleremodelingnegativeregulationofmacrophagederivedfoamcelldifferentiationphosphatidylcholinemetabolicprocessphospholipidhomeostasispositiveregulationofcholesteroltransportpositiveregulationofphospholipidtransportregulationofcholesteroleffluxreversecholesteroltransporttriglyceridehomeostasistriglyceridemetabolicprocesstriglyceridetransportvery-low-densitylipoproteinparticleremodeling
Transformation/transcription domain-associated protein
2.0
53
87
✔
TRRAPTRRAPQ9Y4A5Q9Y4A5chromatinorganizationDNArepairhistoneacetylationhistoneH2AacetylationhistoneH3acetylationhistoneH4acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofapoptoticprocessregulationofcellcycleregulationofDNArepairregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseII
Inter-alpha-trypsin inhibitor heavy chain H1
2.0
30
85
ITIH1ITIH1P19827P19827hyaluronanmetabolicprocessnegativeregulationofpeptidaseactivity
HLA class II histocompatibility antigen, DO alpha chain
2.0
83
78
DOADOAP06340P06340adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIInegativeregulationofantigenprocessingandpresentationofpeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationregulationofTcelldifferentiation
Eukaryotic translation initiation factor 5A-1
2.0
44
87
IF5A1IF5A1P63241P63241cellularresponsetoviruspositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationalelongationpositiveregulationoftranslationalterminationtranslationalelongationtumornecrosisfactor-mediatedsignalingpathway
Neurogenic locus notch homolog protein 3
2.0
nan
90
NOTC3NOTC3Q9UM47Q9UM47arterymorphogenesisaxonguidanceforebraindevelopmentglomerularcapillaryformationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIneuroblastdifferentiationneuronfatecommitmentNotchsignalingpathwaypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseII
HLA-B alpha chain (B*5703GB)
2.0
83
82
I3ZN84I3ZN84I3ZN84I3ZN84antigenprocessingandpresentationimmuneresponse
Hepcidin
2.1
53
82
HEPCHEPCP81172P81172acute-phaseresponseagingantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularironionhomeostasiscellularresponsetobileacidcellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcellularresponsetoX-raydefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellimmuneresponseironiontransmembranetransportkillingofcellsofanotherorganismliverregenerationmacrophageactivationmulticellularorganismalironionhomeostasismyeloidcellhomeostasisnegativeregulationofboneresorptionnegativeregulationofinflammatoryresponsenegativeregulationofintestinalabsorptionnegativeregulationofiontransmembranetransporteractivitynegativeregulationofironexportacrossplasmamembranenegativeregulationofironiontransmembranetransportnegativeregulationofironiontransmembranetransporteractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofmacrophageactivationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinpolyubiquitinationpositiveregulationofreceptorcatabolicprocesspositiveregulationofreceptorinternalizationpositiveregulationoftranscriptionbyRNApolymeraseIIproteincatabolicprocessreceptorsignalingpathwayviaJAK-STATresponsetoerythropoietinresponsetoethanolresponsetoironionresponsetoironionstarvationresponsetovitaminAresponsetozinciontranscriptionbyRNApolymeraseII
Ficolin-1
2.0
35
90
FCN1FCN1O00602O00602cellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationlectinpathwayGprotein-coupledreceptorsignalingpathwaynegativeregulationofviralentryintohostcellpositiveregulationofinterleukin-8productionpositiveregulationofopsonizationproteinlocalizationtocellsurfaceproteolysisrecognitionofapoptoticcell
Leukocyte tyrosine kinase receptor
2.0
86
81
LTKLTKP29376P29376cellpopulationproliferationcellularresponsetoretinoicacidnegativeregulationofapoptoticprocesspeptidyl-tyrosineautophosphorylationphosphatidylinositol3-kinasesignalingpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofkinaseactivitypositiveregulationofneuronprojectiondevelopmentproteinphosphorylationregulationofcellpopulationproliferationregulationofneurondifferentiationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Hairy/enhancer-of-split related with YRPW motif protein 1
2.0
77
82
HEY1HEY1Q9Y5J3Q9Y5J3angiogenesisanterior/posteriorpatternspecificationaorticvalvemorphogenesisarterialendothelialcelldifferentiationatrioventricularvalveformationcardiacconductionsystemdevelopmentcardiacepithelialtomesenchymaltransitioncardiacseptummorphogenesiscardiacventriclemorphogenesiscirculatorysystemdevelopmentdorsalaortamorphogenesisendocardialcushionmorphogenesishearttrabeculaformationlabyrinthinelayerbloodvesseldevelopmentnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofDNA-templatedtranscriptionnegativeregulationofneurondifferentiationnegativeregulationofNotchsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedinsmoothmusclecelldifferentiationnegativeregulationoftranscriptionregulatoryregionDNAbindingNotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpulmonaryvalvemorphogenesisregulationofneurogenesisregulationoftranscriptionbyRNApolymeraseIIregulationofvasculogenesisumbilicalcordmorphogenesisventricularseptummorphogenesis
Xylosyltransferase 1
2.0
57
88
XYLT1XYLT1Q86Y38Q86Y38chondroitinsulfatebiosyntheticprocesschondroitinsulfateproteoglycanbiosyntheticprocessembryonicskeletalsystemdevelopmentglycosaminoglycanbiosyntheticprocessglycosaminoglycanmetabolicprocessheparansulfateproteoglycanbiosyntheticprocessossificationinvolvedinbonematurationproteoglycanbiosyntheticprocess
CD81 antigen
2.0
76
81
CD81CD81P60033P60033CD4-positivealpha-betaTcellcostimulationcellularresponsetolow-densitylipoproteinparticlestimulushumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunologicalsynapseformationmacrophagefusionmyoblastfusioninvolvedinskeletalmuscleregenerationosteoclastfusionpositiveregulationof1-phosphatidylinositol4-kinaseactivitypositiveregulationofadaptiveimmunememoryresponsepositiveregulationofBcellproliferationpositiveregulationofBcellreceptorsignalingpathwaypositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofinflammatoryresponsetoantigenicstimuluspositiveregulationofMAPKcascadepositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteincatabolicprocessinthevacuolepositiveregulationofproteinexitfromendoplasmicreticulumpositiveregulationofreceptorclusteringpositiveregulationofTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcellpositiveregulationofTcellreceptorsignalingpathwaypositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationproteinlocalizationtolysosomeproteinlocalizationtoplasmamembranereceptorinternalizationreceptor-mediatedvirionattachmenttohostcellregulationofmacrophagemigrationregulationofproteinstabilityviralentryintohostcell
Aminopeptidase
2.0
70
83
K7GMF9K7GMF9K7GMF9K7GMF9peptidecatabolicprocessproteolysisregulationofbloodpressuresignaltransduction
Ig-like domain-containing protein
2.1
nan
94
V9HW68Q7Z3Y4V9HW68Q7Z3Y4
C-type lectin domain family 4 member K
2.0
76
81
CLC4KCLC4KQ9UJ71Q9UJ71defenseresponsetovirus
T cell receptor beta constant 1
2.1
83
78
K7N5N2TRBC1K7N5M9P01850adaptiveimmuneresponsealpha-betaTcellactivationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationTcellreceptorsignalingpathway
Immunoglobulin heavy constant gamma 1
2.0
nan
94
IGHG1IGHG1P01857P01857adaptiveimmuneresponseantibody-dependentcellularcytotoxicityBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaycomplement-dependentcytotoxicitydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Neuregulin 1
2.1
59
86
Q96IB3Q96IB3Q96IB3Q96IB3nervoussystemdevelopment
Aminopeptidase N
2.0
71
83
AMPNAMPNP15144P15144angiogenesiscelldifferentiationpeptidecatabolicprocessproteolysisregulationofbloodpressuresignaltransduction
Cerebral dopamine neurotrophic factor
2.0
41
91
CDNFCDNFQ49AH0Q49AH0dopaminergicneurondifferentiationneuronprojectiondevelopment
Integrin beta-3
2.0
42
89
ITA2BITB3P08514P05106angiogenesiscelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionintegrin-mediatedsignalingpathwayactivationofproteinkinaseactivityangiogenesisinvolvedinwoundhealingapolipoproteinA-I-mediatedsignalingpathwayapoptoticcellclearancebloodcoagulationcelladhesioncellmigrationcell-substrateadhesioncell-substratejunctionassemblycellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoxenobioticstimulusembryoimplantationheterotypiccell-celladhesionmaintenanceofpostsynapticspecializationstructuremesodermalcelldifferentiationnegativechemotaxisnegativeregulationofcelldeathnegativeregulationoflipidstoragenegativeregulationoflipidtransportnegativeregulationoflipoproteinmetabolicprocessnegativeregulationoflow-densitylipoproteinreceptoractivitynegativeregulationofmacrophagederivedfoamcelldifferentiationplateletactivationplateletaggregationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofadenylatecyclase-inhibitingopioidreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofboneresorptionpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofactincytoskeletonorganizationregulationofboneresorptionregulationofextracellularmatrixorganizationregulationofpostsynapticneurotransmitterreceptordiffusiontrappingregulationofpostsynapticneurotransmitterreceptorinternalizationregulationofproteinlocalizationregulationofproteintyrosinekinaseactivityregulationofreleaseofsequesteredcalciumionintocytosolregulationofserotoninuptakeregulationoftrophoblastcellmigrationresponsetoactivityresponsetoradiationsmoothmusclecellmigrationsubstrateadhesion-dependentcellspreadingtubedevelopmentviralentryintohostcellwoundhealing
Ephrin type-A receptor 4
2.0
68
88
EPHA4EPHA4P54764P54764adherensjunctionorganizationadultwalkingbehavioraxonguidancecelladhesioncellularresponsetoamyloid-betacochleadevelopmentcorticospinaltractmorphogenesisephrinreceptorsignalingpathwayfasciculationofmotorneuronaxonfasciculationofsensoryneuronaxonglialcellmigrationmotorneuronaxonguidancenegativeregulationofaxonregenerationnegativeregulationofcelladhesionnegativeregulationofcellmigrationnegativeregulationofcellularresponsetohypoxianegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofERK1andERK2cascadenegativeregulationoflong-termsynapticpotentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofproteolysisinvolvedinproteincatabolicprocessnephricductmorphogenesisneuronprojectionfasciculationneuronprojectionguidancepeptidyl-tyrosinephosphorylationpositiveregulationofamyloid-betaformationpositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofdendritemorphogenesispositiveregulationofJUNkinaseactivitypositiveregulationofkinaseactivitypositiveregulationofproteintyrosinekinaseactivitypositiveregulationofRhoguanyl-nucleotideexchangefactoractivityproteinautophosphorylationproteinstabilizationregulationofastrocytedifferentiationregulationofaxonogenesisregulationofdendriticspinemorphogenesisregulationofGTPaseactivityregulationofmodificationofsynapticstructureregulationofsynapsepruningsynapsepruningtransmembranereceptorproteintyrosinekinasesignalingpathway
Insulin-like growth factor-binding protein 2
2.0
51
87
IBP2IBP2P18065P18065agingcellularresponsetohormonestimulusfemalepregnancynegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofactivatedTcellproliferationregulationofinsulin-likegrowthfactorreceptorsignalingpathwayresponsetoestradiolresponsetoestrogenresponsetoglucocorticoidresponsetolithiumionresponsetomechanicalstimulusresponsetonutrientresponsetoretinoicacidresponsetoxenobioticstimulussignaltransduction
Immunoglobulin kappa constant
2.0
nan
94
IGKCQ6GMX6P01834Q6GMX6adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasis
Frizzled-8
2.0
57
85
FZD8FZD8Q61091Q61091angiogenesiscanonicalWntsignalingpathwaypositiveregulationofJUNkinaseactivitypositiveregulationofproteinphosphorylationTcelldifferentiationinthymusWntsignalingpathway
IGL@ protein
2.0
86
81
Q567P1Q567P1Q567P1Q567P1
Secreted frizzled-related protein 3
2.0
54
85
SFRP3SFRP3P97401P97401canonicalWntsignalingpathwaycochleamorphogenesisconvergentextensioninvolvedinorganogenesisepithelialcelldevelopmenthepatocytedifferentiationinnerearmorphogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcartilagedevelopmentnegativeregulationofcelldevelopmentnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofhepatocytedifferentiationnegativeregulationofWntsignalingpathwayneuralcrestcelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationoffatcelldifferentiationsomitedevelopment
Interleukin-20 receptor subunit beta
2.0
68
86
I20RBI20RBQ6UXL0Q6UXL0cytokine-mediatedsignalingpathwayhomeostasisofnumberofcellswithinatissueimmuneresponse-inhibitingsignaltransductioninflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-2productionnegativeregulationofTcellproliferationnegativeregulationoftypeIIinterferonproductionnegativeregulationoftypeIVhypersensitivitypositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-4productionTcellhomeostasisTcellproliferation
Beta-galactoside alpha-2,6-sialyltransferase 1
2.0
42
86
SIAT1SIAT1P15907P15907humoralimmuneresponseN-acetylneuraminatemetabolicprocessnegativeregulationofchemotaxisnegativeregulationofmacrophageapoptoticprocessO-glycanprocessingpositiveregulationofmononuclearcellproliferationproteinN-linkedglycosylationviaasparagineproteinsialylationregulationofsubstrateadhesion-dependentcellspreadingresponsetoethanolsialylationviralproteinprocessing
Immunoglobulin heavy constant gamma 2
2.0
80
80
IGHG2IGHG2P01859P01859adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
MHC class I antigen
2.0
80
82
Q861F7Q861F7Q861F7Q861F7antigenprocessingandpresentationimmuneresponse
MHC class II antigen
2.0
79
80
A9JJF6A9JJF6A9JJF6A9JJF6adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Mediator of RNA polymerase II transcription subunit 28
2.0
80
81
MED28MED28Q920D3Q920D3negativeregulationofsmoothmusclecelldifferentiationpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblysomaticstemcellpopulationmaintenance
Marginal zone B- and B1-cell-specific protein
2.0
52
84
MZB1MZB1Q8WU39Q8WU39apoptoticprocessintegrinactivationpositiveregulationofcellpopulationproliferationpositiveregulationofimmunoglobulinproductionregulationofBcellproliferationregulationofcellpopulationproliferationregulationofinsulinreceptorsignalingpathway
Forkhead box protein L2
2.0
36
87
FOXL2FOXL2P58012P58012anatomicalstructuremorphogenesisapoptoticDNAfragmentationcelldifferentiationembryoniceyemorphogenesisextraocularskeletalmuscledevelopmentfemalesomaticsexdeterminationgranulosacelldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIoocytegrowthovarianfollicledevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofluteinizinghormonesecretionregulationoftranscriptionbyRNApolymeraseIIsinglefertilizationuterusdevelopment
Sodium/potassium-transporting ATPase subunit beta
2.0
58
84
G3MWR4G3MWR4G3MWR4G3MWR4ATPmetabolicprocesscardiacmusclecontractioncelladhesioncellularcalciumionhomeostasiscellularpotassiumionhomeostasiscellularsodiumionhomeostasismembranerepolarizationpositiveregulationofcalciumpositiveregulationofP-typesodiumpositiveregulationofpotassiumionimportacrossplasmamembranepositiveregulationofsodiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembraneproteinlocalizationtoplasmamembraneproteinstabilizationregulationofcardiacmusclecontractionbycalciumionsignalingregulationofgeneexpressionrelaxationofcardiacmusclesodiumionexportacrossplasmamembrane
Chymase
2.0
71
84
CMA1CMA1P23946P23946angiotensinmaturationbasementmembranedisassemblycellularresponsetoglucosestimuluscytokineprecursorprocessingextracellularmatrixdisassemblymidbraindevelopmentpositiveregulationofangiogenesisproteincatabolicprocessregulationofinflammatoryresponse
Toll-like receptor 9
2.0
45
88
TLR9TLR9Q9EQU3Q9EQU3activationofinnateimmuneresponsecellularresponsetochloroquinecellularresponsetolipopolysaccharidecellularresponsetometaliondefenseresponsetoGram-negativebacteriumdefenseresponsetovirusI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationimmuneresponseinnateimmuneresponsemaintenanceofgastrointestinalepitheliummalegonaddevelopmentmicroglialcellactivationMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofERK1andERK2cascadenegativeregulationofinterleukin-6productionnegativeregulationofinterleukin-8productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftoll-likereceptorsignalingpathwaypositiveregulationofautophagypositiveregulationofBcellactivationpositiveregulationofBcellproliferationpositiveregulationofchemokineproductionpositiveregulationofcytokineproductionpositiveregulationofgeneexpressionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofimmunoglobulinproductionpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-18productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationoftoll-likereceptor9signalingpathwaypositiveregulationoftoll-likereceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionregulationofBcellactivationregulationofBcelldifferentiationregulationofdendriticcellcytokineproductionregulationofinflammatoryresponseregulationofproteinphosphorylationregulationoftoll-likereceptor9signalingpathwayresponsetomoleculeofbacterialoriginresponsetovirustoll-likereceptorsignalingpathway
Norrin
2.0
44
91
NDPNDPQ00604Q00604decidualizationextracellularmatrix-cellsignalingnervoussystemdevelopmentNorrinsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionretinavasculaturemorphogenesisincamera-typeeyevacuoleorganizationvisualperceptionWntsignalingpathway
MHC class II HLA-DQ-beta-1
2.0
79
80
O19707O19707O19707O19707adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Interleukin-21
2.0
51
87
IL21IL21Q9HBE4Q9HBE4cellmaturationcellularresponsetovirusdefenseresponsetovirusgerminalcenterBcelldifferentiationpositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofimmunoglobulinproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationoftissueremodelingpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinsignaltransductionTfollicularhelpercelldifferentiationtyrosinephosphorylationofSTATprotein
Phospholipase A2 group XV
2.0
64
83
PAG15PAG15Q8NCC3Q8NCC3ceramidemetabolicprocessdiacylglycerolbiosyntheticprocessfattyacidcatabolicprocessglycerophospholipidmetabolicprocesslipidmetabolicprocessphosphatidylcholinecatabolicprocessphosphatidylcholinemetabolicprocessphosphatidylethanolaminecatabolicprocessphosphatidylglycerolmetabolicprocessphosphatidylserinemetabolicprocessphospholipidmetabolicprocess
Protein FAM3C
2.6
56
88
FAM3CFAM3CQ92520Q92520
Cathepsin S
2.0
66
86
CATSCATSP25774P25774adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigenbasementmembranedisassemblycellularresponsetothyroidhormonestimuluscollagencatabolicprocessextracellularmatrixdisassemblyimmuneresponsepositiveregulationofcationchannelactivityproteinprocessingproteolysisproteolysisinvolvedinproteincatabolicprocessresponsetoacidicpHtoll-likereceptorsignalingpathway
Adenosine receptor A2a
2.0
29
90
AA2ARAA2ARP29274P29274adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayapoptoticprocessapoptoticsignalingpathwayastrocyteactivationbloodcirculationbloodcoagulationcell-cellsignalingcellulardefenseresponsecentralnervoussystemdevelopmenteatingbehaviorexcitatorypostsynapticpotentialGprotein-coupledadenosinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponseinhibitorypostsynapticpotentiallocomotorybehaviormembranedepolarizationnegativeregulationofalpha-betaTcellactivationnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofinflammatoryresponsenegativeregulationoflocomotionnegativeregulationofneuronapoptoticprocessnegativeregulationofproteinkinaseactivitynegativeregulationofvascularpermeabilityneuronprojectionmorphogenesisphagocytosispositiveregulationofacetylcholinesecretionneurotransmissionpositiveregulationofapoptoticsignalingpathwaypositiveregulationofcircadiansleep/wakecyclesleeppositiveregulationofglutamatesecretionpositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinsecretionpositiveregulationofrenalsodiumexcretionpositiveregulationofsynaptictransmissionGABAergicpositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofurinevolumeprepulseinhibitionpresynapticmodulationofchemicalsynaptictransmissionproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofcalciumiontransportregulationofDNA-templatedtranscriptionregulationofmitochondrialmembranepotentialregulationofnorepinephrinesecretionresponsetoamphetamineresponsetocaffeineresponsetoinorganicsubstanceresponsetopurine-containingcompoundresponsetoxenobioticstimulussensoryperceptionsynaptictransmissioncholinergicsynaptictransmissiondopaminergicsynaptictransmissionglutamatergicvasodilation
MHC class I antigen
2.0
82
82
A0A125R585A0A125R585A0A125R585A0A125R585antigenprocessingandpresentationimmuneresponse
Peptidoglycan recognition protein 4
2.0
nan
89
PGRP4PGRP4Q3B822Q3B822antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-positivebacteriumdetectionofbacteriuminnateimmuneresponsekillingofcellsofanotherorganismpeptidoglycancatabolicprocess
V-set and immunoglobulin domain containing 4
2.0
87
78
F6TUL9F6TUL9F6TUL9F6TUL9negativeregulationofcomplementactivationalternativepathwaynegativeregulationofinterleukin-2productionnegativeregulationofmacrophageactivationnegativeregulationofTcellproliferation
Complement factor D
2.0
64
85
CFADCFADP00746P00746complementactivationcomplementactivationalternativepathwayproteolysisresponsetobacterium
P2X purinoceptor 3
2.0
60
87
P2RX3P2RX3P56373P56373behavioralresponsetoformalininducedpaincellularresponsetoATPestablishmentoflocalizationincellinorganiccationtransmembranetransportneuromuscularsynaptictransmissionneuronalactionpotentialperistalsispositiveregulationofcalciumiontransportintocytosolpositiveregulationofcalcium-mediatedsignalingpositiveregulationofsensoryperceptionofpainproteinhomotrimerizationregulationofsynapticplasticityresponsetocarbohydrateresponsetocoldresponsetoheatresponsetohypoxiaresponsetomechanicalstimulussensoryperceptionoftastesignaltransductionurinarybladdersmoothmusclecontraction
Mitochondrial import inner membrane translocase subunit Tim9
2.0
64
82
TIM9TIM9Q9Y5J7Q9Y5J7proteininsertionintomitochondrialinnermembraneproteintargetingtomitochondrionsensoryperceptionofsound
KIR3DL1
2.0
86
81
I6LEL9I6LEL9I6LEL9I6LEL9
Transmembrane prolyl 4-hydroxylase
2.0
70
84
P4HTMP4HTMQ9NXG6Q9NXG6peptidyl-prolinehydroxylationto4-hydroxy-L-prolineregulationoferythrocytedifferentiation
Immunoglobulin lambda constant 2
2.1
93
81
IGLC2IGLC2P0DOY2P0DOY2BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
T-cell surface protein tactile
2.0
47
87
TACTTACTP40200P40200celladhesioncell-matrixadhesionimmuneresponseinflammatoryresponsenegativeregulationofnaturalkillercellcytokineproductionnegativeregulationoftypeIIinterferonproductionresponsetolipopolysaccharide
Immunoglobulin lambda-like polypeptide 1
2.0
87
78
IGLL1IGLL1P15814P15814BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Prostaglandin G/H synthase 1
2.0
62
87
PGH1PGH1P05979P05979cyclooxygenasepathwayprostaglandinbiosyntheticprocessregulationofbloodpressureresponsetooxidativestress
CD70 antigen
2.0
78
80
CD70CD70P32970P32970BcellmediatedimmunityBcellproliferationcell-cellsignalingextrinsicapoptoticsignalingpathwaypositiveregulationofTcellproliferationsignaltransductionTcellmediatedimmunitytumornecrosisfactor-mediatedsignalingpathway
Ig-like domain-containing protein
2.0
77
80
Q31164Q31164Q31164Q31164adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassII
Glutamate receptor ionotropic, delta-2
2.0
nan
91
GRID2GRID2Q63226Q63226cerebellargranulecelldifferentiationexcitatorypostsynapticpotentialexcitatorysynapseassemblyheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesmodulationofchemicalsynaptictransmissionpositiveregulationoflong-termsynapticdepressionpositiveregulationofsynapseassemblyprepulseinhibitionproteinlocalizationregulationofneuronapoptoticprocessregulationofneuronprojectiondevelopmentregulationofpostsynapticdensityassemblyregulationofpresynapseassemblysynaptictransmissionglutamatergic
Tryptase beta-2
2.0
68
83
TRYB2TRYB2P20231P20231proteolysis
5'-nucleotidase
2.0
39
87
5NTD5NTDP21589P21589adenosinebiosyntheticprocessADPcatabolicprocessAMPcatabolicprocessATPmetabolicprocesscalciumionhomeostasisDNAmetabolicprocessleukocytecell-celladhesionnegativeregulationofinflammatoryresponseresponsetoATPresponsetoinorganicsubstance
T-cell surface glycoprotein CD4
3.8
35
90
CD4LCKP01730P06239adaptiveimmuneresponsecalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimulusdefenseresponsetoGram-negativebacteriumenzyme-linkedreceptorproteinsignalingpathwayhelperTcellenhancementofadaptiveimmuneresponseimmuneresponseinterleukin-15-mediatedsignalingpathwaymacrophagedifferentiationmaintenanceofproteinlocationincellpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmonocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofTcellactivationpositiveregulationofviralentryintohostcellregulationofcalciumiontransportregulationofTcellactivationsignaltransductionTcellactivationTcelldifferentiationTcellselectiontransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcellreceptorsignalingpathway
C-reactive protein
2.0
84
80
CRPCRPP02741P02741acute-phaseresponsedefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponsenegativeregulationoflipidstoragenegativeregulationofmacrophagederivedfoamcelldifferentiationnegativeregulationofmononuclearcellproliferationopsonizationpositiveregulationofgeneexpressionpositiveregulationofsuperoxideaniongenerationregulationofinterleukin-8productionvasoconstriction
MHC class I antigen
2.0
80
82
J9UGS3J9UGS3J9UGS3J9UGS3
Toll-like receptor 8
2.0
37
87
TLR8TLR8Q9NR97Q9NR97cellularresponsetomechanicalstimulusdefenseresponsetovirusI-kappaBkinase/NF-kappaBsignalingimmunoglobulinmediatedimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofinterleukin-12productionpositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationoftypeIIinterferonproductionregulationofproteinphosphorylationresponsetovirustoll-likereceptor8signalingpathwaytoll-likereceptorsignalingpathway
Immunoglobulin gamma-1 heavy chain
2.0
nan
94
IGKCIGG1P01834P0DOX5adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasis
MHC class I antigen
2.0
81
82
A3F718A3F718A3F718A3F718
Anti-vesicular stomatitis virus N VHH
2.0
81
81
A0A192B6J6A0A192B6J6A0A192B6J6A0A192B6J6
Albumin
2.0
nan
90
ALBUALBUP02768P02768cellularresponsetostarvationmaintenanceofmitochondrionlocationnegativeregulationofapoptoticprocessnegativeregulationofprogrammedcelldeathretinahomeostasis
BTB/POZ domain-containing protein KCTD5
2.0
52
85
KCTD5KCTD5Q9NXV2Q9NXV2proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinhomooligomerization
Beta-galactosidase
2.0
60
85
BGALBGALP16278P16278cellularcarbohydratemetabolicprocessgalactosecatabolicprocessglycosphingolipidmetabolicprocessheparansulfateproteoglycancatabolicprocesskeratansulfatecatabolicprocessresponsetocortisoneresponsetoThyroglobulintriiodothyronine
If kappa light chain
2.0
87
81
A2NHM3A2NHM3A2NHM3A2NHM3
Ig-like domain-containing protein
2.0
57
88
Q31206Q31206Q31206Q31206antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbinnereardevelopment
MAb 110 light chain
2.0
nan
88
A0A0F7R1P3A0A0F7R5U8A0A0F7R1P3A0A0F7R5U8
Carboxypeptidase O
2.8
47
88
CBPOCBPOQ8IVL8Q8IVL8proteolysis
Immunoglobulin lambda constant 3
2.0
nan
91
IGLC3A8K008P0DOY3A8K008adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
HLA class I histocompatibility antigen B-57
2.1
82
82
Q9MYI6Q9MYI6Q9MYI6Q9MYI6antigenprocessingandpresentationimmuneresponse
Cytokine receptor common subunit gamma
2.0
59
86
IL2RGIL2RGP31785P31785CD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationcytokine-mediatedsignalingpathwaygeneexpressionimmuneresponseinterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayinterleukin-7-mediatedsignalingpathwaymatureBcelldifferentiationpositiveregulationofBcelldifferentiationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofphagocytosispositiveregulationofTcelldifferentiationinthymussignaltransductionTcelldifferentiationinthymus
HLA class II histocompatibility antigen, DP beta 1 chain
2.0
78
81
DPB1DPB1P04440P04440adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcellproliferationpositiveregulationoftypeIIinterferonproductionTcellreceptorsignalingpathway
Pancreatic lipase-related protein 2
2.0
59
86
LIPR2LIPR2P54317P54317galactolipidcatabolicprocesslipidcatabolicprocesslipiddigestionphosphatidylcholinecatabolicprocessphospholipidcatabolicprocesstriglyceridecatabolicprocesstriglyceridemetabolicprocess
Seipin
2.0
43
84
BSCL2BSCL2Q96G97Q96G97fatcelldifferentiationlipidcatabolicprocesslipiddropletformationlipiddropletorganizationlipidstoragenegativeregulationoflipidcatabolicprocesspositiveregulationofcold-inducedthermogenesis
Interleukin-7 receptor subunit alpha
2.0
62
85
IL7RAIL7RAP16871P16871BcellhomeostasisBcellproliferationcellmorphogenesiscellsurfacereceptorsignalingpathwaycytokine-mediatedsignalingpathwaydefenseresponsetoGram-positivebacteriumgeneexpressionhemopoiesisimmuneresponselymphnodedevelopmentnegativeregulationofTcellapoptoticprocessnegativeregulationofTcellmediatedcytotoxicitypositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofTcelldifferentiationinthymusregulationofcellsizeregulationofDNArecombinationsignaltransductionTcelldifferentiationinthymusTcellhomeostasisTcellmediatedcytotoxicity
Beta-1,4-galactosyltransferase 1
2.0
42
88
B4GT1B4GT1P15291P15291acuteinflammatoryresponseangiogenesisinvolvedinwoundhealingbindingofspermtozonapellucidacelladhesiondevelopmentofsecondarysexualcharacteristicsepithelialcelldevelopmentepithelialcellproliferationextracellularmatrixorganizationgalactosemetabolicprocessglycosylationlactosebiosyntheticprocesslipidmetabolicprocessmacrophagemigrationnegativeregulationofepithelialcellproliferationoligosaccharidebiosyntheticprocesspenetrationofzonapellucidapositiveregulationofapoptoticprocesspositiveregulationofepithelialcellproliferationinvolvedinwoundhealingproteinN-linkedglycosylationregulationofacrosomereaction
N-sulphoglucosamine sulphohydrolase
2.0
59
83
SPHMSPHMP51688P51688glycosaminoglycancatabolicprocessheparansulfateproteoglycancatabolicprocess
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
2.0
63
80
MGAT1MGAT1P27115P27115inuteroembryonicdevelopmentmannosemetabolicprocessproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineUDP-N-acetylglucosaminecatabolicprocess
Repulsive guidance molecule A
2.0
45
88
RGMARGMAQ96B86Q96B86BMPsignalingpathwaymembraneproteinectodomainproteolysisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofreceptorbindingneuraltubeclosureneuronprojectiondevelopmentpositiveregulationofGTPaseactivitypositiveregulationofmembraneproteinectodomainproteolysispositiveregulationoftranscriptionbyRNApolymeraseIIregulationofBMPsignalingpathway
CD209 antigen
2.0
nan
91
CD209CD209Q9NNX6Q9NNX6adaptiveimmuneresponseantigenprocessingandpresentationBcelladhesioncell-cellrecognitionendocytosisheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinnateimmuneresponseintracellularsignaltransductionintracellulartransportofvirusleukocytecell-celladhesionpeptideantigentransportpositiveregulationofTcellproliferationpositiveregulationofvirallifecycleregulationofTcellproliferationviralentryintohostcellviralgenomereplicationvirionattachmenttohostcell
Interleukin-4
2.0
34
88
IL4IL4P05112P05112activationofJanuskinaseactivityBcellcostimulationBcelldifferentiationcholesterolmetabolicprocessdendriticcelldifferentiationextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseinnateimmuneresponseinmucosamacrophageactivationmicroglialcellactivationmyeloiddendriticcelldifferentiationnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofchronicinflammatoryresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialcellmigrationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofmacrophageactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationofosteoclastdifferentiationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactorproductionneuroinflammatoryresponsepositiveregulationofamyloid-betaclearancepositiveregulationofATPbiosyntheticprocesspositiveregulationofBcellproliferationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellularrespirationpositiveregulationofcold-inducedthermogenesispositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-templatedtranscriptionpositiveregulationofeosinophilchemotaxispositiveregulationofgeneexpressionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmacroautophagypositiveregulationofmastcelldegranulationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmononuclearcellmigrationpositiveregulationofmyoblastfusionpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcelldifferentiationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofimmuneresponseregulationofisotypeswitchingregulationofphosphorylationTcellactivationT-helper2celldifferentiationtype2immuneresponse
Interleukin-9
2.0
63
86
IL9IL9P15248P15248BcelldifferentiationBcellproliferationimmunoglobulinmediatedimmuneresponseinflammatoryresponsenegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaypositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofinterleukin-5productionregulationofpeptidyl-tyrosinephosphorylationregulationofreceptorsignalingpathwayviaJAK-STAT
Protein AF-9
2.0
60
84
AF9AF9P42568P42568anterior/posteriorpatternspecificationchromatinremodelinggeneexpressionhematopoieticstemcelldifferentiationhistoneacetylationnegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofWntsignalingpathwayplanarcellpolaritypathwayregulationofchromatinorganizationregulationofstemcelldivisionregulationoftranscriptionbyRNApolymeraseIIsegmentspecification
Hereditary hemochromatosis protein
2.0
73
83
HFEHFEQ30201Q30201BMPsignalingpathwaycellularironionhomeostasiscellularresponsetoironionhormonebiosyntheticprocessiontransportironionhomeostasismulticellularorganismalironionhomeostasisnegativeregulationofantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassInegativeregulationofCD8-positivealpha-betaTcellactivationnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofreceptorbindingnegativeregulationofsignalingreceptoractivitynegativeregulationofTcellcytokineproductionnegativeregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofferrousironbindingpositiveregulationofgeneexpressionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidehormonesecretionpositiveregulationofproteinbindingpositiveregulationofreceptorbindingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofsignalingreceptoractivitypositiveregulationoftransferrinreceptorbindingprotein-containingcomplexassemblyregulationofironiontransportregulationofproteinlocalizationtocellsurfaceresponsetoironionresponsetoironionstarvation
C-type lectin domain family 1 member B
2.0
50
86
CLC1BCLC1BQ9P126Q9P126cellsurfacereceptorsignalingpathwaydefenseresponseplateletformationsignaltransduction
SLAM family member 6
2.0
60
87
SLAF6SLAF6Q96DU3Q96DU3innateimmuneresponsepositiveregulationofinterleukin-17productionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationoftypeIIinterferonproductionTcellactivationT-helper17celllineagecommitment
C-type lectin domain family 6 member A
2.0
51
84
CLC6ACLC6AQ6EIG7Q6EIG7adaptiveimmuneresponseantifungalinnateimmuneresponsedefenseresponsetofungusdetectionofyeastimmuneresponseinnateimmuneresponsepositiveregulationofcytokineproductionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofintracellularsignaltransductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofT-helper17typeimmuneresponseresponsetoyeaststimulatoryC-typelectinreceptorsignalingpathway
Integrin alpha-L
2.0
67
86
ITALITALP20701P20701celladhesioncelladhesionmediatedbyintegrincell-celladhesioncell-matrixadhesionheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesinflammatoryresponseintegrin-mediatedsignalingpathwayleukocytecell-celladhesionmemoryTcellextravasationphagocytosisreceptorclusteringsignaltransductionTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcell
C-X-C motif chemokine 10
2.0
41
89
CXL10CXL10P02778P02778adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantiviralinnateimmuneresponsebloodcirculationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetoheatcellularresponsetointerleukin-17cellularresponsetolipopolysaccharidecellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisendothelialcellactivationGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismmuscleorgandevelopmentnegativeregulationofangiogenesisnegativeregulationofmyoblastdifferentiationnegativeregulationofmyoblastfusionneutrophilchemotaxispositiveregulationofcellpopulationproliferationpositiveregulationofmonocytechemotaxispositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofTcellmigrationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofapoptoticprocessregulationofcellpopulationproliferationregulationofendothelialtubemorphogenesisregulationofTcellchemotaxisresponsetoauditorystimulusresponsetocoldresponsetogammaradiationresponsetovitaminDsignaltransductionTcellchemotaxis
MHC class I antigen
2.0
81
83
F4NBQ1F4NBQ1F4NBQ1F4NBQ1
Interleukin-15
2.0
48
88
IL15IL15P40933P40933agingcellmaturationcell-cellsignalingcellularresponsetovitaminDextrathymicTcellselectionhyaluronanmetabolicprocessimmuneresponseinflammatoryresponseinterleukin-15-mediatedsignalingpathwaylymphnodedevelopmentmacrophagedifferentiationnaturalkillercelldifferentiationnaturalkillercellproliferationnegativeregulationofcold-inducedthermogenesisnegativeregulationofsmoothmusclecellproliferationneutrophilactivationNKTcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofimmuneresponsepositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofnaturalkillercelldifferentiationpositiveregulationofnaturalkillercellproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphagocytosispositiveregulationofproteinO-linkedglycosylationpositiveregulationofTcellproliferationpositiveregulationoftissueremodelingpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofdefenseresponsetovirusbyhostregulationofTcelldifferentiationsignaltransductionskeletalmuscleatrophytyrosinephosphorylationofSTATprotein
Src-like-adapter 2
2.0
54
84
SLAP2SLAP2Q9H6Q3Q9H6Q3antigenreceptor-mediatedsignalingpathwayBcellmediatedimmunitynegativeregulationofcalcium-mediatedsignalingnegativeregulationofTcellreceptorsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIphosphatidylinositolphosphatebiosyntheticprocessregulationofimmuneresponseTcellactivation
Neutral alpha-glucosidase AB
2.0
70
86
GANABGANABQ14697Q14697carbohydratemetabolicprocessN-glycanprocessing
TRA@ protein
2.0
76
80
Q6IRV4Q6IRV4Q6IRV4Q6IRV4
BAG family molecular chaperone regulator 5
2.0
70
86
BAG5BAG5Q9UL15Q9UL15Golgiorganizationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinrefoldingnegativeregulationofproteinubiquitinationnegativeregulationofubiquitin-proteintransferaseactivityneurondeathproteinfoldingproteinstabilizationregulationofinclusionbodyassemblyregulationofubiquitin-proteintransferaseactivity
Peptidyl-prolyl cis-trans isomerase FKBP14
2.0
47
85
FKB14FKB14Q9NWM8Q9NWM8
HLA class II histocompatibility antigen DP alpha chain
2.0
79
79
Q95HB9Q95HB9Q95HB9Q95HB9adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Pro-cathepsin H
2.0
62
85
CATHCATHO46427O46427bradykinincatabolicprocesscellularresponsetothyroidhormonestimulusdichotomoussubdivisionofterminalunitsinvolvedinlungbranchingERK1andERK2cascadeimmuneresponse-regulatingsignalingpathwaymembraneproteinproteolysismetanephrosdevelopmentnegativeregulationofapoptoticprocessneuropeptidecatabolicprocesspositiveregulationofangiogenesispositiveregulationofapoptoticsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofpeptidaseactivityproteindestabilizationproteolysisproteolysisinvolvedinproteincatabolicprocessresponsetoretinoicacidsurfactanthomeostasisTcellmediatedcytotoxicityzymogenactivation
Bone morphogenetic protein 6
2.0
72
85
BMP6BMP6P22004P22004BMPsignalingpathwaybonedevelopmentcartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoironioncellularresponsetomechanicalstimulusendochondralossificationeyedevelopmentimmuneresponseinflammatoryresponsekidneydevelopmentmalegenitaliadevelopmentmulticellularorganismalironionhomeostasisnegativeregulationofadherensjunctionorganizationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationosteoblastdifferentiationpositiveregulationofaldosteronebiosyntheticprocesspositiveregulationofaldosteronesecretionpositiveregulationofbonemineralizationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinsecretionpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularpermeabilityresponsetoactivityresponsetoglucocorticoidresponsetomagnesiumionresponsetoretinoicacidskeletalsystemdevelopmentSMADproteinsignaltransductiontypeBpancreaticcelldevelopment
IGL@ protein
2.0
94
79
Q3T101Q3T101Q3T101Q3T101
C-C motif chemokine 17
2.0
80
80
CCL17CCL17Q92583Q92583antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Fms-related tyrosine kinase 3 ligand
2.0
49
88
FLT3LFLT3LP49771P49771embryonichemopoiesispositiveregulationofcellpopulationproliferationsignaltransduction
Neutral and basic amino acid transport protein rBAT
2.0
53
86
SLC31SLC31Q07837Q07837aminoacidtransportaspartatetransmembranetransportbasicaminoacidtransportcarbohydratemetabolicprocessgeneexpressionL-cystinetransportL-glutamatetransmembranetransport
MHC class I antigen
2.0
83
83
U6BR87U6BR87U6BR87U6BR87
Interleukin-5
2.0
70
84
IL5IL5P05113P05113cytokine-mediatedsignalingpathwayimmuneresponseinflammatoryresponsepeptidyl-tyrosinephosphorylationpositiveregulationofBcellproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofeosinophildifferentiationpositiveregulationofimmunoglobulinproductionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofpodosomeassemblypositiveregulationofreceptorsignalingpathwayviaJAK-STAT
Neutrophil elastase
2.0
66
86
ELNEELNEP08246P08246acuteinflammatoryresponsetoantigenicstimulusbiosyntheticprocessofantibacterialpeptidesactiveagainstGram-negativebacteriacellularcalciumionhomeostasisdefenseresponsetobacteriumextracellularmatrixdisassemblyleukocytemigrationinvolvedininflammatoryresponsenegativeregulationofchemokineproductionnegativeregulationofchemotaxisnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-8productionnegativeregulationoftranscriptionbyRNApolymeraseIIneutrophil-mediatedkillingoffungusneutrophil-mediatedkillingofgram-negativebacteriumphagocytosispositiveregulationofimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationofleukocytetetheringorrollingpositiveregulationofMAPkinaseactivitypositiveregulationofsmoothmusclecellproliferationproteincatabolicprocessproteolysispyroptosisresponsetolipopolysaccharideresponsetoUVresponsetoyeast
IGL@ protein
2.0
nan
94
S6C4S0Q6IPQ0S6C4S0Q6IPQ0
Haptoglobin
2.0
nan
94
HPTHPTQ8SPS7Q8SPS7acuteinflammatoryresponseacute-phaseresponsedefenseresponsetobacteriumimmunesystemprocesspositiveregulationofcelldeathzymogenactivation
Heparanase
2.1
57
82
HPSEHPSEQ9Y251Q9Y251angiogenesisinvolvedinwoundhealingcell-matrixadhesionestablishmentofendothelialbarrierFactorXIIactivationheparansulfateproteoglycancatabolicprocessheparinmetabolicprocessinflammatoryresponsepositiveregulationofangiogenesispositiveregulationofautophagypositiveregulationofbloodcoagulationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofextracellularmatrixdisassemblypositiveregulationofhairfollicledevelopmentpositiveregulationofosteoblastproliferationpositiveregulationofproteinkinaseBsignalingpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofvascularendothelialgrowthfactorproductionproteintransmembranetransportproteoglycanmetabolicprocessregulationofhairfollicledevelopmentresponsetoorganicsubstancevascularwoundhealing
IGK@ protein
2.0
90
79
Q6P5S8Q6P5S8Q6P5S8Q6P5S8
Nuclear pore complex protein Nup93
2.0
77
79
NUP93NUP93Q8N1F7Q8N1F7nuclearenvelopeorganizationnuclearporecomplexassemblynucleocytoplasmictransportpoly(A)+mRNAexportfromnucleuspositiveregulationofSMADproteinsignaltransductionproteinimportintonucleusSMADproteinsignaltransduction
Lysine-specific demethylase 4B
3.8
45
86
KDM4BKDM4BO94953O94953braindevelopmentchromatinremodelinghistonelysinedemethylation
Erythropoietin receptor
2.0
85
79
EPOREPORP19235P19235braindevelopmentcytokine-mediatedsignalingpathwaydecidualizationheartdevelopmenthemopoiesispositiveregulationofcellpopulationproliferationsignaltransduction
E3 ubiquitin-protein ligase RNF31
3.2
65
94
RNF31RNF31Q96EP0Q96EP0CD40signalingpathwaydefenseresponsetobacteriumnegativeregulationofnecroptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteintargetingtomitochondrionpositiveregulationofxenophagyproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Collectin-12
2.0
52
86
COL12COL12Q8K4Q8Q8K4Q8cellularresponsetoexogenousdsRNAdefenseresponsetobacteriumimmuneresponsephagocytosisrecognitionplasmamembraneraftorganizationtoll-likereceptor3signalingpathway
Pseudokinase FAM20A
2.0
67
85
FA20AFA20AQ96MK3Q96MK3biomineraltissuedevelopmentcalciumionhomeostasisenamelmineralizationpositiveregulationofproteinphosphorylationresponsetobacteriumtootheruption
Receptor-type tyrosine-protein kinase FLT3
2.0
55
90
FLT3FLT3P36888P36888animalorganregenerationBcelldifferentiationcellularresponsetocytokinestimuluscellularresponsetoglucocorticoidstimuluscommonmyeloidprogenitorcellproliferationcytokine-mediatedsignalingpathwaydendriticcelldifferentiationhemopoiesisleukocytehomeostasislymphocyteproliferationmyeloidprogenitorcelldifferentiationpeptidyl-tyrosinephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationoftyrosinephosphorylationofSTATproteinpro-Bcelldifferentiationproteinautophosphorylationregulationofapoptoticprocessresponsetoorganonitrogencompoundtransmembranereceptorproteintyrosinekinasesignalingpathway
Leukemia inhibitory factor receptor
2.1
57
86
LIFRLIFRP42702P42702cellsurfacereceptorsignalingpathwayciliaryneurotrophicfactor-mediatedsignalingpathwaycytokine-mediatedsignalingpathwayleukemiainhibitoryfactorsignalingpathwayoncostatin-M-mediatedsignalingpathwaypositiveregulationofcellpopulationproliferationresponsetocytokine
MHC class II HLA-DQ-beta-1
2.0
88
80
O19712O19712O19712O19712adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Myeloid cell surface antigen CD33
2.0
68
86
CD33CD33P20138P20138celladhesioncell-celladhesioncell-cellsignalingimmuneresponse-inhibitingsignaltransductionnegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-8productionnegativeregulationofmonocyteactivationnegativeregulationoftumornecrosisfactorproductionpositiveregulationofproteinsecretionpositiveregulationofproteintyrosinephosphataseactivitysignaltransduction
HIV-1 gp120 core
2.0
46
87
A0A0M3KKW8A0A0M3KKW8A0A0M3KKW8A0A0M3KKW8
L-selectin
2.0
nan
91
LYAM1LYAM1P14151P14151calcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescelladhesionleukocytecell-celladhesionleukocytetetheringorrolling
HLA class II histocompatibility antigen DR beta chain
2.0
81
79
A0A0A1I7H6A0A0A1I7H6A0A0A1I7H6A0A0A1I7H6adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
CD180 antigen
2.0
53
84
CD180CD180Q99467Q99467Bcellproliferationinvolvedinimmuneresponsecellularresponsetolipopolysaccharideinflammatoryresponseinnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaypositiveregulationoflipopolysaccharide-mediatedsignalingpathway
MHC class I antigen
2.1
79
83
B1PJU7B1PJU7B1PJU7B1PJU7antigenprocessingandpresentationimmuneresponse
Low affinity immunoglobulin gamma Fc region receptor II-b
2.0
74
84
FCG2BFCG2BP31994P31994antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIcellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betacellularresponsetomoleculeofbacterialorigincerebellumdevelopmentdefenseresponseFc-gammareceptorsignalingpathwayinvolvedinphagocytosisfollicularBcelldifferentiationfolliculardendriticcellactivationimmunecomplexclearancebymonocytesandmacrophagesimmuneresponseimmunoglobulinmediatedimmuneresponseinflammatoryresponsematureBcelldifferentiationinvolvedinimmuneresponsenegativeregulationofacuteinflammatoryresponsetoantigenicstimulusnegativeregulationofantibody-dependentcellularcytotoxicitynegativeregulationofBcellactivationnegativeregulationofBcellproliferationnegativeregulationofBcellreceptorsignalingpathwaynegativeregulationofcytokineproductionnegativeregulationofcytotoxicTcelldegranulationnegativeregulationofdendriticcellantigenprocessingandpresentationnegativeregulationofdendriticcelldifferentiationnegativeregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinnegativeregulationofimmuneresponsenegativeregulationofimmunoglobulinproductionnegativeregulationofinterleukin-10productionnegativeregulationofmacrophageactivationnegativeregulationofneutrophilactivationnegativeregulationofphagocytosisnegativeregulationoftypeIhypersensitivityphagocytosisengulfmentpositiveregulationofhumoralimmuneresponsepositiveregulationofJNKcascadepositiveregulationofneurondeathpositiveregulationofphagocytosispositiveregulationofresponsetoendoplasmicreticulumstressreceptor-mediatedendocytosisregulationofadaptiveimmuneresponseregulationofBcellantigenprocessingandpresentationregulationofdendriticspinemaintenanceregulationofimmunecomplexclearancebymonocytesandmacrophagesregulationofimmuneresponseregulationofinnateimmuneresponseregulationofsignalingreceptoractivityresponsetobacteriumsignaltransduction
Growth arrest-specific protein 6
2.0
43
86
GAS6GAS6Q14393Q14393activationofproteinkinaseBactivityanimalorganregenerationapoptoticcellclearanceBcellchemotaxisbloodcoagulationcalciumiontransmembranetransportcell-substrateadhesioncellularresponsetoglucosestimuluscellularresponsetogrowthfactorstimuluscellularresponsetointerferon-alphacellularresponsetostarvationcellularresponsetovitaminKcellularresponsetoxenobioticstimulusdendriticcelldifferentiationenzyme-linkedreceptorproteinsignalingpathwayextracellularmatrixassemblyfibroblastapoptoticprocessfusionofvirusmembranewithhostplasmamembranehematopoieticstemcellmigrationtobonemarrowmyeloidcellapoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofendothelialcellapoptoticprocessnegativeregulationoffibroblastapoptoticprocessnegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-6productionnegativeregulationofmyeloidcellapoptoticprocessnegativeregulationofoligodendrocyteapoptoticprocessnegativeregulationofrenalalbuminabsorptionnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynegativeregulationoftypeIIinterferonproductionneuronmigrationpeptidyl-serinephosphorylationphagocytosispositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofdendriticcellchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglomerularfiltrationpositiveregulationofnaturalkillercelldifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphagocytosispositiveregulationofproteinexportfromnucleuspositiveregulationofproteinkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofTORsignalingproteinkinaseBsignalingproteinlocalizationtoplasmamembraneproteinphosphorylationreceptor-mediatedvirionattachmenttohostcellsignaltransductionviralentryintohostcellviralgenomereplication
Meprin A subunit beta
2.0
48
86
MEP1BMEP1BQ16820Q16820inflammatoryresponseproteolysistoxintransport
HLA class I histocompatibility antigen, alpha chain E
2.0
79
82
✔
HLAEHLAEE2G051E2G051adaptiveimmuneresponseantibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofpeptideantigenviaMHCclassICD8-positivealpha-betaTcellactivationdefenseresponsetoGram-positivebacteriuminnateimmuneresponsenaturalkillercelltoleranceinductionnegativeregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofantibody-dependentcellularcytotoxicitypositiveregulationofCD8-positivealpha-betaTcellactivationpositiveregulationofCD8-positivealpha-betaTcellproliferationpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-4productionpositiveregulationofnaturalkillercellcytokineproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedimmunitypositiveregulationofnaturalkillercellproliferationpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTRAILproductionpositiveregulationoftumornecrosisfactorproductionprotectionfromnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellmediatedimmunity
Cannabinoid receptor 2
2.0
52
86
CNR2CNR2P34972P34972adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycannabinoidsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerimmuneresponseinflammatoryresponseleukocytechemotaxisnegativeregulationofactionpotentialnegativeregulationofinflammatoryresponsenegativeregulationofmastcellactivationnegativeregulationofnitric-oxidesynthaseactivitynegativeregulationofsynaptictransmissionGABAergicregulationofmetabolicprocessresponsetoamphetamineresponsetolipopolysaccharidesensoryperceptionofpain
Agrin
2.0
59
84
AGRINAGRINP25304P25304animalorganmorphogenesiscelldifferentiationchemicalsynaptictransmissionmotorneuronapoptoticprocessnegativeregulationofP-typesodiumnegativeregulationofsodiumionexportacrossplasmamembraneneuromuscularjunctiondevelopmentneurotransmitterreceptormetabolicprocessplasmamembraneorganizationpositiveregulationoffilopodiumassemblypositiveregulationofGTPaseactivitypositiveregulationofmotorneuronapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinbindingpositiveregulationofproteingeranylgeranylationpositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofsynapticassemblyatneuromuscularjunctionpositiveregulationoftranscriptionbyRNApolymeraseIIreceptorclusteringregulationofaxonguidanceregulationofcardiacmusclecellmembranepotentialregulationofcardiacmusclecontractionregulationofGTPaseactivityregulationofmicrotubulecytoskeletonorganizationregulationofproteinphosphorylationregulationofsynapseorganizationskeletalmuscleacetylcholine-gatedchannelclusteringsynapseassemblytissuedevelopment
Platelet basic protein
2.0
47
90
CXCL7CXCL7P02775P02775antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaydefenseresponsetobacteriumglucosetransmembranetransportinflammatoryresponsekillingofcellsofanotherorganismneutrophilchemotaxispositiveregulationofcelldivision
Epithelial cell adhesion molecule
2.0
65
87
EPCAMEPCAMP16422P16422negativeregulationofcell-celladhesionmediatedbycadherinpositiveregulationofcellpopulationproliferationpositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIsignaltransductioninvolvedinregulationofgeneexpressionstemcelldifferentiationuretericbuddevelopment
MHC class I antigen
2.0
78
83
E3WHS2E3WHS2E3WHS2E3WHS2antigenprocessingandpresentationimmuneresponse
Sucrase-isomaltase, intestinal
2.1
69
85
SUISSUISP14410P14410polysaccharidedigestionsucrosecatabolicprocess
5-hydroxytryptamine receptor 2A
2.0
31
89
5HT2A5HT2AP28223P28223activationofphospholipaseCactivityagingarterysmoothmusclecontractionbehavioralresponsetococainecelldeathcellularcalciumionhomeostasischemicalsynaptictransmissiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerGprotein-coupledserotoninreceptorsignalingpathwayglycolyticprocessmemorynegativeregulationofpotassiumiontransportnegativeregulationofsynaptictransmissionglutamatergicpeptidyl-tyrosinephosphorylationphosphatidylinositol3-kinasesignalingphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayphospholipaseC-activatingserotoninreceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationoffatcelldifferentiationpositiveregulationofglycolyticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositolbiosyntheticprocesspositiveregulationofvasoconstrictionpresynapticmodulationofchemicalsynaptictransmissionproteinlocalizationtocytoskeletonregulationofdopaminesecretionreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusserotoninreceptorsignalingpathwaysleeptemperaturehomeostasisurinarybladdersmoothmusclecontraction
Type-2 angiotensin II receptor
2.0
nan
91
AGTR2AGTR2P50052P50052angiotensin-mediatedvasodilationinvolvedinregulationofsystemicarterialbloodpressurebloodvesselremodelingbraindevelopmentbrainrenin-angiotensinsystemcellsurfacereceptorsignalingpathwayexplorationbehaviorGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocGMPnucleotidesecondmessengerinflammatoryresponseintracellularsignaltransductionnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofheartratenegativeregulationofneurotrophinTRKreceptorsignalingpathwayneuronapoptoticprocessnitricoxidemediatedsignaltransductionpositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofmetanephricglomerulusdevelopmentpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphosphoproteinphosphataseactivityregulationofbloodpressureregulationofmetanephrossizeregulationofsystemicarterialbloodpressurebycirculatoryrenin-angiotensinvasodilation
MHC class I antigen
2.0
78
82
U5YJP1U5YJP1U5YJP1U5YJP1
Furin
2.0
69
82
FURINFURINP23188P23188blastocystformationdibasicproteinprocessingnegativeregulationoflow-densitylipoproteinparticlereceptorcatabolicprocessnegativeregulationoftransforminggrowthfactorbeta1productionnervegrowthfactorproductionpeptidebiosyntheticprocesspeptidehormoneprocessingpositiveregulationofcellmigrationpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationoftransforminggrowthfactorbeta1activationpositiveregulationofviralentryintohostcellproteinprocessingregulationofcholesteroltransportregulationofendopeptidaseactivityregulationofproteincatabolicprocessregulationofsignaltransductionsecretionbycellsignalpeptideprocessingvirallifecyclezymogenactivationzymogeninhibition
Protein S100-Z
2.0
73
80
S100ZS100ZQ8WXG8Q8WXG8
B-cell receptor CD22
2.0
71
82
CD22CD22P20273P20273BcellactivationcelladhesionnegativeregulationofBcellreceptorsignalingpathwaynegativeregulationofcalcium-mediatedsignalingnegativeregulationofimmunoglobulinproductionregulationofBcellproliferationregulationofendocytosisregulationofimmuneresponse
IGL@ protein
2.0
87
79
Q8N355Q8N355Q8N355Q8N355
Glycine receptor subunit beta
2.0
74
81
GLRBGLRBP48167P48167acrosomereactionadultwalkingbehaviorchemicalsynaptictransmissionchloridetransmembranetransportgamma-aminobutyricacidreceptorclusteringiontransmembranetransportiontransportnervoussystemdevelopmentnervoussystemprocessneuropeptidesignalingpathwayregulationofmembranepotentialresponsetoaminoacidrightingreflexsignaltransductionstartleresponsesynaptictransmissionglycinergicvisualperception
C-C motif chemokine 16
2.0
75
82
CCL16CCL16O15467O15467cellcommunicationcell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
C-type lectin domain family 4 member C
2.0
nan
87
CLC4CCLC4CQ8WTT0Q8WTT0adaptiveimmuneresponseantifungalinnateimmuneresponseimmuneresponse
N6-adenosine-methyltransferase non-catalytic subunit
2.0
60
83
MET14MET14Q9HCE5Q9HCE5forebrainradialglialcelldifferentiationgliogenesismRNAcatabolicprocessmRNAdestabilizationmRNAmethylationmRNAsplicingviaspliceosomenegativeregulationofhematopoieticprogenitorcelldifferentiationpositiveregulationoftranslationspermatogenesisstemcellpopulationmaintenance
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
2.0
55
86
HDBP1HDBP1Q8IV16Q8IV16cholesterolhomeostasisintracellularproteintransportpositiveregulationofchylomicronremnantclearancepositiveregulationoflipoproteinlipaseactivityproteinimportproteinlocalizationtocellsurfaceproteinstabilizationresponsetoheparintranscytosistriglyceridecatabolicprocesstriglyceridehomeostasis
HLA class II histocompatibility antigen, DP alpha 1 chain
2.0
80
79
DPA1DPA1P20036P20036adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIcellularresponsetotypeIIinterferonimmuneresponsepeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcellproliferationpositiveregulationoftypeIIinterferonproduction
Myeloid-derived growth factor
2.0
88
82
MYDGFMYDGFQ969H8Q969H8angiogenesisapoptoticprocessnegativeregulationofapoptoticprocesspositiveregulationofangiogenesispositiveregulationofendothelialcellproliferationpositiveregulationofMAPKcascadepositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseII
Killer cell immunoglobulin-like receptor 2DL1
2.0
87
81
KI2L1KI2L1P43626P43626immuneresponsenaturalkillercellinhibitorysignalingpathway
Tissue factor
2.0
45
86
TFTFP13726P13726activationofbloodcoagulationviaclottingcascadeactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofplasmaproteinsinvolvedinacuteinflammatoryresponsebloodcoagulationbloodcoagulationextrinsicpathwaybloodcoagulationfibrinclotformationbloodcoagulationintrinsicpathwaycytokine-mediatedsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-8productionpositiveregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofpositivechemotaxispositiveregulationofproteinkinaseBsignalingproteinprocessingproteolysisresponsetowounding
C-type lectin domain family 4 member M
2.0
58
85
CLC4MCLC4MQ9H2X3Q9H2X3adaptiveimmuneresponseantigenprocessingandpresentationcell-cellrecognitioninnateimmuneresponseintracellularsignaltransductionintracellulartransportofvirusleukocytecell-celladhesionpeptideantigentransportreceptor-mediatedendocytosisofvirusbyhostcellreceptor-mediatedvirionattachmenttohostcellviralentryintohostcellviralgenomereplicationvirionattachmenttohostcell
Interleukin-1 receptor-like 1
2.0
34
86
ILRL1ILRL1Q01638Q01638immuneresponseinflammatoryresponsemacrophagedifferentiationnegativeregulationofT-helper1typeimmuneresponsenegativeregulationoftypeIIinterferonproductionpositiveregulationofchemokineproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-5productionpositiveregulationofmacrophageactivationsignaltransduction
Lysosomal thioesterase PPT2
2.0
61
85
PPT2PPT2Q9UMR5Q9UMR5fatty-acyl-CoAbiosyntheticprocess
Cholinesterase
2.0
58
82
CHLECHLEP06276P06276acetylcholinecatabolicprocesscholinemetabolicprocesscocainemetabolicprocesslearningnegativeregulationofcellpopulationproliferationnegativeregulationofsynaptictransmissionneuroblastdifferentiationpeptidehormoneprocessingresponsetoalkaloidresponsetofolicacidresponsetoglucocorticoidxenobioticmetabolicprocess
Protein transport protein Sec24D
3.4
54
88
SC24DSC24DQ8IYI7Q8IYI7COPII-coatedvesiclecargoloadingendoplasmicreticulumtoGolgivesicle-mediatedtransportinuteroembryonicdevelopmentintracellularproteintransport
Carbonic anhydrase 9
2.0
66
83
CAH9CAH9Q16790Q16790morphogenesisofanepitheliumone-carbonmetabolicprocessresponsetohypoxiaresponsetotestosteroneresponsetoxenobioticstimulussecretion
P2Y purinoceptor 12
2.0
37
87
P2Y12P2Y12Q9H244Q9H244activationofphospholipaseCactivityadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycalcium-mediatedsignalingcalcium-mediatedsignalingusingextracellularcalciumsourcecellprojectionorganizationcellularresponsetoATPcytosoliccalciumsignalinginvolvedininitiationofcellmovementinglial-mediatedradialcellmigrationestablishmentoflocalizationincellGprotein-coupledreceptorsignalingpathwayhemostasisiontransportlamellipodiumassemblyphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayplateletactivationplateletaggregationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofchemotaxispositiveregulationofintegrinactivationbycellsurfacereceptorlinkedsignaltransductionpositiveregulationofiontransportpositiveregulationofmicroglialcellmigrationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofruffleassemblyregulationofchemotaxisregulationofmicroglialcellmigrationresponsetoaxoninjurysubstrate-dependentcellmigrationcellextensionvisualsystemdevelopment
Lysosome membrane protein 2
2.0
56
83
SCRB2SCRB2Q14108Q14108aminophospholipidtransportgeneexpressionpositiveregulationofneuronprojectiondevelopmentproteintargetingtolysosomereceptor-mediatedendocytosisregulationofcellularcarbohydratecatabolicprocessregulationofendosomeorganizationregulationofglucosylceramidaseactivityregulationoflysosomeorganizationsensoryperceptionofsound
Chitotriosidase-1
1.9
54
87
CHIT1CHIT1Q13231Q13231chitincatabolicprocessimmuneresponsepolysaccharidecatabolicprocesspolysaccharidedigestionresponsetobacterium
Interleukin-13
2.0
48
88
Q0PW92Q0PW92Q0PW92Q0PW92immuneresponse
C-type lectin domain family 4 member D
2.0
79
82
CLC4DCLC4DQ8WXI8Q8WXI8adaptiveimmuneresponseantifungalinnateimmuneresponsedefenseresponsetobacteriumFc-gammareceptorsignalingpathwayimmuneresponsepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmyeloiddendriticcellactivationTcelldifferentiationinvolvedinimmuneresponse
HLA class II histocompatibility antigen DQ beta chain
2.0
79
79
Q5Y7D3Q5Y7D3Q5Y7D3Q5Y7D3adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Copper chaperone for superoxide dismutase
2.0
81
85
✔
CCSCCSO14618O14618cellularresponsetooxidativestresspositiveregulationofoxidoreductaseactivityproteinmaturationbycopperiontransferremovalofsuperoxideradicalssuperoxidemetabolicprocess
Ephrin type-A receptor 3
2.0
62
86
EPHA3EPHA3P29320P29320axonguidancecelladhesioncellmigrationcellularresponsetoretinoicacidephrinreceptorsignalingpathwayfasciculationofmotorneuronaxonfasciculationofsensoryneuronaxonnegativeregulationofendocytosispeptidyl-tyrosinephosphorylationpositiveregulationofkinaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofproteinlocalizationtoplasmamembraneregulationofactincytoskeletonorganizationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblyregulationofGTPaseactivityregulationofmicrotubulecytoskeletonorganizationtransmembranereceptorproteintyrosinekinasesignalingpathway
Prostaglandin E2 receptor EP4 subtype
2.0
66
85
PE2R4PE2R4P35408P35408adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaybonedevelopmentcellularresponsetomechanicalstimuluscellularresponsetoprostaglandinEstimulusERK1andERK2cascadeimmuneresponseinflammatoryresponseJNKcascadenegativeregulationofcytokineproductionnegativeregulationofeosinophilextravasationnegativeregulationofinflammatoryresponsenegativeregulationofintegrinactivationpositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofinflammatoryresponseregulationofossificationregulationofstressfiberassemblyresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetonematodeT-helpercelldifferentiation
Fibrinogen C domain-containing protein 1
2.0
79
83
FBCD1FBCD1Q8N539Q8N539celladhesion
Alpha-2-macroglobulin
2.0
41
88
A2MGA2MGP01023P01023acuteinflammatoryresponsetoantigenicstimulusacute-phaseresponseembryonicliverdevelopmentluteinizationnegativeregulationofcomplementactivationlectinpathwaynegativeregulationofendopeptidaseactivityresponsetocarbondioxideresponsetoglucocorticoidresponsetonutrientresponsetoprostaglandinEstemcelldifferentiation
BPI fold-containing family A member 1
2.0
65
87
BPIA1BPIA1Q9NP55Q9NP55antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetovirusimmuneresponseinnasopharyngeal-associatedlymphoidtissueinnateimmuneresponsemulticellularorganismalwaterhomeostasisnegativeregulationofsingle-speciesbiofilmformationinoronhostorganismregulationofsodiumiontransmembranetransportsurfactanthomeostasis
T-cell surface glycoprotein CD1a
2.0
81
80
CD1ACD1AP06126P06126adaptiveimmuneresponseantigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbimmuneresponsepositiveregulationofTcellmediatedcytotoxicity
Interleukin-20 receptor subunit alpha
2.0
63
86
I20RAI20RAQ9UHF4Q9UHF4cytokine-mediatedsignalingpathwaypositiveregulationofintrinsicapoptoticsignalingpathwayregulationofboneresorption
Immunoglobulin kappa variable 3-20
2.0
91
79
KV320KV320P18136P18136adaptiveimmuneresponseantibacterialhumoralresponseglomerularfiltrationimmuneresponse
Alpha-1-acid glycoprotein 2
2.0
59
86
A1AG2A1AG2P19652P19652acute-phaseresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-1productionpositiveregulationoftumornecrosisfactorproductionregulationofimmunesystemprocess
IgG H chain
2.0
86
79
S6BGE0S6BGE0S6BGE0S6BGE0
MHC class II antigen
2.0
79
80
A0A6B9KAL0A0A6B9KAL0A0A6B9KAL0A0A6B9KAL0adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Protein timeless homolog
2.0
56
87
TIMTIMQ9UNS1Q9UNS1branchingmorphogenesisofanepithelialtubecellcyclephasetransitioncelldivisioncellularresponsetobleomycincellularresponsetocisplatincellularresponsetoDNAdamagestimuluscellularresponsetohydroxyureacircadianrhythmdetectionofabioticstimulusDNArepairDNAreplicationcheckpointsignalinglungdevelopmentmorphogenesisofanepitheliumnegativeregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofcircadianrhythmreplicationforkarrestreplicationforkprotection
Beta-2-microglobulin
2.0
85
79
E2RN10E2RN10E2RN10E2RN10antigenprocessingandpresentationofpeptideantigenviaMHCclassIimmuneresponse
C-X-C motif chemokine 13
2.0
57
86
CXL13CXL13O43927O43927activationofGTPaseactivityantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideBcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaychronicinflammatoryresponsedefenseresponsetobacteriumendothelialcellchemotaxistofibroblastgrowthfactorgerminalcenterformationimmuneresponseinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxisacrosshighendothelialvenulenegativeregulationofendothelialcellchemotaxistofibroblastgrowthfactorneutrophilchemotaxispositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofintegrinactivationpositiveregulationofTcellchemotaxisregulationofangiogenesisregulationofhumoralimmuneresponse
Pentraxin-related protein PTX3
2.0
65
85
PTX3PTX3P26022P26022extracellularmatrixorganizationinflammatoryresponseinnateimmuneresponsenegativeregulationbyhostofviralexo-alpha-sialidaseactivitynegativeregulationbyhostofviralglycoproteinmetabolicprocessnegativeregulationbyhostofviralprocessnegativeregulationofexo-alpha-sialidaseactivitynegativeregulationofglycoproteinmetabolicprocessnegativeregulationofviralentryintohostcellopsonizationovariancumulusexpansionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofphagocytosisresponsetoyeast
HLA class II histocompatibility antigen DP beta chain
2.0
78
80
Q5EP54Q5EP54Q5EP54Q5EP54adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
HLA-B*3507
2.0
84
81
C5MK56C5MK56C5MK56C5MK56antigenprocessingandpresentationimmuneresponse
Vesicle-associated membrane protein-associated protein B/C
2.0
79
78
VAPBVAPBO95292O95292cellularcalciumionhomeostasisCOPII-coatedvesiclebuddingendoplasmicreticulummembraneorganizationendoplasmicreticulumorganizationendoplasmicreticulumtoGolgivesicle-mediatedtransportendoplasmicreticulumunfoldedproteinresponseendoplasmicreticulum-plasmamembranetetheringIRE1-mediatedunfoldedproteinresponsemodulationbyhostofviralRNAgenomereplicationnegativeregulationbyhostofviralgenomereplicationnegativeregulationbyvirusofviralproteinlevelsinhostcellpositiveregulationbyhostofviralgenomereplicationpositiveregulationofviralgenomereplicationsuppressionofviralreleasebyhostviralreleasefromhostcell
GHRH receptor splice variant 1
2.0
62
86
Q9HB45Q9HB45Q9HB45Q9HB45cellsurfacereceptorsignalingpathway
Prostate-specific antigen
2.0
66
84
KLK3KLK3P07288P07288negativeregulationofangiogenesispositiveregulationofantibacterialpeptideproductionproteinmetabolicprocessproteolysisregulationofsystemicarterialbloodpressurezymogenactivation
IgG H chain
2.0
85
80
S6B2B6S6B2B6S6B2B6S6B2B6
H-2 class II histocompatibility antigen, A-D alpha chain
3.0
nan
85
HA2DINS1P04228P01325adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigennegativeregulationofTcellproliferationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcelldifferentiationactivationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcellularresponsetoglucosestimulusfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessglucosetransmembranetransportinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstreceptorinternalizationregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationoftransmembranetransporteractivityresponsetocAMPresponsetocytokineresponsetometforminvasodilationwoundhealing
Immunoglobulin kappa variable 4-1
2.0
87
81
KV401KV401P01625P01625adaptiveimmuneresponseimmuneresponse
Beta-secretase 1
3.0
56
84
BACE1BACE1P56817P56817amyloidfibrilformationamyloidprecursorproteincatabolicprocessamyloid-betaformationamyloid-betametabolicprocesscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetomanganeseiondetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainmembraneproteinectodomainproteolysispositiveregulationofneuronapoptoticprocessprepulseinhibitionpresynapticmodulationofchemicalsynaptictransmissionproteinprocessingproteolysisresponsetoleadionresponsetoradiationsignalingreceptorligandprecursorprocessing
IgG H chain
2.0
nan
94
S6B291IGKCS6B291P01834adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationretinahomeostasis
Neuronal acetylcholine receptor subunit alpha-7
2.0
70
82
ACHA7ACHA7P36544P36544acetylcholinereceptorsignalingpathwaycalciumiontransportcellularcalciumionhomeostasischemicalsynaptictransmissioncognitiondendritearborizationdendriticspineorganizationiontransmembranetransportiontransportlearningormemorymembranedepolarizationmemorymodulationofexcitatorypostsynapticpotentialnegativeregulationofamyloid-betaformationnegativeregulationoftumornecrosisfactorproductionnervoussystemprocesspositiveregulationofamyloid-betaformationpositiveregulationofangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofCoA-transferaseactivitypositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoflong-termsynapticpotentiationpositiveregulationofMAPKcascadepositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationregulationofamyloidfibrilformationregulationofamyloidprecursorproteincatabolicprocessregulationofmembranepotentialregulationofneurondeathregulationofnitricoxidemetabolicprocessresponsetoacetylcholineresponsetoamyloid-betaresponsetohypoxiaresponsetonicotinesensoryprocessingshort-termmemorysignaltransductionsynapseorganizationsynaptictransmissioncholinergic
Spermine oxidase
2.0
59
84
SMOXSMOXQ9NWM0Q9NWM0polyaminebiosyntheticprocesspolyaminecatabolicprocesssperminecatabolicprocessxenobioticmetabolicprocess
Lysozyme C
2.0
44
88
LYSCLYSCP61626P61626antimicrobialhumoralresponsecytolysisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponsekillingofcellsofanotherorganismmetabolicprocessretinahomeostasis
C-C motif chemokine 1
2.1
48
85
CCL1CCL1P22362P22362antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofmonocytechemotaxissignaltransductionviralprocess
Contactin-4
2.0
77
83
CNTN4CNTN4Q14BL8Q14BL8braindevelopmentcelladhesionnegativeregulationofneurondifferentiationnervoussystemdevelopmentneuronprojectiondevelopment
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
2.0
73
78
DAPP1DAPP1Q9UN19Q9UN19proteindephosphorylationsignaltransduction
Acetylcholinesterase
2.0
66
81
ACESACESP21836P21836acetylcholinecatabolicprocessacetylcholinemetabolicprocessacetylcholinereceptorsignalingpathwaycelladhesioncholinemetabolicprocessneurondeathosteoblastdevelopmentpositiveregulationofaxonogenesispositiveregulationofcold-inducedthermogenesispositiveregulationofdendritemorphogenesisreceptorinternalizationregulationofreceptorrecyclingresponsetoantibioticresponsetoinsulinretinadevelopmentincamera-typeeyesynapseassembly
IgG H chain
2.0
nan
94
S6C4S0Q6IPQ0S6C4S0Q6IPQ0
Xyloside xylosyltransferase 1
2.0
61
86
XXLT1XXLT1Q3U4G3Q3U4G3O-glycanprocessing
Adhesion G protein-coupled receptor B1
2.0
nan
91
AGRB1AGRB1Q3UHD1Q3UHD1adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayapoptoticcellclearancecellsurfacereceptorsignalingpathwaydefenseresponsetoGram-negativebacteriumengulfmentofapoptoticcellinnateimmuneresponsemuscleorgandevelopmentnegativeregulationofangiogenesisnegativeregulationofendothelialcellmigrationnegativeregulationofproteincatabolicprocessnegativeregulationofproteinubiquitinationnervoussystemdevelopmentphagocytosisengulfmentphagocytosisrecognitionpositiveregulationofmyoblastfusionpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsynapseassemblypostsynapticactincytoskeletonorganizationregulationofsynapticplasticity
Renin
2.0
59
87
RENIRENIP00797P00797amyloid-betametabolicprocessangiotensinmaturationcellmaturationcellularresponsetoxenobioticstimulusdrinkingbehaviorhormone-mediatedsignalingpathwaykidneydevelopmentmalegonaddevelopmentmesonephrosdevelopmentproteolysisregulationofbloodpressureregulationofMAPKcascaderenin-angiotensinregulationofaldosteroneproductionresponsetocAMPresponsetocGMPresponsetoimmobilizationstressresponsetolipopolysaccharide
IgG H chain
2.0
82
80
S6C4R2S6C4R2S6C4R2S6C4R2
HLA class II histocompatibility antigen DP alpha chain
2.0
80
79
I2G9G1I2G9G1I2G9G1I2G9G1adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
L-xylulose reductase
2.0
88
77
✔
DCXRDCXRQ7Z4W1Q7Z4W1D-xylosemetabolicprocessglucosemetabolicprocessglucuronatecatabolicprocesstoxylulose5-phosphateNADPmetabolicprocesspositiveregulationofreactiveoxygenspeciesmetabolicprocessxylulosemetabolicprocess
Natural cytotoxicity triggering receptor 2
2.1
55
85
NCTR2NCTR2O95944O95944cellulardefenseresponsesignaltransduction
C-C motif chemokine 5
3.3
64
84
CCL5CCL5P13501P13501activationofphospholipaseDactivitycalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferoncellularresponsetoviruschemokine-mediatedsignalingpathwaychemotaxisdendriticcellchemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseleukocytecell-celladhesionlipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocessnegativeregulationofviralgenomereplicationneutrophilactivationneutrophilchemotaxispositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcalciumiontransportpositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcellularbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofhomotypiccell-celladhesionpositiveregulationofinnateimmuneresponsepositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphorylationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationpositiveregulationofTcellproliferationpositiveregulationoftranslationalinitiationpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofchronicinflammatoryresponseregulationofinsulinsecretionregulationofneurondeathregulationofTcellactivationresponsetotoxicsubstanceresponsetovirus
Ephrin-A2
2.0
67
84
EFNA2EFNA2O43921O43921axonguidanceboneremodelingcell-cellsignalingephrinreceptorsignalingpathwayolfactorybulbdevelopmentosteoclastdifferentiation
Igh protein
2.0
84
80
Q6PIP8Q6PIP8Q6PIP8Q6PIP8
C-C chemokine receptor type 2
2.0
66
85
CCR2CCR2P41597P41597bloodvesselremodelingcalcium-mediatedsignalingcellchemotaxiscellularcalciumionhomeostasiscellulardefenseresponsecellularhomeostasischemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaydendriticcellchemotaxisimmuneresponseinflammatoryresponseinflammatoryresponsetowoundingmacrophagemigrationmonocyteextravasationnegativeregulationofadenylatecyclaseactivitynegativeregulationofangiogenesisnegativeregulationofeosinophildegranulationnegativeregulationoftype2immuneresponsepositiveregulationofalpha-betaTcellproliferationpositiveregulationofastrocytechemotaxispositiveregulationofCD8-positivealpha-betaTcellextravasationpositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofhematopoieticstemcellmigrationpositiveregulationofimmunecomplexclearancebymonocytesandmacrophagespositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-2productionpositiveregulationofmonocytechemotaxispositiveregulationofmonocyteextravasationpositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationpositiveregulationofTcellchemotaxispositiveregulationofT-helper1typeimmuneresponsepositiveregulationofthymocytemigrationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionreceptorsignalingpathwayviaJAK-STATregulationofinflammatoryresponseregulationofTcellcytokineproductionregulationofTcelldifferentiationregulationofvascularendothelialgrowthfactorproductionresponsetowoundingsensoryperceptionofpainT-helper17cellchemotaxis
Prostatic acid phosphatase
2.0
49
89
PPAPPPAPP15309P15309adenosinemetabolicprocessdephosphorylationlipidmetabolicprocesslysosomeorganizationnucleotidemetabolicprocesspositiveregulationofadenosinereceptorsignalingpathwaypurinenucleobasemetabolicprocessregulationofsensoryperceptionofpainthiaminemetabolicprocess
Growth/differentiation factor 2
2.0
48
88
GDF2GDF2Q9UK05Q9UK05activinreceptorsignalingpathwayangiogenesisbloodvesselmorphogenesisBMPsignalingpathwaybranchinginvolvedinbloodvesselmorphogenesiscartilagedevelopmentcellularironionhomeostasiscellularresponsetoBMPstimulusnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcellgrowthnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAreplicationnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationossificationosteoblastdifferentiationpathway-restrictedSMADproteinphosphorylationpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofcartilagedevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcelldifferentiationpositiveregulationofendothelialcellproliferationpositiveregulationofinterleukin-8productionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIISMADproteinsignaltransductiontranscriptionbyRNApolymeraseIIvasculogenesis
Ectonucleoside triphosphate diphosphohydrolase 4
2.0
80
82
ENTP4ENTP4Q9Y227Q9Y227CTPmetabolicprocessGDPcatabolicprocessnucleobase-containingsmallmoleculecatabolicprocessnucleosidediphosphatecatabolicprocessUDPcatabolicprocess
Low affinity immunoglobulin gamma Fc region receptor II-a
2.0
81
82
FCG2AFCG2AP12318P12318cellsurfacereceptorsignalingpathwayimmunesystemprocessregulationofimmuneresponse
Myc proto-oncogene protein
2.0
31
92
MYCMYCP01106P01106branchinginvolvedinuretericbudmorphogenesiscellularironionhomeostasiscellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetoUVcellularresponsetoxenobioticstimuluschromatinremodelingchromosomeorganizationenergyreservemetabolicprocessERK1andERK2cascadefibroblastapoptoticprocessG1/StransitionofmitoticcellcycleMAPKcascadenegativeregulationofapoptoticprocessnegativeregulationofcelldivisionnegativeregulationoffibroblastproliferationnegativeregulationofmonocytedifferentiationnegativeregulationofstress-activatedMAPKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIoxygentransportpositiveregulationofcellpopulationproliferationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNAmethylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofmesenchymalcellproliferationpositiveregulationofmetanephriccapmesenchymalcellproliferationpositiveregulationofmiRNAtranscriptionpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIprotein-DNAcomplexdisassemblyregulationofcellcycleprocessregulationofgeneexpressionregulationofsomaticstemcellpopulationmaintenanceregulationoftelomeremaintenanceregulationoftranscriptionbyRNApolymeraseIIresponsetogammaradiationresponsetogrowthfactorresponsetoxenobioticstimulus
C-C motif chemokine 3
3.0
54
84
CCL3CCL3P10147P10147astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
2.0
59
83
GNPTAGNPTAQ3T906Q3T906carbohydratephosphorylationlysosomeorganizationN-glycanprocessingtolysosomesecretionoflysosomalenzymes
Ig-like domain-containing protein
2.0
nan
91
IGLC3A8K008P0DOY3A8K008adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
C-X-C chemokine receptor type 4
2.0
22
91
CXCR4CXCR4P61073P61073apoptoticprocessbraindevelopmentcalcium-mediatedsignalingcardiacmusclecontractioncellchemotaxiscellularresponsetocytokinestimuluscellularresponsetoorganonitrogencompoundcellularresponsetoxenobioticstimulusCXCL12-activatedCXCR4signalingpathwaydendriticcellchemotaxisdetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainendothelialcelldifferentiationendothelialtubemorphogenesisepithelialcelldevelopmentGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsemyelinmaintenanceneurogenesisneuronmigrationneuronrecognitionpositiveregulationofcellmigrationpositiveregulationofchemotaxispositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriteextensionpositiveregulationofmacrophagemigrationinhibitoryfactorsignalingpathwaypositiveregulationofmesenchymalstemcellmigrationpositiveregulationofoligodendrocytedifferentiationpositiveregulationofvascularwoundhealingregulationofcalciumiontransportregulationofcelladhesionregulationofchemotaxisregulationofprogrammedcelldeathregulationofviralprocessresponsetoactivityresponsetohypoxiaresponsetomorphineresponsetotacrolimusresponsetoultrasoundresponsetovirustelencephaloncellmigration
Interleukin-6
2.1
44
88
IL6IL6P05231P05231acute-phaseresponsecellularresponsetohydrogenperoxidecellularresponsetolipopolysaccharidecellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusendocrinepancreasdevelopmentgerminalcenterBcelldifferentiationglucagonsecretionglucosehomeostasishepaticimmuneresponsehepatocyteproliferationhumoralimmuneresponseinflammatoryresponseinterleukin-6-mediatedsignalingpathwayliverregenerationmaintenanceofblood-brainbarriermonocytechemotaxisnegativeregulationofapoptoticprocessnegativeregulationofboneresorptionnegativeregulationofcellpopulationproliferationnegativeregulationofchemokineproductionnegativeregulationofcollagenbiosyntheticprocessnegativeregulationoffatcelldifferentiationnegativeregulationofinterleukin-1-mediatedsignalingpathwaynegativeregulationoflipidstoragenegativeregulationofneurogenesisnegativeregulationofprimarymiRNAprocessingneuroncellularhomeostasisneuronprojectiondevelopmentneutrophilapoptoticprocessneutrophilmediatedimmunityplateletactivationpositiveregulationofacuteinflammatoryresponsepositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofBcellactivationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixdisassemblypositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-17productionpositiveregulationofinterleukin-21productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofleukocytechemotaxispositiveregulationofMAPKcascadepositiveregulationofneuroinflammatoryresponsepositiveregulationofosteoblastdifferentiationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofplateletaggregationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTcellproliferationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeBpancreaticcellapoptoticprocesspositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularendothelialgrowthfactorproductionregulationofangiogenesisregulationofastrocyteactivationregulationofglucagonsecretionregulationofinsulinsecretionregulationofmicroglialcellactivationregulationofneuroinflammatoryresponseregulationofvascularendothelialgrowthfactorproductionresponsetoactivityresponsetoglucocorticoidresponsetopeptidoglycanTfollicularhelpercelldifferentiationT-helper17celllineagecommitmentvascularendothelialgrowthfactorproduction
T-lymphocyte activation antigen CD86
2.0
71
82
CD86CD86P42081P42081activationofphospholipaseCactivityactivationofproteinkinaseCactivityadaptiveimmuneresponseBcellactivationCD40signalingpathwaycellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharideimmuneresponsenegativeregulationofTcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationoflymphotoxinAproductionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofTcellproliferationpositiveregulationofT-helper2celldifferentiationTcellcostimulation
IGL@ protein
2.0
91
80
Q6GMX4Q6GMX4Q6GMX4Q6GMX4
Ig-like domain-containing protein
2.0
nan
94
Q6N089Q8TCD0Q6N089Q8TCD0
Proteasome subunit beta type-1
3.3
84
77
PSB1PSB1O09061O09061proteasomalproteincatabolicprocess
Lactoperoxidase
1.9
44
86
PERLPERLA5JUY8A5JUY8antibacterialhumoralresponsehydrogenperoxidecatabolicprocessresponsetooxidativestress
Neuronal acetylcholine receptor subunit alpha-4
2.0
50
87
ACHA4ACHA4P43681P43681actionpotentialBcellactivationbehavioralresponsetonicotinecalciumiontransportchemicalsynaptictransmissioncognitionDNArepairinhibitorypostsynapticpotentialiontransmembranetransportiontransportmembranedepolarizationnervoussystemprocessregulationofdopaminesecretionregulationofmembranepotentialresponsetohypoxiaresponsetonicotineresponsetooxidativestresssensoryperceptionofpainsignaltransductionsynaptictransmissioncholinergic
Galectin-3-binding protein
2.0
53
85
H9FUB4H9FUB4H9FUB4H9FUB4
Corticotropin-releasing factor receptor 1
2.0
57
87
CRFR1CRFR1P34998P34998activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenalglanddevelopmentbehavioralresponsetoethanolcellsurfacereceptorsignalingpathwaycellularresponsetocorticotropin-releasinghormonestimuluscorticotropinsecretionfearresponsefemalepregnancygeneraladaptationsyndromebehavioralprocessimmuneresponsenegativeregulationofvoltage-gatedcalciumchannelactivityparturitionregulationofadenylatecyclaseactivityinvolvedinGprotein-coupledreceptorsignalingpathwayregulationofcorticosteronesecretion
DNA repair protein REV1
2.0
45
88
REV1REV1Q9UBZ9Q9UBZ9DNAreplicationerror-freetranslesionsynthesiserror-pronetranslesionsynthesisresponsetoUV
Ig-like domain-containing protein
2.0
nan
94
Q6N089Q8TCD0Q6N089Q8TCD0
Neutrophil gelatinase-associated lipocalin
2.0
40
86
NGALNGALP80188P80188apoptoticprocessdefenseresponsetobacteriuminnateimmuneresponsepositiveregulationofcold-inducedthermogenesissequesteringofironionsiderophoretransport
Carboxypeptidase A4
2.0
51
81
CBPA4CBPA4Q9UI42Q9UI42histoneacetylationproteolysis
Neuronal acetylcholine receptor subunit beta-2
2.0
71
82
ACHB2ACHB2P17787P17787acetylcholinereceptorsignalingpathwayassociativelearningBcellactivationbehavioralresponsetonicotinecalciumiontransportcentralnervoussystemprojectionneuronaxonogenesischemicalsynaptictransmissioncognitioniontransmembranetransportiontransportlateralgeniculatenucleusdevelopmentlearninglocomotorybehaviormembranedepolarizationmemorynegativeregulationofactionpotentialnervoussystemprocessopticnervemorphogenesispositiveregulationofBcellproliferationpositiveregulationofdopaminesecretionregulationofcircadiansleep/wakecycleREMsleepregulationofdendritemorphogenesisregulationofdopaminemetabolicprocessregulationofdopaminesecretionregulationofmembranepotentialregulationofsynapseassemblyregulationofsynaptictransmissiondopaminergicresponsetoacetylcholineresponsetococaineresponsetoethanolresponsetohypoxiaresponsetonicotinesensoryperceptionofpainsensoryperceptionofsoundsignaltransductionsmoothmusclecontractionsocialbehaviorsynaptictransmissioninvolvedinmicturitionsynaptictransmissioncholinergicvestibulocochlearnervedevelopmentvisuallearningvisualperception
B1 bradykinin receptor
2.0
81
82
BKRB1BKRB1P46663P46663cellmigrationGprotein-coupledreceptorsignalingpathwayinflammatoryresponsenegativeregulationofbloodpressurenegativeregulationofcellgrowthnegativeregulationofproteinphosphorylationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofleukocytemigrationpositiveregulationofreleaseofsequesteredcalciumionintocytosolproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayresponsetolipopolysaccharideresponsetomechanicalstimulussensoryperceptionofpain
Hyaluronidase-1
2.1
62
86
HYAL1HYAL1Q12794Q12794carbohydratemetabolicprocesscartilagedevelopmentcellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerleukin-1cellularresponsetopHcellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetotumornecrosisfactorcellularresponsetoUV-BchondroitinsulfatecatabolicprocessembryonicskeletaljointmorphogenesishyaluronanbiosyntheticprocesshyaluronancatabolicprocesshyaluronanmetabolicprocessinflammatoryresponsenegativeregulationofcellgrowthpositiveregulationofangiogenesispositiveregulationofcelladhesionpositiveregulationofcellgrowthpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialcellproliferationpositiveregulationofG1/Stransitionofmitoticcellcyclepositiveregulationofgrowthpositiveregulationofhyaluranoncableassemblyresponsetoantibioticresponsetoreactiveoxygenspeciesresponsetovirus
Angiopoietin-1
2.0
38
86
ANGP1ANGP1Q15389Q15389activationoftransmembranereceptorproteintyrosinekinaseactivityangiogenesiscell-substrateadhesionglomerulusvasculaturedevelopmenthemopoiesisheparinbiosyntheticprocessinuteroembryonicdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcelladhesionnegativeregulationofcytokineproductioninvolvedinimmuneresponsenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofneuronapoptoticprocessnegativeregulationofproteinimportintonucleusnegativeregulationofproteinphosphorylationnegativeregulationofvascularpermeabilityneuronapoptoticprocesspositivechemotaxispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofblood-brainbarrierpermeabilitypositiveregulationofcelladhesionpositiveregulationofendothelialcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofreceptorinternalizationproteinlocalizationtocellsurfaceregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmacrophagemigrationinhibitoryfactorsignalingpathwayregulationofproteinbindingregulationofskeletalmusclesatellitecellproliferationregulationoftumornecrosisfactorproductionsproutingangiogenesisTiesignalingpathway
C-C motif chemokine 2
2.0
73
82
CCL2CCL2P13500P13500angiogenesisanimalorganmorphogenesisastrocytecellmigrationcelladhesioncellsurfacereceptorsignalingpathwaycellularhomeostasiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytokine-mediatedsignalingpathwaycytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhelperTcellextravasationhumoralimmuneresponseinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofglialcellapoptoticprocessnegativeregulationofnaturalkillercellchemotaxisnegativeregulationofneuronapoptoticprocessnegativeregulationofvascularendothelialcellproliferationneutrophilchemotaxispositiveregulationofapoptoticcellclearancepositiveregulationofcalciumionimportpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNMDAglutamatereceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationofTcellactivationproteinkinaseBsignalingproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofcellshaperesponsetobacteriumsensoryperceptionofpainsignaltransductionviralgenomereplication
Broad substrate specificity ATP-binding cassette transporter ABCG2
2.0
50
85
ABCG2ABCG2Q9UNQ0Q9UNQ0biotintransportcellulardetoxificationexportacrossplasmamembranelipidtransportorganicaniontransportrenaluratesaltexcretionriboflavintransporttransepithelialtransporttransmembranetransporttransportacrossblood-brainbarrieruratemetabolicprocessxenobiotictransportacrossblood-brainbarrier
Transferrin receptor protein 1
2.0
63
85
TFR1TFR1P02786P02786acute-phaseresponseagingcellularironionhomeostasiscellularresponsetoleukemiainhibitoryfactorcellularresponsetoxenobioticstimulusintracellularsignaltransductionironiontransportnegativeregulationofapoptoticprocessnegativeregulationofmitochondrialfusionosteoclastdifferentiationpositiveregulationofBcellproliferationpositiveregulationofboneresorptionpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofisotypeswitchingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofTcellproliferationreceptorinternalizationresponsetocopperionresponsetohypoxiaresponsetoironionresponsetomanganeseionresponsetonutrientresponsetoretinoicacidtransferrintransporttransportacrossblood-brainbarrier
Thymic stromal lymphopoietin
2.0
52
89
TSLPTSLPQ969D9Q969D9antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumnegativeregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofchemokine(C-Cmotif)ligand1productionpositiveregulationofchemokineproductionpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofgranulocytecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-5productionpositiveregulationofinterleukin-6productionpositiveregulationofmastcellactivationpositiveregulationofreceptorsignalingpathwayviaSTATpositiveregulationoftyrosinephosphorylationofSTATprotein
Copper homeostasis protein cutC homolog
2.0
88
76
CUTCCUTCQ9NTM9Q9NTM9copperionhomeostasiscopperiontransportproteintetramerization
Phosphatidylcholine-sterol acyltransferase
2.0
52
86
LCATLCATP04180P04180cholesterolhomeostasischolesterolmetabolicprocesscholesteroltransporthigh-densitylipoproteinparticleremodelinglipidmetabolicprocesslipoproteinbiosyntheticprocessphosphatidylcholinebiosyntheticprocessphosphatidylcholinemetabolicprocessphospholipidmetabolicprocessregulationofhigh-densitylipoproteinparticleassemblyresponsetocopperionresponsetoglucocorticoidreversecholesteroltransportvery-low-densitylipoproteinparticleremodeling
C-C chemokine receptor type 6
2.0
52
87
CCR6CCR6P51684P51684calcium-mediatedsignalingcellchemotaxiscellulardefenseresponsechemotaxisdendriticcellchemotaxisDN2thymocytedifferentiationDN3thymocytedifferentiationhumoralimmuneresponseimmuneresponseisotypeswitchingtoIgAisotypesleukocytemigrationinvolvedininflammatoryresponselymphocytemigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellchemotaxispositiveregulationofflagellatedspermmotilityinvolvedincapacitationregulationofTcellmigrationsignaltransductionTcellmigrationthymocytemigration
Carbonic anhydrase 12
2.0
71
82
CAH12CAH12O43570O43570chlorideionhomeostasisestrouscycleone-carbonmetabolicprocess
Anti-H5N1 hemagglutinin monoclonal anitbody H5M9 heavy chain
2.0
81
80
U5LP42U5LP42U5LP42U5LP42
Complement component C8 gamma chain
2.1
60
84
CO8ACO8GP07357P07360complementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisimmuneresponsepositiveregulationofimmuneresponse
CD1d1 antigen
2.0
79
81
A0A0R4J090A0A0R4J090A0A0R4J090A0A0R4J090
Sialic acid-binding Ig-like lectin 7
2.0
nan
89
SIGL7SIGL7Q9Y286Q9Y286celladhesion
Interferon gamma receptor 2
2.0
nan
86
INGR2INGR2P38484P38484cellsurfacereceptorsignalingpathwaycellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirusmicroglialcellactivationpositiveregulationofNMDAglutamatereceptoractivityresponsetovirustypeIIinterferon-mediatedsignalingpathway
Ficolin-2
2.0
84
81
FCN2FCN2Q15485Q15485cellsurfacepatternrecognitionreceptorsignalingpathwaycomplementactivationlectinpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumopsonizationpositiveregulationofopsonizationproteolysisrecognitionofapoptoticcell
Low-density lipoprotein receptor-related protein 4
2.0
nan
91
LRP4LRP4Q9QYP1Q9QYP1amyloid-betaclearancebycellularcatabolicprocessanatomicalstructuredevelopmentdendritemorphogenesisdorsal/ventralpatternformationembryonicdigitmorphogenesisembryoniclimbmorphogenesisendocytosisgenerationofneuronshairfollicledevelopmentkidneydevelopmentlimbdevelopmentnegativeregulationofaxonogenesisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofossificationodontogenesisofdentin-containingtoothpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofpresynapticmembraneorganizationpositiveregulationofskeletalmuscleacetylcholine-gatedchannelclusteringpostsynapticmembraneassemblypresynapticmembraneassemblyproteinlocalizationproximal/distalpatternformationreceptorclusteringregulationofproteinphosphorylationskeletalmuscleacetylcholine-gatedchannelclusteringsynapseorganizationsynapticassemblyatneuromuscularjunctionWntsignalingpathway
Cytochrome b-c1 complex subunit 6, mitochondrial
2.0
58
83
✔
QCR6QCR6P00126P00126mitochondrialelectrontransportubiquinoltocytochromec
Prolactin
2.0
nan
94
PRLPRLP01236P01236cellsurfacereceptorsignalingpathwayfemalepregnancylactationmammaryglanddevelopmentnegativeregulationofangiogenesisnegativeregulationofendothelialcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationoflactationpositiveregulationofmiRNAtranscriptionpositiveregulationofreceptorsignalingpathwayviaJAK-STATresponsetonutrientlevels
HLA class I histocompatibility antigen, E alpha chain variant
2.0
75
82
Q59EE1Q59EE1Q59EE1Q59EE1antigenprocessingandpresentationimmuneresponse
Thymocyte nuclear protein 1
2.0
48
84
THYN1THYN1Q9P016Q9P016
Cytokine receptor-like factor 2
2.0
nan
88
CRLF2CRLF2Q9HC73Q9HC73cytokine-mediatedsignalingpathwayoncostatin-M-mediatedsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofinterleukin-5productionpositiveregulationofmastcellactivationpositiveregulationofreceptorsignalingpathwayviaSTAT
N-alpha-acetyltransferase 40
2.0
41
87
NAA40NAA40Q86UY6Q86UY6histoneH2AacetylationhistoneH4acetylationlipidmetabolicprocess
Voltage-gated hydrogen channel 1
2.0
53
85
HVCN1HVCN1Q96D96Q96D96cellredoxhomeostasiscellularresponsetopHcellularresponsetozincionpositiveregulationofsuperoxideaniongenerationprotontransmembranetransportregulationofintracellularpHregulationofiontransmembranetransportresponsetopHresponsetozincion
Carbonic anhydrase 4
2.0
58
88
CAH4CAH4P22748P22748bicarbonatetransportone-carbonmetabolicprocess
Mitochondrial import inner membrane translocase subunit Tim10
2.0
67
83
✔
TIM10TIM10P62072P62072proteininsertionintomitochondrialinnermembraneproteintargetingtomitochondrionsensoryperceptionofsound
Huntingtin-interacting protein 1
2.0
57
86
HIP1HIP1O00291O00291actinfilamentorganizationactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessapoptoticsignalingpathwaycelldifferentiationclathrincoatassemblyendocytosisneurotransmitterreceptortransportpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofproteinkinaseBsignalingpositiveregulationofreceptor-mediatedendocytosispresynapticmodulationofchemicalsynaptictransmissionproteinstabilizationregulationofapoptoticprocessregulationofendocytosisregulationofpostsynapticneurotransmitterreceptorinternalization
Sema domain-containing protein
2.0
nan
89
Q8BUT0Q8BUT0Q8BUT0Q8BUT0celldifferentiationnervoussystemdevelopment
Neuroligin-4, X-linked
2.0
68
84
NLGNXNLGNXQ8N0W4Q8N0W4adultbehaviorbrainstemdevelopmentcell-celljunctionorganizationcerebellumdevelopmentchemicalsynaptictransmissionlearningmodulationofchemicalsynaptictransmissionnegativeregulationofexcitatorypostsynapticpotentialneuroncell-celladhesionneurondifferentiationorgangrowthpostsynapticmembraneassemblypresynapseassemblypresynapticmembraneassemblysocialbehaviorsynapseorganizationsynapticvesicleendocytosisvocalizationbehavior
Anti-vesicular stomatitis virus N VHH
2.0
85
79
A0A192B6J5A0A192B6J5A0A192B6J5A0A192B6J5
MHC class I antigen
2.1
79
82
Q9MYA2Q9MYA2Q9MYA2Q9MYA2
Glutathione reductase, mitochondrial
2.0
50
88
GSHRGSHRP00390P00390cellredoxhomeostasiscellularresponsetooxidativestressglutathionemetabolicprocess
Discoidin domain-containing receptor 2
3.2
45
83
DDR2DDR2Q16832Q16832biomineraltissuedevelopmentcelladhesioncellularresponsetoangiotensincellularresponsetohypoxiacellularresponsetotransforminggrowthfactorbetastimuluschondrocyteproliferationcollagenfibrilorganizationcollagen-activatedtyrosinekinasereceptorsignalingpathwayendochondralbonegrowthnegativeregulationofapoptoticprocessnegativeregulationofhydrogenperoxide-mediatedprogrammedcelldeathnegativeregulationofkinaseactivitynegativeregulationofnecroticcelldeathossificationpeptidyl-tyrosinephosphorylationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixdisassemblypositiveregulationoffibroblastmigrationpositiveregulationoffibroblastproliferationpositiveregulationofG1/Stransitionofmitoticcellcyclepositiveregulationofhepaticstellatecellactivationpositiveregulationofhepaticstellatecellproliferationpositiveregulationofkinaseactivitypositiveregulationofneurondeathpositiveregulationofosteoblastdifferentiationpositiveregulationofproteinkinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofwoundhealingproteinautophosphorylationregulationofbonemineralizationregulationofextracellularmatrixdisassemblyregulationoftissueremodelingresponsetomusclestretchsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Palmitoyl-protein thioesterase 1
2.0
44
85
✔
PPT1PPT1P45478P45478braindevelopmentlipidcatabolicprocesslysosomallumenacidificationmembraneraftorganizationnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofneuronapoptoticprocessnervoussystemdevelopmentpinocytosispositiveregulationofpinocytosispositiveregulationofreceptor-mediatedendocytosisproteindepalmitoylationproteintransportreceptor-mediatedendocytosis
Protein disulfide-isomerase A5
2.0
70
83
PDIA5PDIA5Q14554Q14554electrontransportchainproteinfolding
Fragile X messenger ribonucleoprotein 1
2.0
49
85
FMR1FMR1Q06787Q06787cellularresponsetovirusDNArepairglutamatereceptorsignalingpathwaymodulationbyhostofviralRNAgenomereplicationmRNAprocessingmRNAtransportnegativeregulationofcytoplasmictranslationnegativeregulationoflong-termsynapticdepressionnegativeregulationofmRNAcatabolicprocessnegativeregulationofsynapticvesicleexocytosisnegativeregulationoftranslationnegativeregulationoftranslationalinitiationnegativeregulationofvoltage-gatedcalciumchannelactivitynervoussystemdevelopmentpositiveregulationofdendriticspinedevelopmentpositiveregulationoffilopodiumassemblypositiveregulationofintracellulartransportofviralmaterialpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofmRNAbindingpositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftranslationregulationofalternativemRNAsplicingviaspliceosomeregulationofdendriticspinedevelopmentregulationoffilopodiumassemblyregulationofmiRNA-mediatedgenesilencingregulationofmRNAstabilityregulationofneuronalactionpotentialregulationofneurotransmittersecretionRNAsplicingRNA-mediatedgenesilencing
Sphingosine 1-phosphate receptor 1
2.0
45
88
S1PR1S1PR1P21453P21453actincytoskeletonreorganizationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayangiogenesisbloodvesselmaturationbraindevelopmentcardiacmuscletissuegrowthinvolvedinheartmorphogenesiscelladhesioncellmigrationcellpopulationproliferationchemotaxisendothelialcelldifferentiationGprotein-coupledreceptorsignalingpathwayhearttrabeculamorphogenesislamellipodiumassemblyleukocytechemotaxisnegativeregulationofstressfiberassemblyneurondifferentiationpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofGTPaseactivitypositiveregulationofpositivechemotaxispositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbonemineralizationregulationofboneresorptionregulationofcelladhesionregulationofmetabolicprocesssphingosine-1-phosphatereceptorsignalingpathwayTcellmigrationtransmissionofnerveimpulse
Nlgn1 protein
2.0
56
85
Q4KMN5Q4KMN5Q4KMN5Q4KMN5celladhesionmembraneassemblyregulationoflocalizationregulationofmembranepotentialregulationofnervoussystemprocesssynapseassembly
Cadherin-1
2.0
50
81
CADH1CADH1P12830P12830adherensjunctionorganizationcell-celladhesioncell-celladhesionviaplasma-membraneadhesionmoleculescellularresponsetoindole-3-methanolcellularresponsetolithiumionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofaxonextensionnegativeregulationofcellmigrationnegativeregulationofcell-celladhesionneuronprojectiondevelopmentpituitaryglanddevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinimportintonucleusproteinlocalizationtoplasmamembraneregulationofgeneexpressionregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionresponsetoGram-positivebacteriumresponsetotoxicsubstanceresponsetoxenobioticstimulussynapseassembly
Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a
2.0
61
85
A0A024R969A0A024R969A0A024R969A0A024R969activationofNF-kappaB-inducingkinaseactivityapoptoticprocesscarbohydratemetabolicprocessinflammatoryresponsepositiveregulationofinterleukin-8productionpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteinkinaseBsignaling
T-cell-specific surface glycoprotein CD28
2.0
66
85
CD28CD28P10747P10747apoptoticsignalingpathwayCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwayhumoralimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativethymicTcellselectionphosphatidylinositol3-kinasesignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcytokineproductionpositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsetoantigenicstimuluspositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofmitoticnucleardivisionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofTcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationpositiveregulationofviralgenomereplicationproteinkinaseBsignalingregulationofregulatoryTcelldifferentiationregulatoryTcelldifferentiationTcellactivationTcellcostimulationTcellreceptorsignalingpathwaytranscriptionbyRNApolymeraseII
Ig heavy chain variable region
2.0
86
80
A0A6B9SE04A0A6B9SE04A0A6B9SE04A0A6B9SE04
Chymase 2
2.0
65
84
O70164O70164O70164O70164proteolysis
Cryptochrome-2
4.7
74
83
CRY2PER2Q9R194O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofDNA-templatedtranscriptionnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimuluscircadianregulationoftranslationfattyacidmetabolicprocessgluconeogenesisglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationoffatcellproliferationnegativeregulationofproteinubiquitinationnegativeregulationofterminationofDNA-templatedtranscriptionnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
C-C chemokine receptor type 7
2.0
65
85
CCR7CCR7P32248P32248activationofGTPaseactivitycalcium-mediatedsignalingcellchemotaxiscellularresponsetocytokinestimulusdendriticcellchemotaxisestablishmentofTcellpolarityGprotein-coupledreceptorsignalingpathwayhomeostasisofnumberofcellsimmuneresponseinflammatoryresponselymphocytemigrationintolymphnodematureconventionaldendriticcelldifferentiationmyeloiddendriticcellchemotaxisnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofinterleukin-12productionnegativethymicTcellselectionpositiveregulationofactinfilamentpolymerizationpositiveregulationofcelladhesionpositiveregulationofcellmotilitypositiveregulationofcell-matrixadhesionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellantigenprocessingandpresentationpositiveregulationofdendriticcellchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationoffilopodiumassemblypositiveregulationofglycoproteinbiosyntheticprocessinvolvedinimmunologicalsynapseformationpositiveregulationofhumoralimmuneresponsepositiveregulationofhypersensitivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofimmunologicalsynapseformationpositiveregulationofinterleukin-12productionpositiveregulationofJNKcascadepositiveregulationofneutrophilchemotaxispositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteinkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofpseudopodiumassemblypositiveregulationofTcellcostimulationpositiveregulationofTcellreceptorsignalingpathwayregulationofdendriticcelldendriteassemblyregulationofinterleukin-1betaproductionregulationoftypeIIinterferonproductionreleaseofsequesteredcalciumionintocytosolresponsetolipopolysaccharideresponsetonitricoxideresponsetoprostaglandinEruffleorganization
Major prion protein
2.0
79
80
PRIOPRIOP78446P78446activationofproteinkinaseactivitycalcium-mediatedsignalingusingintracellularcalciumsourcecellcyclecellularcopperionhomeostasiscellularresponsetoamyloid-betacellularresponsetocopperioncellularresponsetoxenobioticstimulusdendriticspinemaintenancelearningormemorylong-termmemorynegativeregulationofactivatedTcellproliferationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofcatalyticactivitynegativeregulationofdendriticspinemaintenancenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-2productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationofproteinphosphorylationnegativeregulationofproteinprocessingnegativeregulationofTcellreceptorsignalingpathwaynegativeregulationoftypeIIinterferonproductionneuronprojectionmaintenancepositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintargetingtomembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofcalciumionimportacrossplasmamembraneregulationofcellcycleregulationofglutamatereceptorsignalingpathwayregulationofintracellularcalciumactivatedchloridechannelactivityregulationofpeptidyl-tyrosinephosphorylationregulationofpotassiumiontransmembranetransportresponsetoamyloid-betaresponsetocadmiumionresponsetooxidativestress
Induced myeloid leukemia cell differentiation protein Mcl-1
2.0
62
78
MCL1MCL1Q07820Q07820cellfatedeterminationcellularhomeostasisextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofanoikisnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofapoptoticprocessregulationofresponsetoDNAdamagestimulusresponsetocytokine
Ly6/PLAUR domain-containing protein 6
2.0
62
86
LYPD6LYPD6Q86Y78Q86Y78positiveregulationofcanonicalWntsignalingpathway
Insulin-like growth factor-binding protein 5
2.0
59
87
IBP5IBP5P24593P24593agingcellularresponsetocAMPcellularresponsetoorganiccycliccompoundfemalepregnancyglucosehomeostasishairfolliclemorphogenesisinsulin-likegrowthfactorreceptorsignalingpathwayintracellularsignaltransductionlungalveolusdevelopmentmammaryglandinvolutionnegativeregulationofcellmigrationnegativeregulationofgrowthnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofmuscletissuedevelopmentnegativeregulationofosteoblastdifferentiationnegativeregulationofskeletalmusclehypertrophynegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationnegativeregulationoftranslationosteoblastdifferentiationpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofproteinkinaseBsignalingpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationregulationofcellgrowthregulationofinsulin-likegrowthfactorreceptorsignalingpathwayresponsetogrowthhormonesignaltransductionstriatedmusclecelldifferentiationtypeBpancreaticcellproliferation
Ephrin-B3
2.0
75
84
EFNB3EFNB3Q15768Q15768adultwalkingbehavioraxonchoicepointrecognitionaxonguidancecell-cellsignalingephrinreceptorsignalingpathwaynegativeregulationofaxonogenesisnervoussystemdevelopmentpositiveregulationofpresynapseassemblypositiveregulationofsynaptictransmissionTcellcostimulationtrans-synapticsignalingbytrans-synapticcomplexmodulatingsynaptictransmission
IgG heavy chain VDJ region
2.0
nan
88
KAC4A0A1Y1B8B1P01840A0A1Y1B8B1
Interferon lambda receptor 1
2.0
64
86
INLR1INLR1Q8IU57Q8IU57cellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirusmucosalimmuneresponsenegativeregulationofcellpopulationproliferationpositiveregulationofcellularrespirationregulationofdefenseresponsetovirusbyhostresponsetotypeIIIinterferontypeIIIinterferon-mediatedsignalingpathway
Potassium channel subfamily K member 2
2.0
41
85
KCNK2KCNK2O95069O95069cardiacventricledevelopmentcellularresponsetohypoxiacochleadevelopmentGprotein-coupledreceptorsignalingpathwaymemorynegativeregulationofcardiacmusclecellproliferationnegativeregulationofDNAbiosyntheticprocesspositiveregulationofcelldeathpositiveregulationofcellularresponsetohypoxiapotassiumiontransmembranetransportresponsetoaxoninjuryresponsetomechanicalstimulusstabilizationofmembranepotential
Spindle and kinetochore-associated protein 3
2.0
60
80
SKA3SKA3Q8IX90Q8IX90celldivisionchromosomesegregationmitoticcellcycleregulationofmicrotubulepolymerizationordepolymerization
B-cell antigen receptor complex-associated protein beta chain
2.0
nan
90
CD79BCD79BP15530P15530adaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwayresponsetobacterium
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
2.0
99
78
MA1A1MA1A1P45700P45700carbohydratemetabolicprocessmannosetrimminginvolvedinglycoproteinERADpathwayN-glycanprocessingproteinglycosylationproteintargetingtoERubiquitin-dependentERADpathway
B-cell antigen receptor complex-associated protein alpha chain
2.0
71
83
CD79ACD79AP11912P11912adaptiveimmuneresponseBcellactivationBcelldifferentiationBcellproliferationBcellreceptorsignalingpathway
Receptor-interacting serine/threonine-protein kinase 1
2.0
57
83
RIPK1RIPK1Q13546Q13546amyloidfibrilformationapoptoticprocesscelldeathcellularresponsetogrowthfactorstimuluscellularresponsetohydrogenperoxidecellularresponsetotumornecrosisfactorextrinsicapoptoticsignalingpathwayinflammatoryresponsenecroptoticprocessnecroptoticsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofnecroptoticprocesspeptidyl-serineautophosphorylationpositiveregulationofapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofhydrogenperoxide-inducedcelldeathpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-6-mediatedsignalingpathwaypositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofmacrophagedifferentiationpositiveregulationofnecroptoticprocesspositiveregulationofnecroticcelldeathpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofprogrammedcelldeathpositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayprogrammednecroticcelldeathproteinautophosphorylationproteincatabolicprocessregulationofATPresponsetotumornecrosisfactorripoptosomeassemblyripoptosomeassemblyinvolvedinnecroptoticprocessTcellapoptoticprocesstumornecrosisfactor-mediatedsignalingpathway
Sperm-egg fusion protein TMEM95
2.0
nan
90
TMM95TMM95Q3KNT9Q3KNT9fusionofspermtoeggplasmamembraneinvolvedinsinglefertilization
Signal recognition particle receptor subunit alpha
2.0
64
86
✔
SRPRASRPRAP08240P08240cotranslationalproteintargetingtomembraneproteintargetingproteintargetingtoERSRP-dependentcotranslationalproteintargetingtomembranesignalsequencerecognition
Neuropeptide Y receptor type 2
2.0
63
84
NPY2RNPY2RP49146P49146adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycardiacleftventriclemorphogenesisGprotein-coupledreceptorsignalingpathwaylocomotorybehavioroutflowtractmorphogenesis
Anti-colorectal carcinoma light chain
2.1
88
80
Q7TS98Q7TS98Q7TS98Q7TS98
Poly [ADP-ribose] polymerase 1
3.2
43
93
PARP1PARP1P09874P09874apoptoticprocessATPgenerationfrompoly-ADP-D-ribosecarbohydratebiosyntheticprocesscellularresponsetoamyloid-betacellularresponsetoDNAdamagestimuluscellularresponsetoinsulinstimuluscellularresponsetonervegrowthfactorstimuluscellularresponsetooxidativestresscellularresponsetoUVcellularresponsetozinciondecidualizationDNAADP-ribosylationDNArepairdouble-strandbreakrepairinnateimmuneresponsemacrophagedifferentiationmitochondrialDNAmetabolicprocessmitochondrialDNArepairmitochondrionorganizationnegativeregulationofATPbiosyntheticprocessnegativeregulationofinnateimmuneresponsenegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcardiacmusclehypertrophypositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofmitochondrialdepolarizationpositiveregulationofmyofibroblastdifferentiationpositiveregulationofnecroptoticprocesspositiveregulationofneurondeathpositiveregulationofproteinlocalizationtonucleuspositiveregulationofsinglestrandbreakrepairpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinauto-ADP-ribosylationproteinautoprocessingproteinmodificationprocessproteinpoly-ADP-ribosylationregulationofcatalyticactivityregulationofcircadiansleep/wakecyclenon-REMsleepregulationofDNAmethylationregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwayregulationofproteinlocalizationregulationofSMADproteincomplexassemblyreplicationforkreversalresponsetoaldosteroneresponsetogammaradiationsignaltransductioninvolvedinregulationofgeneexpressiontelomeremaintenancetranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathway
IgG H chain
2.0
83
80
S6BAN1S6BAN1S6BAN1S6BAN1
Bone morphogenetic protein 3
2.1
74
84
BMP3BMP3P12645P12645cartilagedevelopmentcell-cellsignalingosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationskeletalsystemdevelopmentSMADproteinsignaltransduction
Tyrosine-protein phosphatase non-receptor type 4
2.0
71
83
PTN4PTN4P29074P29074peptidyl-tyrosinephosphorylationproteindephosphorylation
Retinoic acid receptor RXR-alpha
3.5
47
88
RXRARXRAP19793P19793anatomicalstructuredevelopmentcelldifferentiationhormone-mediatedsignalingpathwaymRNAtranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionbyRNApolymeraseIIperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofbonemineralizationpositiveregulationofcholesteroleffluxpositiveregulationofDNA-templatedtranscriptionpositiveregulationofthyroidhormonemediatedsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransporteractivitypositiveregulationofvitaminDreceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetoretinoicacidretinoicacidreceptorsignalingpathway
Transmembrane protease serine 2
2.0
68
85
TMPS2TMPS2O15393O15393positiveregulationofviralentryintohostcellproteinautoprocessingproteolysis
Interferon alpha-1/13
2.0
66
80
IFNA1IFNA1P01562P01562adaptiveimmuneresponseBcelldifferentiationBcellproliferationcellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirushumoralimmuneresponsenaturalkillercellactivationinvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationofSTATproteinresponsetoexogenousdsRNATcellactivationinvolvedinimmuneresponsetypeIinterferon-mediatedsignalingpathway
Human nkt tcr alpha chain
2.0
79
82
K7N5M3K7N5M3K7N5M3K7N5M3
Golgi-associated PDZ and coiled-coil motif-containing protein
2.0
69
82
GOPCGOPCQ9HD26Q9HD26apicalproteinlocalizationendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgitoplasmamembranetransportnegativeregulationofanionchannelactivitynegativeregulationofproteinlocalizationtocellsurfaceproteintransport
Dipeptidase 3
2.0
55
85
DPEP3DPEP3Q9H4B8Q9H4B8proteolysis
Interleukin-17F
2.0
39
90
IL17IL17FQ16552Q96PD4adaptiveimmuneresponseapoptoticprocesscelldeathcell-cellsignalingcellularresponsetointerleukin-1defenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumfibroblastactivationgeneexpressiongranulocytemigrationimmuneresponseinflammatoryresponseinnateimmuneresponseinterleukin-17-mediatedsignalingpathwayintestinalepithelialstructuremaintenancekeratinocytedifferentiationkeratinocyteproliferationNotchsignalingpathwaypositiveregulationofantimicrobialpeptideproductionpositiveregulationofbicellulartightjunctionassemblypositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-16productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductioncartilagedevelopmentnegativeregulationofangiogenesispositiveregulationofcytokineproductionpositiveregulationoflymphotoxinAproductionregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofinterleukin-2productionregulationofinterleukin-6productionregulationofinterleukin-8productionregulationoftransforminggrowthfactorbetareceptorsignalingpathway
C-X-C chemokine receptor type 2
2.0
50
86
CXCR2CXCR2P25025P25025acuteinflammatoryresponsetoantigenicstimuluscalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycellulardefenseresponsechemotaxisdendriticcellchemotaxisimmuneresponseinflammatoryresponseinterleukin-8-mediatedsignalingpathwaymetanephrictubulemorphogenesismidbraindevelopmentnegativeregulationofneutrophilapoptoticprocessneutrophilactivationneutrophilchemotaxisphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofneutrophilchemotaxispositiveregulationofvascularpermeabilityreceptorinternalizationsignaltransduction
Interferon alpha 2b
2.0
58
85
Q86UP4Q86UP4Q86UP4Q86UP4cellularresponsetovirusdefenseresponsetovirustypeIinterferon-mediatedsignalingpathway
Apoptotic chromatin condensation inducer in the nucleus
2.0
77
76
ACINUACINUQ9UKV3Q9UKV3apoptoticchromosomecondensationerythrocytedifferentiationmRNAprocessingnegativeregulationofmRNAsplicingviaspliceosomepositiveregulationofapoptoticprocesspositiveregulationofmonocytedifferentiationRNAsplicing
Potassium channel subfamily K member 10
2.0
42
84
KCNKAKCNKAP57789P57789memorypotassiumiontransmembranetransportregulationofiontransmembranetransportsignaltransductionstabilizationofmembranepotential
CD166 antigen
2.0
71
83
CD166CD166Q13740Q13740adaptiveimmuneresponseaxonextensioninvolvedinaxonguidancecelladhesionheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesmotorneuronaxonguidanceneuronprojectionextensionretinalganglioncellaxonguidancesignaltransduction
Focal adhesion kinase 1
2.0
57
89
FAK1FAK1Q8IYN9Q8IYN9angiogenesisaxonguidancecelldifferentiationcellmigrationcellmotilitydetectionofmusclestretchephrinreceptorsignalingpathwayepidermalgrowthfactorreceptorsignalingpathwayestablishmentofcellpolarityFc-gammareceptorsignalingpathwayinvolvedinphagocytosisgrowthhormonereceptorsignalingpathwayheartmorphogenesisinnateimmuneresponseintegrin-mediatedsignalingpathwaynegativeregulationofanoikisnegativeregulationofapoptoticprocessnegativeregulationofcell-celladhesionnetrin-activatedsignalingpathwaypeptidyl-tyrosinephosphorylationplacentadevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffibroblastmigrationpositiveregulationofmacrophagechemotaxispositiveregulationofmacrophageproliferationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofwoundhealingproteinautophosphorylationproteinphosphorylationregulationofcelladhesionregulationofcelladhesionmediatedbyintegrinregulationofcellpopulationproliferationregulationofcellshaperegulationofcytoskeletonorganizationregulationofendothelialcellmigrationregulationofepithelialcellmigrationregulationoffocaladhesionassemblyregulationofGTPaseactivityregulationofosteoblastdifferentiationregulationofproteinphosphorylationregulationofsubstrateadhesion-dependentcellspreadingsignalcomplexassemblytransforminggrowthfactorbetareceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
Complement C1q subcomponent subunit A
2.0
100
76
C1QAC1QAP02745P02745agingastrocyteactivationcell-cellsignalingcomplementactivationcomplementactivationclassicalpathwaycomplement-mediatedsynapsepruninginnateimmuneresponsemicroglialcellactivationneuronremodelingpositiveregulationofneurondeathsynapseorganizationsynapsepruningvertebrateeye-specificpatterning
HLA class I histocompatibility antigen, A alpha chain
2.1
79
82
B0UXQ0B0UXQ0B0UXQ0B0UXQ0antigenprocessingandpresentationimmuneresponse
Acetylcholine receptor subunit alpha
2.0
67
85
ACHAACHAP04756P04756acetylcholinereceptorsignalingpathwaycationtransportchemicalsynaptictransmissioniontransmembranetransportmusclecellcellularhomeostasismusculoskeletalmovementnervoussystemprocessneuromuscularjunctiondevelopmentneuromuscularprocessneuromuscularsynaptictransmissionneuroncellularhomeostasisneuronalactionpotentialregulationofmembranepotentialsignaltransductionskeletalmusclecontractionskeletalmuscletissuegrowthsynaptictransmissioncholinergic
Pumilio homolog 2
2.0
58
83
PUM2PUM2Q8TB72Q8TB72adiposetissuedevelopmentchromosomeorganizationhairfollicledevelopmentmiRNAprocessingmitochondrionorganizationpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofRIG-Isignalingpathwaypost-transcriptionalregulationofgeneexpressionregulationofchromosomesegregationregulationofmiRNA-mediatedgenesilencingregulationofmRNAstabilityregulationoftranslationrespiratoryelectrontransportchainskeletalsystemdevelopmentstressgranuleassembly
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
2.0
62
82
NDUBANDUBAQ9DCS9Q9DCS9aerobicrespirationmitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesis
Tissue alpha-L-fucosidase
2.0
60
84
FUCOFUCOP04066P04066fucosemetabolicprocessglycolipidcatabolicprocessglycosaminoglycancatabolicprocessglycosidecatabolicprocess
Prolyl 4-hydroxylase subunit alpha-2
2.0
68
86
✔
P4HA2PDIA1O15460P07237peptidyl-prolinehydroxylationto4-hydroxy-L-prolinecellularresponsetohypoxiacellularresponsetointerleukin-7endoplasmicreticulumtoGolgivesicle-mediatedtransportinsulinprocessinginterleukin-12-mediatedsignalingpathwayinterleukin-23-mediatedsignalingpathwaypositiveregulationofcelladhesionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofviralentryintohostcellproteinfoldingproteinfoldinginendoplasmicreticulumregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwayresponsetoendoplasmicreticulumstress
MHC class I protein
2.0
77
83
A0A890UPS4A0A890UPS4A0A890UPS4A0A890UPS4
Adhesion G-protein coupled receptor G5
2.0
72
83
AGRG5AGRG5Q8IZF4Q8IZF4adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathway
ATP-sensitive inward rectifier potassium channel 11
2.0
61
84
KCJ11KCJ11Q14654Q14654glucosemetabolicprocessinorganiccationtransmembranetransportnegativeregulationofinsulinsecretionnervoussystemprocesspotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportregulationofinsulinsecretionregulationofiontransmembranetransportregulationofmembranepotentialresponsetoATPresponsetoxenobioticstimulus
ALK and LTK ligand 1
2.0
48
90
ALKL1ALKL1Q6UXT8Q6UXT8positiveregulationofERK1andERK2cascadepositiveregulationofERK5cascadepositiveregulationofneuronprojectiondevelopment
Ig-like domain-containing protein
2.0
nan
94
Q6N095Q6PIL8Q6N095Q6PIL8
Coiled-coil-helix-coiled-coil-helix domain containing 1
2.0
47
87
F1SU49F1SU49F1SU49F1SU49mitochondrialtranslation
Voltage-dependent calcium channel gamma-8 subunit
2.0
59
86
CCG8CCG8Q8VHW5Q8VHW5neurotransmitterreceptorinternalizationneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingregulationofAMPAreceptoractivityregulationofpostsynapticmembraneneurotransmitterreceptorlevelstransmissionofnerveimpulse
RING-box protein 2
3.6
54
89
RBX2RBX2Q9UBF6Q9UBF6post-translationalproteinmodificationproteinneddylationproteinubiquitinationresponsetoredoxstateubiquitin-dependentproteincatabolicprocess
T-complex protein 1 subunit eta
2.0
80
83
TCPHTCPHQ2NKZ1Q2NKZ1bindingofspermtozonapellucidachaperone-mediatedproteinfoldingpositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationtoxintransport
Delta-type opioid receptor
2.0
64
85
OPRDOPRDP32300P32300adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadultlocomotorybehaviorcellularresponsetogrowthfactorstimuluscellularresponsetohypoxiacellularresponsetotoxicsubstanceeatingbehaviorGprotein-coupledopioidreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofprotein-containingcomplexassemblyneuropeptidesignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationregulationofcalciumiontransportregulationofmitochondrialmembranepotentialregulationofsensoryperceptionofpain
Interferon lambda-1
2.0
56
85
IFNL1IFNL1Q8IU54Q8IU54cellularresponsetovirusdefenseresponsetovirusinnateimmuneresponsenegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofinterleukin-13productionnegativeregulationofinterleukin-5productionnegativeregulationofmemoryTcelldifferentiationnegativeregulationofTcelldifferentiationnegativeregulationoftype2immuneresponsepositiveregulationofDNA-templatedtranscriptionpositiveregulationofimmuneresponsepositiveregulationofMHCclassIbiosyntheticprocesspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinreceptorsignalingpathwayviaJAK-STATtypeIIIinterferon-mediatedsignalingpathway
Tumor necrosis factor receptor superfamily member 11A
2.0
62
89
TNR11TNR11O35305O35305adaptiveimmuneresponsecellularresponsetozincionstarvationcircadiantemperaturehomeostasislymphnodedevelopmentmammaryglandalveolusdevelopmentmultinuclearosteoclastdifferentiationossificationosteoclastdifferentiationpositiveregulationofboneresorptionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofERK1andERK2cascadeviaTNFSF11-mediatedsignalingpositiveregulationoffevergenerationbypositiveregulationofprostaglandinsecretionpositiveregulationofJUNkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivityresponsetocytokineresponsetoethanolresponsetoinsulinresponsetointerleukin-1responsetolipopolysaccharideresponsetomechanicalstimulusresponsetoorganiccycliccompoundresponsetoradiationresponsetotumornecrosisfactorTNFSF11-mediatedsignalingpathwaytumornecrosisfactor-mediatedsignalingpathway
Cathepsin E
2.0
61
87
CATECATEP14091P14091antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIproteinautoprocessingproteolysis
Cell adhesion molecule 1
2.0
86
78
CADM1CADM1Q9BY67Q9BY67apoptoticprocessbraindevelopmentcelldifferentiationcellrecognitiondetectionofstimulusheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomophiliccelladhesionviaplasmamembraneadhesionmoleculesimmunesystemprocessliverdevelopmentnegativeregulationofERBB4signalingpathwaynegativeregulationofproteinphosphorylationpositiveregulationofcytokineproductionpositiveregulationofnaturalkillercellmediatedcytotoxicityspermatogenesissusceptibilitytonaturalkillercellmediatedcytotoxicity
Neuronal acetylcholine receptor subunit alpha-3
2.0
41
88
ACHA3ACHA3P32297P32297acetylcholinereceptorsignalingpathwayactivationoftransmembranereceptorproteintyrosinekinaseactivitybehavioralresponsetonicotinechemicalsynaptictransmissionexcitatorypostsynapticpotentialiontransmembranetransportiontransportlocomotorybehaviormembranedepolarizationnervoussystemdevelopmentnervoussystemprocessregulationofacetylcholinesecretionneurotransmissionregulationofdendritemorphogenesisregulationofmembranepotentialregulationofsmoothmusclecontractionresponsetoacetylcholinesignaltransductionsynaptictransmissioninvolvedinmicturitionsynaptictransmissioncholinergic
Major prion protein
2.0
86
82
Q58YZ3Q58YZ3Q58YZ3Q58YZ3proteinhomooligomerization
Growth/differentiation factor 15
2.0
50
87
GDF15GDF15Q99988Q99988BMPsignalingpathwaycell-cellsignalingglialcell-derivedneurotrophicfactorreceptorsignalingpathwaynegativeregulationofgrowthhormonereceptorsignalingpathwaynegativeregulationofmulticellularorganismgrowthpositiveregulationofMAPKcascadepositiveregulationofmyoblastfusionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofproteinkinaseBsignalingreductionoffoodintakeinresponsetodietaryexcesssignaltransductionSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
IgG H chain
2.0
85
80
S6B2A6S6B2A6S6B2A6S6B2A6
G-protein-signaling modulator 2
2.0
66
82
GPSM2GPSM2Q8VDU0Q8VDU0celldivisionestablishmentofmitoticspindleorientationmaintenanceofcentrosomelocationmitoticspindleorganizationpositiveregulationofproteinlocalizationtocellcortexpositiveregulationofspindleassemblyRanproteinsignaltransductionregulationofmitoticspindleorganization
Ceruloplasmin
2.0
40
83
G3V7K3G3V7K3G3V7K3G3V7K3
Fibroblast growth factor receptor 4
2.0
80
81
FGFR4FGFR4P22455P22455cellmigrationcholesterolhomeostasisfibroblastgrowthfactorreceptorsignalingpathwayglucosehomeostasispeptidyl-tyrosinephosphorylationphosphateionhomeostasispositiveregulationofcatalyticactivitypositiveregulationofcellpopulationproliferationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofproteolysisproteinautophosphorylationregulationofbileacidbiosyntheticprocessregulationofextracellularmatrixdisassemblyregulationoflipidmetabolicprocesstransmembranereceptorproteintyrosinekinasesignalingpathway
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
2.0
57
86
PDE8APDE8AO60658O60658cAMPcatabolicprocesscellularresponsetoepidermalgrowthfactorstimulusnegativeregulationofcelldeathnegativeregulationofhydrogenperoxide-inducedcelldeathpositiveregulationofERK1andERK2cascadepositiveregulationofproteinphosphorylationregulationofDNA-templatedtranscriptionsignaltransduction
Profilin-2
2.0
63
86
PROF2PROF2Q9EPC6Q9EPC6actincytoskeletonorganizationmodificationofpostsynapticactincytoskeletonmodulationofchemicalsynaptictransmissionnegativeregulationofactinfilamentpolymerizationnegativeregulationofepithelialcellmigrationnegativeregulationofruffleassemblypositiveregulationofactinfilamentbundleassemblypositiveregulationofactinfilamentpolymerizationpositiveregulationofATP-dependentactivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofstressfiberassemblypresynapticmodulationofchemicalsynaptictransmissionproteinstabilizationregulationofactinfilamentpolymerizationregulationofsynapticvesicleexocytosis
Allergen Fel d 4
2.0
50
86
G1LK14G1LK14G1LK14G1LK14
Placenta growth factor
2.0
59
88
PLGFPLGFP49763P49763animalorganregenerationcelldifferentiationcell-cellsignalingcellularresponsetohormonestimulusfemalepregnancyinductionofpositivechemotaxispositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofmastcellchemotaxispositiveregulationofproteinphosphorylationresponsetohypoxiaresponsetoxenobioticstimulussignaltransductionsproutingangiogenesisvascularendothelialgrowthfactorreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathway
Lysosomal acid lipase/cholesteryl ester hydrolase
2.0
60
88
LICHLICHP38571P38571cellmorphogenesisepithelialcellproliferationhomeostasisofnumberofcellswithinatissueinflammatoryresponselipidcatabolicprocesslow-densitylipoproteinparticleclearancelungdevelopmentmacrophagehomeostasissterolmetabolicprocesstissueremodeling
Protein O-glucosyltransferase 1
2.0
64
85
✔
PGLT1PGLT1Q8NBL1Q8NBL1axialmesodermdevelopmentcirculatorysystemdevelopmentgastrulationmuscletissuedevelopmentparaxialmesodermdevelopmentpositiveregulationofNotchsignalingpathwayproteinO-linkedglycosylationproteinO-linkedglycosylationviaserineregulationofgastrulationsomitogenesis
Probable JmjC domain-containing histone demethylation protein 2C
2.0
64
83
JHD2CJHD2CQ15652Q15652bloodcoagulationchromatinorganizationhistoneH3-K9demethylationregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Poly(rC)-binding protein 1
2.0
51
87
✔
PCBP1PCBP1Q15365Q15365positiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionregulationofRNAmetabolicprocessviralRNAgenomereplication
5-hydroxytryptamine receptor 5A
2.0
64
85
5HT5A5HT5AP47898P47898adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingserotoninreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhippocampusdevelopmentresponsetoestradiol
Inactive tyrosine-protein kinase transmembrane receptor ROR1
2.0
80
83
ROR1ROR1Q01973Q01973astrocytedevelopmentinnereardevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofkinaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofphosphatidylinositol3-kinasesignalingsensoryperceptionofsoundtransmembranereceptorproteintyrosinekinasesignalingpathway
Cytochrome c oxidase copper chaperone
2.0
42
87
COX17COX17Q14061Q14061copperiontransportgenerationofprecursormetabolitesandenergymitochondrialcytochromecoxidaseassemblypositiveregulationofcellpopulationproliferationpositiveregulationofcytochrome-coxidaseactivitysequesteringofmetalion
TRA@ protein
2.0
66
82
Q6PJ56Q6PJ56Q6PJ56Q6PJ56
Lysosome-associated membrane glycoprotein 3
2.0
54
83
LAMP3LAMP3Q9UQV4Q9UQV4adaptiveimmuneresponseestablishmentofproteinlocalizationtoorganellenegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofproteasomalproteincatabolicprocesspositiveregulationofgeneexpressionregulationofautophagyregulationofvirallifecycleresponsetointerferon-alpha
Anti-(ED-B) scFV
2.0
85
81
A2KBC1A2KBC1A2KBC1A2KBC1
Interleukin-20
2.0
77
82
IL20IL20Q9NYY1Q9NYY1osteoclastdifferentiationpositiveregulationofepidermalcelldifferentiationpositiveregulationofkeratinocytedifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofinflammatoryresponse
Ubiquitin carboxyl-terminal hydrolase 7
2.0
76
79
UBP7UBP7Q93009Q93009histoneH2BconservedC-terminallysinedeubiquitinationmaintenanceofDNAmethylationmonoubiquitinatedproteindeubiquitinationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofDNAdemethylationproteindeubiquitinationproteinstabilizationproteinubiquitinationregulationofcircadianrhythmregulationofDNA-bindingtranscriptionfactoractivityregulationofgluconeogenesisregulationofproteinstabilityregulationofretrogradetransportendosometoGolgiregulationofsignaltransductionbyp53classmediatorregulationoftelomerecappingrhythmicprocesstranscription-couplednucleotide-excisionrepairubiquitin-dependentproteincatabolicprocess
Bone morphogenetic protein receptor type-1B
2.0
51
89
BMR1BBMR1BP36898P36898BMPsignalingpathwaybonedevelopmentcamera-typeeyedevelopmentcartilagecondensationcelldifferentiationcellularresponsetoBMPstimuluscellularresponsetogrowthfactorstimuluscentralnervoussystemneurondifferentiationchondrocytedevelopmentchondrocytedifferentiationdorsal/ventralpatternformationendochondralbonemorphogenesisestrogenbiosyntheticprocesseyedevelopmentinflammatoryresponsenegativeregulationofchondrocyteproliferationosteoblastdifferentiationovariancumulusexpansionovulationcyclepositiveregulationofbonemineralizationpositiveregulationofcartilagedevelopmentpositiveregulationofchondrocytedifferentiationpositiveregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofgeneexpressionpositiveregulationofosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationproteoglycanbiosyntheticprocessretinadevelopmentincamera-typeeyeretinalganglioncellaxonguidancetransforminggrowthfactorbetareceptorsignalingpathwaytransmembranereceptorproteinserine/threoninekinasesignalingpathway
Killer cell immunoglobulin-like receptor 2DS4
2.0
89
81
KI2S4KI2S4P43632P43632
Epididymis luminal protein 213
2.0
91
80
V9HW34V9HW34V9HW34V9HW34
Pancreatic lipase-related protein type 2
2.0
nan
86
Q95KP4Q95KP4Q95KP4Q95KP4lipidcatabolicprocess
IGL c1310_light_IGKV1-12_IGKJ4
2.0
82
81
A0A5C2FYK4A0A5C2FYK4A0A5C2FYK4A0A5C2FYK4
Neuronal acetylcholine receptor subunit alpha-2
2.0
76
81
ACHA2ACHA2Q15822Q15822cellularresponsetonicotinechemicalsynaptictransmissioniontransmembranetransportiontransportmembranedepolarizationmodulationofinhibitorypostsynapticpotentialnervoussystemprocessregulationofmembranepotentialresponsetoacetylcholineresponsetonicotinesignaltransductionsynaptictransmissioncholinergic
Transferrin receptor protein 1
2.0
61
86
A0A060BIS8A0A060BIS8A0A060BIS8A0A060BIS8cellularironionhomeostasisreceptorinternalizationtransferrintransport
CTP synthase 1
2.0
76
81
PYRG1PYRG1P70698P70698"denovoCTPbiosyntheticprocess"BcellproliferationCTPbiosyntheticprocessglutaminemetabolicprocesspyrimidinenucleobasebiosyntheticprocessTcellproliferation
B-lymphocyte antigen CD19
2.0
31
87
CD19CD19P15391P15391antigenreceptor-mediatedsignalingpathwayBcellproliferationinvolvedinimmuneresponseBcellreceptorsignalingpathwayB-1Bcelldifferentiationimmunoglobulinmediatedimmuneresponsepositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofreleaseofsequesteredcalciumionintocytosolregulationofBcellactivationregulationofBcellreceptorsignalingpathway
Lactotransferrin
2.1
82
82
Q5EK51Q5EK51Q5EK51Q5EK51antibacterialhumoralresponseantifungalhumoralresponseossificationproteolysisregulationofcytokineproduction
Scavenger receptor cysteine-rich type 1 protein M130
2.1
50
89
C163AC163AQ2VL90Q2VL90acute-phaseresponse
IgG H chain
2.0
86
80
S6BAM6S6BAM6S6BAM6S6BAM6
Epididymis luminal protein 214
2.1
nan
94
V9HW68Q7Z3Y4V9HW68Q7Z3Y4
Epithelial discoidin domain-containing receptor 1
2.1
70
84
DDR1DDR1Q08345Q08345axondevelopmentbranchinginvolvedinmammaryglandductmorphogenesiscelladhesioncellpopulationproliferationcollagen-activatedtyrosinekinasereceptorsignalingpathwayeardevelopmentembryoimplantationlactationmammaryglandalveolusdevelopmentnegativeregulationofcellpopulationproliferationneuronprojectionextensionpeptidyl-tyrosineautophosphorylationpositiveregulationofkinaseactivityproteinautophosphorylationregulationofcellgrowthregulationofcell-matrixadhesionregulationofextracellularmatrixdisassemblysmoothmusclecellmigrationsmoothmusclecell-matrixadhesiontransmembranereceptorproteintyrosinekinasesignalingpathwaywoundhealingspreadingofcells
HLA class II histocompatibility antigen DQ beta chain
2.0
79
81
U3PYM0U3PYM0Q5Y7F6Q5Y7F6adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
T-cell surface glycoprotein CD3 epsilon chain
2.0
80
82
CD3ECD3EP07766P07766adaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositiveregulationoftypeIIinterferonproductionpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathway
Leucine-rich repeat-containing G-protein coupled receptor 4
2.0
49
89
LGR4LGR4Q9BXB1Q9BXB1bonemineralizationboneremodelingcanonicalWntsignalingpathwayinvolvedinmetanephrickidneydevelopmentcelldifferentiationinvolvedinmetanephrosdevelopmentcircadianregulationofgeneexpressiondigestivetractdevelopmentepithelialcellproliferationinvolvedinrenaltubulemorphogenesishairfollicledevelopmentinnateimmuneresponseintestinalstemcellhomeostasismalegenitaliadevelopmentmetanephricglomerulusdevelopmentmetanephricnephrontubulemorphogenesisnegativeregulationofcold-inducedthermogenesisnegativeregulationofcytokineproductionnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftoll-likereceptorsignalingpathwayosteoblastdifferentiationpositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofDNA-templatedtranscriptionspermatogenesis
Ephrin type-A receptor 5
2.0
61
86
EPHA5EPHA5P54756P54756axonguidancecAMP-mediatedsignalingephrinreceptorsignalingpathwayhippocampusdevelopmentneurondevelopmentpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofkinaseactivityregulationofactincytoskeletonorganizationregulationofGTPaseactivityregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulustransmembranereceptorproteintyrosinekinasesignalingpathway
V-type proton ATPase subunit S1
2.0
72
80
VAS1VAS1Q15904Q15904cellularironionhomeostasiscellularresponsetoincreasedoxygenlevelsendosomallumenacidificationendosometoplasmamembraneproteintransportGolgilumenacidificationintracellularpHreductionlysosomallumenacidificationosteoclastdevelopmentprotontransmembranetransportregulationofcellularpHsynapticvesiclelumenacidificationvacuolaracidification
Diphosphoinositol polyphosphate phosphohydrolase 2
2.0
51
83
NUDT4NUDT4Q8R2U6Q8R2U6"adenosine5-(hexahydrogenpentaphosphate)catabolicprocess"diadenosinehexaphosphatecatabolicprocessdiadenosinepentaphosphatecatabolicprocessdiphosphoinositolpolyphosphatemetabolicprocess
Glucagon like peptide 1 receptor
2.0
63
88
G1SGD4G1SGD4G1SGD4G1SGD4cellsurfacereceptorsignalingpathway
Fetuin-B
2.0
35
89
FETUBFETUBQ9QXC1Q9QXC1bindingofspermtozonapellucidanegativeregulationofendopeptidaseactivitysinglefertilization
NAD-capped RNA hydrolase NUDT12
3.6
49
86
NUD12NUD12Q9BQG2Q9BQG2circadianregulationofgeneexpressionmethylguanosine-capdecappingmRNAcatabolicprocessNADbiosynthesisvianicotinamideribosidesalvagepathwayNADcatabolicprocessNAD-capdecappingNADHmetabolicprocessNADPcatabolicprocess
Interleukin-36 receptor antagonist protein
2.0
43
86
I36RAI36RAQ9QYY1Q9QYY1antifungalhumoralresponsecellularresponsetolipopolysaccharideinflammatoryresponseinflammatoryresponsetoantigenicstimulusinnateimmuneresponsenegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofinterleukin-17productionnegativeregulationofinterleukin-6productionnegativeregulationoftypeIIinterferonproduction
Killer cell lectin-like receptor subfamily F member 2
2.0
51
86
KLRF2KLRF2D3W0D1D3W0D1naturalkillercelldegranulationpositiveregulationofcytokineproduction
Endosomal/lysosomal proton channel TMEM175
2.0
74
83
TM175TM175Q9BSA9Q9BSA9lysosomallumenpHelevationneuroncellularhomeostasisphagosome-lysosomefusionpotassiumiontransmembranetransportprotontransmembranetransport
Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
2.0
50
86
CHCH7CHCH7Q9BUK0Q9BUK0mitochondrialrespiratorychaincomplexassembly
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7
2.0
79
82
JMJD7JMJD7P0C870P0C870proteinhydroxylationproteolysis
Bis(5'-adenosyl)-triphosphatase ENPP4
2.0
46
86
ENPP4ENPP4Q9Y6X5Q9Y6X5bloodcoagulationpositiveregulationofbloodcoagulationpurineribonucleosidecatabolicprocess
Immunoglobulin lambda variable 2-14
2.0
89
81
LV214LV214P01704P01704adaptiveimmuneresponseimmuneresponse
Semaphorin-3A
2.0
59
88
SEM3ASEM3AO08665O08665apoptoticprocessaxonextensionaxonextensioninvolvedinaxonguidanceaxonguidanceaxonalfasciculationaxonogenesisinvolvedininnervationbasaldendritearborizationbranchiomotorneuronaxonguidancedendritemorphogenesisdichotomoussubdivisionofterminalunitsinvolvedinsalivaryglandbranchingepithelialcellmigrationfacialnervestructuralorganizationfacioacousticgangliondevelopmentgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamusmaintenanceofsynapsestructuremotorneuronaxonguidancenegativechemotaxisnegativeregulationofaxonextensionnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofepithelialcellmigrationnegativeregulationofneuronprojectiondevelopmentnervedevelopmentnervoussystemdevelopmentneuralcrestcellmigrationneuralcrestcellmigrationinvolvedinautonomicnervoussystemdevelopmentneuralcrestcellmigrationinvolvedinsympatheticnervoussystemdevelopmentneuronmigrationolfactorybulbdevelopmentpositiveregulationofcellmigrationpositiveregulationofmalegonaddevelopmentpositiveregulationofneuronmigrationregulationofaxonextensioninvolvedinaxonguidanceregulationofheartratesemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesemaphorin-plexinsignalingpathwayinvolvedinneuronprojectionguidancesympatheticgangliondevelopmentsympatheticneuronprojectionextensionsympatheticneuronprojectionguidancesynaptictargetrecognitiontrigeminalgangliondevelopmenttrigeminalnervestructuralorganizationventraltrunkneuralcrestcellmigration
HLA-B alpha chain (B*2706)
2.1
82
82
Q7YQB0Q7YQB0Q7YQB0Q7YQB0antigenprocessingandpresentationimmuneresponse
Aminopeptidase NAALADL1
2.0
55
81
NALDLNALDLQ9UQQ1Q9UQQ1peptidecatabolicprocessproteolysis
Natural cytotoxicity triggering receptor 3 ligand 1
2.0
75
82
NR3L1NR3L1Q68D85Q68D85regulationofimmuneresponse
Sulfhydryl oxidase
2.0
57
86
Q9NY86Q9NY86Q9NY86Q9NY86
Signal-regulatory protein beta-1
2.0
80
80
SIRB1SIRB1O00241O00241cellsurfacereceptorsignalingpathwaypositiveregulationofphagocytosispositiveregulationofTcellactivationsignaltransduction
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
2.1
51
84
CSF2RCSF2RP15509P15509cytokine-mediatedsignalingpathwaygranulocyte-macrophagecolony-stimulatingfactorsignalingpathwaypositiveregulationofleukocyteproliferationproteinphosphorylationreceptorsignalingpathwayviaJAK-STAT
Coiled-coil-helix-coiled-coil-helix domain-containing protein 5
2.0
41
87
✔
CHCH5CHCH5Q9BSY4Q9BSY4cellularrespiration
Nectin-3
2.0
70
83
NECT3NECT3Q9NQS3Q9NQS3establishmentofproteinlocalizationtoplasmamembranefertilizationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomophiliccelladhesionviaplasmamembraneadhesionmoleculeslensmorphogenesisincamera-typeeyeproteinlocalizationtocelljunctionretinamorphogenesisincamera-typeeye
Cathelicidin antimicrobial peptide
2.0
48
88
CAMPCAMPP49913P49913antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetointerleukin-1cellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetopeptidoglycancellularresponsetotumornecrosisfactorchronicinflammatoryresponsecytolysiscytolysisbyhostofsymbiontcellsdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingbyhostofsymbiontcellsmodulationofprocessofanotherorganismneutrophilactivationpositiveregulationofangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofinterleukin-8productionpositiveregulationofproteinphosphorylationresponsetoyeast
Trem-like transcript 1 protein
2.0
58
86
TRML1TRML1Q86YW5Q86YW5calcium-mediatedsignalinginnateimmuneresponseplateletactivation
Thioredoxin-like protein 1
2.0
50
88
✔
TXNL1TXNL1O43396O43396
Dynactin subunit 6
2.0
56
87
DCTN6DCTN6O00399O00399mitoticspindleorganization
Amiloride-sensitive sodium channel subunit gamma
2.0
46
85
SCNNGSCNNGP51170P51170cellularresponsetoacidicpHcellularresponsetoaldosteronecellularresponsetoamiloridecellularresponsetovasopressincellularsodiumionhomeostasismulticellularorganismalwaterhomeostasisregulationofbloodpressuresensoryperceptionofsaltytastesensoryperceptionofsourtastesodiumionhomeostasissodiumionimportacrossplasmamembranesodiumiontransmembranetransportsodiumiontransport
MHC class II antigen
2.0
79
80
Q67AJ6Q67AJ6Q67AJ6Q67AJ6adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
IGL@ protein
2.0
91
80
Q6NS95Q6NS95Q6NS95Q6NS95
Cytochrome c oxidase assembly factor 7
2.1
67
84
✔
COA7COA7Q96BR5Q96BR5
PDZ and LIM domain protein 4
2.1
nan
90
PDLI4PDLI4P50479P50479actincytoskeletonorganizationactincytoskeletonreorganizationexcitatorychemicalsynaptictransmissionheartdevelopmentmusclestructuredevelopment
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2
2.0
65
83
F1RGE3F1RGE3F1RGE3F1RGE3
Amyloid beta precursor protein binding family B member 1
2.0
90
81
APBB1APBB1O00213O00213apoptoticprocessaxonogenesiscellularresponsetoDNAdamagestimuluschromatinorganizationhistoneH4acetylationnegativeregulationofcellcycleG1/SphasetransitionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinsecretionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionsignaltransductionsmoothmusclecontraction
Neuronal acetylcholine receptor subunit beta-3
2.0
61
87
ACHB3ACHB3Q05901Q05901chemicalsynaptictransmissioniontransmembranetransportmembranedepolarizationnervoussystemprocesspresynapticmodulationofchemicalsynaptictransmissionregulationofmembranepotentialresponsetonicotinesignaltransductionsynaptictransmissioncholinergic
Carbonic anhydrase 14
2.0
64
86
CAH14CAH14Q9ULX7Q9ULX7one-carbonmetabolicprocess
CEA-related cell adhesion molecule 1, isoform 1/2S
2.0
80
81
Q3LFS8Q3LFS8Q3LFS8Q3LFS8
Pancreatic secretory granule membrane major glycoprotein GP2
2.0
31
87
GP2GP2P55259P55259antigentranscytosisbyMcellsinmucosal-associatedlymphoidtissueinnateimmuneresponseneutrophilmigration
Sorting nexin-24
2.0
70
82
SNX24SNX24Q9Y343Q9Y343proteintransport
Polypeptide N-acetylgalactosaminyltransferase 12
2.0
62
85
GLT12GLT12Q8IXK2Q8IXK2O-glycanprocessingproteinO-linkedglycosylation
V-set domain-containing T-cell activation inhibitor 1
2.0
81
82
VTCN1VTCN1Q7Z7D3Q7Z7D3adaptiveimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofTcellactivationnegativeregulationofTcellproliferationpositiveregulationofinterleukin-2productionpositiveregulationofTcellproliferationregulationofcytokineproductionresponsetoprotozoanTcellreceptorsignalingpathway
Lambda-chain (AA -20 to 215)
2.0
93
80
A2NUT2A2NUT2A2NUT2A2NUT2
Lysosomal Pro-X carboxypeptidase
2.0
39
85
PCPPCPP42785P42785angiogenesisinvolvedinwoundhealingenergyhomeostasisglucosehomeostasisnegativeregulationofsystemicarterialbloodpressureplasmakallikrein-kinincascadeproteolysisregulationofbloodvesselendothelialcellmigrationregulationofreactiveoxygenspeciesmetabolicprocessregulationofthyroidhormonemediatedsignalingpathway
Interleukin-1 receptor-like 2
2.0
38
87
ILRL2ILRL2Q9HB29Q9HB29cellulardefenseresponseinflammatoryresponseinnateimmuneresponsepositiveregulationofinterleukin-6productionpositiveregulationofTcelldifferentiationregulationofinflammatoryresponsesignaltransduction
C-X-C motif chemokine
2.0
69
83
A0A2K5UVV0A0A2K5UVV0A0A2K5UVV0A0A2K5UVV0immuneresponseinflammatoryresponse
Cytotoxic and regulatory T-cell molecule
2.0
80
81
CRTAMCRTAMO95727O95727adaptiveimmuneresponsecellrecognitiondetectionofstimulusdetectionoftumorcellestablishmentofTcellpolarityheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeslymphocytemigrationintolymphoidorgansnegativeregulationofactivatedTcellproliferationpositiveregulationofcytokineproductionpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationoftypeIIinterferonproductionregulationofCD8-positivealpha-betaTcellactivationregulationofTcellactivationregulationofTcelldifferentiation
Atrial natriuretic peptide receptor 3
2.1
79
81
ANPRCANPRCP17342P17342adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayangiogenesisbloodvesselremodelingnegativeregulationofadenylatecyclaseactivitynegativeregulationofcold-inducedthermogenesisnegativeregulationofsmoothmusclecellproliferationosteoclastproliferationpancreaticjuicesecretionphosphatidylinositol-mediatedsignalingphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofurinevolumeregulationofbloodpressureregulationofosteoblastproliferationresponsetoischemiasignaltransductionskeletalsystemdevelopmentvasodilation
Asparagine synthetase [glutamine-hydrolyzing]
2.0
49
83
ASNSASNSP08243P08243asparaginebiosyntheticprocesscellularresponsetoglucosestarvationglutaminemetabolicprocessL-asparaginebiosyntheticprocessnegativeregulationofapoptoticprocesspositiveregulationofmitoticcellcycle
Bactericidal permeability-increasing protein
2.0
61
87
BPIBPIP17213P17213antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriuminnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaynegativeregulationofinterleukin-6productionnegativeregulationofinterleukin-8productionnegativeregulationofmacrophageactivationnegativeregulationoftumornecrosisfactorproduction
T-cell receptor, sp3.4 alpha chain
2.0
76
82
K7N5N2K7N5N2K7N5N2K7N5N2
Neurotensin receptor type 1
2.0
63
84
NTR1NTR1P30989P30989adultlocomotorybehaviorchemicalsynaptictransmissionD-aspartateimportacrossplasmamembranedetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainGprotein-coupledreceptorsignalingpathwayinositolphosphatecatabolicprocessL-glutamateimportacrossplasmamembranelearningnegativeregulationofapoptoticprocessnegativeregulationofreleaseofsequesteredcalciumionintocytosolnegativeregulationofsystemicarterialbloodpressureneuropeptidesignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofarachidonicacidsecretionpositiveregulationofcationchannelactivitypositiveregulationofgamma-aminobutyricacidsecretionpositiveregulationofgeneexpressionpositiveregulationofglutamatesecretionpositiveregulationofinhibitorypostsynapticpotentialpositiveregulationofinositolphosphatebiosyntheticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofreleaseofsequesteredcalciumionintocytosolregulationofactionpotentialregulationofmembranedepolarizationregulationofrespiratorygaseousexchangeregulationofsensoryperceptionofpainresponsetolipidtemperaturehomeostasis
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
2.0
73
81
NDUB8X5BVZ3O95169X5BVZ3aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisATPsynthesiscoupledelectrontransport
RNA-binding protein 12
2.0
88
75
RBM12RBM12Q9NTZ6Q9NTZ6regulationofRNAsplicing
Interferon omega-1
2.0
59
84
IFNW1IFNW1P05000P05000adaptiveimmuneresponseBcelldifferentiationBcellproliferationcellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirushumoralimmuneresponsenaturalkillercellactivationinvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationofSTATproteinregulationofcellcycleresponsetoexogenousdsRNAresponsetovirusTcellactivationinvolvedinimmuneresponsetypeIinterferon-mediatedsignalingpathway
T-cell surface glycoprotein CD1e, membrane-associated
2.0
72
81
CD1ECD1EP15812P15812adaptiveimmuneresponseantigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbimmuneresponsepositiveregulationofTcellmediatedcytotoxicity
Light chain kappa
2.1
92
79
A0A125T908A0A125T908A0A125T908A0A125T908
Double-strand break repair protein MRE11
2.0
46
84
MRE11MRE11P49959P49959cellpopulationproliferationcellularresponsetoDNAdamagestimulusDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoininghomologouschromosomepairingatmeiosishomologousrecombinationmeioticDNAdouble-strandbreakformationmitochondrialdouble-strandbreakrepairviahomologousrecombinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/Mtransitioncheckpointmitoticintra-SDNAdamagecheckpointsignalingnegativeregulationofapoptoticprocesspositiveregulationofkinaseactivitypositiveregulationofproteinautophosphorylationpositiveregulationoftelomeremaintenancereciprocalmeioticrecombinationregulationofmitoticrecombinationsisterchromatidcohesiontelomeremaintenancetelomeremaintenanceviatelomerase"telomeric3overhangformation"
Exportin-5
2.0
77
85
✔
XPO5XPO5Q9HAV4Q9HAV4miRNAmetabolicprocesspositiveregulationofpost-transcriptionalgenesilencingbyRNApre-miRNAexportfromnucleusproteinexportfromnucleusRNAexportfromnucleus
Protein ERGIC-53
2.0
76
80
✔
LMAN1LMAN1Q62902Q62902endoplasmicreticulumorganizationendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationpositiveregulationoforganelleorganizationproteintransportsequesteringofmetalion
Ubiquitin-like protein ISG15
2.0
53
85
ISG15ISG15P05161P05161defenseresponsetobacteriumdefenseresponsetovirusintegrin-mediatedsignalingpathwayISG15-proteinconjugationmodification-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationnegativeregulationoftypeIinterferon-mediatedsignalingpathwaynegativeregulationofviralgenomereplicationpositiveregulationofbonemineralizationpositiveregulationoferythrocytedifferentiationpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofproteinoligomerizationpositiveregulationoftypeIIinterferonproductionproteinlocalizationtomitochondrionregulationoftypeIIinterferonproductionresponsetotypeIinterferonresponsetovirus
Set1/Ash2 histone methyltransferase complex subunit ASH2
3.4
49
84
ASH2LASH2LQ9UBL3Q9UBL3cellularresponsetoDNAdamagestimulushemopoiesishistoneH3-K4methylationpositiveregulationofcellpopulationproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIresponsetoestrogentranscriptioninitiation-coupledchromatinremodeling
Platelet glycoprotein 4
2.0
65
86
CD36CD36P16671P16671amyloidfibrilformationamyloid-betaclearancebycellularcatabolicprocessapoptoticcellclearancebloodcoagulationcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betacellularresponsetodiacylbacteriallipopeptidecellularresponsetohydroperoxidecellularresponsetolipopolysaccharidecellularresponsetolipoteichoicacidcellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetooxidisedlow-densitylipoproteinparticlestimuluscGMP-mediatedsignalingcholesterolimportcholesteroltransportdefenseresponsetoGram-positivebacteriumenergyhomeostasisfattyacidmetabolicprocessintestinalabsorptionintestinalcholesterolabsorptionlipidmetabolicprocesslipidstoragelipidtransportacrossblood-brainbarrierlipoproteintransportlong-chainfattyacidimportacrossplasmamembranelong-chainfattyacidimportintocelllong-chainfattyacidtransportlow-densitylipoproteinparticleclearancelow-densitylipoproteinparticlemediatedsignalingMAPKcascadenegativeregulationofgeneexpressionnegativeregulationofproteinimportintonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInitricoxidemediatedsignaltransductionoxidisedlow-densitylipoproteinparticleclearancephagocytosisengulfmentphagocytosisrecognitionplasmalipoproteinparticleclearancepositiveregulationofbloodcoagulationpositiveregulationofbloodmicroparticleformationpositiveregulationofcelldeathpositiveregulationofcell-matrixadhesionpositiveregulationofcholesterolstoragepositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphagocytosisengulfmentpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationoftumornecrosisfactorproductionproductionofmolecularmediatorinvolvedininflammatoryresponsereceptorinternalizationreceptor-mediatedendocytosisregulationofactionpotentialregulationoflipopolysaccharide-mediatedsignalingpathwayregulationofprotein-containingcomplexassemblyregulationofremovalofsuperoxideradicalsregulationoftoll-likereceptorsignalingpathwayresponsetofattyacidresponsetolinoleicacidresponsetolipidresponsetostilbenoidsensoryperceptionoftasteshort-chainfattyacidtransporttriglyceridetransport
Sodium/potassium-transporting ATPase subunit alpha-1
2.0
75
84
✔
AT1A1AT1A1P05023P05023cardiacmusclecellactionpotentialinvolvedincontractioncellcommunicationbyelectricalcouplinginvolvedincardiacconductioncellularpotassiumionhomeostasiscellularresponsetosteroidhormonestimuluscellularsodiumionhomeostasisestablishmentormaintenanceoftransmembraneelectrochemicalgradientmembranerepolarizationmembranerepolarizationduringcardiacmusclecellactionpotentialnegativeregulationofglucocorticoidbiosyntheticprocessnegativeregulationofheartcontractionpositiveregulationofheartcontractionpositiveregulationofstriatedmusclecontractionpotassiumionimportacrossplasmamembraneprotontransmembranetransportregulationofbloodpressureregulationofsodiumiontransportregulationoftheforceofheartcontractionrelaxationofcardiacmuscleresponsetoglycosideresponsetoxenobioticstimulussodiumionexportacrossplasmamembrane
Regulation of nuclear pre-mRNA domain-containing protein 1B
2.0
73
84
RPR1BRPR1BQ9NQG5Q9NQG5dephosphorylationofRNApolymeraseIIC-terminaldomain"mRNA3-endprocessing"positiveregulationofcellpopulationproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleprocess
Cholinergic receptor nicotinic alpha 1 subunit
2.0
66
85
G5E9G9G5E9G9G5E9G9G5E9G9
Fibroblast growth factor 2
2.0
74
80
FGF2FGF2P09038P09038agingangiogenesisinvolvedincoronaryvascularmorphogenesisanimalorganmorphogenesisbranchinginvolvedinuretericbudmorphogenesiscanonicalWntsignalingpathwaycelldifferentiationcellmigrationinvolvedinsproutingangiogenesiscellularresponsetomechanicalstimuluscerebellargranulecellprecursorproliferationchemotaxischondroblastdifferentiationcorticotropinhormonesecretingcelldifferentiationembryodevelopmentendinginbirthoregghatchingembryonicmorphogenesisendothelialcellproliferationERK1andERK2cascadefibroblastgrowthfactorreceptorsignalingpathwayglialcelldifferentiationgrowthfactordependentregulationofskeletalmusclesatellitecellproliferationhyaluronancatabolicprocessinnerearauditoryreceptorcelldifferentiationinositolphosphatebiosyntheticprocesslungdevelopmentlymphaticendothelialcellmigrationmammaryglandepithelialcelldifferentiationnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcelldeathnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwaynegativeregulationoffibroblastmigrationnegativeregulationofgeneexpressionnegativeregulationofstemcellproliferationnegativeregulationofwoundhealingnervoussystemdevelopmentneuroblastproliferationorganinductionosteoblastdifferentiationparacrinesignalingphosphatidylinositolbiosyntheticprocesspositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecellproliferationpositiveregulationofcelldivisionpositiveregulationofcellfatespecificationpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofcerebellargranulecellprecursorproliferationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellchemotaxispositiveregulationofendothelialcellchemotaxistofibroblastgrowthfactorpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofinnerearauditoryreceptorcelldifferentiationpositiveregulationoflensfibercelldifferentiationpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofneuroepithelialcelldifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseCactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofsproutingangiogenesispositiveregulationofstemcelldifferentiationpositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofvascularendothelialcellproliferationproteinkinaseBsignalingRasproteinsignaltransductionregulationofangiogenesisregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisregulationofcellcycleregulationofcellmigrationregulationofcellmigrationinvolvedinsproutingangiogenesisregulationofendothelialcellchemotaxistofibroblastgrowthfactorregulationofretinalcellprogrammedcelldeathreleaseofsequesteredcalciumionintocytosolresponsetoaxoninjurysignaltransductionstemcelldevelopmentstemcellproliferationsubstantianigradevelopmentthyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIwoundhealing
N-acetyltransferase ESCO1
4.6
47
80
ESCO1ESCO1Q5FWF5Q5FWF5mitoticsisterchromatidcohesionpeptidyl-lysineacetylationpost-translationalproteinacetylationregulationofDNAreplication
Cystatin-F
2.1
58
87
CYTFCYTFO76096O76096immuneresponseinhibitionofcysteine-typeendopeptidaseactivitynegativeregulationofmicroglialcellactivationnegativeregulationofpeptidaseactivitypositiveregulationofmyelination
Fibroblast growth factor 18
2.0
82
78
FGF18FGF18O76093O76093anatomicalstructuremorphogenesisangiogenesisanimalorganmorphogenesiscelldifferentiationcellpopulationproliferationcell-cellsignalingchondrocytedevelopmentendochondralossificationERK1andERK2cascadefibroblastgrowthfactorreceptorsignalingpathwayintramembranousossificationlungdevelopmentpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofendothelialcellchemotaxistofibroblastgrowthfactorpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofMAPkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofcellmigrationsignaltransductionvascularendothelialgrowthfactorreceptorsignalingpathway
Deoxyuridine 5'-triphosphate nucleotidohydrolase
2.0
75
82
A0A4X1SHL3A0A4X1SHL3A0A4X1SHL3A0A4X1SHL3dUMPbiosyntheticprocessdUTPcatabolicprocess
Hemojuvelin
2.0
53
87
RGMCRGMCQ6ZVN8Q6ZVN8activinreceptorsignalingpathwayBMPsignalingpathwaycellularironionhomeostasiscellularresponsetoBMPstimulusironionhomeostasisnegativeregulationofBMPsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIproteinautoprocessingtranscriptionbyRNApolymeraseII
E3 SUMO-protein ligase RanBP2
3.8
57
93
RBP2RBP2P49792P49792centrosomelocalizationmRNAtransportNLS-bearingproteinimportintonucleusnuclearexportnucleocytoplasmictransportpositiveregulationofglucokinaseactivityproteinfoldingproteinpeptidyl-prolylisomerizationproteinsumoylationregulationofgluconeogenesis
Gastric triacylglycerol lipase
2.0
59
85
LIPGLIPGP07098P07098lipidcatabolicprocessmalatemetabolicprocesstriglyceridemetabolicprocess
Protein shisa-3 homolog
2.1
52
86
SHSA3SHSA3Q3UPR0Q3UPR0negativeregulationofcanonicalWntsignalingpathway
Toll-like receptor 5
2.1
nan
90
TLR5TLR5O60602O60602cellularresponsetomechanicalstimulusinflammatoryresponseinnateimmuneresponsepositiveregulationofinterleukin-8productionpositiveregulationoftoll-likereceptorsignalingpathwaytoll-likereceptorsignalingpathway
C-C motif chemokine 14
2.0
75
81
CCL14CCL14Q16627Q16627cellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponselymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
MHC class I antigen
2.1
82
82
U6BN38U6BN38U6BN38U6BN38
Adhesion G-protein coupled receptor G4
2.0
50
86
AGRG4AGRG4Q8IZF6Q8IZF6adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathway
C-C chemokine receptor type 5
2.0
29
88
CCR5CCR5P51681P51681calciumiontransportcalcium-mediatedsignalingcellchemotaxiscellsurfacereceptorsignalingpathwaycell-cellsignalingcellulardefenseresponsecellularresponsetolipopolysaccharidechemotaxisdendriticcellchemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponseMAPKcascadepositiveregulationofcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolsignaling
Interleukin-22 receptor subunit alpha-2
2.0
72
83
I22R2I22R2Q08AH7Q08AH7cytokine-mediatedsignalingpathwaynegativeregulationofinflammatoryresponseregulationoftyrosinephosphorylationofSTATprotein
Zinc fingers and homeoboxes protein 2
2.0
64
83
ZHX2ZHX2Q9Y6X8Q9Y6X8mRNAcatabolicprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIretinalbipolarneurondifferentiationsomaticstemcellpopulationmaintenance
C-C motif chemokine 8
2.0
59
83
CCL8CCL8P80075P80075antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalciumiontransportcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiseosinophilchemotaxisexocytosisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationbyhostofviralgenomereplicationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivityresponsetovirussignaltransduction
DNA primase large subunit
2.1
83
79
PRI2PRI2P49643P49643DNAreplicationinitiationDNAreplicationsynthesisofRNAprimerpositiveregulationofDNAprimaseactivity
Ephrin type-B receptor 3
2.1
54
87
EPHB3EPHB3P54753P54753angiogenesisaxonguidanceaxonalfasciculationcellmigrationcentralnervoussystemprojectionneuronaxonogenesiscorpuscallosumdevelopmentdendriticspinedevelopmentdendriticspinemorphogenesisdigestivetractmorphogenesisephrinreceptorsignalingpathwaypositiveregulationofkinaseactivitypositiveregulationofsynapseassemblyproteinautophosphorylationregulationofaxonogenesisregulationofcell-celladhesionregulationofGTPaseactivityretinalganglioncellaxonguidanceroofofmouthdevelopmentsubstrateadhesion-dependentcellspreadingthymusdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathwayurogenitalsystemdevelopment
PRKCA-binding protein
2.1
69
83
PICK1PICK1Q9NRD5Q9NRD5cellularresponsetodecreasedoxygenlevelscellularresponsetoglucosestarvationdendriticspinemaintenancedendriticspineorganizationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationglialcelldevelopmentintracellularproteintransportlong-termsynapticdepressionmonoaminetransportnegativeregulationofArp2/3complex-mediatedactinnucleationneuronalionchannelclusteringpositiveregulationofreceptorinternalizationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationreceptorclusteringregulationofArp2/3complex-mediatedactinnucleationregulationofinsulinsecretionretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
UBX domain-containing protein 7
2.1
66
81
UBXN7UBXN7O94888O94888proteasome-mediatedubiquitin-dependentproteincatabolicprocess
Ras-related protein Rab-14
2.1
60
86
RAB14RAB14P61106P61106defenseresponsetobacteriumendocyticrecyclingfibroblastgrowthfactorreceptorsignalingpathwayGolgitoendosometransportintracellularproteintransportintracellulartransportphagolysosomeassemblyinvolvedinapoptoticcellclearancephagosomematurationregulationofembryonicdevelopmentregulationofproteinlocalizationvesicle-mediatedtransport
Zinc finger protein ZPR1
3.9
40
89
ZPR1ZPR1Q62384Q62384apoptoticprocessinvolvedindevelopmentaxondevelopmentCajalbodyorganizationcellpopulationproliferationcellularresponsetoepidermalgrowthfactorstimulusDNAendoreduplicationinnercellmasscellproliferationmicrotubulecytoskeletonorganizationmRNAprocessingnegativeregulationofmotorneuronapoptoticprocesspositiveregulationofcellcyclepositiveregulationofgeneexpressionpositiveregulationofgrowthpositiveregulationofproteinimportintonucleuspositiveregulationofRNAsplicingpositiveregulationoftranscriptioninvolvedinG1/Stransitionofmitoticcellcyclepre-mRNAcatabolicprocessregulationofmyelinationRNAsplicingspinalcorddevelopmenttrophectodermalcellproliferation
MAb 44B1 heavy chain
2.1
82
80
A0A0E4B366A0A0E4B366A0A0E4B366A0A0E4B366
Leukocyte immunoglobulin-like receptor subfamily B member 2
2.1
51
84
A0A0G2JNQ7A0A0G2JNQ7A0A0G2JNQ7A0A0G2JNQ7
Tissue factor pathway inhibitor (Lipoprotein-associated coagulation inhibitor) variant
2.1
61
86
Q59EE5Q59EE5Q59EE5Q59EE5bloodcoagulationnegativeregulationofpeptidaseactivity
Mitogen-activated protein kinase kinase kinase 9
2.1
60
81
M3K9M3K9P80192P80192apoptoticprocesspositiveregulationofapoptoticprocessproteinautophosphorylationproteinphosphorylation
RNA pseudouridylate synthase domain-containing protein 1
2.1
63
83
RUSD1RUSD1Q9UJJ7Q9UJJ7enzyme-directedrRNApseudouridinesynthesis
Adenylate kinase 2, mitochondrial
2.1
60
83
✔
KAD2KAD2P54819P54819ADPbiosyntheticprocessAMPmetabolicprocessATPmetabolicprocessnucleobase-containingsmallmoleculeinterconversionphosphorylation
Deoxyribonuclease TATDN1
2.1
65
78
✔
TATD1TATD1Q6P1N9Q6P1N9
C-X-C motif chemokine
2.1
72
83
Q0EAC1Q0EAC1Q0EAC1Q0EAC1immuneresponseinflammatoryresponse
Junctional adhesion molecule A
2.1
75
83
JAM1JAM1Q9Y624Q9Y624actomyosinstructureorganizationcell-celladhesioncellularresponsetomechanicalstimulusestablishmentofendothelialintestinalbarrierinflammatoryresponseintestinalabsorptionleukocytecell-celladhesionmaintenanceofblood-brainbarriermemoryTcellextravasationnegativeregulationofGTPaseactivitynegativeregulationofstressfiberassemblypositiveregulationofestablishmentofendothelialbarrierpositiveregulationofGTPaseactivitypositiveregulationofplateletaggregationpositiveregulationofRhoproteinsignaltransductionproteinlocalizationtobicellulartightjunctionproteinlocalizationtoplasmamembraneregulationofactincytoskeletonorganizationregulationofactincytoskeletonreorganizationregulationofbicellulartightjunctionassemblyregulationofcellshaperegulationofcytokineproductionregulationofcytoskeletonorganizationregulationofmembranepermeability
Interleukin-10 receptor subunit beta
2.0
60
83
I10R2I10R2Q08334Q08334cellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirusimmuneresponseinflammatoryresponsepositiveregulationofcellularrespirationpositiveregulationofreceptorsignalingpathwayviaJAK-STATsignaltransductiontypeIIIinterferon-mediatedsignalingpathway
Tripeptidyl-peptidase 1
2.1
54
86
TPP1TPP1O14773O14773boneresorptioncentralnervoussystemdevelopmentepithelialcelldifferentiationlipidmetabolicprocesslysosomalproteincatabolicprocesslysosomeorganizationnervoussystemdevelopmentneuromuscularprocesscontrollingbalancepeptidecatabolicprocessproteincatabolicprocessproteinlocalizationtochromosometelomericregionproteolysis
Serine/threonine-protein kinase 10
2.1
61
81
STK10STK10O94804O94804cellcyclelymphocyteaggregationproteinautophosphorylationproteinphosphorylationregulationoflymphocytemigration
Legumain
2.0
57
86
G3I1H5G3I1H5G3I1H5G3I1H5activationofcysteine-typeendopeptidaseactivityassociativelearningcellularresponsetoamyloid-betacellularresponsetocalciumioncellularresponsetohepatocytegrowthfactorstimulusdendriticspineorganizationmemorynegativeregulationofERBBsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofmulticellularorganismgrowthnegativeregulationofneuronapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellchemotaxispositiveregulationoflong-termsynapticpotentiationpositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotaxisproteolysisinvolvedinproteincatabolicprocessreceptorcatabolicprocessrenalsystemprocessresponsetoacidicpHselfproteolysis
Abasic site processing protein HMCES
2.1
68
80
✔
HMCESHMCESQ96FZ2Q96FZ2cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviaalternativenonhomologousendjoiningpositiveregulationofisotypeswitchingprotein-DNAcovalentcross-linkingproteolysis
Toll-like receptor 6
2.1
67
84
TLR6TLR6Q9Y2C9Q9Y2C9activationofNF-kappaB-inducingkinaseactivitycellularresponsetoamyloid-betacellularresponsetobacteriallipopeptidecellularresponsetodiacylbacteriallipopeptidecellularresponsetooxidisedlow-densitylipoproteinparticlestimulusdefenseresponsetobacteriumdetectionofdiacylbacteriallipopeptideimmuneresponseinflammatoryresponseinnateimmuneresponseMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofinterleukin-8productionnegativeregulationoftoll-likereceptor2signalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofJUNkinaseactivitypositiveregulationofmacrophageactivationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesssignaltransductiontoll-likereceptorsignalingpathwaytoll-likereceptorTLR6TRIF-dependenttoll-likereceptorsignalingpathway
Granulysin
2.1
64
85
GNLYGNLYP22749P22749antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellulardefenseresponsedefenseresponsetobacteriumdefenseresponsetofunguskillingofcellsofanotherorganism
Histone deacetylase complex subunit SAP18
2.1
41
85
SAP18SAP18O55128O55128mRNAprocessingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofmRNAsplicingviaspliceosomepositiveregulationofapoptoticprocessregulationofalternativemRNAsplicingviaspliceosomeregulationofDNA-templatedtranscriptionRNAsplicing
Deoxyribonuclease-1
3.1
24
88
DNAS1DNAS1P24855P24855apoptoticprocessDNAcatabolicprocessDNAcatabolicprocessendonucleolyticneutrophilactivationinvolvedinimmuneresponseregulationofacuteinflammatoryresponseregulationofneutrophilmediatedcytotoxicity
WD repeat and HMG-box DNA-binding protein 1
2.1
99
77
WDHD1WDHD1O75717O75717DNArepairDNA-templatedDNAreplicationmitoticcellcycle
Sorting nexin-11
2.1
75
84
SNX11SNX11Q9Y5W9Q9Y5W9intracellularproteintransportvesicleorganization
TRA@ protein
2.0
84
81
Q6NSA1Q6NSA1Q6NSA1Q6NSA1
Piwi-like protein 1
2.1
55
85
PIWL1PIWL1Q9JMB7Q9JMB7meioticcellcyclenegativeregulationoftranspositionpiRNAprocessingregulationoftranslationRNA-mediatedgenesilencingspermDNAcondensationspermatiddevelopmentspermatogenesis
SH3 and multiple ankyrin repeat domains protein 3
2.1
56
82
SHAN3SHAN3Q9BYB0Q9BYB0adultbehaviorAMPAglutamatereceptorclusteringbrainmorphogenesisdendriticspinemorphogenesisguanylatekinase-associatedproteinclusteringlearningMAPKcascadememorynegativeregulationofactinfilamentbundleassemblynegativeregulationofcellvolumeNMDAglutamatereceptorclusteringpositiveregulationofAMPAreceptoractivitypositiveregulationofdendriticspinedevelopmentpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofglutamatereceptorsignalingpathwaypositiveregulationoflong-termneuronalsynapticplasticitypositiveregulationoflong-termsynapticpotentiationpositiveregulationofsynapsestructuralplasticitypositiveregulationofsynaptictransmissionglutamatergicpostsynapticdensityassemblyregulationofdendriticspinemorphogenesisregulationoflong-termsynapticdepressionregulationoflong-termsynapticpotentiationsocialbehaviorstriatalmediumspinyneurondifferentiationsynapseassemblyvocallearningvocalizationbehavior
Platelet glycoprotein VI
2.1
75
84
GPVIGPVIQ9HCN6Q9HCN6collagen-activatedsignalingpathwayenzyme-linkedreceptorproteinsignalingpathwayplateletactivationpositiveregulationofplateletaggregation
ADP-ribosylation factor-binding protein GGA2
2.1
74
82
GGA2GGA2Q9UJY4Q9UJY4GolgitoplasmamembraneproteintransportGolgitoplasmamembranetransportintracellularproteintransportproteinlocalizationtocellsurface
Cadherin-23
2.1
92
77
CAD23CAD23Q99PF4Q99PF4auditoryreceptorcellstereociliumorganizationcalciumiontransportcalcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescelladhesioncell-celladhesionviaplasma-membraneadhesionmoleculesequilibrioceptionhomophiliccelladhesionviaplasmamembraneadhesionmoleculesinnerearauditoryreceptorcelldifferentiationinnereardevelopmentinnerearmorphogenesisinnerearreceptorcellstereociliumorganizationlocomotorybehaviorphotoreceptorcellmaintenancepost-embryonicanimalorganmorphogenesisregulationofcytosoliccalciumionconcentrationsensoryperceptionoflightstimulussensoryperceptionofsound
Ig-like domain-containing protein
2.1
66
83
Q6PIR9Q6PIR9Q6PIR9Q6PIR9
Thromboxane A2 receptor
3.8
52
85
TA2RTA2RP21731P21731adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetolipopolysaccharideGprotein-coupledreceptorsignalingpathwayinflammatoryresponsenegativeregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofangiogenesispositiveregulationofbloodcoagulationpositiveregulationofbloodpressurepositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofsmoothmusclecontractionpositiveregulationofvasoconstrictionresponsetoethanolresponsetonutrientresponsetotestosteroneresponsetoxenobioticstimulussecond-messenger-mediatedsignalingsmoothmusclecontraction
Torsin-1A-interacting protein 2
2.1
56
83
TOIP2TOIP2Q8NFQ8Q8NFQ8endoplasmicreticulumorganizationmembraneorganizationpositiveregulationofATP-dependentactivityproteinlocalizationtonuclearenvelope
Glycine receptor subunit alpha-3
2.1
68
84
GLRA3GLRA3O75311O75311chemicalsynaptictransmissionchloridetransmembranetransportiontransmembranetransportnervoussystemprocessneuropeptidesignalingpathwayproteinhomooligomerizationregulationofmembranepotentialresponsetoaminoacidsignaltransductionsynaptictransmissionglycinergic
ADP-ribosylation factor GTPase-activating protein 1
2.1
33
86
ARFG1ARFG1Q8N6T3Q8N6T3proteintransportregulationofARFproteinsignaltransductionregulationofendocytosisvesicle-mediatedtransport
C-type lectin domain family 9 member A
2.0
56
85
CLC9ACLC9AQ6UXN8Q6UXN8positiveregulationofcytokineproductionreceptor-mediatedendocytosis
Titin
2.1
72
83
TITINTITINQ10466Q10466cardiacmusclecelldevelopmentcardiacmusclecontractioncardiacmusclehypertrophycardiacmuscletissuemorphogenesiscardiacmyofibrilassemblydetectionofmusclestretchmitoticchromosomecondensationmusclecontractionpositiveregulationofgeneexpressionpositiveregulationofproteinsecretionproteinkinaseAsignalingregulationofcatalyticactivityregulationofproteinkinaseactivityresponsetocalciumionsarcomereorganizationsarcomerogenesisskeletalmusclemyosinthickfilamentassemblyskeletalmusclethinfilamentassemblystriatedmusclecontraction
HLA class I histocompatibility antigen
2.1
82
82
Q95J06Q95J06Q95J06Q95J06antigenprocessingandpresentationimmuneresponse
Natural cytotoxicity triggering receptor 3
2.1
79
81
NCTR3NCTR3O14931O14931cellrecognitionimmuneresponseimmuneresponse-activatingcellsurfacereceptorsignalingpathwayinflammatoryresponsenaturalkillercellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicity
Cadherin-17
2.1
60
86
CAD17CAD17Q12864Q12864calcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescelladhesioncell-celladhesionviaplasma-membraneadhesionmoleculesgerminalcenterBcelldifferentiationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesintegrin-mediatedsignalingpathwaymarginalzoneBcelldifferentiationoligopeptidetransmembranetransportoligopeptidetransportpositiveregulationofintegrinactivationbycellsurfacereceptorlinkedsignaltransductionspleendevelopment
Receptor-type tyrosine-protein phosphatase epsilon
2.1
48
84
PTPREPTPREP23469P23469negativeregulationofinsulinreceptorsignalingpathwayproteindephosphorylation
Filamin-C
3.0
59
79
FLNCFLNCQ14315Q14315sarcomereorganization
Potassium channel subfamily K member 4
2.1
85
81
KCNK4KCNK4Q9NYG8Q9NYG8cellularresponsetoalkalinepHcellularresponsetofattyacidcellularresponsetomechanicalstimuluscellularresponsetotemperaturestimulusdetectionofmechanicalstimulusinvolvedinsensoryperceptionoftouchmemorypotassiumiontransmembranetransportpotassiumiontransportregulationofiontransmembranetransportsensoryperceptionofpainsensoryperceptionoftemperaturestimulusstabilizationofmembranepotential
Tumor suppressor candidate 3
2.0
49
90
TUSC3CRBNQ13454Q96SW2cognitionmagnesiumiontransportproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparaginetransmembranetransportlocomotoryexplorationbehaviornegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblypositiveregulationofWntsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
DNA ligase 4
2.1
73
83
DNLI4DNLI4P49917P49917cellcyclecelldivisioncellpopulationproliferationcellularresponsetoionizingradiationcellularresponsetolithiumioncentralnervoussystemdevelopmentchromosomeorganizationDN2thymocytedifferentiationDNAbiosyntheticprocessDNAligationDNAligationinvolvedinDNArecombinationDNAligationinvolvedinDNArepairDNAreplicationdouble-strandbreakrepairdouble-strandbreakrepairviaclassicalnonhomologousendjoiningdouble-strandbreakrepairvianonhomologousendjoiningestablishmentofintegratedprovirallatencyfibroblastproliferationimmunoglobulinV(D)Jrecombinationinuteroembryonicdevelopmentisotypeswitchingnegativeregulationofneuronapoptoticprocessneurogenesisneuronapoptoticprocessnucleotide-excisionrepairDNAgapfillingpositiveregulationofchromosomeorganizationpositiveregulationoffibroblastproliferationpositiveregulationofneurogenesispro-BcelldifferentiationresponsetogammaradiationresponsetoX-raysinglestrandbreakrepairsomaticstemcellpopulationmaintenancestemcellproliferationTcelldifferentiationinthymusTcellreceptorV(D)JrecombinationV(D)Jrecombination
Interferon alpha-2
2.1
nan
87
IFNA2IFNA2P01563P01563adaptiveimmuneresponseapoptoticprocessBcelldifferentiationBcellproliferationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetoviruscytokine-mediatedsignalingpathwaydefenseresponsetovirushumoralimmuneresponseinflammatoryresponsenaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationofinterleukin-13productionnegativeregulationofinterleukin-5productionnegativeregulationofTcelldifferentiationnegativeregulationofT-helper2cellcytokineproductionnegativeregulationofviralentryintohostcellpositiveregulationofpeptidyl-serinephosphorylationofSTATproteinpositiveregulationoftyrosinephosphorylationofSTATproteinresponsetoexogenousdsRNATcellactivationinvolvedinimmuneresponsetypeIinterferon-mediatedsignalingpathway
Biliary glycoprotein
2.1
80
81
Q61354Q61354Q61354Q61354
Transmembrane emp24 domain-containing protein 2
2.1
63
82
TMED2TMED2Q15363Q15363allantoisdevelopmentbranchinginvolvedinlabyrinthinelayermorphogenesischoriondevelopmentCOPIcoatingofGolgivesicleCOPIIvesiclecoatingendoplasmicreticulummembraneorganizationendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationheartloopingintracellularproteintransportlabyrinthinelayerbloodvesseldevelopmentmaternalplacentadevelopmentmulticellularorganismgrowthnegativeregulationofendoplasmicreticulumstress-inducedeIF2alphaphosphorylationnegativeregulationofGTPaseactivityneuraltubeclosurePERK-mediatedunfoldedproteinresponsepositiveregulationofgeneexpressionpost-analtailmorphogenesisproteinlocalizationtoplasmamembraneregulationofSREBPsignalingpathwaysomiterostral/caudalaxisspecificationvesiclecargoloading
Bromodomain adjacent to zinc finger domain protein 2B
3.6
49
88
BAZ2BBAZ2BQ9UIF8Q9UIF8chromatinremodelingregulationoftranscriptionbyRNApolymeraseII
Ephrin type-B receptor 4
2.1
63
86
EPHB4EPHB4P54760P54760angiogenesisaxonguidancecelladhesioncellmigrationinvolvedinsproutingangiogenesisephrinreceptorsignalingpathwayheartmorphogenesispositiveregulationofkinaseactivityproteinautophosphorylationtransmembranereceptorproteintyrosinekinasesignalingpathway
Sodium channel subunit beta-4
2.1
38
86
SCN4BSCN4BQ8IWT1Q8IWT1AVnodecellactionpotentialcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionestablishmentoflocalizationincellmembranedepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofsodiumiontransportregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranerepolarizationsodiumiontransmembranetransportsodiumiontransport
LIR-1
2.0
47
85
D9IDM8D9IDM8D9IDM8D9IDM8
NT-3 growth factor receptor
2.1
46
84
NTRK3NTRK3Q16288Q16288activationofGTPaseactivityactivationofproteinkinaseBactivitycellularresponsetonervegrowthfactorstimuluscellularresponsetoretinoicacidcochleadevelopmentheartdevelopmentnegativeregulationofastrocytedifferentiationnegativeregulationofcelldeathnegativeregulationofproteinphosphorylationneuronfatespecificationneuronmigrationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofpositivechemotaxispositiveregulationofproteinphosphorylationpostsynapticdensityassemblyregulationofpresynapseassemblyregulationofproteinkinaseBsignalingresponsetoaxoninjuryresponsetocorticosteroneresponsetoethanoltransmembranereceptorproteintyrosinekinasesignalingpathway
Low affinity immunoglobulin gamma Fc region receptor II-c
2.0
74
84
FCG2CFCG2CP31995P31995cellsurfacereceptorsignalingpathwayimmuneresponseregulationofimmuneresponse
CD1D antigen, d polypeptide
2.1
78
80
A1L565A1L565A1L565A1L565
C-type lectin domain family 4, member a4
2.1
51
85
Q5YIR8Q5YIR8Q5YIR8Q5YIR8antifungalinnateimmuneresponseimmuneresponse
HLA class I antigen
2.1
81
82
Q53Z42Q53Z42Q53Z42Q53Z42antigenprocessingandpresentationimmuneresponse
MHC class I antigen
2.1
82
82
B1PJV3B1PJV3B1PJV3B1PJV3antigenprocessingandpresentationimmuneresponse
Histone-lysine N-methyltransferase PRDM9
3.3
38
91
PRDM9PRDM9Q9NQV7Q9NQV7chromatinorganizationdouble-strandbreakrepairinvolvedinmeioticrecombinationfemalegametegenerationhistonemethylationhomologouschromosomepairingatmeiosismalegametegenerationmeioticgeneconversionnegativeregulationofapoptoticprocesspositiveregulationoffertilizationpositiveregulationofreciprocalmeioticrecombinationregulationofDNA-templatedtranscriptionregulationofgeneexpression
Antileukoproteinase
2.1
50
87
SLPISLPIP03973P03973antibacterialhumoralresponseimmuneresponseinnateimmuneresponsemodulationofprocessofanotherorganismnegativeregulationofpeptidaseactivitynegativeregulationofproteinbindingnegativeregulationofviralgenomereplicationresponsetolipopolysaccharide
Glycodelin
2.0
nan
91
PAEPPAEPP09466P09466apoptoticprocessnegativeregulationofspermcapacitationpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionregulationofbindingofspermtozonapellucida
Torsin-1A-interacting protein 1
2.1
57
83
TOIP1TOIP1Q5JTV8Q5JTV8membraneorganizationnuclearmembraneorganizationpositiveregulationofATP-dependentactivityproteinlocalizationtonuclearenvelopeproteinlocalizationtonucleus
Cobalamin binding intrinsic factor
2.0
52
87
IFIFP27352P27352cobalamintransportcobaltiontransport
HLA class I histocompatibility antigen A alpha chain
2.1
82
82
Q5MAG5Q5MAG5Q5MAG5Q5MAG5antigenprocessingandpresentationimmuneresponse
MHC class I antigen
2.0
61
83
F6IQS2F6IQS2F6IQS2F6IQS2
Anti-F4+ETEC bacteria VHH variable region
2.1
81
80
R9W3F6R9W3F6R9W3F6R9W3F6
Leptin receptor
2.1
nan
88
LEPRLEPRP48357P48357angiogenesisbonegrowthcellsurfacereceptorsignalingpathwaycholesterolmetabolicprocesscytokine-mediatedsignalingpathwayenergyhomeostasisenergyreservemetabolicprocessglialcellproliferationgluconeogenesisglucosehomeostasisglycogenmetabolicprocessleptin-mediatedsignalingpathwaymulticellularorganismdevelopmentnegativeregulationofautophagynegativeregulationofgluconeogenesisnegativeregulationofhydrolaseactivityphagocytosispositiveregulationofcold-inducedthermogenesispositiveregulationofproteinphosphorylationregulationofboneremodelingregulationoffeedingbehaviorregulationoftransportresponsetoleptinsexualreproductionTcelldifferentiationtransportacrossblood-brainbarrier
Integrator complex subunit 11
2.1
57
82
INT11INT11Q5TA45Q5TA45regulationoftranscriptionelongationbyRNApolymeraseIIsnRNAprocessing
cDNA FLJ56608, highly similar to Homo sapiens chloride channel, calcium activated, family member 1 (CLCA1), mRNA
2.1
63
82
B4DUZ6B4DUZ6B4DUZ6B4DUZ6proteolysis
Anti-RhD monoclonal T125 gamma1 heavy chain
2.1
87
79
Q5EFE5Q5EFE5Q5EFE5Q5EFE5
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
3.8
50
90
✔
NGLY1NGLY1Q9JI78Q9JI78ER-associatedmisfoldedproteincatabolicprocessglycoproteincatabolicprocessproteindeglycosylationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteins
Transmembrane emp24 domain-containing protein 1
2.1
65
80
TMED1TMED1Q13445Q13445cell-cellsignalingendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationinnateimmuneresponseintracellularproteintransportsignaltransduction
Major prion protein
2.1
87
80
Q9TSF8Q9TSF8Q9TSF8Q9TSF8proteinhomooligomerization
D(4) dopamine receptor
2.1
31
87
DRD4DRD4P21917P21917adenylatecyclase-inhibitingdopaminereceptorsignalingpathwayadultlocomotorybehaviorarachidonicacidsecretionbehavioralfearresponsebehavioralresponsetococainebehavioralresponsetoethanolcellularcalciumionhomeostasischemicalsynaptictransmissiondopaminemetabolicprocessdopaminereceptorsignalingpathwayfearresponseGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerinhibitorypostsynapticpotentialnegativeregulationofproteinsecretionnegativeregulationofvoltage-gatedcalciumchannelactivitypositiveregulationofdopamineuptakeinvolvedinsynaptictransmissionpositiveregulationofkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofsodiumregulationofcircadianrhythmregulationofdopaminemetabolicprocessregulationofpostsynapticneurotransmitterreceptorinternalizationresponsetoamphetamineresponsetohistaminerhythmicprocesssocialbehavior
MHC class I antigen
2.1
81
82
Q8MHU4Q8MHU4Q8MHU4Q8MHU4antigenprocessingandpresentationimmuneresponse
Carbonic anhydrase 6
2.1
63
84
CAH6CAH6P23280P23280detectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteone-carbonmetabolicprocess
SUN domain-containing protein 1
2.1
50
83
SUN1SYNE1O94901Q8NF91centrosomelocalizationhomologouschromosomepairingatmeiosismeioticattachmentoftelomeretonuclearenvelopenuclearenvelopeorganizationnuclearmatrixanchoringatnuclearmembranenucleokinesisinvolvedincellmotilityincerebralcortexradialgliaguidedmigrationspermatogenesisGolgiorganizationmusclecelldifferentiationnucleusorganization
Potassium channel subfamily K member 1
2.1
44
84
KCNK1KCNK1O00180O00180potassiumiontransmembranetransportpotassiumiontransportregulationofrestingmembranepotentialresponsetonicotinesodiumiontransmembranetransportstabilizationofmembranepotential
Cysteine-rich secretory protein 2
2.0
33
90
CRIS2CRIS2P16563P16563cell-celladhesion
Solute carrier family 7 member 9
2.1
54
82
A0A6P3EL78A0A6P7DVK7A0A6P3EL78A0A6P7DVK7carbohydratemetabolicprocess
C-X-C motif chemokine 2
2.0
64
85
CXCL2CXCL2P19875P19875antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaychemotaxisinflammatoryresponsekillingofcellsofanotherorganismneutrophilchemotaxisresponsetomoleculeofbacterialorigin
Neuropilin-1
2.1
55
88
NRP1NRP1P97333P97333actincytoskeletonreorganizationangiogenesisangiogenesisinvolvedincoronaryvascularmorphogenesisarterymorphogenesisaxonextensionaxonextensioninvolvedinaxonguidanceaxonguidanceaxonalfasciculationaxonogenesisinvolvedininnervationbasaldendritearborizationbasaldendritedevelopmentbloodvesselendothelialcellmigrationbranchinginvolvedinbloodvesselmorphogenesisbranchiomotorneuronaxonguidancecellmigrationinvolvedincoronaryvasculogenesiscellmigrationinvolvedinsproutingangiogenesiscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetovascularendothelialgrowthfactorstimuluscommissuralneuronaxonguidancecoronaryarterymorphogenesisdendritedevelopmentdichotomoussubdivisionofterminalunitsinvolvedinsalivaryglandbranchingdorsalrootganglionmorphogenesisendothelialcellchemotaxisendothelialcellmigrationfacialnervestructuralorganizationfacioacousticgangliondevelopmentgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamusheartdevelopmenthepatocytegrowthfactorreceptorsignalingpathwayintegrin-mediatedsignalingpathwaymotorneuronaxonguidancemotorneuronmigrationnegativeregulationofaxonextensionnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnervedevelopmentneuralcrestcellmigrationneuralcrestcellmigrationinvolvedinautonomicnervoussystemdevelopmentneurondevelopmentneuronmigrationneuropilinsignalingpathwayoticplacodedevelopmentoutflowtractseptummorphogenesisplatelet-derivedgrowthfactorreceptorsignalingpathwaypositivechemotaxispositiveregulationofactincytoskeletonreorganizationpositiveregulationofangiogenesispositiveregulationofaxonextensioninvolvedinaxonguidancepositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofendothelialcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationoffilopodiumassemblypositiveregulationoffocaladhesionassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofretinalganglioncellaxonguidancepositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpostsynapseorganizationproteinlocalizationtoearlyendosomeregulationofaxonextensioninvolvedinaxonguidanceregulationofCdc42proteinsignaltransductionregulationofretinalganglioncellaxonguidanceregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayrenalarterymorphogenesisresponsetowoundingretinavasculaturemorphogenesisincamera-typeeyeretinalganglioncellaxonguidancesemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesemaphorin-plexinsignalingpathwayinvolvedinneuronprojectionguidancesensoryneuronaxonguidancesproutingangiogenesissubstrateadhesion-dependentcellspreadingsubstrate-dependentcellmigrationcellextensionsympatheticgangliondevelopmentsympatheticnervoussystemdevelopmentsympatheticneuronprojectionextensionsympatheticneuronprojectionguidancetoxintransporttrigeminalgangliondevelopmenttrigeminalnervemorphogenesistrigeminalnervestructuralorganizationvascularendothelialgrowthfactorreceptorsignalingpathwayvasculogenesisVEGF-activatedneuropilinsignalingpathwayVEGF-activatedneuropilinsignalingpathwayinvolvedinaxonguidanceventraltrunkneuralcrestcellmigrationvestibulocochlearnervestructuralorganizationviralentryintohostcell
Xanthine dehydrogenase/oxidase
2.1
59
83
XDHXDHP47989P47989activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessadenosinecatabolicprocessallantoinmetabolicprocessamidecatabolicprocessAMPcatabolicprocessdAMPcatabolicprocessdeoxyadenosinecatabolicprocessdeoxyguanosinecatabolicprocessdeoxyinosinecatabolicprocessdGMPcatabolicprocessGMPcatabolicprocessguaninecatabolicprocesshypoxanthinecatabolicprocessIMPcatabolicprocessinosinecatabolicprocessiron-sulfurclusterassemblylactationnegativeregulationofendothelialcelldifferentiationnegativeregulationofendothelialcellproliferationnegativeregulationofgeneexpressionnegativeregulationofproteinkinaseBsignalingnegativeregulationofproteinphosphorylationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaynegativeregulationofvasculogenesispositiveregulationofp38MAPKcascadepositiveregulationofreactiveoxygenspeciesmetabolicprocessxanthinecatabolicprocess
Migration and invasion enhancer 1
2.1
40
85
✔
MIEN1MIEN1Q9BRT3Q9BRT3apoptoticprocessnegativeregulationofapoptoticprocesspositiveregulationofcellmigrationpositiveregulationoffilopodiumassemblyresponsetoseleniumion
Switch-associated protein 70
2.1
52
87
SWP70SWP70Q9UH65Q9UH65actinfilamentbundleassemblyisotypeswitchingnegativeregulationofactinfilamentdepolymerizationnegativeregulationofcell-celladhesionmediatedbyintegrinnegativeregulationofpeptidyl-serinedephosphorylationpositiveregulationofactinfilamentbundleassemblypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofmastcellchemotaxisregulationofproteinlocalizationregulationofsmallGTPasemediatedsignaltransduction
MHC class I antigen
2.1
53
85
A0A109QAI7A0A109QAI7A0A109QAI7A0A109QAI7antigenprocessingandpresentationimmuneresponse
glutaminyl-peptide cyclotransferase
2.1
100
74
B2RX76B2RX76B2RX76B2RX76
MHC class I antigen
2.2
82
82
A0A0B7MGD5A0A0B7MGD5A0A0B7MGD5A0A0B7MGD5antigenprocessingandpresentationimmuneresponse
Cell adhesion molecule 2
2.1
82
81
CADM2CADM2Q8BLQ9Q8BLQ9braindevelopmenthomophiliccelladhesionviaplasmamembraneadhesionmolecules
Dynamin-3
2.1
69
80
DYN3DYN3Q9UQ16Q9UQ16endocytosisfilopodiumassemblynegativeregulationofdendriticspinemorphogenesispositiveregulationoffilopodiumassemblypositiveregulationofsynapticvesiclerecyclingpostsynapticneurotransmitterreceptorinternalizationreceptorinternalizationsynapseassemblysynapticvesicleendocytosis
Protein OS-9
2.1
54
87
OS9OS9Q13438Q13438endoplasmicreticulumunfoldedproteinresponsenegativeregulationofretrogradeproteintransportERtocytosolproteinretentioninERlumenproteintargetingproteinubiquitinationresponsetoendoplasmicreticulumstressretrogradeproteintransportERtocytosolubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocess
Sorting nexin-32
2.1
54
82
SNX32SNX32Q86XE0Q86XE0proteintransportregulationofmacroautophagyretrogradetransportendosometoGolgi
Protein Spindly
2.1
48
84
SPDLYSPDLYQ96EA4Q96EA4celldivisioncellmigrationestablishmentofmitoticspindleorientationmitoticmetaphaseplatecongressionmitoticspindleassemblycheckpointsignalingproteinlocalizationtokinetochore
Thioredoxin reductase 2, mitochondrial
2.1
71
79
TRXR2TRXR2Q9JLT4Q9JLT4cellredoxhomeostasisheartdevelopmenthemopoiesisresponsetooxygenradical
Netrin receptor UNC5B
2.1
48
88
UNC5BUNC5BQ8K1S3Q8K1S3angiogenesisanterior/posterioraxonguidanceapoptoticprocessaxonguidancenegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofneuronapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationofphosphatidylinositol3-kinasesignaling
Granulocyte colony-stimulating factor receptor
2.1
nan
89
CSF3RCSF3RQ99062Q99062celladhesioncytokine-mediatedsignalingpathwaydefenseresponseneutrophilchemotaxisregulationofmyeloidcelldifferentiationsignaltransduction
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
2.1
63
81
✔
MALT1MALT1Q9UDY8Q9UDY8activationofNF-kappaB-inducingkinaseactivityBcellactivationB-1Bcelldifferentiationdefenseresponseinnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaynegativeregulationofapoptoticprocessnuclearexportpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-2productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinubiquitinationpositiveregulationofTcellcytokineproductionpositiveregulationofT-helper17celldifferentiationproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofapoptoticprocessregulationofTcellreceptorsignalingpathwayresponsetofungusTcellproliferationTcellreceptorsignalingpathway
Caspase-2
2.1
81
74
✔
CASP2CASP2P42575P42575activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessagingapoptoticprocessapoptoticsignalingpathwaybraindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestectopicgermcellprogrammedcelldeathexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageluteolysisnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessneuralretinadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofneuronapoptoticprocessproteinprocessingregulationofDNAstabilityreleaseofcytochromecfrommitochondria
Beta-crystallin A4
2.1
64
81
CRBA4CRBA4P53673P53673camera-typeeyedevelopmentlensdevelopmentincamera-typeeyevisualperception
Guanylin
2.1
nan
91
GUC2AGUC2AQ02747Q02747
Chromobox protein homolog 3
2.1
85
82
CBX3CBX3Q13185Q13185cellularresponsetoDNAdamagestimuluschromatinorganizationchromatinremodelingheterochromatinformationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIrhythmicprocess
Replication protein A 32 kDa subunit
2.1
76
82
RFA2RFA2P15927P15927base-excisionrepairDNAreplicationdouble-strandbreakrepairviahomologousrecombinationmismatchrepairmitoticG1DNAdamagecheckpointsignalingnucleotide-excisionrepairproteinlocalizationtochromosomeregulationofDNAdamagecheckpointregulationofdouble-strandbreakrepairviahomologousrecombinationtelomeremaintenance
Carboxylic ester hydrolase
2.2
52
84
A9GYW6A9GYW6A9GYW6A9GYW6
Adrenocorticotropic hormone receptor
2.0
63
84
ACTHRACTHRQ01718Q01718adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerregulationofmetabolicprocess
Neurotrypsin
2.1
52
88
NETRNETRO08762O08762exocytosisproteolysiszymogenactivation
Alpha-1-acid glycoprotein 1
2.0
40
87
A1AG1A1AG1P02763P02763acute-phaseresponseinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationoftumornecrosisfactorproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-1productionpositiveregulationoftumornecrosisfactorproductionregulationofimmunesystemprocess
Fibronectin
3.1
nan
88
B7ZLE5B7ZLE5B7ZLE5B7ZLE5acute-phaseresponsecelladhesionregulationofcellshape
Tripartite motif-containing protein 67
2.2
71
80
TRI67TRI67Q6ZTA4Q6ZTA4negativeregulationofRasproteinsignaltransductionpositiveregulationofneuronprojectiondevelopmentpositiveregulationofubiquitin-dependentproteincatabolicprocessregulationofproteinlocalization
MHC class II antigen
2.0
80
80
Q5SU54Q5SU54Q5SU54Q5SU54adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Protocadherin related 15
2.2
50
86
A0A087X1T6A0A087X1T6A0A087X1T6A0A087X1T6homophiliccelladhesionviaplasmamembraneadhesionmoleculesinnereardevelopmentsensoryperceptionofsound
Kunitz-type protease inhibitor 2
2.0
nan
90
SPIT2SPIT2O43291O43291basementmembraneorganizationcellularresponsetoBMPstimulusepithelialcellmorphogenesisinvolvedinplacentalbranchingestablishmentormaintenanceofcellpolaritynegativeregulationofcellmotilitynegativeregulationofcell-celladhesionnegativeregulationofneuralprecursorcellproliferationnegativeregulationofpeptidaseactivityneuraltubeclosure
C-C motif chemokine 13
2.2
74
80
CCL13CCL13Q99616Q99616antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivityregulationofcellshapesignaltransduction
Chloride intracellular channel protein 2
2.2
74
79
✔
CLIC2CLIC2O15247O15247chloridetransportnegativeregulationofryanodine-sensitivecalcium-releasechannelactivitypositiveregulationofbindingregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumsignaltransduction
Sorting nexin-10
2.2
69
78
SNX10SNX10Q9Y5X0Q9Y5X0bonemineralizationinvolvedinbonematurationboneresorptioncalciumionhomeostasiscellularhomeostasiscellularresponsetoleukemiainhibitoryfactorciliumassemblyendocytosisendosomeorganizationgastricacidsecretionintracellularproteintransportosteoclastdifferentiationproteinlocalizationtocentrosomeproteinlocalizationtociliumruffleassemblytootheruptionvesicleorganization
ERO1-like protein alpha
2.0
nan
94
ERO1AERO1AQ96HE7Q96HE7brownfatcelldifferentiationcellredoxhomeostasiscellularresponsetohypoxiachaperonecofactor-dependentproteinrefoldingendoplasmicreticulumunfoldedproteinresponseextracellularmatrixorganizationinsulinprocessingintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresspeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinfoldingproteinfoldinginendoplasmicreticulumproteinmaturationbyproteinfoldingproteinmodificationprocessreleaseofsequesteredcalciumionintocytosolresponsetoendoplasmicreticulumstressresponsetooxidativestressresponsetotemperaturestimulus
Isoform 2 of Transmembrane protein 266
2.2
68
82
TM266TM266Q8BZB3-2Q8BZB3-2
Tudor domain-containing protein 1
2.2
68
81
TDRD1TDRD1Q9BXT4Q9BXT4DNAmethylationinvolvedingametegenerationgermcelldevelopmentmeioticcellcyclePgranuleorganizationpiRNAprocessingRNA-mediatedgenesilencingspermatogenesis
Histone acetyltransferase p300
4.0
39
90
EP300EP300Q09472Q09472animalorganmorphogenesisapoptoticprocessBcelldifferentiationbehavioraldefenseresponsecellcyclecellularresponsetoUVcircadianrhythmfacemorphogenesisfatcelldifferentiationheartdevelopmenthistoneacetylationinternalpeptidyl-lysineacetylationinternalproteinaminoacidacetylationintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorlearningormemorylungdevelopmentmacrophagederivedfoamcelldifferentiationmegakaryocytedevelopmentmulticellularorganismgrowthN-terminalpeptidyl-lysineacetylationnegativeregulationofgluconeogenesisnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpeptidyl-lysineacetylationpeptidyl-lysinebutyrylationpeptidyl-lysinecrotonylationpeptidyl-lysinepropionylationplateletformationpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofproteinbindingpositiveregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbindingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationproteinstabilizationregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofcellularresponsetoheatregulationofglycolyticprocessregulationofmitochondrionorganizationregulationofsignaltransductionbyp53classmediatorregulationoftubulindeacetylationresponsetoestrogenresponsetohypoxiaskeletalmuscletissuedevelopmentsomitogenesisstimulatoryC-typelectinreceptorsignalingpathwayswimmingthigmotaxistranscriptionbyRNApolymeraseIItranscriptioninitiation-coupledchromatinremodeling
Zinc finger protein 276
2.8
52
88
A0A5F9DAT3A0A5F9DAT3A0A5F9DAT3A0A5F9DAT3
Major prion protein
2.3
85
81
O97964O97964O97964O97964proteinhomooligomerization
GATOR complex protein MIOS
3.1
64
93
MIOMIOQ9NXC5Q9NXC5cellularresponsetoaminoacidstarvationnegativeregulationofTORC1signalingpositiveregulationofTORsignalingpositiveregulationofTORC1signalingprotein-containingcomplexlocalization
Mothers against decapentaplegic homolog 3
2.5
64
80
SMAD3SMAD3P84022P84022activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesiscelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofDNA-templatedtranscriptionregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealing
DNA-directed RNA polymerase II subunit RPB9
3.0
53
92
RPB9RPB9P36954P36954maintenanceoftranscriptionalfidelityduringtranscriptionelongationbyRNApolymeraseIImRNAcleavagetranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromotertranscription-couplednucleotide-excisionrepair
Fibroblast growth factor 8
2.5
83
79
FGF8FGF8P55075P55075anatomicalstructuremorphogenesisanimalorganmorphogenesisaortamorphogenesisbloodvesselremodelingbonedevelopmentbranchinginvolvedinbloodvesselmorphogenesisbranchinginvolvedinsalivaryglandmorphogenesisbranchinginvolvedinuretericbudmorphogenesiscelldifferentiationcellfatecommitmentcellmigrationinvolvedinmesendodermmigrationcellproliferationinforebraincorticotropinhormonesecretingcelldifferentiationdopaminergicneurondifferentiationdorsal/ventralpatternformationembryonichearttubedevelopmentembryonichindlimbmorphogenesisembryonicneurocraniummorphogenesisepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationfibroblastgrowthfactorreceptorsignalingpathwayforebraindorsal/ventralpatternformationforebrainmorphogenesisgastrulationgonaddevelopmentheartloopingheartmorphogenesislarynxmorphogenesislimbmorphogenesislungmorphogenesismalegenitaliadevelopmentMAPKcascademesodermalcellmigrationmesonephrosdevelopmentmetanephrosdevelopmentmidbrain-hindbrainboundarydevelopmentmitoticnucleardivisionnegativeregulationofcardiacmuscletissuedevelopmentnegativeregulationofneuronapoptoticprocessneuralplatemorphogenesisneuroepithelialcelldifferentiationneuronapoptoticprocessneurondifferentiationodontogenesisorgangrowthorganinductionoticvesicleformationoutflowtractseptummorphogenesispalliumdevelopmentpharyngealsystemdevelopmentpositiveregulationofcelldifferentiationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofmitoticnucleardivisionpositiveregulationoforgangrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofstemcellproliferationregulationofcellmigrationregulationofodontogenesisofdentin-containingtoothsignaltransductioninvolvedinregulationofgeneexpressionstemcellproliferationsubpalliumdevelopmentthyroidglanddevelopmentthyroid-stimulatinghormone-secretingcelldifferentiation
Palmitoyltransferase ZDHHC20
2.6
66
94
ZDH20ZDH20Q5W0Z9Q5W0Z9peptidyl-L-cysteineS-palmitoylationpositiveregulationbyhostofviralprocessproteinpalmitoylationproteintargetingtomembrane
Calnexin
2.0
49
87
✔
CALXCALXP24643P24643clathrin-dependentendocytosisproteinfoldingsynapticvesicleendocytosisubiquitin-dependentERADpathway
Cyclin-A2
2.6
74
85
CCNA2CCNA2P20248P20248animalorganregenerationcellcycleG1/Sphasetransitioncelldivisioncellularresponsetococainecellularresponsetoestradiolstimuluscellularresponsetohypoxiacellularresponsetoinsulin-likegrowthfactorstimuluscellularresponsetoleptinstimuluscellularresponsetoluteinizinghormonestimuluscellularresponsetonitricoxidecellularresponsetoplatelet-derivedgrowthfactorstimuluscochleadevelopmentDNA-templatedtranscriptionG2/MtransitionofmitoticcellcyclemitoticcellcyclephasetransitionpositiveregulationofDNA-templatedtranscriptionpositiveregulationoffibroblastproliferationpost-translationalproteinmodificationRasproteinsignaltransductionregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofDNAreplicationresponsetoglucagon
Protein unc-13 homolog A
3.6
65
93
UN13AUN13AQ4KUS2Q4KUS2amyloid-betametabolicprocesscelldifferentiationdensecoregranulepriminginnervationlong-termsynapticpotentiationneuromuscularjunctiondevelopmentneuronaldensecorevesicleexocytosisneurotransmittersecretionpositiveregulationofdendriteextensionpositiveregulationofglutamatereceptorsignalingpathwaypositiveregulationofneurotransmittersecretionpositiveregulationofsynapticplasticitypresynapticdensecorevesicleexocytosisregulationofamyloidprecursorproteincatabolicprocessregulationofshort-termneuronalsynapticplasticityregulationofsynapticvesicleprimingsynaptictransmissionglutamatergicsynapticvesicledockingsynapticvesicleexocytosissynapticvesiclematurationsynapticvesiclepriming
Lysine-specific demethylase 5A
2.8
66
93
KDM5AKDM5AP29375P29375chromatinremodelingcircadianregulationofgeneexpressionfacultativeheterochromatinformationhistoneH3-K4demethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionregulationofDNA-bindingtranscriptionfactoractivity
39S ribosomal protein S18a, mitochondrial
2.9
66
88
RT18ART18AQ9NVS2Q9NVS2mitochondrialtranslationtranslation
Ubiquitin-40S ribosomal protein S27a
2.6
51
93
G1SK22G1SK22G1SK22G1SK22translation
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
2.6
92
73
MTDCMTDCP13995P13995folicacidmetabolicprocesstetrahydrofolateinterconversiontetrahydrofolatemetabolicprocess
E3 ubiquitin-protein ligase ARIH1
3.5
50
95
ARI1ARI1Q9Y4X5Q9Y4X5positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
GATOR complex protein WDR24
3.0
50
93
WDR24WDR24Q96S15Q96S15autophagycellularresponsetoaminoacidstarvationnegativeregulationofTORC1signalingpositiveregulationofmacroautophagypositiveregulationofproteinkinaseactivitypositiveregulationofTORsignalingpositiveregulationofTORC1signalingregulationofautophagy
Cardiac phospholamban
2.7
60
80
PPLAPPLAP61015P61015acrosomeassemblyadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocesscardiacmuscletissuedevelopmentcellularcalciumionhomeostasismusclecellcellularhomeostasisnegativeregulationofATPase-coupledcalciumtransmembranetransporteractivitynegativeregulationofcalciumionbindingnegativeregulationofcalciumionimportnegativeregulationofcalciumionimportintosarcoplasmicreticulumnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcatalyticactivitynegativeregulationofheartrateNotchsignalingpathwayregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofrelaxationofmuscleregulationofryanodine-sensitivecalcium-releasechannelactivityregulationoftheforceofheartcontractionbycardiacconduction
Fibroblast growth factor receptor 3
3.0
78
79
FGFR3FGFR3P22607P22607bonematurationbonemineralizationbonemorphogenesiscell-cellsignalingchondrocytedifferentiationchondrocyteproliferationendochondralbonegrowthendochondralossificationfibroblastgrowthfactorreceptorapoptoticsignalingpathwayfibroblastgrowthfactorreceptorsignalingpathwayMAPKcascadenegativeregulationofdevelopmentalgrowthpeptidyl-tyrosinephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphospholipaseactivitypositiveregulationoftyrosinephosphorylationofSTATproteinproteinautophosphorylationskeletalsystemdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
Histone-lysine N-methyltransferase 2A
3.3
49
94
KMT2AKMT2AQ03164Q03164anterior/posteriorpatternspecificationapoptoticprocesscircadianregulationofgeneexpressiondefinitivehemopoiesisDNAmethylationembryonichemopoiesisexplorationbehaviorfibroblastproliferationhistoneH3-K4dimethylationhistoneH3-K4methylationhistoneH3-K4monomethylationhistoneH3-K4trimethylationhistonemodificationhomeostasisofnumberofcellswithinatissuemembranedepolarizationnegativeregulationofDNAmethylationnegativeregulationoffibroblastproliferationpeptidyl-lysinemonomethylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransporteractivitypost-embryonicdevelopmentprotein-containingcomplexassemblyregulationofshort-termneuronalsynapticplasticityresponsetopotassiumionspleendevelopmentT-helper2celldifferentiationtranscriptioninitiation-coupledchromatinremodelingvisuallearning
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
2.7
60
79
PDE9APDE9AK7AGW3K7AGW3cGMPcatabolicprocesscGMPmetabolicprocesscGMP-mediatedsignalingpositiveregulationofcardiacmusclehypertrophysignaltransduction
E3 ubiquitin-protein ligase Arkadia
2.7
35
87
RN111RN111Q6ZNA4Q6ZNA4globalgenomenucleotide-excisionrepairpatternspecificationprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinubiquitinationpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocessubiquitin-dependentSMADproteincatabolicprocess
Superoxide dismutase [Cu-Zn]
2.7
80
85
✔
SODCSODCP08228P08228aginganterogradeaxonaltransportapoptoticprocessauditoryreceptorcellstereociliumorganizationcellularironionhomeostasisectopicgermcellprogrammedcelldeathembryoimplantationglutathionemetabolicprocessheartcontractionhydrogenperoxidebiosyntheticprocesslocomotorybehaviormusclecellcellularhomeostasismyeloidcellhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofcholesterolbiosyntheticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofinflammatoryresponsenegativeregulationofneuronapoptoticprocessnegativeregulationofreproductiveprocessneurofilamentcytoskeletonorganizationovarianfollicledevelopmentperipheralnervoussystemmyelinmaintenancepositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofMAPKcascadepositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofphagocytosispositiveregulationofsuperoxideaniongenerationreactiveoxygenspeciesmetabolicprocessregulationofbloodpressureregulationofGTPaseactivityregulationofmitochondrialmembranepotentialregulationofmulticellularorganismgrowthregulationofproteinkinaseactivityrelaxationofvascularassociatedsmoothmuscleremovalofsuperoxideradicalsresponsetoaxoninjuryresponsetocopperionresponsetoethanolresponsetoheatresponsetohydrogenperoxideresponsetonutrientlevelsresponsetoorganicsubstanceresponsetooxidativestressresponsetoreactiveoxygenspeciesresponsetosuperoxideresponsetoxenobioticstimulusretinahomeostasisretrogradeaxonaltransportsensoryperceptionofsoundspermatogenesissuperoxideaniongenerationsuperoxidemetabolicprocesstransmissionofnerveimpulse
ETS translocation variant 1
2.7
61
85
ETV1ETV1P50549P50549axonguidancecelldifferentiationmechanosensorybehaviormuscleorgandevelopmentperipheralnervoussystemneurondevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
DNA (cytosine-5)-methyltransferase 1
3.5
63
91
DNMT1DNMT1P26358P26358cellularresponsetoaminoacidstimuluscellularresponsetobisphenolADNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylation-dependentheterochromatinformationDNA-templatedtranscriptionmaintenanceofDNAmethylationnegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularassociatedsmoothmusclecellapoptoticprocessnegativeregulationofvascularassociatedsmoothmusclecelldifferentiationinvolvedinphenotypicswitchingpositiveregulationofDNAmethylation-dependentheterochromatinformationpositiveregulationofgeneexpressionpositiveregulationofvascularassociatedsmoothmusclecellproliferation
Retinoblastoma-associated protein
2.7
60
81
RBRBP06400P06400aorticvalvemorphogenesiscelldifferentiationcelldivisioncellmorphogenesisinvolvedinneurondifferentiationcellularresponsetoinsulinstimuluscellularresponsetoxenobioticstimuluschondrocytedifferentiationchromatinremodelingchromosomeorganizationdigestivetractdevelopmentenucleateerythrocytedifferentiationepithelialcellproliferationglialcellapoptoticprocessglialcellproliferationhepatocyteapoptoticprocessheterochromatinformationmaintenanceofmitoticsisterchromatidcohesionmyoblastdifferentiationnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcold-inducedthermogenesisnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofinflammatoryresponsenegativeregulationofmyofibroblastdifferentiationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofsmoothenedsignalingpathwaynegativeregulationoftau-proteinkinaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptioninvolvedinG1/Stransitionofmitoticcellcycleneuronapoptoticprocessneuronmaturationneuronprojectiondevelopmentpositiveregulationofcollagenfibrilorganizationpositiveregulationofextracellularmatrixorganizationpositiveregulationofmacrophagedifferentiationpositiveregulationofmitoticmetaphase/anaphasetransitionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinlocalizationtochromosomecentromericregionRasproteinsignaltransductionregulationofcellcycleregulationofcentromerecomplexassemblyregulationofDNA-templatedtranscriptionregulationoflipidkinaseactivityregulationofmitoticcellcyclesisterchromatidbiorientationskeletalmusclecelldifferentiationsmoothenedsignalingpathwayspermatogenesisstriatedmusclecelldifferentiationtissuehomeostasistranscriptionbyRNApolymeraseII
Interleukin-24
2.1
62
85
IL24IL24Q13007Q13007apoptoticprocesscellularresponsetointerleukin-4cellularresponsetolipopolysaccharidenegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationpositiveregulationofcellpopulationproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinserinephosphorylationofSTATproteinwoundhealing
Fanconi anemia group D2 protein
2.7
63
85
FACD2FACD2Q9BXW9Q9BXW9brainmorphogenesiscellularresponsetooxidativestressdouble-strandbreakrepairinvolvedinmeioticrecombinationgametegenerationhomologouschromosomepairingatmeiosisinterstrandcross-linkrepairmitoticintra-SDNAdamagecheckpointsignalingneuronalstemcellpopulationmaintenanceregulationofCD40signalingpathwayregulationofDNA-bindingtranscriptionfactoractivityregulationofinflammatoryresponseregulationofregulatoryTcelldifferentiationresponsetogammaradiation
Histone-lysine N-methyltransferase EZH2
3.6
59
94
EZH2EZH2Q15910Q15910BcelldifferentiationcardiacmusclehypertrophyinresponsetostresscellularresponsetohydrogenperoxidecellularresponsetotrichostatinAcerebellarcortexdevelopmentchromatinorganizationDNAmethylationfacultativeheterochromatinformationG1toG0transitionG1/StransitionofmitoticcellcyclehepatocytehomeostasisheterochromatinformationhippocampusdevelopmenthistoneH3-K27trimethylationkeratinocytedifferentiationliverregenerationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofgeneexpressionepigeneticnegativeregulationofkeratinocytedifferentiationnegativeregulationofretinoicacidreceptorsignalingpathwaynegativeregulationofstemcelldifferentiationnegativeregulationofstriatedmusclecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationofcellcycleG1/SphasetransitionpositiveregulationofcellpopulationproliferationpositiveregulationofdendritedevelopmentpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofGTPaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofproteinserine/threoninekinaseactivityproteinlocalizationtochromatinregulationofcircadianrhythmregulationofDNA-templatedtranscriptionregulationofgliogenesisresponsetoestradiolresponsetotetrachloromethanerhythmicprocessskeletalmusclesatellitecellmaintenanceinvolvedinskeletalmuscleregenerationstemcelldifferentiationsubtelomericheterochromatinformationsynaptictransmissionGABAergic
Regulator of G-protein signaling 3
2.7
77
75
RGS3RGS3P49796P49796Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionregulationofGprotein-coupledreceptorsignalingpathwaysignaltransduction
Antiviral innate immune response receptor RIG-I
3.2
57
87
RIGIRIGIO95786O95786antiviralinnateimmuneresponsecellularresponsetoexogenousdsRNAcytosolicpatternrecognitionreceptorsignalingpathwaydefenseresponsetovirusdetectionofvirusgeneexpressioninnateimmuneresponsepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofgeneexpressionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofcellmigrationregulationoftypeIIIinterferonproductionresponsetoexogenousdsRNAresponsetovirusRIG-Isignalingpathway
40S ribosomal protein S26
2.7
60
84
RS26RS26P61251P61251cytoplasmictranslation
Origin recognition complex subunit 6
2.7
63
83
ORC6ORC6Q9Y5N6Q9Y5N6DNAreplicationinitiationnegativeregulationofcelldivision
NEDD8-activating enzyme E1 catalytic subunit
3.0
73
95
✔
UBA3UBA3Q8TBC4Q8TBC4endomitoticcellcyclepost-translationalproteinmodificationproteinmodificationbysmallproteinconjugationproteinmodificationprocessproteinneddylationproteolysisregulationofcellcycle
Aprataxin and PNK-like factor
2.8
41
90
APLFAPLFQ8IW19Q8IW19cellularresponsetoDNAdamagestimulusDNArepair-dependentchromatinremodelingdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningembryoimplantationpositiveregulationofDNAligationregulationofepithelialtomesenchymaltransitionregulationofisotypeswitchingsinglestrandbreakrepair
Pre-mRNA-processing-splicing factor 8
2.8
76
77
✔
PRP8PRP8Q6P2Q9Q6P2Q9cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactormRNAprocessingmRNAsplicingviaspliceosomeRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomaltri-snRNPcomplexassembly
DNA (cytosine-5)-methyltransferase 3-like
3.8
63
91
DNM3LDNM3LQ9UJW3Q9UJW3C-5methylationofcytosinechorionictrophoblastcelldifferentiationDNAmethylationDNAmethylationinvolvedingametegenerationDNAmethylationoncytosinegenomicimprintinginuteroembryonicdevelopmentmalemeiosisInegativeregulationofDNAmethylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranspositionplacentadevelopmentpositiveregulationofDNAmethylationregulationofgeneexpressionbygenomicimprintingspermatogenesisstemcelldifferentiation
Transcription intermediary factor 1-beta
3.1
67
92
✔
TIF1BTIF1BQ13263Q13263chromatinorganizationconvergentextensioninvolvedinaxiselongationDNAmethylationinvolvedinembryodevelopmentDNArepairembryoimplantationembryonicplacentamorphogenesisepithelialtomesenchymaltransitioninnateimmuneresponsenegativeregulationofDNAdemethylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofDNAmethylation-dependentheterochromatinformationpositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinbindingpositiveregulationofproteinimportintonucleusproteinautophosphorylationproteinsumoylationregulationofgeneticimprintingsuppressionofviralreleasebyhost
DNA dC->dU-editing enzyme APOBEC-3B
3.9
67
80
ABC3BABC3BQ9UH17Q9UH17cytidinetouridineeditingdefenseresponsetovirusDNAcytosinedeaminationDNAdemethylationinnateimmuneresponsenegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftransposition
39S ribosomal protein L32, mitochondrial
2.8
61
93
RM32RM32Q9BYC8Q9BYC8mitochondrialtranslationtranslation
GATOR complex protein WDR59
3.0
71
96
WDR59WDR59Q6PJI9Q6PJI9cellularresponsetoaminoacidstarvationnegativeregulationofTORC1signalingpositiveregulationofTORsignalingpositiveregulationofTORC1signaling
Phospholipid-transporting ATPase IG
2.8
56
81
AT11CAT11CQ8NB49Q8NB49iontransmembranetransportphospholipidtranslocation
Zinc finger and BTB domain-containing protein 7A
3.4
46
95
ZBT7AZBT7AO95365O95365Bcelldifferentiationchromatinorganizationchromatinremodelingdouble-strandbreakrepairviaclassicalnonhomologousendjoiningerythrocytematurationfatcelldifferentiationnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofDNA-templatedtranscriptionnegativeregulationofNotchsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofNF-kappaBtranscriptionfactoractivityproteinlocalizationtonucleusregulationofalternativemRNAsplicingviaspliceosomeregulationofapoptoticprocessregulationofDNA-bindingtranscriptionfactoractivityregulationofglycolyticprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionregulatoryregionDNAbinding
DNA primase small subunit
3.3
67
90
PRI1PRI1P49642P49642DNAreplicationinitiationDNAreplicationsynthesisofRNAprimer
RNA-binding protein NOB1
2.8
72
86
NOB1NOB1Q9ULX3Q9ULX3cleavageinvolvedinrRNAprocessingmaturationofSSU-rRNArRNAprocessingvisualperception
NAD-dependent protein deacetylase sirtuin-2
3.2
43
93
SIR2SIR2Q8IXJ6Q8IXJ6autophagycelldivisioncellularlipidcatabolicprocesscellularresponsetocaloricrestrictioncellularresponsetoepinephrinestimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetohypoxiacellularresponsetomoleculeofbacterialorigincellularresponsetooxidativestresshepatocytegrowthfactorreceptorsignalingpathwayheterochromatinformationhistonedeacetylationhistoneH3deacetylationhistoneH4deacetylationinnateimmuneresponsemeioticcellcyclemitoticnuclearmembranereassemblymyelinationinperipheralnervoussystemnegativeregulationofautophagynegativeregulationofcellpopulationproliferationnegativeregulationofdefenseresponsetobacteriumnegativeregulationofDNA-templatedtranscriptionnegativeregulationoffatcelldifferentiationnegativeregulationofNLRP3inflammasomecomplexassemblynegativeregulationofoligodendrocyteprogenitorproliferationnegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofproteincatabolicprocessnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofstriatedmuscletissuedevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiaNLRP3inflammasomecomplexassemblypeptidyl-lysinedeacetylationphosphatidylinositol3-kinasesignalingpositiveregulationofattachmentofspindlemicrotubulestokinetochorepositiveregulationofcelldivisionpositiveregulationofDNAbindingpositiveregulationofexecutionphaseofapoptosispositiveregulationofmeioticnucleardivisionpositiveregulationofoocytematurationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessinvolvedincellularresponsetohypoxiapositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeacetylationproteinkinaseBsignalingrDNAheterochromatinformationregulationofcellcycleregulationofexitfrommitosisregulationofmyelinationregulationofphosphorylationresponsetoredoxstatesubstantianigradevelopmentsubtelomericheterochromatinformationtubulindeacetylation
E3 ubiquitin-protein ligase RNF216
2.8
44
95
RN216RN216Q9NWF9Q9NWF9apoptoticprocessnegativeregulationoftypeIinterferonproductionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationregulationofdefenseresponsetovirusbyhostregulationofinterferon-betaproduction
40S ribosomal protein S26
3.2
68
81
G1TFE8G1TFE8G1TFE8G1TFE8translation
Torsin-1A
2.8
78
74
TOR1ATOR1AO14656O14656celladhesionchaperonecofactor-dependentproteinrefoldingchaperone-mediatedproteinfoldingER-associatedmisfoldedproteincatabolicprocessintermediatefilamentcytoskeletonorganizationneuronprojectiondevelopmentnuclearenvelopeorganizationnuclearmembraneorganizationorganelleorganizationpositiveregulationofsynapticvesicleendocytosisproteindeneddylationproteinlocalizationtonucleusregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofproteinlocalizationtocellsurfaceresponsetooxidativestresssynapticvesiclemembraneorganizationsynapticvesicletransportwoundhealingspreadingofcells
Tumor protein p73
3.3
57
88
P73P73O15350O15350cellcyclecellularresponsetoDNAdamagestimulusintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorkidneydevelopmentmismatchrepairnegativeregulationofcardiacmusclecellproliferationnegativeregulationofcellpopulationproliferationnegativeregulationofneurondifferentiationpositiveregulationofapoptoticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationoflungciliatedcelldifferentiationpositiveregulationofMAPKcascadepositiveregulationofoligodendrocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIproteintetramerizationregulationofcellcycleregulationofgeneexpressionregulationofmitoticcellcycleregulationoftranscriptionbyRNApolymeraseIIresponsetoorganonitrogencompoundresponsetoxenobioticstimulus
Zinc finger and BTB domain-containing protein 32
2.8
35
95
ZBT32ZBT32Q9JKD9Q9JKD9hemopoiesisnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofcytokineproductionregulationoftranscriptionbyRNApolymeraseIITcellproliferation
Isovaleryl-CoA dehydrogenase, mitochondrial
2.8
59
85
IVDIVDP26440P26440branched-chainaminoacidcatabolicprocessfattyacidbeta-oxidationusingacyl-CoAdehydrogenaseleucinecatabolicprocess
Baculoviral IAP repeat-containing protein 3
3.6
57
88
BIRC3BIRC3Q13489Q13489cellsurfacereceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalingnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessNIK/NF-kappaBsignalingpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcysteine-typeendopeptidaseactivityregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnecroptoticprocessregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayregulationofRIG-Isignalingpathwayregulationoftoll-likereceptorsignalingpathwayspermatogenesistumornecrosisfactor-mediatedsignalingpathway
TNF receptor-associated factor 6
3.5
nan
93
TRAF6TRAF6Q9Y4K3Q9Y4K3activationofNF-kappaB-inducingkinaseactivityactivationofproteinkinaseactivityantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIboneresorptioncellularresponsetocytokinestimuluscellularresponsetoDNAdamagestimuluscellularresponsetolipopolysaccharidecytosolicpatternrecognitionreceptorsignalingpathwayFc-epsilonreceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinterleukin-1-mediatedsignalingpathwayinterleukin-17-mediatedsignalingpathwaylipopolysaccharide-mediatedsignalingpathwayMyD88-dependenttoll-likereceptorsignalingpathwaymyeloiddendriticcelldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIneuraltubeclosureodontogenesisofdentin-containingtoothossificationosteoclastdifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofosteoclastdifferentiationpositiveregulationofproteinubiquitinationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinautoubiquitinationproteinK63-linkedubiquitinationproteinpolyubiquitinationregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingregulationofimmunoglobulinproductionresponsetointerleukin-1stimulatoryC-typelectinreceptorsignalingpathwayTcellreceptorsignalingpathwayT-helper1typeimmuneresponsetumornecrosisfactor-mediatedsignalingpathway
Aldehyde dehydrogenase, mitochondrial
2.0
nan
91
✔
TOM20ALDH2Q62760P11884proteinimportintomitochondrialmatrixproteintargetingtomitochondrion"responseto335-triiodo-L-thyronine"responsetomuscleactivitytRNAimportintomitochondrionacetaldehydemetabolicprocessaldehydecatabolicprocessapoptoticmitochondrialchangesbehavioralresponsetoethanolcellulardetoxificationofaldehydecellularresponsetofattyacidcellularresponsetohormonestimuluscellularresponsetoresveratrolethanolcatabolicprocessethanolmetabolicprocessintrinsicapoptoticsignalingpathwayinresponsetooxidativestressliverdevelopmentnegativeregulationofapoptoticprocessregulationofdopaminebiosyntheticprocessregulationofinflammatoryresponseregulationofreactiveoxygenspeciesmetabolicprocessregulationofresponsetooxidativestressregulationofserotoninbiosyntheticprocessresponsetoestradiolresponsetoethanolresponsetoheatresponsetohyperoxiaresponsetoischemiaresponsetolipopolysaccharideresponsetonicotineresponsetoorganiccycliccompoundresponsetoprogesteroneresponsetotestosterone
DNA dC->dU-editing enzyme APOBEC-3G
2.9
66
93
ABC3GABC3GQ9HC16Q9HC16baseconversionorsubstitutioneditingcytidinedeaminationcytidinetouridineeditingdefenseresponsetovirusDNAcytosinedeaminationDNAdemethylationinnateimmuneresponsenegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftranspositionnegativeregulationofviralgenomereplicationnegativeregulationofviralprocesspositiveregulationofdefenseresponsetovirusbyhost
Non-receptor tyrosine-protein kinase TYK2
2.9
66
83
✔
TYK2TYK2P29597P29597celldifferentiationcellularresponsetoviruscytokine-mediatedsignalingpathwaygrowthhormonereceptorsignalingpathwayviaJAK-STATimmuneresponseintracellularsignaltransductionpositiveregulationofinterleukin-17productionpositiveregulationofnaturalkillercellproliferationpositiveregulationofNKTcellproliferationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellproliferationpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftypeIIinterferonproductionproteinphosphorylationreceptorsignalingpathwayviaJAK-STATtypeIinterferon-mediatedsignalingpathwaytypeIIinterferon-mediatedsignalingpathwaytypeIIIinterferon-mediatedsignalingpathway
E3 ubiquitin-protein ligase RNF128
2.9
48
85
RN128RN128Q8TEB7Q8TEB7negativeregulationofcytokineproductionpositiveregulationofproteincatabolicprocessinthevacuoleproteinlocalizationtolysosomeregulationofproteinstabilityubiquitin-dependentproteincatabolicprocess
PHD finger protein 23
3.7
44
91
PHF23PHF23Q9BUL5Q9BUL5autophagynegativeregulationofautophagosomeassemblynegativeregulationofautophagosomematurationpositiveregulationofproteinubiquitination
Ubiquitin carboxyl-terminal hydrolase 12
3.5
50
89
UBP12UBP12O75317O75317proteindeubiquitinationubiquitin-dependentproteincatabolicprocess
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
2.9
96
76
NDUV2NDUV2Q9D6J6Q9D6J6aerobicrespirationcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesis
Methionine-R-sulfoxide reductase B1
3.7
58
84
MSRB1MSRB1Q9NZV6Q9NZV6actinfilamentpolymerizationinnateimmuneresponseproteinrepair
Myeloid differentiation primary response protein MyD88
3.8
75
74
MYD88MYD88Q99836Q99836"3-UTR-mediatedmRNAstabilization"apoptoticprocesscellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetooxidisedlow-densitylipoproteinparticlestimulusdefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoandefenseresponsetovirusestablishmentofendothelialintestinalbarriergeneexpressionhistonemethylationI-kappaBkinase/NF-kappaBsignalingimmunoglobulinmediatedimmuneresponseinducedsystemicresistanceinnateimmuneresponseinterleukin-1-mediatedsignalingpathwayJNKcascadeleukocyteactivationinvolvedininflammatoryresponselipopolysaccharide-mediatedsignalingpathwayMyD88-dependenttoll-likereceptorsignalingpathwayneutrophilactivationinvolvedinimmuneresponseneutrophil-mediatedkillingofbacteriumphagocytosispositiveregulationofchemokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-17productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationoflymphocyteproliferationpositiveregulationofmacrophagecytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferonproductionregulationofchemokine(C-X-Cmotif)ligand1productionregulationofchemokine(C-X-Cmotif)ligand2productionregulationofinflammatoryresponseregulationofneutrophilmigrationresponsetoamineresponsetoaminoacidresponsetoethanolresponsetointerleukin-1responsetomoleculeoffungaloriginresponsetoorganiccycliccompoundresponsetopeptidoglycansignaltransductionskindevelopmentTollsignalingpathwaytoll-likereceptor8signalingpathwaytypeIinterferon-mediatedsignalingpathway
Actin-related protein 3
2.9
67
84
ARP3ARP3P61157P61157Arp2/3complex-mediatedactinnucleationciliumassemblypositiveregulationoflamellipodiumassemblypositiveregulationoftranscriptionbyRNApolymeraseII
Nuclear receptor subfamily 1 group D member 1
2.9
42
95
NR1D1NR1D1P20393P20393celldifferentiationcellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorcholesterolhomeostasiscircadianregulationofgeneexpressioncircadiantemperaturehomeostasisglycogenbiosyntheticprocesshormone-mediatedsignalingpathwaynegativeregulationofastrocyteactivationnegativeregulationofcold-inducedthermogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofmicroglialcellactivationnegativeregulationofneuroinflammatoryresponsenegativeregulationoftoll-likereceptor4signalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofbileacidbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIproteasomalproteincatabolicprocessproteindestabilizationregulationofcircadianrhythmregulationofcircadiansleep/wakecycleregulationoffatcelldifferentiationregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusregulationoflipidmetabolicprocessregulationoftypeBpancreaticcellproliferationresponsetoleptin
Transcription factor GATA-4
2.9
55
89
GATA4GATA4P43694P43694aorticvalvemorphogenesisatrialseptummorphogenesisatrialseptumprimummorphogenesisatrialseptumsecundummorphogenesisatrioventricularcanaldevelopmentatrioventricularnodedevelopmentatrioventricularvalveformationcardiacmuscletissueregenerationcardiacrightventriclemorphogenesiscardiacventriclemorphogenesiscellfatecommitmentcellgrowthinvolvedincardiacmusclecelldevelopmentcell-cellsignalingcellularresponsetoglucosestimulusembryonicforegutmorphogenesisembryonichearttubeanterior/posteriorpatternspecificationendocardialcushiondevelopmentendodermdevelopmentheartloopingintestinalepithelialcelldifferentiationmalegonaddevelopmentnegativeregulationofapoptoticsignalingpathwaynegativeregulationofautophagynegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofoxidativestress-inducedcelldeathnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofangiogenesispositiveregulationofBMPsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialgrowthfactorproductionregulationofcardiacmusclecellcontractionregulationofDNA-templatedtranscriptionregulationofproteinkinaseBsignalingresponsetomechanicalstimulusresponsetovitaminAresponsetoxenobioticstimulustransdifferentiationventricularseptumdevelopmentwoundhealing
RecQ-like DNA helicase BLM
4.4
69
86
BLMBLMP54132P54132cellularresponsetocamptothecincellularresponsetoDNAdamagestimuluscellularresponsetohydroxyureacellularresponsetoionizingradiationDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviahomologousrecombinationG-quadruplexDNAunwindingmitoticG2DNAdamagecheckpointsignalingnegativeregulationofcelldivisionnegativeregulationofDNArecombinationpositiveregulationofDNA-templatedtranscriptionproteincomplexoligomerizationproteinhomooligomerizationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofDNA-templatedDNAreplicationreplicationforkprocessingreplicationforkprotectionresolutionofrecombinationintermediatesresponsetoX-rayt-circleformationtelomeremaintenancetelomeremaintenanceviasemi-conservativereplicationtelomericD-loopdisassembly
Lysine-specific demethylase 4D
2.9
48
97
KDM4DKDM4DQ6B0I6Q6B0I6cellularresponsetoionizingradiationchromatinremodelingdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofchromatinbindingpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningregulationofproteinphosphorylation
DNA-directed RNA polymerase III subunit RPC2
3.2
61
79
RPC2RPC2Q9NW08Q9NW08defenseresponsetovirusDNA-templatedtranscriptioninnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproduction
tRNA-specific adenosine deaminase 2
4.0
70
78
ADAT2ADAT2Q7Z6V5Q7Z6V5tRNAwobbleadenosinetoinosineediting
ATP-dependent DNA helicase Q5
3.0
57
83
✔
RECQ5RECQ5O94762O94762celldivisioncellularresponsetocamptothecincellularresponsetoketonecellularresponsetoxenobioticstimuluschromosomeseparationDNAduplexunwindingDNAmetabolicprocessDNArecombinationDNArepairDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviahomologousrecombinationmitoticcellcyclenegativeregulationofdouble-strandbreakrepairviahomologousrecombinationnegativeregulationoftranscriptionelongationbyRNApolymeraseIIreplication-borndouble-strandbreakrepairviasisterchromatidexchange
N-lysine methyltransferase SMYD2
3.3
64
86
✔
SMYD2SMYD2Q9NRG4Q9NRG4chromatinorganizationheartdevelopmenthistonelysinemethylationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-lysinedimethylationpeptidyl-lysinemonomethylationregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationofsignaltransductionbyp53classmediator
40S ribosomal protein S29
3.2
53
93
G1U7M4G1U7M4G1U7M4G1U7M4translation
E3 ubiquitin-protein ligase CBL
4.0
61
86
CBLCBLP22681P22681cellsurfacereceptorsignalingpathwaycellularresponsetoDNAdamagestimuluscellularresponsetonervegrowthfactorstimuluscellularresponsetooxygen-glucosedeprivationcellularresponsetoplatelet-derivedgrowthfactorstimuluscytokine-mediatedsignalingpathwayentryofbacteriumintohostcellepidermalgrowthfactorreceptorsignalingpathwaymalegonaddevelopmentmastcelldegranulationnegativeregulationofapoptoticprocessnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofepidermalgrowthfactor-activatedreceptoractivitynegativeregulationofneurondeathneurondeathpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofreceptor-mediatedendocytosisproteinautoubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofplatelet-derivedgrowthfactorreceptor-alphasignalingpathwayregulationofRapproteinsignaltransductionresponsetoactivityresponsetoantibioticresponsetoethanolresponsetogammaradiationresponsetostarvationresponsetotestosteronesignaltransductionubiquitin-dependentproteincatabolicprocess
DNA-directed RNA polymerase II subunit RPB1
4.1
50
80
RPB1RPB1P24928P24928DNA-templatedtranscriptionterminationpositiveregulationofRNAsplicingregulationofDNA-templatedtranscriptiontranscriptionbyRNApolymeraseII
Ubiquitin-conjugating enzyme E2 D3
3.7
75
81
UB2D3UB2D3P61077P61077apoptoticprocessDNArepairnegativeregulationofBMPsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofproteintargetingtomitochondrionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinK11-linkedubiquitinationproteinK48-linkedubiquitinationproteinmodificationprocessproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitination
ATP-dependent DNA helicase Q1
3.0
58
86
RECQ1RECQ1P46063P46063DNAduplexunwindingDNArecombinationDNArepairDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviahomologousrecombination
Ubiquitin-protein ligase E3A
3.0
46
90
Q9H2G0Q9H2G0Q9H2G0Q9H2G0proteinK48-linkedubiquitinationubiquitin-dependentproteincatabolicprocess
Interferon-induced helicase C domain-containing protein 1
3.8
51
85
IFIH1IFIH1Q9BYX4Q9BYX4antiviralinnateimmuneresponsecellularresponsetoexogenousdsRNAcellularresponsetoviruscytosolicpatternrecognitionreceptorsignalingpathwaydefenseresponsetovirusdetectionofvirusinnateimmuneresponseMDA-5signalingpathwaynegativeregulationofviralgenomereplicationpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofresponsetocytokinestimuluspositiveregulationoftumornecrosisfactorproductionproteinsumoylationregulationoftypeIIIinterferonproductionresponsetovirus
Adrenodoxin, mitochondrial
3.3
72
84
ADXADXP10109P10109cellularresponsetocAMPcellularresponsetoforskolincholesterolmetabolicprocesselectrontransportchainhormonebiosyntheticprocessP450-containingelectrontransportchainpositiveregulationofoxidoreductaseactivitysteroidbiosyntheticprocess
Estrogen receptor
3.2
79
86
ESR1ESR1P03372P03372androgenmetabolicprocessantralovarianfolliclegrowthcellularresponsetoestradiolstimuluscellularresponsetoestrogenstimuluschromatinremodelingepithelialcelldevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationfibroblastproliferationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymalegonaddevelopmentmammaryglandalveolusdevelopmentmammaryglandbranchinginvolvedinpregnancynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmiRNAtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationoffibroblastproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisprostateepithelialcordelongationproteinlocalizationtochromatinregulationofbranchinginvolvedinprostateglandmorphogenesisregulationofDNA-templatedtranscriptionregulationofepithelialcellapoptoticprocessregulationofinflammatoryresponseregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetoestradiolresponsetoestrogensignaltransductionstemcelldifferentiationtranscriptionbyRNApolymeraseIIuterusdevelopmentvaginadevelopment
DNA polymerase alpha catalytic subunit
3.0
62
96
DPOLADPOLAP09884P09884DNArepairDNAreplicationDNAreplicationinitiationDNAreplicationsynthesisofRNAprimerDNAstrandelongationinvolvedinDNAreplicationDNAsynthesisinvolvedinDNArepairdouble-strandbreakrepairvianonhomologousendjoininglaggingstrandelongationleadingstrandelongationmitoticDNAreplicationinitiationregulationoftypeIinterferonproduction
Tumor protein 63
3.6
73
88
P63P63Q9H3D4Q9H3D4apoptoticprocesscellularresponsetoDNAdamagestimuluscellularsenescencechromatinremodelingcloacalseptationcranialskeletalsystemdevelopmentectodermandmesoderminteractionembryonicforelimbmorphogenesisembryonichindlimbmorphogenesisepidermalcelldivisionepithelialcelldevelopmentestablishmentofplanarpolarityestablishmentofskinbarrierfemalegenitaliamorphogenesishairfolliclemorphogenesisintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorkeratinocytedifferentiationkeratinocyteproliferationmulticellularorganismagingnegativeregulationofcellularsenescencenegativeregulationofDNA-templatedtranscriptionnegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationofkeratinocytedifferentiationnegativeregulationofmesodermdevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIIneuronapoptoticprocessNotchsignalingpathwayodontogenesisofdentin-containingtoothpolarizedepithelialcelldifferentiationpositiveregulationofapoptoticsignalingpathwaypositiveregulationofcellcycleG1/SphasetransitionpositiveregulationofDNA-templatedtranscriptionpositiveregulationoffibroblastapoptoticprocesspositiveregulationofkeratinocyteproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofosteoblastdifferentiationpositiveregulationofsomaticstemcellpopulationmaintenancepositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpost-analtailmorphogenesisprostaticbudformationproteintetramerizationproximal/distalpatternformationregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessregulationofepidermalcelldivisionregulationoftranscriptionbyRNApolymeraseIIskeletalsystemdevelopmentskinmorphogenesisspermatogenesissquamousbasalepithelialstemcelldifferentiationinvolvedinprostateglandacinusdevelopmentstemcellproliferationsympatheticnervoussystemdevelopmenttranscriptionbyRNApolymeraseII
General transcription factor IIE subunit 1
3.0
47
91
T2EAT2EAP29083P29083transcriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromotertranscriptionopencomplexformationatRNApolymeraseIIpromoter
Lysine-specific demethylase 4A
3.0
49
89
KDM4AKDM4AO75164O75164cardiacmusclehypertrophyinresponsetostresschromatinremodelinghistonelysinedemethylationnegativeregulationofastrocytedifferentiationnegativeregulationofautophagynegativeregulationofcelldeathnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionpositiveregulationofgeneexpressionpositiveregulationofneurondifferentiationresponsetonutrientlevels
Lysine-specific demethylase PHF2
3.6
54
87
PHF2PHF2O75151O75151liverdevelopmentnegativeregulationofrDNAheterochromatinformationproteindemethylationregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiation-coupledchromatinremodeling
D-3-phosphoglycerate dehydrogenase
3.0
96
71
SERASERAO43175O43175braindevelopmentG1toG0transitiongamma-aminobutyricacidmetabolicprocessglialcelldevelopmentglutaminemetabolicprocessglycinemetabolicprocessL-serinebiosyntheticprocessneuraltubedevelopmentneuronprojectiondevelopmentregulationofgeneexpressionspinalcorddevelopmenttaurinemetabolicprocessthreoninemetabolicprocess
Androgen receptor
3.3
65
89
ANDRANDRP15207P15207activationofprostateinductionbyandrogenreceptorsignalingpathwayandrogenreceptorsignalingpathwayanimalorganformationcellularresponsetoestrogenstimuluscellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetosteroidhormonestimuluscellularresponsetotestosteronestimuluscopulationDNA-templatedtranscriptionepithelialcelldifferentiationinvolvedinprostateglanddevelopmentepithelialcellmorphogenesisepithelialcellproliferationfertilizationinuteroembryonicdevelopmentinsulin-likegrowthfactorreceptorsignalingpathwayintracellularestrogenreceptorsignalingpathwayintracellularreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaylateralsproutinginvolvedinmammaryglandductmorphogenesisLeydigcelldifferentiationmalecourtshipbehaviormalegenitaliamorphogenesismalegonaddevelopmentmalesexdifferentiationmalesomaticsexdeterminationmammaryglandalveolusdevelopmentMAPKcascademorphogenesisofanepithelialfoldmulticellularorganismgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofintegrinbiosyntheticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentpositiveregulationofgeneexpressionpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofintegrinbiosyntheticprocesspositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmiRNAtranscriptionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpenileerectionpositiveregulationofphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIprostateglandepitheliummorphogenesisprostateglandgrowthregulationofdevelopmentalgrowthregulationofDNA-templatedtranscriptionregulationofgeneexpressionregulationofprostaticbudformationregulationofproteinlocalizationtoplasmamembraneregulationofsystemicarterialbloodpressureregulationoftranscriptionbyRNApolymeraseIIreproductivebehaviorreproductivestructuredevelopmentreproductivesystemdevelopmentresponsetoestradiolresponsetoinsulinresponsetotestosteroneseminiferoustubuledevelopmentsinglefertilizationskeletalmusclehypertrophyspermatogenesistertiarybranchinginvolvedinmammaryglandductmorphogenesistranscriptionbyRNApolymeraseII
Beta-defensin 106
3.1
50
86
D106AD106AQ8N104Q8N104antifungalinnateimmuneresponsedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
DNA-directed RNA polymerase II subunit RPB3
3.0
40
92
I3LCH3I3LCH3I3LCH3I3LCH3transcriptionbyRNApolymeraseII
Trans-acting T-cell-specific transcription factor GATA-3
3.5
65
95
GATA3GATA3P23772P23772anatomicalstructureformationinvolvedinmorphogenesisaorticvalvemorphogenesisaxonguidancecanonicalWntsignalingpathwayinvolvedinmetanephrickidneydevelopmentcardiacrightventriclemorphogenesiscartilagedevelopmentcellfatecommitmentcellfatedeterminationcellmaturationcellmorphogenesiscellpopulationproliferationcellularresponsetoBMPstimuluscellularresponsetocytokinestimuluscellularresponsetointerferon-alphacellularresponsetointerleukin-4cellularresponsetotumornecrosisfactorchromatinremodelingcochleadevelopmentdevelopmentalgrowtheardevelopmentembryonichemopoiesisembryonicorgandevelopmenterythrocytedifferentiationgeneexpressionhomeostasisofnumberofcellshumoralimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentinflammatoryresponseinnateimmuneresponseinnerearmorphogenesiskidneydevelopmentlensdevelopmentincamera-typeeyelymphocytemigrationmacrophagedifferentiationmalegonaddevelopmentmastcelldifferentiationmesenchymaltoepithelialtransitionmesonephrosdevelopmentnaturalkillercellactivationnegativeregulationofcellcyclenegativeregulationofcellmotilitynegativeregulationofcellpopulationproliferationnegativeregulationofcellproliferationinvolvedinmesonephrosdevelopmentnegativeregulationofDNAdemethylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationoffatcelldifferentiationnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwayinvolvedinuretericbudformationnegativeregulationofgeneexpressionnegativeregulationofglialcell-derivedneurotrophicfactorreceptorsignalingpathwayinvolvedinuretericbudformationnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-2productionnegativeregulationofmammaryglandepithelialcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftypeIIinterferonproductionnephricductformationnephricductmorphogenesisnervoussystemdevelopmentneurondifferentiationneuronmigrationnorepinephrinebiosyntheticprocessoticvesicledevelopmentparathyroidglanddevelopmentparathyroidhormonesecretionpharyngealsystemdevelopmentphosphatidylinositol3-kinasesignalingpositiveregulationofcelldifferentiationpositiveregulationofcytokineproductionpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofhistoneH3-K14acetylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-4productionpositiveregulationofinterleukin-5productionpositiveregulationofmiRNAtranscriptionpositiveregulationofproteinkinaseBsignalingpositiveregulationofsignaltransductionpositiveregulationofTcelldifferentiationpositiveregulationofT-helper2cellcytokineproductionpositiveregulationofthyroidhormonegenerationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofuretericbudformationpost-embryonicdevelopmentpro-TcelldifferentiationregulationofcellularresponsetoX-rayregulationofcytokineproductionregulationofepithelialcelldifferentiationregulationofestablishmentofcellpolarityregulationofhistoneH3-K27methylationregulationofhistoneH3-K4methylationregulationofnephrontubuleepithelialcelldifferentiationregulationofneuronapoptoticprocessregulationofneuronprojectiondevelopmentregulationofT-helpercelldifferentiationregulationoftranscriptionbyRNApolymeraseIIresponsetoestrogenresponsetoethanolresponsetogammaradiationresponsetovirusresponsetoxenobioticstimulussignaltransductionsympatheticnervoussystemdevelopmentTcelldifferentiationTcelldifferentiationinthymusTcellreceptorsignalingpathwayT-helper2celldifferentiationthymicTcellselectionthymusdevelopmentTORsignalingtranscriptionbyRNApolymeraseIItypeIVhypersensitivityuretermaturationuretermorphogenesisuretericbudformationuterusdevelopmentventricularseptumdevelopment
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
3.4
52
80
F1SLR1F1SLR1F1SLR1F1SLR1mitochondrialelectrontransportNADHtoubiquinone
Histone lysine demethylase PHF8
3.0
43
87
PHF8PHF8Q9UPP1Q9UPP1braindevelopmentchromatinorganizationG1/StransitionofmitoticcellcyclenegativeregulationofrDNAheterochromatinformationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIproteindemethylationregulationoftranscriptionbyRNApolymeraseII
Glutamate receptor ionotropic, NMDA 1
2.0
nan
88
NMDZ1NMDZ1Q05586Q05586braindevelopmentcalciumionhomeostasiscalciumiontransmembraneimportintocytosolcationtransmembranetransportcationtransportchemicalsynaptictransmissionexcitatorychemicalsynaptictransmissionexcitatorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaypositiveregulationofcalciumiontransportintocytosolpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftranscriptionbyRNApolymeraseIIpropylenemetabolicprocessproteinheterotetramerizationregulationofcationtransmembranetransportregulationofmembranepotentialregulationofneuronalsynapticplasticityregulationofsynapticplasticityresponsetoethanolresponsetoglycinevisuallearning
Myeloperoxidase
2.0
60
85
PERMPERMP05164P05164agingdefenseresponsedefenseresponsetobacteriumdefenseresponsetofungushydrogenperoxidecatabolicprocesshypochlorousacidbiosyntheticprocesslow-densitylipoproteinparticleremodelingnegativeregulationofapoptoticprocessremovalofsuperoxideradicalsrespiratoryburstinvolvedindefenseresponseresponsetofoodresponsetogoldnanoparticleresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetooxidativestressresponsetoyeast
E3 ubiquitin-protein ligase AMFR
3.6
33
89
AMFRAMFRQ9UKV5Q9UKV5agingendoplasmicreticulummannosetrimmingendoplasmicreticulumunfoldedproteinresponselearningormemorynegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofproteinbindingproteinautoubiquitinationproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofSREBPsignalingpathwaysignaltransductionubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocessWntsignalingpathway
Inositol 1,4,5-trisphosphate receptor type 1
4.5
54
77
ITPR1ITPR1P29994P29994calciumiontransportcalcium-mediatedsignalingcellmorphogenesiscellularresponsetocAMPcellularresponsetohypoxiadendritedevelopmentendoplasmicreticulumcalciumionhomeostasisepithelialfluidtransportinositolphosphate-mediatedsignalingintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressionchannelmodulatingGprotein-coupledreceptorsignalingpathwayligand-gatedionchannelsignalingpathwayliverregenerationnegativeregulationofcalcium-mediatedsignalingnegativeregulationofneurondeathphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofcalciumiontransportpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofhepatocyteproliferationpositiveregulationofinsulinsecretionpositiveregulationofneuronprojectiondevelopmentpost-embryonicdevelopmentregulationofpostsynapticcytosoliccalciumionconcentrationreleaseofsequesteredcalciumionintocytosolresponsetohypoxiavoluntarymusculoskeletalmovement
Cytosolic phospholipase A2 delta
3.0
63
81
PA24DPA24DQ86XP0Q86XP0fattyacidmetabolicprocessglycerophospholipidcatabolicprocessphosphatidylglycerolacyl-chainremodelingphosphatidylinositolacyl-chainremodeling
Bifunctional glutamate/proline--tRNA ligase
3.2
61
89
SYEPSYEPP07814P07814cellularresponsetoinsulinstimuluscellularresponsetotypeIIinterferonglutamyl-tRNAaminoacylationnegativeregulationoftranslationprolyl-tRNAaminoacylationprotein-containingcomplexassemblyregulationoflong-chainfattyacidimportintocelltRNAaminoacylationforproteintranslation
Interleukin-23 subunit alpha
3.0
48
82
IL23AIL12BQ9NPF7P29460defenseresponsetoGram-negativebacteriumdefenseresponsetovirusimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofinterleukin-10productionpositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationofmemoryTcelldifferentiationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellproliferationpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17celllineagecommitmentpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftissueremodelingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationoftyrosinephosphorylationofSTATproteinTcellproliferationtissueremodelingcellmigrationcellularresponsetolipopolysaccharidecellularresponsetotypeIIinterferoncytokine-mediatedsignalingpathwaydefenseresponsetoprotozoannaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcelladhesionpositiveregulationoflymphocyteproliferationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofsmoothmusclecellapoptoticprocessregulationofcytokineproductionresponsetoUV-BsensoryperceptionofpainsexualreproductionT-helper1typeimmuneresponseT-helpercelldifferentiation
Zinc fingers and homeoboxes protein 1
3.0
62
76
ZHX1ZHX1Q9UKY1Q9UKY1celldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
3.6
51
85
ADH1BADH1BP00325P00325ethanoloxidationretinoicacidmetabolicprocessretinoidmetabolicprocessretinolmetabolicprocess
Histone-lysine N-methyltransferase SMYD3
3.3
50
92
SMYD3SMYD3Q9H7B4Q9H7B4cellularresponsetodexamethasonestimulusestablishmentofproteinlocalizationhistonelysinemethylationmyotubecelldevelopmentnegativeregulationofproteinkinaseactivitynucleosomeassemblypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseII
Mediator of RNA polymerase II transcription subunit 24
3.8
54
87
MED24MED24O75448O75448positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassembly
Dihydrolipoyl dehydrogenase, mitochondrial
3.0
82
73
✔
DLDHDLDHP09622P09622acetyl-CoAbiosyntheticprocessfrompyruvatebranched-chainaminoacidcatabolicprocessgastrulationhistonesuccinylationmitochondrialelectrontransportNADHtoubiquinoneproteolysisregulationofmembranepotentialspermcapacitation
Anaphase-promoting complex subunit 2
3.4
57
87
ANC2ANC2Q9UJX6Q9UJX6anaphase-promotingcomplex-dependentcatabolicprocesscelldifferentiationcelldivisionmetaphase/anaphasetransitionofmitoticcellcyclenegativeregulationofgeneexpressionnervoussystemdevelopmentpositiveregulationofaxonextensionpositiveregulationofdendritemorphogenesispositiveregulationofsynapsematurationpositiveregulationofsynapticplasticityproteinK11-linkedubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycle
Adenylate cyclase type 10
3.0
75
79
ADCYAADCYAQ96PN6Q96PN6cAMPbiosyntheticprocesscellularresponsetoinorganicsubstanceepithelialciliummovementinvolvedinextracellularfluidmovementintracellularsignaltransductionpositiveregulationofapoptoticprocessspermatogenesis
Retinoic acid receptor beta
3.3
50
87
RARBRARBP10826P10826apoptoticprocesscelldifferentiationembryonicdigestivetractdevelopmentembryoniceyemorphogenesisembryonichindlimbmorphogenesisglandularepithelialcelldevelopmentgrowthplatecartilagedevelopmenthormone-mediatedsignalingpathwaymulticellularorganismgrowthnegativeregulationofchondrocytedifferentiationnegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIneurogenesispositiveregulationofapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIretinoicacidreceptorsignalingpathwaysignaltransductionstemcellproliferationstriatumdevelopmenturetericbuddevelopmentventricularcardiacmusclecelldifferentiation
Ganglioside-induced differentiation-associated protein 1
3.0
70
77
GDAP1GDAP1Q8TB36Q8TB36cellularresponsetovitaminDmitochondrialfissionmitochondrialfusionproteintargetingtomitochondrionresponsetoretinoicacid
Zinc finger protein 410
3.1
38
93
ZN410ZN410Q86VK4Q86VK4negativeregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Hexokinase-1
3.1
77
77
HXK1HXK1P19367P19367canonicalglycolysiscarbohydratephosphorylationcellularglucosehomeostasisestablishmentofproteinlocalizationtomitochondrionfructose6-phosphatemetabolicprocessglucose6-phosphatemetabolicprocessglucosemetabolicprocessglycolyticprocessinflammatoryresponseinnateimmuneresponsemaintenanceofproteinlocationinmitochondrionmannosemetabolicprocesspositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofinterleukin-1betaproduction
RNA polymerase II, I and III subunit K
3.1
66
88
I3LN51I3LN51I3LN51I3LN51transcriptionbyRNApolymeraseII
Antigen-presenting glycoprotein CD1d
3.1
70
78
CD1DCD1DP15813P15813antigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbdetectionofbacteriumheterotypiccell-celladhesioninnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationTcellselection
Galactokinase
3.1
74
73
GALK1GALK1P51570P51570galactitolmetabolicprocessgalactosecatabolicprocessgalactosecatabolicprocessviaUDP-galactosegalactosemetabolicprocessglycolyticprocessfromgalactose
Histone deacetylase 4
3.1
44
92
HDAC4HDAC4P56524P56524BcellactivationBcelldifferentiationcardiacmusclehypertrophyinresponsetostresschromatinremodelingepigeneticregulationofgeneexpressionhistonedeacetylationhistoneH3deacetylationhistoneH4deacetylationinflammatoryresponsenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofglycolyticprocessnegativeregulationofmyotubedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpeptidyl-lysinedeacetylationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinsumoylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteindeacetylationproteinsumoylationregulationofproteinbindingresponsetodenervationinvolvedinregulationofmuscleadaptationresponsetointerleukin-1
Fatty acid synthase
3.1
72
82
A5YV76A5YV76A5YV76A5YV76fattyacidbiosyntheticprocess
PHD finger protein 20
3.7
52
88
PHF20PHF20Q9BVI0Q9BVI0chromatinorganizationhistoneacetylationhistoneH4-K16acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofhistoneH3-K4methylationregulationofdosagecompensationbyinactivationofXchromosomeregulationoftranscriptionbyRNApolymeraseII
Peroxisome proliferator-activated receptor gamma
3.8
42
88
PPARGPPARGP37231P37231activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBMPsignalingpathwaycelldifferentiationcellfatecommitmentcellmaturationcellularresponsetohypoxiacellularresponsetoinsulinstimuluscellularresponsetolow-densitylipoproteinparticlestimulusepithelialcelldifferentiationfattyacidmetabolicprocessglucosehomeostasishormone-mediatedsignalingpathwayinnateimmuneresponselipidhomeostasislipidmetabolicprocesslipoproteintransportlong-chainfattyacidtransportmacrophagederivedfoamcelldifferentiationmonocytedifferentiationmRNAtranscriptionbyRNApolymeraseIInegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofBMPsignalingpathwaynegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofcholesterolstoragenegativeregulationofconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationofinflammatoryresponsenegativeregulationoflipidstoragenegativeregulationofmacrophagederivedfoamcelldifferentiationnegativeregulationofMAPkinaseactivitynegativeregulationofmiRNAtranscriptionnegativeregulationofmiRNA-mediatedgenesilencingnegativeregulationofmitochondrialfissionnegativeregulationofosteoblastdifferentiationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofreceptorsignalingpathwayviaSTATnegativeregulationofsequesteringoftriglyceridenegativeregulationofsignalingreceptoractivitynegativeregulationofSMADproteinsignaltransductionnegativeregulationofsmoothmusclecellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationoftypeIIinterferon-mediatedsignalingpathwaynegativeregulationofvascularassociatedsmoothmusclecellproliferationnegativeregulationofvascularendothelialcellproliferationperoxisomeproliferatoractivatedreceptorsignalingpathwayplacentadevelopmentpositiveregulationofadiponectinsecretionpositiveregulationofadiposetissuedevelopmentpositiveregulationofcholesteroleffluxpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationoffatcelldifferentiationpositiveregulationoffattyacidmetabolicprocesspositiveregulationofgeneexpressionpositiveregulationoflow-densitylipoproteinreceptoractivitypositiveregulationofmiRNAtranscriptionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularassociatedsmoothmusclecellapoptoticprocessregulationofbloodpressureregulationofcellularresponsetoinsulinstimulusregulationofcholesteroltransporteractivityregulationofcircadianrhythmregulationoflipidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIresponsetolipidresponsetonutrientretinoicacidreceptorsignalingpathwayrhythmicprocesssignaltransductionwhitefatcelldifferentiation
Phenylethanolamine N-methyltransferase
3.1
65
74
PNMTPNMTP11086P11086catecholaminebiosyntheticprocessepinephrinebiosyntheticprocessmethylation
Talin-1
3.1
66
75
TLN1TLN1P26039P26039cell-celladhesioncell-substratejunctionassemblycorticalactincytoskeletonorganizationintegrinactivationintegrin-mediatedsignalingpathway
DNA-directed RNA polymerase III subunit RPC1
3.8
64
94
RPC1RPC1O14802O14802defenseresponsetovirusDNA-templatedtranscriptioninnateimmuneresponsepositiveregulationofinterferon-betaproduction
Interleukin-13
3.3
nan
86
IL13IL13P35225P35225cellularresponsetocytokinestimuluscellularresponsetomechanicalstimulusimmuneresponseinflammatoryresponsemacrophageactivationmicroglialcellactivationnegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofinflammatoryresponsenegativeregulationoflungciliatedcelldifferentiationnegativeregulationofNAD(P)HoxidaseactivitynegativeregulationofneurondeathnegativeregulationoftransforminggrowthfactorbetaproductionpositiveregulationofBcellproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofconnectivetissuegrowthfactorproductionpositiveregulationofgeneexpressionpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-10productionpositiveregulationoflunggobletcelldifferentiationpositiveregulationofmacrophageactivationpositiveregulationofmastcelldegranulationpositiveregulationofpancreaticstellatecellproliferationpositiveregulationofproteinsecretionpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofprotontransportresponsetoethanolresponsetolipopolysaccharideresponsetonicotine
Putative nucleotidyltransferase MAB21L1
4.2
62
78
MB211MB211Q13394Q13394anatomicalstructuremorphogenesiscamera-typeeyedevelopmentcellpopulationproliferationeyedevelopmentpositiveregulationofcellpopulationproliferation
E3 ubiquitin-protein ligase TRIM56
3.1
49
90
TRI56TRI56Q9BRZ2Q9BRZ2defenseresponsetovirusinnateimmuneresponsepositiveregulationofDNA-templatedtranscriptionpositiveregulationofinterferon-betaproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayproteinK63-linkedubiquitinationproteinmonoubiquitinationregulationoftypeIinterferonproductionresponsetotypeIinterferon
Ubiquitin thioesterase ZRANB1
3.3
50
89
ZRAN1ZRAN1A6QP16A6QP16cellmigrationcytoskeletonorganizationpositiveregulationofWntsignalingpathwayproteindeubiquitinationinvolvedinubiquitin-dependentproteincatabolicprocessproteinK29-linkeddeubiquitinationproteinK33-linkeddeubiquitinationproteinK63-linkeddeubiquitinationregulationofcellmorphogenesisWntsignalingpathway
CCR4-NOT transcription complex subunit 4
3.3
62
87
CNOT4CNOT4O95628O95628nuclear-transcribedmRNApoly(A)tailshorteningproteinautoubiquitinationproteinubiquitinationregulationofmegakaryocytedifferentiationubiquitin-dependentproteincatabolicprocess
Fatty acid-binding protein 5
3.1
65
82
FABP5FABP5Q01469Q01469epidermisdevelopmentfattyacidtransportglucosehomeostasisglucosemetabolicprocesslipidmetabolicprocesslipidtransportacrossblood-brainbarrierlong-chainfattyacidtransportnegativeregulationofglucosetransmembranetransportphosphatidylcholinebiosyntheticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwayregulationofprostaglandinbiosyntheticprocessregulationofretrogradetrans-synapticsignalingbyendocanabinoidregulationofsensoryperceptionofpain
Protein cereblon
2.0
49
90
TUSC3CRBNQ13454Q96SW2cognitionmagnesiumiontransportproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparaginetransmembranetransportlocomotoryexplorationbehaviornegativeregulationoflargeconductancecalcium-activatedpotassiumchannelactivitynegativeregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexassemblypositiveregulationofWntsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitination
Tyrosine-protein phosphatase non-receptor type 11
3.1
77
78
PTN11PTN11Q06124Q06124abortivemitoticcellcycleatrioventricularcanaldevelopmentaxonogenesisBergmannglialcelldifferentiationbraindevelopmentcellularresponsetoepidermalgrowthfactorstimuluscerebellarcortexformationcytokine-mediatedsignalingpathwayDNAdamagecheckpointsignalingephrinreceptorsignalingpathwayepidermalgrowthfactorreceptorsignalingpathwayERBBsignalingpathwayfacemorphogenesisfibroblastgrowthfactorreceptorsignalingpathwaygenitaliadevelopmentglucosehomeostasisheartdevelopmenthomeostasisofnumberofcellswithinatissuehormonemetabolicprocesshormone-mediatedsignalingpathwayinnereardevelopmentintegrin-mediatedsignalingpathwayintestinalepithelialcellmigrationmegakaryocytedevelopmentmicrovillusorganizationmulticellularorganismgrowthmulticellularorganismalreproductiveprocessnegativeregulationofcelladhesionmediatedbyintegrinnegativeregulationofchondrocytedifferentiationnegativeregulationofcortisolsecretionnegativeregulationofgrowthhormonesecretionnegativeregulationofinsulinsecretionneurotrophinTRKreceptorsignalingpathwayorgangrowthpeptidyl-tyrosinedephosphorylationplateletformationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofERK1andERK2cascadepositiveregulationofglucoseimportpositiveregulationofhormonesecretionpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofmitoticcellcyclepositiveregulationofossificationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftumornecrosisfactorproductionproteindephosphorylationregulationofcelladhesionmediatedbyintegrinregulationofproteinexportfromnucleusregulationofprotein-containingcomplexassemblyregulationoftypeIinterferon-mediatedsignalingpathwayTcellcostimulationtriglyceridemetabolicprocess
Protein disulfide-isomerase A6
3.1
46
88
✔
PDIA6PDIA6Q15084Q15084proteinfoldingresponsetoendoplasmicreticulumstress
RNA-binding protein FUS
3.1
45
89
FUSFUSP35637P35637amyloidfibrilformationmRNAstabilizationpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationproteinhomooligomerizationregulationofDNA-templatedtranscriptionregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseIIRNAsplicing
Protein phosphatase 1K, mitochondrial
3.1
67
80
PPM1KPPM1KQ8N3J5Q8N3J5peptidyl-threoninedephosphorylation
THAP domain-containing protein 1
3.3
65
92
THAP1THAP1Q9NVV9Q9NVV9cellcycleDNA-templatedtranscriptionendothelialcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationofmitoticcellcycleregulationoftranscriptionbyRNApolymeraseII
Obscurin-like protein 1
3.1
79
74
OBSL1OBSL1O75147O75147cardiacmyofibrilassemblycytoskeletonorganizationGolgiorganizationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesmicrotubulecytoskeletonorganizationpositiveregulationofdendritemorphogenesisproteinlocalizationtoGolgiapparatusregulationofmitoticnucleardivisionretinalayerformationsynapseassembly
Nuclear receptor subfamily 4 group A member 2
3.5
nan
99
NR4A2NR4A2P43354P43354adultlocomotorybehaviorcanonicalWntsignalingpathwaycellularresponsetocorticotropin-releasinghormonestimuluscellularresponsetoextracellularstimuluscellularresponsetooxidativestresscentralnervoussystemneurondifferentiationcentralnervoussystemprojectionneuronaxonogenesisDNA-templatedtranscriptiondopaminebiosyntheticprocessdopaminergicneurondifferentiationfatcelldifferentiationgeneraladaptationsyndromehabenuladevelopmentmidbraindopaminergicneurondifferentiationnegativeregulationofapoptoticsignalingpathwaynegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuronapoptoticprocessneuronmaturationneuronmigrationpositiveregulationofcatalyticactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicdevelopmentregulationofdopaminemetabolicprocessregulationofrespiratorygaseousexchangeregulationoftranscriptionbyRNApolymeraseIIresponsetoamphetamineresponsetohypoxiasignaltransductiontranscriptionbyRNApolymeraseII
CD83 antigen
3.1
66
80
CD83CD83Q01151Q01151CD4-positivealpha-betaTcelldifferentiationdefenseresponsehumoralimmuneresponsenegativeregulationofinterleukin-4productionpositiveregulationofCD4-positivealpha-betaTcelldifferentiationpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-2productionresponsetoorganiccycliccompoundsignaltransduction
Non-structural maintenance of chromosomes element 1 homolog
3.9
46
93
NSE1NSE1Q8WV22Q8WV22double-strandbreakrepairviahomologousrecombinationpositiveregulationofresponsetoDNAdamagestimuluspostreplicationrepairproteinsumoylationregulationoftelomeremaintenance
Cytoplasmic polyadenylation element-binding protein 1
3.2
50
82
CPEB1CPEB1Q9BZB8Q9BZB8cellularresponsetoaminoacidstimuluscellularresponsetohypoxiacellularresponsetoinsulinstimulusmRNAprocessingnegativeregulationofcytoplasmictranslationpositiveregulationofmRNApolyadenylation
3-hydroxy-3-methylglutaryl-coenzyme A reductase
4.6
67
65
HMDHHMDHP00347P00347cholesterolbiosyntheticprocesscoenzymeAmetabolicprocessisoprenoidbiosyntheticprocessnegativeregulationofamyloid-betaclearancenegativeregulationofMAPkinaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionvisuallearning
Filamin-A
2.1
nan
89
✔
FLNAFLNAP21333P21333actincrosslinkformationactincytoskeletonreorganizationadenylatecyclase-inhibitingdopaminereceptorsignalingpathwayangiogenesisbloodcoagulationintrinsicpathwaybloodvesselremodelingcell-celljunctionorganizationciliumassemblycytoplasmicsequesteringofproteinearlyendosometolateendosometransportepithelialtomesenchymaltransitionestablishmentofproteinlocalizationheartmorphogenesismegakaryocytedevelopmentmitoticspindleassemblynegativeregulationofapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofneuronprojectiondevelopmentnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIplateletaggregationpositiveregulationofaxonregenerationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofplateletactivationpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofproteinimportintonucleuspositiveregulationofsubstrateadhesion-dependentcellspreadingproteinlocalizationtocellsurfaceproteinlocalizationtoplasmamembraneproteinstabilizationreceptorclusteringregulationofactinfilamentbundleassemblyregulationofcellmigrationregulationofmembranerepolarizationduringatrialcardiacmusclecellactionpotentialregulationofmembranerepolarizationduringcardiacmusclecellactionpotentialreleaseofsequesteredcalciumionintocytosolsemaphorin-plexinsignalingpathwaysynapseorganizationtubulindeacetylationwoundhealingspreadingofcells
Maternal embryonic leucine zipper kinase
2.0
57
84
✔
MELKMELKQ14680Q14680apoptoticprocesscellpopulationproliferationG2/Mtransitionofmitoticcellcyclehemopoiesisintracellularsignaltransductionintrinsicapoptoticsignalingpathwayinresponsetooxidativestressneuralprecursorcellproliferationpositiveregulationofapoptoticprocessproteinautophosphorylationproteinphosphorylation
Ferrochelatase, mitochondrial
3.6
63
82
HEMHHEMHP22830P22830cholesterolmetabolicprocessdetectionofUVerythrocytedifferentiationgenerationofprecursormetabolitesandenergyhemebiosyntheticprocessironionhomeostasisprotoporphyrinogenIXmetabolicprocessregulationofeIF2alphaphosphorylationbyhemeregulationofhemoglobinbiosyntheticprocessresponsetolightstimulusvery-low-densitylipoproteinparticleassembly
Proliferating cell nuclear antigen
3.1
72
80
PCNAPCNAP12004P12004base-excisionrepairgap-fillingcellularresponsetohydrogenperoxidecellularresponsetoUVcellularresponsetoxenobioticstimulusepithelialcelldifferentiationestrouscycleheartdevelopmentleadingstrandelongationliverregenerationmismatchrepairmitotictelomeremaintenanceviasemi-conservativereplicationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofdeoxyribonucleaseactivitypositiveregulationofDNArepairpositiveregulationofDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivityreplicationforkprocessingresponsetocadmiumionresponsetodexamethasoneresponsetoestradiolresponsetoL-glutamatetranslesionsynthesis
Cellular tumor antigen p53
3.9
56
81
P53P53P04637P04637autophagyBcelllineagecommitmentbonemarrowdevelopmentcardiacmusclecellapoptoticprocesscardiacseptummorphogenesiscellularresponsetoactinomycinDcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetoglucosestarvationcellularresponsetohypoxiacellularresponsetoionizingradiationcellularresponsetoUVcellularresponsetoUV-CcellularresponsetoxenobioticstimuluscellularsenescencecerebellumdevelopmentchromosomeorganizationcircadianbehaviordeterminationofadultlifespanDNAdamageresponsesignaltransductionbyp53classmediatorDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatordouble-strandbreakrepairembryonicorgandevelopmententrainmentofcircadianclockbyphotoperiodERoverloadresponsefibroblastproliferationgastrulationglialcellproliferationglucosecatabolicprocesstolactateviapyruvatehematopoieticprogenitorcelldifferentiationhematopoieticstemcelldifferentiationinuteroembryonicdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetohypoxiamitochondrialDNArepairmitophagymitoticG1DNAdamagecheckpointsignalingmRNAtranscriptionmulticellularorganismgrowthnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNAreplicationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoffibroblastproliferationnegativeregulationofG1toG0transitionnegativeregulationofglialcellproliferationnegativeregulationofglucosecatabolicprocesstolactateviapyruvatenegativeregulationofhelicaseactivitynegativeregulationofmiRNAmaturationnegativeregulationofmitophagynegativeregulationofneuroblastproliferationnegativeregulationofpentose-phosphateshuntnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofstemcellproliferationnegativeregulationoftelomeraseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayneuroblastproliferationneuronapoptoticprocessnucleotide-excisionrepairoligodendrocyteapoptoticprocessoxidativestress-inducedprematuresenescencepositiveregulationofapoptoticprocesspositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellularsenescencepositiveregulationofDNA-templatedtranscriptionpositiveregulationofexecutionphaseofapoptosispositiveregulationofgeneexpressionpositiveregulationofhistonedeacetylationpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmitochondrialmembranepermeabilitypositiveregulationofneuronapoptoticprocesspositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofprogrammednecroticcelldeathpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreleaseofcytochromecfrommitochondriapositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblypositiveregulationofthymocyteapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoendoplasmicreticulumstresspositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetostressproteinimportintonucleusproteinlocalizationproteinstabilizationproteintetramerizationprotein-containingcomplexassemblyRasproteinsignaltransductionreactiveoxygenspeciesmetabolicprocessregulationofapoptoticprocessregulationofcellcycleregulationofcellcycleG2/MphasetransitionregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationofDNA-templatedtranscriptionregulationoffibroblastapoptoticprocessregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationoftissueremodelingregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoDNAdamagereleaseofcytochromecfrommitochondriareplicativesenescenceresponsetoantibioticresponsetogammaradiationresponsetoinorganicsubstanceresponsetoischemiaresponsetosaltstressresponsetoX-rayrRNAtranscriptionsignaltransductionbyp53classmediatorsomitogenesisstemcellproliferationTcelldifferentiationinthymusTcelllineagecommitmentTcellproliferationinvolvedinimmuneresponsethymocyteapoptoticprocesstranscriptioninitiation-coupledchromatinremodelingtransforminggrowthfactorbetareceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwaytypeIIinterferon-mediatedsignalingpathwayviralprocess
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
3.2
40
93
✔
SIR3SIR3Q9NTG7Q9NTG7aerobicrespirationpeptidyl-lysinedeacetylationpositiveregulationofcatalaseactivitypositiveregulationofceramidebiosyntheticprocesspositiveregulationofsuperoxidedismutaseactivityproteindeacetylation
Lysine-specific demethylase 5B
3.5
46
90
KDM5BKDM5BQ9UGL1Q9UGL1branchinginvolvedinmammaryglandductmorphogenesiscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetoleukemiainhibitoryfactorchromatinremodelinghistonelysinedemethylationlensfibercelldifferentiationmammaryductterminalendbudgrowthnegativeregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofmammaryglandepithelialcellproliferationpost-embryonicdevelopmentregulationofestradiolsecretionresponsetofungiciderhythmicprocesssinglefertilizationuterusmorphogenesis
Interleukin-12 subunit beta
2.0
nan
91
IL12BIL12BP43432P43432cellmigrationcellpopulationproliferationcellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharidecellularresponsetotypeIIinterferoncytokine-mediatedsignalingpathwaydefenseresponsetoGram-negativebacteriumdefenseresponsetoprotozoandefenseresponsetovirusimmuneresponsenaturalkillercellactivationnaturalkillercellactivationinvolvedinimmuneresponsenegativeregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesisnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-17productionnegativeregulationofproteinsecretionnegativeregulationofsmoothmusclecellproliferationnegativeregulationofvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofactivatedTcellproliferationpositiveregulationofactivationofJanuskinaseactivitypositiveregulationofcelladhesionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationoflymphocyteproliferationpositiveregulationofmononuclearcellproliferationpositiveregulationofnaturalkillercellactivationpositiveregulationofnaturalkillercellmediatedcytotoxicitydirectedagainsttumorcelltargetpositiveregulationofnaturalkillercellproliferationpositiveregulationofNKTcellactivationpositiveregulationofNKTcellproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationoftyrosinephosphorylationofSTATproteinresponsetoorganicsubstanceresponsetoUV-BsensoryperceptionofpainTcellproliferationT-helpercelldifferentiation
Thioredoxin, mitochondrial
3.1
75
77
✔
THIOMTHIOMQ99757Q99757cellredoxhomeostasiscellularresponsetonutrientlevelsresponsetoaxoninjuryresponsetoglucoseresponsetohormoneresponsetohypoxiaresponsetoorganiccycliccompoundresponsetooxidativestressresponsetoxenobioticstimulus
Structural maintenance of chromosomes protein 3
3.1
83
77
SMC3SMC3Q9CW03Q9CW03celldivisionDNArepairmeioticcellcyclemitoticsisterchromatidcohesionmitoticspindleassemblyregulationofDNAreplicationsisterchromatidcohesionstemcellpopulationmaintenance
Tyrosine-protein kinase BTK
3.1
48
85
BTKBTKQ06187Q06187adaptiveimmuneresponseapoptoticsignalingpathwayBcellactivationBcellaffinitymaturationBcellreceptorsignalingpathwaycalcium-mediatedsignalingcellmaturationcellularresponsetointerleukin-7cellularresponsetomoleculeoffungalorigincellularresponsetoreactiveoxygenspecieseosinophilhomeostasisFc-epsilonreceptorsignalingpathwayhistaminesecretionbymastcellI-kappaBkinase/NF-kappaBsignalinginnateimmuneresponseintracellularsignaltransductionmesodermdevelopmentmonocyteproliferationMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofBcellproliferationnegativeregulationofinterleukin-10productionneutrophilhomeostasispeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofBcelldifferentiationpositiveregulationofBcellproliferationpositiveregulationofimmunoglobulinproductionpositiveregulationofinterleukin-17Aproductionpositiveregulationofinterleukin-6productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofphagocytosispositiveregulationofsynoviocyteproliferationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIIhypersensitivityproteinphosphorylationproteoglycancatabolicprocessregulationofBcellapoptoticprocessregulationofBcellcytokineproductionresponsetolipopolysaccharide
Casein kinase II subunit beta
3.4
54
87
CSK2BCSK2BP67874P67874adiponectin-activatedsignalingpathwayendothelialtubemorphogenesisliverregenerationnegativeregulationofbloodvesselendothelialcellmigrationpeptidyl-threoninephosphorylationpositiveregulationofactivinreceptorsignalingpathwaypositiveregulationofpathway-restrictedSMADproteinphosphorylationproteinphosphorylationregulationofproteinserine/threoninephosphataseactivityresponsetotestosteroneWntsignalingpathway
Protein transport protein Sec23A
3.3
61
91
✔
SC23ASC23AQ15436Q15436COPII-coatedvesiclecargoloadingintracellularproteintransportproteinlocalizationtoplasmamembrane
GMP reductase 2
3.1
60
78
GMPR2GMPR2Q9P2T1Q9P2T1GMPmetabolicprocesspurinenucleobasemetabolicprocess
Ubiquitin-conjugating enzyme E2 D2
3.2
65
84
UB2D2UB2D2P62837P62837proteinautoubiquitinationproteinK48-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
Arf-GAP with dual PH domain-containing protein 1
3.2
76
76
ADAP1ADAP1O75689O75689cellsurfacereceptorsignalingpathwaypositiveregulationofGTPaseactivityregulationofGTPaseactivity
DNA-directed RNA polymerases I, II, and III subunit RPABC4
3.4
42
86
RPAB4RPAB4Q3ZBC0Q3ZBC0transcriptionbyRNApolymeraseII
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
3.4
63
75
F1SCH1F1SCH1F1SCH1F1SCH1mitochondrialrespiratorychaincomplexIassembly
E3 ubiquitin-protein ligase TRIM33
3.6
52
84
TRI33TRI33Q9UPN9Q9UPN9negativeregulationofBMPsignalingpathwaynegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIproteinubiquitinationregulationoftransforminggrowthfactorbetareceptorsignalingpathway
tRNA (cytosine(72)-C(5))-methyltransferase NSUN6
3.2
70
75
NSUN6NSUN6Q8TEA1Q8TEA1RNAmethylationtRNAC5-cytosinemethylationtRNAmethylationtRNAmodification
Lysine-specific histone demethylase 2
3.3
78
90
KDM1BKDM1BQ8NB78Q8NB78DNAmethylationinvolvedingametegenerationhistoneH3-K4demethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNAmethylationregulationofgeneexpressionbygenomicimprinting
Aldehyde oxidase
3.2
99
70
AOXAAOXAQ06278Q06278lipidmetabolicprocessxenobioticmetabolicprocess
Transforming acidic coiled-coil-containing protein 3
3.2
61
78
✔
TACC3TACC3Q9Y6A5Q9Y6A5celldivisioncellpopulationproliferationcerebralcortexdevelopmentmetaphase/anaphasetransitionofmitoticcellcyclemicrotubulecytoskeletonorganizationmicrotubulecytoskeletonorganizationinvolvedinmitosismitoticspindleorganizationregulationofmitoticspindleorganization
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
3.2
51
80
PAPS1PAPS1O43252O43252"3-phosphoadenosine5-phosphosulfatebiosyntheticprocess"phosphorylationskeletalsystemdevelopmentsulfateassimilation
Histone-lysine N-methyltransferase ASH1L
3.8
68
95
ASH1LASH1LQ9NR48Q9NR48chromatinorganizationdecidualizationflagellatedspermmotilityhistoneH3-K36dimethylationhistoneH3-K4methylationI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseMAPKcascadenegativeregulationofacuteinflammatoryresponsenegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofMAPKcascadepositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicdevelopmentregulationofDNA-templatedtranscriptionsinglefertilizationskeletalsystemdevelopmenttarsalglanddevelopmenttranscriptionbyRNApolymeraseIIuterineglanddevelopmentuterusmorphogenesis
Ephrin type-A receptor 7
2.0
56
87
EPHA7EPHA7B7ZLK0B7ZLK0axonguidancebraindevelopmentbranchingmorphogenesisofanerveephrinreceptorsignalingpathwaymodulationofchemicalsynaptictransmissionnegativechemotaxisnegativeregulationofcollateralsproutingnegativeregulationofsynapseassemblynephricductmorphogenesisneuronapoptoticprocessphosphorylationpositiveregulationofkinaseactivitypositiveregulationofneuronapoptoticprocesspositiveregulationofproteinphosphorylationregulationofcell-celladhesionregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessregulationofERK1andERK2cascaderegulationofpeptidyl-tyrosinephosphorylationregulationofpostsynapseorganizationregulationofproteinautophosphorylationretinalganglioncellaxonguidancetransmembranereceptorproteintyrosinekinasesignalingpathway
Actin-related protein 2/3 complex subunit 1B
3.2
58
78
ARC1BARC1BQ58CQ2Q58CQ2Arp2/3complex-mediatedactinnucleation
E3 ubiquitin-protein ligase RBX1
3.4
64
97
RBX1RBX1P62877P62877cellularresponsetochemicalstresscellularresponsetoDNAdamagestimuluscellularresponsetoUVDNArepairMAPKcascadenegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinautoubiquitinationpost-translationalproteinmodificationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinmonoubiquitinationproteinneddylationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocess
NF-kappa-B essential modulator
3.8
39
89
NEMONEMOQ9Y6K9Q9Y6K9anoikisapoptoticprocesscellularresponsetoDNAdamagestimulusestablishmentofvesiclelocalizationI-kappaBkinase/NF-kappaBsignalingimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofneurondeathpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmacroautophagypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationofI-kappaBkinase/NF-kappaBsignalingresponsetovirusTcellreceptorsignalingpathway
rRNA N6-adenosine-methyltransferase ZCCHC4
3.2
39
93
ZCHC4ZCHC4Q9H5U6Q9H5U6positiveregulationoftranslationrRNAmethylation
E3 ubiquitin-protein ligase RNF4
3.5
36
84
RNF4RNF4O88846O88846cellularresponsetoarsenic-containingsubstancecellularresponsetocytokinestimuluscellularresponsetogammaradiationcellularresponsetohydroxyureacellularresponsetotestosteronestimulusmalegonaddevelopmentnegativeregulationofcelldeathpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinK11-linkedubiquitinationproteinK48-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinubiquitinationregulationofkinetochoreassemblyregulationofspindleassemblyresponsetoarsenic-containingsubstanceresponsetoestradiolresponsetohumanchorionicgonadotropinspermatogenesis
CDGSH iron-sulfur domain-containing protein 2
3.2
88
76
CISD2CISD2Q8N5K1Q8N5K1autophagyofmitochondrionregulationofautophagy
Alpha-ketoglutarate-dependent dioxygenase FTO
3.2
68
81
FTOFTOQ9C0B1Q9C0B1adiposetissuedevelopmentDNAdealkylationinvolvedinDNArepairDNAdemethylationmRNAdestabilizationoxidativedemethylationoxidativesingle-strandedDNAdemethylationoxidativesingle-strandedRNAdemethylationregulationofbrownfatcelldifferentiationregulationoflipidstorageregulationofmulticellularorganismgrowthregulationofrespiratorysystemprocessregulationofwhitefatcellproliferationRNArepairtemperaturehomeostasis
Alpha-L-iduronidase
3.2
91
72
IDUAIDUAP35475P35475chondroitinsulfatecatabolicprocessdermatansulfatecatabolicprocessdisaccharidemetabolicprocessheparansulfateproteoglycancatabolicprocessheparincatabolicprocess
Histone-lysine N-methyltransferase EHMT1
3.2
65
91
EHMT1EHMT1Q9H9B1Q9H9B1chromatinorganizationDNAmethylationfacultativeheterochromatinformationhistoneH3-K9methylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-lysinedimethylationpeptidyl-lysinemonomethylationpositiveregulationofcold-inducedthermogenesisregulationofembryonicdevelopmentregulationofhistoneH3-K9methylation
Four and a half LIM domains protein 3
3.2
54
91
FHL3FHL3Q13643Q13643actincytoskeletonorganizationmuscleorgandevelopment
Wilms tumor protein
3.2
39
92
WT1WT1Q4VXV4Q4VXV4adrenalcortexformationadrenalglanddevelopmentbranchinginvolvedinuretericbudmorphogenesiscamera-typeeyedevelopmentcardiacmusclecellfatecommitmentcellularresponsetocAMPcellularresponsetogonadotropinstimulusdiaphragmdevelopmentepithelialcelldifferentiationgermcelldevelopmentglomerularbasementmembranedevelopmentglomerulusdevelopmentgonaddevelopmentheartdevelopmentkidneydevelopmentmalegenitaliadevelopmentmalegonaddevelopmentmesenchymaltoepithelialtransitionmetanephricepitheliumdevelopmentmetanephricmesenchymedevelopmentmetanephricS-shapedbodymorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoffemalegonaddevelopmentnegativeregulationofmetanephricglomerularmesangialcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranslationpodocytedifferentiationpositiveregulationofapoptoticprocesspositiveregulationofDNAmethylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofheartgrowthpositiveregulationofmalegonaddevelopmentpositiveregulationofmetanephricuretericbuddevelopmentpositiveregulationofmiRNAtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIposteriormesonephrictubuledevelopmentregulationofanimalorganformationregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIRNAsplicingsexdeterminationthoraxandanteriorabdomendeterminationtissuedevelopmenturetericbuddevelopmentvasculogenesisvisceralserouspericardiumdevelopment
C->U-editing enzyme APOBEC-1
3.2
62
85
ABEC1ABEC1P41238P41238cytidinetouridineeditingDNAdemethylationestablishmentoflocalizationincelllipidmetabolicprocesslipoproteinbiosyntheticprocesslipoproteintransportmRNAmodificationmRNAprocessingmRNAstabilizationnegativeregulationofDNAmethylation-dependentheterochromatinformationnegativeregulationofnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaynegativeregulationoftriglyceridemetabolicprocesspositiveregulationofDNAdemethylationregulationofcellpopulationproliferationresponsetogammaradiationtriglyceridemetabolicprocess
DNA-directed RNA polymerases I, II, and III subunit RPABC5
4.0
85
75
RPAB5RPAB5Q32P78Q32P78transcriptionbyRNApolymeraseItranscriptionbyRNApolymeraseIItRNAtranscriptionbyRNApolymeraseIII
DNA (cytosine-5)-methyltransferase 3A
4.0
64
86
DNM3ADNM3AQ9Y6K1Q9Y6K1agingC-5methylationofcytosinecellularresponsetoaminoacidstimuluscellularresponsetobisphenolAcellularresponsetoethanolcellularresponsetohypoxiaDNAmethylationDNAmethylationinvolvedinembryodevelopmentDNAmethylationinvolvedingametegenerationDNAmethylationoncytosineDNAmethylation-dependentheterochromatinformationhepatocyteapoptoticprocessmitoticcellcyclenegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationpositiveregulationofcelldeathregulationofgeneexpressionbygenomicimprintingresponsetococaineresponsetoestradiolresponsetoionizingradiationresponsetoleadionresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulusspermatogenesis
Polyamine-transporting ATPase 13A2
3.9
44
78
AT132AT132Q9NQ11Q9NQ11autophagosomeorganizationautophagosome-lysosomefusionautophagycellularcalciumionhomeostasiscellularcationhomeostasiscellularironionhomeostasiscellularresponsetomanganeseioncellularresponsetooxidativestresscellularresponsetozincioncellularzincionhomeostasisextracellularexosomebiogenesisiontransmembranetransportlipidhomeostasislysosomaltransportnegativeregulationoflysosomalproteincatabolicprocessnegativeregulationofneurondeathpeptidyl-asparticacidautophosphorylationpolyaminetransmembranetransportpositiveregulationofexosomalsecretionpositiveregulationofgeneexpressionpositiveregulationofproteinsecretionproteinautophosphorylationproteinlocalizationtolysosomeregulationofautophagosomesizeregulationofautophagyofmitochondrionregulationofchaperone-mediatedautophagyregulationofendopeptidaseactivityregulationofglucosylceramidaseactivityregulationofintracellularproteintransportregulationoflysosomalproteincatabolicprocessregulationofmacroautophagyregulationofmitochondrionorganizationregulationofproteinlocalizationtonucleusregulationofubiquitin-specificproteaseactivitysperminetransmembranetransporttransmembranetransport
General transcription factor IIH subunit 2
4.4
68
90
TF2H2TF2H2Q13888Q13888Gprotein-coupledreceptorinternalizationnucleotide-excisionrepairpositiveregulationofDNAhelicaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoUVtranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoter
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
3.2
77
75
DYR1ADYR1AQ13627Q13627amyloid-betaformationcircadianrhythmnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofDNAmethylation-dependentheterochromatinformationnegativeregulationofmicrotubulepolymerizationnegativeregulationofmRNAsplicingviaspliceosomenervoussystemdevelopmentpeptidyl-serineautophosphorylationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteindeacetylationpositiveregulationofRNAsplicingproteinautophosphorylationproteinphosphorylation
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
3.5
53
91
RUBICRUBICQ92622Q92622autophagyendocytosisimmunesystemprocessmultivesicularbodysortingpathwaynegativeregulationofautophagosomematurationnegativeregulationofautophagynegativeregulationofendocytosisnegativeregulationofphosphatidylinositol3-kinaseactivityphagocytosis
Calcium-transporting ATPase
4.0
46
79
B6CAM1B6CAM1B6CAM1B6CAM1
E3 ubiquitin-protein ligase UHRF1
3.2
46
93
UHRF1UHRF1Q96T88Q96T88cellcyclechromatinorganizationDNArepairhistonemonoubiquitinationhistoneubiquitinationmaintenanceofDNAmethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAtopoisomerase(ATP-hydrolyzing)activitypositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteinautoubiquitinationproteinubiquitinationregulationofepithelialcellproliferationubiquitin-dependentproteincatabolicprocess
E3 ubiquitin-protein ligase LNX
4.0
49
86
LNX1LNX1Q8TBB1Q8TBB1ubiquitin-dependentproteincatabolicprocess
Baculoviral IAP repeat-containing protein 6
3.2
71
83
BIRC6BIRC6Q9NR09Q9NR09apoptoticprocesscellcyclecelldivisioncellpopulationproliferationlabyrinthinelayerdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofpeptidaseactivitypositiveregulationofcellpopulationproliferationproteinphosphorylationproteinubiquitinationregulationofcellpopulationproliferationregulationofcytokinesisregulationofendopeptidaseactivityspongiotrophoblastlayerdevelopment
Histone-lysine N-methyltransferase EHMT2
3.7
72
94
EHMT2EHMT2Q96KQ7Q96KQ7behavioralresponsetococainecellularresponsetococainecellularresponsetostarvationcellularresponsetoxenobioticstimuluschromatinorganizationDNAmethylationDNAmethylationoncytosinewithinaCGsequencefertilizationhistoneH3-K9methylationhistonelysinemethylationlong-termmemorynegativeregulationofautophagosomeassemblynegativeregulationoftranscriptionbyRNApolymeraseIIneuronfatespecificationoocytedevelopmentorgangrowthpeptidyl-lysinedimethylationphenotypicswitchingregulationofDNAmethylationregulationofDNAreplicationregulationofhistoneH3-K9methylationresponsetoethanolresponsetofungicidespermatiddevelopmentsynaptonemalcomplexassembly
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
3.5
68
77
I3LGM4I3LGM4I3LGM4I3LGM4mitochondrialrespiratorychaincomplexIassembly
Actin, cytoplasmic 1
2.0
nan
88
ACTBACTBP60712P60712adherensjunctionassemblyapicalproteinlocalizationaxonogenesiscellmotilitycellularresponsetocytochalasinBestablishmentormaintenanceofcellpolarityhistoneH2AacetylationhistoneH4acetylationmorphogenesisofapolarizedepitheliumnegativeregulationofproteinbindingpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationproteinlocalizationtoadherensjunctionregulationofcellcycleregulationofnorepinephrineuptakeregulationofproteinlocalizationtoplasmamembraneregulationofsynapticvesicleendocytosisregulationoftransepithelialtransportregulationoftransmembranetransporteractivity
Programmed cell death protein 1
3.2
82
75
PDCD1PDCD1Q15116Q15116adaptiveimmuneresponseapoptoticprocessBcellapoptoticprocesshumoralimmuneresponsenegativeregulationofBcellapoptoticprocessnegativeregulationofimmuneresponsenegativeregulationoftoleranceinductionpositiveregulationofTcellapoptoticprocessregulationofimmuneresponseregulatoryTcellapoptoticprocess
DNA repair protein XRCC4
3.2
70
77
XRCC4XRCC4Q13426Q13426DNAligationinvolvedinDNArepairdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)Jrecombinationpositiveregulationofligaseactivitypositiveregulationofphosphatidylserineexposureonapoptoticcellsurfaceproteinlocalizationtositeofdouble-strandbreakresponsetoX-ray
SUMO-activating enzyme subunit 2
3.6
66
82
SAE2SAE2Q9UBT2Q9UBT2positiveregulationofproteinsumoylationproteinmodificationbysmallproteinconjugationproteinsumoylation
E3 ubiquitin-protein ligase CBL-B
3.2
42
90
CBLBCBLBQ13191Q13191CD4-positivealpha-betaTcellproliferationimmuneresponseintracellularsignaltransductionnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofepidermalgrowthfactor-activatedreceptoractivitynegativeregulationofTcellreceptorsignalingpathwayNLS-bearingproteinimportintonucleuspeptidyl-aminoacidmodificationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinubiquitinationpositiveregulationofTcellanergyproteincatabolicprocessregulationofGTPaseactivityregulationofplatelet-derivedgrowthfactorreceptor-alphasignalingpathwayregulationofproteinbindingsignaltransductionTcellanergyTcellreceptorsignalingpathway
Polycomb group RING finger protein 6
4.0
46
89
PCGF6PCGF6Q9BYE7Q9BYE7histoneH2A-K119monoubiquitinationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
E3 ubiquitin-protein ligase RNF144A
3.8
39
90
R144AR144AP50876P50876positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
Protein disulfide-isomerase A3
3.2
43
85
✔
PDIA3PDIA3P30101P30101cellularresponsetointerleukin-7extrinsicapoptoticsignalingpathwaypeptideantigenassemblywithMHCclassIproteincomplexpositiveregulationofextrinsicapoptoticsignalingpathwayproteinfoldingproteinfoldinginendoplasmicreticulumresponsetoendoplasmicreticulumstress
TNF receptor-associated factor 5
3.2
43
90
TRAF5TRAF5O00463O00463apoptoticprocessinterleukin-17-mediatedsignalingpathwaymRNAstabilizationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofJNKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivityproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingsignaltransductionsignaltransductioninvolvedinregulationofgeneexpressiontumornecrosisfactor-mediatedsignalingpathway
Sodium/calcium exchanger 1
2.7
81
78
NAC1NAC1P23685P23685calciumionimportcalciumionimportacrossplasmamembranecalciumiontransmembranetransportcellcommunicationcellularsodiumionhomeostasismetaliontransportpositiveregulationofbonemineralizationpositiveregulationoftheforceofheartcontractionresponsetomusclestretchsodiumionimportacrossplasmamembranesodiumiontransmembranetransport
Protein transport protein Sec24A
3.3
56
88
SC24ASC24AO95486O95486cholesterolhomeostasisCOPII-coatedvesiclecargoloadingendoplasmicreticulumtoGolgivesicle-mediatedtransportintracellularproteintransportpositiveregulationofproteinsecretionregulationofcholesteroltransport
Leucine-rich repeat-containing protein 4
3.2
73
79
LRRC4LRRC4Q9HBW1Q9HBW1excitatorysynapseassemblymodulationofchemicalsynaptictransmissionpostsynapticdensityprotein95clusteringsynapticmembraneadhesion
DNA damage-binding protein 2
3.2
33
89
✔
DDB2DDB2Q92466Q92466cellularresponsetoDNAdamagestimuluscellularresponsetoUVDNArepairhistoneH2Amonoubiquitinationnucleotide-excisionrepairproteinautoubiquitinationproteinpolyubiquitinationpyrimidinedimerrepairresponsetoUVUV-damageexcisionrepair
Immunoglobulin heavy constant epsilon
4.3
71
78
IGHEIGHEP01854P01854adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Inhibitor of growth protein 4
3.2
49
89
ING4ING4Q8C0D7Q8C0D7apoptoticprocesscellcycleDNAreplication-dependentchromatindisassemblyhistoneH4-K12acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationhistonemodificationnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgrowthpositiveregulationofapoptoticprocesspositiveregulationofDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorproteinacetylationregulationofcellcycleregulationofcellcycleG2/MphasetransitionregulationofcellgrowthregulationofDNAbiosyntheticprocessregulationofDNA-templatedtranscription
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
3.6
86
81
PDE10PDE10Q9Y233Q9Y233cAMPcatabolicprocesscGMPcatabolicprocessnegativeregulationofcGMP-mediatedsignalingsignaltransduction
Regulator of nonsense transcripts 1
3.4
61
90
RENT1RENT1Q92900Q92900"3-UTR-mediatedmRNAdestabilization"cellcyclephasetransitioncellularresponsetointerleukin-1cellularresponsetolipopolysaccharideDNAduplexunwindingDNArepairDNAreplicationhistonemRNAcatabolicprocessmRNAexportfromnucleusnuclear-transcribedmRNAcatabolicprocessnuclear-transcribedmRNAcatabolicprocessendonucleolyticcleavage-dependentdecaynuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaypositiveregulationofmRNAcatabolicprocessregulationoftelomeremaintenanceregulationoftranslationalterminationtelomeremaintenanceviasemi-conservativereplication
PHD finger protein 24
3.2
43
87
PHF24PHF24Q9UPV7Q9UPV7detectionofmechanicalstimulusinvolvedinsensoryperceptionofpaingamma-aminobutyricacidsignalingpathwayregulationofGprotein-coupledreceptorsignalingpathwayregulationofsynaptictransmissionGABAergic
Hexokinase-2
3.2
79
75
HXK2HXK2P52789P52789apoptoticmitochondrialchangescanonicalglycolysiscarbohydratephosphorylationcellularglucosehomeostasiscellularresponsetoleukemiainhibitoryfactorestablishmentofproteinlocalizationtomitochondrionfructose6-phosphatemetabolicprocessglucose6-phosphatemetabolicprocessglucosemetabolicprocessglycolyticprocesslactationmaintenanceofproteinlocationinmitochondrionnegativeregulationofmitochondrialmembranepermeabilitynegativeregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrioninresponsetomitochondrialdepolarizationregulationofglucoseimportresponsetohypoxiaresponsetoischemia
Polyhomeotic-like protein 1
3.3
47
93
PHC1PHC1P78364P78364histoneubiquitinationnegativeregulationofDNA-templatedtranscription
MHC class I antigen
3.4
77
75
A0A411J078A0A411J078A0A411J078A0A411J078
Transcription factor COE1
3.1
26
89
COE1COE1Q07802Q07802positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Tyrosine-protein kinase JAK2
3.2
50
80
JAK2JAK2O60674O60674actinfilamentpolymerizationactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivationofJanuskinaseactivityadaptiveimmuneresponseapoptoticprocessaxonregenerationcelldifferentiationcellularresponsetodexamethasonestimuluscellularresponsetointerleukin-3cellularresponsetolipopolysaccharidecellularresponsetoviruschromatinorganizationcollagen-activatedsignalingpathwaycytokine-mediatedsignalingpathwayenzyme-linkedreceptorproteinsignalingpathwayerythrocytedifferentiationextrinsicapoptoticsignalingpathwayGprotein-coupledreceptorsignalingpathwaygranulocyte-macrophagecolony-stimulatingfactorsignalingpathwaygrowthhormonereceptorsignalingpathwaygrowthhormonereceptorsignalingpathwayviaJAK-STATimmuneresponseinterleukin-12-mediatedsignalingpathwayinterleukin-35-mediatedsignalingpathwayinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionintrinsicapoptoticsignalingpathwayinresponsetooxidativestressmammaryglandepitheliumdevelopmentmesodermdevelopmentmicroglialcellactivationmineralocorticoidreceptorsignalingpathwaymodulationofchemicalsynaptictransmissionnegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionnegativeregulationofDNAbindingnegativeregulationofheartcontractionnegativeregulationofneuronapoptoticprocesspeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticsignalingpathwaypositiveregulationofcelldifferentiationpositiveregulationofcellmigrationpositiveregulationofcell-substrateadhesionpositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialcellapoptoticprocesspositiveregulationofgrowthfactordependentskeletalmusclesatellitecellproliferationpositiveregulationofgrowthhormonereceptorsignalingpathwaypositiveregulationofinflammatoryresponsepositiveregulationofinsulinsecretionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-17productionpositiveregulationofleukocyteproliferationpositiveregulationofMAPKcascadepositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofnaturalkillercellproliferationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNKTcellproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofplateletactivationpositiveregulationofplateletaggregationpositiveregulationofproteinimportintonucleuspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsignalingreceptoractivitypositiveregulationofSMADproteinsignaltransductionpositiveregulationofTcellproliferationpositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationpost-embryonichemopoiesispost-translationalproteinmodificationprogrammedcelldeathinducedbysymbiontproteinautophosphorylationproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofapoptoticprocessregulationofinflammatoryresponseregulationofnitricoxidebiosyntheticprocessregulationofpostsynapsetonucleussignalingpathwayregulationofreceptorsignalingpathwayviaJAK-STATresponsetoamineresponsetoantibioticresponsetohydroperoxideresponsetointerleukin-12responsetolipopolysaccharideresponsetotumornecrosisfactorsignaltransductiontranscriptionbyRNApolymeraseIItumornecrosisfactor-mediatedsignalingpathwaytypeIIinterferon-mediatedsignalingpathwaytyrosinephosphorylationofSTATprotein
Inhibitor of nuclear factor kappa-B kinase subunit alpha
3.2
76
74
IKKAIKKAO15111O15111anatomicalstructuremorphogenesiscellularresponsetocadmiumioncellularresponsetoreactiveoxygenspeciescellularresponsetotumornecrosisfactorcellularresponsetovirusI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationimmuneresponseinflammatoryresponseinnateimmuneresponsenegativeregulationofNF-kappaBtranscriptionfactoractivityNIK/NF-kappaBsignalingpeptidyl-serinephosphorylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationresponsetovirustumornecrosisfactor-mediatedsignalingpathway
Myelin P2 protein
3.2
64
76
MYP2MYP2P02689P02689fattyacidtransportmembraneorganization
Methionine-R-sulfoxide reductase B2, mitochondrial
3.1
49
89
MSRB2MSRB2Q78J03Q78J03actinfilamentpolymerizationproteinrepairresponsetooxidativestress
Branched-chain-amino-acid aminotransferase, mitochondrial
3.2
79
73
✔
BCAT2BCAT2O15382O15382branched-chainaminoacidbiosyntheticprocesscellularresponsetoleukemiainhibitoryfactorisoleucinecatabolicprocessleucinebiosyntheticprocesslipidmetabolicprocessregulationofhormonelevelsvalinebiosyntheticprocess
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
3.2
58
81
A0A4X1VYV0A0A4X1VYV0A0A4X1VYV0A0A4X1VYV0
Alkylated DNA repair protein alkB homolog 8
3.2
52
88
ALKB8ALKB8Q96BT7Q96BT7cellularresponsetoDNAdamagestimulustRNAmethylationtRNAwobbleuridinemodification
RNA-binding protein 10
3.2
45
91
RBM10RBM10P98175P98175"3-UTR-mediatedmRNAstabilization"mRNAsplicingviaspliceosomenegativeregulationofmRNAsplicingviaspliceosomenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofvascularassociatedsmoothmusclecellapoptoticprocessvascularassociatedsmoothmusclecellapoptoticprocessvascularassociatedsmoothmusclecellproliferation
Chloride intracellular channel protein 3
3.2
80
75
✔
CLIC3CLIC3O95833O95833chloridetransportregulationofiontransmembranetransportsignaltransduction
Ubiquitin carboxyl-terminal hydrolase 21
3.3
46
91
UBP21UBP21Q9UK80Q9UK80chromatinorganizationhistonedeubiquitinationpositiveregulationofDNA-templatedtranscriptionproteindeubiquitinationubiquitin-dependentproteincatabolicprocess
Histone-lysine N-methyltransferase SUV39H2
3.8
58
92
SUV92SUV92Q9H5I1Q9H5I1cellcyclecelldifferentiationcellularresponsetohypoxiachromatinorganizationchromatinremodelinghistoneH3-K9dimethylationhistoneH3-K9trimethylationhistonelysinemethylationnegativeregulationofcircadianrhythmnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIrhythmicprocess
Mothers against decapentaplegic homolog 5
3.2
70
79
SMAD5SMAD5P97454P97454anatomicalstructuremorphogenesisangiogenesisBMPsignalingpathwaybonedevelopmentcardiacmusclecontractioncartilagedevelopmentcelldifferentiationcellularresponsetoBMPstimuluscellularresponsetoorganiccycliccompoundembryonicpatternspecificationerythrocytedifferentiationgermcelldevelopmentMullerianductregressionnegativeregulationofapoptoticprocessnegativeregulationofFassignalingpathwaynegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastfatecommitmentpositiveregulationofosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimulusproteinphosphorylationSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopment
DNA damage-binding protein 1
3.2
89
70
DDB1DDB1Q16531Q16531apoptoticprocessbiologicalprocessinvolvedininteractionwithsymbiontcellularresponsetoDNAdamagestimuluscellularresponsetoUVDNArepairectopicgermcellprogrammedcelldeathhistoneH2Amonoubiquitinationnegativeregulationofapoptoticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofreproductiveprocessnucleotide-excisionrepairpositiveregulationbyvirusofviralproteinlevelsinhostcellpositiveregulationofgluconeogenesispositiveregulationofproteincatabolicprocesspositiveregulationofviralgenomereplicationproteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofcircadianrhythmregulationofmitoticcellcyclephasetransitionrhythmicprocessubiquitin-dependentproteincatabolicprocessUV-damageexcisionrepairviralreleasefromhostcellWntsignalingpathway
P-type Cu(+) transporter
3.2
39
77
B7ZLR3B7ZLR3B7ZLR3B7ZLR3regulationofbiologicalquality
Mucolipin-2
3.2
50
80
MCLN2MCLN2Q8IZK6Q8IZK6adaptiveimmuneresponsecalciumiontransmembranetransportinnateimmuneresponsemacrophagemigrationneutrophilmigrationpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofmacrophageinflammatoryprotein1alphaproductionpositiveregulationofmonocytechemotacticprotein-1productionproteintransport
DNA polymerase delta catalytic subunit
3.2
50
88
✔
DPOD1DPOD1P28340P28340base-excisionrepairgap-fillingcellularresponsetoUVDNAbiosyntheticprocessDNArepairDNAreplicationDNAreplicationproofreadingDNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationerror-freetranslesionsynthesisfattyacidhomeostasisnucleotide-excisionrepairDNAgapfillingresponsetoUV
Replication protein A 70 kDa DNA-binding subunit
3.4
46
91
✔
RFA1RFA1P27694P27694base-excisionrepaircellularresponsetoDNAdamagestimulusDNArecombinationDNArepairDNAreplicationDNAunwindinginvolvedinDNAreplicationDNA-templatedDNAreplicationdouble-strandbreakrepairviahomologousrecombinationmeioticcellcyclemismatchrepairnucleotide-excisionrepairproteinlocalizationtochromosometelomeremaintenancetelomeremaintenanceviatelomerase
Ran-binding protein 10
3.2
84
71
RBP10RBP10Q6VN19Q6VN19cellsurfacereceptorsignalingpathwaycytoskeletonorganizationmicrotubulecytoskeletonorganization
Serine/threonine-protein kinase B-raf
3.5
53
93
BRAFBRAFP15056P15056animalorganmorphogenesisCD4-positiveorCD8-positivealpha-betaTcelllineagecommitmentCD4-positivealpha-betaTcelldifferentiationcellularresponsetocalciumioncellularresponsetoxenobioticstimulusendothelialcellapoptoticprocessepidermalgrowthfactorreceptorsignalingpathwayERK1andERK2cascadeestablishmentofproteinlocalizationtomembranefacedevelopmentheadmorphogenesislong-termsynapticpotentiationMAPKcascademyeloidprogenitorcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofendothelialcellapoptoticprocessnegativeregulationoffibroblastmigrationnegativeregulationofneuronapoptoticprocessnegativeregulationofsynapticvesicleexocytosispositiveregulationofaxonregenerationpositiveregulationofaxonogenesispositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofglucosetransmembranetransportpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingproteinphosphorylationregulationofcellpopulationproliferationregulationofTcelldifferentiationsomaticstemcellpopulationmaintenancestressfiberassemblysubstrateadhesion-dependentcellspreadingsynapticvesicleexocytosisTcelldifferentiationinthymusTcellreceptorsignalingpathwaythymusdevelopmentthyroidglanddevelopmenttrehalosemetabolisminresponsetostressvisuallearning
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
3.2
75
77
SAMH1SAMH1Q9Y3Z3Q9Y3Z3cellularresponsetoDNAdamagestimulusdATPcatabolicprocessdefenseresponsetovirusdeoxyribonucleotidecatabolicprocessdGTPcatabolicprocessDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairviahomologousrecombinationimmuneresponseinnateimmuneresponsenegativeregulationoftypeIinterferon-mediatedsignalingpathwayproteinhomotetramerizationregulationofinnateimmuneresponsesomatichypermutationofimmunoglobulingenes
Nuclease EXOG, mitochondrial
3.2
61
78
EXOGEXOGQ9Y2C4Q9Y2C4apoptoticDNAfragmentation
Tyrosine-protein kinase ITK/TSK
3.6
45
86
ITKITKQ08881Q08881activationofphospholipaseCactivityadaptiveimmuneresponseBcellreceptorsignalingpathwaycellulardefenseresponsegamma-deltaTcellactivationintracellularsignaltransductionNKTcelldifferentiationpositiveregulationofcytokineproductionsignaltransductionTcellactivationTcellreceptorsignalingpathway
MORC family CW-type zinc finger protein 3
3.6
55
88
✔
MORC3MORC3F7BJB9F7BJB9innateimmuneresponsemaintenanceofproteinlocationinnucleusnegativeregulationoffibroblastproliferationpeptidyl-serinephosphorylationpositiveregulationofcellularsenescencepost-embryonicdevelopmentproteinphosphorylationproteinstabilization
Zinc finger MYND-type containing 8
3.2
52
87
Q5TH12Q5TH12Q5TH12Q5TH12
C-1-tetrahydrofolate synthase, cytoplasmic
3.2
96
67
C1TCC1TCP11586P1158610-formyltetrahydrofolatebiosyntheticprocessembryonicneurocraniummorphogenesisembryonicviscerocraniummorphogenesisheartdevelopmenthistidinebiosyntheticprocessmethioninebiosyntheticprocessmethioninemetabolicprocessneuraltubeclosureneutrophilhomeostasisone-carbonmetabolicprocesspurinenucleotidebiosyntheticprocesspurineribonucleotidebiosyntheticprocessserinefamilyaminoacidbiosyntheticprocessserinefamilyaminoacidmetabolicprocesssomitedevelopmenttetrahydrofolateinterconversiontranssulfuration
Caspase-4
4.2
54
75
CASP4CASP4P70343P70343actinfilamentorganizationdefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumectopicgermcellprogrammedcelldeathinflammatoryresponseinnateimmuneresponsepositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-18-mediatedsignalingpathwaypositiveregulationofmacrophagecytokineproductionproteinautoprocessingpyroptosisregulationofapoptoticprocessregulationofinflammatoryresponse
Low affinity immunoglobulin epsilon Fc receptor
3.0
30
90
FCER2FCER2P06734P06734positiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofnitric-oxidesynthasebiosyntheticprocesssequesteringofmetalion
All-trans-retinol dehydrogenase [NAD(+)] ADH7
3.4
68
91
ADH7ADH7P40394P40394ethanoloxidationfattyacidomega-oxidationresponsetobacteriumresponsetoethanolretinoicacidmetabolicprocessretinoidmetabolicprocessretinolmetabolicprocess
DNA repair protein complementing XP-A cells
3.9
40
89
XPAXPAP23025P23025base-excisionrepairDNArepairnucleotide-excisionrepairinvolvedininterstrandcross-linkrepairnucleotide-excisionrepairDNAdamagerecognitionnucleotide-excisionrepairDNAincisionproteinlocalizationtonucleusUVprotectionUV-damageexcisionrepair
Cryptochrome-1
3.3
74
88
CRY1PER2P97784O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodgluconeogenesisglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofDNA-templatedtranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofgluconeogenesisnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgluconeogenesispositiveregulationofproteinubiquitinationregulationofcircadianrhythmregulationofDNAdamagecheckpointregulationofgluconeogenesisresponsetoactivityresponsetoglucagonresponsetoinsulinresponsetolightstimulusselectiveautophagysignaltransductioninresponsetoDNAdamagecircadianregulationoftranslationfattyacidmetabolicprocessglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationoffatcellproliferationnegativeregulationofterminationofDNA-templatedtranscriptionnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
E3 ubiquitin-protein ligase XIAP
3.4
57
94
XIAPXIAPP98170P98170cellularresponsetoDNAdamagestimuluscopperionhomeostasisinhibitionofcysteine-typeendopeptidaseactivityinhibitionofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwayneuronapoptoticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofJNKcascadepositiveregulationofproteinlinearpolyubiquitinationpositiveregulationofproteinubiquitinationregulationofapoptosisinvolvedintissuehomeostasisregulationofapoptoticprocessregulationofBMPsignalingpathwayregulationofcellcycleregulationofcellpopulationproliferationregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayWntsignalingpathway
Histone deacetylase 8
3.2
79
73
HDAC8HDAC8Q9BY41Q9BY41chromatinorganizationhistonedeacetylationmitoticsisterchromatidcohesionnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofproteinstabilityregulationoftelomeremaintenanceregulationoftranscriptionbyRNApolymeraseII
GTP cyclohydrolase 1
3.2
72
79
GCH1GCH1P22288P22288"78-dihydroneopterin3-triphosphatebiosyntheticprocess"dihydrobiopterinmetabolicprocessdopaminebiosyntheticprocessnegativeregulationofbloodpressureneuromuscularprocesscontrollingposturepositiveregulationofheartratepositiveregulationofnitric-oxidesynthaseactivityprotein-containingcomplexassemblypteridine-containingcompoundbiosyntheticprocessregulationofbloodpressureregulationoflungbloodpressureregulationofremovalofsuperoxideradicalsresponsetolipopolysaccharideresponsetopainresponsetotumornecrosisfactorresponsetotypeIIinterferontetrahydrobiopterinbiosyntheticprocesstetrahydrofolatebiosyntheticprocessvasodilation
E3 ubiquitin-protein ligase RNF146
3.2
55
92
RN146RN146Q9NTX7Q9NTX7positiveregulationofcanonicalWntsignalingpathwayproteinautoubiquitinationproteinK48-linkedubiquitinationubiquitin-dependentproteincatabolicprocessWntsignalingpathway
Metallothionein-3
4.0
50
92
MT3MT3P25713P25713activationofproteinkinaseBactivityastrocytedevelopmentbraindevelopmentcellularlipidcatabolicprocesscellularmetalionhomeostasiscellularresponsetocadmiumioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetooxidativestresscellularresponsetoreactiveoxygenspeciescellularresponsetozincioncellularzincionhomeostasischolesterolcatabolicprocessdetoxificationofcopperionenergyreservemetabolicprocessERK1andERK2cascadehistonemodificationleptin-mediatedsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofaxonextensionnegativeregulationofcellgrowthnegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofhydrogenperoxidecatabolicprocessnegativeregulationofnecroticcelldeathnegativeregulationofneuronapoptoticprocessnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoxidoreductaseactivitynegativeregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofcatalyticactivitypositiveregulationofcelldeathpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationoflysosomalmembranepermeabilitypositiveregulationofnecroticcelldeathpositiveregulationofoxygenmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayproteinkinaseBsignalingproteinstabilizationregulationofproteinglycosylationregulationofresponsetofoodremovalofsuperoxideradicalsresponsetohypoxiazinciontransport
Alcohol dehydrogenase class-3
3.4
45
92
ADHXADHXP11766P11766ethanoloxidationfattyacidomega-oxidationformaldehydecatabolicprocesspeptidyl-cysteineS-nitrosylationpositiveregulationofbloodpressurerespiratorysystemprocessresponsetolipopolysaccharideresponsetonitrosativestressresponsetoredoxstateretinoidmetabolicprocess
Histone-lysine N-methyltransferase 2B
3.4
49
92
KMT2BKMT2BQ9UMN6Q9UMN6chromatinorganizationhistoneH3-K4dimethylationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationofDNA-templatedtranscription
Retinol-binding protein 4
2.0
51
84
RET4RET4P27485P27485retinoltransport
Chromodomain-helicase-DNA-binding protein 5
3.4
53
87
CHD5CHD5Q8TDI0Q8TDI0cerebralcortexneurondifferentiationchromatinremodelinghistoneH3-K27trimethylationhistoneH4acetylationnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionbyRNApolymeraseIIspermDNAcondensation
Protein-tyrosine kinase 2-beta
3.2
50
85
FAK2FAK2Q14289Q14289activationofGTPaseactivityactivationofJanuskinaseactivityadaptiveimmuneresponseapoptoticprocessbloodvesselendothelialcellmigrationboneresorptioncelldifferentiationcellsurfacereceptorsignalingpathwaycellulardefenseresponsecellularresponsetofluidshearstresscellularresponsetoretinoicacidchemokine-mediatedsignalingpathwayendothelinreceptorsignalingpathwayepidermalgrowthfactorreceptorsignalingpathwayfocaladhesionassemblyglialcellproliferationinnateimmuneresponseintegrin-mediatedsignalingpathwayionotropicglutamatereceptorsignalingpathwaylong-termsynapticdepressionlong-termsynapticpotentiationMAPKcascademarginalzoneBcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofbonemineralizationnegativeregulationofcellpopulationproliferationnegativeregulationofmusclecellapoptoticprocessnegativeregulationofmyeloidcelldifferentiationnegativeregulationofneuronapoptoticprocessnegativeregulationofpotassiumiontransportneuronprojectiondevelopmentoocytematurationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofangiogenesispositiveregulationofBcellchemotaxispositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofendothelialcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteinkinaseactivitypositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftranslationpositiveregulationofubiquitin-dependentproteincatabolicprocesspostsynapticmodulationofchemicalsynaptictransmissionproteinautophosphorylationproteinphosphorylationprotein-containingcomplexassemblyregulationofactincytoskeletonreorganizationregulationofcalcium-mediatedsignalingregulationofcelladhesionregulationofcellshaperegulationofcGMP-mediatedsignalingregulationofestablishmentofcellpolarityregulationofinositoltrisphosphatebiosyntheticprocessregulationofmacrophagechemotaxisregulationofNMDAreceptoractivityregulationofpostsynapticdensityassemblyregulationofreleaseofsequesteredcalciumionintocytosolregulationofsynapticplasticityregulationofubiquitin-dependentproteincatabolicprocessresponsetocalciumionresponsetocAMPresponsetocationstressresponsetococaineresponsetoethanolresponsetoglucoseresponsetohormoneresponsetohydrogenperoxideresponsetohypoxiaresponsetoimmobilizationstressresponsetoischemiaresponsetolithiumionresponsetomechanicalstimulusresponsetoxenobioticstimulussignalcomplexassemblysignaltransductionsproutingangiogenesisstressfiberassemblytransmembranereceptorproteintyrosinekinasesignalingpathwaytumornecrosisfactor-mediatedsignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
Inositol-pentakisphosphate 2-kinase
4.0
69
81
IPPKIPPKQ6P1C1Q6P1C1inositolphosphatebiosyntheticprocessinositolphosphorylationpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseI
Transcription initiation factor IIB
3.8
49
89
TF2BTF2BQ00403Q00403DNA-templatedtranscriptioninitiationmeioticsisterchromatidcohesionpositiveregulationofcorepromoterbindingproteinacetylationRNApolymeraseIIcorecomplexassemblyRNApolymeraseIIpreinitiationcomplexassemblyspindleassemblytranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromotertranscriptionalstartsiteselectionatRNApolymeraseIIpromoterviraltranscription
XIAP-associated factor 1
3.2
32
90
XAF1XAF1Q6GPH4Q6GPH4apoptoticprocessresponsetointerferon-beta
Nuclear factor 1 X-type
3.3
65
92
NFIXNFIXQ14938Q14938DNAreplicationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
NAD-dependent protein deacylase sirtuin-6
3.3
47
90
SIR6SIR6Q8N6T7Q8N6T7base-excisionrepaircardiacmusclecelldifferentiationcircadianregulationofgeneexpressiondeterminationofadultlifespandouble-strandbreakrepairglucosehomeostasishistoneH3deacetylationketonebiosyntheticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofcellularsenescencenegativeregulationofgeneexpressionepigeneticnegativeregulationofgluconeogenesisnegativeregulationofglucoseimportnegativeregulationofglycolyticprocessnegativeregulationofproteinimportintonucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionelongationbyRNApolymeraseIInegativeregulationoftranspositionpericentricheterochromatinformationpositiveregulationofbloodvesselbranchingpositiveregulationofchondrocyteproliferationpositiveregulationofcold-inducedthermogenesispositiveregulationofdouble-strandbreakrepairpositiveregulationoffatcelldifferentiationpositiveregulationoffibroblastproliferationpositiveregulationofinsulinsecretionpositiveregulationofproteinexportfromnucleuspositiveregulationofproteinlocalizationtochromatinpositiveregulationofstemcelldifferentiationpositiveregulationofstemcellproliferationpositiveregulationoftelomeremaintenancepositiveregulationoftranscriptionfactorcatabolicprocesspositiveregulationofvascularendothelialcellproliferationproteindeacetylationproteindelipidationproteindestabilizationregulationofcircadianrhythmregulationofdouble-strandbreakrepairviahomologousrecombinationregulationoflipidcatabolicprocessregulationoflipidmetabolicprocessresponsetoUVsubtelomericheterochromatinformation
Myosin-7
3.3
52
83
MYH7MYH7P12883P12883adultheartdevelopmentATPmetabolicprocesscardiacmusclecontractioncardiacmusclehypertrophyinresponsetostressmusclecontractionmusclefilamentslidingregulationofheartrateregulationofslow-twitchskeletalmusclefibercontractionregulationoftheforceofheartcontractionregulationoftheforceofskeletalmusclecontractionsarcomereorganizationskeletalmusclecontractionstriatedmusclecontractiontransitionbetweenfastandslowfiberventricularcardiacmuscletissuemorphogenesis
E3 ubiquitin-protein ligase SIAH1
3.6
48
88
SIAH1SIAH1Q8IUQ4Q8IUQ4amyloidfibrilformationanatomicalstructuremorphogenesisapoptoticprocessaxonguidancecanonicalWntsignalingpathwaycellcyclenervoussystemdevelopmentneuronapoptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofintrinsicapoptoticsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteincatabolicprocessspermatogenesisubiquitin-dependentproteincatabolicprocess
Mitogen-activated protein kinase kinase kinase 7
3.3
65
73
M3K7M3K7O43318O43318activationofNF-kappaB-inducingkinaseactivityanoikiscytosolicpatternrecognitionreceptorsignalingpathwayFc-epsilonreceptorsignalingpathwayhistoneH3acetylationI-kappaBkinase/NF-kappaBsignalingI-kappaBphosphorylationinterleukin-1-mediatedsignalingpathwayJNKcascadeMAPKcascadeMyD88-dependenttoll-likereceptorsignalingpathwaynucleotide-bindingoligomerizationdomaincontainingsignalingpathwayp38MAPKcascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofJUNkinaseactivitypositiveregulationofmacroautophagypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellcytokineproductionstimulatoryC-typelectinreceptorsignalingpathwaystress-activatedMAPKcascadeTcellreceptorsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathway
Pre-mRNA-splicing factor RBM22
3.6
47
96
RBM22RBM22Q9NW64Q9NW64cellularresponsetoxenobioticstimulusmRNAcissplicingviaspliceosomemRNAsplicingviaspliceosomepositiveregulationofproteinexportfromnucleuspositiveregulationofproteinimportintonucleuspositiveregulationofRNAsplicing
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
3.5
46
85
AT2A1AT2A1P04191P04191calciumionimportintosarcoplasmicreticulumcalciumiontransportnegativeregulationofstriatedmusclecontractionpositiveregulationofATPase-coupledcalciumtransmembranetransporteractivitypositiveregulationofcalciumionimportintosarcoplasmicreticulumpositiveregulationofcardiacmusclecellcontractionpositiveregulationoffast-twitchskeletalmusclefibercontractionregulationofstriatedmusclecontraction
DNA-directed RNA polymerase II subunit RPB3
3.3
48
91
RPB3RPB3P19387P19387transcriptionbyRNApolymeraseII
cGMP-specific 3',5'-cyclic phosphodiesterase
3.3
48
79
PDE5APDE5AO76074O76074cGMPcatabolicprocessnegativeregulationofcardiacmusclecontractionnegativeregulationofTcellproliferationoocytedevelopmentpositiveregulationofcardiacmusclehypertrophypositiveregulationofMAPkinaseactivitypositiveregulationofoocytedevelopmentregulationofnitricoxidemediatedsignaltransductionrelaxationofcardiacmusclesignaltransductionTcellproliferation
DNA dC->dU-editing enzyme APOBEC-3F
3.3
70
84
ABC3FABC3FQ8IUX4Q8IUX4baseconversionorsubstitutioneditingcytidinetouridineeditingdefenseresponsetovirusDNAcytosinedeaminationDNAdemethylationinnateimmuneresponsenegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftranspositionnegativeregulationofviralgenomereplicationnegativeregulationofviralprocesspositiveregulationofdefenseresponsetovirusbyhost
Transcriptional repressor CTCF
3.5
55
98
CTCFCTCFP49711P49711chromatinloopingchromosomesegregationDNAmethylationepigeneticregulationofgeneexpressiongenomicimprintingmaintenanceofDNAmethylationnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionproteinlocalizationtochromosomecentromericregionregulationofcentromericsisterchromatidcohesionregulationofgeneexpressionbygenomicimprintingregulationoftranscriptionbyRNApolymeraseII
ATPase GET3
3.3
69
84
GET3GET3O43681O43681post-translationalproteintargetingtoendoplasmicreticulummembraneproteininsertionintoERmembranetail-anchoredmembraneproteininsertionintoERmembrane
Short transient receptor potential channel 3
3.7
27
88
TRPC3TRPC3Q13507Q13507calciumiontransmembranetransportcalciumiontransportphototransductionpositiveregulationofcalciumiontransportintocytosolpositiveregulationofcardiacmusclehypertrophyinresponsetostressregulationofcytosoliccalciumionconcentrationresponsetoATPresponsetocalciumionsinglefertilization
Dedicator of cytokinesis protein 2
3.3
74
71
DOCK2DOCK2Q92608Q92608actincytoskeletonorganizationalpha-betaTcellproliferationcellmigrationchemotaxisestablishmentofTcellpolarityimmunologicalsynapseformationmacropinocytosismembraneraftpolarizationmyeloiddendriticcellactivationinvolvedinimmuneresponsemyoblastfusionnegativethymicTcellselectionpositiveregulationofphagocytosispositivethymicTcellselectionregulationofsmallGTPasemediatedsignaltransductionsmallGTPasemediatedsignaltransduction
Iron-sulfur cluster assembly enzyme ISCU
3.9
53
81
ISCUISCUQ9D7P6Q9D7P62Fe-2Sclusterassembly4Fe-4Sclusterassemblycellularironionhomeostasisironionhomeostasisiron-sulfurclusterassemblynegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
DNA-(apurinic or apyrimidinic site) lyase
3.8
51
88
F7AMK3F7AMK3F7AMK3F7AMK3base-excisionrepair
PHD finger-like domain-containing protein 5A
3.6
51
84
PHF5APHF5AQ7RTV0Q7RTV0mRNAsplicingviaspliceosomepositiveregulationofDNA-templatedtranscriptionstemcelldifferentiationU2-typeprespliceosomeassembly
Four and a half LIM domains protein 1
3.3
46
92
FHL1FHL1Q13642Q13642animalorganmorphogenesiscelldifferentiationmuscleorgandevelopmentnegativeregulationofcellgrowthnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofpotassiumiontransportregulationofmembranedepolarizationregulationofpotassiumiontransmembranetransporteractivity
Rho guanine nucleotide exchange factor 7
3.3
53
76
ARHG7ARHG7Q14155Q14155ephrinreceptorsignalingpathwayfocaladhesionassemblyGolgiorganizationintracellularsignaltransductionlamellipodiumassemblynegativeregulationofmicrotubulenucleationnervoussystemdevelopmentpositiveregulationofapoptoticprocesspositiveregulationoffibroblastmigrationpositiveregulationofGTPaseactivitypositiveregulationoflamellipodiummorphogenesispositiveregulationofsubstrateadhesion-dependentcellspreadingregulationofGTPbindingsignaltransduction
Major histocompatibility complex class I-related gene protein
3.3
69
76
HMR1HMR1Q95460Q95460antigenprocessingandpresentationofexogenousantigenantigenprocessingandpresentationofpeptideantigenviaMHCclassIdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumimmuneresponseinnateimmuneresponsepositiveregulationofTcellmediatedcytotoxicitydirectedagainsttumorcelltargetTcelldifferentiationinthymus
Mitogen-activated protein kinase kinase kinase 8
3.3
66
78
M3K8M3K8P41279P41279cellcycleMAPKcascadeproteinphosphorylationTcellcostimulation
MOB kinase activator 1A
3.3
59
87
MOB1AMOB1AQ9H8S9Q9H8S9hipposignalingpositiveregulationofproteinphosphorylationsignaltransduction
Ubiquitin-conjugating enzyme E2 E1
3.4
66
82
UB2E1UB2E1P51965P51965histoneH2BubiquitinationhistonemonoubiquitinationISG15-proteinconjugationproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
Tyrosine-protein kinase JAK1
3.3
52
82
✔
JAK1JAK1P23458P23458celldifferentiationcellularresponsetoviruscytokine-mediatedsignalingpathwaygrowthhormonereceptorsignalingpathwayviaJAK-STATinterleukin-2-mediatedsignalingpathwayinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionpositiveregulationofhomotypiccell-celladhesionpositiveregulationofsproutingangiogenesisproteinlocalizationtocell-celljunctionproteinphosphorylationreceptorsignalingpathwayviaJAK-STATresponsetoantibiotictypeIinterferon-mediatedsignalingpathwaytypeIIinterferon-mediatedsignalingpathwaytypeIIIinterferon-mediatedsignalingpathwaytyrosinephosphorylationofSTATprotein
Calcium/calmodulin-dependent protein kinase type 1
3.3
89
74
KCC1AKCC1AQ63450Q63450cellcyclecelldifferentiationnegativeregulationofproteinbindingnervoussystemdevelopmentnucleocytoplasmictransportpeptidyl-serinephosphorylationpositiveregulationofdendriticspinedevelopmentpositiveregulationofmusclecelldifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinacetylationpositiveregulationofproteinexportfromnucleuspositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofsynapsestructuralplasticitypositiveregulationofsyncytiumformationbyplasmamembranefusionpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofmusclecelldifferentiationregulationofproteinbindingregulationofproteinlocalizationregulationofsynapseorganizationsignaltransduction
mRNA cap guanine-N7 methyltransferase
4.1
76
77
MCESMCESO43148O431487-methylguanosinemRNAcappingcellularresponsetoleukemiainhibitoryfactor
Tyrosine-protein kinase Tec
3.3
45
81
TECTECP42680P42680adaptiveimmuneresponseBcellreceptorsignalingpathwayintegrin-mediatedsignalingpathwayintracellularsignaltransductionproteinphosphorylationregulationofplateletactivationTcellreceptorsignalingpathwaytissueregeneration
Lysine-specific demethylase 7A
3.4
50
91
KDM7AKDM7AQ6ZMT4Q6ZMT4chromatinorganizationmidbraindevelopmentpositiveregulationofDNA-templatedtranscriptionproteindemethylationregulationoftranscriptionbyRNApolymeraseII
Rhombotin-2
3.7
54
86
RBTN2RBTN2P25791P25791cellularresponsetothyroidhormonestimuluspositiveregulationoftranscriptionbyRNApolymeraseII
SWI/SNF complex subunit SMARCC1
3.3
56
75
SMRC1SMRC1Q92922Q92922animalorganmorphogenesischromatinremodelinginsulinreceptorsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnervoussystemdevelopmentnucleosomedisassemblypositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
Cytidine deaminase
3.6
74
78
CDDCDDP32320P32320cellsurfacereceptorsignalingpathwaycellularresponsetoexternalbioticstimuluscytidinedeaminationcytosinemetabolicprocessnegativeregulationofcellgrowthnegativeregulationofnucleotidemetabolicprocesspyrimidine-containingcompoundsalvageresponsetocycloheximideUMPsalvage
DNA topoisomerase 2-binding protein 1
2.0
54
86
TOPB1PHF8Q92547Q9UPP1cellularresponsetoDNAdamagestimulusDNAmetabolicprocessDNArepairDNAreplicationinitiationhomologousrecombinationmitoticDNAreplicationcheckpointsignalingmitoticG2DNAdamagecheckpointsignalingresponsetoionizingradiationbraindevelopmentchromatinorganizationG1/StransitionofmitoticcellcyclenegativeregulationofrDNAheterochromatinformationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIproteindemethylationregulationoftranscriptionbyRNApolymeraseII
DNA dC->dU-editing enzyme APOBEC-3G
3.3
68
88
M1GSK9M1GSK9M1GSK9M1GSK9defenseresponsetovirusDNAcytosinedeaminationinnateimmuneresponsenegativeregulationoftransposition
Methylcytosine dioxygenase TET1
3.3
40
79
TET1TET1Q8NFU7Q8NFU75-methylcytosinecatabolicprocesschromatinorganizationDNAdemethylationinnercellmasscelldifferentiationnegativeregulationofcellmigrationnegativeregulationofDNAmethylation-dependentheterochromatinformationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayoxidativedemethylationpositiveregulationofcellpopulationproliferationpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIproteinO-linkedglycosylationstemcellpopulationmaintenance
Mevalonate kinase
3.3
60
80
KIMEKIMEQ03426Q03426cholesterolbiosyntheticprocessisopentenyldiphosphatebiosyntheticprocessmevalonatepathwayisoprenoidbiosyntheticprocessnegativeregulationofinflammatoryresponsephosphorylation
Histone acetyltransferase KAT6A
3.4
58
98
KAT6AKAT6AQ92794Q92794cellularsenescencechromosomeorganizationhistoneH3acetylationmyeloidcelldifferentiationnegativeregulationofDNA-templatedtranscriptionnucleosomeassemblypositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIproteinacetylationregulationofdevelopmentalprocessregulationofDNA-templatedtranscriptionregulationofhemopoiesisregulationofsignaltransductionbyp53classmediator
CXXC-type zinc finger protein 1
3.6
52
89
CXXC1CXXC1Q9P0U4Q9P0U4histoneH3-K4methylationpositiveregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscription
DNA helicase MCM8
3.4
59
89
MCM8MCM8Q9UJA3Q9UJA3cellcyclecellularresponsetoDNAdamagestimulusDNAduplexunwindingdouble-strandbreakrepairviahomologousrecombinationfemalegametegenerationmalegametegenerationmismatchrepairinvolvedinmaintenanceoffidelityinvolvedinDNA-dependentDNAreplicationproteinlocalizationtochromatinproteinstabilizationrecombinationalinterstrandcross-linkrepair
Spermine synthase
3.3
78
72
SPSYSPSYP52788P52788methioninemetabolicprocesspolyaminemetabolicprocesssperminebiosyntheticprocess
Immunoglobulin kappa light chain
3.3
86
71
IGKIGKP0DOX7P0DOX7adaptiveimmuneresponse
Baculoviral IAP repeat-containing protein 5
3.3
65
89
✔
BIRC5BIRC5O15392O15392celldivisionestablishmentofchromosomelocalizationG2/Mtransitionofmitoticcellcyclemitoticcellcyclemitoticcytokinesismitoticspindleassemblycheckpointsignalingmitoticspindlemidzoneassemblymitoticspindleorganizationnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofDNA-templatedtranscriptionpositiveregulationofattachmentofmitoticspindlemicrotubulestokinetochorepositiveregulationofcellpopulationproliferationpositiveregulationofexitfrommitosispositiveregulationofmitoticcellcyclepositiveregulationofmitoticcellcyclespindleassemblycheckpointpositiveregulationofmitoticcytokinesispositiveregulationofmitoticsisterchromatidseparationpositiveregulationofproteinphosphorylationproteinphosphorylationprotein-containingcomplexlocalizationregulationofcellcyclesensoryperceptionofsound
Ubiquitin-40S ribosomal protein S27a
3.5
53
99
RS27ARS27AP62979P62979cytoplasmictranslationmodification-dependentproteincatabolicprocessproteinubiquitinationtranslation
Eukaryotic translation initiation factor 5B
3.3
71
77
IF2PIF2PO60841O60841regulationoftranslationalinitiationtranslationalinitiation
Cell division cycle protein 23 homolog
3.3
76
68
CDC23CDC23Q9UJX2Q9UJX2anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionmetaphase/anaphasetransitionofmitoticcellcyclemitoticcellcyclemitoticmetaphaseplatecongressionpositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationproteinubiquitinationregulationofexitfrommitosisregulationofmeioticcellcycleregulationofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionubiquitin-dependentproteincatabolicprocess
Hemoglobin subunit beta
3.3
87
66
HBBHBBP68871P68871bloodvesseldiametermaintenancecarbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportplateletaggregationpositiveregulationofcelldeathpositiveregulationofnitricoxidebiosyntheticprocessregulationofbloodpressurerenalabsorptionresponsetohydrogenperoxide
Ubiquitin carboxyl-terminal hydrolase 15
3.3
44
90
UBP15UBP15Q9Y4E8Q9Y4E8BMPsignalingpathwayhistoneH2BconservedC-terminallysinedeubiquitinationmonoubiquitinatedproteindeubiquitinationnegativeregulationofantifungalinnateimmuneresponsepathway-restrictedSMADproteinphosphorylationpositiveregulationofRIG-IsignalingpathwayproteindeubiquitinationproteinK27-linkeddeubiquitinationregulationofintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressbyp53classmediatortransforminggrowthfactorbetareceptorsignalingpathwayubiquitin-dependentproteincatabolicprocess
Erythroid transcription factor
3.3
60
91
GATA1GATA1P17679P17679animalorganregenerationbasophildifferentiationbonemineralizationcelldevelopmentcellfatecommitmentcellpopulationproliferationcell-cellsignalingcellularresponsetocAMPcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetolipopolysaccharidecellularresponsetothyroidhormonestimulusdendriticcelldifferentiationembryonichemopoiesiseosinophilfatecommitmenterythrocytedevelopmenterythrocytedifferentiationhomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentmalegonaddevelopmentmegakaryocytedifferentiationmyeloidcellapoptoticprocessmyeloidcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofbonemineralizationnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofmyeloidcellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionregulatoryregionDNAbindingosteoblastproliferationplateletaggregationplateletformationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoferythrocytedifferentiationpositiveregulationofmastcelldegranulationpositiveregulationofosteoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIprimitiveerythrocytedifferentiationregulationofdefinitiveerythrocytedifferentiationregulationofglycoproteinbiosyntheticprocessregulationofprimitiveerythrocytedifferentiationSertolicelldevelopmenttranscriptionbyRNApolymeraseII
LIM and senescent cell antigen-like-containing domain protein 1
3.9
54
94
LIMS1LIMS1P48059P48059cell-celladhesioncell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimulusestablishmentofproteinlocalizationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofcell-substrateadhesionpositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofsubstrateadhesion-dependentcellspreadingtumornecrosisfactor-mediatedsignalingpathway
Prestin
3.3
72
75
D7PC76D7PC76D7PC76D7PC76regulationofcellshapesensoryperceptionofsound
DNA dC->dU-editing enzyme APOBEC-3C
3.3
64
72
ABC3CABC3CQ9NRW3Q9NRW3cytidinedeaminationcytidinetouridineeditingdefenseresponsetovirusDNAcytosinedeaminationDNAdemethylationinnateimmuneresponsenegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftranspositionnegativeregulationofviralgenomereplication
Nuclear receptor subfamily 4 group A member 1
3.9
40
89
NR4A1NR4A1P22736P22736apoptoticprocesscellmigrationinvolvedinsproutingangiogenesiscellularresponsetocorticotropin-releasinghormonestimuluscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetovascularendothelialgrowthfactorstimulusendothelialcellchemotaxisfatcelldifferentiationnegativeregulationofcellcyclenegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessneurotransmittersecretioninvolvedinregulationofskeletalmusclecontractionpositiveregulationofapoptoticprocesspositiveregulationofendothelialcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIregulationoftypeBpancreaticcellproliferationresponsetoamphetamineresponsetoelectricalstimulusresponsetolipopolysaccharidesignaltransductionskeletalmusclecelldifferentiationtranscriptionbyRNApolymeraseII
DNA damage-inducible transcript 4 protein
3.3
52
79
DDIT4DDIT4Q9NX09Q9NX09apoptoticprocessbraindevelopmentcellularresponsetodexamethasonestimulusdefenseresponsetovirusintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofglycolyticprocessnegativeregulationofintracellularsignaltransductionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofTORsignalingneurondifferentiationneuronmigrationneurotrophinTRKreceptorsignalingpathwaypositiveregulationofneurondeathprotein-containingcomplexdisassemblyreactiveoxygenspeciesmetabolicprocessregulationofTORsignalingresponsetohypoxia
STAM-binding protein
3.3
80
74
STABPSTABPO95630O95630hippocampalneuronapoptoticprocessmitoticcytokinesisnegativeregulationofhippocampalneuronapoptoticprocessnegativeregulationofphosphatidylinositol3-kinasesignalingnegativeregulationofRasproteinsignaltransductionpositiveregulationofcellpopulationproliferationproteindeubiquitinationproteinK63-linkeddeubiquitinationreceptorsignalingpathwayviaJAK-STAT
Protein BUD31 homolog
4.1
63
85
BUD31BUD31P41223P41223mRNAsplicingviaspliceosomepositiveregulationofandrogenreceptoractivity
NEDD4-like E3 ubiquitin-protein ligase WWP1
3.3
80
73
WWP1WWP1Q9H0M0Q9H0M0centralnervoussystemdevelopmentiontransmembranetransportnegativeregulationofDNA-templatedtranscriptionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationsignaltransductionviralentryintohostcell
E3 ubiquitin-protein ligase parkin
3.8
36
88
PRKNPRKNO60260O60260adultlocomotorybehavioraggresomeassemblyamyloidfibrilformationautophagyofmitochondrioncellularresponsetodopaminecellularresponsetomanganeseioncellularresponsetotoxicsubstancecellularresponsetounfoldedproteincentralnervoussystemdevelopmentdopaminemetabolicprocessdopamineuptakeinvolvedinsynaptictransmissionERADpathwayfreeubiquitinchainpolymerizationlearningmacroautophagymitochondrialfissionmitochondrionorganizationmitochondriontolysosometransportmitophagynegativeregulationbyhostofviralgenomereplicationnegativeregulationofactinfilamentbundleassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcelldeathnegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofendoplasmicreticulumstress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofexosomalsecretionnegativeregulationofgeneexpressionnegativeregulationofglucokinaseactivitynegativeregulationofinsulinsecretionnegativeregulationofintralumenalvesicleformationnegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofJNKcascadenegativeregulationofmitochondrialfusionnegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofoxidativestress-inducedcelldeathnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofprimaryamineoxidaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofspontaneousneurotransmittersecretionnegativeregulationoftranscriptionbyRNApolymeraseIIneuroncellularhomeostasisnorepinephrinemetabolicprocessparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofautophagyofmitochondrionpositiveregulationofdendriteextensionpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmitochondrialfissionpositiveregulationofmitochondrialfusionpositiveregulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofneurotransmitteruptakepositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteincatabolicprocesspositiveregulationofproteinlinearpolyubiquitinationpositiveregulationofproteinlocalizationtomembranepositiveregulationofretrogradetransportendosometoGolgipositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteincatabolicprocessproteindestabilizationproteindeubiquitinationproteinK11-linkedubiquitinationproteinK27-linkedubiquitinationproteinK29-linkedubiquitinationproteinK48-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinlocalizationtomitochondrionproteinmonoubiquitinationproteinpolyubiquitinationproteinstabilizationproteinubiquitinationregulationofapoptoticprocessregulationofautophagyregulationofcanonicalWntsignalingpathwayregulationofcellularresponsetooxidativestressregulationofdopaminemetabolicprocessregulationofdopaminesecretionregulationofglucosemetabolicprocessregulationoflipidtransportregulationofmitochondrialmembranepotentialregulationofmitochondrionorganizationregulationofproteinstabilityregulationofproteintargetingtomitochondrionregulationofproteinubiquitinationregulationofreactiveoxygenspeciesmetabolicprocessregulationofsynapticvesicleendocytosisregulationofsynapticvesicletransportregulationproteincatabolicprocessatpresynapseresponsetoendoplasmicreticulumstressresponsetooxidativestressstartleresponsesynaptictransmissionglutamatergicubiquitin-dependentproteincatabolicprocesszincionhomeostasis
DNA-directed RNA polymerase II subunit RPB2
3.6
69
90
RPB2RPB2P30876P30876transcriptionbyRNApolymeraseII
General transcription and DNA repair factor IIH helicase subunit XPB
3.3
61
77
ERCC3ERCC3P19447P19447apoptoticprocessDNArepairDNAtopologicalchangeembryonicorgandevelopmenthaircelldifferentiationnucleotide-excisionrepairnucleotide-excisionrepairDNAduplexunwindingpositiveregulationofapoptoticprocessproteinlocalizationregulationofmitoticcellcyclephasetransitionresponsetohypoxiaresponsetooxidativestressresponsetoUVtranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromotertranscriptioninitiationatRNApolymeraseIIpromotertranscription-couplednucleotide-excisionrepairUVprotection
Kinesin-like protein KIF11
3.3
77
78
KIF11KIF11P52732P52732celldivisionmicrotubule-basedmovementmitoticcellcyclemitoticcentrosomeseparationmitoticsisterchromatidsegregationmitoticspindleassemblymitoticspindleorganizationregulationofmitoticcentrosomeseparationspindleelongationspindleorganization
Breast cancer type 1 susceptibility protein
3.3
47
89
BRCA1BRCA1P38398P38398cellularresponsetoDNAdamagestimuluscellularresponsetoindole-3-methanolcellularresponsetoionizingradiationcellularresponsetotumornecrosisfactorcentrosomecyclechordateembryonicdevelopmentchromosomesegregationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdosagecompensationbyinactivationofXchromosomedouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationfattyacidbiosyntheticprocesshistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationhomologousrecombinationintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagelocalizationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointnegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcentriolereplicationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationoffattyacidbiosyntheticprocessnegativeregulationofhistoneacetylationnegativeregulationofhistoneH3-K4methylationnegativeregulationofhistoneH3-K9methylationnegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofangiogenesispositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofhistoneacetylationpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofhistoneH3-K9methylationpositiveregulationofhistoneH4-K16acetylationpositiveregulationofhistoneH4-K20methylationpositiveregulationofproteinubiquitinationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialgrowthfactorproductionpostreplicationrepairproteinautoubiquitinationproteinK6-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofcellcycleregulationofDNAdamagecheckpointregulationofDNAmethylationregulationofDNArepairregulationofgeneexpressionbygenomicimprintingregulationoftranscriptionbyRNApolymeraseIIresponsetoestrogenresponsetoionizingradiation
Solute carrier family 15 member 1
3.3
47
84
S15A1S15A1P46059P46059dipeptideimportacrossplasmamembraneiontransportproteintransporttransmembranetransporttripeptideimportacrossplasmamembrane
Tumor necrosis factor ligand superfamily member 13B
3.3
93
76
TN13BTN13BQ9Y275Q9Y275BcellcostimulationBcelldifferentiationBcellhomeostasisBcellproliferationgerminalcenterformationpositiveregulationofBcellproliferationpositiveregulationofgerminalcenterformationpositiveregulationofTcellproliferationsignaltransductionTcellcostimulationTcellproliferationtumornecrosisfactor-mediatedsignalingpathway
Protein disulfide-isomerase
2.0
68
86
✔
P4HA2PDIA1O15460P07237peptidyl-prolinehydroxylationto4-hydroxy-L-prolinecellularresponsetohypoxiacellularresponsetointerleukin-7endoplasmicreticulumtoGolgivesicle-mediatedtransportinsulinprocessinginterleukin-12-mediatedsignalingpathwayinterleukin-23-mediatedsignalingpathwaypositiveregulationofcelladhesionpositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofviralentryintohostcellproteinfoldingproteinfoldinginendoplasmicreticulumregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwayresponsetoendoplasmicreticulumstress
DNA helicase MCM9
3.4
57
93
MCM9MCM9Q9NXL9Q9NXL9cellularresponsetoDNAdamagestimulusDNAduplexunwindingdouble-strandbreakrepairviahomologousrecombinationfemalegametegenerationmismatchrepairinvolvedinmaintenanceoffidelityinvolvedinDNA-dependentDNAreplicationproteinlocalizationtochromatinrecombinationalinterstrandcross-linkrepair
Probable ATP-dependent RNA helicase DDX41
3.3
70
77
DDX41DDX41Q9UJV9Q9UJV9apoptoticprocesscelldifferentiationcellpopulationproliferationmRNAsplicingviaspliceosome
Mediator of DNA damage checkpoint protein 1
3.3
89
69
MDC1MDC1Q14676Q14676DNArepairmitoticintra-SDNAdamagecheckpointsignaling
NAD-dependent protein deacylase sirtuin-5, mitochondrial
3.6
41
91
SIR5SIR5Q9NXA8Q9NXA8mitochondrionorganizationnegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofreactiveoxygenspeciesmetabolicprocesspeptidyl-lysinedemalonylationpeptidyl-lysinedesuccinylationproteindeacetylationproteindeglutarylationproteindemalonylationproteindesuccinylationregulationofketonebiosyntheticprocessresponsetonutrientlevels
Mitofusin-1
3.3
64
74
MFN1MFN1Q8IWA4Q8IWA4GTPmetabolicprocessmitochondrialfusionmitochondrionlocalizationpositiveregulationofmitochondrialmembranepotential
histone acetyltransferase
3.6
48
90
Q8QZV8Q8QZV8Q8QZV8Q8QZV8histoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIIresponsetostimulusrhythmicprocess
Leupaxin
3.4
42
92
LPXNLPXNO60711O60711celladhesionendothelialcellmigrationnegativeregulationofBcellreceptorsignalingpathwaynegativeregulationofcelladhesionprotein-containingcomplexassemblyregulationofcelladhesionmediatedbyintegrinsignaltransductionsubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetareceptorsignalingpathway
Potassium voltage-gated channel subfamily D member 2
4.0
62
82
KCND2KCND2Q9NZV8Q9NZV8actionpotentialcellularresponsetohypoxiachemicalsynaptictransmissionlocomotorrhythmneuronalactionpotentialpotassiumiontransmembranetransportproteinhomooligomerizationregulationofiontransmembranetransportsensoryperceptionofpain
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
3.3
67
92
F1S031F1S031F1S031F1S031mitochondrialelectrontransportNADHtoubiquinone
Steroidogenic factor 1
3.7
43
86
STF1STF1P33242P33242adrenalglanddevelopmentcalcineurin-mediatedsignalingfemalegonaddevelopmenthormonemetabolicprocesshormone-mediatedsignalingpathwayLeydigcelldifferentiationluteinizationmaintenanceofproteinlocationinnucleusmalegonaddevelopmentmalesexdeterminationmulticellularorganismagingnegativeregulationoffemalegonaddevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofmalegonaddevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIreproductiveprocessresponsetogonadotropin-releasinghormoneSertolicelldifferentiationsexdeterminationtissuedevelopmenttranscriptionbyRNApolymeraseII
Prostaglandin E synthase 2
3.3
78
71
✔
PGES2PGES2Q9N0A4Q9N0A4prostaglandinbiosyntheticprocess
Tripartite motif-containing 25 variant
3.5
73
81
Q59GW5Q59GW5Q59GW5Q59GW5
Myelin protein zero-like protein 1
3.3
77
76
MPZL1MPZL1O95297O95297cell-cellsignalingtransmembranereceptorproteintyrosinekinasesignalingpathway
Delta-aminolevulinic acid dehydratase
3.5
83
72
HEM2HEM2P13716P13716cellularresponsetointerleukin-4cellularresponsetoleadionhemebiosyntheticprocessnegativeregulationofproteasomalproteincatabolicprocessproteinhomooligomerizationprotoporphyrinogenIXbiosyntheticprocessresponsetoactivityresponsetoaluminumionresponsetoaminoacidresponsetoarsenic-containingsubstanceresponsetocadmiumionresponsetocobaltionresponsetoethanolresponsetofattyacidresponsetoglucocorticoidresponsetoherbicideresponsetohypoxiaresponsetoionizingradiationresponsetoironionresponsetolipopolysaccharideresponsetomercuryionresponsetomethylmercuryresponsetooxidativestressresponsetoplatinumionresponsetoseleniumionresponsetovitaminB1responsetovitaminEresponsetoxenobioticstimulusresponsetozincion
DNA repair protein RAD50
3.6
64
85
RAD50RAD50Q92878Q92878cellularresponsetoDNAdamagestimuluschromosomeorganizationinvolvedinmeioticcellcycleDNAdouble-strandbreakprocessingDNAduplexunwindingDNArecombinationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairhomologousrecombinationmitoticG2/Mtransitioncheckpointnegativeregulationoftelomerecappingnucleicacidphosphodiesterbondhydrolysispositiveregulationofkinaseactivitypositiveregulationofproteinautophosphorylationpositiveregulationoftelomeremaintenancereciprocalmeioticrecombinationregulationofmitoticrecombinationtelomeremaintenancetelomeremaintenanceviarecombinationtelomeremaintenanceviatelomerase"telomeric3overhangformation"
High mobility group protein B1
3.3
53
77
✔
HMGB1HMGB1P63159P63159actincytoskeletonreorganizationactivationofinnateimmuneresponseactivationofproteinkinaseactivityapoptoticcellclearanceautophagybase-excisionrepaircellmorphogenesiscellularresponsetointerleukin-1cellularresponsetointerleukin-7cellularresponsetolipopolysaccharidechemotaxischromatinorganizationcircadianrhythmDNAgeometricchangeendothelialcellchemotaxisendothelialcellproliferationeyedevelopmentglycogencatabolicprocessheterochromatinformationinductionofpositivechemotaxisinflammatoryresponseinflammatoryresponsetoantigenicstimuluslungdevelopmentmacrophageactivationinvolvedinimmuneresponsemale-specificdefenseresponsetobacteriummyeloidcelldifferentiationmyeloiddendriticcellactivationmyeloidprogenitorcelldifferentiationmyoblastproliferationnegativeregulationofapoptoticcellclearancenegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofCD4-positivealpha-betaTcelldifferentiationnegativeregulationofDNAreplicationnegativeregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftypeIIinterferonproductionnervoussystemdevelopmentneuronprojectiondevelopmentneutrophilclearanceplasmacytoiddendriticcellactivationpositiveregulationofactivatedTcellproliferationpositiveregulationofapoptoticprocesspositiveregulationofautophagypositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelldeathpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcelldifferentiationpositiveregulationofDNAbindingpositiveregulationofDNAligationpositiveregulationofERK1andERK2cascadepositiveregulationofglycogencatabolicprocesspositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-1productionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofmacrophageinflammatoryprotein1alphaproductionpositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmismatchrepairpositiveregulationofmitoticcellcyclepositiveregulationofmonocytechemotacticprotein-1productionpositiveregulationofmonocytechemotaxispositiveregulationofmyeloidcellapoptoticprocesspositiveregulationofmyeloidcelldifferentiationpositiveregulationofmyeloidprogenitorcelldifferentiationpositiveregulationofmyoblastdifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsproutingangiogenesispositiveregulationoftoll-likereceptor2signalingpathwaypositiveregulationoftoll-likereceptor4signalingpathwaypositiveregulationoftoll-likereceptor9signalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofvascularendothelialcellproliferationpositiveregulationofwoundhealingprotein-containingcomplexassemblyregulationofinflammatoryresponseregulationofnucleotide-excisionrepairregulationofrestrictionendodeoxyribonucleaseactivityregulationofTcellmediatedimmuneresponsetotumorcellregulationoftoleranceinductionregulationoftranscriptionbyRNApolymeraseIIresponsetoglucocorticoidresponsetoglucoseresponsetoheatresponsetoinsulinresponsetolipopolysaccharideresponsetotypeIIinterferonresponsetoxenobioticstimulusT-helper1cellactivationT-helper1celldifferentiationtranscriptionbyRNApolymeraseIIV(D)Jrecombination
RAS guanyl-releasing protein 1
3.6
50
91
GRP1GRP1O95267O95267activationofGTPaseactivityBcellactivationBcellproliferationcelldifferentiationinflammatoryresponsetoantigenicstimulusmastcelldegranulationnaturalkillercellactivationpositiveregulationofERK1andERK2cascadepositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofGTPaseactivitypositiveregulationofJNKcascadepositiveregulationofMAPkinaseactivitypositiveregulationofnaturalkillercelldifferentiationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofproteinphosphorylationpositiveregulationofRasproteinsignaltransductionpositiveregulationofTcelldifferentiationinthymuspositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionRasproteinsignaltransductionregulationofERK1andERK2cascaderegulationofphosphatidylinositol3-kinasesignalingsecretorygranulelocalizationsignaltransductionTcellactivationTcellproliferationvesicletransportalongmicrotubule
Polycomb protein SUZ12
4.5
63
85
✔
SUZ12SUZ12Q15022Q15022cellpopulationproliferationdosagecompensationbyinactivationofXchromosomefacultativeheterochromatinformationhistonemethylationhistoneubiquitinationnegativeregulationofcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIoligodendrocytedifferentiationpositiveregulationofcellpopulationproliferation
Proto-oncogene vav
3.8
58
90
VAVVAVP15498P15498cellmigrationcellularresponsetoxenobioticstimulusFc-epsilonreceptorsignalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosisGprotein-coupledreceptorsignalingpathwayimmuneresponseintegrin-mediatedsignalingpathwayintracellularsignaltransductionneutrophilchemotaxisplateletactivationpositiveregulationofGTPaseactivitypositiveregulationofnaturalkillercellmediatedcytotoxicityreactiveoxygenspeciesmetabolicprocessregulationofcellsizeregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionTcellcostimulationTcelldifferentiationvascularendothelialgrowthfactorreceptorsignalingpathway
Gelsolin
3.3
81
74
GELSGELSP06396P06396actinfilamentcappingactinfilamentdepolymerizationactinfilamentpolymerizationactinfilamentreorganizationactinfilamentseveringactinpolymerizationordepolymerizationamyloidfibrilformationbarbed-endactinfilamentcappingcardiacmusclecellcontractioncellprojectionassemblycellularresponsetotypeIIinterferoncentralnervoussystemdevelopmentciliumassemblyhepatocyteapoptoticprocessnegativeregulationofviralentryintohostcellphagocytosisengulfmentpositiveregulationofactinnucleationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofkeratinocyteapoptoticprocesspositiveregulationofproteinprocessinginphagocyticvesicleproteindestabilizationregulationofestablishmentofTcellpolarityregulationofplasmamembraneraftpolarizationregulationofpodosomeassemblyregulationofreceptorclusteringrelaxationofcardiacmusclerenalproteinabsorptionresponsetomusclestretchsequesteringofactinmonomersstriatedmuscleatrophy
Citramalyl-CoA lyase, mitochondrial
3.3
78
67
CLYBLCLYBLQ8N0X4Q8N0X4positiveregulationofcobalaminmetabolicprocessproteinhomotrimerizationregulationofcobalaminmetabolicprocess
RING finger protein 113B
3.3
43
90
R113BR113BQ8IZP6Q8IZP6snoRNAsplicing
Ras-related protein Rab-1A
3.3
58
81
RAB1ARAB1AP62820P62820autophagosomeassemblyautophagycellmigrationCOPII-coatedvesiclecargoloadingdefenseresponsetobacteriumendocytosisendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationgrowthhormonesecretionintracellularproteintransportmelanosometransportpositiveregulationofglycoproteinmetabolicprocesspositiveregulationofinterleukin-8productionsubstrateadhesion-dependentcellspreadingvesicletransportalongmicrotubulevesicle-mediatedtransportvirionassembly
Iron-sulfur cluster co-chaperone protein HscB
4.2
36
83
HSC20HSC20Q8IWL3Q8IWL32Fe-2Sclusterassemblyiron-sulfurclusterassemblyprimitiveerythrocytedifferentiationprimitivehemopoiesisproteincomplexoligomerization
Hepatocyte nuclear factor 4-alpha
3.4
54
100
HNF4AHNF4AP41235P41235anatomicalstructuredevelopmentbloodcoagulationcelldifferentiationcholesterolhomeostasisglucosehomeostasislipidhomeostasislipidmetabolicprocessnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionornithinemetabolicprocessphospholipidhomeostasispositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcircadianrhythmregulationofgastrulationregulationofgrowthhormonereceptorsignalingpathwayregulationofinsulinsecretionregulationoflipidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIresponsetoglucoserhythmicprocesssexdifferentiationsignaltransductioninvolvedinregulationofgeneexpressionSMADproteinsignaltransductiontranscriptionbyRNApolymeraseIItriglyceridehomeostasisxenobioticmetabolicprocess
Cell division cycle protein 27 homolog
3.4
60
82
CDC27CDC27P30260P30260anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionmetaphase/anaphasetransitionofmitoticcellcyclepositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationproteinubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycle
Tumor necrosis factor alpha-induced protein 3
3.9
48
88
TNAP3TNAP3P21580P21580apoptoticprocessB-1BcellhomeostasiscellmigrationcellularresponsetohydrogenperoxidecellularresponsetolipopolysaccharidecytoskeletonorganizationestablishmentofproteinlocalizationtovacuoleinflammatoryresponsenegativeregulationofBcellactivationnegativeregulationofboneresorptionnegativeregulationofCD40signalingpathwaynegativeregulationofchronicinflammatoryresponsenegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinnateimmuneresponsenegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-2productionnegativeregulationofinterleukin-6productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofnucleotide-bindingoligomerizationdomaincontaining1signalingpathwaynegativeregulationofnucleotide-bindingoligomerizationdomaincontaining2signalingpathwaynegativeregulationofosteoclastproliferationnegativeregulationofproteinubiquitinationnegativeregulationofsmoothmusclecellproliferationnegativeregulationoftoll-likereceptor2signalingpathwaynegativeregulationoftoll-likereceptor3signalingpathwaynegativeregulationoftoll-likereceptor4signalingpathwaynegativeregulationoftoll-likereceptor5signalingpathwaynegativeregulationoftumornecrosisfactorproductionnucleotide-bindingoligomerizationdomaincontainingsignalingpathwaypositiveregulationofhepatocyteproliferationpositiveregulationofproteincatabolicprocesspositiveregulationofWntsignalingpathwayproteindeubiquitinationproteindeubiquitinationinvolvedinubiquitin-dependentproteincatabolicprocessproteinK11-linkeddeubiquitinationproteinK29-linkeddeubiquitinationproteinK33-linkeddeubiquitinationproteinK48-linkeddeubiquitinationproteinK48-linkedubiquitinationproteinK63-linkeddeubiquitinationregulationofdefenseresponsetovirusbyhostregulationofgerminalcenterformationregulationoftumornecrosisfactor-mediatedsignalingpathwayregulationofvascularwoundhealingresponsetomoleculeofbacterialoriginresponsetomuramyldipeptidetoleranceinductiontolipopolysaccharide
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
3.4
57
82
✔
PLCG1PLCG1P19174P19174calcium-mediatedsignalingcellmigrationcellularresponsetoepidermalgrowthfactorstimulusepidermalgrowthfactorreceptorsignalingpathwayFc-epsilonreceptorsignalingpathwayinuteroembryonicdevelopmentmodulationofchemicalsynaptictransmissionnegativeregulationofinflammatoryresponsetoantigenicstimulusphosphatidylinositolmetabolicprocessphospholipidcatabolicprocesspositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofepithelialcellmigrationpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofvascularendothelialcellproliferationTcellreceptorsignalingpathway
BTB/POZ domain-containing protein KCTD17
3.4
60
77
KCD17KCD17Q8N5Z5Q8N5Z5cellprojectionorganizationendoplasmicreticulumcalciumionhomeostasispositiveregulationofciliumassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinhomooligomerization
Cysteine-rich protein 2
3.4
44
93
CRIP2CRIP2P52943P52943hemopoiesispositiveregulationofcellpopulationproliferation
DnaJ homolog subfamily A member 3, mitochondrial
3.4
55
92
DNJA3DNJA3Q96EY1Q96EY1activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivation-inducedcelldeathofTcellscellularsenescencemitochondrialDNAreplicationmitochondrionorganizationnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteinkinaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftypeIIinterferon-mediatedsignalingpathwayneuromuscularjunctiondevelopmentpositiveregulationofapoptoticprocesspositiveregulationofproteinubiquitinationpositiveregulationofTcellproliferationproteinfoldingproteinstabilizationresponsetoheatresponsetotypeIIinterferonskeletalmuscleacetylcholine-gatedchannelclusteringsmallGTPasemediatedsignaltransductionTcelldifferentiationinthymus
Methionine--tRNA ligase, cytoplasmic
3.4
44
92
SYMCSYMCP56192P56192cellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoplatelet-derivedgrowthfactorstimulusmethionyl-tRNAaminoacylationpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseIrRNAtranscriptiontRNAaminoacylationforproteintranslation
Ras association domain-containing protein 5
3.4
46
87
RASF5RASF5O70407O70407apoptoticprocesslymphocyteproliferationnegativeregulationoflymphocyteproliferationpositiveregulationofproteinubiquitinationregulationofproteinlocalizationtonucleussignaltransduction
WD repeat and FYVE domain-containing protein 3
3.4
62
85
WDFY3WDFY3Q8IZQ1Q8IZQ1aggrephagy
Four and a half LIM domains protein 2
3.4
57
90
FHL2FHL2Q14192Q14192atrialcardiacmusclecelldevelopmenthearttrabeculaformationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastdifferentiationresponsetohormoneventricularcardiacmusclecelldevelopment
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
3.4
45
82
GLCNEGLCNEQ9Y223Q9Y223celladhesionN-acetylglucosaminebiosyntheticprocessN-acetylneuraminatemetabolicprocessUDP-N-acetylglucosaminemetabolicprocess
BRCA1-associated RING domain protein 1
2.0
55
89
BARD1BARD1Q99728Q99728cellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationDNArepairDNAstrandresectioninvolvedinreplicationforkprocessinghistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationhomologousrecombinationmitoticG2/Mtransitioncheckpointnegativeregulationofapoptoticprocessnegativeregulationofcellcycle"negativeregulationofmRNA3-endprocessing"negativeregulationofproteinexportfromnucleuspositiveregulationofapoptoticprocesspositiveregulationofproteincatabolicprocessproteinautoubiquitinationproteinK6-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofcellcycleregulationofDNAdamagecheckpointregulationofDNArepairregulationofphosphorylationtissuehomeostasis
Angiotensin-converting enzyme 2
3.5
45
80
ACE2ACE2Q9BYF1Q9BYF1angiotensinmaturationangiotensin-mediateddrinkingbehaviorbloodvesseldiametermaintenancematernalprocessinvolvedinfemalepregnancymembranefusionnegativeregulationofERK1andERK2cascadenegativeregulationofsignalingreceptoractivitynegativeregulationofsmoothmusclecellproliferationpositiveregulationofaminoacidtransportpositiveregulationofcardiacmusclecontractionpositiveregulationofgapjunctionassemblypositiveregulationofL-prolineimportacrossplasmamembranepositiveregulationofreactiveoxygenspeciesmetabolicprocessreceptor-mediatedendocytosisofvirusbyhostcellreceptor-mediatedvirionattachmenttohostcellregulationofcardiacconductionregulationofcellpopulationproliferationregulationofcytokineproductionregulationofinflammatoryresponseregulationofsystemicarterialbloodpressurebyrenin-angiotensinregulationoftransmembranetransporteractivityregulationofvasoconstrictiontryptophantransportviralentryintohostcellvirallifecycle
Nucleolar transcription factor 1
3.4
60
79
UBF1UBF1P25976P25976cellularresponsetoleukemiainhibitoryfactorpositiveregulationoftranscriptionbyRNApolymeraseItranscriptionbyRNApolymeraseItranscriptionelongationbyRNApolymeraseItranscriptioninitiationatRNApolymeraseIpromoter
Potassium voltage-gated channel subfamily C member 1
3.8
66
84
KCNC1KCNC1P48547P48547cellularresponsetoxenobioticstimuluscerebellumdevelopmentcorpuscallosumdevelopmentglobuspallidusdevelopmentopticnervedevelopmentpositiveregulationofvoltage-gatedpotassiumchannelactivitypotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationproteintetramerizationresponsetoamineresponsetoauditorystimulusresponsetofibroblastgrowthfactorresponsetolightintensityresponsetonervegrowthfactorresponsetopotassiumionresponsetotoxicsubstance
Histone acetyltransferase KAT7
3.6
57
91
KAT7KAT7O95251O95251DNArepairDNAreplicationDNAreplication-dependentchromatindisassemblyhistoneH4-K12acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationhistonemodificationinternalpeptidyl-lysineacetylationnaturalkillercelldifferentiationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofDNAreplicationpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationoferythrocytedifferentiationpositiveregulationofhematopoieticstemcellproliferationpositiveregulationofproteinlocalizationtonucleuspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleregulationofcellgrowthregulationofDNAbiosyntheticprocessregulationofDNAreplicationregulationofDNA-templatedDNAreplicationinitiationregulationofDNA-templatedtranscriptionregulationofnucleotide-excisionrepairresponsetoactinomycinDresponsetoanisomycinresponsetodithiothreitolresponsetohydroxyurearesponsetosorbitolstress-activatedproteinkinasesignalingcascadeTcelldifferentiationtranscriptioninitiation-coupledchromatinremodeling
28S ribosomal protein S25, mitochondrial
3.4
56
92
✔
RT25RT25P82663P82663mitochondrialtranslation
Sterol O-acyltransferase 1
2.0
nan
90
SOAT1SOAT1P35610P35610cholesteroleffluxcholesterolhomeostasischolesterolmetabolicprocesscholesterolstoragelow-densitylipoproteinparticleclearancemacrophagederivedfoamcelldifferentiationpositiveregulationofamyloidprecursorproteinbiosyntheticprocessvery-low-densitylipoproteinparticleassembly
Histone-lysine N-methyltransferase SETD2
3.6
48
89
SETD2SETD2Q9BYW2Q9BYW2angiogenesiscellmigrationinvolvedinvasculogenesiscoronaryvasculaturemorphogenesisdefenseresponsetovirusembryoniccranialskeletonmorphogenesisembryonicplacentamorphogenesisendodermalcelldifferentiationforebraindevelopmenthistoneH3-K36dimethylationhistoneH3-K36trimethylationmesodermmorphogenesismicrotubulecytoskeletonorganizationinvolvedinmitosismismatchrepairmorphogenesisofabranchingstructureneuraltubeclosurenucleosomeorganizationpeptidyl-lysinetrimethylationpericardiumdevelopmentpositiveregulationofinterferon-alphaproductionregulationofcytokinesisregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofgeneexpressionregulationofmRNAexportfromnucleusregulationofproteinlocalizationtochromatinresponsetotypeIinterferonstemcelldevelopmentstemcelldifferentiationtranscriptionelongationbyRNApolymeraseIIpromoter
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
3.3
55
81
✔
NDUA8NDUA8P42029P42029mitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassembly
CCR4-NOT transcription complex subunit 1
3.4
87
73
✔
CNOT1CNOT1A5YKK6A5YKK6miRNA-mediatedgenesilencingnegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationofretinoicacidreceptorsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranslationnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaynuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationofcytoplasmicmRNAprocessingbodyassemblypositiveregulationofmRNAcatabolicprocesspositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNApoly(A)tailshorteningregulationofstemcellpopulationmaintenanceRNAphosphodiesterbondhydrolysisexonucleolytictrophectodermalcelldifferentiation
DNA-directed RNA polymerase subunit beta
3.9
70
88
I3LGP4I3LGP4I3LGP4I3LGP4DNA-templatedtranscription
E3 ubiquitin-protein ligase RNF38
3.8
65
76
RNF38RNF38Q9H0F5Q9H0F5malegonaddevelopmentproteinubiquitination
Glutathione S-transferase LANCL1
3.4
85
68
LANC1LANC1O43813O43813carbohydratemetabolicprocessGprotein-coupledreceptorsignalingpathwaypeptidemodificationregulationofneuronapoptoticprocessregulationofoxidativestress-inducedneurondeath
Glycogen [starch] synthase, muscle
3.4
84
71
GYS1GYS1P13807P13807glycogenbiosyntheticprocessheartdevelopment
Zinc finger protein 268
3.4
38
92
ZN268ZN268Q14587Q14587celldifferentiationcellularresponsetotumornecrosisfactornegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationofcelldifferentiationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofproteincatabolicprocesspositiveregulationofproteinhomodimerizationactivitypositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleregulationofDNA-templatedtranscriptionregulationofmitoticcellcycleregulationofproteinheterodimerizationactivityregulationoftranscriptionbyRNApolymeraseII
Plectin
3.4
67
82
PLECPLECQ15149Q15149actincytoskeletonreorganizationactomyosincontractileringassemblyactinfilamentorganizationadherensjunctionorganizationcardiacmusclecelldevelopmentcellmorphogenesiscellularresponsetoextracellularstimuluscellularresponsetofluidshearstresscellularresponsetohydrostaticpressurecellularresponsetomechanicalstimulusestablishmentofskinbarrierfibroblastmigrationgeneexpressionhemidesmosomeassemblyintermediatefilamentcytoskeletonorganizationintermediatefilamentorganizationkeratinocytedevelopmentleukocytemigrationinvolvedinimmuneresponsemitochondrionmorphogenesismulticellularorganismgrowthmyoblastdifferentiationnegativeregulationofproteinkinaseactivitynucleusorganizationperipheralnervoussystemmyelinmaintenanceproteinlocalizationprotein-containingcomplexorganizationregulationofATPcitratesynthaseactivityregulationofvascularpermeabilityrespiratoryelectrontransportchainresponsetofoodsarcomereorganizationskeletalmusclefiberdevelopmentskeletalmyofibrilassemblyTcellchemotaxistightjunctionorganizationtransmissionofnerveimpulsewoundhealing
Ribonucleoside-diphosphate reductase large subunit
3.9
92
71
✔
RIR1RIR1P23921P23921"2-deoxyribonucleotidebiosyntheticprocess"deoxyribonucleotidebiosyntheticprocessDNArepairDNAsynthesisinvolvedinDNArepairmitochondrialDNAreplicationpositiveregulationofG0toG1transitionpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofG2/Mtransitionofmitoticcellcycleproteinheterotetramerizationribonucleosidediphosphatemetabolicprocess
Histone deacetylase complex subunit SAP30
3.4
53
82
SAP30SAP30O75446O75446modulationbyhostofsymbionttranscriptionnegativeregulationofcellmigrationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofstemcellpopulationmaintenanceregulationofDNA-templatedtranscriptionskeletalmusclecelldifferentiation
Prostaglandin reductase 2
3.4
77
79
PTGR2PTGR2Q8N8N7Q8N8N7prostaglandinmetabolicprocess
E3 ubiquitin-protein ligase MSL2
3.7
55
89
MSL2MSL2Q9HCI7Q9HCI7histoneH4-K16acetylationpositiveregulationofDNA-templatedtranscriptionproteinubiquitinationregulationofdosagecompensationbyinactivationofXchromosome
Poly(ADP-ribose) glycohydrolase
3.4
85
71
PARGPARGO88622O88622ATPgenerationfrompoly-ADP-D-ribosecarbohydratemetabolicprocesscellularresponsetoDNAdamagestimulusdetectionofbacteriumnucleotide-sugarmetabolicprocesspositiveregulationofDNArepairregulationofDNArepairregulationofhistonemodification
4-aminobutyrate aminotransferase, mitochondrial
3.4
97
64
GABTGABTP80147P80147behavioralresponsetococainegamma-aminobutyricacidcatabolicprocessneurotransmittercatabolicprocess
SUN domain-containing protein 2
3.4
86
73
SUN2SUN2Q9UH99Q9UH99centrosomelocalizationmeioticcellcyclemitoticspindleorganizationnuclearenvelopeorganizationnuclearmatrixanchoringatnuclearmembranenuclearmigrationnuclearmigrationalongmicrofilamentnucleokinesisinvolvedincellmotilityincerebralcortexradialgliaguidedmigrationpositiveregulationofcellmigration
Krueppel-like factor 4
3.4
38
91
✔
KLF4KLF4Q60793Q60793canonicalWntsignalingpathwaycellularresponsetogrowthfactorstimuluscellularresponsetolaminarfluidshearstresscellularresponsetoleukemiainhibitoryfactordefenseresponsetotumorcellDNA-templatedtranscriptionepidermalcelldifferentiationepidermisdevelopmentepidermismorphogenesisestablishmentofskinbarrierfatcelldifferentiationgeneexpressionglandularepithelialcelldifferentiationnegativeregulationofangiogenesisnegativeregulationofcellmigrationnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofchemokine(C-X-Cmotif)ligand2productionnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofERK1andERK2cascadenegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationofheterotypiccell-celladhesionnegativeregulationofinterleukin-8productionnegativeregulationofleukocyteadhesiontoarterialendothelialcellnegativeregulationofmusclehyperplasianegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofphosphatidylinositol3-kinasesignalingnegativeregulationofproteinkinaseBsignalingnegativeregulationofresponsetocytokinestimulusnegativeregulationofsmoothmusclecellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcorepromoterbindingpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofhemoglobinbiosyntheticprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofproteinmetabolicprocesspositiveregulationofsproutingangiogenesispositiveregulationoftelomeraseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryoniccamera-typeeyedevelopmentpost-embryonichemopoiesisregulationofaxonregenerationregulationofblastocystdevelopmentregulationofcelldifferentiationregulationofcellpopulationproliferationregulationoftranscriptionbyRNApolymeraseIIresponsetoorganicsubstanceresponsetoretinoicacidsomaticstemcellpopulationmaintenancestemcellpopulationmaintenancetranscriptionbyRNApolymeraseII
[F-actin]-monooxygenase MICAL1
3.4
42
93
MICA1MICA1Q8TDZ2Q8TDZ2actinfilamentbundleassemblyactinfilamentdepolymerizationcytoskeletonorganizationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofproteinphosphorylationregulationofregulatedsecretorypathwaysignaltransductionsulfuroxidation
ZZ-type zinc finger-containing protein 3
3.5
61
86
ZZZ3ZZZ3Q8IYH5Q8IYH5histoneH3acetylationhistoneH3-K14acetylationhistoneH4acetylationregulationofcellcycleregulationofcelldivisionregulationofDNA-templatedtranscriptionregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylation
Testin
3.7
43
89
TESTESQ9UGI8Q9UGI8negativeregulationofcellpopulationproliferation
Importin-9
3.4
81
75
IPO9IPO9Q96P70Q96P70proteasomelocalizationproteinimportintonucleus
Zinc finger protein GLI1
3.4
38
90
GLI1GLI1P08151P08151cerebellarcortexmorphogenesisdigestivetractmorphogenesisdorsal/ventralpatternformationepidermalcelldifferentiationliverregenerationlungdevelopmentnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofhhtargettranscriptionfactoractivitynotochordregressionosteoblastdifferentiationpituitaryglanddevelopmentpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellcycleG1/SphasetransitionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAreplicationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofsmoothenedsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIprostateglanddevelopmentproximal/distalpatternformationregulationofhepatocyteproliferationregulationofosteoblastdifferentiationregulationofsmoothenedsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetowoundingsmoothenedsignalingpathwaysmoothenedsignalingpathwayinvolvedinregulationofcerebellargranulecellprecursorcellproliferationspermatiddevelopmentventralmidlinedevelopment
Muscleblind-like protein 2
3.8
34
90
MBNL2MBNL2Q5VZF2Q5VZF2mRNAprocessingregulationofalternativemRNAsplicingviaspliceosomeregulationofRNAsplicingRNAsplicing
E3 ubiquitin-protein ligase UHRF2
3.8
38
90
UHRF2UHRF2Q96PU4Q96PU4cellcyclecelldifferentiationmaintenanceofDNAmethylationproteinautoubiquitinationproteinsumoylationproteinubiquitinationregulationofcellcycle
AP-1 complex subunit beta-1
3.4
76
78
AP1B1AP1B1Q10567Q10567basolateralproteinsecretiondeterminationofleft/rightsymmetryheartdevelopmentintracellularproteintransportkidneydevelopmentmelanosomeassemblyplateletdensegranuleorganizationvesicle-mediatedtransport
E3 ubiquitin-protein ligase RNF165
3.9
71
88
RN165RN165Q6ZSG1Q6ZSG1forelimbmorphogenesisinnervationmotorneuronaxonguidancemulticellularorganismagingmusclestructuredevelopmentpositiveregulationofBMPsignalingpathwayproteincatabolicprocessproteinpolyubiquitination
Apolipoprotein M
2.0
50
87
APOMAPOMO95445O95445cholesteroleffluxcholesterolhomeostasishigh-densitylipoproteinparticleassemblyhigh-densitylipoproteinparticleclearancehigh-densitylipoproteinparticleremodelinglipoproteinmetabolicprocessnegativeregulationofplasmalipoproteinoxidationreversecholesteroltransport
Protein phosphatase 1A
3.4
77
76
PPM1APPM1AP35813P35813cellularresponsetotransforminggrowthfactorbetastimulusdephosphorylationN-terminalproteinmyristoylationnegativeregulationofBMPsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofSMADproteincomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypeptidyl-threoninedephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinexportfromnucleusproteindephosphorylationproteinexportfromnucleusregulationofcellcycle
Aprataxin
3.4
44
85
APTXAPTXQ7Z2E3Q7Z2E3DNAligationdouble-strandbreakrepairregulationofproteinstabilitysinglestrandbreakrepair
Coagulation factor XIII A chain
3.4
93
72
F13AF13AP00488P00488bloodcoagulationbloodcoagulationfibrinclotformationpeptidecross-linking
PDZ and LIM domain protein 1
3.7
59
88
PDLI1PDLI1O00151O00151actincytoskeletonorganizationestablishmentormaintenanceofactincytoskeletonpolarityfibroblastmigrationheartdevelopmentmaintenanceofcellpolaritymusclestructuredevelopmentregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiaresponsetooxidativestressstressfiberassembly
Hsp70-binding protein 1
4.3
63
77
HPBP1HPBP1Q9NZL4Q9NZL4positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteinfolding
Zinc finger protein 483
3.9
42
91
ZN483ZN483Q8TF39Q8TF39regulationoftranscriptionbyRNApolymeraseII
Pyruvate carboxylase, mitochondrial
3.4
81
73
PYCPYCP11498P11498gluconeogenesislipidmetabolicprocessNADHmetabolicprocessNADPmetabolicprocessnegativeregulationofgeneexpressionpositiveregulationbyhostofviralprocesspyruvatemetabolicprocessviralreleasefromhostcellviralRNAgenomepackaging
DNA-directed RNA polymerase subunit beta
3.7
69
90
A5PJW8A5PJW8A5PJW8A5PJW8transcriptionbyRNApolymeraseII
AN1-type zinc finger protein 5
3.5
52
93
ZFAN5ZFAN5O88878O88878facedevelopmentfibroblastmigrationinuteroembryonicdevelopmentplatelet-derivedgrowthfactorreceptorsignalingpathwayrespiratorysystemprocessskeletalsystemmorphogenesissmoothmuscletissuedevelopmentvasculaturedevelopment
E3 ubiquitin-protein ligase CHFR
3.8
67
92
CHFRCHFRQ96EP1Q96EP1celldivisionmeioticspindlecheckpointsignalingmitoticG2/Mtransitioncheckpointmodification-dependentproteincatabolicprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteindestabilizationproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5
3.4
41
92
MACF1MACF1Q9UPN3Q9UPN3GolgitoplasmamembraneproteintransportintermediatefilamentcytoskeletonorganizationpositiveregulationofaxonextensionpositiveregulationofWntsignalingpathwayregulationofcellmigrationregulationofepithelialcellmigrationregulationoffocaladhesionassemblyregulationofmicrotubule-basedprocessregulationofneuronprojectionarborizationWntsignalingpathwaywoundhealing
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
3.4
56
76
PK3CGPI3R5P48736O02696adaptiveimmuneresponseangiogenesiscellmigrationcellularresponsetocAMPdendriticcellchemotaxisendocytosisGprotein-coupledreceptorsignalingpathwayhepatocyteapoptoticprocessimmuneresponseinflammatoryresponseinnateimmuneresponsemastcelldegranulationnaturalkillercellchemotaxisnegativeregulationofcardiacmusclecontractionnegativeregulationoffibroblastapoptoticprocessnegativeregulationoftriglyceridecatabolicprocessneutrophilchemotaxisneutrophilextravasationphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationplateletaggregationpositiveregulationofacuteinflammatoryresponsepositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofendothelialcellmigrationpositiveregulationofMAPkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofRacproteinsignaltransductionproteinphosphorylationregulationofcalciumiontransmembranetransportregulationofcelladhesionmediatedbyintegrinrespiratoryburstinvolvedindefenseresponsesecretorygranulelocalizationsphingosine-1-phosphatereceptorsignalingpathwayTcellactivationTcellchemotaxisTcellproliferation
Lysine-specific demethylase 4C
3.4
39
89
KDM4CKDM4CQ9H3R0Q9H3R0blastocystformationchromatinremodelinghistoneH3-K9demethylationpositiveregulationofcellpopulationproliferationregulationofandrogenreceptorsignalingpathwayregulationofstemcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIstemcellpopulationmaintenance
Histone-lysine N-methyltransferase, H3 lysine-36 specific
3.7
77
92
✔
NSD1NSD1O88491O88491chromatinorganizationgastrulationwithmouthformingsecondnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscriptionregulationofpeptidyl-serinephosphorylationregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbinding
Calcium/calmodulin-dependent protein kinase type 1D
3.4
86
73
✔
KCC1DKCC1DQ8IU85Q8IU85inflammatoryresponsenegativeregulationofapoptoticprocessnervoussystemdevelopmentpeptidyl-serinephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofneutrophilchemotaxispositiveregulationofphagocytosispositiveregulationofrespiratoryburstregulationofdendritedevelopmentregulationofgranulocytechemotaxis
tRNA N6-adenosine threonylcarbamoyltransferase
3.4
68
78
✔
OSGEPOSGEPQ9NPF4Q9NPF4tRNAthreonylcarbamoyladenosinemodification
DNA-binding protein SMUBP-2
3.4
96
69
SMBP2SMBP2P38935P38935DNAduplexunwindingRNAsecondarystructureunwinding
39S ribosomal protein L36, mitochondrial
3.7
38
84
RM36RM36Q9P0J6Q9P0J6mitochondrialtranslationribosomebiogenesistranslation
Tax1-binding protein 1
3.4
49
84
TAXB1TAXB1Q86VP1Q86VP1apoptoticprocessautophagyinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofNF-kappaBtranscriptionfactoractivity
Endonuclease 8-like 3
3.2
54
89
NEIL3NEIL3Q8K203Q8K203base-excisionrepairinterstrandcross-linkrepair
Kinetochore-associated protein 1
3.4
64
77
KNTC1KNTC1P50748P50748celldivisionmitoticsisterchromatidsegregationmitoticspindleassemblycheckpointsignalingproteinlocalizationtokinetochoreinvolvedinkinetochoreassemblyprotein-containingcomplexassemblyregulationofexitfrommitosis
RNA polymerase II subunit K
3.4
53
84
A0A4X1TRS6A0A4X1TRS6A0A4X1TRS6A0A4X1TRS6transcriptionbyRNApolymeraseII
Proteasome subunit alpha type-6
3.4
81
70
✔
PSA6PSA6P60901P60901positiveregulationofNF-kappaBtranscriptionfactoractivityproteasomalproteincatabolicprocessproteolysisinvolvedinproteincatabolicprocessubiquitin-dependentproteincatabolicprocess
Protection of telomeres protein 1
3.5
62
87
POTE1POTE1Q9NUX5Q9NUX5DNAduplexunwindingestablishmentofproteinlocalizationtotelomerenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomerasepositiveregulationofDNAhelicaseactivitypositiveregulationofDNAstrandelongationpositiveregulationofhelicaseactivitypositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenancepositiveregulationoftelomeremaintenanceviatelomeraseregulationofDNAhelicaseactivityregulationofdouble-strandbreakrepairvianonhomologousendjoiningregulationoftelomeremaintenanceviatelomerasetelomereassemblytelomerecappingtelomeremaintenanceviatelomerasetelomericD-loopdisassembly
Serine/threonine-protein kinase VRK2
3.4
67
81
VRK2VRK2Q86Y07Q86Y07cellularresponsetooxidativestresspeptidyl-serinephosphorylationproteinautophosphorylationproteinphosphorylationregulationofinterleukin-1-mediatedsignalingpathwayregulationofMAPKcascadesignaltransduction
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
3.5
87
75
A0A287BG40A0A287BG40A0A287BG40A0A287BG40cardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopment
40S ribosomal protein S29
3.6
55
89
RS29RS29P62273P62273cytoplasmictranslationtranslation
Polycomb complex protein BMI-1
3.8
48
90
✔
BMI1BMI1P35226P35226apoptoticsignalingpathwaybraindevelopmentcellularresponsetodexamethasonestimuluscellularresponsetointerleukin-1DNAmethylationembryonicskeletalsystemmorphogenesishemopoiesishistoneacetylationhistoneH2A-K119monoubiquitinationhumoralimmuneresponseinuteroembryonicdevelopmentnegativeregulationofapoptoticsignalingpathwaynegativeregulationofgeneexpressionepigeneticnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofBcellproliferationpositiveregulationoffibroblastproliferationpositiveregulationofimmatureTcellproliferationinthymuspositiveregulationofubiquitin-proteintransferaseactivityregulationofadaxial/abaxialpatternformationregulationofgeneexpressionrostrocaudalneuraltubepatterningsegmentspecificationsomaticstemcelldivision
Probable E3 ubiquitin-protein ligase DTX2
4.0
35
81
DTX2DTX2Q86UW9Q86UW9Notchsignalingpathwayproteinubiquitination
26S proteasome non-ATPase regulatory subunit 1
3.5
61
81
✔
PSMD1PSMD1O88761O88761proteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofproteincatabolicprocess
Rap guanine nucleotide exchange factor 4
3.4
92
68
RPGF4RPGF4Q9EQZ6Q9EQZ6adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycalcium-ionregulatedexocytosishormonesecretioninsulinsecretionnegativeregulationofsynaptictransmissionpositiveregulationofGTPaseactivitypositiveregulationofinsulinsecretionpositiveregulationofneuronalactionpotentialpositiveregulationofproteinsecretionpositiveregulationofsmoothmusclecellmigrationRasproteinsignaltransductionregulationofdendritedevelopmentregulationofexocytosisregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofpostsynapseorganizationregulationofsynapticvesiclecyclesignaltransduction
Transcription initiation factor TFIID subunit 3
3.7
47
88
TAF3TAF3Q5HZG4Q5HZG4maintenanceofproteinlocationinnucleusmRNAtranscriptionbyRNApolymeraseIInegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinphosphorylationregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseII
Sphingomyelin phosphodiesterase 3
3.4
92
68
NSMA2NSMA2Q9NY59Q9NY59BMPsignalingpathwaybonegrowthbonemineralizationcellularresponsetohydrogenperoxidecellularresponsetomagnesiumioncellularresponsetooxidisedlow-densitylipoproteinparticlestimuluscellularresponsetopeptidecellularresponsetoredoxstatecellularresponsetotumornecrosisfactorceramidemetabolicprocesschondrocytedevelopmentinvolvedinendochondralbonemorphogenesiscollagenmetabolicprocessdentinogenesisDNAbiosyntheticprocessendochondralossificationextracellularmatrixassemblyG1toG0transitionhematopoieticprogenitorcelldifferentiationlungalveolusdevelopmentmitoticnucleardivisionmulticellularorganismgrowthnegativeregulationofhyaluronanbiosyntheticprocesspeptidehormonesecretionplatelet-derivedgrowthfactorreceptorsignalingpathwaypolysaccharidetransportpositiveregulationofexosomalsecretionpositiveregulationofmitoticnucleardivisionpositiveregulationofsmoothmusclecellproliferationproteinkinaseBsignalingregulationofcartilagedevelopmentregulationofleukocytemigrationregulationofproteinphosphorylationsphingolipidmediatedsignalingpathwaysphingomyelincatabolicprocesssphingomyelinmetabolicprocess
Zinc finger protein 217
3.4
37
88
ZN217ZN217O75362O75362negativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscription
DNA-directed RNA polymerase subunit beta
4.1
61
85
A0A4X1TVZ5A0A4X1TVZ5A0A4X1TVZ5A0A4X1TVZ5DNA-templatedtranscription
Lysine-specific demethylase 6B
3.6
54
84
KDM6BKDM6BO15054O15054cardiacmusclecelldifferentiationcellfatecommitmentcellularresponsetohydrogenperoxidechromatinremodelingendothelialcelldifferentiationheartdevelopmenthistoneH3-K27demethylationinflammatoryresponsemesodermalcelldifferentiationpositiveregulationofcold-inducedthermogenesispositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpression
Histone-lysine N-methyltransferase NSD3
3.8
54
90
NSD3NSD3Q9BZ95Q9BZ95chromatinorganizationpositiveregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscription
Fatty acid synthase
3.8
64
82
FASFASP49327P49327cellularresponsetointerleukin-4establishmentofendothelialintestinalbarrieretherlipidbiosyntheticprocessfattyacidbiosyntheticprocessfattyacidmetabolicprocessglandularepithelialcelldevelopmentinflammatoryresponsemammaryglanddevelopmentmodulationbyhostofviralprocessmonocytedifferentiationneutrophildifferentiationosteoblastdifferentiation
Protein lin-54 homolog
3.8
54
95
LIN54LIN54Q6MZP7Q6MZP7cellcyclenucleosomeorganizationregulationofDNA-templatedtranscription
Protein Mis18-alpha
3.6
53
88
MS18AMS18AQ9NYP9Q9NYP9celldivisionCENP-AcontainingchromatinassemblychromosomesegregationregulationofDNAmethylation
Baculoviral IAP repeat-containing protein 2
3.6
59
92
BIRC2BIRC2Q13490Q13490cellsurfacereceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalingnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofnecroptoticprocessnegativeregulationofripoptosomeassemblyinvolvedinnecroptoticprocessNIK/NF-kappaBsignalingplacentadevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinK48-linkedubiquitinationpositiveregulationofproteinK63-linkedubiquitinationpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcelldifferentiationregulationofcellpopulationproliferationregulationofcysteine-typeendopeptidaseactivityregulationofinflammatoryresponseregulationofinnateimmuneresponseregulationofnecroptoticprocessregulationofNIK/NF-kappaBsignalingregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayregulationofreactiveoxygenspeciesmetabolicprocessregulationofRIG-Isignalingpathwayregulationoftoll-likereceptorsignalingpathwayresponsetocAMPresponsetoethanolresponsetohypoxiatumornecrosisfactor-mediatedsignalingpathway
Tyrosine 3-monooxygenase
3.4
70
76
TY3HTY3HP07101P07101aminergicneurotransmitterloadingintosynapticvesicleanatomicalstructuremorphogenesisanimalorganmorphogenesiscellularresponsetoalkaloidcellularresponsetoglucosestimuluscellularresponsetogrowthfactorstimuluscellularresponsetomanganeseioncellularresponsetonicotinecellularresponsetoxenobioticstimuluscerebralcortexdevelopmentcircadiansleep/wakecycledopaminebiosyntheticprocessdopaminebiosyntheticprocessfromtyrosineeatingbehaviorembryoniccamera-typeeyemorphogenesisepinephrinebiosyntheticprocesseyephotoreceptorcelldevelopmentfattyacidmetabolicprocessglycosidemetabolicprocessheartdevelopmentheartmorphogenesishyaloidvascularplexusregressionisoquinolinealkaloidmetabolicprocesslearninglocomotorybehaviormatingbehaviormemorymulticellularorganismagingneurotransmitterbiosyntheticprocessnorepinephrinebiosyntheticprocessphthalatemetabolicprocessphytoalexinmetabolicprocesspigmentationregulationofheartcontractionresponsetoactivityresponsetoamphetamineresponsetocorticosteroneresponsetoelectricalstimulusresponsetoestradiolresponsetoethanolresponsetoetherresponsetoherbicideresponsetohypoxiaresponsetoimmobilizationstressresponsetoisolationstressresponsetolightstimulusresponsetolipopolysaccharideresponsetonutrientlevelsresponsetopeptidehormoneresponsetopyrethroidresponsetosaltstressresponsetowaterdeprivationresponsetozincionsensoryperceptionofsoundsocialbehaviorsphingolipidmetabolicprocesssynaptictransmissiondopaminergicterpenemetabolicprocessvisualperception
Nucleosome-remodeling factor subunit BPTF
3.6
50
87
BPTFBPTFQ12830Q12830anterior/posteriorpatternspecificationbraindevelopmentchromatinremodelingembryonicplacentadevelopmentendodermdevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Alcohol dehydrogenase 1A
3.5
51
88
ADH1AADH1AP07327P07327alcoholmetabolicprocessethanoloxidationretinoicacidmetabolicprocessretinolmetabolicprocess
Intraflagellar transport protein 122 homolog
3.6
41
85
IF122IF122Q9HBG6Q9HBG6camera-typeeyemorphogenesisciliumassemblyembryonicbodymorphogenesisembryonichearttubedevelopmentintraciliaryretrogradetransportintraciliarytransportlimbdevelopmentnegativeregulationofsmoothenedsignalingpathwayneuraltubeclosurenon-motileciliumassemblyproteinlocalizationtocilium
Lon protease homolog, mitochondrial
3.4
77
72
LONMLONMP36776P36776agingcellularresponsetooxidativestresschaperone-mediatedproteincomplexassemblymitochondrialDNAmetabolicprocessmitochondrialgenomemaintenancemitochondrionorganizationnegativeregulationofinsulinreceptorsignalingpathwayoxidation-dependentproteincatabolicprocessproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsproteolysisinvolvedinproteincatabolicprocessregulationofpeptidyl-tyrosinephosphorylationresponsetoaluminumionresponsetohormoneresponsetohypoxia
5-methylcytosine rRNA methyltransferase NSUN4
3.4
75
74
NSUN4NSUN4Q96CB9Q96CB9RNAmethylationrRNAmethylation
Ubiquitin carboxyl-terminal hydrolase 1
3.8
60
84
UBP1UBP1O94782O94782DNArepairmonoubiquitinatedproteindeubiquitinationpositiveregulationoferror-pronetranslesionsynthesisproteindeubiquitinationregulationofDNArepairresponsetoUVskeletalsystemdevelopmentubiquitin-dependentproteincatabolicprocess
Glucagon-like peptide 1 receptor
2.0
71
83
GLP1RGLP1RP43220P43220activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycAMP-mediatedsignalingcellsurfacereceptorsignalingpathwayhormonesecretionlearningormemorynegativeregulationofbloodpressurepositiveregulationofbloodpressurepositiveregulationofcytosoliccalciumionconcentrationpost-translationalproteintargetingtomembranetranslocationregulationofheartcontractionresponsetopsychosocialstress
Metallothionein-2
3.6
46
93
MT2MT2P04355P04355cellularresponsetocadmiumioncellularresponsetocopperioncellularresponsetoerythropoietincellularresponsetozincioncellularzincionhomeostasisdetoxificationofcopperionnegativeregulationofgrowth
Polymerase
3.4
76
70
V9H0F6V9H0F6V9H0F6V9H0F6DNArepair
Protein virilizer homolog
3.5
78
68
VIRVIRQ69YN4Q69YN4mRNAalternativepolyadenylationmRNAmethylationmRNAprocessingRNAsplicing
Protein CBFA2T1
3.6
53
90
MTG8MTG8Q06455Q06455negativeregulationofDNA-templatedtranscriptionnegativeregulationoffatcelldifferentiation
Histone acetyltransferase KAT8
3.4
58
92
KAT8KAT8Q9H7Z6Q9H7Z6chromatinorganizationhistoneH4-K16acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationmyeloidcelldifferentiationnegativeregulationofDNA-templatedtranscriptionneurogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationofhistoneH3-K4methylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofautophagyregulationofdosagecompensationbyinactivationofXchromosome
Vitamin D3 receptor
3.6
48
90
VDRVDRP11473P11473apoptoticprocessinvolvedinmammaryglandinvolutionbileacidsignalingpathwaycalciumiontransportcelldifferentiationcellmorphogenesiscellularcalciumionhomeostasisdecidualizationintestinalabsorptionlactationmammaryglandbranchinginvolvedinpregnancymRNAtranscriptionbyRNApolymeraseIInegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofkeratinocyteproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofbonemineralizationpositiveregulationofgeneexpressionpositiveregulationofkeratinocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvitaminD24-hydroxylaseactivitypositiveregulationofvitaminDreceptorsignalingpathwayregulationofcalcidiol1-monooxygenaseactivityskeletalsystemdevelopmentvitaminDreceptorsignalingpathway
PDZ and LIM domain protein 5
3.4
46
90
PDLI5PDLI5Q96HC4Q96HC4actincytoskeletonorganizationcellgrowthinvolvedincardiacmusclecelldevelopmentheartdevelopmentmusclestructuredevelopmentregulationofdendriticspinemorphogenesisregulationofsynapseassembly
Kinesin-like protein KIF2C
4.0
57
73
KIF2CKIF2CQ99661Q99661attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionestablishmentormaintenanceofmicrotubulecytoskeletonpolaritymetaphaseplatecongressionmicrotubuledepolymerizationmicrotubule-basedmovementmitoticmetaphaseplatecongressionregulationofchromosomesegregation
GTP-binding protein Di-Ras1
3.4
48
82
✔
DIRA1DIRA1O95057O95057signaltransduction
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
4.3
85
78
NDUS1NDUS1Q91VD9Q91VD9aerobicrespirationapoptoticmitochondrialchangesATPmetabolicprocesscellularrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
3.4
86
82
F1SHD7F1SHD7F1SHD7F1SHD7ATPsynthesiscoupledelectrontransport
Peroxisome proliferator-activated receptor alpha
3.4
48
84
PPARAPPARAQ07869Q07869behavioralresponsetonicotinecelldifferentiationcellularresponsetostarvationcircadianregulationofgeneexpressionenamelmineralizationepidermisdevelopmentfattyacidmetabolicprocessgluconeogenesisheartdevelopmenthormone-mediatedsignalingpathwaylipidlocalizationlipoproteinmetabolicprocessnegativeregulationofappetitenegativeregulationofbloodpressurenegativeregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentnegativeregulationofcholesterolstoragenegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofglycolyticprocessnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofinflammatoryresponsenegativeregulationofleukocytecell-celladhesionnegativeregulationofmacrophagederivedfoamcelldifferentiationnegativeregulationofmiRNAtranscriptionnegativeregulationofneurondeathnegativeregulationofproteinbindingnegativeregulationofproteinkinaseBsignalingnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofsequesteringoftriglyceridenegativeregulationofsignalingreceptoractivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofATPbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationoffattyacidbeta-oxidationpositiveregulationoffattyacidmetabolicprocesspositiveregulationoffattyacidoxidationpositiveregulationofgluconeogenesispositiveregulationoflipidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofviralgenomereplicationregulationofcellularketonemetabolicprocessregulationofcircadianrhythmregulationoffattyacidmetabolicprocessregulationoffattyacidtransportregulationoflipidmetabolicprocessresponsetoethanolresponsetohypoxiaresponsetoinsulinresponsetolipidwoundhealing
Calcium/calmodulin-dependent protein kinase kinase 2
3.4
77
75
KKCC2KKCC2Q96RR4Q96RR4activationofproteinkinaseactivitycalcium-mediatedsignalingCAMKK-AMPKsignalingcascadecellularresponsetoreactiveoxygenspeciesMAPKcascadepositiveregulationofautophagyofmitochondrionpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinphosphorylationproteinautophosphorylationproteinphosphorylationregulationofproteinkinaseactivitysignaltransduction
ATP-citrate synthase
3.4
61
80
ACLYACLYP53396P53396acetyl-CoAbiosyntheticprocesscholesterolbiosyntheticprocesscitratemetabolicprocesscoenzymeAmetabolicprocessfattyacidbiosyntheticprocesslipidbiosyntheticprocessoxaloacetatemetabolicprocesstricarboxylicacidcycle
N-lysine methyltransferase KMT5A
3.4
62
73
KMT5AKMT5AQ9NQR1Q9NQR1celldivisionchromatinorganizationmitoticchromosomecondensationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-lysinemonomethylationregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionbyRNApolymeraseII
C-C chemokine receptor type 3
3.4
64
78
CCR3CCR3P51677P51677adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycalcium-mediatedsignalingcelladhesioncellchemotaxiscellulardefenseresponsechemotaxisimmuneresponseinflammatoryresponsepositiveregulationofangiogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofendothelialcellproliferation
DNA polymerase kappa
3.4
78
78
POLKPOLKQ9UBT6Q9UBT6cellularresponsetoDNAdamagestimuluscellularresponsetoUVDNArepairDNAreplicationerror-pronetranslesionsynthesisnucleotide-excisionrepairDNAgapfilling
Chorion-specific transcription factor GCMa
4.2
43
83
GCM1GCM1P70348P70348astrocytefatecommitmentbranchinginvolvedinlabyrinthinelayermorphogenesiscelldifferentiationinvolvedinembryonicplacentadevelopmentgliogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationofsyncytiumformationbyplasmamembranefusionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcelldifferentiationinvolvedinembryonicplacentadevelopmentregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIsyncytiumformationbyplasmamembranefusiontranscriptionbyRNApolymeraseII
Protein RCC2
3.4
99
65
RCC2RCC2Q9P258Q9P258activationofGTPaseactivitycellcyclecelldivisionchromosomepassengercomplexlocalizationtokinetochoreestablishmentofproteinlocalizationfocaladhesionassemblyintegrin-mediatedsignalingpathwaynegativeregulationoffocaladhesionassemblynegativeregulationofGTPaseactivitynegativeregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofattachmentofspindlemicrotubulestokinetochorepositiveregulationofG2/Mtransitionofmitoticcellcycleregulationofcellmigrationregulationoffibroblastmigrationregulationofruffleassembly
E3 ubiquitin-protein ligase MYCBP2
3.7
49
88
MYCB2MYCB2O75592O75592axonguidancebranchiomotorneuronaxonguidancecentralnervoussystemprojectionneuronaxonogenesiscircadianregulationofgeneexpressionnegativeregulationofproteincatabolicprocessneuromuscularprocesspositiveregulationofproteinubiquitinationproteinubiquitinationregulationofaxonguidanceregulationofcytoskeletonorganizationregulationofproteinlocalizationregulationofsynapticassemblyatneuromuscularjunction
E3 ubiquitin-protein ligase TRIM21
3.8
71
78
RO52RO52P19474P19474cellcyclecellularresponsetochemicalstressinnateimmuneresponsenegativeregulationofinnateimmuneresponsenegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteindeubiquitinationnegativeregulationofviraltranscriptionpositiveregulationofautophagypositiveregulationofcellcyclepositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinbindingpositiveregulationofviralentryintohostcellproteinautoubiquitinationproteindestabilizationproteinK63-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofgeneexpressionregulationofproteinlocalizationregulationoftypeIinterferonproductionregulationofviralentryintohostcellresponsetotypeIIinterferonsuppressionofviralreleasebyhost
40S ribosomal protein S27
3.4
44
86
RS27RS27P42677P42677cytoplasmictranslationribosomalsmallsubunitassemblyrRNAprocessingtranslation
Leucine carboxyl methyltransferase 1
3.4
89
68
✔
LCMT1LCMT1Q9UIC8Q9UIC8C-terminalproteinmethylationG2/Mtransitionofmitoticcellcyclenegativeregulationofprotein-containingcomplexassemblyproteinmethylationproteinmodificationprocessregulationofapoptoticprocessregulationofglucosemetabolicprocessregulationofmitoticcellcyclespindleassemblycheckpoint
Schlafen family member 5
3.4
48
85
SLFN5SLFN5Q08AF3Q08AF3celldifferentiation
DNA dC->dU-editing enzyme APOBEC-3A
3.4
67
85
ABC3AABC3AP31941P31941cellularresponsetoxenobioticstimulusclearanceofforeignintracellularDNAcytidinetouridineeditingdefenseresponsetovirusDNAcytosinedeaminationDNAdemethylationinnateimmuneresponsenegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftranspositionnegativeregulationofviralgenomereplication
F-box/LRR-repeat protein 19
3.5
nan
95
FXL19FXL19Q6PCT2Q6PCT2proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindemethylationregulationoftranscriptionbyRNApolymeraseII
DNA replication licensing factor MCM3
3.5
70
85
MCM3MCM5P25205P33992DNAreplicationinitiationDNAstrandelongationinvolvedinDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviabreak-inducedreplicationmitoticDNAreplicationinitiationregulationofDNA-templatedDNAreplicationinitiationcellcycleDNAreplication
Stromal membrane-associated protein 1
3.9
63
85
✔
SMAP1SMAP1Q6PK24Q6PK24positiveregulationoferythrocytedifferentiationregulationofclathrin-dependentendocytosis
G protein-coupled receptor kinase-interactor 2
3.8
78
83
Q80XR8Q80XR8Q80XR8Q80XR8phosphorylation
Annexin
3.5
66
77
Q6FHB6Q6FHB6Q6FHB6Q6FHB6
Splicing factor 3A subunit 3
3.5
61
77
✔
SF3A3SF3A3Q12874Q12874"mRNA3-splicesiterecognition"mRNAprocessingmRNAsplicingviaspliceosomeRNAsplicingviatransesterificationreactionsU2-typeprespliceosomeassembly
RING finger protein unkempt homolog
4.0
42
91
UNKUNKQ8BL48Q8BL48cellmorphogenesisinvolvedinneurondifferentiationinuteroembryonicdevelopmentnegativeregulationofcytoplasmictranslationneuronmigration
E3 ubiquitin-protein ligase RING2
3.9
48
89
RING2RING2Q99496Q99496anterior/posterioraxisspecificationchromatinremodelinggastrulationwithmouthformingsecondgeneexpressiongermcelldevelopmenthistoneH2AmonoubiquitinationhistoneH2A-K119monoubiquitinationmitoticcellcyclenegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseII
DNA-directed RNA polymerase II subunit RPB3
3.5
35
88
A0A481DF93A0A481DF93A0A481DF93A0A481DF93DNA-templatedtranscription
Single-stranded DNA cytosine deaminase
3.5
64
83
AICDAAICDAQ9GZX7Q9GZX7BcelldifferentiationcellularresponsetolipopolysaccharidecytidinetouridineeditingdefenseresponsetobacteriumdefenseresponsetovirusDNAcytosinedeaminationDNAdemethylationisotypeswitchingmRNAprocessingnegativeregulationofDNAmethylation-dependentheterochromatinformationnegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatenegativeregulationoftranspositionregulationofnuclearcellcycleDNAreplicationsomaticdiversificationofimmunoglobulinssomatichypermutationofimmunoglobulingenes
DNA-directed primase/polymerase protein
3.5
55
80
PRIPOPRIPOQ96LW4Q96LW4error-pronetranslesionsynthesismitochondrialDNArepairmitochondrialDNAreplicationR-loopprocessingreplicationforkprocessingresponsetoUVtranslesionsynthesis
E3 ubiquitin-protein ligase TRIM63
3.6
55
86
TRI63TRI63Q969Q1Q969Q1musclecontractionnegativeregulationofcardiacmusclehypertrophyproteinubiquitinationresponsetoelectricalstimulusinvolvedinregulationofmuscleadaptationresponsetoglucocorticoidresponsetointerleukin-1signaltransductionskeletalmuscleatrophy
Integrator complex subunit 12
3.5
44
90
INT12INT12Q9D168Q9D168"snRNA3-endprocessing"snRNAprocessing
Gamma-aminobutyric acid receptor subunit beta-3
3.5
74
73
GBRB3GBRB3P28472P28472cellularresponsetohistaminechemicalsynaptictransmissionchloridetransmembranetransportgamma-aminobutyricacidsignalingpathwayinhibitorysynapseassemblyiontransmembranetransportnervoussystemprocessregulationofmembranepotentialroofofmouthdevelopmentsignaltransductionsynaptictransmissionGABAergic
Cytoplasmic dynein 1 heavy chain 1
3.9
61
78
✔
DYHC1DYHC1Q14204Q14204celldivisioncytoplasmicmicrotubuleorganizationestablishmentofspindlelocalizationmicrotubule-basedmovementminus-end-directedvesicletransportalongmicrotubulemitoticcellcyclemitoticspindleorganizationnuclearmigrationP-bodyassemblypositiveregulationofcold-inducedthermogenesispositiveregulationofintracellulartransportpositiveregulationofspindleassemblyregulationofmetaphaseplatecongressionregulationofmitoticspindleorganizationretrogradeaxonaltransportstressgranuleassembly
Ubiquitin-conjugating enzyme E2 E2
3.5
71
76
UB2E2UB2E2Q96LR5Q96LR5cellularresponsetoDNAdamagestimulusISG15-proteinconjugationpositiveregulationofG1/StransitionofmitoticcellcycleproteinK11-linkedubiquitinationproteinK48-linkedubiquitinationproteinK63-linkedubiquitinationproteinpolyubiquitination
Early endosome antigen 1
3.9
47
86
EEA1EEA1Q15075Q15075chemicalsynaptictransmissionpostsynapticearlyendosometolateendosometransportendocytosismodulationbyhostofviralprocesssynapticvesicletoendosomefusionvesiclefusion
Ski-like protein
3.5
48
88
SKILSKILP12757P12757blastocystformationextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagelensfibercelldifferentiationlymphocytehomeostasisnegativeregulationofBMPsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofaxonogenesispositiveregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageregulationofcellcycleresponsetoantibioticresponsetocytokineresponsetogrowthfactorskeletalmuscletissuedevelopmentspermatogenesistransforminggrowthfactorbetareceptorsignalingpathway
CST complex subunit CTC1
3.6
53
86
CTC1CTC1Q2NKJ3Q2NKJ3agingbonemarrowdevelopmentcellularresponsetoDNAdamagestimulushematopoieticstemcellproliferationmulticellularorganismgrowthnegativeregulationoftelomeremaintenanceviatelomerasepositiveregulationofDNAreplicationpositiveregulationoffibroblastproliferationregulationofG2/Mtransitionofmitoticcellcyclereplicativesenescencespleendevelopmenttelomerecappingtelomeremaintenancetelomeremaintenanceviatelomerelengtheningthymusdevelopment
DNA polymerase epsilon catalytic subunit A
3.5
45
91
DPOE1DPOE1Q07864Q07864base-excisionrepairgap-fillingDNAreplicationDNAreplicationproofreadingDNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationembryonicorgandevelopmentG1/Stransitionofmitoticcellcycleleadingstrandelongationmitoticcellcyclenucleotide-excisionrepairDNAgapfilling
Regulatory-associated protein of mTOR
3.5
71
74
RPTORRPTORQ8N122Q8N122cellularresponsetoaminoacidstimuluscellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetoleucinecellularresponsetonutrientlevelscellularresponsetoosmoticstresscellularresponsetostarvationnegativeregulationofautophagyphosphorylationpositiveregulationofcellgrowthpositiveregulationofendothelialcellproliferationpositiveregulationofG1/Stransitionofmitoticcellcyclepositiveregulationofglycolyticprocesspositiveregulationoflipidbiosyntheticprocesspositiveregulationofpentose-phosphateshuntpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofTORsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIIregulationofautophagyregulationofcellgrowthregulationofcellsizeresponsetoxenobioticstimulussocialbehaviorTORsignalingTORC1signaling
T-cell surface glycoprotein CD8 alpha chain
3.8
34
89
CD8ALCKP01732P06239adaptiveimmuneresponseantigenprocessingandpresentationcellsurfacereceptorsignalingpathwaycytotoxicTcelldifferentiationimmuneresponseTcellactivationTcellmediatedimmunityTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellactivationpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcelldifferentiation
PHD finger protein 1
3.7
67
93
PHF1PHF1Q9Z1B8Q9Z1B8cellularresponsetoDNAdamagestimuluschromatinorganizationnegativeregulationofhistoneH3-K27methylationpositiveregulationofhistoneH3-K27methylationregulationofDNA-templatedtranscription
ATP-sensitive inward rectifier potassium channel 8
1.8
58
84
KCNJ8KCNJ8Q63664Q63664defenseresponsetovirusheartdevelopmentinorganiccationtransmembranetransportkidneydevelopmentmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionimportacrossplasmamembranepotassiumiontransportregulationofiontransmembranetransportresponsetoexogenousdsRNAresponsetolipopolysaccharide
DNA-directed RNA polymerases I, II, and III subunit RPABC5
3.8
101
78
A0A4X1VYD0A0A4X1VYD0A0A4X1VYD0A0A4X1VYD0DNA-templatedtranscription
Protein Churchill
4.0
59
89
CHURCHURQ8WUH1Q8WUH1fibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofDNA-templatedtranscription
Synaptonemal complex protein 1
3.5
51
82
SYCP1SYCP1Q15431Q15431celldivisionchiasmaassemblyhomologouschromosomepairingatmeiosislateralelementassemblymeioticDNArepairsynthesisproteinhomotetramerizationreciprocalmeioticrecombinationregulationofproteinlocalizationspermDNAcondensationspermatogenesissynaptonemalcomplexassembly
Alpha-soluble NSF attachment protein
3.5
75
77
SNAASNAAP54921P54921apicalproteinlocalizationbraindevelopmentintracellularproteintransportmembranefusionneurondifferentiationpositiveregulationofATP-dependentactivityprotein-containingcomplexdisassemblyregulationofsynapticvesicleprimingSNAREcomplexdisassemblysynaptictransmissionglutamatergicsynapticvesiclepriming
DNA mismatch repair protein Msh6
4.0
72
73
MSH6MSH6P52701P52701determinationofadultlifespanDNArepairintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageisotypeswitchingmeioticmismatchrepairmismatchrepairnegativeregulationofDNArecombinationpositiveregulationofhelicaseactivityresponsetoUVsomatichypermutationofimmunoglobulingenessomaticrecombinationofimmunoglobulingenesegmentsspermatogenesis
Sterol O-acyltransferase 2
3.5
67
76
SOAT2SOAT2O75908O75908cholesteroleffluxcholesterolhomeostasischolesterolmetabolicprocessintestinalcholesterolabsorptionlow-densitylipoproteinparticleclearancemacrophagederivedfoamcelldifferentiationvery-low-densitylipoproteinparticleassembly
Nonsense-mediated mRNA decay factor SMG8
3.7
63
90
SMG8SMG8Q8ND04Q8ND04nuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecayregulationofproteinkinaseactivity
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
3.4
74
71
NDUS6NDUS6P23934P23934mitochondrialelectrontransportNADHtoubiquinone
Zinc finger CCCH domain-containing protein 4
3.5
47
93
ZC3H4ZC3H4Q9UPT8Q9UPT8DNA-templatedtranscriptionterminationlncRNAcatabolicprocessnegativeregulationofDNA-templatedtranscriptionelongationnegativeregulationoflncRNAtranscriptionnuclearRNAsurveillance
Protein ZNRD2
3.6
50
86
✔
ZNRD2ZNRD2O60232O60232celldivisionmitoticcellcycle
Protein Mdm4
3.6
49
93
MDM4MDM4O15151O15151atrialseptumdevelopmentatrioventricularvalvemorphogenesiscellularresponsetohypoxiaDNAdamageresponsesignaltransductionbyp53classmediatorendocardialcushionmorphogenesisheartvalvedevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationprotein-containingcomplexassemblyregulationofcellcycleregulationoftranscriptionbyRNApolymeraseIIventricularseptumdevelopment
Bromodomain adjacent to zinc finger domain protein 2A
3.9
71
90
BAZ2ABAZ2AQ9UIF9Q9UIF9chromatinremodelingDNAmethylationDNA-templatedtranscriptionheterochromatinformationhistonedeacetylationnegativeregulationoftranscriptionbyRNApolymeraseIpositiveregulationofhistonedeacetylationpositiveregulationofhistonemethylationrDNAheterochromatinformationregulationofDNAmethylationregulationofDNA-templatedtranscriptionRNApolymeraseIpreinitiationcomplexassembly
Protein angel homolog 2
3.5
80
72
ANGE2ANGE2Q5VTE6Q5VTE6"3-UTR-mediatedmRNAstabilization"negativeregulationofmitoticcellcycle
DNA excision repair protein ERCC-1
3.5
54
85
ERCC1ERCC1P07992P07992cellpopulationproliferationDNArepairdouble-strandbreakrepairvianonhomologousendjoiningembryonicorgandevelopmentinterstrandcross-linkrepairisotypeswitchingmalegonaddevelopmentmeioticmismatchrepairmitoticrecombinationmulticellularorganismagingmulticellularorganismgrowthnegativeregulationofprotectionfromnon-homologousendjoiningattelomerenegativeregulationoftelomeremaintenancenucleotide-excisionrepairoogenesispositiveregulationoft-circleformationpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIpost-embryonichemopoiesispyrimidinedimerrepairbynucleotide-excisionrepairreplicativesenescenceresponsetocadmiumionresponsetoimmobilizationstressresponsetonutrientresponsetooxidativestressresponsetosucroseresponsetoX-rayspermatogenesissyncytiumformationt-circleformationtelomericDNA-containingdoubleminutesformationUVprotectionUV-damageexcisionrepair
Histone-lysine N-methyltransferase EZH1
3.6
68
96
EZH1EZH1Q92800Q92800anatomicalstructuremorphogenesischromatinremodelingheterochromatinformationhippocampusdevelopmenthistoneH3-K27trimethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIsubtelomericheterochromatinformation
Roquin-1
3.9
53
82
RC3H1RC3H1Q4VGL6Q4VGL6"3-UTR-mediatedmRNAdestabilization"Bcellhomeostasiscellularresponsetointerleukin-1lymphnodedevelopmentnegativeregulationofactivatedTcellproliferationnegativeregulationofBcellproliferationnegativeregulationofgerminalcenterformationnegativeregulationofT-helper17celldifferentiationnegativeregulationofT-helpercelldifferentiationnuclear-transcribedmRNAcatabolicprocessnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecayP-bodyassemblypositiveregulationofmRNAcatabolicprocesspositiveregulationofNIK/NF-kappaBsignalingpost-transcriptionalregulationofgeneexpressionproteinpolyubiquitinationregulationofgeneexpressionregulationofgerminalcenterformationregulationofmiRNAmetabolicprocessregulationofmRNAstabilityregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecayregulationofTcellreceptorsignalingpathwayspleendevelopmentTcellhomeostasisTcellproliferationTcellreceptorsignalingpathwayTfollicularhelpercelldifferentiationubiquitin-dependentproteincatabolicprocess
Chromodomain-helicase-DNA-binding protein 4
3.6
49
90
CHD4CHD4Q14839Q14839chromatinremodelingdouble-strandbreakrepairviahomologousrecombinationhistonedeacetylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionregulationofcellfatespecificationregulationofstemcelldifferentiationregulationofsynapseassemblyterminalbuttonorganization
Protrudin
3.5
54
89
ZFY27ZFY27Q5T4F4Q5T4F4endoplasmicreticulumtubularnetworkformationneuronprojectiondevelopmentneurotrophinTRKreceptorsignalingpathwaypositiveregulationofaxonextensionproteinlocalizationtoplasmamembranevesicle-mediatedtransport
Hepatocyte growth factor-regulated tyrosine kinase substrate
3.8
45
87
HGSHGSO14964O14964endocyticrecyclingendosomaltransportmacroautophagymembranefissionmembraneinvaginationmultivesicularbodyassemblynegativeregulationofangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaynegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofexosomalsecretionpositiveregulationofgeneexpressionproteinlocalizationtomembraneproteintargetingtolysosomeproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayreceptorinternalizationregulationofMAPkinaseactivityregulationofproteincatabolicprocesssignaltransduction
Nocturnin
3.5
95
64
NOCTNOCTQ9UK39Q9UK39circadianregulationofgeneexpressiondeadenylation-dependentdecappingofnuclear-transcribedmRNAmRNAstabilizationNADPmetabolicprocessnegativeregulationofgeneexpressionnegativeregulationofosteoblastdifferentiationP-bodyassemblypositiveregulationoffatcelldifferentiationregulationofcircadianrhythmregulationofembryonicdevelopmentresponsetoextracellularstimulusresponsetolipopolysaccharidetranscriptionbyRNApolymeraseII
Zinc finger protein Eos
3.5
35
80
IKZF4IKZF4Q9H2S9Q9H2S9negativeregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIproteinhomooligomerizationregulationoftranscriptionbyRNApolymeraseII
E3 ubiquitin-protein ligase BRE1A
3.8
44
88
BRE1ABRE1AQ5VTR2Q5VTR2chromatinorganizationhistoneH2BconservedC-terminallysineubiquitinationhistoneH2BubiquitinationhistonemonoubiquitinationnegativeregulationofcellmigrationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofhistonemethylationproteinpolyubiquitinationregulationofDNA-templatedtranscriptionubiquitin-dependentproteincatabolicprocess
NAD-dependent protein deacetylase sirtuin-1
3.6
49
87
SIR1SIR1Q96EB6Q96EB6angiogenesisbehavioralresponsetostarvationcellularglucosehomeostasiscellularresponsetoDNAdamagestimuluscellularresponsetoglucosestarvationcellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetoionizingradiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetostarvationcellularresponsetotumornecrosisfactorcellulartriglyceridehomeostasischolesterolhomeostasischromatinorganizationcircadianregulationofgeneexpressionDNAmethylation-dependentheterochromatinformationDNAsynthesisinvolvedinDNArepairenergyhomeostasisfattyacidhomeostasisheterochromatinformationhistonedeacetylationhistoneH3deacetylationintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorleptin-mediatedsignalingpathwaymacrophagedifferentiationmuscleorgandevelopmentnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcAMP-dependentproteinkinaseactivitynegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcellularresponsetotestosteronestimulusnegativeregulationofcellularsenescencenegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofhelicaseactivitynegativeregulationofhistoneH3-K14acetylationnegativeregulationofhistoneH3-K9trimethylationnegativeregulationofhistoneH4-K16acetylationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofneurondeathnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofpeptidyl-lysineacetylationnegativeregulationofphosphorylationnegativeregulationofprostaglandinbiosyntheticprocessnegativeregulationofproteinacetylationnegativeregulationofproteinkinaseBsignalingnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayovulationfromovarianfolliclepeptidyl-lysineacetylationpeptidyl-lysinedeacetylationpositiveregulationofadaptiveimmuneresponsepositiveregulationofadiposetissuedevelopmentpositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcAMP-dependentproteinkinaseactivitypositiveregulationofcellpopulationproliferationpositiveregulationofcellularsenescencepositiveregulationofcholesteroleffluxpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNArepairpositiveregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofendothelialcellproliferationpositiveregulationofgluconeogenesispositiveregulationofhistonedeacetylationpositiveregulationofhistoneH3-K9methylationpositiveregulationofhistonemethylationpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofmacroautophagypositiveregulationofmacrophageapoptoticprocesspositiveregulationofmacrophagecytokineproductionpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeacetylationproteindepropionylationproteindestabilizationproteinubiquitinationpyrimidinedimerrepairbynucleotide-excisionrepairrDNAheterochromatinformationregulationofapoptoticprocessregulationofbileacidbiosyntheticprocessregulationofbrownfatcelldifferentiationregulationofcellpopulationproliferationregulationofcellularresponsetoheatregulationofcentrosomeduplicationregulationofendodeoxyribonucleaseactivityregulationofglucosemetabolicprocessregulationoflipidstorageregulationofmitoticcellcycleregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwayregulationofproteinserine/threoninekinaseactivityregulationofsmoothmusclecellapoptoticprocessregulationoftranscriptionbyglucoseresponsetohydrogenperoxideresponsetoinsulinresponsetoleptinresponsetooxidativestresssinglestrandbreakrepairspermatogenesisstress-inducedprematuresenescencetransforminggrowthfactorbetareceptorsignalingpathwaytriglyceridemobilizationUV-damageexcisionrepairwhitefatcelldifferentiation
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
3.5
79
87
ASAP2ASAP2Q7SIG6Q7SIG6positiveregulationofGTPaseactivity
Histone-lysine N-methyltransferase NSD2
4.0
nan
91
NSD2NSD2O96028O96028atrialseptumprimummorphogenesisatrialseptumsecundummorphogenesisbonedevelopmentchromatinorganizationdouble-strandbreakrepairhistoneH3-K36methylationhistoneH4-K20methylationmembranousseptummorphogenesisnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofisotypeswitchingtoIgAisotypesregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepairvianonhomologousendjoiningregulationofestablishmentofproteinlocalization
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2
3.7
68
95
TAB2TAB2Q9NYJ8Q9NYJ8heartdevelopmentnegativeregulationofautophagypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteinkinaseactivityresponsetolipopolysaccharide
cGMP-dependent 3',5'-cyclic phosphodiesterase
3.5
77
78
PDE2APDE2AO00408O00408adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayaortadevelopmentcAMP-mediatedsignalingcellularresponseto2378-tetrachlorodibenzodioxinecellularresponsetocAMPcellularresponsetocGMPcellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluscellularresponsetomechanicalstimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoxenobioticstimuluscGMPcatabolicprocesscGMP-mediatedsignalingestablishmentofendothelialbarrierheartvalvedevelopmentmonocytedifferentiationnegativeregulationofcAMP-mediatedsignalingnegativeregulationofcGMP-mediatedsignalingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularpermeabilitypositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofvascularpermeabilityregulationofcAMP-mediatedsignalingregulationofcGMP-mediatedsignalingregulationofmitochondrionorganizationsignaltransductionventricularseptumdevelopment
Autophagy-related protein 9A
3.5
47
84
ATG9AATG9AQ7Z3C6Q7Z3C6autophagosomeassemblyautophagyofmitochondrionbonemorphogenesislatenucleophagypositiveregulationofnecroticcelldeathproteinlocalizationtophagophoreassemblysite
N-chimaerin
4.0
37
78
CHINCHINP15882P15882ephrinreceptorsignalingpathwaymotorneuronaxonguidancepositiveregulationofGTPaseactivityregulationofaxonogenesisregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransduction
Liver X nuclear receptor beta
3.6
61
92
F1D8P7F1D8P7F1D8P7F1D8P7lipidmetabolicprocess
CXXC-type zinc finger protein 4
3.5
42
78
CXXC4CXXC4Q9H2H0Q9H2H0negativeregulationofWntsignalingpathwayWntsignalingpathwayzygoticspecificationofdorsal/ventralaxis
Desmoplakin
3.5
63
75
DESPDESPP15924P15924adherensjunctionorganizationbundleofHiscell-Purkinjemyocyteadhesioninvolvedincellcommunicationcell-celladhesiondesmosomeorganizationepidermisdevelopmentepithelialcell-celladhesionintermediatefilamentcytoskeletonorganizationintermediatefilamentorganizationkeratinocytedifferentiationpeptidecross-linkingproteinlocalizationtocell-celljunctionregulationofheartratebycardiacconductionregulationofventricularcardiacmusclecellactionpotentialskindevelopmentventricularcompactmyocardiummorphogenesiswoundhealing
GPI-anchor transamidase
3.5
50
83
GPI8GPI8Q92643Q92643attachmentofGPIanchortoproteinproteolysis
Ligand of Numb protein X 2
3.9
43
89
LNX2LNX2Q8N448Q8N448neuralprecursorcellproliferationneurondifferentiation
Elongation factor-like GTPase 1
3.5
93
71
EFL1EFL1Q7Z2Z2Q7Z2Z2cytosolicribosomeassemblyGTPmetabolicprocess
Thyroid receptor-interacting protein 6
3.3
40
92
TRIP6TRIP6Q15654Q15654chordateembryonicdevelopmentfocaladhesionassemblypositiveregulationofcellmigrationpositiveregulationofNIK/NF-kappaBsignalingsignaltransduction
Methionine aminopeptidase 2
3.5
79
72
✔
MAP2MAP2P50579P50579N-terminalproteinaminoacidmodificationpeptidyl-methioninemodificationproteininitiatormethionineremovalinvolvedinproteinmaturationproteinprocessing
Endothelin-1
3.5
36
80
EDN1EDN1P05305P05305adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayarterysmoothmusclecontractionaxonextensionaxonogenesisinvolvedininnervationbodyfluidsecretionbranchinginvolvedinbloodvesselmorphogenesiscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycardiacneuralcrestcellmigrationinvolvedinoutflowtractmorphogenesiscartilagedevelopmentcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetofattyacidcellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetoglucocorticoidstimuluscellularresponsetohumanchorionicgonadotropinstimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetointerleukin-1cellularresponsetoluteinizinghormonestimuluscellularresponsetomineralocorticoidstimuluscellularresponsetoorganicsubstancecellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferoncellularresponsetoxenobioticstimulusdorsal/ventralpatternformationembryonichearttubedevelopmentendothelinreceptorsignalingpathwayendothelinreceptorsignalingpathwayinvolvedinheartprocessepithelialfluidtransportERK1andERK2cascadeGprotein-coupledreceptorsignalingpathwayhistaminesecretionI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentinositolphosphate-mediatedsignalingleukocyteactivationmaternalprocessinvolvedinparturitionmeioticcellcycleprocessinvolvedinoocytematurationmembranedepolarizationmiddleearmorphogenesismitochondrionorganizationmulticellularorganismagingnegativeregulationofbloodcoagulationnegativeregulationofgeneexpressionnegativeregulationofhormonesecretionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinmetabolicprocessnegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellfatecommitmentnitricoxidetransportnoradrenergicneurondifferentiationpeptidehormonesecretionpharyngealarcharterymorphogenesisphosphatidylinositol3-kinasesignalingphospholipaseD-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcardiacmusclehypertrophypositiveregulationofcationchannelactivitypositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcellsizepositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellmigrationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofJUNkinaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofodontogenesispositiveregulationofprostaglandinsecretionpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofrenalsodiumexcretionpositiveregulationofsarcomereorganizationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostaglandinbiosyntheticprocessproteinkinaseAsignalingproteinkinaseCdeactivationproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofglucosetransmembranetransportregulationofpHregulationofsensoryperceptionofpainregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionrenalsodiumionabsorptionrespiratorygaseousexchangebyrespiratorysystemresponsetoactivityresponsetoaminoacidresponsetoamphetamineresponsetodexamethasoneresponsetoleptinresponsetolipopolysaccharideresponsetomusclestretchresponsetonicotineresponsetoozoneresponsetoprostaglandinFresponsetosaltresponsetotestosteronerhythmicexcitationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesensoryperceptionofpainsuperoxideaniongenerationsympatheticneuronaxonguidancethyroidglanddevelopmenttranscriptionbyRNApolymeraseIIvasoconstrictionveinsmoothmusclecontraction
Zinc finger protein 512
3.9
34
93
ZN512ZN512Q96ME7Q96ME7
CREB-binding protein
3.7
44
91
CBPCBPQ92793Q92793cellularresponsetoUVembryonicdigitmorphogenesishistoneacetylationhomeostaticprocessN-terminalpeptidyl-lysineacetylationnegativeregulationoftranscriptionbyRNApolymeraseInegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinacetylationproteindestabilizationprotein-containingcomplexassemblyregulationofcellularresponsetoheatregulationofDNA-templatedtranscriptionregulationofsmoothenedsignalingpathwayresponsetohypoxiarhythmicprocesssignaltransductionstimulatoryC-typelectinreceptorsignalingpathway
Protein S100-A11
3.5
74
63
✔
S10ABS10ABP31949P31949negativeregulationofcellpopulationproliferationnegativeregulationofDNAreplicationpositiveregulationofsmoothmusclecellmigrationsignaltransduction
TAP binding protein-like variant
3.5
82
72
Q53GH5Q53GH5Q53GH5Q53GH5
UMP-CMP kinase
3.5
58
75
KCYKCYP30085P30085"denovopyrimidinenucleobasebiosyntheticprocess"CDPbiosyntheticprocessnucleobase-containingsmallmoleculeinterconversionnucleosidediphosphatephosphorylationnucleosidetriphosphatebiosyntheticprocesspyrimidineribonucleotidebiosyntheticprocessUDPbiosyntheticprocess
DNA-directed RNA polymerase I subunit RPA1
3.5
62
82
RPA1RPA1O95602O95602negativeregulationofproteinlocalizationtonucleolus
Transcriptional regulator ATRX
3.6
48
86
ATRXATRXP46100P46100cellularresponsetohydroxyureachromatinorganizationchromatinremodelingchromosomeorganizationinvolvedinmeioticcellcycleDNAdamageresponsesignaltransductionbyp53classmediatorDNAmethylationDNArepairforebraindevelopmentmeioticspindleorganizationmulticellularorganismgrowthnegativeregulationofmaintenanceofmitoticsisterchromatidcohesiontelomericnucleosomeassemblypositiveregulationofnuclearcellcycleDNAreplicationpositiveregulationoftelomeremaintenancepositiveregulationoftelomericRNAtranscriptionfromRNApolIIpromoterpositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicforelimbmorphogenesisproteinlocalizationtochromosometelomericregionregulationofDNA-templatedtranscriptionreplicationforkprocessingseminiferoustubuledevelopmentSertolicelldevelopmentspermatogenesissubtelomericheterochromatinformationtranscriptionbyRNApolymeraseII
Ski oncogene
3.5
54
94
SKISKIP12755P12755anterior/posterioraxisspecificationbonemorphogenesiscamera-typeeyedevelopmentcamera-typeeyemorphogenesiscardiacmusclecellproliferationcellmotilityembryoniclimbmorphogenesisfacemorphogenesislensmorphogenesisincamera-typeeyemyelinationinperipheralnervoussystemmyotubedifferentiationnegativeregulationofactivinreceptorsignalingpathwaynegativeregulationofBMPsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastproliferationnegativeregulationofosteoblastdifferentiationnegativeregulationofSchwanncellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayneuraltubeclosurenosemorphogenesisolfactorybulbdevelopmentpositiveregulationofDNAbindingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofWntsignalingpathwayretinadevelopmentincamera-typeeyeroofofmouthdevelopmentskeletalmusclefiberdevelopmentSMADproteinsignaltransductionsomaticstemcellpopulationmaintenancetransforminggrowthfactorbetareceptorsignalingpathway
AN1-type zinc finger protein 3
3.5
55
86
ZFAN3ZFAN3Q9H8U3Q9H8U3
Fermitin family homolog 3
3.5
70
80
URP2URP2Q86UX7Q86UX7cell-matrixadhesionintegrinactivationintegrin-mediatedsignalingpathwayleukocytecell-celladhesionplateletaggregationpositiveregulationofcellmigrationregulationofcell-celladhesionmediatedbyintegrinsubstrateadhesion-dependentcellspreading
Prestin
4.2
39
73
S26A5S26A5Q9JKQ2Q9JKQ2regulationofcellshapesensoryperceptionofsound
WD repeat-containing protein 19
3.5
64
90
WDR19WDR19Q8NEZ3Q8NEZ3cellmorphogenesisciliaryreceptorclusteringinvolvedinsmoothenedsignalingpathwayciliumassemblydigestivesystemdevelopmentearmorphogenesisembryoniccamera-typeeyedevelopmentembryoniccranialskeletonmorphogenesisembryoniclimbmorphogenesisgonaddevelopmentinuteroembryonicdevelopmentintraciliaryretrogradetransportmyotomedevelopmentnervoussystemprocessproteinlocalizationtociliarymembraneprotein-containingcomplexassemblysmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterning
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
3.8
63
89
TAB3TAB3Q571K4Q571K4positiveregulationofI-kappaBkinase/NF-kappaBsignaling
DNA-directed RNA polymerase III subunit RPC3
3.5
71
75
RPC3RPC3Q9BUI4Q9BUI4defenseresponsetovirusDNA-templatedtranscriptioninnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductionregulationoftranscriptionbyRNApolymeraseIII
Ankyrin repeat domain-containing protein 27
3.5
36
84
ANR27ANR27Q96NW4Q96NW4earlyendosometolateendosometransportendocyticrecyclingendosometomelanosometransportnegativeregulationofSNAREcomplexassemblyneuronprojectionmorphogenesispositiveregulationofdendritemorphogenesispositiveregulationofneuronprojectiondevelopmentproteintransport
Pyrroline-5-carboxylate reductase 2
3.5
77
81
P5CR2P5CR2Q96C36Q96C36cellularresponsetooxidativestressL-prolinebiosyntheticprocessprolinebiosyntheticprocess
E3 SUMO-protein ligase PIAS3
3.8
60
78
PIAS3PIAS3Q9Y6X2Q9Y6X2negativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationnegativeregulationofproteinsumoylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressionpositiveregulationofmembranepotentialpositiveregulationofproteinsumoylationproteinsumoylationregulationoftranscriptionbyRNApolymeraseIIresponsetohormoneTNFSF11-mediatedsignalingpathway
NAD(+) hydrolase SARM1
3.5
68
74
SARM1SARM1Q6SZW1Q6SZW1celldifferentiationinnateimmuneresponseNADcatabolicprocessnegativeregulationofMyD88-independenttoll-likereceptorsignalingpathwaynervoussystemdevelopmentpositiveregulationofneurondeathregulationofdendritemorphogenesisregulationofneuronapoptoticprocessregulationofneurondeathresponsetoaxoninjuryresponsetoglucosesignaltransduction
E3 ubiquitin-protein ligase TRIM37
3.8
nan
96
TRI37TRI37O94972O94972aggresomeassemblyhistoneH2AmonoubiquitinationhistoneH2A-K119monoubiquitinationnegativeregulationofcentriolereplicationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofNF-kappaBtranscriptionfactoractivityproteinautoubiquitinationproteinimportintoperoxisomematrix
E3 ubiquitin-protein ligase FANCL
3.5
54
88
FANCLFANCLQ9NW38Q9NW38cellularresponsetoDNAdamagestimulusDNArepairgametegenerationinterstrandcross-linkrepairproteinmonoubiquitinationregulationofcellpopulationproliferation
E3 ubiquitin-protein ligase RNF168
3.7
34
87
RN168RN168Q8IYW5Q8IYW5cellularresponsetoDNAdamagestimuluschromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkedubiquitinationhistoneH2AmonoubiquitinationhistoneH2A-K13ubiquitinationhistoneH2A-K15ubiquitinationinterstrandcross-linkrepairisotypeswitchingnegativeregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationofDNArepairproteinK63-linkedubiquitinationproteinubiquitinationresponsetoionizingradiationubiquitin-dependentproteincatabolicprocess
Fanconi anemia, complementation group I
3.6
70
75
B7ZMF2B7ZMF2B7ZMF2B7ZMF2DNArepair
Mineralocorticoid receptor
3.5
66
85
MCRMCRP08235P08235intracellularsteroidhormonereceptorsignalingpathwaypositiveregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
DNA-directed RNA polymerase subunit beta
3.5
71
70
A0A0B8RVL1A0A0B8RVL1A0A0B8RVL1A0A0B8RVL1DNA-templatedtranscription
E3 ubiquitin-protein ligase Mdm2
3.8
43
89
MDM2MDM2Q00987Q00987amyloidfibrilformationapoptoticprocessatrialseptumdevelopmentatrioventricularvalvemorphogenesisbloodvesseldevelopmentbloodvesselremodelingcardiacseptummorphogenesiscellularresponsetoactinomycinDcellularresponsetogammaradiationcellularresponsetohypoxiaDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestendocardialcushionmorphogenesisestablishmentofproteinlocalizationlocalizationnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofDNA-templatedtranscriptionnegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofsignaltransductionbyp53classmediatornegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellpopulationproliferationpositiveregulationofmitoticcellcyclepositiveregulationofmusclecelldifferentiationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteindestabilizationproteinlocalizationtonucleusproteinpolyubiquitinationproteinsumoylationproteinubiquitinationprotein-containingcomplexassemblyproteolysisinvolvedinproteincatabolicprocessregulationofcellcycleregulationofheartrateregulationofproteincatabolicprocessregulationoftranscriptionbyRNApolymeraseIIresponsetoantibiotictranscriptionfactorcatabolicprocesstraversingstartcontrolpointofmitoticcellcycleubiquitin-dependentproteincatabolicprocessventricularseptumdevelopment
AN1-type zinc finger protein 2B
3.5
49
91
ZFN2BZFN2BQ8WV99Q8WV99proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteintargetingtoERregulationofinsulin-likegrowthfactorreceptorsignalingpathwaySRP-dependentcotranslationalproteintargetingtomembranetranslocation
ATP-dependent DNA helicase
3.5
69
84
A0JN36A0JN36A0JN36A0JN36DNAduplexunwindingDNArecombinationDNArepairDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviahomologousrecombination
Ubiquitin-40S ribosomal protein S27a
3.5
47
86
Q5RKT7Q5RKT7Q5RKT7Q5RKT7translation
E3 ubiquitin/ISG15 ligase TRIM25
3.5
70
91
TRI25TRI25Q14258Q14258cellularresponsetoleukemiainhibitoryfactorinnateimmuneresponsenegativeregulationofviralentryintohostcellpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinmonoubiquitinationregulationofproteinlocalizationregulationofviralentryintohostcellresponsetoestrogenresponsetovitaminDsuppressionofviralreleasebyhostubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocessviralreleasefromhostcell
Nuclear receptor subfamily 4 group A member 2
4.0
47
88
F1D8N6F1D8N6F1D8N6F1D8N6adultlocomotorybehaviorcellularresponsetocorticotropin-releasinghormonestimuluscellularresponsetoextracellularstimuluscellularresponsetooxidativestresscentralnervoussystemprojectionneuronaxonogenesisdopaminebiosyntheticprocessdopaminergicneurondifferentiationfatcelldifferentiationgeneraladaptationsyndromehabenuladevelopmentnegativeregulationofneuronapoptoticprocessneuronapoptoticprocessneuronmaturationneuronmigrationpositiveregulationofcatalyticactivitypost-embryonicdevelopmentregulationofdopaminemetabolicprocessregulationofrespiratorygaseousexchangeresponsetoamphetamineresponsetohypoxiatranscriptionbyRNApolymeraseII
Inhibitor of nuclear factor kappa-B kinase subunit beta
3.5
78
75
IKKBIKKBO14920O14920antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassITAP-dependentcellularresponsetotumornecrosisfactorcorticalactincytoskeletonorganizationFc-epsilonreceptorsignalingpathwayI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseinterleukin-1-mediatedsignalingpathwaynegativeregulationofbicellulartightjunctionassemblynegativeregulationofmyosin-light-chain-phosphataseactivitypeptidyl-serinephosphorylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofestablishmentofendothelialbarrierregulationofphosphorylationregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetovirusstimulatoryC-typelectinreceptorsignalingpathwaystress-activatedMAPKcascadeTcellreceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathway
Gamma-butyrobetaine dioxygenase
3.5
51
79
BODGBODGO75936O75936carnitinebiosyntheticprocess
Coiled-coil domain-containing protein 25
3.5
56
78
CCD25CCD25Q86WR0Q86WR0positiveregulationofcellmotility
Cell cycle checkpoint protein RAD1
3.9
63
79
RAD1RAD1O60671O60671cellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationDNAdamagecheckpointsignalingDNArepairmeioticrecombinationcheckpointsignalingsubstantianigradevelopment
Nuclear factor of activated T-cells 5
3.5
64
76
NFAT5NFAT5O94916O94916calcineurin-NFATsignalingcascadecellularhyperosmoticresponsecellularresponsetocytokinestimuluscellularresponsetoDNAdamagestimuluspositiveregulationofgeneexpressionpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIR-loopprocessingregulationofcalcineurin-NFATsignalingcascaderegulationoftranscriptionbyRNApolymeraseIIsignaltransductiontranscriptionbyRNApolymeraseII
Scinderin
3.5
71
75
SCINSCINQ9Y6U3Q9Y6U3actinfilamentcappingactinfilamentseveringactinnucleationactinpolymerizationordepolymerizationbarbed-endactinfilamentcappingcalcium-ionregulatedexocytosiscellprojectionassemblycentralnervoussystemdevelopmentnegativeregulationofcellpopulationproliferationpositiveregulationofactinnucleationpositiveregulationofapoptoticprocesspositiveregulationofmegakaryocytedifferentiationpositiveregulationofsecretionregulationofchondrocytedifferentiationsequesteringofactinmonomers
Diacylglycerol kinase delta
3.5
47
89
DGKDDGKDQ16760Q16760diacylglycerolmetabolicprocessendocytosisepidermalgrowthfactorreceptorsignalingpathwayintracellularsignaltransductionlipidphosphorylationnegativeregulationofproteinkinaseCsignalingphosphatidicacidbiosyntheticprocessplateletactivationpositiveregulationofclathrin-dependentendocytosispositiveregulationofepidermalgrowthfactorreceptorsignalingpathwayproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayproteintransportresponsetoorganicsubstancesignaltransduction
Ubiquitin carboxyl-terminal hydrolase CYLD
4.0
45
84
CYLDCYLDQ9NQC7Q9NQC7cellcycleinnateimmuneresponsenecroptoticprocessnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-18-mediatedsignalingpathwaynegativeregulationofJNKcascadenegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofp38MAPKcascadenegativeregulationoftypeIinterferonproductionnucleotide-bindingoligomerizationdomaincontainingsignalingpathwaypositiveregulationofextrinsicapoptoticsignalingpathwayproteindeubiquitinationproteinK63-linkeddeubiquitinationproteinlineardeubiquitinationregulationofciliumassemblyregulationofinflammatoryresponseregulationofintrinsicapoptoticsignalingpathwayregulationofmicrotubulecytoskeletonorganizationregulationofmitoticcellcycleregulationofnecroptoticprocessregulationoftumornecrosisfactor-mediatedsignalingpathwayubiquitin-dependentproteincatabolicprocessWntsignalingpathway
Protein disulfide-isomerase A4
3.5
46
86
✔
PDIA4PDIA4P13667P13667chaperone-mediatedproteinfoldingproteinfoldingproteinsecretionresponsetoendoplasmicreticulumstress
Tetratricopeptide repeat protein 4
3.5
63
74
TTC4TTC4O95801O95801defenseresponsetovirusinnateimmuneresponseproteinfolding
E3 ubiquitin-protein ligase RLIM
3.5
57
82
RNF12RNF12Q9NVW2Q9NVW2negativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIproteinubiquitinationrandominactivationofXchromosomeregulationofdosagecompensationbyinactivationofXchromosomeubiquitin-dependentproteincatabolicprocess
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
4.4
77
79
SDHBSDHBQ007T0Q007T0tricarboxylicacidcycle
AH receptor-interacting protein
3.5
78
77
AIPAIPO08915O08915negativeregulationofcyclic-nucleotidephosphodiesteraseactivityproteinmaturationbyproteinfoldingproteintargetingtomitochondrionregulationofproteinkinaseAsignalingxenobioticmetabolicprocess
INO80 complex subunit B
3.6
49
86
IN80BIN80BQ9C086Q9C086chromatinremodelingDNArecombinationDNArepairpositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftelomeremaintenanceinresponsetoDNAdamageregulationofcellcycleregulationofchromosomeorganizationregulationofDNArepairregulationofDNAreplicationregulationofDNAstrandelongationregulationofembryonicdevelopmenttelomeremaintenance
DNA-directed RNA polymerase I subunit RPA2
3.6
56
84
RPA2RPA2Q9H9Y6Q9H9Y6embryoimplantationneuralcrestformationnucleologenesisrRNAtranscription
Myomesin-1
3.5
63
78
MYOM1MYOM1Q62234Q62234musclecontractionpositiveregulationofgeneexpressionpositiveregulationofproteinsecretionproteinkinaseAsignaling
Aquaporin-2
3.5
66
78
AQP2AQP2P41181P41181cellularresponsetocopperioncellularresponsetomercuryioncellularresponsetowaterdeprivationglyceroltransmembranetransportmetanephriccollectingductdevelopmentproteinhomotetramerizationrenalwaterhomeostasisrenalwatertransportwatertransport
Lethal(3)malignant brain tumor-like protein 2
4.0
51
89
LMBL2LMBL2Q969R5Q969R5chromatinorganizationnegativeregulationofDNA-templatedtranscription
WD repeat-containing and planar cell polarity effector protein fritz homolog
4.6
54
71
FRITZFRITZO95876O95876auditoryreceptorcellmorphogenesiscamera-typeeyedevelopmentciliumassemblyciliumorganizationcirculatorysystemdevelopmentdigestivesystemdevelopmentembryonicdigitmorphogenesisestablishmentofplanarpolarityestablishmentofproteinlocalizationintraciliarytransportkidneydevelopmentnervoussystemdevelopmentneuraltubedevelopmentpodocytecellmigrationregulationofciliumassemblyregulationofembryoniccellshaperegulationofestablishmentofcellpolarityregulationoffibroblastmigrationregulationoffocaladhesionassemblyregulationofproteinlocalizationregulationofruffleassemblyrespiratorysystemdevelopmentroofofmouthdevelopmentseptincytoskeletonorganizationsmoothenedsignalingpathwaytonguemorphogenesis
WD repeat-containing protein 35
3.8
70
79
WDR35WDR35Q9P2L0Q9P2L0cellularresponsetoleukemiainhibitoryfactorciliumassemblyintraciliaryretrogradetransportintraciliarytransportproteinlocalizationtocilium
ATPase MORC2
3.6
66
86
✔
MORC2MORC2Q9Y6X9Q9Y6X9cellularresponsetoDNAdamagestimuluschromatinremodelingfattyacidmetabolicprocessnegativeregulationofgeneexpressionepigeneticnegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatepositiveregulationofDNAmethylation-dependentheterochromatinformation
Transcription factor HES-1
4.2
54
81
HES1HES1Q14469Q14469adenohypophysisdevelopmentamacrinecelldifferentiationanterior/posteriorpatternspecificationarterymorphogenesisascendingaortamorphogenesisBMPsignalingpathwayCajal-Retziuscelldifferentiationcardiacneuralcrestcelldevelopmentinvolvedinoutflowtractmorphogenesiscelladhesioncellfatedeterminationcellmaturationcellmigrationcellmorphogenesisinvolvedinneurondifferentiationcellularresponsetofattyacidcellularresponsetointerleukin-1cellularresponsetonervegrowthfactorstimuluscellularresponsetotumornecrosisfactorcochleadevelopmentcomma-shapedbodymorphogenesiscommonbileductdevelopmentembryonichearttubemorphogenesisestablishmentofepithelialcellpolarityforebrainradialglialcelldifferentiationglomerulusvasculaturedevelopmenthindbrainmorphogenesisinnerearauditoryreceptorcelldifferentiationinnerearreceptorcellstereociliumorganizationlabyrinthinelayerbloodvesseldevelopmentlateralinhibitionliverdevelopmentlungdevelopmentmetanephricnephrontubulemorphogenesismidbraindevelopmentmidbrain-hindbrainboundarymorphogenesisnegativeregulationofamacrinecelldifferentiationnegativeregulationofcalciumionimportnegativeregulationofcellfatedeterminationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofforebrainneurondifferentiationnegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofinnerearauditoryreceptorcelldifferentiationnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoligodendrocytedifferentiationnegativeregulationofpancreaticAcelldifferentiationnegativeregulationofpro-BcelldifferentiationnegativeregulationofstemcelldifferentiationnegativeregulationofstomachneuroendocrinecelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuronalstemcellpopulationmaintenanceNotchsignalingpathwayoculomotornervedevelopmentoutflowtractmorphogenesispancreaticAcelldifferentiationpharyngealarcharterymorphogenesispositiveregulationofastrocytedifferentiationpositiveregulationofBMPsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofgeneexpressionpositiveregulationofmitoticcellcycleembryonicpositiveregulationofNotchsignalingpathwaypositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftyrosinephosphorylationofSTATproteinprotein-containingcomplexassemblyregulationofepithelialcellproliferationregulationoffatcelldifferentiationregulationofneurogenesisregulationofprotein-containingcomplexassemblyregulationofreceptorsignalingpathwayviaJAK-STATregulationofsecondaryheartfieldcardioblastproliferationregulationoftimingofneurondifferentiationregulationoftranscriptionbyRNApolymeraseIIrenalinterstitialfibroblastdevelopmentresponsetoalkaloidresponsetoorganiccycliccompoundresponsetothyroidhormoneS-shapedbodymorphogenesissmoothenedsignalingpathwaysomaticstemcellpopulationmaintenancestomachneuroendocrinecelldifferentiationTcellproliferationtelencephalondevelopmentthymusdevelopmenttrochlearnervedevelopmenturetericbudmorphogenesisvascularassociatedsmoothmusclecelldevelopmentventricularseptumdevelopmentventricularseptummorphogenesis
CDGSH iron-sulfur domain-containing protein 1
3.5
84
74
CISD1CISD1Q1X902Q1X902proteinmaturationby2Fe-2Sclustertransferregulationofautophagyregulationofcellularrespiration
Progesterone receptor
3.8
72
85
PRGRPRGRP06401P06401cell-cellsignalingglandularepithelialcellmaturationintracellularsteroidhormonereceptorsignalingpathwaylungalveolusdevelopmentnegativeregulationofgeneexpressionovulationfromovarianfollicleparacrinesignalingpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayregulationofepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIIsignaltransductiontertiarybranchinginvolvedinmammaryglandductmorphogenesis
Transportin-3
3.5
78
74
✔
TNPO3TNPO3Q9Y5L0Q9Y5L0proteinimportintonucleus
Ketohexokinase
3.8
88
67
KHKKHKP50053P50053fructosemetabolicprocessregulationofglycogenmetabolicprocessresponsetofructoseresponsetoglucoseresponsetoinsulinresponsetosucroseresponsetozincion
Thyroid hormone receptor beta
3.6
48
88
THBTHBP18113P18113animalorganmorphogenesiscelldifferentiationcellularresponsetothyroidhormonestimulusembryonicorgandevelopmentfemalecourtshipbehaviorhormone-mediatedsignalingpathwaymRNAtranscriptionbyRNApolymeraseIInegativeregulationofDNA-templatedtranscriptionnegativeregulationoffemalereceptivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellpopulationproliferationpositiveregulationofchondrocytedifferentiationpositiveregulationofossificationpositiveregulationofthyroidhormonemediatedsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcholesterolmetabolicprocessregulationofheartcontractionregulationoflipidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftriglyceridemetabolicprocessretinalconecellapoptoticprocessretinalconecelldevelopmentsensoryperceptionofsoundthyroidhormonemediatedsignalingpathwaytypeIpneumocytedifferentiation
Ubiquitin-conjugating enzyme E2 D1
3.5
73
75
UB2D1UB2D1P51668P51668negativeregulationofBMPsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofproteinpolyubiquitinationpositiveregulationofproteinubiquitinationproteinK48-linkedubiquitinationproteinpolyubiquitinationubiquitin-dependentproteincatabolicprocess
Nesprin-2
3.5
71
76
SYNE2SYNE2Q8WXH0Q8WXH0centrosomelocalizationnuclearmigrationnuclearmigrationalongmicrofilamentnucleokinesisinvolvedincellmotilityincerebralcortexradialgliaguidedmigrationpositiveregulationofcellmigrationregulationofciliumassembly
Clathrin heavy chain 1
3.5
79
74
✔
CLH1CLH1P49951P49951amyloid-betaclearancebytranscytosisautophagycelldivisionclathrincoatassemblyclathrin-dependentendocytosisintracellularproteintransportmitoticcellcyclenegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofproteinlocalizationtoplasmamembranereceptorinternalizationreceptor-mediatedendocytosisregulationofmitoticspindleorganizationretrogradetransportendosometoGolgitransferrintransport
E3 ubiquitin-protein ligase RNF113A
3.5
67
90
R113AR113AO15541O15541DNArepairisopeptidecross-linkingviaN6-glycyl-L-lysinemRNAsplicingviaspliceosomenegativeregulationofchemokine-mediatedsignalingpathwayproteinubiquitinationsnoRNAsplicing
V(D)J recombination-activating protein 1
3.5
64
91
RAG1RAG1P15919P15919adaptiveimmuneresponseBcelldifferentiationchromatinorganizationDNArecombinationhistonemonoubiquitinationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTcellapoptoticprocessnegativeregulationofthymocyteapoptoticprocesspositiveregulationofTcelldifferentiationpre-BcellallelicexclusionproteinautoubiquitinationregulationofbehavioralfearresponseregulationofTcelldifferentiationTcelldifferentiationinthymusTcellhomeostasisthymusdevelopmentV(D)Jrecombinationvisuallearning
Proline-, glutamic acid- and leucine-rich protein 1
3.5
79
70
C9JFV4C9JFV4C9JFV4C9JFV4
28S ribosomal protein S16, mitochondrial
3.5
49
90
✔
RT16RT25Q9Y3D3P82663mitochondrialtranslationtranslation
Zinc finger MYND domain-containing protein 11
4.1
50
88
ZMY11ZMY11Q15326Q15326cellcyclechromatinorganizationdefenseresponsetovirusnegativeregulationofDNA-templatedtranscriptionnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofJNKcascaderegulationofsignaltransductionregulationoftranscriptionelongationbyRNApolymeraseII
Transcription elongation factor 1 homolog
3.6
58
90
ELOF1ELOF1P60003P60003transcriptionelongationbyRNApolymeraseIIpromoter
Tripartite motif-containing protein 5
3.7
61
89
TRIM5TRIM5Q0PF16Q0PF16activationofinnateimmuneresponseautophagydefenseresponsetovirusinnateimmuneresponsenegativeregulationofviralentryintohostcellnegativeregulationofviralgenomereplicationnegativeregulationofviraltranscriptionpositiveregulationofautophagypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivityproteinK63-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofgeneexpressionregulationoflipopolysaccharide-mediatedsignalingpathwayregulationofproteinlocalizationregulationofviralentryintohostcellsuppressionofviralreleasebyhost
IG c335_light_IGLV1-40_IGLJ3
3.6
90
73
A0A5C2GQT9A0A5C2GQT9A0A5C2GQT9A0A5C2GQT9
DNA-directed RNA polymerase III subunit RPC10
3.6
33
87
RPC10RPC10Q9Y2Y1Q9Y2Y1defenseresponsetovirusinnateimmuneresponseterminationofRNApolymeraseIIItranscriptiontranscriptionbyRNApolymeraseIII"tRNA3-trailercleavage"
Queuine tRNA-ribosyltransferase accessory subunit 2
3.8
65
92
QTRT2QTRT2Q9H974Q9H974tRNA-guaninetransglycosylation
Sodium/potassium-transporting ATPase subunit alpha-3
3.6
76
77
AT1A3AT1A3P13637P13637cellcommunicationbyelectricalcouplinginvolvedincardiacconductioncellularpotassiumionhomeostasiscellularresponsetoamyloid-betacellularresponsetoretinoicacidcellularresponsetosteroidhormonestimuluscellularresponsetothyroidhormonestimuluscellularsodiumionhomeostasiscerebralcortexdevelopmentneuronprojectionmaintenancepotassiumionimportacrossplasmamembraneprotontransmembranetransportregulationofrestingmembranepotentialresponsetoglycosidesodiumionexportacrossplasmamembrane
Obscurin
4.0
75
75
OBSCNOBSCNQ5VST9Q5VST9cell-celladhesionproteinlocalizationtoM-bandproteinphosphorylationregulationofsmallGTPasemediatedsignaltransductionsarcomereorganization
Baculoviral IAP repeat-containing protein 7
4.0
66
88
BIRC7BIRC7Q96CA5Q96CA5lensdevelopmentincamera-typeeyenegativeregulationofapoptoticprocessnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaypositiveregulationofJNKcascadepositiveregulationofproteinubiquitinationproteinubiquitinationregulationofapoptoticprocessregulationofcellcycleregulationofcellpopulationproliferationregulationofnaturalkillercellapoptoticprocess
Lysine-specific demethylase 2B
3.7
39
78
KDM2BKDM2BQ8NHM5Q8NHM5chromatinremodelingembryoniccamera-typeeyemorphogenesisforebraindevelopmentfourthventricledevelopmenthindbraindevelopmenthistoneH3-K36demethylationinitiationofneuraltubeclosurelateralventricledevelopmentmidbraindevelopmentmidbrain-hindbrainboundarymorphogenesisnegativeregulationofneuralprecursorcellproliferationnegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthpositiveregulationofstemcellpopulationmaintenanceproteindemethylationregulationoftranscriptionbyRNApolymeraseIIspermatogenesisthirdventricledevelopment
Zinc finger MYM-type protein 5
3.8
52
90
ZMYM5ZMYM5Q9UJ78Q9UJ78negativeregulationoftranscriptionbyRNApolymeraseII
SH3 and cysteine-rich domain-containing protein 3
3.9
48
90
STAC3STAC3Q96MF2Q96MF2neuromuscularsynaptictransmissionpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofvoltage-gatedcalciumchannelactivityskeletalmusclecontractionskeletalmusclefiberdevelopment
Core histone macro-H2A.2
3.6
85
70
✔
H2AWH2AWQ9P0M6Q9P0M6braindevelopmentdosagecompensationestablishmentofproteinlocalizationtochromatinnegativeregulationofgeneexpressionepigeneticnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseInucleosomeassemblypositiveregulationofkeratinocytedifferentiation
Neurofibromin
3.6
77
74
NF1NF1P21359P21359actincytoskeletonorganizationadrenalglanddevelopmentamygdaladevelopmentangiogenesisarterymorphogenesisbraindevelopmentcamera-typeeyemorphogenesiscellcommunicationcellularresponsetoheatcerebralcortexdevelopmentcognitioncollagenfibrilorganizationendothelialcellproliferationextracellularmatrixorganizationextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsfibroblastproliferationforebrainastrocytedevelopmentforebrainmorphogenesisgamma-aminobutyricacidsecretionneurotransmissionglutamatesecretionneurotransmissionhairfolliclematurationheartdevelopmentliverdevelopmentMAPKcascademastcellapoptoticprocessmastcellproliferationmetanephrosdevelopmentmyelinationinperipheralnervoussystemmyeloidleukocytemigrationnegativeregulationofangiogenesisnegativeregulationofastrocytedifferentiationnegativeregulationofcellmigrationnegativeregulationofcell-matrixadhesionnegativeregulationofendothelialcellproliferationnegativeregulationoffibroblastproliferationnegativeregulationofleukocytemigrationnegativeregulationofMAPkinaseactivitynegativeregulationofMAPKcascadenegativeregulationofmastcellproliferationnegativeregulationofneuroblastproliferationnegativeregulationofneurotransmittersecretionnegativeregulationofoligodendrocytedifferentiationnegativeregulationofosteoclastdifferentiationnegativeregulationofproteinimportintonucleusnegativeregulationofproteinkinaseactivitynegativeregulationofRacproteinsignaltransductionnegativeregulationofSchwanncellmigrationnegativeregulationofSchwanncellproliferationnegativeregulationofstemcellproliferationnegativeregulationofvascularassociatedsmoothmusclecellmigrationneuraltubedevelopmentneuroblastproliferationneuronapoptoticprocessobservationallearningoligodendrocytedifferentiationosteoblastdifferentiationosteoclastdifferentiationperipheralnervoussystemdevelopmentphosphatidylinositol3-kinasesignalingpigmentationpositiveregulationofadenylatecyclaseactivitypositiveregulationofapoptoticprocesspositiveregulationofendothelialcellproliferationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationofGTPaseactivitypositiveregulationofmastcellapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinimportintonucleusRacproteinsignaltransductionRasproteinsignaltransductionregulationofangiogenesisregulationofbloodvesselendothelialcellmigrationregulationofboneresorptionregulationofcell-matrixadhesionregulationofgeneexpressionregulationofglialcelldifferentiationregulationofGTPaseactivityregulationoflong-termneuronalsynapticplasticityregulationoflong-termsynapticpotentiationregulationofpostsynapseorganizationregulationofsynaptictransmissionGABAergicresponsetohypoxiaSchwanncelldevelopmentSchwanncellmigrationSchwanncellproliferationskeletalmuscletissuedevelopmentsmoothmuscletissuedevelopmentspinalcorddevelopmentstemcellproliferationsympatheticnervoussystemdevelopmentvascularassociatedsmoothmusclecellmigrationvascularassociatedsmoothmusclecellproliferationvisuallearningwoundhealing
Protein kinase C alpha type
3.9
49
91
KPCAKPCAP17252P17252angiogenesisapoptoticsignalingpathwaycelladhesiondesmosomeassemblyintracellularsignaltransductionmitoticnuclearmembranedisassemblynegativeregulationofglialcellapoptoticprocesspeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofboneresorptionpositiveregulationofcardiacmusclehypertrophypositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofdensecoregranulebiogenesispositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofmacrophagedifferentiationpositiveregulationofmitoticcellcyclepost-translationalproteinmodificationproteinphosphorylationregulationofmRNAstabilityregulationofplateletaggregationresponsetointerleukin-1
histone acetyltransferase
4.0
44
88
Q7Z6C1Q7Z6C1Q7Z6C1Q7Z6C1histoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseII
Ubiquitin carboxyl-terminal hydrolase 30
3.6
53
88
✔
UBP30UBP30Q70CQ3Q70CQ3autophagyofmitochondrionmitochondrialfusionnegativeregulationofmitophagypexophagyproteindeubiquitinationproteinK11-linkeddeubiquitinationproteinK6-linkeddeubiquitinationubiquitin-dependentproteincatabolicprocess
Transcription elongation factor SPT4
3.9
73
76
✔
SPT4HSPT4HP63272P63272chromatinorganizationnegativeregulationofDNA-templatedtranscriptionelongationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionelongationbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoter
F-box only protein 43
3.6
35
92
FBX43FBX43Q8CDI2Q8CDI2meioticnucleardivisionnegativeregulationofcellcycleprocessnegativeregulationofmeioticnucleardivisionnegativeregulationofproteincatabolicprocessproteincatabolicprocessproteinubiquitinationregulationofmeioticnucleardivisionregulationofmitoticnucleardivision
Nuclear pore complex protein Nup153
3.8
50
93
NU153NU153P49790P49790mRNAtransportnegativeregulationofRNAexportfromnucleusnuclearporecomplexassemblynucleocytoplasmictransportproteinimportintonucleusRNAexportfromnucleusviralentryintohostcellviralpenetrationintohostnucleus
F-box/WD repeat-containing protein 1A
3.6
64
77
FBW1AFBW1AQ9Y297Q9Y297branchinginvolvedinmammaryglandductmorphogenesiscellularresponsetoorganiccycliccompoundmammaryglandepithelialcellproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofsmoothenedsignalingpathwaypositiveregulationofcircadianrhythmpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteolysispositiveregulationofubiquitinproteinligaseactivityproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindephosphorylationproteindestabilizationproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofcanonicalWntsignalingpathwayregulationofcellcycleregulationofcircadianrhythmregulationofI-kappaBkinase/NF-kappaBsignalingregulationofproteasomalproteincatabolicprocessrhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocesssignaltransductionubiquitin-dependentproteincatabolicprocessWntsignalingpathway
Histone-lysine N-methyltransferase KMT5B
3.8
55
86
KMT5BKMT5BQ3U8K7Q3U8K7chromatinorganizationDNArepairhistoneH4-K20dimethylationhistoneH4-K20trimethylationmuscleorgandevelopmentpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationofisotypeswitching
Actin-binding LIM protein 3
3.6
46
87
ABLM3ABLM3O94929O94929ciliumassemblycytoskeletonorganizationlamellipodiumassemblypositiveregulationofproteintargetingtomitochondrionpositiveregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
COUP transcription factor 1
3.6
66
91
COT1COT1P10589P10589anatomicalstructuredevelopmentcelldifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Histone demethylase UTY
3.6
51
87
UTYUTYO14607O14607chromatinorganizationheartdevelopmenthistoneH3-K27demethylationregulationofgeneexpression
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
3.6
80
72
PCKGCPCKGCP35558P35558cellularresponsetodexamethasonestimuluscellularresponsetoglucosestimuluscellularresponsetoinsulinstimuluscellularresponsetopotassiumionstarvationgluconeogenesisglucosehomeostasisglucosemetabolicprocessglycerolbiosyntheticprocessfrompyruvatehepatocytedifferentiationoxaloacetatemetabolicprocesspeptidyl-serinephosphorylationpositiveregulationofmemoryTcelldifferentiationpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoacidicpHpropionatecatabolicprocessregulationoflipidbiosyntheticprocessresponsetobacteriumresponsetoinsulinresponsetolipidresponsetostarvation
Pygopus homolog 1
3.6
44
89
PYGO1PYGO1Q9Y3Y4Q9Y3Y4canonicalWntsignalingpathwayhematopoieticprogenitorcelldifferentiationkidneydevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtonucleusspermatidnucleusdifferentiation
DNA ligase 3
3.6
44
85
DNLI3DNLI3P49916P49916base-excisionrepairDNAligationbase-excisionrepairgap-fillingcellcyclecelldivisionDNAbiosyntheticprocessDNAligationdouble-strandbreakrepairdouble-strandbreakrepairviaalternativenonhomologousendjoiningdouble-strandbreakrepairviahomologousrecombinationlaggingstrandelongationmitochondrialDNArepairmitochondrionorganizationnegativeregulationofmitochondrialDNAreplication
Zinc finger protein ZFAT
3.6
35
90
ZFATZFATQ9P243Q9P243hematopoieticprogenitorcelldifferentiationregulationofDNA-templatedtranscriptionspongiotrophoblastlayerdevelopment
E3 ubiquitin-protein ligase UBR2
3.6
69
89
UBR2UBR2Q8IWV8Q8IWV8cellularresponsetoleucineheterochromatinformationhistoneH2AubiquitinationmalemeiosisImalemeioticnucleardivisionnegativeregulationofTORsignalingnegativeregulationoftranspositionproteinubiquitinationreciprocalmeioticrecombinationspermatogenesisubiquitin-dependentproteincatabolicprocessviatheN-endrulepathway
F-box-like/WD repeat-containing protein TBL1XR1
3.6
90
69
TBL1RTBL1RQ9BZK7Q9BZK7blastocysthatchingchromatinorganizationfatpaddevelopmenthistonedeacetylationlipidcatabolicprocessmulticellularorganismgrowthnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftriglyceridemetabolicprocessresponsetodietaryexcesswhitefatcelldifferentiation
Eukaryotic translation initiation factor 5
3.6
46
90
IF5IF5P55010P55010formationofcytoplasmictranslationinitiationcomplexformationoftranslationpreinitiationcomplexregulationoftranslationalinitiation
Calcium-activated potassium channel subunit alpha-1
4.5
39
79
KCMA1KCMA1Q12791Q12791cellularpotassiumionhomeostasismicturitionnegativeregulationofcellvolumepositiveregulationofapoptoticprocesspotassiumiontransportregulationofiontransmembranetransportregulationofmembranepotentialrelaxationofvascularassociatedsmoothmuscleresponsetocalciumionresponsetocarbonmonoxideresponsetohypoxiaresponsetoosmoticstresssmoothmusclecontractioninvolvedinmicturition
Bromodomain-containing protein 1
3.7
51
89
BRD1BRD1O95696O95696erythrocytematurationhistoneH3acetylationpositiveregulationoferythrocytedifferentiationregulationofdevelopmentalprocessregulationofDNA-templatedtranscriptionregulationofhemopoiesisregulationoftranscriptionbyRNApolymeraseIIresponsetoelectricalstimulusresponsetoimmobilizationstress
Cell growth regulator with RING finger domain protein 1
3.8
55
88
CGRF1CGRF1Q99675Q99675cellcyclenegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationregulationofcellcycle
E3 ubiquitin-protein ligase synoviolin
4.0
37
82
SYVN1SYVN1Q86TM6Q86TM6endoplasmicreticulummannosetrimmingERADpathwayimmatureBcelldifferentiationnegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwayproteinK48-linkedubiquitinationproteinstabilizationproteinubiquitinationretrogradeproteintransportERtocytosolubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocess
TNF receptor-associated factor 3
3.6
55
88
TRAF3TRAF3Q13114Q13114apoptoticprocessdefenseresponsetovirusnegativeregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofJNKcascadeproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofcytokineproductionregulationofdefenseresponsetovirusregulationofI-kappaBkinase/NF-kappaBsignalingregulationofinterferon-betaproductionregulationofproteolysissignaltransductionTollsignalingpathwaytoll-likereceptorsignalingpathwayTRIF-dependenttoll-likereceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwaytypeIinterferon-mediatedsignalingpathway
E3 ubiquitin-protein ligase TRIM39
3.6
43
90
TRI39TRI39Q9HCM9Q9HCM9apoptoticprocessinnateimmuneresponsemitoticG2DNAdamagecheckpointsignalingnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofapoptoticsignalingpathwayproteinstabilizationproteinubiquitinationregulationofcellcycleG1/Sphasetransitionregulationofgeneexpression
E3 ubiquitin-protein ligase HERC2
3.6
56
87
HERC2HERC2O95714O95714cellularresponsetoDNAdamagestimulusDNArepairintracellularproteintransportproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationspermatogenesis
Zinc finger protein 473
3.6
43
90
ZN473ZN473Q8WTR7Q8WTR7"mRNA3-endprocessingbystem-loopbindingandcleavage"regulationoftranscriptionbyRNApolymeraseII
Zinc finger MYND domain-containing protein 10
3.6
56
90
ZMY10ZMY10O75800O75800ciliummovementinnerdyneinarmassemblymotileciliumassemblyouterdyneinarmassemblypositiveregulationofmotileciliumassemblyproteinlocalizationtocilium
[histone H3]-trimethyl-L-lysine(27) demethylase
3.6
53
87
F4MH27F4MH27F4MH27F4MH27
Telomere repeats-binding bouquet formation protein 1
3.8
45
82
TERB1TERB1Q8NA31Q8NA31homologouschromosomepairingatmeiosismeioticattachmentoftelomeretonuclearenvelopemeiotictelomereclustering
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
3.6
86
76
A0A8D1AAL8A0A8D1AAL8A0A8D1AAL8A0A8D1AAL8apoptoticmitochondrialchangesATPmetabolicprocessmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepotential
RING finger protein 141
4.0
41
88
RN141RN141Q8WVD5Q8WVD5proteinautoubiquitinationregulationofDNA-templatedtranscription
Sodium channel subunit beta-3
4.5
60
73
SCN3BSCN3BQ9NY72Q9NY72atrialcardiacmusclecellactionpotentialcardiacmusclecellactionpotentialinvolvedincontractioncardiacmusclecontractionmembranedepolarizationmembranedepolarizationduringactionpotentialmembranedepolarizationduringcardiacmusclecellactionpotentialnervoussystemdevelopmentpositiveregulationofheartratepositiveregulationofsodiumiontransportproteinlocalizationtoplasmamembraneregulationofatrialcardiacmusclecellmembranedepolarizationregulationofheartratebycardiacconductionregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranedepolarizationSAnodecellactionpotentialsensoryperceptionofpainsodiumiontransmembranetransportsodiumiontransportventricularcardiacmusclecellactionpotential
Rab-3A-interacting protein
3.6
76
82
RAB3IRAB3IQ96QF0Q96QF0ciliarybasalbody-plasmamembranedockingciliumassemblyexocytosisGolgitoplasmamembranetransportnegativeregulationoffilopodiumassemblyproteinlocalizationtoorganelleproteintargetingtomembrane
Protein odd-skipped-related 2
3.6
37
88
OSR2OSR2Q91ZD1Q91ZD1bonemorphogenesiscelldifferentiationcellpopulationproliferationchondrocytedifferentiationembryodevelopmentendinginbirthoregghatchingembryonicdigitmorphogenesisembryonicforelimbmorphogenesisembryonichindlimbmorphogenesisembryonicskeletaljointdevelopmentembryonicskeletaljointmorphogenesisembryonicskeletallimbjointmorphogenesisembryonicskeletalsystemmorphogenesiseyeliddevelopmentincamera-typeeyeheaddevelopmentmesonephrosdevelopmentmetanephrosdevelopmentmiddleearmorphogenesisnegativeregulationoftranscriptionbyRNApolymeraseIIodontogenesisosteoblastproliferationpositiveregulationofbonemineralizationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationpositiveregulationofgastrulationpositiveregulationofgeneexpressionpositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpronephrosdevelopmentregulationoftranscriptionbyRNApolymeraseIIroofofmouthdevelopmentstemcellproliferationurogenitalsystemdevelopment
RanBP-type and C3HC4-type zinc finger-containing protein 1
3.6
52
90
HOIL1HOIL1Q9BYM8Q9BYM8cytoplasmicsequesteringofproteindefenseresponsetobacteriumnegativeregulationofnecroptoticprocessnegativeregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinlinearpolyubiquitinationproteinpolyubiquitinationTcellreceptorsignalingpathway
Adenylate cyclase 9
4.3
67
81
E1BM79E1BM79E1BM79E1BM79adenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycAMPbiosyntheticprocessinuteroembryonicdevelopmentintracellularsignaltransduction
TRIM5/cyclophilin A V4 fusion protein
3.6
48
89
Q68KK2Q68KK2Q68KK2Q68KK2proteinfoldingproteinpeptidyl-prolylisomerization
Alcohol dehydrogenase 1C
3.6
69
87
ADH1GADH1GP00326P00326ethanoloxidationretinoicacidmetabolicprocessretinolmetabolicprocess
Poly [ADP-ribose] polymerase tankyrase-1
3.6
58
86
TNKS1TNKS1Q59FX0Q59FX0celldivisionmitoticspindleorganizationmRNAtransportnegativeregulationofmaintenanceofmitoticsisterchromatidcohesiontelomericnegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftelomericDNAbindingpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomerasepositiveregulationoftranscriptionbyRNApolymeraseIIproteinauto-ADP-ribosylationproteinlocalizationtochromosometelomericregionproteinpoly-ADP-ribosylationproteinpolyubiquitinationproteintransportregulationoftelomeremaintenanceviatelomerasespindleassemblyWntsignalingpathway
Thymidine kinase, cytosolic
3.5
59
83
✔
KITHKITHP04183P04183DNAbiosyntheticprocessnucleobase-containingcompoundmetabolicprocessphosphorylationproteinhomotetramerizationthymidinemetabolicprocess
Rab5 GDP/GTP exchange factor
3.8
49
86
RABX5RABX5O18973O18973endocytosisproteintransport
Glycine dehydrogenase (decarboxylating), mitochondrial
3.6
85
68
GCSPGCSPP23378P23378cellularresponsetoleukemiainhibitoryfactorglycinecatabolicprocessglycinedecarboxylationviaglycinecleavagesystemresponsetolipoicacidresponsetomethylamine
Glutaredoxin-2, mitochondrial
2.0
53
85
GLRX2GLRX2Q9NS18Q9NS18agingapoptoticprocesscelldifferentiationcellredoxhomeostasiscellularresponsetosuperoxideDNAprotectionglutathionemetabolicprocessregulationofDNA-templatedtranscriptionregulationofsignaltransductionresponsetohydrogenperoxideresponsetoorganicsubstanceresponsetoredoxstateresponsetotemperaturestimulus
L-serine dehydratase/L-threonine deaminase
3.6
98
65
SDHLSDHLP09367P09367gluconeogenesisisoleucinebiosyntheticprocessL-serinecatabolicprocesslipidmetabolicprocessprotein-containingcomplexassemblypyruvatebiosyntheticprocessresponsetoaminoacidresponsetocobalaminresponsetonutrientlevelsthreoninecatabolicprocess
Ubiquitin-like modifier-activating enzyme 5
3.6
87
79
UBA5UBA5Q9GZZ9Q9GZZ9erythrocytedifferentiationlocalizationmegakaryocytedifferentiationneuromuscularprocessproteinK69-linkedufmylationproteinmodificationbysmallproteinconjugationproteinufmylationregulationofintracellularestrogenreceptorsignalingpathwayresponsetoendoplasmicreticulumstressreticulophagyselectiveautophagy
Ubiquitin carboxyl-terminal hydrolase 8
3.8
55
88
UBP8UBP8P40818P40818cellularresponsetodexamethasonestimuluscellularresponsetonervegrowthfactorstimulusendosomeorganizationmitoticcytokinesisnegativeregulationoflysosomalproteincatabolicprocesspositiveregulationofamyloidfibrilformationpositiveregulationofcanonicalWntsignalingpathwayproteindeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitinationRasproteinsignaltransductionregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionregulationofproteinlocalizationregulationofproteinstabilityubiquitin-dependentproteincatabolicprocess
Mitochondrial ubiquitin ligase activator of NFKB 1
3.8
65
87
MUL1MUL1Q969V5Q969V5activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocesscellularresponsetoexogenousdsRNAmitochondrialfissionmitochondrionlocalizationnegativeregulationofcellgrowthnegativeregulationofchemokine(C-Cmotif)ligand5productionnegativeregulationofdefenseresponsetovirusbyhostnegativeregulationofinnateimmuneresponsenegativeregulationofmitochondrialfusionnegativeregulationofproteinkinaseBsignalingnegativeregulationoftypeIinterferon-mediatedsignalingpathwaypositiveregulationofautophagyofmitochondrioninresponsetomitochondrialdepolarizationpositiveregulationofdendriteextensionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmitochondrialfissionpositiveregulationofproteinsumoylationproteindestabilizationproteinpolyubiquitinationproteinstabilizationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwayregulationofmitochondrionorganization
Methylcytosine dioxygenase TET2
3.8
34
91
TET2TET2Q6N021Q6N0215-methylcytosinecatabolicprocesscellcyclechromatinorganizationDNAdemethylationleukocytedifferentiationmyeloidcelldifferentiationoxidativedemethylationoxidativeDNAdemethylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinO-linkedglycosylationresponsetoorganiccycliccompound
Nitric oxide synthase, inducible
3.9
69
78
NOS2NOS2P35228P35228argininecatabolicprocesscellredoxhomeostasiscellularresponsetolipopolysaccharidecellularresponsetotypeIIinterferoncellularresponsetoxenobioticstimuluscircadianrhythmdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriuminflammatoryresponseinnateimmuneresponseinmucosanegativeregulationofbloodpressurenegativeregulationofgeneexpressionnegativeregulationofproteincatabolicprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofguanylatecyclaseactivitypositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofkillingofcellsofanotherorganismpositiveregulationofleukocytemediatedcytotoxicityprostaglandinsecretionregulationofcellpopulationproliferationregulationofcellularrespirationregulationofcytokineproductioninvolvedininflammatoryresponseregulationofinsulinsecretionresponsetobacteriumresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharidesuperoxidemetabolicprocess
Protein argonaute-3
3.6
74
73
AGO3AGO3Q9H9G7Q9H9G7miRNAprocessingmiRNA-mediatedgenesilencingbyinhibitionoftranslationmRNAcatabolicprocesspositiveregulationofgeneexpressionpositiveregulationofNIK/NF-kappaBsignalingpre-miRNAprocessingregulationofstemcellproliferationRISCcomplexassemblyRNAsecondarystructureunwinding
Protein AF-10
4.0
69
91
AF10AF10P55197P55197histoneH3-K27methylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Protein kinase C gamma type
4.0
52
88
KPCGKPCGP05129P05129chemicalsynaptictransmissionchemosensorybehaviorinnervationintracellularsignaltransductionlearningormemorylong-termsynapticpotentiationnegativeregulationofneuronapoptoticprocessnegativeregulationofproteasomalproteincatabolicprocessnegativeregulationofproteincatabolicprocessnegativeregulationofproteinubiquitinationpeptidyl-serinephosphorylationphosphorylationpositiveregulationofmismatchrepairpresynapticmodulationofchemicalsynaptictransmissionproteinautophosphorylationproteinphosphorylationregulationofcircadianrhythmregulationofphagocytosisregulationofresponsetofoodregulationofsynapticvesicleexocytosisresponsetomorphineresponsetopainresponsetopsychosocialstressresponsetotoxicsubstancerhythmicprocess
E3 ubiquitin-protein ligase TRIM23
3.6
60
84
TRI23TRI23P36406P36406innateimmuneresponseintracellularproteintransportproteinubiquitinationvesicle-mediatedtransport
Target of rapamycin complex subunit LST8
3.6
97
75
✔
LST8LST8Q9BVC4Q9BVC4cellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetonutrientlevelscellularresponsetoosmoticstresscytoskeletonorganizationnegativeregulationofapoptoticprocessnegativeregulationofautophagyphosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellgrowthpositiveregulationofglycolyticprocesspositiveregulationoflipidbiosyntheticprocesspositiveregulationofpentose-phosphateshuntpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTORsignalingregulationofactincytoskeletonorganizationregulationofGTPaseactivityTORsignalingTORC1signaling
Peregrin
3.8
63
92
BRPF1BRPF1P55201P55201chromatinorganizationhistoneH3-K23acetylationpositiveregulationofDNA-templatedtranscriptionregulationofdevelopmentalprocessregulationofDNA-templatedtranscriptionregulationofhemopoiesisregulationoftranscriptionbyRNApolymeraseII
Cyclic GMP-AMP synthase
3.9
67
88
CGASCGASQ8N884Q8N884activationofinnateimmuneresponsecAMP-mediatedsignalingcellularresponsetoDNAdamagestimuluscellularresponsetoexogenousdsRNAcGMP-mediatedsignalingdefenseresponsetovirusdeterminationofadultlifespanDNArepairinnateimmuneresponsenegativeregulationofdouble-strandbreakrepairviahomologousrecombinationparacrinesignalingpositiveregulationofcellularsenescencepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationoftypeIinterferonproductionregulationofimmunoglobulinproductionregulationofTcellactivation
Zinc finger protein ZIC 3
3.9
44
84
ZIC3ZIC3O60481O60481atrialcardiacmuscletissuedevelopmentaxialmesodermdevelopmentcentralnervoussystemdevelopmentcentralnervoussystemsegmentationcranialskeletalsystemdevelopmentdeterminationofdigestivetractleft/rightasymmetrydeterminationofleft/rightasymmetryinnervoussystemdeterminationofleft/rightsymmetrydeterminationofliverleft/rightasymmetrydeterminationofpancreaticleft/rightasymmetryembryonicpatternspecificationfacedevelopmentgerm-linestemcellpopulationmaintenanceheartloopinghippocampusdevelopmentleft/rightaxisspecificationlimbmorphogenesislungdevelopmentmRNAtranscriptionbyRNApolymeraseIIneuralplatedevelopmentneurondifferentiationolfactorybulbdevelopmentouterearmorphogenesisparaxialmesodermdevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIprimitivestreakformationregulationofDNA-bindingtranscriptionfactoractivityregulationoftranscriptionbyRNApolymeraseIIskeletalsystemdevelopmentsmoothenedsignalingpathwaystemcelldifferentiation
Potassium channel subfamily U member 1
3.6
89
69
KCNU1KCNU1A8MYU2A8MYU2regulationofiontransmembranetransportreproductiveprocess
E3 ubiquitin-protein ligase RNF25
3.6
36
86
RNF25RNF25Q96BH1Q96BH1positiveregulationofNF-kappaBtranscriptionfactoractivityproteinubiquitination
Dual specificity protein phosphatase 5
2.0
57
85
DUS5DUS5Q16690Q16690dephosphorylationendodermformationERK1andERK2cascadeMAPKcascadenegativeregulationofMAPKcascadepeptidyl-threoninedephosphorylationpeptidyl-tyrosinedephosphorylationproteindephosphorylation
RNA demethylase ALKBH5
3.6
62
71
ALKB5ALKB5Q6P6C2Q6P6C2celldifferentiationmRNAexportfromnucleusmRNAprocessingoxidativesingle-strandedRNAdemethylationregulationofmRNAstabilityresponsetohypoxiaspermatogenesis
Tubulin polyglutamylase TTLL6
3.6
81
59
TTLL6TTLL6A4Q9E8A4Q9E8microtubulebundleformationmicrotubulecytoskeletonorganizationmicrotubuleseveringpositiveregulationofciliummovementproteinpolyglutamylationregulationofciliumbeatfrequencyinvolvedinciliarymotility
Ig gamma-3 chain C region
2.0
82
80
IGHG3IGHG3P22436P22436regulationofimmuneresponse
Leucine--tRNA ligase, cytoplasmic
3.6
91
72
SYLCSYLCQ9P2J5Q9P2J5cellularresponsetoaminoacidstarvationcellularresponsetoaminoacidstimuluscellularresponsetoleucinecellularresponsetoleucinestarvationglutaminyl-tRNAaminoacylationleucyl-tRNAaminoacylationpositiveregulationofGTPaseactivitypositiveregulationofTORsignalingpositiveregulationofTORC1signalingregulationofcellsizetRNAaminoacylationforproteintranslation
Autophagy-related protein 16-1
3.6
90
70
A16L1A16L1Q676U5Q676U5autophagosomeassemblyC-terminalproteinlipidationcorpuscallosumdevelopmentdefenseresponsetovirushippocampusdevelopmentlysosomalmicroautophagymacroautophagynegativestrandedviralRNAreplicationpositiveregulationofautophagyproteinlipidationproteinlipidationinvolvedinautophagosomeassemblyproteinlocalizationtophagophoreassemblysiteproteintransportxenophagy
C->U-editing enzyme APOBEC-2
3.6
58
88
ABEC2ABEC2Q9Y235Q9Y235cytidinetouridineeditingDNAdemethylationmRNAmodificationmRNAprocessing
Sequestosome-1
3.6
56
88
SQSTMSQSTMQ13501Q13501aggrephagyapoptoticprocessautophagyautophagyofmitochondrionbrownfatcellproliferationcelldifferentiationendosomaltransportendosomeorganizationenergyhomeostasisimmunesystemprocessintracellularsignaltransductionmacroautophagymitophagynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpexophagypositiveregulationofapoptoticprocesspositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusproteinlocalizationproteinlocalizationtoperinuclearregionofcytoplasmproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmitochondrionorganizationregulationofproteincomplexstabilityregulationofRasproteinsignaltransductionresponsetoischemiaresponsetomitochondrialdepolarisationselectiveautophagytemperaturehomeostasistranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
Apoptosis-stimulating of p53 protein 2
3.9
68
85
ASPP2ASPP2Q13625Q13625cellcycleintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofcellcyclepositiveregulationofexecutionphaseofapoptosissignaltransduction
Hexokinase-4
3.6
85
69
HXK4HXK4P35557P35557calciumionimportcanonicalglycolysiscarbohydratephosphorylationcellularglucosehomeostasiscellularresponsetoinsulinstimuluscellularresponsetoleptinstimulusdetectionofglucoseglucose6-phosphatemetabolicprocessglucosehomeostasisglucosemetabolicprocessglycolyticprocessNADPmetabolicprocessnegativeregulationofgluconeogenesispositiveregulationofglycogenbiosyntheticprocesspositiveregulationofinsulinsecretionregulationofglycolyticprocessregulationofinsulinsecretionregulationofpotassiumiontransport
Lysine-specific demethylase 6A
3.9
66
86
KDM6AKDM6AO15550O15550chromatinremodelingheartdevelopmenthistoneH3-K27demethylationhistoneH3-K4methylationregulationofgeneexpression
Ataxin-7
3.6
63
86
ATX7ATX7O15265O15265histoneH3acetylationmicrotubulecytoskeletonorganizationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationnegativeregulationofmicrotubuledepolymerizationnucleusorganizationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseIIvisualperception
Methyl-CpG-binding domain protein 1
3.7
38
87
MBD1MBD1Q9UIS9Q9UIS9negativeregulationofDNA-templatedtranscriptiontranscriptionbyRNApolymeraseII
TRA@ protein
2.0
87
81
Q6P4G7Q6P4G7Q6P4G7Q6P4G7
PR domain zinc finger protein 9
3.8
36
87
D9IWL3D9IWL3D9IWL3D9IWL3methylation
Early growth response protein 1
3.9
37
90
EGR1EGR1P08046P08046BMPsignalingpathwaycellularresponsetogammaradiationcellularresponsetoheparincellularresponsetointerleukin-8cellularresponsetomycophenolicacidcellularresponsetoorganicsubstancecircadianregulationofgeneexpressioncircadiantemperaturehomeostasisestrouscycleglomerularmesangialcellproliferationinterleukin-1-mediatedsignalingpathwaylearningormemorylocomotorrhythmlong-termmemorynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcelldeathpositiveregulationofchemokineproductionpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofglomerularmetanephricmesangialcellproliferationpositiveregulationofhormonebiosyntheticprocesspositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofpost-translationalproteinmodificationpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIregulationofapoptoticprocessregulationofDNA-templatedtranscriptionregulationoflong-termneuronalsynapticplasticityregulationofprogesteronebiosyntheticprocessregulationofproteinsumoylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiaresponsetoglucoseresponsetohypoxiaresponsetoinsulinresponsetoischemiaskeletalmusclecelldifferentiationTcelldifferentiation
Ribokinase
3.6
107
68
RBSKRBSKQ9H477Q9H477D-ribosecatabolicprocesspentose-phosphateshunt
DNA-directed RNA polymerase I subunit RPA12
3.6
48
90
RPA12RPA12Q9P1U0Q9P1U0mRNAcleavagenucleobase-containingcompoundmetabolicprocessterminationofRNApolymeraseItranscription
S-adenosylmethionine synthase isoform type-1
3.6
87
70
METK1METK1P13444P13444methioninecatabolicprocessone-carbonmetabolicprocessproteinhomotetramerizationprotein-containingcomplexassemblyS-adenosylmethioninebiosyntheticprocess
Rac GTPase-activating protein 1
3.6
54
94
RGAP1RGAP1Q9H0H5Q9H0H5actomyosincontractileringassemblyerythrocytedifferentiationmitoticcytokinesismitoticspindlemidzoneassemblyneuroblastproliferationpositiveregulationofcytokinesisregulationofattachmentofspindlemicrotubulestokinetochoreregulationofembryonicdevelopmentregulationofsmallGTPasemediatedsignaltransductionRhoproteinsignaltransductionspermatogenesissulfatetransport
NTF2-related export protein 1
3.6
90
72
NXT1NXT1Q9UKK6Q9UKK6mRNAexportfromnucleusnucleocytoplasmictransportproteinexportfromnucleusproteinimportintonucleus
tRNA (guanine-N(7)-)-methyltransferase
3.6
88
71
TRMBTRMBQ9UBP6Q9UBP6RNA(guanine-N7)-methylationtRNAmethylationtRNAmodification
Pyrroline-5-carboxylate reductase 1, mitochondrial
3.6
85
67
✔
P5CR1P5CR1P32322P32322cellularresponsetooxidativestressL-prolinebiosyntheticprocessnegativeregulationofhydrogenperoxide-inducedcelldeathprolinebiosyntheticprocessregulationofmitochondrialmembranepotential
Adenine phosphoribosyltransferase
3.6
88
71
✔
APTAPTP07741P07741adeninesalvageAMPsalvagecellularresponsetoinsulinstimulusGMPsalvagegroomingbehaviorIMPsalvagelactationpurineribonucleosidesalvage
Nitric oxide synthase, endothelial
4.0
59
81
NOS3NOS3P29474P29474angiogenesisaorticvalvemorphogenesisargininecatabolicprocessbloodvesseldiametermaintenancebloodvesselremodelingcalciumiontransportcellredoxhomeostasisendocardialcushionmorphogenesisendothelialcellmigrationestablishmentoflocalizationincellhomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentlipopolysaccharide-mediatedsignalingpathwaylungdevelopmentmitochondrionorganizationnegativeregulationofbiomineraltissuedevelopmentnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhydrolaseactivitynegativeregulationofmusclehyperplasianegativeregulationofplateletactivationnegativeregulationofpotassiumiontransportnegativeregulationofsmoothmusclecellproliferationnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionovulationfromovarianfolliclepositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofguanylatecyclaseactivitypositiveregulationofNotchsignalingpathwaypotassiumiontransportpulmonaryvalvemorphogenesisregulationofbloodpressureregulationofnervoussystemprocessregulationofsodiumiontransportregulationofsystemicarterialbloodpressurebyendothelinregulationoftheforceofheartcontractionbychemicalsignalremovalofsuperoxideradicalsresponsetofluidshearstressresponsetoheatresponsetohormoneresponsetolipopolysaccharidesmoothmusclehyperplasiavasodilationventricularseptummorphogenesis
N-acylneuraminate-9-phosphatase
3.6
61
79
NANPNANPQ8TBE9Q8TBE9carbohydratemetabolicprocessdephosphorylationN-acetylglucosaminebiosyntheticprocessN-acetylneuraminatebiosyntheticprocess
2-oxoadipate dehydrogenase complex component E1
3.6
88
67
DHTK1DHTK1Q96HY7Q96HY7generationofprecursormetabolitesandenergyglycolyticprocesshematopoieticprogenitorcelldifferentiationtricarboxylicacidcycle
Poly [ADP-ribose] polymerase tankyrase-2
3.6
58
87
TNKS2TNKS2Q9H2K2Q9H2K2multicellularorganismgrowthnegativeregulationoftelomeremaintenanceviatelomerelengtheningpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomeraseproteinauto-ADP-ribosylationproteinlocalizationtochromosometelomericregionproteinpoly-ADP-ribosylationproteinpolyubiquitinationregulationofmulticellularorganismgrowthWntsignalingpathway
Guanine nucleotide exchange factor MSS4
3.8
56
82
MSS4MSS4Q08326Q08326post-Golgivesicle-mediatedtransportproteintransportsmallGTPasemediatedsignaltransduction
Tripartite motif-containing 66
3.8
63
88
E9PZP2E9PZP2E9PZP2E9PZP2
Zinc finger MIZ domain-containing protein 1
3.6
71
76
ZMIZ1ZMIZ1Q9ULJ6Q9ULJ6androgenreceptorsignalingpathwayarterymorphogenesiscellularsenescencedevelopmentalgrowthheartmorphogenesisinuteroembryonicdevelopmentpositiveregulationoffibroblastproliferationpositiveregulationofNotchsignalingpathwaypositiveregulationofnucleicacid-templatedtranscriptionpositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpyramidalneuronmigrationtocerebralcortexregulationofproteinsumoylationregulationoftranscriptionbyRNApolymeraseIISMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayvasculogenesisvitellogenesis
Signal transducer and activator of transcription 6
3.6
79
74
STAT6STAT6P42226P42226cellularresponsetohydrogenperoxidecellularresponsetoreactivenitrogenspeciescytokine-mediatedsignalingpathwaydefenseresponsegrowthhormonereceptorsignalingpathwayviaJAK-STATinterleukin-4-mediatedsignalingpathwayisotypeswitchingtoIgEisotypesmammaryglandepithelialcellproliferationmammaryglandmorphogenesisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftype2immuneresponsepositiveregulationofcold-inducedthermogenesispositiveregulationofisotypeswitchingtoIgEisotypespositiveregulationoftranscriptionbyRNApolymeraseIIreceptorsignalingpathwayviaJAK-STATregulationofcellpopulationproliferationregulationofmastcellproliferationregulationoftranscriptionbyRNApolymeraseIIresponsetopeptidehormonesignaltransductionT-helper1celllineagecommitment
Polycystic kidney disease 2-like 1 protein
3.6
52
80
PK2L1PK2L1Q9P0L9Q9P0L9cationtransportcellularresponsetoacidicpHdetectionofchemicalstimulusinvolvedinsensoryperceptionofsourtastedetectionofchemicalstimulusinvolvedinsensoryperceptionoftastedetectionofmechanicalstimulusinorganiccationtransmembranetransportpotassiumiontransmembranetransportproteinhomotetramerizationresponsetowatersensoryperceptionofsourtastesmoothenedsignalingpathwaysodiumiontransmembranetransport
Transcription elongation factor A protein 1
3.8
41
89
✔
TCEA1TCEA1P23193P23193DNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoter
Macrophage-capping protein
3.6
82
76
CAPGCAPGP40121P40121actinfilamentseveringactinpolymerizationordepolymerizationbarbed-endactinfilamentcappingcellprojectionassemblycentralnervoussystemdevelopmentprotein-containingcomplexassembly
Transient receptor potential cation channel subfamily M member 4
3.6
73
77
TRPM4TRPM4Q8TD43Q8TD43adaptiveimmuneresponsecalciumiontransmembranetransportcalcium-mediatedsignalingcationtransmembranetransportcellularresponsetoATPdendriticcellchemotaxisinorganiccationtransmembranetransportmembranedepolarizationduringAVnodecellactionpotentialmembranedepolarizationduringbundleofHiscellactionpotentialmembranedepolarizationduringPurkinjemyocytecellactionpotentialnegativeregulationofbonemineralizationnegativeregulationofosteoblastdifferentiationpositiveregulationofadiposetissuedevelopmentpositiveregulationofatrialcardiacmusclecellactionpotentialpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationoffatcelldifferentiationpositiveregulationofheartratepositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofregulationofvascularassociatedsmoothmusclecellmembranedepolarizationpositiveregulationofvasoconstrictionproteinhomotetramerizationproteinsumoylationregulationofheartratebycardiacconductionregulationofTcellcytokineproductionregulationofventricularcardiacmusclecellactionpotentialsodiumionimportacrossplasmamembrane
Aryl hydrocarbon receptor nuclear translocator
3.6
70
75
ARNTARNTP53762P53762celldifferentiationembryonicplacentadevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofhormonebiosyntheticprocesspositiveregulationofproteinsumoylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialgrowthfactorproductionregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressresponsetohypoxiaresponsetotoxicsubstance
All-trans-retinol dehydrogenase [NAD(+)] ADH4
3.6
48
88
ADH4ADH4P08319P08319alcoholcatabolicprocessalcoholmetabolicprocesscellularaldehydemetabolicprocessethanoloxidationfattyacidomega-oxidationformaldehydecatabolicprocessquinonemetabolicprocessretinoidmetabolicprocessretinolmetabolicprocess
28S ribosomal protein S18b, mitochondrial
3.6
64
84
RT18BRT18BQ9Y676Q9Y676mitochondrialtranslationtranslation
Double-stranded RNA-specific editase 1
3.6
81
54
RED1RED1P78563P78563adenosinetoinosineeditingbaseconversionorsubstitutioneditingdefenseresponsetovirusfacialnervemorphogenesishypoglossalnervemorphogenesisinnateimmuneresponseinnervationmotorbehaviormotorneuronapoptoticprocessmRNAprocessingmulticellularorganismgrowthmuscletissuemorphogenesisnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofproteinkinaseactivitybyregulationofproteinphosphorylationneuromuscularprocesscontrollingpostureneuromuscularsynaptictransmissionpositiveregulationofviralgenomereplicationregulationofcellcycleRNAprocessingspinalcordventralcommissuremorphogenesis
F-box only protein 11
3.9
53
87
FBX11FBX11Q86XK2Q86XK2negativeregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelpositiveregulationofproteincatabolicprocessproteinmodificationprocessproteinubiquitinationregulationofapoptoticprocesssensoryperceptionofsoundubiquitin-dependentproteincatabolicprocess
histone acetyltransferase
3.6
45
94
Q6GQV9Q6GQV9Q6GQV9Q6GQV9histoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseII
Mediator of RNA polymerase II transcription subunit 14
3.6
57
83
MED14MED14O60244O60244positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblysomaticstemcellpopulationmaintenance
Zinc finger protein 347
3.6
34
89
ZN347ZN347Q96SE7Q96SE7regulationoftranscriptionbyRNApolymeraseII
Potassium voltage-gated channel subfamily D member 2
3.6
65
76
A0A6P6DHQ6A0A6P6DHQ6A0A6P6DHQ6A0A6P6DHQ6proteinhomooligomerizationregulationofiontransmembranetransport
CAP-Gly domain-containing linker protein 1
4.0
62
74
CLIP1CLIP1P30622P30622cytoplasmicmicrotubuleorganizationmicrotubulebundleformationmitoticcellcyclepositiveregulationofmicrotubulepolymerization
Zinc finger protein 28 homolog
3.6
40
88
ZFP28ZFP28Q8NHY6Q8NHY6regulationoftranscriptionbyRNApolymeraseII
Zinc finger Ran-binding domain-containing protein 2
3.8
52
92
✔
ZRAB2ZRAB2O95218O95218mRNAprocessingRNAsplicing
SLIT-ROBO Rho GTPase-activating protein 2
3.6
56
80
SRGP2SRGP2O75044O75044actinfilamentseveringdendriticspinedevelopmentexcitatorysynapseassemblyextensionofaleadingprocessinvolvedincellmotilityincerebralcortexradialgliaguidedmigrationfilopodiumassemblyinhibitorysynapseassemblylamellipodiumassemblyinvolvedinameboidalcellmigrationnegativeregulationofcellmigrationnegativeregulationofneuronmigrationneuronprojectionmorphogenesispositiveregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionsignaltransductionsubstrateadhesion-dependentcellspreading
U11/U12 small nuclear ribonucleoprotein 48 kDa protein
3.6
49
86
SNR48SNR48Q6IEG0Q6IEG0mRNAprocessingRNAsplicing
Muscleblind-like protein 1
3.9
46
89
✔
MBNL1MBNL1Q9NR56Q9NR56embryoniclimbmorphogenesisinuteroembryonicdevelopmentmRNAprocessingmyoblastdifferentiationnervoussystemdevelopmentregulationofalternativemRNAsplicingviaspliceosomeregulationofRNAsplicingRNAsplicing
E3 ubiquitin-protein ligase ARIH2
3.7
nan
94
ARI2ARI2O95376O95376developmentalcellgrowthhematopoieticstemcellproliferationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteintargetingtomitochondrionproteinK48-linkedubiquitinationproteinK63-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
ATP-binding cassette sub-family G member 8
3.6
59
77
ABCG8ABCG8Q9H221Q9H221bileacidsignalingpathwaycholesteroleffluxcholesterolhomeostasisintestinalcholesterolabsorptionnegativeregulationofintestinalcholesterolabsorptionnegativeregulationofintestinalphytosterolabsorptionphospholipidtransportresponsetomuscleactivityresponsetonutrientresponsetoxenobioticstimulussteroltransporttransmembranetransporttriglyceridehomeostasis
Hexokinase-3
3.6
88
69
HXK3HXK3P52790P52790canonicalglycolysiscarbohydratephosphorylationcellularglucosehomeostasisfructose6-phosphatemetabolicprocessglucose6-phosphatemetabolicprocessglucosemetabolicprocessglycolyticprocess
Serine/threonine-protein kinase SMG1
3.6
51
80
SMG1SMG1Q96Q15Q96Q15DNArepairmRNAexportfromnucleusnegativeregulationofmacroautophagynuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaypeptidyl-serinephosphorylationphosphatidylinositolphosphatebiosyntheticprocessproteinautophosphorylationproteinphosphorylationregulationofresponsetoDNAdamagestimulusregulationoftelomeremaintenanceTORsignaling
Protein transport protein Sec24B
3.9
52
89
SC24BSC24BO95487O95487aortamorphogenesisauditoryreceptorcellstereociliumorganizationcochlearnucleusdevelopmentCOPII-coatedvesiclecargoloadingcoronaryarterymorphogenesisendoplasmicreticulumtoGolgivesicle-mediatedtransportintracellularproteintransportlunglobemorphogenesisneuraltubeclosureoutflowtractmorphogenesispulmonaryarterymorphogenesisregulationofcargoloadingintoCOPII-coatedvesicleregulationofestablishmentofplanarpolarityinvolvedinneuraltubeclosure
Regulator of nonsense transcripts 2
3.6
63
77
RENT2RENT2Q9HAU5Q9HAU5animalorganregenerationliverdevelopmentmRNAexportfromnucleusnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecay
Steroid hormone receptor ERR2
3.6
46
93
ERR2ERR2O95718O95718celldedifferentiationcellpopulationproliferationinnereardevelopmentnegativeregulationofstemcelldifferentiationphotoreceptorcellmaintenancepositiveregulationofDNA-templatedtranscriptionpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcyclepositiveregulationoftranscriptioninvolvedinG2/MtransitionofmitoticcellcycleregulationofDNA-templatedtranscriptionregulationofstemcelldivisionregulationoftranscriptionbyRNApolymeraseIIstemcelldivisionstemcellpopulationmaintenance
Sodium/potassium-transporting ATPase subunit alpha
3.8
82
73
I7HD36I7HD36I7HD36I7HD36
Mothers against decapentaplegic homolog 4
3.8
68
78
SMAD4SMAD4Q13485Q13485activinreceptorsignalingpathwayadrenalglanddevelopmentaginganatomicalstructuremorphogenesisatrioventricularcanaldevelopmentatrioventricularvalveformationaxonguidanceBMPsignalingpathwaybrainstemdevelopmentbranchinginvolvedinuretericbudmorphogenesiscardiacconductionsystemdevelopmentcelldifferentiationcellpopulationproliferationcellularironionhomeostasiscellularresponsetoBMPstimuluscellularresponsetoglucosestimulusdevelopmentalgrowthDNA-templatedtranscriptionembryonicdigitmorphogenesisendocardialcelldifferentiationendodermdevelopmentendothelialcellactivationepithelialcellmigrationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationERK1andERK2cascadefemalegonadmorphogenesisformationofanatomicalboundarygastrulationwithmouthformingsecondinuteroembryonicdevelopmentinterleukin-6-mediatedsignalingpathwayintracellularsignaltransductionleftventricularcardiacmuscletissuemorphogenesismesodermdevelopmentmetanephricmesenchymemorphogenesisnegativeregulationofcardiacmusclehypertrophynegativeregulationofcardiacmyofibrilassemblynegativeregulationofcelldeathnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofERK1andERK2cascadenegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInephrogenicmesenchymemorphogenesisneuralcrestcelldifferentiationneuronfatecommitmentosteoblastdifferentiationoutflowtractseptummorphogenesisovarianfollicledevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcellproliferationinvolvedinheartvalvemorphogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K9acetylationpositiveregulationofluteinizinghormonesecretionpositiveregulationofmiRNAtranscriptionpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofSMADproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofbindingregulationofhairfollicledevelopmentregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiaresponsetotransforminggrowthfactorbetasebaceousglanddevelopmentsecondarypalatedevelopmentseminiferoustubuledevelopmentsinglefertilizationSMADproteincomplexassemblySMADproteinsignaltransductionsomiterostral/caudalaxisspecificationspermatogenesistranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathwayuterusdevelopmentventricularseptummorphogenesiswoundhealing
DNA annealing helicase and endonuclease ZRANB3
3.7
51
90
ZRAB3ZRAB3Q5FWF4Q5FWF4cellularresponsetoDNAdamagestimulusDNArepairDNArewindingnegativeregulationofDNArecombinationreplicationforkprocessingreplicationforkprotectionresponsetoUV
N-alpha-acetyltransferase 25, NatB auxiliary subunit
3.6
77
68
✔
NAA25NAA25Q14CX7Q14CX7N-terminalpeptidyl-methionineacetylation
Integrator complex subunit 1
3.6
64
75
✔
INT1INT1Q8N201Q8N201innercellmasscellproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessregulationoftranscriptionelongationbyRNApolymeraseIIsnRNAprocessing"U2snRNA3-endprocessing"
Death-inducer obliterator 1
3.9
60
88
DIDO1DIDO1Q8C9B9Q8C9B9apoptoticsignalingpathwayDNA-templatedtranscription
Queuine tRNA-ribosyltransferase catalytic subunit 1
3.6
60
78
TGTTGTQ9BXR0Q9BXR0tRNAmodificationtRNA-guaninetransglycosylation
Probable E3 ubiquitin-protein ligase MID2
3.6
55
87
TRIM1TRIM1Q9UJV3Q9UJV3innateimmuneresponsenegativeregulationofviralentryintohostcellnegativeregulationofviraltranscriptionpositiveregulationofautophagypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinlocalizationtomicrotubuleproteinubiquitinationsuppressionofviralreleasebyhost
Whirlin
3.6
74
76
WHRNWHRNQ80VW5Q80VW5auditoryreceptorcellstereociliumorganizationcerebellarPurkinjecelllayerformationdetectionofmechanicalstimulusinvolvedinsensoryperceptionofsoundestablishmentoflocalizationincellestablishmentofproteinlocalizationinnerearreceptorcelldifferentiationinnerearreceptorcellstereociliumorganizationparanodaljunctionmaintenancepositiveregulationofgeneexpressionretinahomeostasissensoryperceptionoflightstimulussensoryperceptionofsound
Probable ATP-dependent RNA helicase DDX17
3.6
77
80
DDX17DDX17Q92841Q92841alternativemRNAsplicingviaspliceosomeandrogenreceptorsignalingpathwaydefenseresponsetovirusepithelialtomesenchymaltransitionimmunesystemprocessintracellularestrogenreceptorsignalingpathwaymiRNAmetabolicprocessmyoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofalternativemRNAsplicingviaspliceosomeregulationofskeletalmusclecelldifferentiationregulationoftranscriptionbyRNApolymeraseIIRNAprocessingRNA-mediatedgenesilencingrRNAprocessing
Zinc finger protein ubi-d4
3.8
48
86
REQUREQUQ92785Q92785apoptoticprocessapoptoticsignalingpathwaychromatinremodelingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofmyeloidprogenitorcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpositiveregulationofdouble-strandbreakrepairpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
IgG receptor FcRn large subunit p51
3.6
84
73
FCGRNFCGRNP55899P55899IgGimmunoglobulintranscytosisinepithelialcellsmediatedbyFcRnimmunoglobulinreceptor
Cysteine-rich PDZ-binding protein
3.8
42
87
CRIPTCRIPTQ9P021Q9P021cytoplasmicmicrotubuleorganizationestablishmentofproteinlocalizationproteinlocalizationtomicrotubuleregulationofpostsynapticdensityassemblyregulationofpostsynapticdensityprotein95clustering
Zinc finger protein 484
3.6
37
90
ZN484ZN484Q5JVG2Q5JVG2regulationoftranscriptionbyRNApolymeraseII
5-hydroxytryptamine (serotonin) receptor 3A
3.6
67
74
Q8K1F4Q8K1F4Q8K1F4Q8K1F4
Histone-lysine N-methyltransferase 2C
3.7
43
88
KMT2CKMT2CQ8NEZ4Q8NEZ4chromatinorganizationhistoneH3-K4methylationhistoneH3-K4monomethylationpositiveregulationoftranscriptionbyRNApolymeraseII
DnaJ homolog subfamily C member 24
3.6
50
87
DJC24DJC24Q6P3W2Q6P3W2chaperone-mediatedproteinfoldingpeptidyl-diphthamidebiosyntheticprocessfrompeptidyl-histidinepositiveregulationofATP-dependentactivity
Ran-binding protein 9
3.6
83
68
RANB9RANB9Q96S59Q96S59cellsurfacereceptorsignalingpathwaycytoskeletonorganizationmicrotubulenucleationnegativeregulationofERK1andERK2cascadepositiveregulationofamyloidprecursorproteincatabolicprocessprotein-containingcomplexassembly
Aldehyde dehydrogenase X, mitochondrial
3.6
84
78
✔
AL1B1AL1B1P30837P30837carbohydratemetabolicprocessethanolcatabolicprocess
Pre-mRNA-splicing factor SLU7
3.6
69
74
SLU7SLU7O95391O95391alternativemRNAsplicingviaspliceosomecellularresponsetoheatintracellularproteintransport"mRNA3-splicesiterecognition"mRNAsplicingviaspliceosomeRNAsplicingRNAsplicingviatransesterificationreactions
E3 ubiquitin-protein ligase TRIM32
4.0
45
84
TRI32TRI32Q13049Q13049actinubiquitinationaxondevelopmentfatcelldifferentiationfreeubiquitinchainpolymerizationinnateimmuneresponsemusclecellcellularhomeostasisnegativeregulationoffibroblastproliferationnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofviraltranscriptionpositiveregulationofautophagypositiveregulationofcellcyclepositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofcellmotilitypositiveregulationofchemokine(C-Cmotif)ligand20productionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-17-mediatedsignalingpathwaypositiveregulationofneurogenesispositiveregulationofneurondifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteincatabolicprocesspositiveregulationofproteolysispositiveregulationofstriatedmusclecelldifferentiationpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationresponsetotumornecrosisfactorresponsetoUVsuppressionofviralreleasebyhosttissuehomeostasisubiquitin-dependentproteincatabolicprocess
Glutaminyl-peptide cyclotransferase-like protein
3.6
98
66
QPCTLQPCTLQ9NXS2Q9NXS2peptidyl-pyroglutamicacidbiosyntheticprocessusingglutaminyl-peptidecyclotransferase
Tyrosine aminotransferase
3.6
91
67
ATTYATTYP17735P177352-oxoglutaratemetabolicprocessbiosyntheticprocessglutamatemetabolicprocessL-phenylalaninecatabolicprocessresponsetodexamethasoneresponsetomercuryionresponsetooxidativestresstyrosinecatabolicprocess
Lysosomal cobalamin transporter ABCD4
3.6
77
78
ABCD4ABCD4O14678O14678cellularresponsetoleukemiainhibitoryfactorcobalaminmetabolicprocesscobalamintransportfattyacidbeta-oxidationlong-chainfattyacidimportintoperoxisomeperoxisomeorganizationtransmembranetransportverylong-chainfattyacidcatabolicprocess
Protein lin-28 homolog A
3.6
50
91
LN28ALN28AQ8K3Y3Q8K3Y3cellularresponsetoglucosestimulusgermcelldevelopmentmiRNAcatabolicprocessmiRNAmetabolicprocessnegativeregulationofglialcelldifferentiationnegativeregulationoftranslationpositiveregulationofcellproliferationinvolvedinkidneydevelopmentpositiveregulationofcytoplasmictranslationpositiveregulationofneurondifferentiationpositiveregulationofproteinkinaseBsignalingpositiveregulationofTORsignalingpositiveregulationoftranslationpre-miRNAprocessingregulationofmiRNA-mediatedgenesilencing"RNA3uridylation""RNA3-endprocessing"stemcelldifferentiationstemcellpopulationmaintenance
WD repeat-containing protein 20
3.6
68
79
WDR20WDR20Q8TBZ3Q8TBZ3
Ubiquitin carboxyl-terminal hydrolase 34
3.6
49
85
UBP34UBP34Q70CQ2Q70CQ2positiveregulationofcanonicalWntsignalingpathwayproteindeubiquitinationproteinK48-linkeddeubiquitinationubiquitin-dependentproteincatabolicprocessWntsignalingpathway
DNA (cytosine-5)-methyltransferase 3B
3.1
nan
94
✔
DNM3BDNM3BQ9UBC3Q9UBC3C-5methylationofcytosineDNAmethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpression
NAPA protein
3.6
76
76
A5D7S0A5D7S0A5D7S0A5D7S0intracellularproteintransportvesicle-mediatedtransport
Ubiquitin carboxyl-terminal hydrolase CYLD
3.6
42
83
J3KRR7J3KRR7J3KRR7J3KRR7innateimmuneresponseproteindeubiquitinationubiquitin-dependentproteincatabolicprocessWntsignalingpathway
nitric-oxide synthase (NADPH)
4.0
63
74
A0S0A6A0S0A6A0S0A6A0S0A6nitricoxidebiosyntheticprocess
Zinc finger protein SNAI1
3.6
42
86
SNAI1SNAI1O95863O95863aorticvalvemorphogenesiscartilagemorphogenesisepithelialcellmigrationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationhairfolliclemorphogenesisheterochromatinorganizationleft/rightpatternformationmesodermformationnegativeregulationofcelldifferentiationinvolvedinembryonicplacentadevelopmentnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvitaminDbiosyntheticprocessNotchsignalinginvolvedinheartdevelopmentosteoblastdifferentiationpositiveregulationofcellmigrationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionregulationofbicellulartightjunctionassemblyregulationoftranscriptionbyRNApolymeraseIIroofofmouthdevelopmenttrophoblastgiantcelldifferentiation
THO complex subunit 2
3.6
83
79
THOC2THOC3Q8NI27Q96J01generationofneuronsmRNAexportfromnucleusmRNAprocessingneurondevelopmentpoly(A)+mRNAexportfromnucleusRNAsplicingviralmRNAexportfromhostcellnucleus
Transportin-1
3.6
83
70
TNPO1TNPO1Q92973Q92973proteinimportintonucleus
UDP-glucose 6-dehydrogenase
3.6
98
69
UGDHUGDHO60701O60701carbohydratemetabolicprocesschondroitinsulfatebiosyntheticprocessgastrulationwithmouthformingsecondglycosaminoglycanbiosyntheticprocessheparansulfateproteoglycanbiosyntheticprocessneurondevelopmentproteinhexamerizationUDP-glucuronatebiosyntheticprocess
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
3.6
81
70
GFPT1GFPT1Q06210Q06210circadianregulationofgeneexpressionenergyreservemetabolicprocessfructose6-phosphatemetabolicprocessglutaminemetabolicprocessproteinN-linkedglycosylationUDP-N-acetylglucosaminebiosyntheticprocessUDP-N-acetylglucosaminemetabolicprocess
E3 ubiquitin-protein ligase RNF8
3.7
67
87
✔
RNF8RNF8O76064O76064cellcyclecelldivisioncellularresponsetoDNAdamagestimulusdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoininghistoneH2AK63-linkedubiquitinationhistoneH2AubiquitinationhistoneH2Bubiquitinationinterstrandcross-linkrepairisotypeswitchingnegativeregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationofDNArepairproteinautoubiquitinationproteinK48-linkedubiquitinationproteinK63-linkedubiquitinationproteinubiquitinationresponsetoionizingradiationspermDNAcondensationspermatiddevelopmentubiquitin-dependentproteincatabolicprocess
Proteasome subunit alpha type-3
3.6
74
74
✔
PSA3PSA3P25788P25788proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofendopeptidaseactivity
40S ribosomal protein S12
4.3
81
65
✔
RS12RS12P25398P25398cytoplasmictranslationpositiveregulationofcanonicalWntsignalingpathwaytranslation
Anaphase-promoting complex subunit 1
3.6
81
72
APC1APC1Q9H1A4Q9H1A4anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionmetaphase/anaphasetransitionofmitoticcellcycleproteinK11-linkedubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycle
Actin-binding LIM protein 2
3.6
44
90
ABLM2ABLM2Q6H8Q1Q6H8Q1cytoskeletonorganizationlamellipodiumassembly
Glycine receptor subunit alpha-2
3.6
59
77
GLRA2GLRA2P23416P23416cellularresponsetoaminoacidstimuluscellularresponsetoethanolcellularresponsetozincionchemicalsynaptictransmissionchloridetransmembranetransportiontransmembranetransportnervoussystemprocessneuropeptidesignalingpathwayregulationofmembranepotentialresponsetoaminoacidsignaltransductionsynaptictransmissionglycinergic
Ubiquitin carboxyl-terminal hydrolase 46
4.1
58
91
UBP46UBP46P62068P62068adultfeedingbehaviorbehavioralfearresponsebehavioralresponsetoethanolproteindeubiquitinationregulationofsynaptictransmissionGABAergicrightingreflexubiquitin-dependentproteincatabolicprocess
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3
3.8
75
85
ASAP3ASAP3Q6P9F4Q6P9F4cellmigrationpositiveregulationofGTPaseactivityregulationofstressfiberassembly
E3 ubiquitin-protein ligase UBR1
3.7
64
94
UBR1UBR1Q8IWV7Q8IWV7cellularresponsetoleucinenegativeregulationofTORsignalingproteinubiquitinationubiquitin-dependentproteincatabolicprocessviatheN-endrulepathway
Potassium voltage-gated channel subfamily D member 3
3.6
53
76
KCND3KCND3Q62897Q62897cellularresponsetoBMPstimulusmembranerepolarizationmembranerepolarizationduringventricularcardiacmusclecellactionpotentialpotassiumionexportacrossplasmamembranepotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofheartratebycardiacconductionregulationofiontransmembranetransportventricularcardiacmusclecellmembranerepolarization
S-methyl-5'-thioadenosine phosphorylase
3.6
79
71
MTAPMTAPQ13126Q13126L-methioninesalvagefrommethylthioadenosinemethylationnucleobase-containingcompoundmetabolicprocesspurineribonucleosidesalvageresponsetotestosterone
CST complex subunit STN1
3.6
67
73
STN1STN1Q9H668Q9H668negativeregulationoftelomeremaintenanceviatelomerasepositiveregulationofDNAreplicationtelomerecappingtelomeremaintenancetelomeremaintenanceviatelomerelengthening
Protein artemis
3.8
66
90
DCR1CDCR1CQ96SD1Q96SD1adaptiveimmuneresponseBcelldifferentiationdouble-strandbreakrepairvianonhomologousendjoininginterstrandcross-linkrepairprotectionfromnon-homologousendjoiningattelomereresponsetoionizingradiationV(D)Jrecombination
Lysine-specific demethylase 2A
3.6
43
91
KDM2AKDM2AQ9Y2K7Q9Y2K7chromatinorganizationcircadianregulationofgeneexpressiondouble-strandbreakrepairvianonhomologousendjoininghistoneH3-K36demethylationnegativeregulationoftranscriptionbycompetitivepromoterbindingproteindemethylationregulationofcircadianrhythmregulationoftranscriptionbyRNApolymeraseII
Anaphase-promoting complex subunit 11
3.8
59
89
APC11APC11Q9NYG5Q9NYG5anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionmitoticcellcyclepositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationproteinubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycleubiquitin-dependentproteincatabolicprocess
POZ-, AT hook-, and zinc finger-containing protein 1
3.7
34
88
PATZ1PATZ1Q9HBE1Q9HBE1malegonaddevelopmentnegativeregulationofDNA-templatedtranscriptionnegativeregulationofendothelialcellmigrationpositiveregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIspermatogenesisTcelldifferentiation
5-hydroxytryptamine (serotonin) receptor 3A
3.6
68
75
E9QLC0E9QLC0E9QLC0E9QLC0inorganiccationtransmembranetransport
LIM domain-containing protein 2
3.6
50
89
LIMD2LIMD2Q9BT23Q9BT23
G protein-coupled receptor kinase 5
3.6
92
68
GRK5GRK5P34947P34947adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayapoptoticprocessfatcelldifferentiationGprotein-coupledreceptorsignalingpathwaynegativeregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationproteinautophosphorylationproteinphosphorylationregulationofcellcycleregulationofGprotein-coupledreceptorsignalingpathwayregulationofsignaltransductiontachykininreceptorsignalingpathwayWntsignalingpathway
ADP-ribosylation factor GTPase-activating protein 3
3.6
55
81
ARFG3ARFG3Q9NP61Q9NP61COPIcoatingofGolgivesicleintracellularproteintransportproteinsecretionvesicle-mediatedtransport
Probable E3 ubiquitin-protein ligase IRF2BPL
3.8
53
87
I2BPLI2BPLQ9H1B7Q9H1B7developmentofsecondaryfemalesexualcharacteristicsnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Zinc finger protein with KRAB and SCAN domains 5
3.6
33
93
ZKSC5ZKSC5Q9Y2L8Q9Y2L8regulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
E3 ubiquitin-protein ligase Praja-1
3.9
38
84
PJA1PJA1Q8NG27Q8NG27proteincatabolicprocess
Tripartite motif-containing protein 54
3.7
54
88
TRI54TRI54Q9BYV2Q9BYV2celldifferentiationmicrotubule-basedprocessnegativeregulationofmicrotubuledepolymerizationproteinubiquitinationsignaltransduction
Histone-lysine N-methyltransferase SETMAR
3.8
62
88
SETMRSETMRQ53H47Q53H47cellpopulationproliferationchromatinorganizationDNAcatabolicprocessendonucleolyticDNAdouble-strandbreakprocessingDNAintegrationdouble-strandbreakrepairvianonhomologousendjoininghistoneH3-K36dimethylationhistoneH3-K4methylationmitoticDNAintegritycheckpointsignalingnegativeregulationofchromosomeorganizationnucleicacidphosphodiesterbondhydrolysispositiveregulationofDNAtopoisomerase(ATP-hydrolyzing)activitypositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningreplicationforkprocessing
Zinc finger protein 32
3.6
37
90
ZNF32ZNF32P17041P17041regulationoftranscriptionbyRNApolymeraseII
Dermatan-sulfate epimerase
3.6
42
81
DSEDSEQ9UL01Q9UL01chondroitinsulfatebiosyntheticprocesschondroitinsulfatemetabolicprocessdermatansulfatebiosyntheticprocessdermatansulfatemetabolicprocessheparansulfateproteoglycanbiosyntheticprocess
40S ribosomal protein S27
3.6
32
84
G1TZ76G1TZ76G1TZ76G1TZ76translation
Exosome complex exonuclease RRP44
3.6
48
82
RRP44RRP44Q9Y2L1Q9Y2L1CUTcatabolicprocessexonucleolyticcatabolismofdeadenylatedmRNARNAcatabolicprocessRNAprocessingrRNAcatabolicprocessrRNAprocessing
AN1-type zinc finger protein 1
3.4
48
90
ZFAN1ZFAN1Q8BFR6Q8BFR6cellularresponsetoarseniteionpositiveregulationofintracellularproteintransportstressgranuledisassembly
Retinoic acid receptor alpha
3.7
44
91
RARARARAP10276P10276apoptoticcellclearancecelldifferentiationcellularresponsetoestrogenstimuluscellularresponsetolipopolysaccharidecellularresponsetoretinoicacidchondroblastdifferentiationembryoniccamera-typeeyedevelopmentfacedevelopmentfemalepregnancygermcelldevelopmentglandularepithelialcelldevelopmentgrowthplatecartilagedevelopmenthippocampusdevelopmenthormone-mediatedsignalingpathwaylimbdevelopmentliverdevelopmentmRNAtranscriptionbyRNApolymeraseIImulticellularorganismgrowthnegativeregulationofcartilagedevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgranulocytedifferentiationnegativeregulationofmiRNAtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionneuraltubeclosurepositiveregulationofbindingpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-4productionpositiveregulationofinterleukin-5productionpositiveregulationofneurondifferentiationpositiveregulationofT-helper2celldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIprostateglanddevelopmentproteinphosphorylationregulationofapoptoticprocessregulationofhematopoieticprogenitorcelldifferentiationregulationofmyelinationregulationofsynapticplasticityresponsetocytokineresponsetoestradiolresponsetoethanolresponsetoretinoicacidresponsetovitaminAretinoicacidreceptorsignalingpathwaySertolicellfatecommitmenttracheacartilagedevelopmenturetericbuddevelopmentventricularcardiacmusclecelldifferentiation
DNA-directed RNA polymerase subunit
3.6
63
80
I3LJR4I3LJR4I3LJR4I3LJR4transcriptionbyRNApolymeraseII
Zinc finger protein 64
3.6
36
89
ZF64BZF64BQ9NPA5Q9NPA5mesenchymalcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpression
CXXC-type zinc finger protein 5
3.6
40
78
CXXC5CXXC5Q7LFL8Q7LFL8negativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofI-kappaBkinase/NF-kappaBsignaling
Ribonuclease P protein subunit p21
3.6
63
86
RPP21RPP21Q9H633Q9H633responsetoxenobioticstimulus"tRNA5-leaderremoval"tRNAprocessing
Zinc finger CCCH-type antiviral protein 1
3.7
35
93
✔
ZCCHVZCCHVQ7Z2W4Q7Z2W4defenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofmRNAcatabolicprocesspositiveregulationofRIG-IsignalingpathwaypositiveregulationoftypeIinterferonproductionresponsetovirus
PDZ and LIM domain protein 3
3.6
43
90
PDLI3PDLI3O70209O70209actincytoskeletonorganizationactinfilamentorganizationheartdevelopmentmusclestructuredevelopment
E3 ubiquitin-protein ligase RNF125
3.7
45
90
RN125RN125Q96EQ8Q96EQ8adaptiveimmuneresponsecellularresponsetoleukemiainhibitoryfactornegativeregulationofRIG-IsignalingpathwaynegativeregulationoftypeIinterferonproductionproteinpolyubiquitinationubiquitin-dependentproteincatabolicprocess
SP100 nuclear antigen
3.8
55
89
H0Y4R8H0Y4R8H0Y4R8H0Y4R8
Zinc finger CW-type PWWP domain protein 1
3.6
48
89
ZCPW1ZCPW1Q9H0M4Q9H0M4celldifferentiationhomologouschromosomepairingatmeiosismeiosisIpositiveregulationofDNArecombinationpositiveregulationofdouble-strandbreakrepairspermatogenesis
Copper-transporting ATPase 1
3.6
44
80
ATP7AATP7AQ04656Q04656bloodvesseldevelopmentbloodvesselremodelingcartilagedevelopmentcatecholaminemetabolicprocesscellularcopperionhomeostasiscellularresponsetoaminoacidstimuluscellularresponsetoantibioticcellularresponsetocadmiumioncellularresponsetocobaltioncellularresponsetocopperioncellularresponsetohypoxiacellularresponsetoironioncellularresponsetoleadioncellularresponsetoplatelet-derivedgrowthfactorstimuluscentralnervoussystemneurondevelopmentcerebellarPurkinjecelldifferentiationcollagenfibrilorganizationcopperionexportcopperionhomeostasiscopperionimportcopperiontransportdetoxificationofcopperiondopaminemetabolicprocesselasticfiberassemblyelastinbiosyntheticprocessepinephrinemetabolicprocessextracellularmatrixorganizationfemalepregnancyhairfolliclemorphogenesisinuteroembryonicdevelopmentlactationliverdevelopmentlocomotorybehaviorlungalveolusdevelopmentmitochondrionorganizationnegativeregulationofironiontransmembranetransportneuronprojectionmorphogenesisnorepinephrinemetabolicprocesspeptidyl-lysinemodificationpigmentationpositiveregulationofcatalyticactivitypositiveregulationofcellsizepositiveregulationofepithelialcellproliferationpositiveregulationoflamellipodiumassemblypositiveregulationofmelaninbiosyntheticprocesspositiveregulationofresponsetowoundingpositiveregulationoftyrosinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellmigrationpyramidalneurondevelopmentregulationofcytochrome-coxidaseactivityregulationofgeneexpressionregulationofoxidativephosphorylationremovalofsuperoxideradicalsresponsetoiron(III)ionresponsetomanganeseionresponsetozincionserotoninmetabolicprocessskindevelopmentT-helpercelldifferentiationtryptophanmetabolicprocess
PHD finger protein 21A
3.8
57
90
PF21APF21AQ96BD5Q96BD5chromatinorganizationnegativeregulationoftranscriptionbyRNApolymeraseII
RelA-associated inhibitor
3.6
75
86
IASPPIASPPQ8WUF5Q8WUF5apoptoticprocesscardiacmusclecontractioncardiacrightventriclemorphogenesisembryoniccamera-typeeyedevelopmenthaircyclemulticellularorganismgrowthmulticellularorganismalhomeostasisnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcelldifferentiationpost-embryonicdevelopmentregulationoftranscriptionbyRNApolymeraseIIventricularcardiacmuscletissuedevelopment
Abscission/NoCut checkpoint regulator
3.6
59
87
ANCHRANCHRQ9DAZ9Q9DAZ9abscissioncelldivisionmitoticcytokinesischeckpointsignalingnegativeregulationofcytokinesis
WD repeat-containing protein 20
3.6
70
76
L8I535L8I535L8I535L8I535
Metal-response element-binding transcription factor 2
3.7
49
85
✔
MTF2MTF2Q9Y483Q9Y483cellularresponsetoleukemiainhibitoryfactorchromatinorganizationnegativeregulationofhistoneH3-K27methylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofhistoneH3-K27methylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionsegmentspecificationstemcelldifferentiationstemcellpopulationmaintenance
Cell division control protein 45 homolog
3.6
65
76
CDC45CDC45O75419O75419DNAreplicationcheckpointsignalingDNAreplicationinitiationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviabreak-inducedreplicationmitoticDNAreplicationpreinitiationcomplexassembly
RING finger and CHY zinc finger domain-containing protein 1
3.7
53
90
ZN363ZN363Q96PM5Q96PM5error-freetranslesionsynthesispositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteinautoubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
E3 ubiquitin-protein ligase ZSWIM2
3.6
47
87
ZSWM2ZSWM2Q8NEG5Q8NEG5apoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsproteinpolyubiquitination
Lysine-specific demethylase 5D
3.6
43
88
KDM5DKDM5DQ9BY66Q9BY66chromatinremodelinghistonelysinedemethylationregulationofandrogenreceptorsignalingpathwayTcellantigenprocessingandpresentation
Dystrobrevin alpha
3.6
46
84
DTNADTNAQ9Y4J8Q9Y4J8chemicalsynaptictransmissionneuromuscularsynaptictransmissionsignaltransductionstriatedmusclecontractionsynapticsignaling
Polycomb group RING finger protein 5
3.9
51
90
PCGF5PCGF5Q86SE9Q86SE9histoneH2A-K119monoubiquitinationinactivationofXchromosomebygenomicimprintingpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Mediator of RNA polymerase II transcription subunit 20
2.0
96
79
MED20MED20Q9R0X0Q9R0X0positiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinubiquitinationregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblyskeletalmusclecelldifferentiation
Protein kinase C theta type
3.8
51
91
KPCTKPCTQ04759Q04759axonguidanceCD4-positivealpha-betaTcellproliferationcellchemotaxisFc-epsilonreceptorsignalingpathwayinflammatoryresponseintracellularsignaltransductionmembraneproteinectodomainproteolysisnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofTcellapoptoticprocesspeptidyl-serinephosphorylationpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofinterleukin-17productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellactivationpositiveregulationofT-helper17typeimmuneresponsepositiveregulationofT-helper2cellactivationpositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomeraseproteinphosphorylationregulationofcellgrowthregulationofDNA-templatedtranscriptionregulationofplateletaggregation
Inhibitor of growth protein 3
3.6
54
90
ING3ING3Q9NXR8Q9NXR8chromatinorganizationhistoneacetylationhistoneH2AacetylationhistoneH4acetylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofapoptoticprocessregulationofcellcycleregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepair
Mediator of RNA polymerase II transcription subunit 16
3.6
81
67
✔
MED16MED16Q9Y2X0Q9Y2X0positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseII
ADP-ribosylation factor GTPase-activating protein 2
3.6
64
74
ARFG2ARFG2Q8N6H7Q8N6H7COPIcoatingofGolgivesicleproteintransport
Formimidoyltransferase-cyclodeaminase
3.6
97
66
FTCDFTCDP53603P53603histidinecatabolicprocesshistidinecatabolicprocesstoglutamateandformamidehistidinecatabolicprocesstoglutamateandformate
Ferrochelatase
3.7
68
80
Q7KZA3Q7KZA3Q7KZA3Q7KZA3hemebiosyntheticprocess
RNA-binding protein 5
3.9
52
89
RBM5RBM5P52756P52756apoptoticprocessmRNAsplicingviaspliceosomenegativeregulationofcellpopulationproliferationpositiveregulationofapoptoticprocessregulationofalternativemRNAsplicingviaspliceosomeRNAprocessingspliceosomalcomplexassembly
Probable cytosolic iron-sulfur protein assembly protein CIAO1
4.0
67
71
✔
CIAO1CIAO1O76071O76071chromosomesegregationiron-sulfurclusterassemblypositiveregulationofcellpopulationproliferationproteinmaturationbyiron-sulfurclustertransferregulationoftranscriptionbyRNApolymeraseII
Krueppel-like factor 10
3.6
42
83
KLF10KLF10Q13118Q13118bonemineralizationcell-cellsignalingcellularresponsetostarvationcircadianrhythmnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcircadianrhythmregulationoftranscriptionbyRNApolymeraseIIsomaticstemcellpopulationmaintenance
E3 ubiquitin-protein ligase TRIM41
3.7
54
87
TRI41TRI41Q8WV44Q8WV44cellularresponsetolipopolysaccharidecellularresponsetomuramyldipeptidedefenseresponsetoviruspositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftypeIinterferon-mediatedsignalingpathwayproteinmonoubiquitinationproteinubiquitination
YY1-associated factor 2
3.8
49
92
YAF2YAF2Q8IY57Q8IY57negativeregulationofDNA-templatedtranscriptionpositiveregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscription
Zinc finger protein 692
3.6
38
87
ZN692ZN692Q9BU19Q9BU19negativeregulationoftranscriptionbyRNApolymeraseIIregulationofgluconeogenesisregulationoftranscriptionbyRNApolymeraseII
Telomere zinc finger-associated protein
3.8
41
91
TZAPTZAPQ99K15Q99K15positiveregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIItelomeremaintenanceviatelomerelengthening
E3 ubiquitin-protein ligase TRIM34
3.8
43
90
TRI34TRI34Q9BYJ4Q9BYJ4defenseresponsetovirusinnateimmuneresponsepositiveregulationofautophagypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinpolyubiquitinationproteinubiquitinationregulationofgeneexpressionregulationofproteinlocalizationregulationofviralentryintohostcell
Tripartite motif-containing protein 29
3.6
53
88
TRI29TRI29Q14134Q14134innateimmuneresponsenegativeregulationofproteinlocalizationtonucleusnegativeregulationoftranscriptionbyRNApolymeraseII
Zinc finger and BTB domain-containing protein 43
3.7
36
92
ZBT43ZBT43O43298O43298regulationoftranscriptionbyRNApolymeraseII
MORC family CW-type zinc finger protein 4
3.9
49
85
MORC4MORC4Q8TE76Q8TE76
Teashirt homolog 3
3.6
41
87
TSH3TSH3Q63HK5Q63HK5long-termsynapticpotentiationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofsynaptictransmissionglutamatergicregulationofrespiratorygaseousexchangebynervoussystemprocessregulationoftranscriptionbyRNApolymeraseII
Peroxisome proliferator-activated receptor delta
3.8
41
88
PPARDPPARDQ03181Q03181adiposetissuedevelopmentapoptoticprocessapoptoticsignalingpathwayaxonensheathmentcelldifferentiationcellpopulationproliferationcell-substrateadhesioncellularresponsetohypoxiacellularresponsetolipopolysaccharidecholesterolmetabolicprocessdecidualizationembryoimplantationfatcellproliferationfattyacidbeta-oxidationfattyacidcatabolicprocessfattyacidmetabolicprocessfattyacidtransportgenerationofprecursormetabolitesandenergyglucosemetabolicprocessglucosetransmembranetransportheartdevelopmenthormone-mediatedsignalingpathwaykeratinocytemigrationkeratinocyteproliferationlipidmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcholesterolstoragenegativeregulationofcollagenbiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationnegativeregulationofinflammatoryresponsenegativeregulationofmiRNAtranscriptionnegativeregulationofmyoblastdifferentiationnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIphosphatidylinositol3-kinasesignalingphospholipidbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofepidermisdevelopmentpositiveregulationoffatcelldifferentiationpositiveregulationoffatcellproliferationpositiveregulationoffattyacidmetabolicprocesspositiveregulationoffattyacidoxidationpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmyoblastproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofskeletalmuscletissueregenerationpositiveregulationoftranscriptionbyRNApolymeraseIIproteoglycanmetabolicprocessregulationoflipidmetabolicprocessregulationofskeletalmusclesatellitecellproliferationregulationoftranscriptionbyRNApolymeraseIIresponsetoactivityresponsetoglucoseresponsetolipidresponsetovitaminAvasodilationvitaminAmetabolicprocesswoundhealing
Zinc finger protein 224
3.7
36
88
ZN224ZN224Q9NZL3Q9NZL3negativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Tyrosine-protein kinase BAZ1B
3.8
45
89
BAZ1BBAZ1BQ9UIG0Q9UIG0cellularresponsetoDNAdamagestimuluschromatinremodelingnegativeregulationofmitoticchromosomecondensationpositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpost-translationalproteinmodificationregulationofresponsetoDNAdamagestimulusregulationoftranscriptionbyRNApolymeraseII
Krueppel-like factor 15
3.6
40
81
KLF15KLF15Q9UIH9Q9UIH9cardiacmusclehypertrophyinresponsetostresscellularglucosehomeostasiscellularresponsetopeptideglialcelldifferentiationnegativeregulationofpeptidyl-lysineacetylationpodocytedifferentiationpositiveregulationofglucoseimportpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIregulationofWntsignalingpathwayresponsetoinsulin
HLA class II histocompatibility antigen, DR alpha chain
3.6
76
73
DRADRAP01903P01903adaptiveimmuneresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassIIcognitionimmuneresponsemyeloiddendriticcellantigenprocessingandpresentationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofCD4-positivealpha-betaTcellactivationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationpositiveregulationofmemoryTcelldifferentiationpositiveregulationofTcellactivationpositiveregulationofTcellmediatedcytotoxicityregulationofT-helpercelldifferentiation
Zinc finger HIT domain-containing protein 3
3.6
84
72
ZNHI3NUFP1Q15649Q9UHK0boxC/DsnoRNPassemblymaturationofLSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)regulationofDNA-templatedtranscriptionsnoRNAlocalizationpositiveregulationoftranscriptionbyRNApolymeraseIIRNAprocessing
RING finger protein 24
3.7
44
88
RNF24RNF24Q9Y225Q9Y225
Zinc finger protein 512B
3.8
48
89
Z512BZ512BQ96KM6Q96KM6negativeregulationofmiRNAtranscription
Zinc finger HIT domain-containing protein 2
3.8
53
90
ZNHI2ZNHI2Q9UHR6Q9UHR6
E3 ubiquitin-protein ligase RNF126
3.7
50
87
RN126RN126Q9BV68Q9BV68cytoplasmproteinqualitycontrolbytheubiquitin-proteasomesystemnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinK63-linkedubiquitinationproteinmonoubiquitinationregulationofcellpopulationproliferationretrogradetransportendosometoGolgiubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Krueppel-like factor 5
3.7
37
89
KLF5KLF5Q13887Q13887angiogenesiscell-cellsignalingviaexosomecellularresponsetoleukemiainhibitoryfactorintestinalepithelialcelldevelopmentmicrovillusassemblymyotubedifferentiationinvolvedinskeletalmuscleregenerationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoffatcelldifferentiationpositiveregulationofmiRNAtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbytranscriptionfactorlocalizationregulationofmicrovillusassemblyregulationoftranscriptionbyRNApolymeraseIIsatellitecellactivationinvolvedinskeletalmuscleregenerationskeletalmusclesatellitecelldifferentiation
Suppression of tumorigenicity 18 protein
3.7
48
90
ST18ST18O60284O60284interleukin-1-mediatedsignalingpathwayinterleukin-6-mediatedsignalingpathwaynegativeregulationofcellpopulationproliferationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIItumornecrosisfactor-mediatedsignalingpathway
Zinc finger and BTB domain-containing protein 17
3.6
37
88
ZBT17ZBT17Q13105Q13105ectodermdevelopmentG1toG0transitiongastrulationwithmouthformingsecondnegativeregulationofcellcyclenegativeregulationofcellpopulationproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Transcription elongation factor SPT6
4.0
63
80
SPT6HSPT6HQ7KZ85Q7KZ85blastocystformationmRNAprocessingmRNAtranscriptionbyRNApolymeraseIImRNAtransportnucleosomeorganizationpositiveregulationoftranscriptionelongationbyRNApolymeraseIIregulationofisotypeswitchingregulationofmRNAexportfromnucleusregulationofmRNAprocessingregulationofmusclecelldifferentiationRNAsplicingtranscriptionelongationbyRNApolymeraseIIpromotertranscriptionelongation-coupledchromatinremodeling
Endothelial transcription factor GATA-2
3.7
61
84
GATA2GATA2P23769P23769brownfatcelldifferentiationcelldifferentiationinhindbraincellfatecommitmentcellfatedeterminationcentralnervoussystemneurondevelopmentcochleadevelopmentcommitmentofneuronalcelltospecificneurontypeinforebraindefinitivehemopoiesisembryonicplacentadevelopmenteosinophilfatecommitmentGABAergicneurondifferentiationglandularepithelialcellmaturationhematopoieticprogenitorcelldifferentiationhematopoieticstemcellhomeostasishomeostasisofnumberofcellswithinatissueinnerearmorphogenesisnegativeregulationofbrownfatcelldifferentiationnegativeregulationofendothelialcellapoptoticprocessnegativeregulationoffatcelldifferentiationnegativeregulationoffatcellproliferationnegativeregulationofgeneexpressionnegativeregulationofhematopoieticprogenitorcelldifferentiationnegativeregulationofmacrophagedifferentiationnegativeregulationofneuralprecursorcellproliferationnegativeregulationofneuroblastproliferationnegativeregulationofNotchsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIneuroblastproliferationneuronmigrationphagocytosispositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofmastcelldegranulationpositiveregulationofmegakaryocytedifferentiationpositiveregulationofmiRNAtranscriptionpositiveregulationofneurondifferentiationpositiveregulationofphagocytosispositiveregulationofphagocytosisengulfmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofforebrainneurondifferentiationregulationofhistoneacetylationregulationofprimitiveerythrocytedifferentiationresponsetolipidsemicircularcanaldevelopmentsomaticstemcellpopulationmaintenancethyroid-stimulatinghormone-secretingcelldifferentiationtranscriptionbyRNApolymeraseIIurogenitalsystemdevelopmentvascularwoundhealingventralspinalcordinterneurondifferentiation
Tetratricopeptide repeat protein 21B
4.2
72
75
TT21BTT21BQ7Z4L5Q7Z4L5BergmannglialcelldifferentiationcerebellarPurkinjecelldifferentiationciliumassemblyforebraindorsal/ventralpatternformationintraciliaryretrogradetransportnegativeregulationofeatingbehaviorpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofgeneexpressionproteinlocalizationtociliumproteinlocalizationtonon-motileciliumregulationofintraciliaryretrogradetransportregulationofsmoothenedsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIsmoothenedsignalingpathwayventricularsystemdevelopment
Paxillin
3.7
41
87
PAXIPAXIP49023P49023celladhesioncellmigrationcellularresponsetoreactiveoxygenspeciesendothelialcellmigrationgrowthhormonereceptorsignalingpathwaypositiveregulationofstressfiberassemblysignalcomplexassemblysignaltransductionsubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetareceptorsignalingpathway
Ubiquitin carboxyl-terminal hydrolase 16
3.7
77
87
✔
UBP16UBP16Q9Y5T5Q9Y5T5celldivisioncellularresponsetoDNAdamagestimuluschromatinorganizationhistonedeubiquitinationhistoneH2AK63-linkeddeubiquitinationmitoticcellcyclemitoticnucleardivisionmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationalelongationproteindeubiquitinationproteinhomotetramerizationregulationofcellcycleregulationoftranscriptionbyRNApolymeraseIIubiquitin-dependentproteincatabolicprocess
CDK-activating kinase assembly factor MAT1
3.8
57
80
MAT1MAT1P51948P51948adultheartdevelopmentDNArepairG1/StransitionofmitoticcellcyclenegativeregulationofapoptoticprocessnegativeregulationofDNAhelicaseactivitynucleotide-excisionrepairpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofsmoothmusclecellproliferationprotein-containingcomplexassemblyregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofG1/StransitionofmitoticcellcycleregulationoftranscriptionbyRNApolymeraseIIresponsetocalciumiontranscriptionbyRNApolymeraseIIventricularsystemdevelopment
Pogo transposable element with ZNF domain
3.7
40
91
POGZPOGZQ7Z3K3Q7Z3K3celldivisionDNArecombinationDNArepairkinetochoreassemblymitoticsisterchromatidcohesionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpression
Beta-chimaerin
3.8
56
80
CHIOCHIOP52757P52757positiveregulationofGTPaseactivityregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionsignaltransduction
Growth arrest and DNA damage-inducible protein GADD45 alpha
4.4
54
73
GA45AGA45AP24522P24522apoptoticprocesscellularresponsetoionizingradiationcellularresponsetomechanicalstimuluscentrosomecycleDNArepairnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofpeptidyl-serinephosphorylationofSTATproteinnegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationofJNKcascadepositiveregulationofp38MAPKcascadepositiveregulationofreactiveoxygenspeciesmetabolicprocessregulationofcellcycleregulationofcyclin-dependentproteinserine/threoninekinaseactivitysignaltransductioninresponsetoDNAdamage
Protein SCO2 homolog, mitochondrial
3.7
51
82
SCO2SCO2O43819O43819cellularcopperionhomeostasiseyedevelopmentinuteroembryonicdevelopmentmitochondrialcytochromecoxidaseassemblymusclesystemprocessrespiratoryelectrontransportchainresponsetoactivity
Tripartite motif-containing protein 66
3.7
42
88
TRI66TRI66O15016O15016
Zinc finger FYVE domain-containing protein 16
3.8
48
87
ZFY16ZFY16Q7Z3T8Q7Z3T8endosomaltransportproteintargetingtolysosomeregulationofendocytosissignaltransductionvesicleorganization
DNA excision repair protein ERCC-8
3.7
57
77
ERCC8ERCC8Q13216Q13216cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviaclassicalnonhomologousendjoiningpositiveregulationofDNArepairproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinpolyubiquitinationregulationoftranscription-couplednucleotide-excisionrepairresponsetooxidativestressresponsetoUVresponsetoX-raysinglestrandbreakrepairtranscription-couplednucleotide-excisionrepair
Ataxin-7-like protein 3
3.7
46
85
AT7L3AT7L3Q14CW9Q14CW9chromatinorganizationhistonedeubiquitinationhistoneH3acetylationhistonemonoubiquitinationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseII
PR domain zinc finger protein 1
3.7
84
70
PRDM1PRDM1O75626O75626adaptiveimmuneresponseaortadevelopmentarterymorphogenesiscellfatecommitmentcoronaryvasculaturedevelopmenteyephotoreceptorcelldevelopmentgermcelldevelopmentheartvalvedevelopmentinnateimmuneresponseintestinalepithelialcelldevelopmentkidneydevelopmentmaternalplacentadevelopmentmorphogenesisofabranchingstructurenegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-argininemethylationpositiveregulationofgeneexpressionpost-embryonicdevelopmentregulationofcellpopulationproliferationregulationofextrathymicTcelldifferentiationregulationofgeneexpressionregulationofnaturalkillercelldifferentiationregulationofNKTcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIresponsetoradiationretinalbipolarneurondifferentiationsebumsecretingcellproliferationtrophoblastgiantcelldifferentiationventricularseptumdevelopment
TNF receptor-associated factor 4
3.8
48
91
TRAF4TRAF4Q9BUZ4Q9BUZ4activationofNF-kappaB-inducingkinaseactivityapoptoticprocessinnateimmuneresponsepositiveregulationofJNKcascadepositiveregulationofproteinkinaseactivityproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingrespiratorygaseousexchangebyrespiratorysystemrespiratorytubedevelopment
Somatostatin receptor type 2
3.7
70
75
SSR2SSR2P30874P30874adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycellularresponsetoestradiolstimuluscellularresponsetoglucocorticoidstimuluscerebellumdevelopmentforebraindevelopmentGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernegativeregulationofcellpopulationproliferationneuropeptidesignalingpathwayperistalsisregulationofmusclecontractionresponsetostarvationspermatogenesis
Diphthamide biosynthesis protein 3
3.8
48
90
DPH3DPH3Q8K0W9Q8K0W9negativeregulationofproteinsecretionpeptidyl-diphthamidebiosyntheticprocessfrompeptidyl-histidinepositiveregulationofbindingtRNAwobblebase5-methoxycarbonylmethyl-2-thiouridinylationtRNAwobbleuridinemodification
Protein unc-80 homolog
3.9
50
93
UNC80UNC80B8XCJ6B8XCJ6cationhomeostasis
E3 ubiquitin-protein ligase Hakai
3.7
38
90
HAKAIHAKAIQ9JIY2Q9JIY2cell-celladhesionmRNAmethylationnegativeregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofendocytosisproteinubiquitinationregulationofcelladhesion
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
3.9
57
81
RPAP2RPAP2Q8IXW5Q8IXW5dephosphorylationofRNApolymeraseIIC-terminaldomainsnRNAtranscription
Mediator of RNA polymerase II transcription subunit 27
3.7
49
84
MED27MED27Q6P2C8Q6P2C8positiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblysomaticstemcellpopulationmaintenancetranscriptioninitiationatRNApolymeraseIIpromoter
Myelin transcription factor 1
3.2
49
86
MYT1MYT1Q8CFC2Q8CFC2celldifferentiationcellularglucosehomeostasisdiaphragmdevelopmentendocrinepancreasdevelopmentnegativeregulationofgeneexpressionnervoussystemdevelopmentpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicdevelopmentregulationofhormonemetabolicprocessregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusregulationoftranscriptionbyRNApolymeraseII
PHD finger protein 13
3.9
42
90
PHF13PHF13Q86YI8Q86YI8celldivisionchromatinorganizationchromosomesegregationmitoticcellcyclemitoticchromosomecondensation
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
3.7
75
72
A0A6P3EI17A0A836CQA7A0A6P3EI17A0A836CQA7
CWF19-like protein 2
3.7
86
66
C19L2C19L2Q2TBE0Q2TBE0mRNAsplicingviaspliceosome
Nuclear receptor subfamily 5 group A member 2
3.8
44
88
NR5A2NR5A2O00482O00482acinarcelldifferentiationbileacidmetabolicprocesscalcineurin-mediatedsignalingcellularresponsetoleukemiainhibitoryfactorcholesterolhomeostasisembryodevelopmentendinginbirthoregghatchinghomeostaticprocesshormone-mediatedsignalingpathwaypancreasmorphogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofviralgenomereplicationregulationofcellpopulationproliferationregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIItissuedevelopment
Histone acetyltransferase KAT6B
3.7
56
91
KAT6BKAT6BQ8WYB5Q8WYB5histoneH3acetylationnegativeregulationofDNA-templatedtranscriptionnucleosomeassemblypositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofdevelopmentalprocessregulationofDNA-templatedtranscriptionregulationofhemopoiesis
DNA-directed RNA polymerase subunit
4.4
46
82
A0A480TA59A0A480TA59A0A480TA59A0A480TA59transcriptionbyRNApolymeraseII
Pre-mRNA-splicing factor CWC22 homolog
3.7
91
69
CWC22CWC22Q9HCG8Q9HCG8mRNAsplicingviaspliceosomeregulationofmRNAsplicingviaspliceosome
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
4.0
74
81
ACAP1ACAP1Q15027Q15027proteintransport
Histone-lysine N-methyltransferase KMT5C
3.8
55
75
KMT5CKMT5CQ86Y97Q86Y97chromatinorganizationDNArepairhistoneH4-K20dimethylationhistoneH4-K20trimethylationpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationofisotypeswitching
Ubiquitin carboxyl-terminal hydrolase 20
3.7
57
80
UBP20UBP20Q9Y2K6Q9Y2K6endocytosisproteindeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitinationregulationofGprotein-coupledreceptorsignalingpathwayubiquitin-dependentproteincatabolicprocess
Synaptotagmin-like protein 4
3.3
49
90
SYTL4SYTL4Q96C24Q96C24exocytosisinsulinsecretionintracellularproteintransportlysosomelocalizationmultivesicularbodysortingpathwaynegativeregulationofinsulinsecretionplasmamembranerepairpositiveregulationofexocytosispositiveregulationofproteinsecretionregulationofplasmamembranerepair
Zinc finger protein 346
3.7
44
87
ZN346ZN346Q9UL40Q9UL40
Calcium/calmodulin-dependent protein kinase kinase 1
3.7
75
75
KKCC1KKCC1Q8N5S9Q8N5S9intracellularsignaltransductionpositiveregulationofproteinkinaseactivityproteinphosphorylation
Ubiquitin carboxyl-terminal hydrolase MINDY-2
3.7
87
65
MINY2MINY2Q8NBR6Q8NBR6proteinK48-linkeddeubiquitination
Replication factor C subunit 3
3.7
71
74
✔
RFC3RFC3P40938P40938DNAduplexunwindingDNArepairDNAreplicationDNAstrandelongationinvolvedinDNAreplicationDNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivityresponsetoorganophosphorus
LIM/homeobox protein Lhx3
3.8
40
83
LHX3LHX3P50481P50481apoptoticprocessdorsal/ventralpatternformationinnereardevelopmentlungdevelopmentmedialmotorcolumnneurondifferentiationmotorneuronaxonguidancenegativeregulationofapoptoticprocessneurondifferentiationpituitaryglanddevelopmentplacentadevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIprolactinsecretingcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIsomatotropinsecretingcelldifferentiationspinalcordassociationneurondifferentiationspinalcordmotorneuroncellfatespecificationthyroid-stimulatinghormone-secretingcelldifferentiationventralspinalcordinterneuronspecification
Serine dehydratase-like
3.7
103
62
SDSLSDSLQ96GA7Q96GA7isoleucinebiosyntheticprocessL-serinecatabolicprocesslipidmetabolicprocessthreoninecatabolicprocess
Zinc finger protein DPF3
3.8
52
98
DPF3DPF3Q92784Q92784chromatinremodelingmuscleorgandevelopmentnegativeregulationofDNA-templatedtranscriptionnervoussystemdevelopmentpositiveregulationofcelldifferentiationpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
E3 ubiquitin-protein ligase MIB1
3.7
59
83
✔
MIB1MIB1Q86YT6Q86YT6bloodvesseldevelopmentendocytosisheartloopinginuteroembryonicdevelopmentnegativeregulationofneurondifferentiationneuraltubeformationneurondifferentiationNotchsignalingpathwaypositiveregulationofendocytosisproteinubiquitinationsomitogenesisubiquitin-dependentproteincatabolicprocess
mRNA decay activator protein ZFP36L2
3.7
42
89
TISDTISDP47974P47974"3-UTR-mediatedmRNAdestabilization"cellularresponsetoepidermalgrowthfactorstimuluscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetoglucocorticoidstimuluscellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactordefinitivehemopoiesisERK1andERK2cascadehemopoiesismRNAcatabolicprocessnegativeregulationoffatcelldifferentiationnegativeregulationofmitoticcellcyclephasetransitionnegativeregulationofstemcelldifferentiationnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecayregulationofBcelldifferentiationregulationofmRNAstabilityresponsetowoundingsomaticstemcelldivisionsomaticstemcellpopulationmaintenanceTcelldifferentiationinthymus
Cysteine and glycine-rich protein 3
3.7
43
89
CSRP3CSRP3P50461P50461actincytoskeletonorganizationcardiacmusclecontractioncardiacmusclehypertrophycardiacmuscletissuedevelopmentcardiacmyofibrilassemblycellularcalciumionhomeostasisdetectionofmusclestretchglucosehomeostasisinflammatoryresponseinsulinreceptorsignalingpathwaymusclecellcellularhomeostasismuscletissuedevelopmentnegativeregulationofactinfilamentseveringnegativeregulationofmyoblastdifferentiationpositiveregulationofactinfilamentseveringpositiveregulationofmyoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinkinaseCsignalingproteinlocalizationtoorganelleregulationofproteinlocalizationtoplasmamembraneregulationoftheforceofheartcontractionsarcomereorganizationskeletalmuscletissuedevelopmentT-tubuleorganization
Trifunctional purine biosynthetic protein adenosine-3
4.1
73
75
PUR2PUR2P22102P22102"denovoAMPbiosyntheticprocess""denovoIMPbiosyntheticprocess""denovoXMPbiosyntheticprocess"adeninebiosyntheticprocessbrainstemdevelopmentcerebellumdevelopmentcerebralcortexdevelopmentglycinemetabolicprocessGMPbiosyntheticprocesspurinenucleotidebiosyntheticprocesspurineribonucleosidemonophosphatebiosyntheticprocessresponsetoinorganicsubstanceresponsetoorganicsubstancetetrahydrofolatebiosyntheticprocess
Inactive histone-lysine N-methyltransferase 2E
3.9
66
91
KMT2EKMT2EQ8IZD2Q8IZD2cellcyclechromatinorganizationDNAmethylationerythrocytedifferentiationneutrophilactivationneutrophilmediatedimmunitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofG1/StransitionofmitoticcellcycleregulationofDNA-templatedtranscriptionregulationofhistoneacetylation
tRNA pseudouridine synthase Pus10
4.0
nan
85
PUS10PUS10Q3MIT2Q3MIT2primarymiRNAprocessingtRNApseudouridinesynthesis
Nuclear receptor subfamily 6 group A member 1
3.9
42
90
NR6A1NR6A1Q64249Q64249celldifferentiationgametegenerationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIspermatogenesis
FLYWCH-type zinc finger-containing protein 1
3.7
61
83
FWCH1FWCH1Q4VC44Q4VC44cellularresponsetoDNAdamagestimulusnegativeregulationoftranscriptionbyRNApolymeraseII
Autoimmune regulator
3.7
44
92
AIREAIREO43918O43918centraltoleranceinductiontoselfantigenhumoralimmuneresponseimmuneresponsenegativethymicTcellselectionperipheralTcelltoleranceinductionpositiveregulationofchemokineproductionpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationofthymocytemigrationthymusepitheliummorphogenesistranscriptionbyRNApolymeraseII
CDGSH iron-sulfur domain-containing protein 3, mitochondrial
3.6
56
83
CISD3CISD3P0C7P0P0C7P0proteinmaturationby2Fe-2Sclustertransfer
Ubiquitin carboxyl-terminal hydrolase 33
3.9
40
85
UBP33UBP33Q8TEY7Q8TEY7axonguidancecellmigrationcellularresponsetostarvationcentrosomeduplicationendocytosisnegativeregulationofproteinbindingpositiveregulationofproteinbindingproteindeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitinationproteinstabilizationregulationofautophagyregulationofGprotein-coupledreceptorsignalingpathwayubiquitin-dependentproteincatabolicprocess
Ubiquitin carboxyl-terminal hydrolase 35
3.8
37
88
UBP35UBP35Q9P2H5Q9P2H5proteindeubiquitinationubiquitin-dependentproteincatabolicprocess
SUMO-specific isopeptidase USPL1
3.7
45
87
USPL1USPL1Q5W0Q7Q5W0Q7CajalbodyorganizationcellpopulationproliferationproteindesumoylationsnRNAtranscription
Kinase suppressor of Ras 1
2.5
45
87
KSR1KSR1Q61097Q61097cAMP-mediatedsignalingpositiveregulationofMAPKcascadeproteinphosphorylationRasproteinsignaltransductionregulationofcellpopulationproliferationregulationofMAPkinaseactivitysignaltransduction
GTP-binding protein Di-Ras2
3.7
48
80
DIRA2DIRA2Q96HU8Q96HU8signaltransduction
Regulating synaptic membrane exocytosis protein 2
3.8
52
91
RIMS2RIMS2Q9JIS1Q9JIS1adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycalciumion-regulatedexocytosisofneurotransmittercalcium-ionregulatedexocytosiscelldifferentiationestablishmentoflocalizationincellexocytosisinsulinsecretionintracellularproteintransportmaintenanceofpresynapticactivezonestructureneurotransmittersecretionpositiveregulationofdendriteextensionpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofgeneexpressionpositiveregulationofinhibitorypostsynapticpotentialpositiveregulationofsynaptictransmissionregulationofcalcium-dependentactivationofsynapticvesiclefusionregulationofexocytosisregulationofmembranepotentialregulationofsynapticplasticityspontaneousneurotransmittersecretionsynapticvesicledockingsynapticvesiclepriming
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
3.7
58
78
AGAP2AGAP2Q99490Q99490actincytoskeletonorganizationactivationofGTPaseactivityendosomaltransportnegativeregulationofneuronapoptoticprocessnegativeregulationofproteincatabolicprocesspositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofproteinkinaseactivityproteintransport
Centrosomal protein of 104 kDa
4.0
52
86
CE104CE104O60308O60308
Polycystin-1
3.7
73
75
PKD1PKD1P98161P98161anatomicalstructuremorphogenesisbranchingmorphogenesisofanepithelialtubecalciumiontransmembranetransportcalciumiontransportcalcium-independentcell-matrixadhesioncartilagecondensationcartilagedevelopmentcell-cellsignalingbywntcell-matrixadhesioncytoplasmicsequesteringoftranscriptionfactordetectionofmechanicalstimulusdigestivetractdevelopmentembryonicplacentadevelopmentestablishmentofepithelialcellpolaritygenitaliadevelopmentheartdevelopmenthomophiliccelladhesionviaplasmamembraneadhesionmoleculesinuteroembryonicdevelopmentkidneydevelopmentliverdevelopmentlungepitheliumdevelopmentlymphvesselmorphogenesismesonephricductdevelopmentmesonephrictubuledevelopmentmetanephricascendingthinlimbdevelopmentmetanephriccollectingductdevelopmentmetanephricdistaltubulemorphogenesismetanephricproximaltubuledevelopmentneuraltubedevelopmentpeptidyl-serinephosphorylationplacentabloodvesseldevelopmentpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofproteinbindingpositiveregulationoftranscriptionbyRNApolymeraseIIproteinexportfromnucleusproteinheterotetramerizationreceptorsignalingpathwayviaJAK-STATregulationofcelladhesionregulationofcellcycleregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticspindleorganizationregulationofproteasomalproteincatabolicprocessresponsetofluidshearstressskindevelopmentspinalcorddevelopment
26S proteasome non-ATPase regulatory subunit 8
3.7
61
75
F1LMQ3F1LMQ3F1LMQ3F1LMQ3proteasome-mediatedubiquitin-dependentproteincatabolicprocess
Dachshund homolog 1
4.1
67
87
DACH1DACH1Q9UI36Q9UI36developmentofprimaryfemalesexualcharacteristicsnegativeregulationofcellmigrationnegativeregulationofcellproliferationinvolvedincontactinhibitionnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationoffibroblastproliferationnegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofnuclearcellcycleDNAreplicationregulationoftranscriptionbyRNApolymeraseIIrespiratorygaseousexchangebyrespiratorysystemsucklingbehaviortypeBpancreaticcellproliferation
MH1 domain-containing protein
3.8
66
79
Q8CC31Q8CC31Q8CC31Q8CC31regulationofDNA-templatedtranscriptiontransforminggrowthfactorbetareceptorsignalingpathway
Deformed epidermal autoregulatory factor 1 homolog
3.7
49
90
DEAF1DEAF1O75398O75398anatomicalstructuremorphogenesisembryonicskeletalsystemdevelopmentgermcelldevelopmentnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIneuraltubeclosurepositiveregulationofDNA-templatedtranscriptionregulationofmammaryglandepithelialcellproliferationregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
Zinc finger CW-type PWWP domain protein 2
3.7
46
78
ZCPW2ZCPW2Q504Y3Q504Y3
MKIAA0668 protein
3.7
93
68
Q6A022Q6A022Q6A022Q6A022
Carbonic anhydrase-related protein
3.7
56
78
CAH8CAH8P35219P35219one-carbonmetabolicprocessphosphatidylinositol-mediatedsignaling
Gametocyte-specific factor 1
3.8
47
89
GTSF1GTSF1Q9DAN6Q9DAN6celldifferentiationspermatogenesis
Stromal membrane-associated protein 2
3.8
78
72
SMAP2SMAP2Q8WU79Q8WU79
Transducin-like enhancer protein 1
3.7
75
79
TLE1TLE1Q04724Q04724animalorganmorphogenesisnegativeregulationofanoikisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofDNA-templatedtranscriptionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofWntsignalingpathwaypositiveregulationofgeneexpressionsignaltransductionWntsignalingpathway
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
3.7
80
72
✔
SDHASDHAP31040P31040mitochondrialelectrontransportsuccinatetoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesisrespiratoryelectrontransportchainsuccinatemetabolicprocesstricarboxylicacidcycle
General transcription factor IIH subunit 3
3.3
57
87
TF2H3TF2H3Q13889Q13889DNArepairnucleotide-excisionrepairphosphorylationofRNApolymeraseIIC-terminaldomaintranscriptionbyRNApolymeraseII
E3 ubiquitin-protein ligase parkin
3.8
52
88
S4X0T1S4X0T1S4X0T1S4X0T1autophagy
Histone deacetylase complex subunit SAP30L
3.7
62
85
SP30LSP30LQ9HAJ7Q9HAJ7negativeregulationofcellmigrationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofstemcellpopulationmaintenanceregulationofDNA-templatedtranscription
Phosphotransferase
3.7
84
69
Q53Y25Q53Y25Q53Y25Q53Y25calciumionimportcellularglucosehomeostasisglucosemetabolicprocessglycolyticprocessNADPmetabolicprocesspositiveregulationofinsulinsecretionregulationofpotassiumiontransport
Baculoviral IAP repeat-containing 7
3.8
59
57
Q6R308Q6R308Q6R308Q6R308regulationofapoptoticprocessregulationofendopeptidaseactivity
Ubiquitin carboxyl-terminal hydrolase 13
3.8
60
85
UBP13UBP13Q92995Q92995autophagycellpopulationproliferationmaintenanceofunfoldedproteininvolvedinERADpathwaymelanocytedifferentiationpositiveregulationofERADpathwayproteindeubiquitinationproteinK29-linkeddeubiquitinationproteinK6-linkeddeubiquitinationproteinK63-linkeddeubiquitinationproteinstabilizationregulationofautophagyregulationofDNA-templatedtranscriptionubiquitin-dependentproteincatabolicprocess
Tyrosine-protein phosphatase non-receptor type 13
3.7
88
68
PTN13PTN13Q12923Q12923cellularresponsetotoxicsubstancenegativeregulationofexcitatorysynapseassemblynegativeregulationofproteinphosphorylationpeptidyl-tyrosinedephosphorylationproteindephosphorylationregulationofphosphatidylinositol3-kinasesignaling
Arf-GAP domain and FG repeat-containing protein 1
3.8
74
72
AGFG1AGFG1P52594P52594acrosomeassemblyintermediatefilamentorganizationmRNAexportfromnucleusspermatidnucleusdifferentiation
Histone acetyltransferase KAT2A
3.7
45
89
KAT2AKAT2AQ9JHD2Q9JHD2alpha-tubulinacetylationcellularresponsetonervegrowthfactorstimuluscellularresponsetotumornecrosisfactorchromatinremodelingfibroblastproliferationgluconeogenesisheartdevelopmenthistonedeubiquitinationhistoneH3acetylationhistoneH3-K14acetylationhistonesuccinylationinuteroembryonicdevelopmentinternalpeptidyl-lysineacetylationintracellulardistributionofmitochondrialimbdevelopmentlong-termmemorymetencephalondevelopmentmidbraindevelopmentmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2Adeubiquitinationmulticellularorganismgrowthnegativeregulationofcentriolereplicationnervoussystemdevelopmentneuraltubeclosurepeptidyl-lysineglutarylationpositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcellprojectionorganizationpositiveregulationofcytokineproductionpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgluconeogenesispositiveregulationofhistonemodificationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbonedevelopmentregulationofcartilagedevelopmentregulationofcellcycleregulationofcelldivisionregulationofDNArepairregulationofDNA-templatedtranscriptionregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationofproteinstabilityregulationofregulatoryTcelldifferentiationregulationofRNAsplicingregulationofstemcellpopulationmaintenanceregulationofsynapticplasticityregulationofTcellactivationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylationresponsetonutrientlevelsresponsetoorganiccycliccompoundsomitogenesistelencephalondevelopment
Vesicle-associated membrane protein 2
3.7
53
76
VAMP2STX1AP63045P32851calcium-ionregulatedexocytosiscellularresponsetoinsulinstimuluseosinophildegranulationestablishmentoflocalizationincellexocyticinsertionofneurotransmitterreceptortopostsynapticmembraneGolgitoplasmamembraneproteintransporthormonesecretionlong-termsynapticpotentiationmembranefusionpositiveregulationofintracellularproteintransportproteintransportprotein-containingcomplexassemblyregulatedexocytosisregulationofdelayedrectifierpotassiumchannelactivityregulationofexocytosisregulationofsynapticvesiclerecyclingregulationofvesicle-mediatedtransportresponsetoglucoseSNAREcomplexassemblysynapticvesicledockingsynapticvesicleendocytosissynapticvesicleexocytosisvesiclefusionvesicle-mediatedtransportexocytosisinsulinsecretionintracellularproteintransportmodulationofexcitatorypostsynapticpotentialneurotransmittertransportpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofexocytosispositiveregulationofneurotransmittersecretionpositiveregulationofnorepinephrinesecretionproteinlocalizationtomembraneproteinsumoylationregulationofsynapticvesicleprimingresponsetogravitysecretionbycellsynapticvesiclefusiontopresynapticactivezonemembranevesicledocking
LIM domain transcription factor LMO4
3.9
46
85
LMO4LMO4P61969P61969motorneuronaxonguidancenegativeregulationofprotein-containingcomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIIneuraltubeclosurepositiveregulationofkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellactivationregulationofcellfatespecificationregulationofcellmigrationregulationoftranscriptionbyRNApolymeraseIIspinalcordassociationneurondifferentiationspinalcordmotorneuroncellfatespecificationspinalcordmotorneurondifferentiationthymusdevelopmentventralspinalcordinterneurondifferentiationventricularseptumdevelopment
Cleavage and polyadenylation specificity factor subunit 4
4.0
42
88
CPSF4CPSF4O95639O95639pre-mRNAcleavagerequiredforpolyadenylation
TNF receptor-associated factor 2
4.1
47
90
TRAF2TRAF2Q12933Q12933activationofNF-kappaB-inducingkinaseactivitycellularresponsetonitricoxideinterleukin-17-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressmRNAstabilizationnegativeregulationofglialcellapoptoticprocessnegativeregulationofneurondeathpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinterleukin-2productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellcytokineproductionpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayprogrammednecroticcelldeathproteinautoubiquitinationproteincatabolicprocessproteinK63-linkedubiquitinationprotein-containingcomplexassemblyregulationofapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingregulationofimmunoglobulinproductionregulationofprotein-containingcomplexassemblyresponsetoendoplasmicreticulumstresssignaltransductionsignaltransductioninvolvedinregulationofgeneexpressiontumornecrosisfactor-mediatedsignalingpathway
E3 SUMO-protein ligase ZBED1
3.7
44
81
ZBED1ZBED1O96006O96006negativeregulationbyhostofviralgenomereplicationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinautosumoylationproteinsumoylationregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Substance-P receptor
2.1
66
85
NK1RNK1RP25103P25103acuteinflammatoryresponseaggressivebehaviorangiotensin-mediateddrinkingbehaviorassociativelearningbehavioralresponsetopaindetectionofabioticstimuluseatingbehaviorinflammatoryresponselong-termmemoryoperantconditioningphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofactionpotentialpositiveregulationofbloodpressurepositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofepithelialcellmigrationpositiveregulationofepithelialcellproliferationpositiveregulationofflagellatedspermmotilitypositiveregulationofhormonesecretionpositiveregulationofleukocytemigrationpositiveregulationoflymphocyteproliferationpositiveregulationofossificationpositiveregulationofrenalsodiumexcretionpositiveregulationofsalivasecretionpositiveregulationofstressfiberassemblypositiveregulationofsynaptictransmissioncholinergicpositiveregulationofsynaptictransmissionGABAergicpositiveregulationofuterinesmoothmusclecontractionpositiveregulationofvascularpermeabilitypositiveregulationofvasoconstrictionregulationofsmoothmusclecellmigrationregulationofsmoothmusclecellproliferationresponsetoauditorystimulusresponsetoelectricalstimulusresponsetoestradiolresponsetoethanolresponsetoheatresponsetomorphineresponsetonicotineresponsetoozoneresponsetoprogesteronesensoryperceptionofpainsmoothmusclecontractioninvolvedinmicturitionspermejaculationtachykininreceptorsignalingpathway
DEAH (Asp-Glu-Ala-His) box polypeptide 37
3.7
72
85
Q6NZL1Q6NZL1Q6NZL1Q6NZL1braindevelopmentmaturationofSSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)positiveregulationofmalegonaddevelopmentribosomeassemblyribosomebiogenesis
LIM and senescent cell antigen-like-containing domain protein 2
3.9
61
86
LIMS2LIMS2Q7Z4I7Q7Z4I7cell-celladhesioncell-celljunctionorganizationcholangiocyteproliferationintegrin-mediatedsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcholangiocyteproliferationnegativeregulationofhepatocyteproliferationnegativeregulationofneuralprecursorcellproliferationneuralprecursorcellproliferationpositiveregulationofintegrin-mediatedsignalingpathwaypositiveregulationofsubstrateadhesion-dependentcellspreading
Nitric oxide synthase, brain
4.0
68
82
NOS1NOS1P29475P29475argininecatabolicprocesscellredoxhomeostasiscellularresponsetogrowthfactorstimulusmulticellularorganismalresponsetostressmusclecontractionmyoblastfusionnegativeregulationofbloodpressurenegativeregulationofcalciumiontransportnegativeregulationofcalciumiontransportintocytosolnegativeregulationofhydrolaseactivitynegativeregulationofpotassiumiontransportnegativeregulationofserotoninuptakeneurotransmitterbiosyntheticprocessnitricoxidebiosyntheticprocessnitricoxidemediatedsignaltransductionpeptidyl-cysteineS-nitrosylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofguanylatecyclaseactivitypositiveregulationofhistoneacetylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsodiumiontransmembranetransportpositiveregulationoftheforceofheartcontractionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofcardiacmusclecontractionregulationofryanodine-sensitivecalcium-releasechannelactivityregulationofsodiumiontransportresponsetoheatresponsetohormoneresponsetohypoxiaresponsetolipopolysaccharideretrogradetrans-synapticsignalingbynitricoxidestriatedmusclecontractionvasodilationxenobioticcatabolicprocess
Lysine-specific demethylase 5C
4.0
70
88
KDM5CKDM5CP41229P41229chromatinremodelinghistonelysinedemethylationnegativeregulationofDNA-templatedtranscriptionrhythmicprocess
Protein transport protein Sec24C
3.8
71
90
SC24CSC24CP53992P53992COPII-coatedvesiclecargoloadingendoplasmicreticulumtoGolgivesicle-mediatedtransportinuteroembryonicdevelopmentintracellularproteintransport
Nuclear protein localization protein 4 homolog
3.7
49
92
NPL4NPL4Q9ES54Q9ES54GolgiorganizationnegativeregulationofRIG-IsignalingpathwaynegativeregulationoftypeIinterferonproductionretrogradeproteintransportERtocytosolubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocess
Transcriptional repressor protein YY1
3.8
37
91
TYY1TYY1P25490P25490anterior/posteriorpatternspecificationBcelldifferentiationcamera-typeeyemorphogenesiscellularresponsetoDNAdamagestimuluscellularresponsetointerleukin-1cellularresponsetoUVchromatinremodelingdouble-strandbreakrepairviahomologousrecombinationimmunoglobulinheavychainV-D-Jrecombinationnegativeregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentnegativeregulationofgeneexpressionnegativeregulationofinterferon-betaproductionnegativeregulationofmiRNAtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationoftelomeremaintenanceinresponsetoDNAdamagepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleregulationofchromosomeorganizationregulationofDNArepairregulationofDNAreplicationregulationofDNAstrandelongationregulationofembryonicdevelopmentregulationoftranscriptionbyRNApolymeraseIIresponsetoprostaglandinFresponsetoUV-CRNAlocalizationspermatogenesistelomeremaintenance
E3 ubiquitin-protein ligase SHPRH
3.8
44
86
SHPRHSHPRHQ149N8Q149N8cellularresponsetoDNAdamagestimulusDNArepairnucleosomeassemblyproteinpolyubiquitinationproteinubiquitination
E3 ubiquitin-protein ligase RAD18
3.8
42
85
✔
RAD18RAD18Q9NS91Q9NS91cellularresponsetoDNAdamagestimulusDNArepairnegativeregulationofcelldeathpositiveregulationofchromosomesegregationpostreplicationrepairproteinautoubiquitinationproteinmonoubiquitination
Zinc finger protein Gfi-1
3.8
36
90
GFI1GFI1Q07120Q07120cellfatecommitmentcellfatespecificationcellularresponsetolipopolysaccharideinnerearauditoryreceptorcelldifferentiationinnerearmorphogenesismechanosensorybehaviornegativeregulationofcalcidiol1-monooxygenaseactivitynegativeregulationofcellfatespecificationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofneuronprojectiondevelopmentnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellfatespecificationpositiveregulationofinterleukin-6-mediatedsignalingpathwayregulationoftoll-likereceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseII
B-cell lymphoma 6 protein
3.8
38
89
BCL6BCL6P41182P41182actincytoskeletonorganizationBcellproliferationcellmorphogenesiscell-matrixadhesioncellularresponsetoDNAdamagestimuluserythrocytedevelopmentgerminalcenterformationhistonedeacetylationinflammatoryresponseisotypeswitchingtoIgEisotypesnegativeregulationofBcellapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcell-matrixadhesionnegativeregulationofcellularsenescencenegativeregulationofDNA-templatedtranscriptionnegativeregulationofisotypeswitchingtoIgEisotypesnegativeregulationofleukocyteproliferationnegativeregulationofmastcellcytokineproductionnegativeregulationofmitoticcellcycleDNAreplicationnegativeregulationofNotchsignalingpathwaynegativeregulationofplasmacelldifferentiationnegativeregulationofRhoproteinsignaltransductionnegativeregulationofT-helper2celldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIplasmacelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationofBcellproliferationpositiveregulationofhistonedeacetylationpositiveregulationofneurondifferentiationpositiveregulationofregulatoryTcelldifferentiationproteinlocalizationpyramidalneurondifferentiationregulationofcelldifferentiationregulationofcellpopulationproliferationregulationofcytokineproductionregulationofgerminalcenterformationregulationofGTPaseactivityregulationofimmuneresponseregulationofimmunesystemprocessregulationofinflammatoryresponseregulationofmemoryTcelldifferentiationregulationofTcellproliferationregulationoftranscriptionbyRNApolymeraseIIRhoproteinsignaltransductionspermatogenesisT-helper2celldifferentiationtranscriptionbyRNApolymeraseIItype2immuneresponse
Optineurin
4.0
40
91
OPTNOPTNQ96CV9Q96CV9autophagycelldeathcellularresponsetounfoldedproteindefenseresponsetoGram-negativebacteriumGolgiorganizationGolgiribbonformationGolgitoplasmamembraneproteintransportinnateimmuneresponsenegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofreceptorrecyclingparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofautophagypositiveregulationofxenophagyproteinlocalizationtoGolgiapparatusregulationofI-kappaBkinase/NF-kappaBsignalingsignaltransduction
THAP domain-containing protein 11
3.8
59
77
THA11THA11Q96EK4Q96EK4cellpopulationproliferationelectrontransportchainnegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationpositiveregulationofandrogenreceptoractivityregulationofmitochondrialtranscriptionregulationoftranscriptionbyRNApolymeraseII
PR domain zinc finger protein 4
3.8
40
87
PRDM4PRDM4Q9UKN5Q9UKN5histoneH4-R3methylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressiontranscriptionbyRNApolymeraseII
Growth-regulated alpha protein
3.8
47
86
GROAGROAP09341P09341actincytoskeletonorganizationantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponseintracellularsignaltransductionkillingofcellsofanotherorganismnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentneutrophilchemotaxissignaltransduction
APOBEC3H
3.5
56
76
B7TQM6B7TQM6B7TQM6B7TQM6
AP-1 complex subunit gamma-1
3.8
68
78
AP1G1AP1G1P22892P22892basolateralproteinsecretionendosometomelanosometransportGolgitolysosometransportGolgitovacuoletransportintracellularproteintransportmelanosomeassemblyplateletdensegranuleorganizationpositiveregulationofnaturalkillercelldegranulationpositiveregulationofnaturalkillercellmediatedcytotoxicityvesicle-mediatedtransport
Acetyl-CoA acetyltransferase, mitochondrial
3.8
76
72
THILTHILP24752P24752acetyl-CoAbiosyntheticprocessacetyl-CoAcatabolicprocessadiposetissuedevelopmentbraindevelopmentcoenzymeAbiosyntheticprocesscoenzymeAmetabolicprocessfattyacidbeta-oxidationisoleucinecatabolicprocessketonebodycatabolicprocessketonebodymetabolicprocessliverdevelopmentmetanephricproximalconvolutedtubuledevelopmentpropionyl-CoAbiosyntheticprocessresponsetohormoneresponsetoorganiccycliccompoundresponsetostarvation
Glycerol-3-phosphate acyltransferase 1, mitochondrial
3.8
73
74
GPAT1GPAT1Q9HCL2Q9HCL2activatedTcellproliferationactivation-inducedcelldeathofTcellsacyl-CoAmetabolicprocessCDP-diacylglycerolbiosyntheticprocessdefenseresponsetovirusdiacylglycerolbiosyntheticprocessfattyacidhomeostasisfattyacidmetabolicprocessglycerol-3-phosphatemetabolicprocessnegativeregulationofactivation-inducedcelldeathofTcellsphosphatidicacidbiosyntheticprocessphosphatidylglycerolbiosyntheticprocessphospholipidbiosyntheticprocessphospholipidhomeostasispositiveregulationofactivatedTcellproliferationpositiveregulationofmulticellularorganismgrowthregulationofcytokineproductionresponsetoglucosetriglyceridebiosyntheticprocess
Baculoviral IAP repeat-containing protein 1
3.8
52
91
BIRC1BIRC1Q13075Q13075defenseresponsetobacteriumdetectionofbacteriumicosanoidbiosyntheticprocessinflammatoryresponseinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofneuronapoptoticprocessnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynervoussystemdevelopmentpatternrecognitionreceptorsignalingpathwaypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofJNKcascadepyroptosisregulationofapoptoticprocess
Mitochondrial ribosomal protein S18A
3.8
46
82
F1RRH6F1RRH6F1RRH6F1RRH6translation
Mitochondrial ribosomal protein L32
3.8
nan
92
I3LTC4I3LTC4I3LTC4I3LTC4translation
Protein unc-79 homolog
3.8
48
80
UNC79UNC79Q9P2D8Q9P2D8
Thioredoxin domain-containing protein 12
3.8
50
77
✔
TXD12TXD12O95881O95881negativeregulationofcelldeathnegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathway
40S ribosomal protein S12
3.8
79
73
G1SFR8G1SFR8G1SFR8G1SFR8translation
E3 ubiquitin-protein ligase RNF123
3.8
41
87
RN123RN123Q5XPI4Q5XPI4proteolysisinvolvedinproteincatabolicprocess
Zinc finger and SCAN domain-containing protein 16
3.8
39
85
ZSC16ZSC16Q9H4T2Q9H4T2regulationoftranscriptionbyRNApolymeraseII
Rho-associated protein kinase 2
3.9
45
86
ROCK2ROCK2Q62868Q62868actincytoskeletonorganizationactomyosinstructureorganizationbloodvesseldiametermaintenancecellularresponsetoacetylcholinecellularresponsetotestosteronestimuluscentrosomeduplicationchromosomecondensationcorticalactincytoskeletonorganizationdendritemorphogenesisembryonicmorphogenesisepithelialtomesenchymaltransitionextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsI-kappaBkinase/NF-kappaBsignalingmitoticcytokinesismRNAdestabilizationnegativeregulationofangiogenesisnegativeregulationofbicellulartightjunctionassemblynegativeregulationofgeneexpressionnegativeregulationofmyosin-light-chain-phosphataseactivitynegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofproteinlocalizationtolysosomeneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofamyloidprecursorproteincatabolicprocesspositiveregulationofamyloid-betaformationpositiveregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofcardiacmusclehypertrophypositiveregulationofcellmigrationpositiveregulationofcentrosomeduplicationpositiveregulationofconnectivetissuegrowthfactorproductionpositiveregulationofconnectivetissuereplacementpositiveregulationofendothelialcellmigrationpositiveregulationoffibroblastgrowthfactorproductionpositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofproteinlocalizationtoearlyendosomepositiveregulationofproteinphosphorylationpositiveregulationofstressfiberassemblypostsynapticactincytoskeletonorganizationproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofangiotensin-activatedsignalingpathwayregulationofcelljunctionassemblyregulationofcellularresponsetohypoxiaregulationofcircadianrhythmregulationofestablishmentofendothelialbarrierregulationofkeratinocytedifferentiationregulationofnervoussystemprocessregulationofproteinmetabolicprocessregulationofsynapsematurationresponsetoangiotensinresponsetoischemiaresponsetotransforminggrowthfactorbetaRhoproteinsignaltransductionrhythmicprocesssmoothmusclecontractionviralRNAgenomereplication
Histone-lysine N-methyltransferase Smyd1
4.1
53
86
SMYD1SMYD1Q6DFW7Q6DFW7chromatinremodelingheartdevelopmenthistonelysinemethylationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofmyoblastdifferentiationpositiveregulationofmyotubedifferentiationskeletalmusclecelldifferentiation
Histone acetyltransferase KAT5
3.8
59
90
KAT5KAT5Q92993Q92993apoptoticprocesscellularresponsetoDNAdamagestimuluscellularresponsetoestradiolstimuluscellularresponsetoglucosestarvationcellularresponsetoglucosestimuluscellularsenescenceDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorDNArepair-dependentchromatinremodelingdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationestablishmentofmitoticspindleorientationhistoneacetylationhistoneH2AacetylationhistoneH4acetylationinnateimmuneresponselipiddropletdisassemblynegativeregulationofDNA-templatedtranscriptionnegativeregulationofinterleukin-2productionnegativeregulationoftranscriptionbyRNApolymeraseIIneuraltubedevelopmentneurogenesisnucleotide-excisionrepairpeptidyl-lysineacetylationpositiveregulationofattachmentofmitoticspindlemicrotubulestokinetochorepositiveregulationofautophagypositiveregulationofcircadianrhythmpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofmitoticsisterchromatidsegregationpositiveregulationofmyoblastdifferentiationpositiveregulationofproteinacetylationpositiveregulationofregulatoryTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftriglyceridebiosyntheticprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofapoptoticprocessregulationofcellcycleregulationofdouble-strandbreakrepairregulationofhematopoieticstemcelldifferentiationresponsetoionizingradiationspermDNAcondensationspermatiddevelopment
Zinc finger and BTB domain-containing protein 21
4.0
49
86
ZBT21ZBT21Q9ULJ3Q9ULJ3negativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Insulinoma-associated protein 1
3.8
43
83
INSM1INSM1Q01101Q01101adrenalchromaffincelldifferentiationcellcyclecellmigrationcellpopulationproliferationnegativeregulationofcellpopulationproliferationnegativeregulationofproteinphosphorylationnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationnoradrenergicneurondevelopmentnorepinephrinebiosyntheticprocesspancreaticAcelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcellmigrationpositiveregulationofneuralprecursorcellproliferationregulationofcellcycleregulationofcellcycleprocessregulationofgeneexpressionregulationofprotein-containingcomplexassemblysympatheticgangliondevelopmenttransdifferentiationtypeBpancreaticcelldevelopmenttypeBpancreaticcelldifferentiation
THAP domain-containing protein 2
3.9
50
83
THAP2THAP2Q9H0W7Q9H0W7
RNA-splicing ligase RtcB homolog
3.8
105
65
RTCBRTCBQ9Y3I0Q9Y3I0inuteroembryonicdevelopmentplacentadevelopment"tRNAexonligationutilizing23cyclicphosphateof5-exonassourceoflinkagephosphate"tRNAsplicingviaendonucleolyticcleavageandligation
Methionine aminopeptidase 1
3.8
46
86
✔
MAP11MAP11Q8BP48Q8BP48proteininitiatormethionineremovalinvolvedinproteinmaturation
Protein bicaudal D homolog 2
3.8
50
78
✔
BICD2BICD2Q8TD16Q8TD16centrosomelocalizationmicrotubuleanchoringatmicrotubuleorganizingcentermicrotubule-basedmovementminus-end-directedorganelletransportalongmicrotubulemRNAtransportproteinlocalizationtoGolgiapparatusproteinlocalizationtoorganelleproteintransportregulationofmicrotubulecytoskeletonorganizationretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Ras GTPase-activating protein 1
3.8
67
75
RASA1RASA1P20936P20936bloodvesselmorphogenesisephrinreceptorsignalingpathwayintracellularsignaltransductionmitoticcytokinesisnegativeregulationofapoptoticprocessnegativeregulationofcelladhesionnegativeregulationofcell-matrixadhesionnegativeregulationofneuronapoptoticprocessregulationofactinfilamentpolymerizationregulationofcellshaperegulationofGTPaseactivityregulationofRNAmetabolicprocesssignaltransductionvasculogenesis
Sodium channel modifier 1
3.8
66
77
SCNM1SCNM1Q9BWG6Q9BWG6alternativemRNAsplicingviaspliceosomeRNAsplicing
Eukaryotic translation initiation factor 2 subunit 1
3.8
64
77
G1T2G4G1T2G4G1T2G4G1T2G4
Protein kinase C
3.8
45
80
Q4VA93Q4VA93Q4VA93Q4VA93desmosomeassemblynegativeregulationofglialcellapoptoticprocesspositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelladhesionpositiveregulationofendothelialcellproliferationpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofmitoticcellcyclepost-translationalproteinmodificationproteinphosphorylationregulationofplateletaggregationresponsetointerleukin-1
Probable ribonuclease ZC3H12C
4.0
37
89
ZC12CZC12CQ5DTV4Q5DTV4RNAphosphodiesterbondhydrolysisendonucleolytic
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
4.4
79
66
PREX1PREX1Q8TCU6Q8TCU6actinfilamentpolymerizationGprotein-coupledreceptorsignalingpathwayintracellularsignaltransductionneutrophilactivationneutrophilchemotaxispositiveregulationofGTPaseactivitypositiveregulationofsubstrateadhesion-dependentcellspreadingregulationofsmallGTPasemediatedsignaltransductionsuperoxidemetabolicprocessTcelldifferentiation
DNA-dependent metalloprotease SPRTN
3.8
50
85
SPRTNSPRTNQ9H040Q9H040cellularresponsetoDNAdamagestimuluspositiveregulationofproteinubiquitinationproteinautoprocessingprotein-DNAcovalentcross-linkingrepairproteolysisresponsetoUVtranslesionsynthesis
Cell growth-regulating nucleolar protein
3.9
51
89
LYARLYARQ08288Q08288erythrocytedevelopmentinnateimmuneresponsenegativeregulationofinnateimmuneresponsenegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofphagocytosispositiveregulationoftranscriptionbyRNApolymeraseIrRNAprocessing
FACT complex subunit SPT16
3.8
84
70
SP16HSP16HQ9Y5B9Q9Y5B9DNArepairDNAreplicationnucleosomeassemblynucleosomedisassemblypositiveregulationofDNA-templatedtranscriptionelongationtranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoter
E3 ubiquitin-protein ligase HUWE1
2.0
nan
86
✔
HUWE1UBBQ7Z6Z7P0CG47base-excisionrepaircelldifferentiationcircadianregulationofgeneexpressionGolgiorganizationhistoneubiquitinationmembranefusionnegativeregulationofmitochondrialfusionpositiveregulationofmitophagyinresponsetomitochondrialdepolarizationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofproteinubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Density-regulated protein
3.8
38
89
DENRDENRO43583O43583formationoftranslationpreinitiationcomplexIRES-dependentviraltranslationalinitiationribosomedisassemblytranslationreinitiation
PHD finger protein 6
3.9
52
86
✔
PHF6PHF6Q8IWS0Q8IWS0blastocysthatchingnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
3.8
89
68
ACDSBACDSBP45954P45954fattyacidmetabolicprocessisoleucinecatabolicprocess
Ceramide transfer protein
3.8
84
67
CERTCERTA8K7S2A8K7S2cellmorphogenesiscellpopulationproliferationceramidemetabolicprocessceramidetransportendoplasmicreticulumorganizationERtoGolgiceramidetransportheartmorphogenesisimmuneresponseinuteroembryonicdevelopmentintermembranelipidtransferintermembranesphingolipidtransferlipidhomeostasismitochondrionmorphogenesismusclecontractionresponsetoendoplasmicreticulumstresssignaltransduction
UNC79
3.8
41
85
E5CYJ9E5CYJ9E5CYJ9E5CYJ9
Prostaglandin reductase 3
3.8
69
77
PTGR3PTGR3Q8N4Q0Q8N4Q0negativeregulationoffatcelldifferentiation
Spermidine synthase
3.8
79
71
SPEESPEEP19623P19623cellularresponsetoleukemiainhibitoryfactorpolyaminebiosyntheticprocesspolyaminemetabolicprocessspermidinebiosyntheticprocess
Sterile alpha motif domain-containing protein 9
3.8
69
77
SAMD9SAMD9Q5K651Q5K651endosomalvesiclefusioninnateimmuneresponse
ATPase WRNIP1
2.0
37
88
WRIP1WRIP1Q96S55Q96S55DNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationinnateimmuneresponseregulationofDNA-templatedDNAreplicationinitiation
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
4.0
93
71
GPTGPTQ9H3H5Q9H3H5dolicholmetabolicprocessdolichol-linkedoligosaccharidebiosyntheticprocessproteinN-linkedglycosylationUDP-N-acetylglucosaminemetabolicprocess
Protein DDI1 homolog 2
3.8
58
78
DDI2DDI2Q5TDH0Q5TDH0cellularresponsetohydroxyureaproteasomalproteincatabolicprocessproteinprocessingregulationofDNAstabilityregulationofproteinstability
E3 ubiquitin-protein ligase SIAH2
3.8
49
79
SIAH2SIAH2O43255O43255amyloidfibrilformationapoptoticprocesscanonicalWntsignalingpathwaycellcyclenegativeregulationofapoptoticprocessnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofcircadianrhythmregulationofproteinubiquitinationrhythmicprocesssmallGTPasemediatedsignaltransductionubiquitin-dependentproteincatabolicprocess
Beta-defensin 104
2.0
52
88
D104AD104AQ8WTQ1Q8WTQ1cellularresponsetophorbol13-acetate12-myristatedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponsemonocytechemotaxispositivechemotaxis
E3 ubiquitin-protein ligase Midline-1
3.9
50
87
TRI18TRI18O15344O15344microtubulecytoskeletonorganizationnegativeregulationofmicrotubuledepolymerizationpatternspecificationprocesspositiveregulationofstress-activatedMAPKcascadeproteinlocalizationtomicrotubuleregulationofmicrotubulecytoskeletonorganization
Inhibitor of growth protein 5
3.7
44
91
ING5ING5Q8WYH8Q8WYH8apoptoticsignalingpathwayDNAreplication-dependentchromatindisassemblyfibroblastproliferationhistoneH4-K12acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationhistonemodificationnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastproliferationnegativeregulationofgrowthpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofDNA-templatedtranscriptionproteinacetylationregulationofcellcycleregulationofcellgrowthregulationofdevelopmentalprocessregulationofDNAbiosyntheticprocessregulationofDNAreplicationregulationofDNA-templatedtranscriptionregulationofhemopoiesis
ATP-sensitive inward rectifier potassium channel 11
3.8
55
77
B2RC52B2RC52B2RC52B2RC52negativeregulationofinsulinsecretionpotassiumionimportacrossplasmamembraneregulationofiontransmembranetransport
Potassium-transporting ATPase alpha chain 2
4.2
70
78
AT12AAT12AP54708P54708cellularpotassiumionhomeostasiscellularsodiumionhomeostasispotassiumionhomeostasispotassiumionimportacrossplasmamembraneprotontransmembranetransportregulationofpHresponsetometalionresponsetoorganiccycliccompoundsodiumionexportacrossplasmamembrane
Beta-adrenergic receptor kinase 1
3.8
42
82
ARBK1ARBK1P21146P21146cardiacmusclecontractiondesensitizationofGprotein-coupledreceptorsignalingpathwayGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwayheartdevelopmentintracellularproteintransportnegativeregulationofrelaxationofsmoothmusclenegativeregulationofstriatedmusclecontractionnegativeregulationoftheforceofheartcontractionbychemicalsignalpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofproteinlocalizationtociliumpositiveregulationofsmoothenedsignalingpathwayproteinphosphorylationregulationofsignaltransductionregulationoftheforceofheartcontractiontachykininreceptorsignalingpathwayviralentryintohostcellviralgenomereplication
Rapamycin-insensitive companion of mTOR
3.8
66
69
RICTRRICTRQ6R327Q6R327actincytoskeletonreorganizationcellularresponsetonutrientlevelscytoskeletonorganizationembryodevelopmentendinginbirthoregghatchingnegativeregulationofapoptoticprocesspeptidyl-serinephosphorylationphosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellgrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofTORsignalingregulationofactincytoskeletonorganizationregulationofestablishmentofcellpolarityregulationofgeneexpressionregulationofGTPaseactivityregulationofinflammatoryresponseregulationofpeptidyl-serinephosphorylationregulationofproteinkinaseBsignalingTORC2signaling
Ubiquitin-conjugating enzyme E2 S
2.0
nan
88
UBE2SUBBQ16763P0CG47anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionexitfrommitosisfreeubiquitinchainpolymerizationpositiveregulationofubiquitinproteinligaseactivityproteinK11-linkedubiquitinationproteinK27-linkedubiquitinationproteinK29-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationubiquitin-dependentproteincatabolicprocessenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Ribonuclease SLFN12
2.0
50
86
SLN12SLN12Q8IYM2Q8IYM2apoptoticsignalingpathwayrRNAcatabolicprocess
E3 ubiquitin-protein ligase ZFP91
3.8
53
84
ZFP91ZFP91Q96JP5Q96JP5activationofNF-kappaB-inducingkinaseactivityproteinK63-linkedubiquitinationregulationoftranscriptionbyRNApolymeraseII
Integrator complex subunit 13
3.8
81
75
✔
INT13INT13Q9NVM9Q9NVM9celldivisioncentrosomelocalizationflagellatedspermmotilitymitoticspindleorganizationproteinlocalizationtonuclearenveloperegulationoffertilizationregulationofmitoticcellcycleregulationoftranscriptionelongationbyRNApolymeraseIIsnRNAprocessing
116 kDa U5 small nuclear ribonucleoprotein component
4.5
72
68
✔
U5S1U5S1Q15029Q15029cellularresponsetoxenobioticstimulusmRNAsplicingviaspliceosomeresponsetococaine
Fanconi anemia core complex-associated protein 20
3.8
43
84
FAP20FAP20Q6NZ36Q6NZ36cellularresponsetoDNAdamagestimulusinterstrandcross-linkrepairproteinmonoubiquitinationtranslesionsynthesis
DDB1- and CUL4-associated factor 15
3.9
60
89
DCA15DCA15Q66K64Q66K64immunesystemprocessproteinpolyubiquitinationproteinubiquitinationregulationofnaturalkillercellactivation
Mothers against decapentaplegic homolog 9
4.0
65
87
SMAD9SMAD9O15198O15198anatomicalstructuremorphogenesisBMPsignalingpathwaycelldifferentiationcellularresponsetoBMPstimuluspositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimulusSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Amyloid beta (A4) protein-binding, family B, member 1 interacting protein
4.6
48
77
B1AYC9B1AYC9B1AYC9B1AYC9signaltransduction
Coatomer subunit alpha
3.8
77
81
✔
COPACOPAP53621P53621endoplasmicreticulumtoGolgivesicle-mediatedtransportintra-Golgivesicle-mediatedtransportintracellularproteintransportpancreaticjuicesecretionretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Ubiquitin carboxyl-terminal hydrolase 2
3.8
48
87
UBP2UBP2O75604O75604cellcyclecircadianbehaviorcircadianregulationofgeneexpressionentrainmentofcircadianclockbyphotoperiodlocomotorrhythmmuscleorgandevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofmitoticcellcycleproteindeubiquitinationproteinstabilizationregulationofsignaltransductionbyp53classmediatorubiquitin-dependentproteincatabolicprocess
Uridine diphosphate glucose pyrophosphatase NUDT14
3.8
84
69
NUD14NUD14O95848O95848nucleosidephosphatemetabolicprocessproteinN-linkedglycosylationviaasparagineribosephosphatemetabolicprocess
Betaine--homocysteine S-methyltransferase 1
3.8
85
60
BHMT1BHMT1Q93088Q93088"denovoL-methioninebiosyntheticprocess"amino-acidbetainecatabolicprocessamino-acidbetainemetabolicprocessL-methioninesalvagemethioninebiosyntheticprocessproteinmethylationregulationofhomocysteinemetabolicprocess
Damage-control phosphatase ARMT1
3.8
79
70
ARMT1ARMT1Q9H993Q9H993cellularresponsetoDNAdamagestimulusmethylationregulationofresponsetoDNAdamagestimulus
Zinc finger CCCH-type with G patch domain-containing protein
3.8
46
80
ZGPATZGPATQ8N5A5Q8N5A5negativeregulationofDNA-templatedtranscriptionnegativeregulationofepidermalgrowthfactor-activatedreceptoractivitynegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Probable ubiquitin carboxyl-terminal hydrolase FAF-X
4.0
51
76
✔
USP9XUSP9XQ93008Q93008amyloidfibrilformationaxonextensionBMPsignalingpathwaycelldivisioncellmigrationchromosomesegregationfemalegametegenerationmonoubiquitinatedproteindeubiquitinationnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuronmigrationpositiveregulationofDNAdemethylationpositiveregulationofproteinbindingpositiveregulationofTORC2signalingproteindeubiquitinationproteindeubiquitinationinvolvedinubiquitin-dependentproteincatabolicprocessproteinimportintoperoxisomematrixreceptorrecyclingproteinK63-linkeddeubiquitinationproteinlocalizationproteinstabilizationproteinubiquitinationregulationofcircadianrhythmrhythmicprocesstransforminggrowthfactorbetareceptorsignalingpathway
Protein kinase C delta type
3.8
45
87
A0A140UHX0A0A140UHX0A0A140UHX0A0A140UHX0apoptoticprocesscellcycleproteinphosphorylation
Zinc finger protein 292
3.8
39
89
ZN292ZN292O60281O60281regulationoftranscriptionbyRNApolymeraseII
Transient receptor potential cation channel subfamily M member 7
3.8
66
90
TRPM7TRPM7Q923J1Q923J1actomyosinstructureorganizationcalciumiontransportcalcium-dependentcell-matrixadhesioncationtransmembranetransportcellularmagnesiumionhomeostasisdivalentinorganiccationhomeostasismemorynecroptoticprocesspositiveregulationofapoptoticprocessproteinautophosphorylationproteinphosphorylationproteintetramerization
Insulin-degrading enzyme
3.8
81
69
IDEIDEP14735P14735amyloid-betaclearanceamyloid-betaclearancebycellularcatabolicprocessamyloid-betametabolicprocessantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbradykinincatabolicprocessdeterminationofadultlifespanhormonecatabolicprocessinsulincatabolicprocessinsulinmetabolicprocessinsulinreceptorsignalingpathwaypeptidecatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofaerobicrespirationubiquitinrecycling
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
3.8
106
66
SUCB2SUCB2Q96I99Q96I99succinyl-CoAcatabolicprocesssuccinyl-CoAmetabolicprocesstricarboxylicacidcycle
Methionine synthase reductase
3.8
67
71
MTRRMTRRQ9UBK8Q9UBK8DNAmethylationfolicacidmetabolicprocesshomocysteinecatabolicprocesshomocysteinemetabolicprocessmethioninebiosyntheticprocessnegativeregulationofcystathioninebeta-synthaseactivityS-adenosylmethioninecycle
Guanine nucleotide-binding protein subunit beta-5
3.8
95
68
GNB5GNB5P62881P62881darkadaptationdopaminereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaylightadaptionnegativeregulationofvoltage-gatedcalciumchannelactivitypositiveregulationofGTPaseactivity
Transcriptional regulator Kaiso
3.8
38
86
KAISOKAISOQ86T24Q86T24intracellularsignaltransductionnegativeregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIWntsignalingpathway
Lanosterol 14-alpha demethylase
3.8
74
69
CP51ACP51AQ16850Q16850cholesterolbiosyntheticprocessnegativeregulationofamyloid-betaclearancenegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionsteroidbiosyntheticprocesssterolmetabolicprocess
Histone deacetylase 7
4.0
41
85
HDAC7HDAC7Q8WUI4Q8WUI4cell-celljunctionassemblychromatinorganizationhistonedeacetylationnegativeregulationofinterleukin-2productionnegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofosteoblastdifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellmigrationinvolvedinsproutingangiogenesisproteindeacetylationproteinsumoylationvasculogenesis
SH2 domain-containing protein 1B
3.8
82
75
SH21BSH21BO14796O14796adaptiveimmuneresponseinnateimmuneresponseleukocyteactivationinvolvedinimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofnaturalkillercellmediatedimmunitypositiveregulationofpeptidyl-tyrosinephosphorylationregulationofimmuneresponseregulationofsignaltransduction
N-acetylgalactosamine kinase
3.8
86
70
GALK2GALK2Q01415Q01415carbohydratemetabolicprocessgalactosemetabolicprocess
Poly [ADP-ribose] polymerase
4.0
53
84
E7EQ52E7EQ52E7EQ52E7EQ52
Cystic fibrosis transmembrane conductance regulator
3.8
76
70
CFTRCFTRP13569P13569amelogenesisbicarbonatetransportcellularresponsetocAMPcellularresponsetoforskolinchloridetransmembranetransportcholesterolbiosyntheticprocesscholesteroltransportestablishmentoflocalizationincellintracellularpHelevationmembranehyperpolarizationmulticellularorganismalwaterhomeostasispositiveregulationofcyclicnucleotide-gatedionchannelactivitypositiveregulationofenamelmineralizationpositiveregulationofexocytosispositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofvoltage-gatedchloridechannelactivityresponsetoendoplasmicreticulumstressspermcapacitationtransepithelialwatertransporttransmembranetransportvesicledockinginvolvedinexocytosis
Zinc finger and BTB domain-containing protein 38
3.8
37
88
ZBT38ZBT38Q8NAP3Q8NAP3cellularresponsetoDNAdamagestimulusnegativeregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNAreplicationregulationofDNA-templatedtranscription
Zinc finger protein 40
3.8
33
87
ZEP1ZEP1P15822P15822BMPsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Protein kinase C delta type
3.9
51
89
KPCDKPCDP28867P28867activationofproteinkinaseactivityapoptoticprocessBcellproliferationcellchemotaxiscellcyclecellularresponsetoangiotensincellularresponsetohydrogenperoxidecellularresponsetohydroperoxidecellularresponsetooxidativestresscellularresponsetoUVcellularsenescencecollagenmetabolicprocessD-aspartateimportacrossplasmamembranedefenseresponsetobacteriumimmunoglobulinmediatedimmuneresponseintracellularsignaltransductionnegativeregulationofactinfilamentpolymerizationnegativeregulationoffilopodiumassemblynegativeregulationofglialcellapoptoticprocessnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofpeptidyl-tyrosinephosphorylationnegativeregulationofplateletaggregationneutrophilactivationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofapoptoticsignalingpathwaypositiveregulationofceramidebiosyntheticprocesspositiveregulationofendodeoxyribonucleaseactivitypositiveregulationofglucoseimportpositiveregulationofglucosylceramidecatabolicprocesspositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofphospholipidscramblaseactivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinimportintonucleuspositiveregulationofresponsetoDNAdamagestimuluspositiveregulationofsphingomyelincatabolicprocesspositiveregulationofsuperoxideaniongenerationpost-translationalproteinmodificationproteinautophosphorylationproteinphosphorylationregulationofactincytoskeletonorganizationregulationofceramidebiosyntheticprocessregulationofphosphorylationresponsetooxidativestressterminationofsignaltransduction
RCC1-like G exchanging factor-like protein
3.8
104
71
RCC1LRCC1LQ96I51Q96I51mitochondrialfusionpositiveregulationofmitochondrialtranslation
Fanconi anemia group I protein homolog
3.8
74
81
FANCIFANCIQ8K368Q8K368cellcycleDNArepairpositiveregulationofproteinubiquitination
Methionine-R-sulfoxide reductase B3
2.0
45
88
MSRB3MSRB3Q8IXL7Q8IXL7proteinrepairresponsetooxidativestress
Protein transport protein Sec31A
3.8
89
68
SC31ASC31AO94979O94979COPII-coatedvesiclecargoloadingendoplasmicreticulumorganizationendoplasmicreticulumtoGolgivesicle-mediatedtransportintracellularproteintransportresponsetocalciumion
BRCA2 and CDKN1A-interacting protein
3.8
56
83
BCCIPBCCIPQ9P287Q9P287DNArepairestablishmentofmitoticspindleorientationmicrotubuleanchoringmicrotubulecytoskeletonorganizationmitoticspindleassemblymitoticspindleorganizationneuroendocrinecelldifferentiationregulationofcyclin-dependentproteinserine/threoninekinaseactivity
Rho guanine nucleotide exchange factor 25
3.8
87
66
ARHGPARHGPQ86VW2Q86VW2axonguidanceregulationofsmallGTPasemediatedsignaltransduction
Zinc finger protein 423
3.8
35
89
ZN423ZN423Q2M1K9Q2M1K9celldifferentiationnegativeregulationofcold-inducedthermogenesisnegativeregulationofDNA-templatedtranscriptionnervoussystemdevelopmentNotchsignalingpathwaypositiveregulationofBMPsignalingpathwaypositiveregulationofDNA-templatedtranscriptionproteinlocalizationtociliumregulationofDNA-templatedtranscription
Calmodulin-binding transcription activator 1
3.8
83
69
CMTA1CMTA1Q5VUE1Q5VUE1neuromuscularprocesscontrollingbalancepositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofproteindephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Cleavage stimulation factor subunit 1
3.8
87
73
CSTF1CSTF1Q05048Q05048"mRNA3-endprocessing"
Endoribonuclease LACTB2
3.8
75
70
LACB2LACB2Q53H82Q53H82RNAphosphodiesterbondhydrolysisendonucleolytic
Cystic fibrosis transmembrane conductance regulator
3.8
76
69
Q20BJ8Q20BJ8Q20BJ8Q20BJ8
T-cell immunoreceptor with Ig and ITIM domains
3.8
69
75
TIGITTIGITQ495A1Q495A1negativeregulationofinterleukin-12productionnegativeregulationofTcellactivationpositiveregulationofinterleukin-10production
ADP-ribosylation factor-binding protein GGA3
4.3
77
74
GGA3GGA3Q9NZ52Q9NZ52endocyticrecyclingGolgitoplasmamembraneproteintransportGolgitoplasmamembranetransportintracellularproteintransportnegativeregulationofamyloid-betaformationpositiveregulationofproteincatabolicprocessproteincatabolicprocessproteindestabilizationproteinlocalizationtocellsurfaceproteintargetingtolysosomeregulationofproteinstability
Gamma-crystallin D
3.8
72
75
CRGDCRGDP07320P07320cellularresponsetoreactiveoxygenspecieslensdevelopmentincamera-typeeyelensfibercelldifferentiationvisualperception
ERI1 exoribonuclease 2
3.8
67
75
ERI2ERI2A8K979A8K979"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"
Choline/ethanolamine kinase
3.8
78
72
CHKBCHKBQ9Y259Q9Y259CDP-cholinepathwaymuscleorgandevelopmentphosphatidylcholinebiosyntheticprocessphosphatidylethanolaminebiosyntheticprocessphosphorylation
Nucleoside diphosphate kinase B
3.8
62
73
NDKBNDKBP22392P22392celladhesionCTPbiosyntheticprocessGTPbiosyntheticprocessintegrin-mediatedsignalingpathwaynegativeregulationofapoptoticprocessnucleosidediphosphatephosphorylationnucleosidetriphosphatebiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationpositiveregulationofkeratinocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofapoptoticprocessregulationofepidermisdevelopmentUTPbiosyntheticprocess
Protein fem-1 homolog B
5.1
62
81
FEM1BFNIP1Q9Z2G0Q68FD7apoptoticprocessbranchinginvolvedinprostateglandmorphogenesisepithelialcellmaturationepithelialcellmaturationinvolvedinprostateglanddevelopmentproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofDNAdamagecheckpointregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsregulationofubiquitin-proteintransferaseactivityubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathwayBcellapoptoticprocessBcelldifferentiationcellularresponsetostarvationimmatureBcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofBcellapoptoticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofTORsignalingregulationofpro-BcelldifferentiationregulationofproteinphosphorylationTORsignaling
Protein arginine N-methyltransferase 8
3.8
78
63
ANM8ANM8Q9NR22Q9NR22histonemethylationpeptidyl-argininemethylationpeptidyl-argininemethylationtoasymmetrical-dimethylarginineproteinhomooligomerizationproteinmethylationregulationofproteinbinding
Myelin transcription factor 1-like protein
3.8
70
82
MYT1LMYT1LP70475P70475negativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneurondevelopmentneurondifferentiationneuronfatecommitmentneuronfatespecificationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIsequesteringofmetalion
Telomerase reverse transcriptase
4.8
51
73
TERTTERTO14746O14746cellularresponsetohypoxiaDNAbiosyntheticprocessDNAstrandelongationestablishmentofproteinlocalizationtotelomeremitochondrionorganizationnegativeregulationofcellularsenescencenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofgeneexpressionnegativeregulationofmiRNAmaturationnegativeregulationofneuronapoptoticprocesspositiveregulationofangiogenesispositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofglucoseimportpositiveregulationofhaircyclepositiveregulationofmiRNAtranscriptionpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofproteinbindingpositiveregulationofproteinlocalizationtonucleoluspositiveregulationofstemcellproliferationpositiveregulationoftransdifferentiationpositiveregulationofvascularassociatedsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofWntsignalingpathwayregulationofproteinstabilityreplicativesenescenceresponsetocadmiumionRNA-templatedDNAbiosyntheticprocessRNA-templatedtranscriptionsiRNAprocessingsiRNAtranscriptiontelomeremaintenancetelomeremaintenanceviatelomerase
Glucocorticoid modulatory element-binding protein 1
3.7
nan
93
GMEB1GMEB1Q9Y692Q9Y692regulationoftranscriptionbyRNApolymeraseII
Isoform 2 of DENN domain-containing protein 1B
4.2
96
80
DEN1BDEN1BQ6P3S1-2Q6P3S1-2
Adiponectin receptor protein 1
3.9
77
72
PAQR1PAQR1Q96A54Q96A54adiponectin-activatedsignalingpathwayfattyacidoxidationglucosehomeostasishormone-mediatedsignalingpathwayleptin-mediatedsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofepithelialcellmigrationnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofcold-inducedthermogenesispositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofreceptorsignalingpathwayviaJAK-STATregulationofglucosemetabolicprocessregulationoflipidmetabolicprocess
26S proteasome non-ATPase regulatory subunit 2
3.9
59
74
✔
PSMD2PSMD2Q13200Q13200proteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofproteincatabolicprocess
DENN domain-containing protein 1A
4.1
91
82
DEN1ADEN1AQ8TEH3Q8TEH3endocyticrecyclingendocytosisproteintransportregulationofRabproteinsignaltransduction
E3 SUMO-protein ligase PIAS2
3.9
61
77
✔
PIAS2PIAS2O75928O75928negativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofDNA-bindingtranscriptionfactoractivityproteinsumoylationregulationoftranscriptionbyRNApolymeraseII
Potassium voltage-gated channel subfamily H member 2
3.9
62
77
KCNH2KCNH2Q12809Q12809cardiacmusclecontractioncellularresponsetoxenobioticstimulusmembranedepolarizationduringactionpotentialmembranerepolarizationmembranerepolarizationduringactionpotentialmembranerepolarizationduringcardiacmusclecellactionpotentialmembranerepolarizationduringventricularcardiacmusclecellactionpotentialnegativeregulationofpotassiumionexportacrossplasmamembranenegativeregulationofpotassiumiontransmembranetransportpositiveregulationofDNA-templatedtranscriptionpositiveregulationofpotassiumiontransmembranetransportpotassiumionexportacrossplasmamembranepotassiumionhomeostasispotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportregulationofheartratebycardiacconductionregulationofheartratebyhormoneregulationofmembranepotentialregulationofmembranerepolarizationregulationofpotassiumiontransmembranetransportregulationofventricularcardiacmusclecellmembranerepolarizationventricularcardiacmusclecellactionpotential
Cell cycle control protein 50A
4.1
63
77
CC50ACC50AQ9NV96Q9NV96aminophospholipidtransportphospholipidtranslocationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofphospholipidtranslocationpositiveregulationofproteinexitfromendoplasmicreticulumproteinlocalizationtoendosomexenobiotictransmembranetransport
Tyrosine-protein kinase Lck
3.8
35
90
CD4LCKP01730P06239adaptiveimmuneresponsecalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimulusdefenseresponsetoGram-negativebacteriumenzyme-linkedreceptorproteinsignalingpathwayhelperTcellenhancementofadaptiveimmuneresponseimmuneresponseinterleukin-15-mediatedsignalingpathwaymacrophagedifferentiationmaintenanceofproteinlocationincellpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmonocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofTcellactivationpositiveregulationofviralentryintohostcellregulationofcalciumiontransportregulationofTcellactivationsignaltransductionTcellactivationTcelldifferentiationTcellselectiontransmembranereceptorproteintyrosinekinasesignalingpathwayactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessBcellreceptorsignalingpathwaycelldifferentiationcellularzincionhomeostasisFc-gammareceptorsignalingpathwayhemopoiesisinnateimmuneresponseintracellularsignaltransductionleukocytemigrationpeptidyl-tyrosineautophosphorylationplateletactivationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofleukocytecell-celladhesionpositiveregulationofTcellreceptorsignalingpathwayproteinphosphorylationregulationoflymphocyteactivationreleaseofsequesteredcalciumionintocytosolresponsetoxenobioticstimulusTcellcostimulationTcellreceptorsignalingpathway
Bcl-2-related protein A1
2.1
51
81
B2LA1B2LA1Q16548Q16548extrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofapoptoticprocess
Histone deacetylase 6
3.8
49
82
HDAC6HDAC6Q9UBN7Q9UBN7aggresomeassemblyautophagyaxonaltransportofmitochondrioncellularresponsetohydrogenperoxidecellularresponsetomisfoldedproteincellularresponsetoparathyroidhormonestimuluscellularresponsetotopologicallyincorrectproteinciliumassemblyciliumdisassemblycollateralsproutingdendriticspinemorphogenesisepigeneticregulationofgeneexpressionhistonedeacetylationHsp90deacetylationintracellularproteintransportlysosomelocalizationnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofDNA-templatedtranscriptionnegativeregulationofhydrogenperoxidemetabolicprocessnegativeregulationofmicrotubuledepolymerizationnegativeregulationofoxidoreductaseactivitynegativeregulationofproteinacetylationnegativeregulationofprotein-containingcomplexassemblynegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofproteolysisnegativeregulationoftranscriptionbyRNApolymeraseIIparkin-mediatedstimulationofmitophagyinresponsetomitochondrialdepolarizationpeptidyl-lysinedeacetylationpolyubiquitinatedmisfoldedproteintransportpositiveregulationofcholangiocyteproliferationpositiveregulationofdendritemorphogenesispositiveregulationofepithelialcellmigrationpositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofsignalingreceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpositiveregulationoftubulindeacetylationproteindeacetylationproteindestabilizationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsprotein-containingcomplexdisassemblyregulationofandrogenreceptorsignalingpathwayregulationofautophagyregulationofautophagyofmitochondrionregulationofestablishmentofproteinlocalizationregulationoffatcelldifferentiationregulationofmacroautophagyregulationofmicrotubule-basedmovementregulationofproteinstabilityresponsetoamphetamineresponsetocorticosteroneresponsetodexamethasoneresponsetogrowthfactorresponsetoimmobilizationstressresponsetomisfoldedproteintubulindeacetylationubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Phosphatidylinositol 4-kinase beta
3.9
67
75
PI4KBPI4KBQ9UBF8Q9UBF8lysosomeorganizationphosphatidylinositolbiosyntheticprocessphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationreceptor-mediatedendocytosissignaltransduction
LanC-like protein 2
3.9
88
71
LANC2LANC2Q9NS86Q9NS86carbohydratemetabolicprocessnegativeregulationofDNA-templatedtranscriptionpeptidemodificationpositiveregulationofabscisicacid-activatedsignalingpathway
Choline kinase alpha
3.9
88
69
CHKACHKAP35790P35790CDP-cholinepathwaycellularresponsetoglucosestarvationlipiddropletdisassemblylipidmetabolicprocesslipidtransportphosphatidylcholinebiosyntheticprocessphosphatidylethanolaminebiosyntheticprocess
Cytosolic iron-sulfur assembly component 2A
4.2
71
75
CIA2ACIA2AQ9H5X1Q9H5X1chromosomesegregationiron-sulfurclusterassemblyproteinmaturationby4Fe-4Sclustertransferproteinmaturationbyiron-sulfurclustertransfer
B-cell lymphoma/leukemia 11A
3.8
56
94
BC11ABC11AQ9H165Q9H165cellularresponsetoL-glutamatenegativeregulationofaxonextensionnegativeregulationofbranchingmorphogenesisofanervenegativeregulationofcollateralsproutingnegativeregulationofdendritedevelopmentnegativeregulationofdendriteextensionnegativeregulationofneuronprojectiondevelopmentnegativeregulationofneuronremodelingnegativeregulationofproteinhomooligomerizationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcollateralsproutingpositiveregulationofgeneexpressionpositiveregulationofneuronprojectiondevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIproteinsumoylationregulationofdendritedevelopmentregulationoftranscriptionbyRNApolymeraseII
Gem-associated protein 5
5.0
nan
75
✔
GEMI5GEMI5Q8TEQ6Q8TEQ6mRNAsplicingviaspliceosomeprotein-containingcomplexassemblyregulationoftranslationspliceosomalsnRNPassemblytranslation
Cohesin subunit SA-1
3.9
83
69
STAG1STAG1Q8WVM7Q8WVM7celldivisionestablishmentofmitoticsisterchromatidcohesionlocalizationmitoticspindleassemblysisterchromatidcohesion
Carnitine O-palmitoyltransferase 2, mitochondrial
4.5
63
69
CPT2CPT2P18886P18886carnitinemetabolicprocessfattyacidbeta-oxidationinuteroembryonicdevelopmentlong-chainfattyacidmetabolicprocesslong-chainfattyacidtransportpositiveregulationofcold-inducedthermogenesisresponsetofattyacid
Baculoviral IAP repeat-containing protein 8
4.1
84
76
BIRC8BIRC8Q96P09Q96P09negativeregulationofapoptoticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofproteinubiquitinationregulationofcellcycle
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
3.9
61
74
ODBBODBBP21953P21953branched-chainaminoacidcatabolicprocesslipidmetabolicprocessresponsetocAMPresponsetoglucocorticoidresponsetonutrient
cDNA FLJ56846, highly similar to Zinc finger protein HRX
3.9
48
89
B4DIJ7B4DIJ7B4DIJ7B4DIJ7chromatinorganizationmethylation
ADP-ribosylhydrolase ARH3
3.9
86
68
ADPRSADPRSQ9NX46Q9NX46base-excisionrepairgap-fillingcellularresponsetosuperoxideDNArepairnegativeregulationofnecroptoticprocesspeptidyl-serineADP-deribosylation
Mitochondrial ribonuclease P catalytic subunit
3.9
59
82
✔
MRPP3MRPP3O15091O15091"mitochondrialtRNA5-endprocessing""tRNA5-leaderremoval"
Sal-like protein 4
3.8
37
90
SALL4SALL4Q8BX22Q8BX22embryoniclimbmorphogenesisheartdevelopmentinuteroembryonicdevelopmentinnercellmasscellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIneuraltubeclosureneuraltubedevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIsomaticstemcellpopulationmaintenancetissuedevelopmentventricularseptumdevelopment
Ras-associated and pleckstrin homology domains-containing protein 1
3.9
88
72
RAPH1RAPH1Q70E73Q70E73axonextensionsignaltransduction
Son of sevenless homolog 1
3.9
47
78
SOS1SOS1Q07889Q07889axonguidanceBcellhomeostasisBcellreceptorsignalingpathwaybloodvesselmorphogenesiscardiacatriummorphogenesiscytokine-mediatedsignalingpathwayepidermalgrowthfactorreceptorsignalingpathwayeyeliddevelopmentincamera-typeeyeFc-epsilonreceptorsignalingpathwayfibroblastgrowthfactorreceptorsignalingpathwayhairfollicledevelopmenthearttrabeculamorphogenesisinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwayleukocytemigrationmidbrainmorphogenesismulticellularorganismgrowthneurotrophinTRKreceptorsignalingpathwaypericardiummorphogenesispositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofGTPaseactivitypositiveregulationofsmallGTPasemediatedsignaltransductionRasproteinsignaltransductionregulationofcellpopulationproliferationregulationofMAPkinaseactivityregulationofpro-BcelldifferentiationregulationofTcelldifferentiationinthymusregulationofTcellproliferationregulationoftranscriptionbyRNApolymeraseIIroofofmouthdevelopmentsignaltransductionvitellogenesis
phosphatidylinositol-4,5-bisphosphate 3-kinase
3.9
86
66
Q3UDT3Q3UDT3Q3UDT3Q3UDT3phosphatidylinositol3-kinasesignalingphosphorylation
Threonine aspartase 1
4.1
nan
78
TASP1TASP1Q9H6P5Q9H6P5positiveregulationofDNA-templatedtranscriptionproteinmaturationproteolysis
Protein fem-1 homolog C
3.9
88
65
FEM1CFEM1CQ96JP0Q96JP0proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathway
Glutamine-dependent NAD(+) synthetase
3.9
81
70
NADENADEQ6IA69Q6IA69"denovoNADbiosyntheticprocess"NADbiosyntheticprocess
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
3.9
73
77
AL4A1AL4A1P30038P300384-hydroxyprolinecatabolicprocessprolinecatabolicprocessprolinecatabolicprocesstoglutamateprolinemetabolicprocess
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
3.9
83
66
PK3CDPK3CDO00329O00329adaptiveimmuneresponseBcellactivationBcellchemotaxisBcelldifferentiationBcellreceptorsignalingpathwaycellmigrationimmuneresponseinflammatoryresponseinnateimmuneresponsemastcellchemotaxismastcelldegranulationmastcelldifferentiationnaturalkillercellactivationnaturalkillercellchemotaxisnaturalkillercelldifferentiationneutrophilchemotaxisneutrophilextravasationphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationpositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcytokineproductionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialtubeformationpositiveregulationofgeneexpressionpositiveregulationofneutrophilapoptoticprocesspositiveregulationofproteinkinaseBsignalingproteinphosphorylationrespiratoryburstinvolvedindefenseresponsesignaltransductionTcellactivationTcellchemotaxisTcelldifferentiationTcellreceptorsignalingpathway
Leukotriene A-4 hydrolase
4.2
78
67
LKHA4LKHA4Q6IAT6Q6IAT6leukotrienebiosyntheticprocesslipidmetabolicprocesspeptidecatabolicprocessproteinmetabolicprocessproteolysisresponsetopeptidehormoneresponsetozinciontypeIpneumocytedifferentiation
RAF proto-oncogene serine/threonine-protein kinase
3.9
46
84
RAF1RAF1P04049P04049activationofadenylatecyclaseactivityapoptoticprocesscelldifferentiationdeath-inducingsignalingcomplexassemblyextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsfacedevelopmentinsulinreceptorsignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusinsulin-likegrowthfactorreceptorsignalingpathwayintermediatefilamentcytoskeletonorganizationMAPKcascadenegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofprotein-containingcomplexassemblyneurotrophinTRKreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofapoptoticprocessregulationofcelldifferentiationregulationofcellmotilityregulationofRhoproteinsignaltransductionresponsetomusclestretchsignaltransductionsomaticstemcellpopulationmaintenancethymusdevelopmentthyroidglanddevelopmenttypeBpancreaticcellproliferationwoundhealing
V-type proton ATPase subunit e 2
3.9
75
66
VA0E2VA0E2Q5EB76Q5EB76protontransmembranetransportsynapticvesiclelumenacidificationtransmembranetransport
Histone-lysine N-methyltransferase 2D
4.0
45
87
KMT2DKMT2DO14686O14686beta-catenin-TCFcomplexassemblyheterochromatinformationhistoneH3-K4dimethylationhistoneH3-K4methylationhistoneH3-K4monomethylationhistoneH3-K4trimethylationoocytegrowthoogenesispositiveregulationofcellpopulationproliferationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionresponsetoestrogen
Splicing factor 3A subunit 2
3.9
64
80
SF3A2SF3A2Q15428Q15428"mRNA3-splicesiterecognition"mRNAprocessingmRNAsplicingviaspliceosomepositiveregulationofneuronprojectiondevelopmentspliceosomalcomplexassemblyU2-typeprespliceosomeassembly
V(D)J recombination-activating protein 2
3.8
51
93
RAG2RAG2P21784P21784BcelldifferentiationBcellhomeostaticproliferationBcelllineagecommitmentchromatinorganizationdefenseresponsetobacteriumDN2thymocytedifferentiationDNArecombinationmatureBcelldifferentiationinvolvedinimmuneresponsenegativeregulationofTcelldifferentiationinthymusorgangrowthpositiveregulationoforgangrowthpre-BcellallelicexclusionTcelldifferentiationTcelldifferentiationinthymusTcelllineagecommitmentV(D)Jrecombination
ATP-dependent RNA helicase DHX58
4.4
67
77
DHX58DHX58Q96C10Q96C10antiviralinnateimmuneresponsecytosolicpatternrecognitionreceptorsignalingpathwaynegativeregulationofinnateimmuneresponsenegativeregulationofMDA-5signalingpathwaynegativeregulationofRIG-IsignalingpathwaynegativeregulationoftypeIinterferonproductionpositiveregulationofMDA-5signalingpathwaypositiveregulationofRIG-IsignalingpathwaypositiveregulationoftypeIinterferonproductionregulationofinnateimmuneresponseresponsetobacteriumresponsetovirus
28S ribosomal protein S28, mitochondrial
3.9
73
74
RT28RT28Q9Y2Q9Q9Y2Q9mitochondrialtranslation
Translation initiation factor eIF-2B subunit gamma
3.9
52
79
✔
EI2BGEI2BGQ9NR50Q9NR50cytoplasmictranslationalinitiationoligodendrocytedevelopmentresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiation
Fatty acid binding protein 5, epidermal
3.9
62
78
Q497I3Q497I3Q497I3Q497I3lipidtransportacrossblood-brainbarrier
V-type proton ATPase subunit e 1
3.9
72
69
VA0E1VA0E1O15342O15342protontransmembranetransportregulationofmacroautophagytransmembranetransportvacuolaracidification
Anaphase-promoting complex subunit 5
3.9
87
66
APC5APC5Q9UJX4Q9UJX4anaphase-promotingcomplex-dependentcatabolicprocesscellcyclecelldivisionpositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycle
Fermitin family homolog 2
3.9
73
71
FERM2FERM2Q96AC1Q96AC1adherensjunctionmaintenancecelladhesioncell-matrixadhesionfocaladhesionassemblyintegrinactivationintegrin-mediatedsignalingpathwaylimbdevelopmentnegativeregulationofcelldeathnegativeregulationoffatcelldifferentiationnegativeregulationofvascularpermeabilitypositiveregulationofcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascadepositiveregulationoffocaladhesionassemblypositiveregulationofGTPaseactivitypositiveregulationofintegrinactivationpositiveregulationofmesenchymalstemcellproliferationpositiveregulationofmyosinlightchainkinaseactivitypositiveregulationofosteoblastdifferentiationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofwoundhealingspreadingofepidermalcellsproteinlocalizationtocelljunctionproteinlocalizationtomembraneregulationofcellmorphogenesisregulationofcellshapesubstrateadhesion-dependentcellspreadingtransforminggrowthfactorbetareceptorsignalingpathwayWntsignalingpathway
NACHT, LRR and PYD domains-containing protein 3
2.2
49
84
NLRP3NLRP3Q96P20Q96P20apoptoticprocesscellularresponsetolipopolysaccharidecellularresponsetovirusdefenseresponsedetectionofbioticstimulusinflammatoryresponseinnateimmuneresponsenegativeregulationofacuteinflammatoryresponsenegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-1betaproductionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNIK/NF-kappaBsignalingNLRP3inflammasomecomplexassemblyosmosensorysignalingpathwaypatternrecognitionreceptorsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-4productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofT-helper2cellcytokineproductionpositiveregulationofT-helper2celldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftype2immuneresponseproteinhomooligomerizationpyroptosisregulationofinflammatoryresponsesignaltransduction
Kelch-like protein 7
4.1
63
77
KLHL7KLHL7Q8IXQ5Q8IXQ5proteinubiquitination
28S ribosomal protein S18c, mitochondrial
3.9
51
78
RT18CRT18CQ9Y3D5Q9Y3D5mitochondrialtranslationtranslation
Potassium voltage-gated channel subfamily KQT member 4
3.9
67
76
KCNQ4KCNQ4P56696P56696innerearmorphogenesispotassiumiontransmembranetransportpotassiumiontransportregulationofiontransmembranetransportsensoryperceptionofsound
Cyclic nucleotide-gated cation channel beta-1
3.9
71
70
CNGB1CNGB1Q14028Q14028cationtransmembranetransportcationtransportdetectionofchemicalstimulusinvolvedinsensoryperceptionofsmelldetectionoflightstimulusinvolvedinvisualperceptionionchannelmodulatingGprotein-coupledreceptorsignalingpathwaymembranedepolarizationolfactorynervematurationphotoreceptorcellmaintenancephotoreceptorcelloutersegmentorganizationphototransductionpositiveregulationofgeneexpressionproteinlocalizationtoorganelleresponsetoodorantretinahomeostasisvisualperception
Spliceosome-associated protein CWC27 homolog
3.9
68
74
CWC27CWC27Q6UX04Q6UX04mRNAsplicingviaspliceosomeproteinfoldingproteinpeptidyl-prolylisomerization
F-box/WD repeat-containing protein 11
3.9
62
75
✔
FBW1BSKP1Q9UKB1P63208brainmorphogenesisestablishmentofmitoticspindleorientationgermcelldevelopmentmicrotubuleorganizingcenterorganizationnegativeregulationofDNA-templatedtranscriptionnuclearmigrationpositiveregulationofcircadianrhythmpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteolysisproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindephosphorylationproteindestabilizationproteinpolyubiquitinationproteinubiquitinationretrogradeaxonaltransportrhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessvesicletransportalongmicrotubuleWntsignalingpathwaychromatinremodelingmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinmonoubiquitination
DNA polymerase eta
3.9
36
91
POLHPOLHQ9Y253Q9Y253cellularresponsetoUV-CDNArepairDNAreplicationDNAsynthesisinvolvedinDNArepairerror-freetranslesionsynthesiserror-pronetranslesionsynthesispyrimidinedimerrepairregulationofDNArepairresponsetoradiationresponsetoUV-C
rRNA methyltransferase 2, mitochondrial
3.9
84
69
MRM2MRM2Q9UI43Q9UI43mitochondriallargeribosomalsubunitassemblyRNAmethylation"rRNA2-O-methylation"rRNAmethylationrRNAprocessing
Cysteine protease ATG4A
3.9
72
69
ATG4AATG4AQ8WYN0Q8WYN0autophagylipidmetabolicprocessproteindelipidationproteintransportproteolysis
SLC2A4 regulator
4.0
44
85
S2A4RS2A4RQ9NR83Q9NR83regulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Deoxycytidylate deaminase
3.9
69
86
DCTDDCTDP32321P32321dTMPbiosyntheticprocessdUMPbiosyntheticprocesspyrimidinenucleotidemetabolicprocess
Zinc finger CCCH domain-containing protein 7A
3.9
47
89
✔
Z3H7AZ3H7AQ8IWR0Q8IWR0miRNAprocessingpost-transcriptionalregulationofgeneexpression
Ubiquitin-protein ligase E3A
4.0
47
84
UBE3AUBE3AQ05086Q05086androgenreceptorsignalingpathwaybraindevelopmentcellularresponsetobrain-derivedneurotrophicfactorstimuluslocomotoryexplorationbehaviormodulationofchemicalsynaptictransmissionmotorlearningnegativeregulationofdendriticspinemorphogenesisovarianfollicledevelopmentpositiveregulationofGolgilumenacidificationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinubiquitinationpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayprostateglandgrowthproteinautoubiquitinationproteinK48-linkedubiquitinationproteinpolyubiquitinationproteolysisregulationofcircadianrhythmregulationofubiquitin-dependentproteincatabolicprocessresponsetococaineresponsetohydrogenperoxideresponsetoprogesteronerhythmicprocessspermentryubiquitin-dependentproteincatabolicprocess
Hypermethylated in cancer 2 protein
3.9
39
90
HIC2HIC2Q96JB3Q96JB3negativeregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Replication factor C subunit 4
3.9
83
71
RFC4RFC4P35249P35249DNAduplexunwindingDNArepairDNAstrandelongationinvolvedinDNAreplicationDNA-templatedDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivity
Ankyrin repeat family A protein 2
3.9
82
73
ANRA2ANRA2Q9H9E1Q9H9E1regulationofgeneexpressionregulationofprotein-containingcomplexassembly
F-box/LRR-repeat protein 5
3.9
79
75
FBXL5FBXL5Q9UKA1Q9UKA1ironionhomeostasispositiveregulationofproteincatabolicprocessproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Target of Myb1 membrane trafficking protein
3.9
67
85
TOM1TOM1O60784O60784autophagosome-lysosomefusionendocytosisendosomaltransportpositiveregulationofautophagosomematurationproteintransportregulationofendosomeorganizationsignaltransductionsubstratelocalizationtoautophagosome
Exosome complex component RRP45
3.9
90
66
EXOS9EXOS9Q06265Q06265exonucleolyticcatabolismofdeadenylatedmRNA"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"immuneresponsenuclearmRNAsurveillancenuclearpolyadenylation-dependentmRNAcatabolicprocessnuclearpolyadenylation-dependentrRNAcatabolicprocessnuclearpolyadenylation-dependenttRNAcatabolicprocessnuclear-transcribedmRNAcatabolicprocess"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5"positiveregulationofcellgrowthpositiveregulationoftranscriptionbyRNApolymeraseIIRNAcatabolicprocessRNAprocessingrRNAcatabolicprocessrRNAprocessing"U1snRNA3-endprocessing""U4snRNA3-endprocessing""U5snRNA3-endprocessing"
Dihydropyrimidine dehydrogenase [NADP(+)]
3.6
41
81
DPYDDPYDQ28943Q28943beta-alaninebiosyntheticprocessthymidinecatabolicprocessuracilcatabolicprocess
Copper transport protein ATOX1
4.0
65
86
✔
ATOX1ATOX1O00244O00244cellularcopperionhomeostasiscopperiontransportresponsetooxidativestress
Inhibitor of growth protein 2
3.9
52
87
ING2ING2Q9ESK4Q9ESK4chromatinorganizationflagellatedspermmotilitymalegerm-linestemcellasymmetricdivisionmalemeiosisInegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofhistonedeacetylationpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofDNA-templatedtranscriptionseminiferoustubuledevelopmentspermatiddevelopmentspermatogenesis
DNA polymerase alpha subunit B
5.0
65
71
✔
DPOLADPOA2P09884Q14181DNArepairDNAreplicationDNAreplicationinitiationDNAreplicationsynthesisofRNAprimerDNAstrandelongationinvolvedinDNAreplicationDNAsynthesisinvolvedinDNArepairdouble-strandbreakrepairvianonhomologousendjoininglaggingstrandelongationleadingstrandelongationmitoticDNAreplicationinitiationregulationoftypeIinterferonproductionproteinimportintonucleus
Proton-activated chloride channel
3.9
58
84
PACC1PACC1Q9H813Q9H813chloridetransport
Immunoglobulin lambda variable 1-36
3.9
92
70
LV136LV136A0A0B4J1U3A0A0B4J1U3adaptiveimmuneresponseimmuneresponse
Protein DDI1 homolog 1
3.9
57
74
DDI1DDI1Q8WTU0Q8WTU0cellularresponsetohydroxyureaproteasomalproteincatabolicprocessregulationofDNAstabilityregulationofproteinstability
Fructose-bisphosphate aldolase
3.9
87
71
A6QLL8A6QLL8A6QLL8A6QLL8glycolyticprocess
2-oxoglutarate dehydrogenase complex component E1
3.9
81
71
✔
ODO1ODO1Q02218Q022182-oxoglutaratemetabolicprocesscerebellarcortexdevelopmentgenerationofprecursormetabolitesandenergyglycolyticprocesshippocampusdevelopmenthistonesuccinylationNADHmetabolicprocessolfactorybulbmitralcelllayerdevelopmentpyramidalneurondevelopmentstriatumdevelopmentsuccinyl-CoAmetabolicprocesstangentialmigrationfromthesubventricularzonetotheolfactorybulbthalamusdevelopmenttricarboxylicacidcycle
Calcium/calmodulin-dependent protein kinase type 1G
3.9
85
69
KCC1GKCC1GQ96NX5Q96NX5peptidyl-serinephosphorylation
2'-5'-oligoadenylate synthase-like protein
3.9
73
79
OASLOASLQ15646Q15646defenseresponsetovirusinnateimmuneresponseinterleukin-27-mediatedsignalingpathwaynegativeregulationofviralgenomereplicationpositiveregulationofRIG-Isignalingpathwayregulationofribonucleaseactivityresponsetovirus
Glutamate decarboxylase-like 1
3.9
83
71
E9QP13E9QP13E9QP13E9QP13carboxylicacidmetabolicprocess
E3 ubiquitin-protein ligase CBL-C
3.9
71
72
CBLCCBLCQ9ULV8Q9ULV8cellsurfacereceptorsignalingpathwaynegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofepidermalgrowthfactor-activatedreceptoractivitynegativeregulationofMAPkinaseactivityproteinubiquitinationsignaltransductionubiquitin-dependentproteincatabolicprocess
Sex comb on midleg-like protein 2
3.9
65
69
SCML2SCML2Q9UQR0Q9UQR0anatomicalstructuremorphogenesisnegativeregulationofDNA-templatedtranscription
Zinc finger BED domain-containing protein 2
3.9
42
81
ZBED2ZBED2Q9BTP6Q9BTP6negativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofkeratinocytedifferentiationregulationoftranscriptionbyRNApolymeraseII
Kinesin-like protein KIF2A
3.9
73
79
KIF2AKIF2AO00139O00139celldifferentiationcelldivisionmicrotubulecytoskeletonorganizationmicrotubuledepolymerizationmicrotubule-basedmovementmitoticspindleassemblymitoticspindleorganizationnervoussystemdevelopmentregulationofcellmigration
Inhibitor of growth protein 1
4.0
39
88
ING1ING1Q9UK53Q9UK53cellcyclenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofstemcellpopulationmaintenanceproteinimportintonucleusregulationofcelldeathregulationofDNA-templatedtranscription
Zinc finger protein Helios
3.9
70
64
IKZF2IKZF2Q9UKS7Q9UKS7regulationoftranscriptionbyRNApolymeraseII
Caspase recruitment domain-containing protein 18
3.9
54
77
CAR18CAR18P57730P57730inflammatoryresponseinhibitionofcysteine-typeendopeptidaseactivitynegativeregulationofinterleukin-1betaproductionnegativeregulationofproteinbindingproteolysisregulationofapoptoticprocess
Prolyl endopeptidase-like
3.9
87
68
PPCELPPCELQ4J6C6Q4J6C6GolgitoplasmamembraneproteintransportproteolysisregulationofsynapticvesicleexocytosisretrogradetransportendosometoGolgi
60S ribosomal protein L30
3.9
68
78
✔
RL30RL30P62888P62888antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecytoplasmictranslationdefenseresponsetoGram-negativebacteriumkillingofcellsofanotherorganismtranslation
Tumor necrosis factor ligand superfamily member 10
3.9
86
81
TNF10TNF10P50591P50591apoptoticprocesscell-cellsignalingimmuneresponsemalegonaddevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofreleaseofcytochromecfrommitochondriaresponsetoinsulinsignaltransduction
N-formyl peptide receptor 2
4.0
60
73
FPR2FPR2P25090P25090adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayastrocyteactivationcalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betachemotaxiscomplementreceptormediatedsignalingpathwaydefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinflammatoryresponsemicroglialcellactivationnegativeregulationofinflammatoryresponsephospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositivechemotaxispositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofinnateimmuneresponsepositiveregulationofmonocytechemotaxispositiveregulationofphagocytosispositiveregulationofproteinphosphorylationpositiveregulationofsuperoxideaniongenerationreceptor-mediatedendocytosis
Circadian locomoter output cycles protein kaput
4.0
56
78
CLOCKCLOCKO08785O08785cellularresponsetoionizingradiationcircadianregulationofgeneexpressioncircadianrhythmDNAdamagecheckpointsignalingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofglucocorticoidreceptorsignalingpathwaypositiveregulationofcircadianrhythmpositiveregulationofDNA-templatedtranscriptionpositiveregulationofinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinacetylationregulationofcircadianrhythmregulationofDNA-templatedtranscriptionregulationofhaircycleregulationofinsulinsecretionregulationoftranscriptionbyRNApolymeraseIIregulationoftypeBpancreaticcelldevelopmentresponsetoredoxstatespermatogenesis
Alpha-actinin-2
4.0
63
72
ACTN2ACTN2P35609P35609actincytoskeletonorganizationactinfilamentuncappingcardiacmusclecelldevelopmentcelladhesionfocaladhesionassemblymicrospikeassemblymusclecelldevelopmentnegativeregulationofpotassiumiontransmembranetransporteractivitynegativeregulationofpotassiumiontransportnegativeregulationofproteinlocalizationtocellsurfacephospholipaseC-activatingangiotensin-activatedsignalingpathwaypositiveregulationofcationchannelactivitypositiveregulationofendocyticrecyclingpositiveregulationofpotassiumiontransmembranetransporteractivitypositiveregulationofpotassiumiontransportproteinlocalizationtoplasmamembraneregulationofapoptoticprocessregulationofmembranepotentialsarcomereorganization
Ribosomal protein S6 kinase beta-1
4.0
55
78
KS6B1KS6B1Q7Z721Q7Z721agingapoptoticprocessbehavioralfearresponsecellmigrationcellularresponsetodexamethasonestimuluscellularresponsetogrowthfactorstimuluscellularresponsetoinsulinstimuluscellularresponsetotypeIIinterferonG1/Stransitionofmitoticcellcyclegermcelldevelopmentlong-chainfattyacidimportintocelllong-termmemorymodulationofchemicalsynaptictransmissionnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofinsulinreceptorsignalingpathwaypeptidyl-serinephosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofmitoticcellcyclepositiveregulationofskeletalmuscletissuegrowthpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranslationpositiveregulationoftranslationalinitiationproteinkinaseBsignalingregulationofglucoseimportresponsetoelectricalstimulusinvolvedinregulationofmuscleadaptationresponsetoethanolresponsetoglucagonresponsetoglucoseresponsetoheatresponsetoleucineresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetonutrientresponsetonutrientlevelsresponsetotestosteroneresponsetotoxicsubstanceresponsetotumornecrosisfactorresponsetowoundingresponsetoxenobioticstimulussignaltransductionskeletalmuscleatrophyskeletalmusclecontractionTORsignaling
Ryanodine receptor 2
4.0
81
68
RYR2RYR2Q9ERN6Q9ERN6calciumiontransmembraneimportintocytosolcalciumiontransmembranetransportcalciumiontransportcalciumiontransportintocytosolcalcium-mediatedsignalingcalcium-mediatedsignalingusingintracellularcalciumsourcecardiacmusclecontractioncardiacmusclehypertrophycellularcalciumionhomeostasiscellularresponsetocaffeinecellularresponsetoepinephrinestimulusdetectionofcalciumionembryonichearttubemorphogenesisestablishmentoflocalizationincellestablishmentofproteinlocalizationtoendoplasmicreticulumiontransmembranetransportleftventricularcardiacmuscletissuemorphogenesismanganeseiontransmembranetransportnegativeregulationofcytosoliccalciumionconcentrationpositiveregulationofATPase-coupledcalciumtransmembranetransporteractivitypositiveregulationofheartratepositiveregulationofsequesteringofcalciumionpositiveregulationoftheforceofheartcontractionPurkinjemyocytetoventricularcardiacmusclecellsignalingregulationofatrialcardiacmusclecellactionpotentialregulationofAVnodecellactionpotentialregulationofcardiacmusclecontractionregulationofcardiacmusclecontractionbycalciumionsignalingregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofcytosoliccalciumionconcentrationregulationofheartrateregulationofSAnodecellactionpotentialregulationofventricularcardiacmusclecellactionpotentialreleaseofsequesteredcalciumionintocytosolreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocaffeineresponsetocalciumionresponsetohypoxiaresponsetomagnesiumionresponsetomuscleactivityresponsetomusclestretchresponsetoredoxstatesarcoplasmicreticulumcalciumiontransporttypeBpancreaticcellapoptoticprocessventricularcardiacmusclecellactionpotential
Recombining binding protein suppressor of hairless
4.0
73
76
SUHMAML1Q06330Q92585angiogenesisaorticvalvedevelopmentarterialendothelialcellfatecommitmentatrioventricularcanaldevelopmentauditoryreceptorcellfatecommitmentBcelldifferentiationbloodvesselendothelialcellfatespecificationbloodvessellumenizationbloodvesselremodelingcardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationclubcelldifferentiationdefenseresponsetobacteriumdorsalaortamorphogenesisendocardiummorphogenesisepidermalcellfatespecificationepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationhairfolliclematurationhumoralimmuneresponseinflammatoryresponsetoantigenicstimuluskeratinocytedifferentiationlabyrinthinelayerbloodvesseldevelopmentmyeloiddendriticcelldifferentiationnegativeregulationofcelldifferentiationnegativeregulationofcold-inducedthermogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofossificationnegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIINotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayoutflowtractmorphogenesispituitaryglanddevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwayinvolvedincardiacmusclecellfatecommitmentpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofephrinreceptorsignalingpathwaypositiveregulationofepithelialcellproliferationpositiveregulationofERBBsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpulmonaryvalvedevelopmentregulationofreproductiveprocessregulationoftimingofcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIsebaceousglanddevelopmentsecondaryheartfieldspecificationsomaticstemcellpopulationmaintenancesomitogenesisstemcellproliferationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesisatrioventricularnodecelldevelopmentatrioventricularnodedevelopmentmyoblastdifferentiationpositiveregulationofmyotubedifferentiationproteinphosphorylation
DNA polymerase lambda
4.0
35
81
DPOLLDPOLLQ9UGP5Q9UGP5base-excisionrepairgap-fillingDNAbiosyntheticprocessDNAreplicationdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningnucleotide-excisionrepairsomatichypermutationofimmunoglobulingenes
Zinc finger protein 24
4.0
38
88
ZNF24ZNF24P17028P17028myelinationnegativeregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
4.0
87
67
AT2A2AT2A2P11607P11607autophagosomeassemblyautophagosomemembranedockingcalciumionimportintosarcoplasmicreticulumcalciumiontransmembranetransportcalciumiontransportfromcytosoltoendoplasmicreticulumcardiacmusclehypertrophyinresponsetostresscellularcalciumionhomeostasiscellularresponsetooxidativestressER-nucleussignalingpathwayiontransmembranetransportmitochondrion-endoplasmicreticulummembranetetheringnegativeregulationofheartcontractionnegativeregulationofreceptorbindingneuroncellularhomeostasisorganellelocalizationbymembranetetheringpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofendoplasmicreticulumcalciumionconcentrationregulationofcalciumion-dependentexocytosisofneurotransmitterregulationofcardiacmusclecontractionbycalciumionsignalingregulationoftheforceofheartcontractionT-tubuleorganizationtransitionbetweenfastandslowfiber
Orexin receptor type 2
2.0
66
85
Q548Y0Q548Y0Q548Y0Q548Y0circadiansleep/wakecycleprocessfeedingbehavior
Pre-mRNA processing factor 39
4.0
76
69
E9QJV4E9QJV4E9QJV4E9QJV4RNAprocessing
Ketohexokinase
4.0
99
63
A0A0J9YU79A0A0J9YU79A0A0J9YU79A0A0J9YU79fructosemetabolicprocess
Cytoglobin
5.3
53
69
CYGBCYGBQ8WWM9Q8WWM9fattyacidoxidationnegativeregulationofcollagenbiosyntheticprocessnegativeregulationoffibroblastmigrationnegativeregulationofhepaticstellatecellactivationoxygentransportresponsetohypoxiaresponsetooxidativestress
Zinc finger and BTB domain-containing protein 24
4.0
38
90
ZBT24ZBT24Q80X44Q80X44hematopoieticprogenitorcelldifferentiationregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Calcium-binding and coiled-coil domain-containing protein 2
4.0
39
85
CACO2CACO2Q13137Q13137positiveregulationofautophagosomematurationresponsetotypeIIinterferonviralprocessxenophagy
Nicotinamide phosphoribosyltransferase
4.0
80
71
NAMPTNAMPTP43490P43490cell-cellsignalingcircadianregulationofgeneexpressionNADbiosynthesisvianicotinamideribosidesalvagepathwayNADbiosyntheticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIsignaltransduction
Glutaredoxin-1
4.0
52
81
✔
GLRX1GLRX1P35754P35754nucleobase-containingsmallmoleculeinterconversionpositiveregulationofmembranepotentialpositiveregulationofsodiumiontransmembranetransporteractivityproteindeglutathionylation
Actin-related protein 8
4.0
78
62
ARP8ARP8Q9H981Q9H981cellcyclecelldivisionchromatinremodelingDNArecombinationdouble-strandbreakrepairpositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftelomeremaintenanceinresponsetoDNAdamageregulationofcellcycleregulationofchromosomeorganizationregulationofDNArepairregulationofDNAreplicationregulationofDNAstrandelongationregulationofDNA-templatedtranscriptionregulationofembryonicdevelopmenttelomeremaintenance
Protein argonaute-1
4.0
70
76
AGO1AGO1Q9UL18Q9UL18miRNAprocessingmiRNA-mediatedgenesilencingbyinhibitionoftranslationnegativeregulationofangiogenesisnuclear-transcribedmRNAcatabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpre-miRNAprocessingRISCcomplexassemblyRNAsecondarystructureunwinding
Glutamine synthetase
4.0
84
71
GLNAGLNAQ8HZM5Q8HZM5angiogenesisglutaminebiosyntheticprocessproteinpalmitoylationregulationofendothelialcellmigrationregulationofsproutingangiogenesis
cDNA FLJ40872 fis, clone TUTER2000283, highly similar to Homo sapiens transformer-2-beta (SFRS10) gene
4.0
67
73
Q8N1H4Q8N1H4Q8N1H4Q8N1H4
Cytohesin-2
4.0
66
73
CYH2CYH2Q99418Q99418actincytoskeletonorganizationendocytosisregulationofARFproteinsignaltransduction
Regucalcin
4.0
101
62
RGNRGNQ15493Q15493agingcellularcalciumionhomeostasiskidneydevelopmentL-ascorbicacidbiosyntheticprocessliverregenerationnegativeregulationofapoptoticprocessnegativeregulationofbonedevelopmentnegativeregulationofcalcium-dependentATPaseactivitynegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNAcatabolicprocessnegativeregulationofepithelialcellproliferationnegativeregulationofflagellatedspermmotilitynegativeregulationofGTPaseactivitynegativeregulationofleucine-tRNAligaseactivitynegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationofproteinkinaseactivitynegativeregulationofRNAbiosyntheticprocesspositiveregulationofATP-dependentactivitypositiveregulationofATPase-coupledcalciumtransmembranetransporteractivitypositiveregulationofdUTPdiphosphataseactivitypositiveregulationoffattyacidbiosyntheticprocesspositiveregulationofglucosemetabolicprocesspositiveregulationofGTPaseactivitypositiveregulationofphosphataseactivitypositiveregulationofproteolysisinvolvedinproteincatabolicprocesspositiveregulationofsuperoxidedismutaseactivitypositiveregulationoftriglyceridebiosyntheticprocessregulationofcalcium-mediatedsignalingspermatogenesis
17-beta-hydroxysteroid dehydrogenase 14
2.0
70
79
DHB14DHB14Q9BPX1Q9BPX1steroidcatabolicprocess
Protein kinase C beta type
4.0
44
84
KPCBKPCBP68403P68403adaptiveimmuneresponseapoptoticprocessBcellactivationBcellreceptorsignalingpathwaycalciumiontransportcellularcalciumionhomeostasiscellularresponsetocarbohydratestimuluschromatinorganizationdibenzo-p-dioxinmetabolicprocessintracellularsignaltransductionnegativeregulationofglucosetransmembranetransportnegativeregulationofinsulinreceptorsignalingpathwaypeptidyl-serinephosphorylationphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwaypositiveregulationofangiogenesispositiveregulationofBcellreceptorsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinsulinsecretionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofodontogenesisofdentin-containingtoothpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypost-translationalproteinmodificationpresynapticmodulationofchemicalsynaptictransmissionproteinphosphorylationregulationofdopaminesecretionregulationofglucosetransmembranetransportregulationofgrowthregulationofsynapticvesicleexocytosisregulationoftranscriptionbyRNApolymeraseIIresponsetoethanolresponsetoglucoseresponsetovitaminDresponsetoxenobioticstimulus
E3 ubiquitin-protein ligase Itchy homolog
4.0
74
71
ITCHITCHQ96J02Q96J02apoptoticprocessCD4-positivealpha-betaTcellproliferationdefenseresponsetovirusinflammatoryresponseinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofdefenseresponsetovirusnegativeregulationofJNKcascadenegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftypeIinterferonproductionnucleotide-bindingoligomerizationdomaincontainingsignalingpathwaypositiveregulationofproteincatabolicprocesspositiveregulationofreceptorcatabolicprocesspositiveregulationofTcellanergyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinK29-linkedubiquitinationproteinK48-linkedubiquitinationproteinK63-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofcellgrowthregulationofhematopoieticstemcelldifferentiationregulationofproteindeubiquitinationTcellanergyubiquitin-dependentproteincatabolicprocessviralentryintohostcell
Eukaryotic elongation factor 2 kinase
4.0
73
63
EF2KEF2KO00418O00418cellularresponsetoanoxiacellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetocalciumioncellularresponsetocAMPcellularresponsetoinsulinstimulusnegativeregulationofapoptoticprocesspositiveregulationofdendriticspinemorphogenesispositiveregulationofendocytosispositiveregulationofsynapseassemblyproteinautophosphorylationregulationofproteinautophosphorylationregulationoftranslationatpostsynapseresponsetoischemiaresponsetoprolactintranslationalelongation
Kinesin-1 heavy chain
4.0
97
64
KINHKINHP33176P33176anterogradeaxonalproteintransportanterogradedendritictransportofneurotransmitterreceptorcomplexanterogradeneuronaldensecorevesicletransportaxonguidancecellularresponsetotypeIIinterferoncentrosomelocalizationcytoplasmorganizationcytoskeleton-dependentintracellulartransportlysosomelocalizationmicrotubule-basedmovementmitochondriontransportalongmicrotubulemitocytosisnaturalkillercellmediatedcytotoxicityplus-end-directedvesicletransportalongmicrotubulepositiveregulationofpotassiumiontransportpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofsynaptictransmissionGABAergicregulationofmembranepotentialretrogradeneuronaldensecorevesicletransportstressgranuledisassemblysynapticvesicletransportvesicletransportalongmicrotubule
Ribonuclease H2 subunit A
4.0
66
80
RNH2ARNH2AO75792O75792DNAreplicationDNAreplicationremovalofRNAprimermismatchrepairRNAcatabolicprocess
F-box only protein 31
4.4
60
76
FBX31FBX31Q5XUX0Q5XUX0anaphase-promotingcomplex-dependentcatabolicprocesscellularresponsetoDNAdamagestimulusmitoticG1DNAdamagecheckpointsignalingpositiveregulationofdendritemorphogenesispositiveregulationofneuronmigrationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
SEC14-like protein 3
4.0
69
78
S14L3S14L3Q9UDX4Q9UDX4
Alanine--tRNA ligase, mitochondrial
4.0
95
70
SYAMSYAMQ5JTZ9Q5JTZ9alanyl-tRNAaminoacylationmitochondrialalanyl-tRNAaminoacylationtRNAmodification
N-alpha-acetyltransferase 15, NatA auxiliary subunit
4.0
72
78
✔
NAA15NAA15Q9BXJ9Q9BXJ9angiogenesiscelldifferentiationN-terminalpeptidyl-methionineacetylationN-terminalproteinaminoacidacetylationnegativeregulationofapoptoticprocesspositiveregulationofDNA-templatedtranscriptionproteinstabilization
Thymidylate synthase
4.2
60
69
✔
TYSYTYSYP04818P04818agingcartilagedevelopmentcircadianrhythmdevelopmentalgrowthDNAbiosyntheticprocessdTMPbiosyntheticprocessdTTPbiosyntheticprocessintestinalepithelialcellmaturationliverregenerationmethylationnegativeregulationoftranslationresponsetocytokineresponsetoethanolresponsetofolicacidresponsetoglucocorticoidresponsetoorganophosphorusresponsetoprogesteroneresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulustetrahydrofolateinterconversionuracilmetabolicprocess
Calpain-5
4.0
97
60
CAN5CAN5O15484O15484proteolysissignaltransduction
Mitochondrial enolase superfamily member 1
4.0
83
63
ENOF1ENOF1Q7L5Y1Q7L5Y1aminoacidcatabolicprocesscarbohydratecatabolicprocesscellularcarbohydratecatabolicprocess
ADP-sugar pyrophosphatase
4.0
86
65
NUDT5NUDT5Q9UKK9Q9UKK9ATPgenerationfrompoly-ADP-D-ribosechromatinremodelingD-ribosecatabolicprocessnucleobase-containingsmallmoleculemetabolicprocessnucleosidephosphatemetabolicprocessnucleotidemetabolicprocessribonucleosidediphosphatecatabolicprocessribosephosphatemetabolicprocess
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
4.4
65
74
P3C2AP3C2AQ61194Q61194autophagosomeorganizationcellmigrationcellularresponsetostarvationendocytosisexocytosismacroautophagynegativeregulationofzinciontransmembranetransportphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationpositiveregulationofautophagypositiveregulationofcellmigrationinvolvedinsproutingangiogenesis
Thioredoxin-like protein 4A
4.0
65
76
TXN4ATXN4AP83876P83876cellcyclecelldivisionmRNAsplicingviaspliceosomeRNAsplicingviatransesterificationreactionsspliceosomalcomplexassembly
Mothers against decapentaplegic homolog
4.0
74
75
B7Z5N5B7Z5N5B7Z5N5B7Z5N5regulationofDNA-templatedtranscriptiontransforminggrowthfactorbetareceptorsignalingpathway
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
4.0
100
66
✔
GBB1GBB1P62873P62873adenylatecyclase-activatingdopaminereceptorsignalingpathwaycellpopulationproliferationcellularresponsetocatecholaminestimuluscellularresponsetoprostaglandinEstimulusGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayRasproteinsignaltransductionretinadevelopmentincamera-typeeyesensoryperceptionoftastesignaltransduction
Zinc finger protein 462
4.0
35
86
ZN462ZN462Q96JM2Q96JM2chromatinorganizationnegativeregulationofDNAbindingpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpression
Glutaminase liver isoform, mitochondrial
4.0
97
65
GLSLGLSLQ9UI32Q9UI32aminoacidmetabolicprocessglutamatebiosyntheticprocessglutaminecatabolicprocessreactiveoxygenspeciesmetabolicprocessregulationofapoptoticprocess
Syntaxin-binding protein 2
4.0
65
77
STXB2STXB2Q15833Q15833cellularresponsetotypeIIinterferonintracellularproteintransportleukocytemediatedcytotoxicityneurotransmittersecretionneutrophildegranulationregulationofmastcelldegranulationvesicledockinginvolvedinexocytosisvesicle-mediatedtransport
Myosin light chain kinase, smooth muscle
4.0
77
74
MYLKMYLKQ15746Q15746aortasmoothmuscletissuemorphogenesisblebassemblycellularhypotonicresponsepositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofwoundhealingproteinphosphorylationsmoothmusclecontractiontonicsmoothmusclecontraction
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
4.0
72
76
CMTR1CMTR1Q8N1G2Q8N1G27-methylguanosinemRNAcappingcap1mRNAmethylationmRNAmethylation
Kelch repeat and BTB domain-containing protein 12
4.0
99
72
KBTBCKBTBCQ3ZCT8Q3ZCT8
Fructose-bisphosphate aldolase C
4.0
86
71
ALDOCALDOCP09972P09972epithelialcelldifferentiationfructose16-bisphosphatemetabolicprocessfructosemetabolicprocessgluconeogenesisglycolyticprocess
Epithelial splicing regulatory protein 1
4.0
57
73
ESRP1ESRP1Q6NXG1Q6NXG1mRNAprocessingregulationofinnerearauditoryreceptorcellfatespecificationregulationofRNAsplicingRNAsplicing
A-kinase anchor protein 7 isoform gamma
4.0
69
73
AKA7GAKA7GQ9P0M2Q9P0M2modulationofchemicalsynaptictransmissionregulationofproteinkinaseAsignaling
ERI1 exoribonuclease 3
4.0
60
77
ERI3ERI3O43414O43414"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"
StAR-related lipid transfer protein 13
4.0
74
67
STA13STA13Q9Y3M8Q9Y3M8actincytoskeletonorganizationendothelialcellmigrationendothelialtubelumenextensionnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisregulationofRhoproteinsignaltransductionregulationofsmallGTPasemediatedsignaltransductionsignaltransduction
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
4.0
86
65
PK3CBPK3CBQ8BTI9Q8BTI9angiogenesisinvolvedinwoundhealingautophagycellmigrationcellularcalciumionhomeostasisembryoniccleavageendocytosisendothelialcellproliferationhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofhypoxia-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofproteinkinaseBsignalingnegativeregulationofsproutingangiogenesisnegativeregulationofvascularendothelialgrowthfactorsignalingpathwayphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationplateletactivationpositiveregulationofendothelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofneutrophilapoptoticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofRacproteinsignaltransductionregulationofcell-matrixadhesionresponsetoischemiasphingosine-1-phosphatereceptorsignalingpathway
Exosome complex component RRP43
4.4
85
63
EXOS8EXOS8Q96B26Q96B26exonucleolyticcatabolismofdeadenylatedmRNA"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"nuclearmRNAsurveillancenuclearpolyadenylation-dependentmRNAcatabolicprocessnuclearpolyadenylation-dependentrRNAcatabolicprocessnuclearpolyadenylation-dependenttRNAcatabolicprocess"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5"RNAcatabolicprocessRNAprocessingrRNAcatabolicprocess"U1snRNA3-endprocessing""U4snRNA3-endprocessing""U5snRNA3-endprocessing"
Phytanoyl-CoA dioxygenase, peroxisomal
4.0
87
68
PAHXPAHXO14832O148322-oxobutyratecatabolicprocess2-oxoglutaratemetabolicprocessfattyacidalpha-oxidationisoprenoidmetabolicprocessmethyl-branchedfattyacidmetabolicprocess
Triple functional domain protein
5.0
50
73
TRIOTRIOO75962O75962axonguidancenegativeregulationoffatcelldifferentiationneuronprojectionmorphogenesispostsynapticmodulationofchemicalsynaptictransmissionproteinphosphorylationregulationofsmallGTPasemediatedsignaltransductiontransmembranereceptorproteintyrosinephosphatasesignalingpathway
Death domain-associated protein 6
4.0
38
76
✔
DAXXDAXXQ9UER7Q9UER7androgenreceptorsignalingpathwaycellularresponsetocadmiumioncellularresponsetocopperioncellularresponsetodiamidecellularresponsetoheatcellularresponsetosodiumarsenitecellularresponsetounfoldedproteinchromatinremodelingextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsJNKcascadenegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnucleosomeassemblypositiveregulationofneurondeathpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationregulationofapoptoticprocessregulationofDNA-templatedtranscriptionregulationofgeneexpressionregulationofproteinubiquitination
Coatomer subunit gamma-1
4.0
79
69
COPG1COPG1P53620P53620intra-Golgivesicle-mediatedtransportintracellularproteintransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Spliceosome RNA helicase DDX39B
4.0
80
73
DX39BDX39BQ13838Q13838mRNAexportfromnucleusmRNAsplicingviaspliceosomenegativeregulationofDNAdamagecheckpointpositiveregulationofDNA-templatedtranscriptionelongationRNAexportfromnucleusRNAsecondarystructureunwindingRNAsplicingspliceosomalcomplexassemblyviralmRNAexportfromhostcellnucleus
Protein argonaute-4
4.0
73
77
AGO4AGO4Q9HCK5Q9HCK5malegonaddevelopmentmalemeioticnucleardivisionmiRNAmetabolicprocessmiRNAprocessingmiRNA-mediatedgenesilencingbyinhibitionoftranslationmRNAcatabolicprocessnegativeregulationofapoptoticprocesspre-miRNAprocessingregulationofcellmorphogenesisRISCcomplexassemblyRNAsecondarystructureunwindingsynaptonemalcomplexassembly
Vacuolar protein sorting-associated protein 33A
4.0
73
72
VP33AVP33AQ96AX1Q96AX1autophagosomematurationendosomalvesiclefusionendosometolysosometransportintracellularproteintransportlysosomelocalizationmelanosomelocalizationplateletformationregulationofdevelopmentalpigmentationregulationoflysosomallumenpHregulationofSNAREcomplexassemblyvesicle-mediatedtransport
Signal transducing adapter molecule 2
4.3
69
73
STAM2STAM2O75886O75886macroautophagymembranefissionmultivesicularbodyassemblyproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwaysignaltransduction
Heterogeneous nuclear ribonucleoprotein L
4.0
61
71
HNRPLHNRPLP14866P14866cellularresponsetoaminoacidstarvationcircadianrhythmmRNAprocessingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofmRNAsplicingviaspliceosomepositiveregulationofmRNAbindingpositiveregulationoftranslationregulationofalternativemRNAsplicingviaspliceosomeregulationofRNAsplicingresponsetopeptideRNAprocessing
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
4.0
88
71
W5NRY1W5NRY1W5NRY1W5NRY1
Acyl-CoA dehydrogenase family member 11
4.0
79
70
ACD11ACD11Q709F0Q709F0fattyacidbeta-oxidationfattyacidbeta-oxidationusingacyl-CoAdehydrogenase
Terminal uridylyltransferase 7
3.8
48
87
TUT7TUT7Q5VYS8Q5VYS8miRNAmetabolicprocessnegativeregulationoftranspositionRNA-mediatednuclear-transcribedmRNApoly(A)tailshorteningoocytematurationpolyuridylation-dependentmRNAcatabolicprocesspre-miRNAprocessing"RNA3uridylation""RNA3-endprocessing"
DNA polymerase subunit gamma-1
4.8
67
74
DPOG1DPOG1P54098P54098base-excisionrepairgap-fillingDNAmetabolicprocessDNA-templatedDNAreplicationmitochondrialDNAreplication
N-alpha-acetyltransferase 10
4.0
71
70
✔
NAA10NAA10P41227P41227chromosomeorganizationinternalproteinaminoacidacetylationN-terminalproteinaminoacidacetylationnegativeregulationofmaintenanceofmitoticsisterchromatidcohesioncentromericproteinacetylation
DNA-binding protein Ikaros
4.0
79
61
IKZF1IKZF1Q13422Q13422cellcyclechromatinorganizationerythrocytedifferentiationlymphocytedifferentiationmesodermdevelopmentnegativeregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha
4.0
103
64
NUD10NUD10Q8NFP7Q8NFP7"adenosine5-(hexahydrogenpentaphosphate)catabolicprocess"diadenosinehexaphosphatecatabolicprocessdiadenosinepentaphosphatecatabolicprocessdiphosphoinositolpolyphosphatemetabolicprocess
Transcription factor Sp1
3.7
39
88
SP1SP1P08047P08047cellularresponsetoestrogenstimuluscellularresponsetoinsulinstimuluscellularresponsetowortmannincellularresponsetozincionstarvationpositiveregulationbyhostofviraltranscriptionpositiveregulationofamyloid-betaformationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofhydrogensulfidebiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialcellproliferationregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIresponsetohydroperoxiderhythmicprocess
FYVE and coiled-coil domain-containing protein 1
4.0
65
73
FYCO1FYCO1Q9BQS8Q9BQS8plus-end-directedvesicletransportalongmicrotubulepositiveregulationofautophagosomematuration
Orexin receptor type 2
3.5
17
86
OX2ROX2RO43614O43614chemicalsynaptictransmissioncircadiansleep/wakecycleprocessfeedingbehaviorGprotein-coupledreceptorsignalingpathwaylocomotionneuropeptidesignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofcircadiansleep/wakecyclewakefulnessregulationofcytosoliccalciumionconcentration
Core histone macro-H2A.1
4.0
89
67
H2AYH2AYO75367O75367dosagecompensationepigeneticregulationofgeneexpressionestablishmentofproteinlocalizationtochromatinnegativeregulationofcellcycleG2/Mphasetransitionnegativeregulationofgeneexpressionepigeneticnegativeregulationofproteinlocalizationtochromosometelomericregionnegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofresponsetooxidativestressnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseInucleosomeassemblypositiveregulationofendodermalcelldifferentiationpositiveregulationofkeratinocytedifferentiationpositiveregulationofmaintenanceofmitoticsisterchromatidcohesionpositiveregulationofresponsetooxidativestressregulationoflipidmetabolicprocessregulationofNADmetabolicprocessregulationofresponsetooxidativestresstranscriptioninitiation-coupledchromatinremodeling
Poly(A)-specific ribonuclease PARN
4.0
77
69
PARNPARNQ8VDG3Q8VDG3"boxH/ACARNA3-endprocessing"miRNAcatabolicprocessncRNAdeadenylationnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaynuclear-transcribedmRNApoly(A)tailshortening"polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenanceviatelomeraseregulationoftelomeraseRNAlocalizationtoCajalbodyRNAphosphodiesterbondhydrolysisexonucleolytictelomeraseRNAstabilization
Choline O-acetyltransferase
4.0
83
71
CLATCLATP28329P28329acetylcholinebiosyntheticprocessneuromuscularsynaptictransmissionneurotransmittertransportphosphatidylcholinebiosyntheticprocess
AMSH-like protease
4.0
77
68
STALPSTALPQ96FJ0Q96FJ0proteindeubiquitinationproteinK63-linkeddeubiquitination
LINE-1 retrotransposable element ORF1 protein
4.3
64
86
LORF1LORF1Q9UN81Q9UN81transpositionRNA-mediated
Phosphatidylinositol 3-kinase regulatory subunit beta
4.0
67
72
P85BP85BO00459O00459BcelldifferentiationcellularglucosehomeostasiscellularresponsetoinsulinstimulusimmuneresponseinsulinreceptorsignalingpathwaynegativeregulationofMAPKcascadephosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofcelladhesionpositiveregulationofproteinimportintonucleuspositiveregulationoftranscriptionbyRNApolymeraseIIproteintransportregulationofactinfilamentpolymerizationregulationofautophagyregulationofphosphatidylinositol3-kinaseactivityregulationofproteinlocalizationtoplasmamembraneregulationofstressfiberassemblyresponsetoendoplasmicreticulumstressTcelldifferentiation
Protein numb homolog
4.0
83
67
NUMBNUMBP49757P49757adherensjunctionorganizationaxonogenesislateralventricledevelopmentnegativeregulationofproteinlocalizationtoplasmamembraneneuroblastdivisioninsubventricularzonepositiveregulationofcellmigrationpositiveregulationofneurogenesisregulationofpostsynapticneurotransmitterreceptorinternalization
ATP-dependent RNA helicase DDX42
4.0
78
69
DDX42DDX42Q86XP3Q86XP3proteinlocalizationregulationofapoptoticprocess
Importin subunit beta-1
4.3
75
78
✔
IMB1IMB1Q14974Q14974astralmicrotubuleorganizationestablishmentofmitoticspindlelocalizationestablishmentofproteinlocalizationmitoticchromosomemovementtowardsspindlepolemitoticmetaphaseplatecongressionmitoticspindleassemblyNLS-bearingproteinimportintonucleusproteinimportintonucleusRanproteinsignaltransductionribosomalproteinimportintonucleusRNAimportintonucleus
Germinal-center associated nuclear protein
4.0
77
77
GANPENY2O60318Q9NPA8mRNAexportfromnucleusnucleosomeorganizationpoly(A)+mRNAexportfromnucleusproteintransportsomatichypermutationofimmunoglobulingeneschromatinorganizationhistonedeubiquitinationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoter
Brefeldin A-inhibited guanine nucleotide-exchange protein 1
4.0
79
75
BIG1BIG1Q9Y6D6Q9Y6D6endomembranesystemorganizationexocytosisGolgiorganizationnegativeregulationofactinfilamentpolymerizationnegativeregulationofGTPaseactivitypositiveregulationofwoundhealingproteinglycosylationproteintransportregulationofARFproteinsignaltransductionregulationofestablishmentofcellpolarity
Bifunctional peptidase and arginyl-hydroxylase JMJD5
4.0
64
71
KDM8KDM8Q8N371Q8N371chromatinorganizationcircadianregulationofgeneexpressionG2/MtransitionofmitoticcellcyclehistoneH3-K36demethylationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofDNA-templatedtranscriptionproteindestabilizationproteolysis
Pantothenate kinase 2, mitochondrial
4.0
64
72
PANK2PANK2Q9BZ23Q9BZ23aerobicrespirationangiogenesiscoenzymeAbiosyntheticprocessmitochondrionmorphogenesispantothenatemetabolicprocessphosphorylationregulationofbileacidmetabolicprocessregulationoffattyacidmetabolicprocessregulationofmitochondrialmembranepotentialregulationoftriglyceridemetabolicprocessspermatiddevelopment
WD repeat-containing protein 48
4.0
65
75
WDR48WDR48Q8TAF3Q8TAF3cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviahomologousrecombinationembryonicorgandevelopmenthomeostasisofnumberofcellsmulticellularorganismgrowthpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofepithelialcellproliferationregulationofproteinmonoubiquitinationseminiferoustubuledevelopmentsinglefertilizationskeletalsystemmorphogenesisskindevelopmentspermatogenesis
Nucleolysin TIAR
4.1
64
77
TIARTIARQ01085Q01085apoptoticprocessdefenseresponsegermcelldevelopmentnegativeregulationofcellpopulationproliferationpositiveregulationofhipposignalingpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofstemcellproliferationregulationoftranscriptionbyRNApolymeraseIIstemcelldivisionstemcellproliferation
Growth arrest and DNA-damage-inducible 45 gamma
3.9
91
69
Q99M58Q99M58Q99M58Q99M58regulationofcellcycle
mRNA decay activator protein ZFP36
4.1
47
83
TTPTTPP22893P22893"3-UTR-mediatedmRNAdestabilization""3-UTR-mediatedmRNAstabilization"cellularresponsetoepidermalgrowthfactorstimuluscellularresponsetofibroblastgrowthfactorstimuluscellularresponsetoglucocorticoidstimuluscellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorhematopoieticstemcelldifferentiationintracellularsignaltransductionMAPKcascademiRNA-mediatedgenesilencingbyinhibitionoftranslationmRNAcatabolicprocessmRNAtransportmyeloidcelldifferentiationnegativeregulationoferythrocytedifferentiationnegativeregulationofhematopoieticstemcelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-2productionnegativeregulationofmyeloidcelldifferentiationnegativeregulationofpolynucleotideadenylyltransferaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviraltranscriptionnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaynuclear-transcribedmRNAcatabolicprocessdeadenylation-independentdecaynuclear-transcribedmRNApoly(A)tailshorteningp38MAPKcascadepositiveregulationofdeadenylation-independentdecappingofnuclear-transcribedmRNApositiveregulationoffatcelldifferentiationpositiveregulationofintracellularmRNAlocalizationpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofmRNAcatabolicprocesspositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNApoly(A)tailshorteningregulationofkeratinocyteapoptoticprocessregulationofkeratinocytedifferentiationregulationofkeratinocyteproliferationregulationofmRNAstabilityregulationoftranscriptionbyRNApolymeraseIIregulationoftumornecrosisfactorproductionresponsetostarvationresponsetowoundingRNAdestabilization
Aromatic-L-amino-acid decarboxylase
4.9
71
67
DDCDDCP20711P20711aminergicneurotransmitterloadingintosynapticvesicleaminoacidmetabolicprocesscatecholaminemetabolicprocesscellularresponsetoalkaloidcellularresponsetogrowthfactorstimuluscellularresponsetoxenobioticstimuluscircadianrhythmdopaminebiosyntheticprocessisoquinolinealkaloidmetabolicprocessmulticellularorganismagingphytoalexinmetabolicprocessresponsetopyrethroidserotoninbiosyntheticprocess
S-adenosylmethionine decarboxylase proenzyme
4.1
61
70
✔
DCAMDCAMP17707P17707polyaminemetabolicprocessS-adenosylmethioninemetabolicprocessspermidinebiosyntheticprocesssperminebiosyntheticprocess
Terminal uridylyltransferase 4
4.1
58
79
TUT4TUT4Q5TAX3Q5TAX3miRNAcatabolicprocessmiRNAmetabolicprocessnegativeregulationoftranspositionRNA-mediatednuclear-transcribedmRNApoly(A)tailshorteningoocytematurationpolyuridylation-dependentmRNAcatabolicprocesspre-miRNAprocessing"RNA3uridylation""RNA3-endprocessing"stemcellpopulationmaintenance
Thymidylate synthase
4.1
93
63
Q544L2Q544L2Q544L2Q544L2agingcartilagedevelopmentcircadianrhythmdevelopmentalgrowthdTMPbiosyntheticprocessdTTPbiosyntheticprocessintestinalepithelialcellmaturationliverregenerationmethylationresponsetocytokineresponsetoethanolresponsetofolicacidresponsetoglucocorticoidresponsetoorganophosphorusresponsetoprogesteroneresponsetotoxicsubstanceresponsetovitaminAresponsetoxenobioticstimulustetrahydrofolateinterconversionuracilmetabolicprocess
Cytohesin-1
4.1
67
74
CYH1CYH1Q15438Q15438establishmentofepithelialcellpolarityregulationofARFproteinsignaltransductionregulationofcelladhesionvesicle-mediatedtransport
Adenylosuccinate lyase
4.1
55
75
PUR8PUR8P30566P30566"denovoAMPbiosyntheticprocess""denovoIMPbiosyntheticprocess""denovoXMPbiosyntheticprocess"aerobicrespirationAMPbiosyntheticprocessAMPsalvageGMPbiosyntheticprocesspurinenucleotidebiosyntheticprocessresponsetohypoxiaresponsetomuscleactivityresponsetonutrientresponsetostarvation
NF-kappa-B inhibitor alpha
4.1
92
73
IKBAIKBAP25963P25963apoptoticprocessBcellreceptorsignalingpathwaycellularresponsetocoldcellularresponsetotumornecrosisfactorcytoplasmicsequesteringofNF-kappaBcytoplasmicsequesteringoftranscriptionfactorI-kappaBkinase/NF-kappaBsignalinglipopolysaccharide-mediatedsignalingpathwaynegativeregulationofDNAbindingnegativeregulationoflipidstoragenegativeregulationofmacrophagederivedfoamcelldifferentiationnegativeregulationofmyeloidcelldifferentiationnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNotchsignalingpathwayNotchsignalingpathwaynucleotide-bindingoligomerizationdomaincontaining1signalingpathwaynucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofcholesteroleffluxpositiveregulationofinflammatoryresponsepositiveregulationofproteinmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinimportintonucleusregulationofcellpopulationproliferationregulationofNIK/NF-kappaBsignalingresponsetoexogenousdsRNAresponsetomuramyldipeptideresponsetomusclestretchtoll-likereceptor4signalingpathwaytumornecrosisfactor-mediatedsignalingpathway
Signal transducing adapter molecule 1
4.1
72
81
STAM1STAM1Q92783Q92783macroautophagymembranefissionmultivesicularbodyassemblypositiveregulationofexosomalsecretionproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayregulationofextracellularexosomeassemblysignaltransduction
Wings apart-like protein homolog
4.1
85
70
WAPLWAPLQ7Z5K2Q7Z5K2celldivisionmitoticsisterchromatidsegregationnegativeregulationofchromatinbindingnegativeregulationofDNAreplicationnegativeregulationofsisterchromatidcohesionproteinlocalizationtochromatinregulationofcohesinloading
Importin subunit alpha-6
4.1
34
80
IMA6IMA6O15131O15131NLS-bearingproteinimportintonucleusproteinimportintonucleus
Tyrosine-protein kinase Fyn
4.1
22
81
FYNFYNP06241P06241activatedTcellproliferationadaptiveimmuneresponseaxonguidancecalciumiontransportcelldifferentiationcellularresponsetoamyloid-betacellularresponsetoglycinecellularresponsetohydrogenperoxidecellularresponsetoL-glutamatecellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetotransforminggrowthfactorbetastimulusdendritemorphogenesisdendriticspinemaintenancedetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainephrinreceptorsignalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosisfeedingbehaviorforebraindevelopmentheartprocessI-kappaBkinase/NF-kappaBsignalinginnateimmuneresponseintracellularsignaltransductionlearningleukocytemigrationmodulationofchemicalsynaptictransmissionnegativeregulationofdendriticspinemaintenancenegativeregulationofgeneexpressionnegativeregulationofhydrogenperoxidebiosyntheticprocessnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofoxidativestress-inducedcelldeathnegativeregulationofproteincatabolicprocessnegativeregulationofproteinubiquitinationneuronmigrationpeptidyl-tyrosinephosphorylationpositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofneurondeathpositiveregulationofneuronprojectiondevelopmentpositiveregulationofproteinlocalizationtomembranepositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteintargetingtomembranepositiveregulationoftyrosinephosphorylationofSTATproteinproteinautophosphorylationproteincatabolicprocessproteinphosphorylationproteinubiquitinationregulationofcalciumionimportacrossplasmamembraneregulationofcellshaperegulationofglutamatereceptorsignalingpathwayregulationofpeptidyl-tyrosinephosphorylationresponsetoamyloid-betaresponsetoethanolresponsetosingletoxygenstimulatoryC-typelectinreceptorsignalingpathwayTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
Endoplasmic reticulum resident protein 44
2.0
75
82
✔
PRDX4ERP44Q13162Q9BS26cellredoxhomeostasisextracellularmatrixorganizationI-kappaBphosphorylationmalegonaddevelopmentnegativeregulationofmalegermcellproliferationpeptidyl-prolinehydroxylationto4-hydroxy-L-prolineproteinmaturationbyproteinfoldingreactiveoxygenspeciesmetabolicprocessresponsetooxidativestressspermatogenesisglycoproteinmetabolicprocessproteinfoldingresponsetoendoplasmicreticulumstressresponsetounfoldedprotein
Protein lin-9 homolog
4.1
86
66
LIN9LIN37Q5TKA1Q96GY3cellcycleDNAbiosyntheticprocessDNA-templatedtranscriptionregulationofcellcycleregulationoftranscriptionbyRNApolymeraseIIreproductionnegativeregulationoftranscriptionbyRNApolymeraseII
Kinesin heavy chain isoform 5C
4.1
97
63
KIF5CKIF5CP28738P28738anterogradeaxonalproteintransportanterogradedendritictransportofmessengerribonucleoproteincomplexanterogradedendritictransportofneurotransmitterreceptorcomplexATPmetabolicprocessaxonguidancecytoskeleton-dependentintracellulartransportintracellularmRNAlocalizationmicrotubule-basedmovementmotorneuronaxonguidancemRNAtransportsynapticvesicletransport
Arginine--tRNA ligase, cytoplasmic
4.1
75
72
SYRCSYRCP54136P54136arginyl-tRNAaminoacylationtRNAaminoacylationforproteintranslation
Heterogeneous nuclear ribonucleoprotein L-like
4.1
64
71
HNRLLHNRLLQ8WVV9Q8WVV9mRNAprocessingpositiveregulationofRNAsplicingregulationofRNAsplicing
Protein XRP2
4.9
70
82
XRP2XRP2O75695O75695ciliumassemblypost-Golgivesicle-mediatedtransportproteinfoldingproteintransportvisualperception
Trifunctional enzyme subunit alpha, mitochondrial
4.1
81
65
ECHAECHAP40939P40939cardiolipinacyl-chainremodelingfattyacidbeta-oxidationresponsetoinsulinresponsetoxenobioticstimulus
Dual specificity tyrosine-phosphorylation-regulated kinase 2
4.1
77
69
DYRK2DYRK2Q92630Q92630cellularresponsetoDNAdamagestimulusintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofcalcineurin-NFATsignalingcascadepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofglycogenbiosyntheticprocessproteinphosphorylationregulationofsignaltransductionbyp53classmediatorsmoothenedsignalingpathway
RING-type E3 ubiquitin transferase
4.1
57
74
Q4R1Q4Q4R1Q4Q4R1Q4Q4R1Q4
Cytochrome P450 21-hydroxylase
4.1
86
67
Q16874Q16874Q16874Q16874
Telomeric repeat-binding factor 1
4.1
88
75
TERF1TERF1P54274P54274celldivisionmeiotictelomereclusteringnegativeregulationofDNAreplicationnegativeregulationofestablishmentofproteinlocalizationtotelomerenegativeregulationofestablishmentofprotein-containingcomplexlocalizationtotelomerenegativeregulationofestablishmentofRNAlocalizationtotelomerenegativeregulationofexonucleaseactivitynegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviasemi-conservativereplicationnegativeregulationoftelomeremaintenanceviatelomerasenegativeregulationoftelomeremaintenanceviatelomerelengtheningnegativeregulationoftelomericD-loopdisassemblypositiveregulationofshelterincomplexassemblypositiveregulationoftelomeremaintenanceresponsetoxenobioticstimulust-circleformationtelomerecappingtelomeremaintenancetelomeremaintenanceviatelomerasetelomericD-loopdisassembly
Lanosterol synthase
4.1
83
65
LSSLSSP48449P48449cholesterolbiosyntheticprocessregulationofproteinstabilitysteroidbiosyntheticprocesstriterpenoidbiosyntheticprocess
3'-5' exoribonuclease 1
4.1
61
77
ERI1ERI1Q8IV48Q8IV48"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"RNA-mediatedgenesilencing"rRNA3-endprocessing"
Pantothenate kinase 3
4.1
59
78
PANK3PANK3Q9H999Q9H999coenzymeAbiosyntheticprocessphosphorylation
Serine/threonine-protein kinase WNK3
4.1
86
65
WNK3WNK3Q9BYP7Q9BYP7cellvolumehomeostasisintracellularsignaltransductionionhomeostasismaintenanceofblood-brainbarriernegativeregulationofapoptoticprocessnegativeregulationofsodiumiontransportosmosensorysignalingpathwaypeptidyl-threoninephosphorylationpositiveregulationofcalciumiontransportpositiveregulationofiontransmembranetransporteractivitypositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpotassiumionimportacrossplasmamembranepositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofsodiumiontransmembranetransporteractivitypositiveregulationofsodiumiontransportproteinautophosphorylationproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofcalciumionimportregulationofcationtransmembranetransport
Aspartyl aminopeptidase
4.1
79
69
DNPEPDNPEPQ9ULA0Q9ULA0peptidemetabolicprocessproteolysis
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
4.1
83
69
ACADVACADVP49748P49748energyderivationbyoxidationoforganiccompoundsepithelialcelldifferentiationfattyacidbeta-oxidationusingacyl-CoAdehydrogenasenegativeregulationoffattyacidbiosyntheticprocessnegativeregulationoffattyacidoxidationregulationofcholesterolmetabolicprocessresponsetocoldtemperaturehomeostasis
Protein zer-1 homolog
4.1
66
72
ZER1ZER1Q7Z7L7Q7Z7L7positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinqualitycontrolformisfoldedorincompletelysynthesizedproteins
Branched-chain-amino-acid aminotransferase, cytosolic
4.1
80
57
BCAT1BCAT1P54687P54687branched-chainaminoacidbiosyntheticprocessG1/Stransitionofmitoticcellcycleleucinebiosyntheticprocesslipidmetabolicprocessvalinebiosyntheticprocess
Filamin-B
4.1
50
77
FLNBFLNBO75369O75369actincytoskeletonorganizationcellularresponsetotypeIIinterferonepithelialcellmorphogenesiskeratinocytedevelopmentsignaltransductionskeletalmuscletissuedevelopment
Nucleoporin SEH1
4.1
69
75
SEH1SEH1Q96EE3Q96EE3attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncellularresponsetoaminoacidstarvationdefenseresponsetoGram-positivebacteriummitoticmetaphaseplatecongressionmRNAtransportnegativeregulationofTORC1signalingnuclearporeorganizationnucleocytoplasmictransportpositiveregulationofTORsignalingpositiveregulationofTORC1signalingproteintransportprotein-containingcomplexlocalization
Numb-like protein
4.1
84
69
NUMBLNUMBLQ9Y6R0Q9Y6R0adherensjunctionorganizationaxonogenesiscytokine-mediatedsignalingpathwaylateralventricledevelopmentnervoussystemdevelopmentneuroblastdivisioninsubventricularzonepositiveregulationofneurogenesisproteinmetabolicprocess
Centromere protein I
4.1
52
77
CENPICENPIQ92674Q92674centromerecomplexassemblysexdifferentiation
Importin subunit alpha-5
4.1
80
68
✔
IMA5IMA5P52294P52294NLS-bearingproteinimportintonucleuspostsynapsetonucleussignalingpathwayproteinimportintonucleusregulationofapoptoticprocessregulationofcanonicalWntsignalingpathwayregulationofDNArecombinationsatellitecellactivationinvolvedinskeletalmuscleregenerationskeletalmusclesatellitecellproliferation
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
4.1
68
76
PUR6PUR6P22234P22234"denovoAMPbiosyntheticprocess""denovoIMPbiosyntheticprocess""denovoXMPbiosyntheticprocess"GMPbiosyntheticprocesspurinenucleobasebiosyntheticprocess
Cytoplasmic FMR1-interacting protein 1
4.4
63
74
CYFP1CYFP1Q7L576Q7L576axonextensionaxonguidancecellmorphogenesiscellprojectionassemblycellularresponsetoinsulinstimuluscognitiondendriteextensionlamellipodiumassemblymodificationofsynapticstructurenegativeregulationofsynapticvesiclerecyclingpositiveregulationofArp2/3complex-mediatedactinnucleationpositiveregulationofaxonextensionpositiveregulationofdendritedevelopmentpositiveregulationoflamellipodiumassemblypositiveregulationofneurotrophinTRKreceptorsignalingpathwaypositiveregulationofruffleassemblyRacproteinsignaltransductionregulationofactinfilamentpolymerizationregulationofcellshaperegulationofmodificationofpostsynapticactincytoskeletonregulationofmyelinationregulationoftranslationregulationoftranslationatpostsynapsemodulatingsynaptictransmissionresponsetoelectricalstimulusruffleorganization
PR domain-containing protein 11
4.1
39
76
PRD11PRD11Q9NQV5Q9NQV5methylationnegativeregulationofcellgrowthnegativeregulationofDNA-templatedtranscriptionpositiveregulationofDNA-templatedtranscriptionpositiveregulationoffibroblastapoptoticprocessregulationofcellcycleregulationofgeneexpressionregulationofMAPKcascade
Rab15 effector protein
4.1
71
69
REP15REP15Q6BDI9Q6BDI9receptorrecyclingtransferrintransport
Adenosylhomocysteinase 3
4.1
91
63
SAHH3SAHH3Q96HN2Q96HN2one-carbonmetabolicprocessS-adenosylmethioninecycle
Interleukin-34
2.0
56
89
IL34IL34Q8R1R4Q8R1R4inflammatoryresponseinnateimmuneresponseinterleukin-34-mediatedsignalingpathwaymicroglialcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofmacrophagechemotaxispositiveregulationofmacrophagedifferentiationpositiveregulationofmacrophageproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofmonocytedifferentiationpositiveregulationofoligodendrocytedifferentiationpositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivity
Exonuclease 3'-5' domain-containing protein 2
4.1
79
72
EXD2EXD2Q9NVH0Q9NVH0DNAdouble-strandbreakprocessingdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationnucleicacidphosphodiesterbondhydrolysisreplicationforkprocessing
Growth arrest and DNA damage-inducible protein GADD45 gamma
4.1
91
68
GA45GGA45GO95257O95257apoptoticprocesscelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationofcold-inducedthermogenesispositiveregulationofJNKcascadepositiveregulationofp38MAPKcascaderegulationofcellcycle
Short transient receptor potential channel 6
4.1
35
85
TRPC6TRPC6Q9Y210Q9Y210calciumiontransmembranetransportcationtransportpositiveregulationofcalciumiontransportpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofiontransmembranetransporteractivityregulationofcytosoliccalciumionconcentrationsinglefertilization
Ras-related GTP-binding protein A
4.1
78
81
RRAGARRAGAQ7L523Q7L523apoptoticprocesscelldeathcellularresponsetoaminoacidstarvationcellularresponsetoaminoacidstimuluscellularresponsetostarvationnegativeregulationofautophagypositiveregulationofTORsignalingpositiveregulationofTORC1signalingproteinlocalizationregulationofautophagytumornecrosisfactor-mediatedsignalingpathway
Deoxyuridine 5'-triphosphate nucleotidohydrolase
4.1
55
73
A0A480PG39A0A480PG39A0A480PG39A0A480PG39dUMPbiosyntheticprocessdUTPcatabolicprocess
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
4.1
80
71
FABDFABDQ8IVS2Q8IVS2fattyacidbeta-oxidationfattyacidbiosyntheticprocess
Splicing factor 3B subunit 1
4.1
86
68
✔
SF3B1SF3B1O75533O75533chromatinremodelingmRNAsplicingviaspliceosomepositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomalcomplexassemblyU2-typeprespliceosomeassembly
Actin, alpha skeletal muscle
4.1
79
69
ACTSACTSP68136P68136cellularresponsetoorganonitrogencompoundmesenchymemigrationpositiveregulationofgeneexpressionresponsetoextracellularstimulusresponsetolithiumionresponsetomechanicalstimulusresponsetosteroidhormoneskeletalmusclefiberadaptationskeletalmusclefiberdevelopmentskeletalmusclethinfilamentassembly
PTB domain-containing engulfment adapter protein 1
4.1
73
71
GULP1GULP1Q9UBP9Q9UBP9apoptoticprocesslipidtransportphagocytosisengulfment
Rho-related GTP-binding protein RhoE
3.4
68
79
RND3RND3P61587P61587actincytoskeletonorganizationactinfilamentorganizationcelladhesioncellmigrationcorticalcytoskeletonorganizationestablishmentormaintenanceofcellpolarityregulationofactincytoskeletonorganizationregulationofcellshapesmallGTPasemediatedsignaltransduction
Cleavage and polyadenylation specificity factor subunit 1
4.6
82
65
CPSF1CPSF1Q10570Q10570mRNApolyadenylationpre-mRNAcleavagerequiredforpolyadenylation
Actin-related protein 6
4.2
65
70
ARP6ARP6Q9GZN1Q9GZN1negativeregulationoftranscriptionbyRNApolymeraseInucleolusorganizationpositiveregulationoftranscriptionbyRNApolymeraseIregulationofDNA-templatedtranscription
Heat shock protein 75 kDa, mitochondrial
4.2
72
67
TRAP1TRAP1Q12931Q12931chaperone-mediatedproteinfoldingnegativeregulationofcellularrespirationnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetohydrogenperoxidenegativeregulationofreactiveoxygenspeciesbiosyntheticprocessproteinfoldingtranslationalattenuation
Protein arginine N-methyltransferase 3
3.5
55
91
ANM3ANM3Q922H1Q922H1dendriticspinemorphogenesisnegativeregulationofproteinubiquitinationnegativeregulationofretinoicacidbiosyntheticprocesspeptidyl-argininemethylationpeptidyl-argininemethylationtoasymmetrical-dimethylarginineproteinmethylation
HCG15971, isoform CRA_a
4.2
79
69
Q1KLZ0Q1KLZ0Q1KLZ0Q1KLZ0negativeregulationofproteinbindingregulationofsynapticvesicleendocytosis
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
4.2
75
70
HEM6HEM6P36551P36551hemebiosyntheticprocessprotoporphyrinogenIXbiosyntheticprocessresponsetoarsenic-containingsubstanceresponsetoinsecticideresponsetoironionresponsetoleadionresponsetomethylmercury
Isoform 2 of Disks large homolog 1
4.2
77
72
DLG1DLG1Q12959-2Q12959-2
Retinoblastoma-binding protein 5
4.2
88
68
RBBP5RBBP5Q15291Q15291cellularresponsetoDNAdamagestimulushistoneH3-K4methylationresponsetoestrogentranscriptioninitiation-coupledchromatinremodeling
Serine/threonine-protein kinase 32A
4.2
48
74
ST32AST32AQ8WU08Q8WU08intracellularsignaltransductionpeptidyl-serinephosphorylation
Indolethylamine N-methyltransferase
4.2
76
66
INMTINMTO95050O95050aminemetabolicprocessmethylationresponsetotoxicsubstance
Mas-related G-protein coupled receptor member X4
2.0
31
89
MRGX4MRGX4Q96LA9Q96LA9Gprotein-coupledreceptorsignalingpathway
Neuroepithelial cell-transforming gene 1 protein
4.2
69
69
ARHG8ARHG8Q7Z628Q7Z628cellularresponsetohydrogenperoxidecellularresponsetoionizingradiationintracellularsignaltransductionmyoblastmigrationpositiveregulationofapoptoticprocesspositiveregulationofGTPaseactivitypositiveregulationofRhoproteinsignaltransductionregulationofcellgrowthregulationofsmallGTPasemediatedsignaltransductionsignaltransduction
Autophagy-related protein 13
4.2
80
69
ATG13ATG13O75143O75143autophagosomeassemblymitophagynegativeregulationofcellpopulationproliferationpiecemealmicroautophagyofthenucleuspositiveregulationofautophagypositiveregulationofproteintargetingtomitochondrionproteinautophosphorylationproteinlocalizationtophagophoreassemblysiteproteinphosphorylationregulationofproteinlipidationresponsetomitochondrialdepolarisation
DIS3-like exonuclease 2
4.2
74
68
DI3L2DI3L2Q8CI75Q8CI75celldivisionmiRNAcatabolicprocessmitoticcellcyclemitoticsisterchromatidseparationmRNAcatabolicprocessnegativeregulationofcellpopulationproliferationnuclear-transcribedmRNAcatabolicprocessexonucleolytic"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5"polyuridylation-dependentmRNAcatabolicprocessstemcellpopulationmaintenance
Uroporphyrinogen decarboxylase
4.2
73
68
✔
DCUPDCUPP06132P06132hemebiosyntheticprocessporphyrin-containingcompoundcatabolicprocessporphyrin-containingcompoundmetabolicprocessprotoporphyrinogenIXbiosyntheticprocess
Voltage dependent anion channel 2
4.2
50
72
F1S2F6F1S2F6F1S2F6F1S2F6bindingofspermtozonapellucidamitochondrialoutermembranepermeabilizationnegativeregulationofintrinsicapoptoticsignalingpathwaynegativeregulationofproteinpolymerization
Actin gamma 1
4.2
78
69
I3LVD5I3LVD5I3LVD5I3LVD5
Speckle-type POZ protein
2.0
58
86
✔
SPOPSPOPO43791O43791localizationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationregulationofproteolysis
Eukaryotic translation initiation factor 3 subunit G
3.6
38
94
EIF3GEIF3GO75821O75821formationofcytoplasmictranslationinitiationcomplextranslationalinitiationviraltranslationaltermination-reinitiation
Cytochrome c
4.2
70
62
CYCCYCP99999P99999activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromeccellularrespirationintrinsicapoptoticsignalingpathwaymitochondrialelectrontransportcytochromectooxygenmitochondrialelectrontransportubiquinoltocytochromecpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocess
Fibroblast growth factor 7
4.2
56
77
FGF7FGF7Q02195Q02195actincytoskeletonreorganizationanimalorganmorphogenesisbranchinginvolvedinsalivaryglandmorphogenesiscelldifferentiationendothelialcellproliferationepithelialcellproliferationfibroblastgrowthfactorreceptorsignalingpathwayhairfolliclemorphogenesislungdevelopmentmesenchymalcellproliferationmyoblastproliferationovarianfollicledevelopmentphosphatidylcholinebiosyntheticprocessphospholipidbiosyntheticprocesspositivechemotaxispositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofepithelialcellproliferationinvolvedinlungmorphogenesispositiveregulationofgeneexpressionpositiveregulationofkeratinocytemigrationpositiveregulationofkeratinocyteproliferationpositiveregulationofmyoblastproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationproteinlocalizationtocellsurfaceregulationofbranchinginvolvedinsalivaryglandmorphogenesisbymesenchymal-epithelialsignalingregulationofcellmigrationsecretionbylungepithelialcellinvolvedinlunggrowthsurfactanthomeostasiswoundhealing
Nuclear factor NF-kappa-B p100 subunit
4.2
59
77
NFKB2NFKB2Q00653Q00653extracellularmatrixorganizationfolliculardendriticcelldifferentiationgerminalcenterformationnegativeregulationofmacromoleculemetabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIINIK/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIrhythmicprocessspleendevelopment
Ceramide-1-phosphate transfer protein
4.2
71
71
CPTPCPTPQ5TA50Q5TA50ceramide1-phosphatetransportceramidetransportglycosphingolipidmetabolicprocessintermembranelipidtransfernegativeregulationofautophagynegativeregulationofinterleukin-1betaproductionnegativeregulationofNLRP3inflammasomecomplexassembly
RWD domain-containing protein 2B
4.2
57
72
✔
RWD2BRWD2BP57060P57060
Pre-mRNA-splicing factor SYF1
4.2
74
74
SYF1SYF1Q9HCS7Q9HCS7blastocystdevelopmentcerebralcortexdevelopmentDNA-templatedtranscriptiongenerationofcatalyticspliceosomeforfirsttransesterificationstepmRNAsplicingviaspliceosometranscription-couplednucleotide-excisionrepair
Medulloblastoma antigen MU-MB-50.72
4.6
52
71
Q7Z5E2Q7Z5E2Q7Z5E2Q7Z5E2
Dihydropyrimidinase-related protein 4
4.2
75
66
DPYL4DPYL4O14531O14531nervoussystemdevelopment
Adenosylhomocysteinase
4.2
97
63
✔
SAHHSAHHP10760P10760chronicinflammatoryresponsetoantigenicstimuluscircadiansleep/wakecycleone-carbonmetabolicprocessresponsetohypoxiaresponsetonutrientS-adenosylhomocysteinecatabolicprocessS-adenosylmethioninecycle
Tyrosine-protein kinase ZAP-70
4.2
53
74
ZAP70ZAP70P43403P43403adaptiveimmuneresponseBcellactivationbetaselectioncalcium-mediatedsignalingcelldifferentiationimmuneresponseinnateimmuneresponseintracellularsignaltransductionnegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofalpha-betaTcellproliferationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofTcelldifferentiationpositivethymicTcellselectionproteinautophosphorylationproteinphosphorylationTcellactivationTcellaggregationTcelldifferentiationTcellmigrationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathway
HIV Tat-specific factor 1
4.2
72
71
HTSF1HTSF1O43719O43719mRNAsplicingviaspliceosomeregulationofDNA-templatedtranscriptionelongationregulationoftranscriptionbyRNApolymeraseIIU2-typeprespliceosomeassemblyviralgenomereplication
Selenocysteine-specific elongation factor
4.2
75
70
SELBSELBP57772P57772selenocysteineincorporationtranslationalelongation
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
4.3
83
63
PK3CAPK3CAP42336P42336actincytoskeletonorganizationadiposetissuedevelopmentangiogenesisanoikiscardiacmusclecellcontractioncardiacmusclecontractioncellmigrationcellularresponsetoglucosestimuluscellularresponsetohydrostaticpressureendothelialcellmigrationenergyhomeostasisepidermalgrowthfactorreceptorsignalingpathwayglucosemetabolicprocesshypomethylationofCpGislandinsulinreceptorsignalingpathwayviaphosphatidylinositol3-kinaseinsulin-likegrowthfactorreceptorsignalingpathwayliverdevelopmentnegativeregulationofactinfilamentdepolymerizationnegativeregulationofanoikisnegativeregulationoffibroblastapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofmacroautophagynegativeregulationofneuronapoptoticprocessphagocytosisphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationplateletactivationpositiveregulationoflamellipodiumassemblypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofsmoothmusclecellproliferationpositiveregulationofTORsignalingproteinkinaseBsignalingregulationofactinfilamentorganizationregulationofcellularrespirationregulationofgeneticimprintingregulationofmulticellularorganismgrowthrelaxationofcardiacmuscleresponsetoactivityresponsetobutyrateresponsetodexamethasoneresponsetoleucineresponsetomuscleinactivityresponsetomusclestretchTcellcostimulationTcellreceptorsignalingpathwayvascularendothelialgrowthfactorsignalingpathwayvasculaturedevelopment
HAUS augmin-like complex subunit 6
4.2
72
70
HAUS6HAUS6Q7Z4H7Q7Z4H7celldivisioncentrosomecyclemicrotubulecytoskeletonorganizationspindleassembly
Stress-induced-phosphoprotein 1
4.2
72
72
STIP1STIP1P31948P31948cellularresponsetointerleukin-7
Cyclin-T1
4.0
nan
86
✔
CCNT1A0A0C5HAL9O60563A0A0C5HAL9cellcyclecelldivisionphosphorylationofRNApolymeraseIIC-terminaldomainserine2residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterphosphorylationofRNApolymeraseIIC-terminaldomainserine5residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinphosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulustranscriptionbyRNApolymeraseIIpositiveregulationofviraltranscription
TEPSIN adaptor related protein complex 4 accessory protein
4.2
67
72
F6SIY5F6SIY5F6SIY5F6SIY5
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
4.3
78
67
STT3ASTT3AP46977P46977co-translationalproteinmodificationpost-translationalproteinmodificationproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagine
Tyrosine-protein kinase Fes/Fps
4.3
55
72
FESFESP07332P07332cardiacmusclecellproliferationcelladhesioncelldifferentiationcellularresponsetovitaminDcentrosomecyclechemotaxisinnateimmuneresponsemicrotubulebundleformationmyoblastproliferationpeptidyl-tyrosinephosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofmicrotubulepolymerizationpositiveregulationofmonocytedifferentiationpositiveregulationofmyeloidcelldifferentiationpositiveregulationofneuronprojectiondevelopmentproteinautophosphorylationregulationofcelladhesionregulationofcelldifferentiationregulationofcellmotilityregulationofcellpopulationproliferationregulationofcellshaperegulationofmastcelldegranulationregulationofvesicle-mediatedtransporttransmembranereceptorproteintyrosinekinasesignalingpathway
Insulin-like growth factor 2 mRNA-binding protein 1
4.3
82
68
IF2B1IF2B1Q9NZI8Q9NZI8CRD-mediatedmRNAstabilizationdendritearborizationmRNAtransportnegativeregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaynegativeregulationoftranslationnervoussystemdevelopmentneuronalstemcellpopulationmaintenancepalliumcellproliferationinforebrainpositiveregulationofcytoplasmictranslationregulationofcytokineproductionregulationofgeneexpressionregulationofmRNAstabilityinvolvedinresponsetostressregulationofRNAmetabolicprocess
Aldehyde dehydrogenase, dimeric NADP-preferring
4.3
71
71
AL3A1AL3A1P30838P30838cellularaldehydemetabolicprocesslipidmetabolicprocessxenobioticmetabolicprocess
Four and a half LIM domains protein 5
4.3
42
83
FHL5FHL5Q5TD97Q5TD97positiveregulationoftranscriptionbyRNApolymeraseII
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
4.3
89
54
A0A4X1VTL7A0A4X1VTL7A0A4X1VTL7A0A4X1VTL7
4-trimethylaminobutyraldehyde dehydrogenase
4.3
74
78
AL9A1AL9A1P49189P49189carnitinebiosyntheticprocesscellularaldehydemetabolicprocesshormonemetabolicprocessneurotransmitterbiosyntheticprocessproteinhomotetramerization
Tyrosine-protein kinase
4.3
50
74
Q3UKD6Q3UKD6Q3UKD6Q3UKD6
39S ribosomal protein L39, mitochondrial
4.3
82
67
RM39RM39Q9NYK5Q9NYK5mitochondrialtranslation
Mitogen-activated protein kinase kinase kinase 21
4.3
69
70
M3K21M3K21Q5TCX8Q5TCX8proteinautophosphorylationproteinphosphorylationsignaltransduction
General transcription and DNA repair factor IIH helicase subunit XPD
4.3
75
70
✔
ERCC2ERCC2P18074P18074agingapoptoticprocessbonemineralizationcentralnervoussystemmyelinformationchromosomesegregationembryoniccleavageerythrocytematurationextracellularmatrixorganizationhaircelldifferentiationhairfolliclematurationhematopoieticstemcelldifferentiationhematopoieticstemcellproliferationinuteroembryonicdevelopmentmaturationofSSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)multicellularorganismgrowthnucleotide-excisionrepairpositiveregulationofDNAbindingpositiveregulationofmitoticrecombinationpost-embryonicdevelopmentregulationofmitoticcellcyclephasetransitionresponsetooxidativestressspinalcorddevelopmenttranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseItranscription-couplednucleotide-excisionrepairUVprotection
H/ACA ribonucleoprotein complex subunit 2
4.3
67
75
NHP2NHP2Q9NX24Q9NX24cleavageinvolvedinrRNAprocessingmaturationofLSU-rRNApositiveregulationoftelomeraseRNAlocalizationtoCajalbodyrRNApseudouridinesynthesissnoRNAguidedrRNApseudouridinesynthesissnRNApseudouridinesynthesistelomeremaintenanceviatelomerase
Syntaxin-binding protein 1
4.3
73
69
STXB1STXB1P61765P61765axontargetrecognitioncellularresponsetotypeIIinterferondevelopmentalprocessinvolvedinreproductionestablishmentoflocalizationincellexocytosisintracellularproteintransportlong-termsynapticdepressionnegativeregulationofneuronapoptoticprocessnegativeregulationofprotein-containingcomplexassemblynegativeregulationofSNAREcomplexassemblynegativeregulationofsynaptictransmissionGABAergicneuromuscularsynaptictransmissionneuronapoptoticprocessneurotransmittersecretionplateletaggregationplateletdegranulationpositiveregulationofcalciumion-dependentexocytosispositiveregulationofexocytosispositiveregulationofglutamatesecretionneurotransmissionpositiveregulationofmastcelldegranulationpositiveregulationofvesicledockingpresynapticdensecorevesicleexocytosisproteinlocalizationtoplasmamembraneproteinstabilizationregulationofacrosomalvesicleexocytosisregulationofsynapticvesicleprimingregulationofvesiclefusionresponsetoestradiolSNAREcomplexassemblysynapticvesiclematurationsynapticvesicleprimingvesicledockinginvolvedinexocytosisvesicle-mediatedtransport
Prostaglandin-H2 D-isomerase
4.3
47
74
PTGDSPTGDSP41222P41222cyclooxygenasepathwaygeneexpressionmastcelldegranulationnegativeregulationofmalegermcellproliferationprostaglandinbiosyntheticprocessregulationofcircadiansleep/wakecyclesleepresponsetoglucocorticoid
GTPase IMAP family member 2
4.7
69
70
GIMA2GIMA2Q9UG22Q9UG22
Ribonuclease inhibitor
4.3
67
73
Q3SZN8Q3SZN8Q3SZN8Q3SZN8regulationofangiogenesis
RNA-binding protein 39
4.3
81
70
✔
RBM39RBM39Q14498Q14498mRNAprocessingregulationofmRNAsplicingviaspliceosomeRNAprocessingRNAsplicing
Mannose-1-phosphate guanyltransferase beta
4.3
83
64
GMPPBGMPPBQ9Y5P6Q9Y5P6GDP-mannosebiosyntheticprocessproteinglycosylation
Homeobox-containing protein 1
4.3
61
70
HMBX1HMBX1Q6NT76Q6NT76negativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofchromatinbindingpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenanceviatelomeraseregulationoftelomeraseactivity
Glutaminase kidney isoform, mitochondrial
4.3
102
60
✔
GLSKGLSKQ69ZX9Q69ZX9cellularglutamatehomeostasischemicalsynaptictransmissionglutamatebiosyntheticprocessglutaminecatabolicprocessproteinhomotetramerizationregulationofrespiratorygaseousexchangebynervoussystemprocesssucklingbehavior
Integrator complex subunit 7
4.3
71
70
INT7INT7Q9NVH2Q9NVH2cellularresponsetoionizingradiationDNAdamagecheckpointsignalingregulationoftranscriptionelongationbyRNApolymeraseII"snRNA3-endprocessing"snRNAprocessing
Actin alpha cardiac muscle 1
4.3
79
68
B6VNT8B6VNT8B6VNT8B6VNT8actinfilamentorganizationactin-myosinfilamentslidingheartcontractionmesenchymemigrationpositiveregulationofgeneexpression
G1/S-specific cyclin-D3
4.3
65
73
CCND3CCND3P30281P30281celldivisionG1/StransitionofmitoticcellcyclemitoticcellcyclephasetransitionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofG1/Stransitionofmitoticcellcyclepositiveregulationofproteinphosphorylationregulationofcellpopulationproliferationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofinsulinreceptorsignalingpathwaysignaltransductionTcellproliferation
Alpha-2A adrenergic receptor
1.8
50
89
ADA2AADA2AP08913P08913actincytoskeletonorganizationactivationofproteinkinaseactivityactivationofproteinkinaseBactivityacuteinflammatoryresponseadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingadrenergicreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadrenergicreceptorsignalingpathwaycellularresponsetohormonestimulusDNAreplicationfearresponsefemalepregnancyGprotein-coupledreceptorsignalingpathwayglucosehomeostasisintestinalabsorptionnegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofcalciumiontransportnegativeregulationofcalciumion-dependentexocytosisnegativeregulationofepinephrinesecretionnegativeregulationofinsulinsecretionnegativeregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusnegativeregulationoflipidcatabolicprocessnegativeregulationofnorepinephrinesecretionnegativeregulationofuterinesmoothmusclecontractionphospholipaseC-activatingadrenergicreceptorsignalingpathwayplateletactivationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofepidermalgrowthfactor-activatedreceptoractivitypositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofpotassiumiontransportpositiveregulationofwoundhealingpresynapticmodulationofchemicalsynaptictransmissionRasproteinsignaltransductionreceptortransactivationregulationofvasoconstrictionRhoproteinsignaltransductionthermoceptionvasodilation
Retinal dehydrogenase 2
4.3
99
61
AL1A2AL1A2O94788O947889-cis-retinoicacidbiosyntheticprocessbloodvesseldevelopmentcardiacmuscletissuedevelopmentcellpopulationproliferationcellularresponsetoretinoicaciddeterminationofbilateralsymmetryembryoniccamera-typeeyedevelopmentembryonicdigestivetractdevelopmentembryonicforelimbmorphogenesisfacedevelopmentheartmorphogenesishindbraindevelopmentkidneydevelopmentliverdevelopmentlungdevelopmentmidgutdevelopmentmorphogenesisofembryonicepitheliumnegativeregulationofcellpopulationproliferationneuralcrestcelldevelopmentneuraltubedevelopmentneurondifferentiationpancreasdevelopmentpituitaryglanddevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionproteinhomotetramerizationproximal/distalpatternformationregulationofvascularendothelialcellproliferationresponsetocytokineresponsetoestradiolresponsetovitaminAretinalmetabolicprocessretinoicacidbiosyntheticprocessretinoicacidmetabolicprocessretinoicacidreceptorsignalingpathwayinvolvedinsomitogenesisretinolmetabolicprocessuretermaturationvitaminAmetabolicprocess
Enoyl-CoA delta isomerase 1, mitochondrial
4.3
93
63
ECI1ECI1P42126P42126fattyacidbeta-oxidation
Transient receptor potential cation channel subfamily V member 1
4.3
49
73
TRPV1TRPV1O35433O35433behavioralresponsetopaincalciumionimportacrossplasmamembranecalciumiontransmembranetransportcalciumiontransportcellularresponsetoacidicpHcellularresponsetoalkaloidcellularresponsetoATPcellularresponsetocytokinestimuluscellularresponsetogrowthfactorstimuluscellularresponsetoheatcellularresponsetonervegrowthfactorstimuluscellularresponsetotemperaturestimuluscellularresponsetotumornecrosisfactordetectionofchemicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinthermoceptiondietinducedthermogenesisfevergenerationglutamatesecretioninflammatoryresponseiontransmembranetransportlipidmetabolicprocessmicroglialcellactivationnegativeregulationofestablishmentofblood-brainbarriernegativeregulationofheartratenegativeregulationofmitochondrialmembranepotentialnegativeregulationofsystemicarterialbloodpressurenegativeregulationoftranscriptionbyRNApolymeraseIIpeptidesecretionpositiveregulationofapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofgastricacidsecretionpositiveregulationofnitricoxidebiosyntheticprocessproteinhomotetramerizationresponsetocapsazepineresponsetoheatresponsetoorganonitrogencompoundresponsetopainresponsetopeptidehormoneresponsetopHsensoryperceptionofmechanicalstimulussensoryperceptionofpainsmoothmusclecontractioninvolvedinmicturitiontemperaturehomeostasisthermoceptionurinarybladdersmoothmusclecontraction
Egl nine homolog 1
2.0
78
81
✔
EGLN1HIF1AQ9GZT9Q16665cardiacmuscletissuemorphogenesiscellularironionhomeostasiscellularoxygenhomeostasiscellularresponsetohypoxiahearttrabeculaformationlabyrinthinelayerdevelopmentnegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivitypeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofmodificationofpostsynapticstructureregulationofneurondeathregulationproteincatabolicprocessatpostsynapseresponsetohypoxiaresponsetonitricoxideventricularseptummorphogenesisangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofDNA-templatedtranscriptionregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftransforminggrowthfactorbeta2productionresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
G protein-coupled receptor kinase 6
4.3
84
75
GRK6GRK6P43250P43250Gprotein-coupledreceptorsignalingpathwayproteinphosphorylationregulationofGprotein-coupledreceptorsignalingpathwayregulationofsignaltransductionWntsignalingpathway
DNA topoisomerase 1
4.3
81
64
✔
TOP1TOP1P11387P11387chromatinremodelingchromosomesegregationcircadianregulationofgeneexpressioncircadianrhythmDNAreplicationDNAtopologicalchangeembryoniccleavagepeptidyl-serinephosphorylationphosphorylationprogrammedcelldeathresponsetoxenobioticstimulus
Cyclin-dependent kinase 5 activator 1
4.3
77
68
CD5R1CD5R1Q15078Q15078axonguidanceaxonalfasciculationbraindevelopmentcerebellumdevelopmentembryodevelopmentendinginbirthoregghatchingephrinreceptorsignalingpathwayGprotein-coupledacetylcholinereceptorsignalingpathwayG1toG0transitioninvolvedincelldifferentiationhippocampusdevelopmentionotropicglutamatereceptorsignalingpathwaylayerformationincerebralcortexmicrotubulecytoskeletonorganizationnegativeregulationofDNA-templatedtranscriptionneuroncell-celladhesionneurondifferentiationneuronmigrationneuronprojectiondevelopmentpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmicrotubulepolymerizationpositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofsignalingreceptoractivityregulationofactincytoskeletonorganizationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofdendriticspinemorphogenesisregulationofmacroautophagyregulationofneurondifferentiationregulationofsynapticvesiclecyclerhythmicprocessserinephosphorylationofSTATproteinsuperiorolivarynucleusmaturation
Pantothenate kinase 1
4.3
62
77
PANK1PANK1Q8TE04Q8TE04coenzymeAbiosyntheticprocessphosphorylation
Fructose-bisphosphate aldolase A
4.3
84
72
ALDOAALDOAP04075P04075actinfilamentorganizationATPbiosyntheticprocessbindingofspermtozonapellucidafructose16-bisphosphatemetabolicprocessfructosemetabolicprocessglycolyticprocessmusclecellcellularhomeostasisproteinhomotetramerizationregulationofcellshapestriatedmusclecontraction
Non-homologous end-joining factor 1
4.3
55
74
NHEJ1NHEJ1Q9H9Q4Q9H9Q4BcelldifferentiationcentralnervoussystemdevelopmentDNAligationinvolvedinDNArepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)JrecombinationpositiveregulationofligaseactivityresponsetoionizingradiationTcelldifferentiation
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
4.3
82
65
✔
DUTDUTP33316P33316DNAreplicationdTMPbiosyntheticprocessdUMPbiosyntheticprocessdUTPcatabolicprocessliverdevelopmentnucleobase-containingcompoundmetabolicprocessregulationofprotein-containingcomplexassemblyresponsetoorganiccycliccompound
Ribonuclease inhibitor
4.9
57
69
RINIRINIP13489P13489mRNAcatabolicprocessregulationofangiogenesis
ATPase family AAA domain-containing protein 2
4.3
61
68
ATAD2ATAD2Q14CR1Q14CR1positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseII
Atypical kinase COQ8A, mitochondrial
4.3
88
64
COQ8ACOQ8AQ8NI60Q8NI60phosphorylationubiquinonebiosyntheticprocess
G1/S-specific cyclin-D1
4.3
63
75
CCND1CCND1P24385P24385celldivisioncellularresponsetoDNAdamagestimulusendoplasmicreticulumunfoldedproteinresponsefatcelldifferentiationG1/StransitionofmitoticcellcyclelactationLeydigcelldifferentiationliverregenerationmammaryglandalveolusdevelopmentmammaryglandepithelialcellproliferationmitoticcellcyclephasetransitionmitoticG1DNAdamagecheckpointsignalingnegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofproteinphosphorylationproteinphosphorylationre-entryintomitoticcellcycleregulationofcyclin-dependentproteinserine/threoninekinaseactivityresponsetocalciumionresponsetocorticosteroneresponsetoestradiolresponsetoestrogenresponsetoethanolresponsetoironionresponsetoleptinresponsetomagnesiumionresponsetoorganonitrogencompoundresponsetoUV-AresponsetovitaminEresponsetoX-rayresponsetoxenobioticstimulusWntsignalingpathway
Serine/threonine-protein kinase 40
4.3
74
78
STK40STK40Q8N2I9Q8N2I9glycogenmetabolicprocesslungalveolusdevelopmentlungmorphogenesismulticellularorganismgrowthnegativeregulationofapoptoticprocessproteinphosphorylationregulationofgeneexpressionregulationofMAPKcascaderespiratorysystemprocess
NHP2-like protein 1
4.3
85
66
NH2L1NH2L1P55769P55769boxC/DsnoRNPassemblymaturationofLSU-rRNAmaturationofSSU-rRNAmRNAsplicingviaspliceosomesinglefertilization
Cytochrome P450 2C9
4.3
81
63
CP2C9CP2C9P11712P11712amidemetabolicprocesscholesterolmetabolicprocessepoxygenaseP450pathwayestrogenmetabolicprocessicosanoidbiosyntheticprocesslong-chainfattyacidbiosyntheticprocessmonocarboxylicacidmetabolicprocessmonoterpenoidmetabolicprocessomega-hydroxylaseP450pathwayorganicacidmetabolicprocessoxidativedemethylationsteroidmetabolicprocessureametabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
Alpha-aminoadipic semialdehyde synthase, mitochondrial
4.3
106
61
AASSAASSQ9UDR5Q9UDR5L-lysinecatabolicprocesstoacetyl-CoAviasaccharopinelysinebiosyntheticprocessviaaminoadipicacidlysinecatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseII
Adenylate cyclase type 5
4.3
81
75
ADCY5ADCY5P30803P30803adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycAMPbiosyntheticprocesscellularresponsetoforskolinintracellularsignaltransductionpositiveregulationofcytosoliccalciumionconcentrationregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulus
Catenin alpha-1
4.3
52
77
CTNA1CTNA1P35221P35221agingapicaljunctionassemblyaxonregenerationcelladhesioncellmigrationcell-celladhesioncellularresponsetoindole-3-methanolepithelialcell-celladhesionestablishmentormaintenanceofcellpolarityextrinsicapoptoticsignalingpathwayinabsenceofligandgapjunctionassemblyintegrin-mediatedsignalingpathwaymalegonaddevelopmentnegativeregulationofcellmotilitynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofintegrin-mediatedsignalingpathwaynegativeregulationofneuroblastproliferationnegativeregulationofproteinlocalizationtonucleusneuroblastproliferationodontogenesisofdentin-containingtoothovarianfollicledevelopmentpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandpositiveregulationofsmoothenedsignalingpathwayproteinlocalizationresponsetoestrogensmoothenedsignalingpathway
Proteasome subunit alpha type-2
4.3
102
65
PSA2PSA2P25787P25787proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessresponsetovirus
Tyrosine-protein kinase Fgr
4.3
50
74
FGRFGRP09769P09769bonemineralizationcelldifferentiationdefenseresponsetoGram-positivebacteriumFc-gammareceptorsignalingpathwayinvolvedinphagocytosisimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinnateimmuneresponseintegrin-mediatedsignalingpathwaymyoblastproliferationnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofnaturalkillercellactivationpeptidyl-tyrosinephosphorylationpositiveregulationofcellmigrationpositiveregulationofcytokineproductionpositiveregulationofmastcelldegranulationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingproteinautophosphorylationproteinphosphorylationregulationofcellshaperegulationofinnateimmuneresponseregulationofphagocytosisregulationofproteinkinaseactivityresponsetovirusskeletalsystemmorphogenesistransmembranereceptorproteintyrosinekinasesignalingpathway
Serine--tRNA ligase, cytoplasmic
4.3
55
75
SYSCSYSCP49591P49591cytoplasmictranslationnegativeregulationofangiogenesisnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularendothelialgrowthfactorproductionselenocysteineincorporationselenocysteinyl-tRNA(Sec)biosyntheticprocessseryl-tRNAaminoacylationtranslation
Kinesin-like protein
4.3
96
61
Q6P164Q6P164Q6P164Q6P164microtubule-basedmovement
Aldehyde dehydrogenase family 1 member A3
4.4
81
65
✔
AL1A3AL1A3P47895P47895apoptoticprocessembryoniccamera-typeeyedevelopmentembryoniceyemorphogenesisfacedevelopmentHarderianglanddevelopmentinnerearmorphogenesislocomotorybehaviorneuromuscularprocesscontrollingbalancenucleusaccumbensdevelopmentolfactorypitdevelopmentopticcupmorphogenesisinvolvedincamera-typeeyedevelopmentpositiveregulationofapoptoticprocessproteinhomotetramerizationretinalmetabolicprocessretinoicacidbiosyntheticprocessretinoicacidmetabolicprocessretinolmetabolicprocessrightingreflex
Protein phosphatase 3 catalytic subunit alpha
2.0
nan
94
PP2BARCAN1Q08209P53805agingbraindevelopmentcalcineurin-mediatedsignalingcalcineurin-NFATsignalingcascadecalciumiontransportcardiacmusclehypertrophyinresponsetostresscellularresponsetoglucosestimulusdendritemorphogenesisdephosphorylationepidermisdevelopmentexcitatorypostsynapticpotentialG1/Stransitionofmitoticcellcyclekeratinocytedifferentiationmodulationofchemicalsynaptictransmissionmulticellularorganismalresponsetostressnegativeregulationofcalciumionimportacrossplasmamembranenegativeregulationofchromatinbindingnegativeregulationofdendritemorphogenesisnegativeregulationofgeneexpressionnegativeregulationofinsulinsecretionnegativeregulationofsignalingnegativeregulationofvoltage-gatedcalciumchannelactivitypeptidyl-serinedephosphorylationpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcardiacmusclehypertrophyinresponsetostresspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofconnectivetissuereplacementpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendocytosispositiveregulationofgeneexpressionpositiveregulationofglomerulusdevelopmentpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofsalivasecretionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvoltage-gatedcalciumchannelactivitypostsynapticmodulationofchemicalsynaptictransmissionproteindephosphorylationproteinimportintonucleusregulationofcellproliferationinvolvedinkidneymorphogenesisrenalfiltrationresponsetoamphetamineresponsetocalciumionskeletalmusclefiberdevelopmentskeletalmuscletissueregenerationTcellactivationtransitionbetweenfastandslowfiberwoundhealingcalcium-mediatedsignalinglocomotioninvolvedinlocomotorybehaviornegativeregulationofcalcineurin-NFATsignalingcascaderegulationofphosphoproteinphosphataseactivityresponsetoischemiaresponsetooxidativestressshort-termmemory
Protein farnesyltransferase subunit beta
4.0
72
76
FNTBRASKQ02293P01116cellpopulationproliferationfibroblastproliferationlipidmetabolicprocessnegativeregulationofcellpopulationproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinfarnesylationproteinprenylationregulationoffibroblastproliferationresponsetocytokineresponsetoinorganicsubstanceresponsetoorganiccycliccompoundwoundhealingactincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Geranylgeranyl transferase type-2 subunit alpha
3.4
64
75
PGTAPGTAQ08602Q08602proteingeranylgeranylation
Acylglycerol kinase, mitochondrial
4.3
69
77
AGKTIM29Q53H12Q9BSF4ceramidebiosyntheticprocessglycerolipidmetabolicprocessphosphorylationproteininsertionintomitochondrialinnermembranesphingolipidmetabolicprocess
Malate dehydrogenase, mitochondrial
4.3
75
70
MDHMMDHMP40926P40926aerobicrespirationgluconeogenesismalatemetabolicprocessNADHmetabolicprocessoxaloacetatemetabolicprocesstricarboxylicacidcycle
Mediator of RNA polymerase II transcription subunit 23
4.3
65
74
✔
MED23MED23Q9ULK4Q9ULK4positiveregulationofgeneexpressionpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptioninitiationatRNApolymeraseIIpromoter
Ras/Rap GTPase-activating protein SynGAP
4.3
69
71
SYGP1SYGP1Q9QUH6Q9QUH6axonogenesisdendritedevelopmentmaintenanceofpostsynapticspecializationstructuremodulationofchemicalsynaptictransmissionnegativeregulationofaxonogenesisnegativeregulationofneuronapoptoticprocessnegativeregulationofRasproteinsignaltransductionneuronapoptoticprocesspatternspecificationprocessRasproteinsignaltransductionreceptorclusteringregulationofGTPaseactivityregulationoflong-termneuronalsynapticplasticityregulationofMAPKcascaderegulationofsynapsestructureoractivityregulationofsynapticplasticityvisuallearning
ATPase family AAA domain-containing protein 2B
4.3
76
66
ATD2BATD2BQ9ULI0Q9ULI0positiveregulationoftranscriptionbyRNApolymeraseII
Polycomb protein EED
4.3
73
72
EEDEEDO75530O75530chromatinorganizationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIspinalcorddevelopment
D-2-hydroxyglutarate dehydrogenase, mitochondrial
4.3
79
67
D2HDHD2HDHQ8N465Q8N4652-oxoglutaratemetabolicprocessmalatemetabolicprocessproteinmetabolicprocessresponsetocobaltionresponsetomanganeseionresponsetozincion
DNA polymerase theta
4.3
73
69
DPOLQDPOLQO75417O75417base-excisionrepaircellularresponsetoDNAdamagestimulusDNArepairDNA-templatedDNAreplicationdouble-strandbreakrepairdouble-strandbreakrepairviaalternativenonhomologousendjoiningnegativeregulationofdouble-strandbreakrepairviahomologousrecombinationproteinhomooligomerizationsomatichypermutationofimmunoglobulingenes
Tyrosine-protein kinase SYK
4.3
51
75
KSYKKSYKP43405P43405adaptiveimmuneresponseangiogenesisanimalorganmorphogenesisBcelldifferentiationBcellreceptorsignalingpathwaybetaselectionbloodvesselmorphogenesiscalcium-mediatedsignalingcellactivationcelldifferentiationcellularresponsetolectincellularresponsetolipidcellularresponsetolow-densitylipoproteinparticlestimuluscellularresponsetomoleculeoffungalorigincollagen-activatedtyrosinekinasereceptorsignalingpathwaydefenseresponsetobacteriumFc-epsilonreceptorsignalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosisgamma-deltaTcelldifferentiationinnateimmuneresponseintegrin-mediatedsignalingpathwayinterleukin-3-mediatedsignalingpathwayintracellularsignaltransductionleukocyteactivationinvolvedinimmuneresponseleukocytecell-celladhesionleukotrienebiosyntheticprocesslymphvesseldevelopmentmacrophageactivationinvolvedinimmuneresponsemastcelldegranulationnegativeregulationofinflammatoryresponsetoantigenicstimulusneutrophilactivationinvolvedinimmuneresponseneutrophilchemotaxispeptidyl-serinephosphorylationpeptidyl-tyrosinephosphorylationplateletactivationpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofalpha-betaTcellproliferationpositiveregulationofBcelldifferentiationpositiveregulationofboneresorptionpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcold-inducedthermogenesispositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofgamma-deltaTcelldifferentiationpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-3productionpositiveregulationofinterleukin-4productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJUNkinaseactivitypositiveregulationofkillingofcellsofanotherorganismpositiveregulationofmastcellcytokineproductionpositiveregulationofmastcelldegranulationpositiveregulationofmonocytechemotacticprotein-1productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofreceptorinternalizationpositiveregulationofsuperoxideaniongenerationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferonproductionproteinautophosphorylationproteinimportintonucleusproteinphosphorylationreceptorinternalizationregulationofarachidonicacidsecretionregulationofDNA-bindingtranscriptionfactoractivityregulationofERK1andERK2cascaderegulationofneutrophildegranulationregulationofphagocytosisregulationofplateletactivationregulationofplateletaggregationregulationofsuperoxideaniongenerationregulationoftumornecrosisfactor-mediatedsignalingpathwayserotoninsecretionbyplateletstimulatoryC-typelectinreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathway
Protein argonaute-2
4.3
69
68
AGO2AGO2Q9UKV8Q9UKV8miRNAmetabolicprocessmiRNAprocessingmiRNA-mediatedgenesilencingbyinhibitionoftranslationmiRNA-mediatedgenesilencingbymRNAdestabilizationnegativeregulationofamyloidprecursorproteinbiosyntheticprocessnegativeregulationoftranslationalinitiationpositiveregulationofangiogenesispositiveregulationofgeneexpressionpositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftrophoblastcellmigrationpost-embryonicdevelopmentpre-miRNAprocessingRISCcomplexassemblyRNAsecondarystructureunwindingRNA-mediatedgenesilencingRNA-mediatedpost-transcriptionalgenesilencingsiRNAprocessingsiRNA-mediatedgenesilencingbymRNAdestabilizationtranslation
Cyclin-dependent kinase inhibitor 3
4.3
82
69
CDKN3CDKN3Q16667Q16667G1/Stransitionofmitoticcellcyclenegativeregulationofcellpopulationproliferationproteindephosphorylationregulationofcellcycleregulationofcyclin-dependentproteinserine/threoninekinaseactivity
ATP-dependent RNA helicase DDX25
4.3
81
72
DDX25DDX25Q9UHL0Q9UHL0mRNAexportfromnucleuspoly(A)+mRNAexportfromnucleusregulationoftranslationspermatiddevelopment
Mucin 16
4.3
77
66
Q9D1H1Q9D1H1Q9D1H1Q9D1H1negativeregulationofepithelialcellproliferationnegativeregulationofinterleukin-6productionnegativeregulationofwoundhealing
5'-AMP-activated protein kinase catalytic subunit alpha-1
4.3
41
75
AAPK1AAPK1P54645P54645autophagybileacidandbilesalttransportbileacidsignalingpathwayCAMKK-AMPKsignalingcascadecellularresponsetocalciumioncellularresponsetoethanolcellularresponsetoglucosestarvationcellularresponsetoglucosestimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetonutrientlevelscellularresponsetoorganonitrogencompoundcellularresponsetooxidativestresscellularresponsetoprostaglandinEstimuluscellularresponsetoxenobioticstimuluscholesterolbiosyntheticprocesschromatinorganizationcoldacclimationenergyhomeostasisfattyacidbiosyntheticprocessfattyacidhomeostasisfattyacidoxidationglucosehomeostasisglucosemetabolicprocessintracellularsignaltransductionlipidbiosyntheticprocesslipiddropletdisassemblymotorbehaviornegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationoflipidcatabolicprocessnegativeregulationofTORsignalingnegativeregulationoftranslationnegativeregulationoftubulindeacetylationneuroncellularhomeostasispositiveregulationofadiposetissuedevelopmentpositiveregulationofautophagypositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoffattyacidoxidationpositiveregulationofgeneexpressionpositiveregulationofgluconeogenesispositiveregulationofglucoseimportpositiveregulationofglycolyticprocesspositiveregulationofmitochondrialtranscriptionpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofskeletalmuscletissuedevelopmentproteinlocalizationtolipiddropletproteinphosphorylationregulationofbileacidsecretionregulationofcircadianrhythmregulationofgeneexpressionregulationofmicrotubulecytoskeletonorganizationregulationofpeptidyl-serinephosphorylationregulationofstressgranuleassemblyregulationofvesicle-mediatedtransportresponseto17alpha-ethynylestradiolresponsetoactivityresponsetocaffeineresponsetocamptothecinresponsetogammaradiationresponsetohydrogenperoxideresponsetoUVresponsetoxenobioticstimulusrhythmicprocessWntsignalingpathway
Chloride channel protein
4.3
61
70
E1B792E1B792E1B792E1B792chloridetransport
Protein arginine N-methyltransferase 5
4.3
60
74
ANM5ANM5O14744O14744chromatinorganizationcircadianregulationofgeneexpressionDNA-templatedtranscriptionterminationendothelialcellactivationGolgiribbonformationhistoneargininemethylationhistoneH4-R3methylationliverregenerationnegativeregulationofcelldifferentiationpeptidyl-argininemethylationpeptidyl-arginineN-methylationpositiveregulationofadenylatecyclase-inhibitingdopaminereceptorsignalingpathwaypositiveregulationofmRNAsplicingviaspliceosomepositiveregulationofoligodendrocytedifferentiationregulationofDNAmethylationregulationofDNA-templatedtranscriptionregulationofERK1andERK2cascaderegulationofmitoticnucleardivisionregulationofsignaltransductionbyp53classmediatorspliceosomalsnRNPassembly
5'(3')-deoxyribonucleotidase, cytosolic type
4.3
67
67
NT5CNT5CQ8TCD5Q8TCD5allantoinmetabolicprocessamidecatabolicprocessdCMPcatabolicprocessdephosphorylationdGMPcatabolicprocessdTMPcatabolicprocessdUMPcatabolicprocessIMPcatabolicprocesspyrimidinedeoxyribonucleotidecatabolicprocessUMPcatabolicprocess
SH3 domain-containing protein
4.3
87
67
Q8BX41Q8BX41Q8BX41Q8BX41
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
4.3
69
67
PP2BBPP2BBP16298P16298axonextensioncalcineurin-mediatedsignalingcalcineurin-NFATsignalingcascadecalcium-ionregulatedexocytosisdephosphorylationheartdevelopmentlearninglocomotioninvolvedinlocomotorybehaviorlymphangiogenesismemorynegativeregulationofcalciumionimportacrossplasmamembranenegativeregulationofsignalingnegativeregulationofTcellmediatedcytotoxicitynegativeregulationofvoltage-gatedcalciumchannelactivitypositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofDNA-templatedtranscriptionpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvoltage-gatedcalciumchannelactivityproteindephosphorylationproteinphosphorylationregulationofinsulinsecretionregulationofsynapticplasticityregulationofsynapticvesicleendocytosisresponsetocytokinesignaltransductionskeletalmusclefiberdevelopmentTcellactivationTcelldifferentiationTcellhomeostasisTcellmediatedcytotoxicityTcellproliferation
Hydroxymethylglutaryl-CoA lyase, mitochondrial
4.3
73
73
HMGCLHMGCLP35914P35914ketonebodybiosyntheticprocessleucinecatabolicprocesslipidmetabolicprocessmitochondrionorganization
Transforming protein RhoA
4.3
81
69
RHOARHOAP61586P61586actincytoskeletonorganizationactincytoskeletonreorganizationactinfilamentorganizationalpha-betaTcelllineagecommitmentandrogenreceptorsignalingpathwayangiotensin-mediatedvasoconstrictioninvolvedinregulationofsystemicarterialbloodpressureaorticvalveformationapicaljunctionassemblyapolipoproteinA-I-mediatedsignalingpathwaybetaselectioncelljunctionassemblycellmigrationcell-matrixadhesioncellularresponsetochemokinecellularresponsetocytokinestimuluscellularresponsetolipopolysaccharidecerebralcortexcellmigrationcleavagefurrowformationcorticalcytoskeletonorganizationcytoplasmicmicrotubuleorganizationendothelialcellmigrationendothelialtubelumenextensionestablishmentofepithelialcellapical/basalpolarityestablishmentormaintenanceofcellpolarityforebrainradialglialcelldifferentiationGTPmetabolicprocesskidneydevelopmentmitoticcleavagefurrowformationmitoticspindleassemblymotorneuronapoptoticprocessnegativechemotaxisnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellsizenegativeregulationofcell-substrateadhesionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofintracellularsteroidhormonereceptorsignalingpathwaynegativeregulationofmotorneuronapoptoticprocessnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoxidativephosphorylationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronmigrationneuronprojectionmorphogenesisodontogenesisossificationinvolvedinbonematurationpositiveregulationofactinfilamentpolymerizationpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytokinesispositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationoflipaseactivitypositiveregulationofneuronapoptoticprocesspositiveregulationofneurondifferentiationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpodosomeassemblypositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofstressfiberassemblypositiveregulationofTcellmigrationpositiveregulationoftranslationpositiveregulationofvascularassociatedsmoothmusclecontractionregulationofactincytoskeletonorganizationregulationofcalciumiontransportregulationofcellmigrationregulationofcellshaperegulationofdendritedevelopmentregulationoffocaladhesionassemblyregulationofmicrotubulecytoskeletonorganizationregulationofmodificationofpostsynapticactincytoskeletonregulationofmodificationofpostsynapticstructureregulationofneuralprecursorcellproliferationregulationofosteoblastproliferationregulationofsystemicarterialbloodpressurebyendothelinregulationoftranscriptionbyRNApolymeraseIIresponsetoaminoacidresponsetoethanolresponsetoglucocorticoidresponsetoglucoseresponsetohypoxiaresponsetomechanicalstimulusresponsetoxenobioticstimulusRhoproteinsignaltransductionRoundaboutsignalingpathwayskeletalmusclesatellitecellmigrationskeletalmuscletissuedevelopmentstressfiberassemblystress-activatedproteinkinasesignalingcascadesubstantianigradevelopmentsubstrateadhesion-dependentcellspreadingtrabeculamorphogenesisWntsignalingpathwayplanarcellpolaritypathwaywoundhealingspreadingofcells
Disks large homolog 4
4.3
78
68
DLG4DLG4P31016P31016AMPAglutamatereceptorclusteringcell-celladhesioncellularresponsetopotassiumioncerebralcortexdevelopmentchemicalsynaptictransmissiondendriticspinemorphogenesisdendriticspineorganizationestablishmentofproteinlocalizationlocomotoryexplorationbehaviornegativeregulationofreceptorinternalizationneuromuscularprocesscontrollingbalanceneuronalionchannelclusteringneurotransmitterreceptorlocalizationtopostsynapticspecializationmembranepositiveregulationofAMPAglutamatereceptorclusteringpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendritemorphogenesispositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofneuronprojectionarborizationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofsynaptictransmissionpostsynapticneurotransmitterreceptordiffusiontrappingproteinlocalizationtosynapseprotein-containingcomplexassemblyreceptorclusteringreceptorlocalizationtosynapseregulationofgroomingbehaviorregulationoflong-termneuronalsynapticplasticityregulationofneuronalsynapticplasticityregulationofNMDAreceptoractivitysocialbehaviorsynapticvesiclematurationvocalizationbehavior
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
4.3
86
63
✔
OGT1OGT1O15294O15294apoptoticprocesschromatinorganizationcircadianregulationofgeneexpressionhemopoiesishistoneH4-K16acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationmitophagynegativeregulationofcellmigrationnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayphosphatidylinositol-mediatedsignalingpositiveregulationofcold-inducedthermogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationofhistoneH3-K27methylationpositiveregulationofhistoneH3-K4methylationpositiveregulationofproteolysispositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIproteinO-linkedglycosylationproteinprocessingregulationofdosagecompensationbyinactivationofXchromosomeregulationofgluconeogenesisregulationofglycolyticprocessregulationofinsulinreceptorsignalingpathwayregulationofnecroptoticprocessregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofRacproteinsignaltransductionregulationofsynapseassemblyregulationoftranscriptionbyRNApolymeraseIIresponsetoinsulinresponsetonutrientsignaltransduction
Nuclear transcription factor Y subunit beta
4.3
76
68
NFYBNFYBP25208P25208cellularresponsetoleukemiainhibitoryfactorhistoneH3-K4trimethylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationofhistoneacetylationregulationoftranscriptionbyRNApolymeraseII
Proto-oncogene tyrosine-protein kinase Src
4.3
57
69
SRCSRCP12931P12931activationofproteinkinaseBactivityadherensjunctionorganizationangiotensin-activatedsignalingpathwayinvolvedinheartprocessboneresorptionbranchinginvolvedinmammaryglandductmorphogenesiscelladhesioncellcyclecelldifferentiationcell-celladhesioncellularresponsetofattyacidcellularresponsetofluidshearstresscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetoinsulinstimuluscellularresponsetolipopolysaccharidecellularresponsetopeptidehormonestimuluscellularresponsetoplatelet-derivedgrowthfactorstimuluscellularresponsetoprogesteronestimuluscellularresponsetoprolactinDNAbiosyntheticprocessentryofbacteriumintohostcellephrinreceptorsignalingpathwayepidermalgrowthfactorreceptorsignalingpathwayERBB2signalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosisfocaladhesionassemblyforebraindevelopmentinnateimmuneresponseintegrin-mediatedsignalingpathwayinterleukin-6-mediatedsignalingpathwayintestinalepithelialcelldevelopmentintracellularsignaltransductionlearningormemoryleukocytemigrationmacroautophagymyoblastproliferationnegativeregulationofanoikisnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoffocaladhesionassemblynegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofintrinsicapoptoticsignalingpathwaynegativeregulationofmitochondrialdepolarizationnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomeraseneurotrophinTRKreceptorsignalingpathwayodontogenesisoogenesisosteoclastdevelopmentpeptidyl-serinephosphorylationpeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplateletactivationpositiveregulationofapoptoticprocesspositiveregulationofboneresorptionpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofcytokineproductionpositiveregulationofdephosphorylationpositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofglucosemetabolicprocesspositiveregulationofhipposignalingpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofintegrinactivationpositiveregulationoflamellipodiummorphogenesispositiveregulationofmalegermcellproliferationpositiveregulationofMAPkinaseactivitypositiveregulationofnon-membranespanningproteintyrosinekinaseactivitypositiveregulationofNotchsignalingpathwaypositiveregulationofovarianfollicledevelopmentpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofpodosomeassemblypositiveregulationofproteinautophosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinprocessingpositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofproteintransportpositiveregulationofRasproteinsignaltransductionpositiveregulationofsmallGTPasemediatedsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationprimaryovarianfolliclegrowthprogesteronereceptorsignalingpathwayproteinautophosphorylationproteindestabilizationregulationofboneresorptionregulationofcaveolin-mediatedendocytosisregulationofcellprojectionassemblyregulationofcell-celladhesionregulationofearlyendosometolateendosometransportregulationofepithelialcellmigrationregulationofintracellularestrogenreceptorsignalingpathwayregulationofpostsynapticneurotransmitterreceptoractivityregulationofproteinbindingregulationofvascularpermeabilityresponsetoacidicpHresponsetoelectricalstimulusresponsetointerleukin-1responsetomechanicalstimulusresponsetomineralocorticoidresponsetonutrientlevelsresponsetovirusresponsetoxenobioticstimulussignalcomplexassemblysignaltransductionskeletalmusclecellproliferationspermatogenesisstimulatoryC-typelectinreceptorsignalingpathwaystressfiberassemblysubstrateadhesion-dependentcellspreadingTcellcostimulationtranscytosistransforminggrowthfactorbetareceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathwayuterusdevelopmentvascularendothelialgrowthfactorreceptorsignalingpathway
C-terminal-binding protein 2
4.3
81
74
CTBP2CTBP2P56545P56545cellularresponsetoleukemiainhibitoryfactornegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofchromatinbindingpositiveregulationofretinoicacidreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIsynapticvesicledockingviralgenomereplicationwhitefatcelldifferentiation
Fructose-bisphosphate aldolase B
4.3
85
69
ALDOBALDOBP05062P05062fructose16-bisphosphatemetabolicprocessfructosecatabolicprocesstohydroxyacetonephosphateandglyceraldehyde-3-phosphatefructosemetabolicprocessglycolyticprocessNADHoxidationpositiveregulationofATP-dependentactivityvacuolarproton-transportingV-typeATPasecomplexassembly
Sepiapterin reductase
4.3
76
64
✔
SPRESPREP35270P35270nitricoxidebiosyntheticprocesstetrahydrobiopterinbiosyntheticprocess
Crossover junction endonuclease EME1
4.3
74
72
EME1EME1Q96AY2Q96AY2double-strandbreakrepairmitoticintra-SDNAdamagecheckpointsignalingreplicationforkprocessingresolutionofmeioticrecombinationintermediatesresponsetointra-SDNAdamagecheckpointsignaling
Phosphatidylinositol 3-kinase catalytic subunit type 3
4.3
81
65
PK3C3PK3C3Q8NEB9Q8NEB9autophagosomeassemblyautophagosomematurationautophagyautophagyofperoxisomecellcyclecelldivisioncellularresponsetoglucosestarvationearlyendosometolateendosometransportendocytosisendosomeorganizationmacroautophagyphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingpositiveregulationbyhostofviralgenomereplicationproteinlipidationproteinlocalizationtophagophoreassemblysiteproteinphosphorylationproteinprocessingproteintargetingtolysosomeregulationofautophagyregulationofcytokinesisregulationofmacroautophagyregulationofproteinsecretionresponsetoleucine
Cyclic nucleotide-gated cation channel alpha-3
4.3
72
67
CNGA3CNGA3Q16281Q16281cationtransmembranetransportcationtransportinorganiccationimportacrossplasmamembraneresponsetocAMPresponsetocorticosteroidresponsetomagnesiumionsignaltransductionvisualperception
Bifunctional epoxide hydrolase 2
4.3
95
60
HYESHYESP34913P34913cholesterolhomeostasisdephosphorylationepoxidemetabolicprocessphospholipiddephosphorylationpositiveregulationofgeneexpressionregulationofcholesterolmetabolicprocessresponsetotoxicsubstancestilbenecatabolicprocess
RRP12-like protein
4.3
74
67
✔
RRP12RRP12Q5JTH9Q5JTH9rRNAprocessing
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
4.3
90
69
ACADMACADMP11310P11310cardiacmusclecelldifferentiationcarnitinebiosyntheticprocesscarnitinemetabolicprocessCoA-linkedfattyacidbeta-oxidationfattyacidbeta-oxidationusingacyl-CoAdehydrogenaseglycogenbiosyntheticprocessliverdevelopmentmedium-chainfattyacidcatabolicprocessmedium-chainfattyacidmetabolicprocesspost-embryonicdevelopmentregulationofgluconeogenesisresponsetocoldresponsetostarvation
Tuberin
4.3
69
78
TSC2TSC2P49815P49815anoikisendocytosisheartdevelopmentinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofmitophagynegativeregulationofphosphatidylinositol3-kinasesignalingnegativeregulationofproteinkinaseactivitynegativeregulationofproteinkinaseBsignalingnegativeregulationofTORsignalingnegativeregulationofWntsignalingpathwayneuraltubeclosurepositivechemotaxispositiveregulationofGTPaseactivitypositiveregulationofmacroautophagyproteinimportintonucleusproteinkinaseBsignalingproteinlocalizationregulationofcellcycleregulationofendocytosisregulationofinsulinreceptorsignalingpathwayregulationofsmallGTPasemediatedsignaltransductionvesicle-mediatedtransport
MOB kinase activator 1B
4.4
59
80
MOB1BMOB1BQ8BPB0Q8BPB0hipposignalingpositiveregulationofproteinphosphorylationregulationofproteinautophosphorylationsignaltransduction
Alanine--glyoxylate aminotransferase
4.4
73
69
AGT1AGT1P21549P21549glycinebiosyntheticprocessbytransaminationofglyoxylateglyoxylatecatabolicprocessglyoxylatemetabolicprocessL-alaninecatabolicprocessL-cysteinecatabolicprocessL-serinemetabolicprocessNotchsignalingpathwayoxalicacidsecretion
ATP synthase subunit s, mitochondrial
4.8
68
71
ATP5SATP5SP22027P22027ATPbiosyntheticprocessprotontransmembranetransport
Protein-arginine deiminase type-4
5.3
nan
77
PADI4PADI4Q9UM07Q9UM07chromatinorganizationchromatinremodelinginnateimmuneresponsenucleosomeassemblypost-translationalproteinmodificationproteinmodificationprocessstemcellpopulationmaintenance
ATP-dependent RNA helicase DDX3X
4.4
74
69
✔
DDX3XDDX3XO00571O00571celldifferentiationcellularresponsetoarsenic-containingsubstancecellularresponsetoosmoticstresscellularresponsetoviruschromosomesegregationcytosolicribosomeassemblyextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsgametegenerationinnateimmuneresponseintracellularsignaltransductionintrinsicapoptoticsignalingpathwaylipidhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofcellgrowthnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofintrinsicapoptoticsignalingpathwaynegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftranslationpositiveregulationofapoptoticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofG1/Stransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofproteinacetylationpositiveregulationofproteinautophosphorylationpositiveregulationofproteinK63-linkedubiquitinationpositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationoftoll-likereceptor7signalingpathwaypositiveregulationoftoll-likereceptor8signalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationpositiveregulationoftranslationinresponsetoendoplasmicreticulumstresspositiveregulationoftranslationalinitiationpositiveregulationofviralgenomereplicationprimarymiRNAprocessingproteinlocalizationtocytoplasmicstressgranuleresponsetovirusRNAsecondarystructureunwindingstressgranuleassemblytranslationalinitiationWntsignalingpathway
C-terminal-binding protein 1
4.4
78
75
CTBP1CTBP1Q13363Q13363heterochromatinformationnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofhistoneacetylationnegativeregulationofhistoneH4acetylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofhistonedeacetylationproteinphosphorylationregulationofcellcycleregulationoftranscriptionbyRNApolymeraseIIsynapticvesicleclusteringsynapticvesicleendocytosisviralgenomereplicationwhitefatcelldifferentiation
Nucleotide binding oligomerization domain containing 2
4.0
nan
79
G1T469G1T469G1T469G1T469biosyntheticprocessofantibacterialpeptidesactiveagainstGram-positivebacteriacellularresponsetolipopolysaccharidecellularresponsetomuramyldipeptidecellularresponsetopeptidoglycandetectionofbacteriumdetectionofmuramyldipeptideERK1andERK2cascadeestablishmentoflocalizationincellI-kappaBkinase/NF-kappaBsignalinginnateimmuneresponseinmucosaJNKcascademaintenanceofgastrointestinalepitheliumnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-18productionnegativeregulationofinterleukin-2productionnegativeregulationofmacrophageapoptoticprocessnegativeregulationofmacrophagecytokineproductionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofTcellmediatedimmunitynegativeregulationoftoll-likereceptor2signalingpathwaynegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionNIK/NF-kappaBsignalingnucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypeptidyl-tyrosinephosphorylationphagocytosispositiveregulationofBcellactivationpositiveregulationofbiosyntheticprocessofantibacterialpeptidesactiveagainstGram-positivebacteriapositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofdendriticcellantigenprocessingandpresentationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-17productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofMAPkinaseactivitypositiveregulationofmonocytechemotacticprotein-1productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphagocytosispositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofprostaglandin-Esynthaseactivitypositiveregulationofprostaglandin-endoperoxidesynthaseactivitypositiveregulationofproteinK63-linkedubiquitinationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftype2immuneresponsepositiveregulationofxenophagyregulationofneutrophilchemotaxisresponsetoexogenousdsRNAtoll-likereceptor2signalingpathwayxenophagy
Uridine phosphorylase
4.4
61
69
A5PJH9A5PJH9A5PJH9A5PJH9nucleosidecatabolicprocessnucleotidecatabolicprocessUMPsalvage
Lysine-specific histone demethylase 1A
4.4
65
74
KDM1AKDM1AO60341O60341alternativemRNAsplicingviaspliceosomecellularresponsetocAMPcellularresponsetogammaradiationcellularresponsetoUVcerebralcortexdevelopmentDNArepair-dependentchromatinremodelingguaninemetabolicprocesshistoneH3-K4demethylationmusclecelldevelopmentnegativeregulationofDNAbindingnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofhistoneH3-K4methylationnegativeregulationofhistoneH3-K9methylationnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofproteinbindingnegativeregulationoftranscriptionbyRNApolymeraseIIneuronmaturationpositiveregulationofcellsizepositiveregulationofchromatinbindingpositiveregulationofcold-inducedthermogenesispositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofneuralprecursorcellproliferationpositiveregulationofneuroblastproliferationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofproteinubiquitinationpositiveregulationofstemcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIproteindemethylationregulationofandrogenreceptorsignalingpathwayregulationofDNAmethylation-dependentheterochromatinformationregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofproteinlocalizationregulationoftranscriptionbyRNApolymeraseIIresponsetofungicide
Methylthioribulose-1-phosphate dehydratase
4.4
80
75
✔
MTNBMTNBQ96GX9Q96GX9apoptoticprocessL-methioninesalvagefrommethylthioadenosineL-methioninesalvagefromS-adenosylmethioninenegativeregulationofapoptoticprocessproteinhomotetramerizationpyroptosisregulationofERK1andERK2cascade
Heat shock cognate 71 kDa protein
4.4
65
76
HSP7CHSP7CP11142P11142ATPmetabolicprocesscellularresponsetostarvationcellularresponsetosteroidhormonestimuluscellularresponsetounfoldedproteinchaperonecofactor-dependentproteinrefoldingchaperone-mediatedautophagychaperone-mediatedautophagytranslocationcomplexdisassemblylateendosomalmicroautophagymembraneorganizationmRNAsplicingviaspliceosomenegativeregulationofDNA-templatedtranscriptionnegativeregulationofsupramolecularfiberorganizationpositiveregulationbyhostofviralgenomereplicationpositiveregulationofmRNAsplicingviaspliceosomeproteinfoldingproteinrefoldingproteintargetingtolysosomeinvolvedinchaperone-mediatedautophagyregulationofcellcycleregulationofpostsynapseorganizationregulationofproteincomplexstabilityregulationofproteinimportregulationofproteinstabilityregulationofprotein-containingcomplexassemblyresponsetounfoldedproteinslowaxonaltransportvesicle-mediatedtransport
Nuclear factor NF-kappa-B p105 subunit
2.0
61
88
✔
THIONFKB1P10599P19838activationofproteinkinaseBactivitycellredoxhomeostasisnegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNAbindingpositiveregulationofpeptidyl-cysteineS-nitrosylationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinkinaseBsignalingresponsetonitricoxideresponsetoradiationapoptoticprocessBcellreceptorsignalingpathwaycellularresponsetoangiotensincellularresponsetodsRNAcellularresponsetointerleukin-1cellularresponsetointerleukin-17cellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetonicotinecellularresponsetotumornecrosisfactorcellularresponsetovirusinflammatoryresponseJNKcascademammaryglandinvolutionnegativeregulationofapoptoticprocessnegativeregulationofcalcidiol1-monooxygenaseactivitynegativeregulationofcholesteroltransportnegativeregulationofgeneexpressionnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-12productionnegativeregulationofproteinmetabolicprocessnegativeregulationofvitaminDbiosyntheticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofhyaluronanbiosyntheticprocesspositiveregulationoflipidstoragepositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofmiRNAmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetomusclestretchtranscriptionbyRNApolymeraseII
E3 ubiquitin-protein ligase RNF135
4.4
70
71
RN135RN135Q8IUD6Q8IUD6antiviralinnateimmuneresponsefreeubiquitinchainpolymerizationinnateimmuneresponsepositiveregulationofinterferon-betaproductionproteinhomooligomerizationproteinK63-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofinnateimmuneresponseRIG-Isignalingpathway
Isopentenyl-diphosphate Delta-isomerase 1
4.4
73
70
IDI1IDI1Q13907Q13907cholesterolbiosyntheticprocessdimethylallyldiphosphatebiosyntheticprocessisopentenyldiphosphatebiosyntheticprocessisoprenoidbiosyntheticprocess
D(1A) dopamine receptor
2.0
55
86
DRD1DRD1P21728P21728activationofadenylatecyclaseactivityadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-activatingdopaminereceptorsignalingpathwayadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadultwalkingbehaviorastrocytedevelopmentbehavioralfearresponsebehavioralresponsetococainecellularresponsetocatecholaminestimuluscellularresponsetodopaminecerebralcortexGABAergicinterneuronmigrationconditionedtasteaversiondentategyrusdevelopmentdopaminemetabolicprocessdopaminereceptorsignalingpathwaydopaminetransportGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerglucoseimportgroomingbehaviorhabituationlong-termsynapticdepressionlong-termsynapticpotentiationmaternalbehaviormatingbehaviormemorymodificationofpostsynapticstructureneuronalactionpotentialoperantconditioningperistalsisphospholipaseC-activatingdopaminereceptorsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofneuronmigrationpositiveregulationofpotassiumiontransportpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsynaptictransmissionglutamatergicprepulseinhibitionpresynapticmodulationofchemicalsynaptictransmissionproteinimportintonucleusproteinphosphorylationregulationofdopaminemetabolicprocessregulationofdopamineuptakeinvolvedinsynaptictransmissionregulationofproteinphosphorylationresponsetoamphetamineresponsetoxenobioticstimulussensitizationstriatumdevelopmentsynapseassemblysynaptictransmissionglutamatergictemperaturehomeostasistransmissionofnerveimpulsevasodilationvisuallearning
BTB/POZ domain-containing protein KCTD1
4.4
71
70
KCTD1KCTD1Q719H9Q719H9negativeregulationofDNA-templatedtranscriptionproteinhomooligomerization
Pleckstrin homology domain-containing family M member 2
4.4
81
65
✔
PKHM2PKHM2Q8IWE5Q8IWE5Golgiorganizationlysosomelocalizationnaturalkillercellmediatedcytotoxicitypositiveregulationofmembranetubulationregulationofproteinlocalization
Cobalamin trafficking protein CblD
4.4
24
80
MMADMMADQ9H3L0Q9H3L0cobalaminmetabolicprocess
IQ motif and SEC7 domain-containing protein 1
4.4
59
67
IQEC1IQEC1Q6DN90Q6DN90actincytoskeletonorganizationdendriticspinedevelopmentpositiveregulationoffocaladhesiondisassemblypositiveregulationofkeratinocytemigrationregulationofARFproteinsignaltransduction
F-box/LRR-repeat protein 2
4.4
83
70
FBXL2FBXL2Q9UKC9Q9UKC9modulationbyhostofviralRNAgenomereplicationnegativeregulationofNLRP3inflammasomecomplexassemblyproteinmodificationprocessproteinmonoubiquitinationproteinubiquitinationproteolysisregulationofautophagyregulationofinflammatoryresponseregulationofphosphatidylinositol3-kinasesignalingSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Placental protein 13-like
4.4
56
67
PPL13PPL13Q8TCE9Q8TCE9apoptoticprocess
40S ribosomal protein S11
4.4
71
72
✔
RS11RS11P62280P62280cytoplasmictranslationtranslation
Rho GTPase-activating protein 21
4.4
53
75
RHG21RHG21Q8NI19Q8NI19establishmentofGolgilocalizationGolgilocalizationGolgiorganizationmaintenanceofGolgilocationorganelletransportalongmicrotubuleregulationofsmallGTPasemediatedsignaltransductionsignaltransduction
Adiponectin receptor protein 2
3.4
35
84
PAQR2PAQR2Q86V24Q86V24adiponectin-activatedsignalingpathwayfattyacidoxidationglucosehomeostasishormone-mediatedsignalingpathwaypositiveregulationofcold-inducedthermogenesisvascularwoundhealing
Galactoside-binding soluble lectin 13
5.3
44
67
PP13PP13Q9UHV8Q9UHV8apoptoticprocessphospholipidmetabolicprocess
Dihydropyrimidinase-related protein 5
4.4
69
76
DPYL5DPYL5Q9BPU6Q9BPU6axonguidancenegativeregulationofdendritemorphogenesisnervoussystemdevelopmentsignaltransduction
Tyrosine-protein phosphatase non-receptor type 18
4.4
76
68
PTN18PTN18Q99952Q99952blastocystformationnegativeregulationofERBBsignalingpathwaypeptidyl-tyrosinedephosphorylationproteindephosphorylation
ATP-dependent RNA helicase SUPV3L1, mitochondrial
4.4
89
68
SUV3SUV3Q8IYB8Q8IYB8DNAduplexunwindingDNArecombinationmitochondrialmRNAcatabolicprocessmitochondrialmRNAsurveillancemitochondrialncRNAsurveillance"mitochondrialRNA3-endprocessing"mitochondrialRNAsurveillancemitochondrionmorphogenesisnegativeregulationofapoptoticprocesspositiveregulationofcellgrowthpositiveregulationofmitochondrialRNAcatabolicprocessRNAcatabolicprocess
Protein-arginine deiminase type-3
5.7
nan
71
PADI3PADI3Q9ULW8Q9ULW8
Mitotic spindle assembly checkpoint protein MAD2A
4.4
62
70
MD2L1MD2L1Q13257Q13257celldivisionestablishmentofcentrosomelocalizationestablishmentofmitoticspindleorientationmitoticsisterchromatidsegregationmitoticspindleassemblycheckpointsignalingnegativeregulationofapoptoticprocessnegativeregulationofmitoticcellcyclenegativeregulationofproteincatabolicprocessnegativeregulationofubiquitinproteinligaseactivitynegativeregulationofubiquitin-proteintransferaseactivitypositiveregulationofmitoticcellcyclespindleassemblycheckpoint
Serine/threonine-protein kinase WNK1
4.4
84
63
WNK1WNK1Q9JIH7Q9JIH7cationhomeostasiscellularchlorideionhomeostasiscellularresponsetocalciumioncellularresponsetochemokinechemokine(C-Cmotif)ligand21signalingpathwayintracellularsignaltransductionionhomeostasisiontransportlymphocytemigrationintolymphnodemodulationofchemicalsynaptictransmissionnegativeregulationofcell-celladhesionmediatedbyintegrinnegativeregulationofGTPaseactivitynegativeregulationofheterotypiccell-celladhesionnegativeregulationofkinaseactivitynegativeregulationofleukocytecell-celladhesionnegativeregulationofpancreaticjuicesecretionnegativeregulationofsodiumiontransportpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofpotassiumionimportacrossplasmamembranepositiveregulationofsodiumiontransmembranetransporteractivitypositiveregulationofsystemicarterialbloodpressurepositiveregulationofTcellchemotaxispotassiumionhomeostasisproteinautophosphorylationproteinphosphorylationregulationofbloodpressureregulationofcationtransmembranetransportregulationofsodiumiontransmembranetransportregulationofsodiumiontransportsignaltransductionsodiumiontransmembranetransportTcellreceptorsignalingpathway
Myosin-binding protein C, slow-type
4.4
67
71
MYPC1MYPC1Q00872Q00872celladhesion
Rho-related GTP-binding protein RhoD
4.5
84
71
RHODRHODO00212O00212actinfilamentbundleassemblyactinfilamentorganizationcellmigrationcorticalcytoskeletonorganizationestablishmentormaintenanceofcellpolarityfocaladhesionassemblylamellipodiumassemblypositiveregulationofcelladhesionpositiveregulationofcellmigrationregulationofactincytoskeletonorganizationregulationofcellshaperegulationofsmallGTPasemediatedsignaltransductionRhoproteinsignaltransduction
Dual specificity protein phosphatase 16
4.4
68
75
DUS16DUS16Q9BY84Q9BY84dephosphorylationMAPKexportfromnucleusnegativeregulationofJUNkinaseactivitynegativeregulationofMAPKcascadeproteindephosphorylation
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
4.7
73
65
PP1GPP1GP63088P63088cellcyclecelldivisioncircadianregulationofgeneexpressionentrainmentofcircadianclockbyphotoperiodglycogenmetabolicprocessneurondifferentiationpositiveregulationofglialcellproliferationproteindephosphorylationregulationofcircadianrhythmregulationofnucleocytoplasmictransport
StAR-related lipid transfer protein 3
4.4
61
74
STAR3STAR3Q14849Q14849cholesterolmetabolicprocesscholesteroltransportlipidmetabolicprocessmitochondrialtransportprogesteronebiosyntheticprocesssteroidmetabolicprocessvesicletetheringtoendoplasmicreticulum
Glutathione S-transferase Mu 4
4.4
69
69
GSTM4GSTM4Q03013Q03013glutathionemetabolicprocesslong-chainfattyacidbiosyntheticprocessnitrobenzenemetabolicprocessxenobioticcatabolicprocess
Cyclin-dependent kinase-like 1
4.4
70
70
CDKL1CDKL1Q00532Q00532proteinphosphorylationregulationofciliumassembly
Ethanolamine-phosphate phospho-lyase
4.4
88
65
AT2L1AT2L1Q8TBG4Q8TBG4
Cytochrome P450 2C8
4.4
83
62
CP2C8CP2C8P10632P10632epoxygenaseP450pathwayestrogenmetabolicprocessicosanoidbiosyntheticprocesslipidhydroxylationlong-chainfattyacidbiosyntheticprocessomega-hydroxylaseP450pathwayorganicacidmetabolicprocessoxidativedemethylationretinoicacidmetabolicprocessretinolmetabolicprocesssteroidmetabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
Desmoglein-3
4.4
65
73
DSG3DSG3P32926P32926cell-celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
S-formylglutathione hydrolase
4.4
47
70
ESTDESTDP10768P10768formaldehydecatabolicprocess
Ribonucleoside-diphosphate reductase subunit M2 B
4.4
73
67
RIR2BRIR2BQ7LG56Q7LG56"2-deoxyribonucleotidebiosyntheticprocess"deoxyribonucleosidetriphosphatemetabolicprocessdeoxyribonucleotidebiosyntheticprocessDNArepairDNAsynthesisinvolvedinDNArepairkidneydevelopmentmitochondrialDNAreplicationnegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofG0toG1transitionpositiveregulationofG2/Mtransitionofmitoticcellcyclerenalsystemprocessresponsetoamineresponsetooxidativestressribonucleosidediphosphatemetabolicprocess
Phenylalanine-4-hydroxylase
4.4
77
65
PH4HPH4HP00439P00439aminoacidbiosyntheticprocesscatecholaminebiosyntheticprocessL-phenylalaninecatabolicprocessneurotransmitterbiosyntheticprocesstyrosinebiosyntheticprocess
Isoform 2 of WD repeat domain phosphoinositide-interacting protein 2
4.4
85
69
WIPI2WIPI2Q9Y4P8-2Q9Y4P8-2
Tryptophan 5-hydroxylase 2
4.4
76
66
TPH2TPH2Q8IWU9Q8IWU9aromaticaminoacidmetabolicprocesscellularresponsetolithiumioncircadianrhythmresponsetoactivityresponsetocalciumionresponsetoestrogenresponsetoglucocorticoidresponsetonutrientlevelsserotoninbiosyntheticprocess
Protein spire homolog 1
4.4
92
62
SPIR1SPIR1Q08AE8Q08AE8actincytoskeletonorganizationactinfilamentnetworkformationactinfilamentpolymerizationactinnucleationcleavagefurrowformationestablishmentofmeioticspindlelocalizationformin-nucleatedactincableassemblyGolgivesicletransportinnateimmuneresponseintracellulartransportpolarbodyextrusionaftermeioticdivisionspositiveregulationofdouble-strandbreakrepairpositiveregulationofmitochondrialfissionproteintransportvesicle-mediatedtransport
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
4.4
74
71
ODPAODPAP08559P08559acetyl-CoAbiosyntheticprocessfrompyruvateglucosemetabolicprocesstricarboxylicacidcycle
NEDD4-like E3 ubiquitin-protein ligase WWP2
4.4
77
66
WWP2WWP2O00308O00308extracellulartransportnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationofNotchsignalingpathwaynegativeregulationofproteintransportnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransporteractivitypositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinK63-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationproteinubiquitinationregulationofiontransmembranetransportregulationofmembranepotentialregulationofpotassiumiontransmembranetransporteractivitytranscriptionbyRNApolymeraseIIviralentryintohostcell
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
4.4
80
77
VIP2VIP2O43314O43314inositolmetabolicprocessinositolphosphatebiosyntheticprocessinositolphosphatemetabolicprocessphosphorylationsensoryperceptionofsound
Protein zyg-11 homolog B
4.4
66
70
ZY11BZY11BQ9C0D3Q9C0D3positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinqualitycontrolformisfoldedorincompletelysynthesizedproteins
Importin subunit alpha-7
4.4
81
67
IMA7IMA7O60684O60684entryofviralgenomeintohostnucleusthroughnuclearporecomplexviaimportinmaternalprocessinvolvedinfemalepregnancyNLS-bearingproteinimportintonucleuspositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvirallifecycleproteinimportintonucleustranscriptionbyRNApolymeraseIIviralgenomereplication
Dehydrogenase/reductase SDR family member 1
4.4
81
72
✔
DHRS1DHRS1Q96LJ7Q96LJ7
F-box only protein 5
4.1
58
83
FBX5FBX5Q9UKT4Q9UKT4celldivisionmicrotubulepolymerizationnegativeregulationofcellularsenescencenegativeregulationofDNAendoreduplicationnegativeregulationofmeioticnucleardivisionnegativeregulationofmitoticmetaphase/anaphasetransitionnegativeregulationofresponsetoDNAdamagestimulusnegativeregulationofubiquitinproteinligaseactivitynegativeregulationofubiquitin-proteintransferaseactivityoocytematurationpositiveregulationofbiomineraltissuedevelopmentpositiveregulationofcellpopulationproliferationpositiveregulationofG2/MtransitionofmitoticcellcyclepositiveregulationofmesenchymalstemcellmigrationpositiveregulationofosteoblastdifferentiationproteinubiquitinationregulationofDNAreplicationregulationofmitoticcellcycleregulationofmitoticnucleardivisionspindleassemblyinvolvedinfemalemeiosisIvesicleorganization
DNA polymerase delta subunit 2
4.4
76
67
DPOD2DPOD2P49005P49005DNAbiosyntheticprocessDNAreplicationDNAstrandelongationinvolvedinDNAreplicationDNA-templatedDNAreplicationerror-pronetranslesionsynthesis
Xaa-Pro aminopeptidase 3
4.4
88
65
XPP3XPP3Q9NQH7Q9NQH7glomerularfiltrationproteinprocessingproteolysis
Receptor of activated protein C kinase 1
4.4
91
60
✔
RACK1RACK1P63244P63244activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesscellcyclecellularresponsetoglucosestimuluscellularresponsetogrowthfactorstimuluscytoplasmictranslationgastrulationnegativeregulationofcellgrowthnegativeregulationofendoplasmicreticulumunfoldedproteinresponsenegativeregulationofgeneexpressionnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofphagocytosisnegativeregulationofproteinbindingnegativeregulationofproteinkinaseBsignalingnegativeregulationofsmoothenedsignalingpathwaynegativeregulationoftranslationnegativeregulationofWntsignalingpathwaypigmentationpositiveregulationofapoptoticprocesspositiveregulationofcellmigrationpositiveregulationofcyclic-nucleotidephosphodiesteraseactivitypositiveregulationofgastrulationpositiveregulationofGolgitoplasmamembraneproteintransportpositiveregulationofGTPaseactivitypositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofmitochondrialdepolarizationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblyproteinubiquitinationregulationofcellcycleregulationofcelldivisionregulationofestablishmentofcellpolarityregulationofproteinlocalizationrescueofstalledribosomerhythmicprocess
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
4.0
40
78
PP1APP1RBP62136O60927beta-catenindestructioncomplexdisassemblybranchingmorphogenesisofanepithelialtubecellcyclecelldivisioncircadianregulationofgeneexpressiondephosphorylationentrainmentofcircadianclockbyphotoperiodglycogenmetabolicprocesslungdevelopmentnegativeregulationofproteinbindingpeptidyl-serinedephosphorylationpeptidyl-threoninedephosphorylationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandproteindephosphorylationregulationofcanonicalWntsignalingpathwayregulationofcircadianrhythmregulationofglycogenbiosyntheticprocessregulationofglycogencatabolicprocessregulationoftranslationalinitiationbyeIF2alphadephosphorylationresponsetoleadiondefenseresponsetoGram-positivebacteriumnegativeregulationofcytokineproductionnegativeregulationofphosphoproteinphosphataseactivityubiquitin-dependentproteincatabolicprocess
Integrator complex subunit 2
4.4
82
63
INT2INT2Q9H0H0Q9H0H0regulationoftranscriptionelongationbyRNApolymeraseII"snRNA3-endprocessing"snRNAprocessing
LIM domain kinase 1
4.4
58
75
✔
LIMK1LIMK1P53667P53667actincytoskeletonorganizationaxonextensionFc-gammareceptorsignalingpathwayinvolvedinphagocytosisnegativeregulationofubiquitin-proteintransferaseactivitynervoussystemdevelopmentpositiveregulationofactinfilamentbundleassemblypositiveregulationofaxonextensionpositiveregulationofstressfiberassemblyproteinphosphorylationRhoproteinsignaltransductionsignaltransductionstressfiberassembly
Cytochrome P450 2C19
4.4
81
62
CP2CJCP2CJP33261P33261epoxygenaseP450pathwayheterocyclemetabolicprocesslong-chainfattyacidmetabolicprocessmonoterpenoidmetabolicprocessomega-hydroxylaseP450pathwayorganicacidmetabolicprocesssteroidmetabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
UDP-glucose 4-epimerase
4.4
66
71
GALEGALEQ14376Q14376galactosecatabolicprocessgalactosecatabolicprocessviaUDP-galactose
NHL repeat-containing protein 2
4.4
69
66
NHLC2NHLC2Q8NBF2Q8NBF2
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
4.4
104
61
GPDAGPDAP21695P21695cellularresponsetocAMPcellularresponsetotumornecrosisfactorgluconeogenesisglycerol-3-phosphatecatabolicprocessglycerol-3-phosphatemetabolicprocessglycerolipidmetabolicprocessglycerophosphateshuttleNADHmetabolicprocessNADHoxidationpositiveregulationofglycolyticprocess
NADP-dependent malic enzyme
4.4
85
63
MAOXMAOXP48163P48163carbohydratemetabolicprocessmalatemetabolicprocessNADHmetabolicprocessNADPmetabolicprocessnucleotidebiosyntheticprocessproteinhomotetramerizationpyruvatemetabolicprocessregulationofNADPmetabolicprocessresponsetocarbohydrateresponsetohormone
AP-2 complex subunit beta
4.4
77
72
AP2B1AP2B1P63010P63010aortadevelopmentclathrin-dependentendocytosiscoronaryvasculaturedevelopmentintracellularproteintransportkidneydevelopmentpostsynapticneurotransmitterreceptorinternalizationsynapticvesicleendocytosisventricularseptumdevelopmentvesicle-mediatedtransport
Interferon-induced GTP-binding protein Mx1
4.4
60
70
MX1MX1P20591P20591antiviralinnateimmuneresponseapoptoticprocessdefenseresponsedefenseresponsetovirusinnateimmuneresponseinterleukin-27-mediatedsignalingpathwaynegativeregulationofviralgenomereplicationresponsetotypeIinterferonresponsetovirussignaltransduction
Acylpyruvase FAHD1, mitochondrial
4.4
100
64
FAHD1FAHD1Q6P587Q6P587pyruvatemetabolicprocess
cGMP-dependent protein kinase 2
4.4
53
69
KGP2KGP2Q13237Q13237negativeregulationofchloridetransportpeptidyl-serineautophosphorylationpositiveregulationofchondrocytedifferentiationpositiveregulationofproteinlocalizationproteinlocalizationtoplasmamembraneproteinphosphorylationsignaltransductiontetrahydrobiopterinmetabolicprocess
N-acetylglucosamine-6-phosphate deacetylase
4.4
54
78
NAGANAGAQ9Y303Q9Y303carbohydratemetabolicprocessN-acetylglucosaminecatabolicprocessN-acetylneuraminatecatabolicprocessUDP-N-acetylglucosaminebiosyntheticprocess
Dehydrogenase/reductase SDR family member 6
4.4
84
64
DHRS6DHRS6Q9BUT1Q9BUT1epithelialcelldifferentiationfattyacidbeta-oxidationhememetabolicprocessironionhomeostasissiderophorebiosyntheticprocess
tRNA N(3)-methylcytidine methyltransferase METTL6
4.4
73
66
METL6METL6Q8TCB7Q8TCB7tRNAmethylation
Ubiquitin-like modifier-activating enzyme 6
4.4
86
63
UBA6UBA6A0AVT1A0AVT1amygdaladevelopmentcellularresponsetoDNAdamagestimulusdendriticspinedevelopmenthippocampusdevelopmentlearninglocomotorybehaviorproteinmodificationbysmallproteinconjugationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
Tumor necrosis factor receptor superfamily, member 25
4.4
82
65
B1AWN9B1AWN9B1AWN9B1AWN9apoptoticprocesssignaltransduction
Synaptojanin-1
4.4
102
61
SYNJ1SYNJ1O43426O43426braindevelopmentinositolphosphatedephosphorylationinositolphosphatemetabolicprocesslearningmembraneorganizationneurotransmittertransportphosphatidylinositolbiosyntheticprocessphosphatidylinositoldephosphorylationphosphatidylinositolmetabolicprocesspositiveregulationofendosomeorganizationpositiveregulationofgliogenesispositiveregulationofreceptor-mediatedendocytosisresponsetocytokineresponsetoretinoicacidsynapticvesicleendocytosissynapticvesicleprimingsynapticvesicletransportsynapticvesicleuncoating
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1
4.4
82
64
NMNA1NMNA1Q9HAN9Q9HAN9ATPgenerationfrompoly-ADP-D-riboseNADbiosyntheticprocessnegativeregulationofneurondeathnucleotidebiosyntheticprocessresponsetowounding
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
4.4
93
64
✔
ODP2ODP2P10515P10515acetyl-CoAbiosyntheticprocessfrompyruvateglucosemetabolicprocesstricarboxylicacidcycle
Importin subunit alpha-3
4.4
60
76
IMA3IMA3O00629O00629NLS-bearingproteinimportintonucleusproteinimportintonucleus
Protein-tyrosine kinase 6
4.4
53
73
PTK6PTK6Q13882Q13882celldifferentiationcellmigrationcellularresponsetoretinoicacidERBB2signalingpathwayinnateimmuneresponseintestinalepithelialcelldifferentiationnegativeregulationofgrowthnegativeregulationofproteintyrosinekinaseactivitypositiveregulationofcellcyclepositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofneuronprojectiondevelopmentpositiveregulationoftyrosinephosphorylationofSTATproteinproteinautophosphorylationproteinphosphorylationtransmembranereceptorproteintyrosinekinasesignalingpathwaytyrosinephosphorylationofSTATprotein
START domain-containing protein 10
4.4
65
73
STA10STA10Q9Y365Q9Y365lipidtransport
Enhancer of mRNA-decapping protein 3
4.4
72
68
EDC3EDC3Q96F86Q96F86deadenylation-independentdecappingofnuclear-transcribedmRNAP-bodyassembly
Rho guanine nucleotide exchange factor TIAM1
4.4
76
67
TIAM1TIAM1Q13009Q13009activationofGTPaseactivitycellmigrationcell-matrixadhesionephrinreceptorsignalingpathwaypositiveregulationofaxonogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofproteinbindingprotein-containingcomplexassemblyRacproteinsignaltransductionregulationofdopaminergicneurondifferentiationregulationofepithelialtomesenchymaltransitionregulationofnon-canonicalWntsignalingpathwayregulationofsmallGTPasemediatedsignaltransductionsmallGTPasemediatedsignaltransductionWntsignalingpathwayplanarcellpolaritypathway
NACHT, LRR and PYD domains-containing protein 1
4.4
66
72
NLRP1NLRP1Q9C000Q9C000activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessantiviralinnateimmuneresponseapoptoticprocesscellularresponsetoUV-BdefenseresponsetobacteriumdefenseresponsetovirusinflammatoryresponseneuronapoptoticprocessNLRP1inflammasomecomplexassemblypatternrecognitionreceptorsignalingpathwaypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionproteinhomooligomerizationpyroptosisregulationofapoptoticprocessregulationofinflammatoryresponseresponsetomuramyldipeptideselfproteolysisstress-activatedproteinkinasesignalingcascade
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
4.4
82
66
✔
CAPAMCAPAMQ9H4Z3Q9H4Z3mRNAmethylationnegativeregulationoftranslationpositiveregulationoftranslation
Pseudouridylate synthase 1 homolog
4.4
70
74
PUS1PUS1Q9Y606Q9Y606mitochondrialtRNApseudouridinesynthesismRNAprocessingmRNApseudouridinesynthesisRNAsplicingtRNApseudouridinesynthesis
Phospholipid-transporting ATPase IC
4.7
98
60
AT8B1AT8B1O43520O43520apicalproteinlocalizationbileacidandbilesalttransportbileacidmetabolicprocessGolgiorganizationinnerearreceptorcelldevelopmentiontransmembranetransportnegativeregulationofDNA-templatedtranscriptionphospholipidtranslocationregulationofchloridetransportregulationofmicrovillusassemblyregulationofplasmamembraneorganizationsensoryperceptionofsoundvestibulocochlearnerveformationxenobiotictransmembranetransport
Acetylserotonin O-methyltransferase
4.5
75
72
ASMTASMTP46597P46597aromaticcompoundbiosyntheticprocessindolalkylaminebiosyntheticprocesslipidmetabolicprocessmelatoninbiosyntheticprocessmethylationtranslation
COP9 signalosome complex subunit 7b
4.5
78
66
CSN7BCSN7BQ9H9Q2Q9H9Q2COP9signalosomeassemblyproteindeneddylationproteinneddylationregulationofproteinneddylation
Solute carrier family 12 member 2
4.5
47
78
S12A2S12A2P55011P55011agingammoniumtransmembranetransportcellvolumehomeostasiscellularchlorideionhomeostasiscellularpotassiumionhomeostasiscellularresponsetochemokinecellularresponsetopotassiumioncellularsodiumionhomeostasischlorideionhomeostasischloridetransmembranetransportgamma-aminobutyricacidsignalingpathwayhyperosmoticresponseinorganicanionimportacrossplasmamembraneinorganiccationimportacrossplasmamembraneiontransportmaintenanceofblood-brainbarriernegativeregulationofvascularwoundhealingpositiveregulationofaspartatesecretionpositiveregulationofcellvolumepotassiumionhomeostasispotassiumionimportacrossplasmamembraneregulationofmatrixmetallopeptidasesecretionregulationofspontaneoussynaptictransmissionsodiumionhomeostasissodiumionimportacrossplasmamembranesodiumiontransmembranetransportTcellchemotaxistransepithelialammoniumtransporttransepithelialchloridetransporttransportacrossblood-brainbarrier
Amine oxidase [flavin-containing] A
4.5
76
63
AOFAAOFAP21397P21397biogenicaminemetabolicprocessdopaminecatabolicprocessneurotransmittercatabolicprocesspositiveregulationofsignaltransduction
Cytochrome P450 7A1
4.5
71
68
CP7A1CP7A1P22680P22680bileacidandbilesalttransportbileacidbiosyntheticprocessbileacidsignalingpathwaycellularresponsetocholesterolcellularresponsetoglucosestimuluscholesterolcatabolicprocesscholesterolhomeostasisnegativeregulationofcollagenbiosyntheticprocessnegativeregulationoffattyacidbiosyntheticprocesspositiveregulationofcholesterolbiosyntheticprocessregulationofbileacidbiosyntheticprocessregulationofgeneexpressionresponsetoethanolsterolmetabolicprocess
Ubiquitin-associated and SH3 domain-containing protein A
4.5
76
68
UBS3AUBS3AP57075P57075negativeregulationofTcellreceptorsignalingpathwayregulationofcytokineproduction
CMP-sialic acid transporter
4.5
65
72
S35A1S35A1Q61420Q61420carbohydratetransportCMP-N-acetylneuraminatetransmembranetransport
T-complex protein 1 subunit zeta
4.5
71
75
✔
TCPZTCPZP40227P40227chaperone-mediatedproteinfoldingpositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilization
Serine-protein kinase ATM
3.5
62
84
ATMATMQ13315Q13315braindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetonitrosativestresscellularresponsetoretinoicacidcellularresponsetoX-raycellularsenescencedeterminationofadultlifespanDNAdamagecheckpointsignalingDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningestablishmentofprotein-containingcomplexlocalizationtotelomereestablishmentofRNAlocalizationtotelomerefemalemeioticnucleardivisionheartdevelopmenthistonemRNAcatabolicprocessintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagelipoproteincatabolicprocessmalemeioticnucleardivisionmeiotictelomereclusteringmitoticG2DNAdamagecheckpointsignalingmitoticspindleassemblycheckpointsignalingmulticellularorganismgrowthnegativeregulationofBcellproliferationnegativeregulationoftelomerecappingnegativeregulationofTORC1signalingneuronapoptoticprocessoocytedevelopmentovarianfollicledevelopmentpeptidyl-serineautophosphorylationpeptidyl-serinephosphorylationpexophagypositiveregulationofapoptoticprocesspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofDNAcatabolicprocesspositiveregulationofDNAdamageresponsesignaltransductionbyp53classmediatorpositiveregulationofgeneexpressionpositiveregulationofneuronapoptoticprocesspositiveregulationoftelomerasecatalyticcorecomplexassemblypositiveregulationoftelomeremaintenanceviatelomerasepositiveregulationoftelomeremaintenanceviatelomerelengtheningpositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicdevelopmentpre-Bcellallelicexclusionproteinautophosphorylationproteinphosphorylationreciprocalmeioticrecombinationregulationofapoptoticprocessregulationofautophagyregulationofcellcycleregulationofcellularresponsetogammaradiationregulationofcellularresponsetoheatregulationofmicroglialcellactivationregulationofsignaltransductionbyp53classmediatorregulationoftelomeremaintenanceviatelomerasereplicativesenescenceresponsetohypoxiaresponsetoionizingradiationsignaltransductionsignaltransductioninresponsetoDNAdamagesomitogenesistelomeremaintenancethymusdevelopmentV(D)Jrecombination
40S ribosomal protein S21
4.5
84
70
✔
RS21RS21P63220P63220cytoplasmictranslationendonucleolyticcleavageinITS1toseparateSSU-rRNAfrom5.8SrRNAandLSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"endonucleolyticcleavagetogeneratemature3-endofSSU-rRNAfrom(SSU-rRNA5.8SrRNALSU-rRNA)"translation
Deoxyhypusine synthase
4.5
80
67
DHYSDHYSP49366P49366glucosehomeostasispeptidyl-lysinemodificationtopeptidyl-hypusinepositiveregulationofcellpopulationproliferationpositiveregulationofTcellproliferationspermidinecatabolicprocessspermidinemetabolicprocesstranslation
Brain-specific angiogenesis inhibitor 1-associated protein 2
4.5
66
76
BAIP2BAIP2Q9UQB8Q9UQB8actincrosslinkformationactinfilamentbundleassemblyaxonogenesisbraindevelopmentcellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoL-glutamatedendritedevelopmentinsulinreceptorsignalingpathwayplasmamembraneorganizationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofactinfilamentpolymerizationpositiveregulationofdendriticspinemorphogenesispositiveregulationofexcitatorypostsynapticpotentialproteinlocalizationtosynapseregulationofactincytoskeletonorganizationregulationofcellshaperegulationofmodificationofpostsynapticactincytoskeletonregulationofsynapticplasticityresponsetobacterium
CCR4-NOT transcription complex subunit 6-like
4.5
98
62
CNO6LCNO6LQ96LI5Q96LI5mRNAprocessingnuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationofcellpopulationproliferationpositiveregulationofcytoplasmicmRNAprocessingbodyassemblyRNA-mediatedgenesilencing
Calmodulin-regulated spectrin-associated protein 1
5.3
53
71
CAMP1CAMP1Q5T5Y3Q5T5Y3cytoplasmicmicrotubuleorganizationcytoskeletonorganizationmicrotubulecytoskeletonorganizationnegativeregulationofmicrotubuledepolymerizationneuronprojectiondevelopmentregulationofcellmorphogenesisregulationofmicrotubulepolymerization
Exocyst complex component 2
4.5
66
73
EXOC2EXOC2O54921O54921exocytosisGolgitoplasmamembranetransportproteintransportregulationofentryofbacteriumintohostcellvesicledockinginvolvedinexocytosis
Ribonuclease 3
4.5
51
78
RNCRNCQ9NRR4Q9NRR4defenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriummiRNAmetabolicprocesspositiveregulationofgeneexpressionpre-miRNAprocessingprimarymiRNAprocessingregulationofgeneexpressionregulationofinflammatoryresponseregulationofmiRNAmetabolicprocessregulationofregulatoryTcelldifferentiationRNAprocessingrRNAprocessing
Oxysterol-binding protein-related protein 3
4.5
81
70
OSBL3OSBL3Q9H4L5Q9H4L5bileacidbiosyntheticprocess
Potassium-transporting ATPase alpha chain 1
4.3
75
71
ATP4AATP4AP19156P19156
Fibroblast growth factor receptor substrate 2
4.5
57
74
FRS2FRS2Q8WU20Q8WU20anterior/posterioraxisspecificationembryofibroblastgrowthfactorreceptorsignalingpathwayforebraindevelopmentGprotein-coupledreceptorsignalingpathwaygastrulationwithmouthformingsecondlensfibercelldevelopmentlensplacodeformationinvolvedincamera-typeeyeformationnegativeregulationofcardiacmusclecelldifferentiationneuroblastproliferationorganinductionpositiveregulationofMAPKcascadepositiveregulationofvascularassociatedsmoothmusclecellproliferationprostateepithelialcordarborizationinvolvedinprostateglandularacinusmorphogenesisregulationofapoptoticprocessregulationofepithelialcellproliferationregulationofERK1andERK2cascadetransmembranereceptorproteintyrosinekinasesignalingpathwaytransmembranereceptorproteintyrosinephosphatasesignalingpathwayventricularseptumdevelopment
Fumarate hydratase, mitochondrial
4.5
73
69
FUMHFUMHP07954P07954cellularresponsetoDNAdamagestimulusDNArepairfumaratemetabolicprocesshomeostasisofnumberofcellswithinatissuemalatemetabolicprocessnegativeregulationofhistoneH3-K36methylationpositiveregulationofcold-inducedthermogenesispositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningregulationofargininemetabolicprocesstricarboxylicacidcycleureacycle
Serum amyloid P-component
4.5
90
70
SAMPSAMPP02743P02743acute-phaseresponsechaperone-mediatedproteincomplexassemblyinnateimmuneresponsenegativeregulationbyhostofviralexo-alpha-sialidaseactivitynegativeregulationbyhostofviralglycoproteinmetabolicprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationofexo-alpha-sialidaseactivitynegativeregulationofglycoproteinmetabolicprocessnegativeregulationofmonocytedifferentiationnegativeregulationofviralentryintohostcellnegativeregulationofviralprocessnegativeregulationofwoundhealingproteinfolding
Cullin-associated NEDD8-dissociated protein 1
4.5
77
70
CAND1CAND1Q86VP6Q86VP6celldifferentiationnegativeregulationofcatalyticactivitypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblyproteinubiquitinationSCFcomplexassembly
Transient receptor potential cation channel subfamily V member 1
4.5
54
82
I3LZN5I3LZN5I3LZN5I3LZN5behavioralresponsetopaincalciumionimportacrossplasmamembranecellularresponsetoacidicpHcellularresponsetoheatdetectionofchemicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinthermoceptiondietinducedthermogenesisfevergenerationlipidmetabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidesecretionresponsetocapsazepinesensoryperceptionofmechanicalstimulussmoothmusclecontractioninvolvedinmicturition
Tyrosine--tRNA ligase, cytoplasmic
4.5
66
72
✔
SYYCSYYCP54577P54577apoptoticprocesstyrosyl-tRNAaminoacylation
Muskelin
4.5
52
73
MKLN1MKLN1Q99PV3Q99PV3actincytoskeletonreorganizationcell-matrixadhesionregulationofcellshaperegulationofreceptorinternalization
Intraflagellar transport protein 140 homolog
4.5
71
68
IF140IF140Q96RY7Q96RY7ciliumassemblydeterminationofleft/rightsymmetryembryonicbraindevelopmentembryoniccamera-typeeyedevelopmentembryoniccranialskeletonmorphogenesisembryonicdigitmorphogenesisheartdevelopmentintraciliaryretrogradetransportintraciliarytransportneuraltubepatterningnon-motileciliumassemblyphotoreceptorcelloutersegmentorganizationproteinlocalizationtociliumregulationofciliumassemblyregulationofsmoothenedsignalingpathway
Histone PARylation factor 1
4.5
70
70
✔
HPF1HPF1Q9NWY4Q9NWY4cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairregulationofhistonemodificationregulationofproteinADP-ribosylation
Eukaryotic translation initiation factor 3 subunit C
4.5
81
66
G1U971G1U971G1U971G1U971formationofcytoplasmictranslationinitiationcomplex
Apoptosis-resistant E3 ubiquitin protein ligase 1
4.5
76
66
AREL1AREL1O15033O15033apoptoticprocessnegativeregulationofapoptoticprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK11-linkedubiquitinationproteinK33-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofinflammatoryresponseubiquitin-dependentproteincatabolicprocess
Nipped-B-like protein
4.5
63
73
NIPBLNIPBLQ6KC79Q6KC79braindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetoX-raycognitiondevelopmentalgrowthdigestivetractdevelopmentearmorphogenesisembryonicdigestivetractmorphogenesisembryonicforelimbmorphogenesisembryonicviscerocraniummorphogenesisestablishmentofmitoticsisterchromatidcohesionestablishmentofproteinlocalizationtochromatinexternalgenitaliamorphogenesiseyemorphogenesisfacemorphogenesisfatcelldifferentiationforelimbmorphogenesisgallbladderdevelopmentheartmorphogenesismaintenanceofmitoticsisterchromatidcohesionmetanephrosdevelopmentmitoticcohesinloadingmitoticsisterchromatidcohesionnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIoutflowtractmorphogenesispositiveregulationofhistonedeacetylationpositiveregulationofmulticellularorganismgrowthpositiveregulationofneuronmigrationpositiveregulationofossificationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationregulationofdevelopmentalgrowthregulationofembryonicdevelopmentregulationofhaircyclereplication-borndouble-strandbreakrepairviasisterchromatidexchangesensoryperceptionofsoundsomaticstemcellpopulationmaintenanceuterusmorphogenesis
Stimulator of interferon genes protein
4.5
62
75
STINGSTINGQ86WV6Q86WV6activationofinnateimmuneresponseautophagosomeassemblycellularresponsetoexogenousdsRNAcellularresponsetointerferon-betacellularresponsetoorganiccycliccompounddefenseresponsetovirusinnateimmuneresponsepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofinterferon-betaproductionpositiveregulationofmacroautophagypositiveregulationofproteinbindingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayproteincomplexoligomerizationregulationofinflammatoryresponsereticulophagy
Guanylate cyclase soluble subunit alpha-1
4.5
43
75
GCYA1GCYA1Q02108Q02108bloodcirculationcGMPbiosyntheticprocesscGMP-mediatedsignalingnitricoxidemediatedsignaltransductionnitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofnitricoxidemediatedsignaltransductionregulationofbloodpressurerelaxationofvascularassociatedsmoothmuscleresponsetooxygenlevelsretrogradetrans-synapticsignalingbynitricoxidemodulatingsynaptictransmission
Sentrin-specific protease 7
4.5
82
61
SENP7SENP7Q9BQF6Q9BQF6antiviralinnateimmuneresponseproteindesumoylation
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
4.5
47
75
AB1IPAB1IPQ8R5A3Q8R5A3positiveregulationofcelladhesionsignaltransductionTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcell
PRMT3 protein
4.5
74
69
Q8WUV3Q8WUV3Q8WUV3Q8WUV3peptidyl-argininemethylation
Coronin-1C
4.5
92
64
COR1CCOR1CQ9ULV4Q9ULV4actinfilamentorganizationactivationofGTPaseactivitycellmigrationcorpuscallosumdevelopmentendosomaltransportendosomefissionendosomemembranetubulationestablishmentofproteinlocalizationmembranefissionnegativeregulationofepithelialcellmigrationnegativeregulationoffocaladhesionassemblynegativeregulationofproteinkinaseactivitybyregulationofproteinphosphorylationnegativeregulationofproteinphosphorylationnegativeregulationofsubstrateadhesion-dependentcellspreadingneuralcrestcellmigrationphagocytosispositiveregulationoflamellipodiummorphogenesisregulationofepithelialcellmigrationregulationoffibroblastmigrationregulationoffocaladhesionassemblyregulationofproteinphosphorylationregulationofruffleassemblyregulationofsubstrateadhesion-dependentcellspreadingsignaltransductionventricularsystemdevelopment
5' exonuclease Apollo
4.5
58
79
DCR1BDCR1BQ9H816Q9H816double-strandbreakrepairvianonhomologousendjoininginterstrandcross-linkrepairprotectionfromnon-homologousendjoiningattelomeretelomerecappingtelomeremaintenancetelomeremaintenanceviatelomerelengthening"telomeric3overhangformation"telomericloopformation
Phospholipid-transporting ATPase
4.5
89
65
Q59EX4Q59EX4Q59EX4Q59EX4phospholipidtransport
Caspase-1
4.5
67
74
CASP1CASP1P29466P29466apoptoticprocesscellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetoorganicsubstancecellularresponsetotypeIIinterferoncytokineprecursorprocessingdefenseresponsetovirusicosanoidbiosyntheticprocessosmosensorysignalingpathwaypatternrecognitionreceptorsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofneuronapoptoticprocesspositiveregulationofreleaseofcytochromecfrommitochondriapositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinautoprocessingproteolysispyroptosisregulationofapoptoticprocessregulationofinflammatoryresponsesignaltransductionsignalingreceptorligandprecursorprocessing
Sulfide:quinone oxidoreductase, mitochondrial
4.5
83
63
✔
SQORSQORQ9Y6N5Q9Y6N5sulfideoxidationusingsulfide
H(+)/Cl(-) exchange transporter 7
4.5
57
72
CLCN7CLCN7P51798P51798responsetopHtransepithelialchloridetransport
Bile acid receptor
4.5
73
71
NR1H4NR1H4Q96RI1Q96RI1bileacidmetabolicprocessbileacidsignalingpathwaycelldifferentiationcell-celljunctionassemblycellularglucosehomeostasiscellularresponsetobileacidcellularresponsetofattyacidcellularresponsetolipopolysaccharidecellularresponsetoorganonitrogencompoundcellulartriglyceridehomeostasischolesterolhomeostasisdefenseresponsetobacteriumfattyacidhomeostasisinflammatoryresponseinnateimmuneresponseintracellularbileacidreceptorsignalingpathwayintracellularreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-2productionnegativeregulationofinterleukin-6productionnegativeregulationofmonocytechemotacticprotein-1productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactorproductionnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynegativeregulationoftypeIIinterferonproductionnegativeregulationofvery-low-densitylipoproteinparticleremodelingnitrogencataboliteactivationoftranscriptionfromRNApolymeraseIIpromoterNotchsignalingpathwaypositiveregulationofadiposetissuedevelopmentpositiveregulationofammoniaassimilationcyclepositiveregulationofDNA-templatedtranscriptionpositiveregulationofglutamatemetabolicprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofinterleukin-17productionpositiveregulationofphosphatidicacidbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofbileacidbiosyntheticprocessregulationofcholesterolmetabolicprocessregulationofDNA-templatedtranscriptionregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusregulationoflow-densitylipoproteinparticleclearanceregulationoftranscriptionbyRNApolymeraseIIregulationofureametabolicprocesstoll-likereceptor4signalingpathwaytoll-likereceptor9signalingpathwaytranscriptionbyRNApolymeraseII
Tyrosyl-DNA phosphodiesterase 2
2.0
61
84
TYDP2TYDP2Q9JJX7Q9JJX7double-strandbreakrepairneurondevelopment
Myosin-binding protein C, cardiac-type
4.9
68
67
MYPC3MYPC3O70468O70468cardiacmusclecontractioncelladhesionheartmorphogenesismusclecontractionmyosinfilamentassemblyregulationofheartcontractionregulationofheartratesarcomereorganizationventricularcardiacmuscletissuemorphogenesis
Mothers against decapentaplegic homolog 7
4.5
88
61
SMAD7SMAD7O35253O35253adherensjunctionassemblyanatomicalstructuremorphogenesisarterymorphogenesiscelldifferentiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetotransforminggrowthfactorbetastimulusintracellularsignaltransductionnegativeregulationofBMPsignalingpathwaynegativeregulationofchondrocyteproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofossificationnegativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofproteinubiquitinationnegativeregulationofTcellcytokineproductionnegativeregulationofT-helper17celldifferentiationnegativeregulationofT-helper17typeimmuneresponsenegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationofubiquitin-proteintransferaseactivitypathway-restrictedSMADproteinphosphorylationpositiveregulationofcell-celladhesionpositiveregulationofchondrocytehypertrophypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteinstabilizationprotein-containingcomplexlocalizationregulationofactivinreceptorsignalingpathwayregulationofcardiacmusclecontractionregulationofepithelialtomesenchymaltransitionregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofventricularcardiacmusclecellmembranedepolarizationresponsetolaminarfluidshearstressSMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentventricularcardiacmuscletissuemorphogenesisventricularseptummorphogenesis
Glycerol-3-phosphate dehydrogenase 1-like protein
4.5
72
70
GPD1LGPD1LQ8N335Q8N335carbohydratemetabolicprocessglycerol-3-phosphatecatabolicprocessNADmetabolicprocessNADHmetabolicprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofproteinkinaseCsignalingpositiveregulationofproteinlocalizationtocellsurfacepositiveregulationofsodiumiontransportregulationofheartrateregulationofsodiumiontransmembranetransporteractivityregulationofventricularcardiacmusclecellmembranedepolarizationventricularcardiacmusclecellactionpotential
SRSF protein kinase 2
4.5
61
75
SRPK2SRPK2P78362P78362angiogenesiscelldifferentiationinnateimmuneresponseintracellularsignaltransductionnegativeregulationofviralgenomereplicationnuclearspeckorganizationpeptidyl-serinephosphorylationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofneuronapoptoticprocesspositiveregulationofviralgenomereplicationproteinphosphorylationR-loopprocessingregulationofmRNAprocessingregulationofmRNAsplicingviaspliceosomeRNAsplicingspliceosomalcomplexassembly
Centromere protein P
4.6
67
73
✔
CENPPCENPPQ6IPU0Q6IPU0CENP-Acontainingchromatinassembly
Mitotic spindle assembly checkpoint protein MAD1
4.6
83
66
MD1L1MD1L1Q9Y6D9Q9Y6D9attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncytoplasmicsequesteringofproteindeactivationofmitoticspindleassemblycheckpointmitoticspindleassemblycheckpointsignalingnegativeregulationofTcellproliferationpositiveregulationofmitoticcellcyclespindleassemblycheckpointregulationofmetaphaseplatecongressionthymusdevelopment
Protein-arginine deiminase type-1
4.6
71
71
PADI1PADI1Q9ULC6Q9ULC6
Copper-transporting ATPase 2
4.6
59
75
ATP7BATP7BP35670P35670cellularcopperionhomeostasiscellularzincionhomeostasiscopperionexportcopperionhomeostasiscopperionimportcopperiontransportestablishmentoflocalizationincelliontransmembranetransportlactationproteinmaturationbycopperiontransferresponsetocopperionsequesteringofcalciumionxenobioticdetoxificationbytransmembraneexportacrosstheplasmamembrane
Defensin-6
2.0
51
86
DEF6DEF6Q01524Q01524antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosakillingofcellsofanotherorganism
Glutamine--tRNA ligase
4.6
78
71
SYQSYQP47897P47897braindevelopmentglutaminyl-tRNAaminoacylationnegativeregulationofapoptoticsignalingpathwaynegativeregulationofDNA-templatedtranscriptionnegativeregulationofproteinkinaseactivitynegativeregulationofstress-activatedMAPKcascadetRNAaminoacylationforproteintranslation
Adenylyl cyclase-associated protein 1
2.0
63
87
CAP1CAP1P40124P40124actincytoskeletonorganizationameboidal-typecellmigrationcAMP-mediatedsignalingcellmorphogenesisreceptor-mediatedendocytosisregulationofadenylatecyclaseactivity
Solute carrier family 15 member 2
4.6
48
73
S15A2S15A2Q16348Q16348dipeptideimportacrossplasmamembranedipeptidetransportinnateimmuneresponseiontransportpeptidoglycantransportproteintransportregulationofnucleotide-bindingoligomerizationdomaincontainingsignalingpathwayrenalabsorptiontransmembranetransporttransportacrossblood-brainbarrierxenobioticdetoxificationbytransmembraneexportacrosstheplasmamembranexenobiotictransport
Endothelin-3
2.1
nan
85
EDN3EDN3P14138P14138axonextensionaxonguidancebloodcirculationcellpopulationproliferationcellsurfacereceptorsignalingpathwaycell-cellsignalingcellularcalciumionhomeostasiscellularmagnesiumionhomeostasisestablishmentoflocalizationincellinositolphosphate-mediatedsignalingmelanocytedifferentiationneuralcrestcellmigrationneutrophilchemotaxispeptidehormonesecretionpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofheartratepositiveregulationofhormonesecretionpositiveregulationofleukocytechemotaxispositiveregulationofMAPkinaseactivitypositiveregulationofmitoticnucleardivisionpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofprostaglandin-endoperoxidesynthaseactivitypotassiumiontransmembranetransportregulationofdevelopmentalpigmentationregulationofgeneexpressionregulationofsystemicarterialbloodpressurebyendothelinregulationofvasoconstrictionsignaltransductionvasoconstrictionveinsmoothmusclecontraction
Ubiquitin carboxyl-terminal hydrolase MINDY-1
4.6
49
73
MINY1MINY1Q8N5J2Q8N5J2proteinK48-linkeddeubiquitination
DNA-dependent protein kinase catalytic subunit
4.6
57
73
PRKDCPRKDCP78527P78527activationofinnateimmuneresponseBcelllineagecommitmentbraindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetoinsulinstimulusdouble-strandbreakrepairdouble-strandbreakrepairviaalternativenonhomologousendjoiningdouble-strandbreakrepairvianonhomologousendjoiningectopicgermcellprogrammedcelldeathheartdevelopmentimmatureBcelldifferentiationimmunoglobulinV(D)JrecombinationinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagematurationof5.8SrRNAmitoticG1DNAdamagecheckpointsignalingnegativeregulationofapoptoticprocessnegativeregulationofproteinphosphorylationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationoferythrocytedifferentiationpositiveregulationoflymphocytedifferentiationpositiveregulationofplateletformationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationpro-Bcelldifferentiationproteindestabilizationproteinmodificationprocessproteinphosphorylationregulationofcircadianrhythmregulationofepithelialcellproliferationregulationofhematopoieticstemcelldifferentiationregulationofsmoothmusclecellproliferationresponsetogammaradiationrhythmicprocesssmall-subunitprocessomeassemblysomitogenesisTcelldifferentiationinthymusTcelllineagecommitmentTcellreceptorV(D)Jrecombinationtelomerecappingtelomeremaintenance
Histidine decarboxylase
4.6
92
62
DCHSDCHSP19113P19113catecholaminebiosyntheticprocesshistaminebiosyntheticprocesshistidinecatabolicprocesshistidinemetabolicprocess
Nucleoprotein TPR
4.6
54
72
TPRTPRP12270P12270celldivisioncellularresponsetoheatcellularresponsetointerferon-alphamitoticspindleassemblycheckpointsignalingmRNAexportfromnucleusmRNAexportfromnucleusinresponsetoheatstressnegativeregulationofRNAexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranslationalinitiationnuclearporeorganizationnucleocytoplasmictransportpositiveregulationofheterochromatinformationpositiveregulationofintracellularproteintransportpositiveregulationofmitoticcellcyclespindleassemblycheckpointpositiveregulationofproteinexportfromnucleuspositiveregulationofproteinimportintonucleusproteinimportintonucleusregulationofmitoticsisterchromatidseparationregulationofmitoticspindleassemblyregulationofproteinlocalizationresponsetoepidermalgrowthfactorRNAexportfromnucleusRNAimportintonucleus
Probable crossover junction endonuclease EME2
4.6
62
69
EME2EME2A4GXA9A4GXA9double-strandbreakrepairmitoticintra-SDNAdamagecheckpointsignalingreplicationforkprocessingresolutionofmeioticrecombinationintermediates
Heat shock protein 105 kDa
4.6
74
74
HS105HS105Q92598Q92598chaperonecofactor-dependentproteinrefoldingpositiveregulationofMHCclassIbiosyntheticprocesspositiveregulationofNKTcellactivationproteinfoldingresponsetounfoldedprotein
High mobility group protein B3
4.7
48
71
✔
HMGB3HMGB3O15347O15347DNAgeometricchangeDNArecombinationinnateimmuneresponsenegativeregulationofBcelldifferentiationnegativeregulationofmyeloidcelldifferentiationregulationoftranscriptionbyRNApolymeraseII
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
4.7
97
61
PP1BPP1BP62140P62140cellcyclecelldivisioncircadianregulationofgeneexpressionentrainmentofcircadianclockbyphotoperiodglycogenmetabolicprocessMAPKcascadeproteindephosphorylationregulationofcelladhesionregulationofcircadianrhythm
Importin-13
4.7
59
75
IPO13IPO13O94829O94829proteinimportintonucleus
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
4.7
101
60
SSU72SSU72Q9NP77Q9NP77dephosphorylationofRNApolymeraseIIC-terminaldomainmRNApolyadenylationterminationofRNApolymeraseIItranscription
AT-rich interactive domain-containing protein 1A
4.7
79
61
ARI1AARI1AO14497O14497androgenreceptorsignalingpathwaychromatinremodelingglucocorticoidreceptorsignalingpathwayintracellularestrogenreceptorsignalingpathwaynervoussystemdevelopmentnucleosomedisassemblypositiveregulationofcelldifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiation-coupledchromatinremodeling
Bestrophin
4.7
98
62
E1BF86E1BF86E1BF86E1BF86
WD_REPEATS_REGION domain-containing protein
4.7
101
62
G1SJB4G1SJB4G1SJB4G1SJB4cellularresponsetoglucosestimuluscellularresponsetogrowthfactorstimulusgastrulationnegativeregulationofcellgrowthnegativeregulationofgeneexpressionnegativeregulationofhydrogenperoxide-inducedneurondeathnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofphagocytosisnegativeregulationofproteinbindingnegativeregulationofproteinkinaseBsignalingnegativeregulationofsmoothenedsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcyclic-nucleotidephosphodiesteraseactivitypositiveregulationofGolgitoplasmamembraneproteintransportpositiveregulationofGTPaseactivitypositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofmitochondrialdepolarizationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblyproteinubiquitinationregulationofcellcyclerescueofstalledribosome
SEC14-like protein 4
4.7
68
66
S14L4S14L4Q9UDX3Q9UDX3
Inositol-trisphosphate 3-kinase A
4.7
60
66
IP3KAIP3KAP23677P23677actincytoskeletonorganizationcellularresponsetocalciumiondendriticspinemaintenanceinositolmetabolicprocessinositolphosphatebiosyntheticprocessmodificationofpostsynapticactincytoskeletonphosphatidylinositolphosphatebiosyntheticprocessphosphorylationpositiveregulationofdendriticspinemorphogenesisregulationofsynapticplasticityresponsetocalciumionsignaltransduction
Ribose-phosphate pyrophosphokinase 1
4.7
65
74
PRPS1PRPS1P60891P608915-phosphoribose1-diphosphatebiosyntheticprocesshypoxanthinebiosyntheticprocessnervoussystemdevelopmentphosphorylationpurinenucleobasemetabolicprocesspurinenucleotidebiosyntheticprocesspyrimidinenucleotidebiosyntheticprocessribonucleosidemonophosphatebiosyntheticprocessuratebiosyntheticprocess
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
4.7
56
65
✔
DECR2DECR2Q9NUI1Q9NUI1fattyacidbeta-oxidationusingacyl-CoAoxidasefattyacidmetabolicprocessunsaturatedfattyacidbiosyntheticprocess
Kalirin
4.7
49
74
KALRNKALRNP97924P97924adultlocomotorybehavioraxonguidanceaxonogenesishabituationintracellularsignaltransductionlactationmaternalbehaviormaternalprocessinvolvedinparturitionmemorymodificationofpostsynapticactincytoskeletonnegativeregulationofgrowthhormonesecretionnervoussystemdevelopmentneuromuscularjunctiondevelopmentneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneNMDAselectiveglutamatereceptorsignalingpathwaypositiveregulationofdendriticspinemorphogenesispositiveregulationofGTPaseactivityproteinphosphorylationregulationofdendritedevelopmentregulationofmodificationofpostsynapticactincytoskeletonregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembranesocialbehavior
BAH and coiled-coil domain-containing protein 1
4.7
57
63
BAHC1BAHC1Q3UHR0Q3UHR0
Rho GTPase-activating protein 32
4.7
83
62
RHG32RHG32A7KAX9A7KAX9regulationofsmallGTPasemediatedsignaltransductionsmallGTPasemediatedsignaltransduction
Tyrosine-protein phosphatase non-receptor type 22
4.7
84
69
PTN22PTN22Q9Y2R2Q9Y2R2autophagycellularresponsetomuramyldipeptidelipidmetabolicprocesslipopolysaccharide-mediatedsignalingpathwaynegativeregulationofautophagynegativeregulationofgeneexpressionnegativeregulationofinterleukin-6productionnegativeregulationofinterleukin-8productionnegativeregulationofJUNkinaseactivitynegativeregulationofnucleotide-bindingoligomerizationdomaincontaining2signalingpathwaynegativeregulationofp38MAPKcascadenegativeregulationofTcellactivationnegativeregulationofTcellreceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionpeptidyl-tyrosinedephosphorylationphosphoanandamidedephosphorylationpositiveregulationofCD8-positivealpha-betaTcellproliferationpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofgranzymeBproductionpositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofproteinK63-linkedubiquitinationpositiveregulationoftoll-likereceptor3signalingpathwaypositiveregulationoftoll-likereceptor4signalingpathwaypositiveregulationoftoll-likereceptor7signalingpathwaypositiveregulationoftoll-likereceptor9signalingpathwaypositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIIinterferonproductionproteindephosphorylationregulationofBcellreceptorsignalingpathwayregulationofinnateimmuneresponseregulationofnaturalkillercellproliferationregulationofNIK/NF-kappaBsignalingresponsetolipopolysaccharideTcelldifferentiationTcellreceptorsignalingpathway
CCR4-NOT transcription complex subunit 11
5.0
62
69
CNO10CNO11Q9H9A5Q9UKZ1mRNAcatabolicprocessnegativeregulationoftranslationnuclear-transcribedmRNApoly(A)tailshorteningRNA-mediatedgenesilencing
Echinoderm microtubule-associated protein-like 1
4.7
63
68
EMAL1EMAL1O00423O00423braindevelopmenthematopoieticprogenitorcelldifferentiationmicrotubulecytoskeletonorganizationmitoticspindleorganizationneuroblastproliferation
Protein inturned
4.8
83
60
INTUINTUQ9ULD6Q9ULD6celldivisionciliumassemblyembryonicdigitmorphogenesisestablishmentofplanarpolarityhairfolliclemorphogenesisintraciliarytransportkeratinocytedifferentiationlimbdevelopmentmotileciliumassemblynegativeregulationofcelldivisionnegativeregulationofkeratinocyteproliferationnervoussystemdevelopmentneuraltubedevelopmentnon-motileciliumassemblypositiveregulationofsmoothenedsignalingpathwayproteinlocalizationtoorganelleregulationofciliumassemblyregulationofossificationregulationofsmoothenedsignalingpathwayroofofmouthdevelopmentsmoothenedsignalingpathwayspinalcorddorsal/ventralpatterningtonguemorphogenesisvesicle-mediatedtransport
Rho-related GTP-binding protein Rho6
4.0
60
78
RND1RND1Q92730Q92730actinfilamentorganizationcellmigrationcorticalcytoskeletonorganizationestablishmentormaintenanceofcellpolaritynegativeregulationofcelladhesionneuronremodelingregulationofactincytoskeletonorganizationregulationofcellshapesmallGTPasemediatedsignaltransduction
Sharpin
4.8
69
69
SHRPNSHRPNQ9H0F6Q9H0F6apoptoticnuclearchangesbraindevelopmentdefenseresponsetobacteriumkeratinizationmitochondrionorganizationnegativeregulationofinflammatoryresponsepositiveregulationofI-kappaBkinase/NF-kappaBsignalingproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinlinearpolyubiquitinationregulationofCD40signalingpathwayregulationoftumornecrosisfactor-mediatedsignalingpathway
Calmodulin-lysine N-methyltransferase
4.8
82
63
CMKMTCMKMTQ7Z624Q7Z624mitochondrionorganizationpeptidyl-lysinemethylationproteinmethylationregulationofrhodopsinmediatedsignalingpathway
Prolyl 3-hydroxylase OGFOD1
4.8
77
62
OGFD1OGFD1Q8N543Q8N543cellpopulationproliferationpeptidyl-prolinehydroxylationproteinhydroxylationregulationoftranslationalterminationstressgranuleassembly
Dehydrogenase/reductase SDR family member 11
4.8
77
65
DHR11DHR11Q6UWP2Q6UWP2estrogenbiosyntheticprocesssteroidbiosyntheticprocess
Exosome complex component RRP4
4.8
88
66
EXOS2EXOS2Q13868Q13868CUTcatabolicprocessexonucleolyticcatabolismofdeadenylatedmRNA"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"nuclearpolyadenylation-dependentrRNAcatabolicprocessnuclearpolyadenylation-dependenttRNAcatabolicprocess"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5""polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationofcellgrowthRNAcatabolicprocessRNAprocessingrRNAprocessing"U4snRNA3-endprocessing"
Alanine--tRNA ligase, cytoplasmic
4.8
80
64
SYACSYACP49588P49588alanyl-tRNAaminoacylationcerebellarPurkinjecelllayerdevelopmentnegativeregulationofneuronapoptoticprocessneuromuscularprocesscontrollingbalanceneuronapoptoticprocessregulationofcytoplasmictranslationalfidelitytRNAaminoacylationforproteintranslationtRNAmodificationtRNAprocessing
Uridine 5'-monophosphate synthase
4.8
91
64
UMPSUMPSP11172P11172"denovopyrimidinenucleobasebiosyntheticprocess""denovoUMPbiosyntheticprocess"cellularresponsetoxenobioticstimulusfemalepregnancylactationpyrimidinenucleobasebiosyntheticprocessUDPbiosyntheticprocessUMPbiosyntheticprocess
Interferon-induced protein with tetratricopeptide repeats 2
4.8
77
66
✔
IFIT2IFIT2P09913P09913apoptoticmitochondrialchangesdefenseresponsetovirusinnateimmuneresponsenegativeregulationofproteinbindingpositiveregulationofapoptoticprocessresponsetovirus
SH3 and cysteine-rich domain-containing protein
4.8
79
70
STACSTACQ99469Q99469cellularresponsetoheatpositiveregulationofcationchannelactivitypositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofvoltage-gatedcalciumchannelactivitysignaltransductionskeletalmusclecontraction
Liprin-alpha-2
4.8
48
73
LIPA2LIPA2O75334O75334cell-matrixadhesiondensecoregranulecytoskeletaltransportregulationofdendriticspinedevelopmentregulationofdendriticspinemorphogenesissynapseorganization
Replication factor C subunit 1
4.8
80
64
✔
RFC1RFC1P35251P35251DNArepairDNA-templatedDNAreplicationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptiontelomeremaintenanceviatelomerase
Influenza virus NS1A-binding protein
4.8
62
76
✔
NS1BPNS1BPQ9Y6Y0Q9Y6Y0intrinsicapoptoticsignalingpathwaynegativeregulationofintrinsicapoptoticsignalingpathwaynegativeregulationofproteinubiquitinationresponsetovirusRNAsplicingtranscriptionbyRNApolymeraseIII
Tumor necrosis factor receptor superfamily member 12A
4.9
49
74
TNR12TNR12Q9NP84Q9NP84angiogenesisapoptoticprocesscelladhesioncelldifferentiationpositiveregulationofapoptoticprocesspositiveregulationofextrinsicapoptoticsignalingpathwayregulationofwoundhealing
Nucleoside diphosphate kinase A
2.0
50
85
NDKANDKAP15531P15531celldifferentiationCTPbiosyntheticprocessendocytosisGTPbiosyntheticprocesslactationnegativeregulationofcellpopulationproliferationnervoussystemdevelopmentnucleosidediphosphatephosphorylationpositiveregulationofDNAbindingpositiveregulationofepithelialcellproliferationregulationofapoptoticprocessUTPbiosyntheticprocess
Protein FosB
3.5
nan
81
FOSBFOSBP53539P53539cellularresponsetocalciumioncellularresponsetohormonestimulusfemalepregnancynegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetocAMPresponsetocorticosteroneresponsetomechanicalstimulusresponsetomorphineresponsetoprogesteroneresponsetoxenobioticstimulustranscriptionbyRNApolymeraseII
E3 ubiquitin-protein ligase CHIP
4.8
81
54
CHIPCHIPQ9UNE7Q9UNE7cellularresponsetoheatcellularresponsetohypoxiacellularresponsetomisfoldedproteinchaperone-mediatedautophagyDNArepairendoplasmicreticulumunfoldedproteinresponseERBB2signalingpathwaynegativeregulationofproteinbindingnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofchaperone-mediatedproteincomplexassemblypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationpositiveregulationofproteolysispositiveregulationofubiquitin-proteintransferaseactivityproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinK63-linkedubiquitinationproteinmaturationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsproteinubiquitinationregulationofglucocorticoidmetabolicprocessregulationofproteinstabilityresponsetoischemiaubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocessubiquitin-dependentSMADproteincatabolicprocess
Mitogen-activated protein kinase kinase kinase 5
4.8
71
67
M3K5M3K5Q99683Q99683apoptoticsignalingpathwaycellularresponsetoaminoacidstarvationcellularresponsetohydrogenperoxidecellularresponsetoreactivenitrogenspeciescellularresponsetotumornecrosisfactorcellularsenescenceendothelialcellapoptoticprocessinnateimmuneresponseintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressintrinsicapoptoticsignalingpathwayinresponsetooxidativestressJNKcascadeMAPKcascadep38MAPKcascadepositiveregulationofapoptoticprocesspositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofmyoblastdifferentiationpositiveregulationofneurondeathpositiveregulationofp38MAPKcascadepositiveregulationofproteinkinaseactivitypositiveregulationofvascularassociatedsmoothmusclecellproliferationprogrammednecroticcelldeathproteinphosphorylationresponsetoendoplasmicreticulumstressresponsetoischemiastress-activatedMAPKcascadewoundhealing
Speedy protein A
4.8
35
73
SPDYASPDYAQ5MJ70Q5MJ70cellularresponsetoDNAdamagestimulusG1/Stransitionofmitoticcellcyclemalemeioticnucleardivisionpositiveregulationofcellpopulationproliferationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofproteinkinaseactivity
Ankyrin repeat and SOCS box protein 11
4.8
87
69
ASB11ASB11Q8WXH4Q8WXH4intracellularsignaltransductionpositiveregulationofproteincatabolicprocessproteinubiquitination
Monocarboxylate transporter 1
4.8
54
70
MOT1MOT1P53985P53985behavioralresponsetonutrientcarboxylicacidtransmembranetransportcellularresponsetoorganiccycliccompoundcentrosomecycleglucosehomeostasislipidmetabolicprocessmevalonatetransportmonocarboxylicacidtransportplasmamembranelactatetransportpyruvatecatabolicprocesspyruvatetransmembranetransportregulationofinsulinsecretionresponsetofoodsuccinatetransmembranetransporttransportacrossblood-brainbarrier
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
4.8
94
60
IDH3GIDH3GP51553P51553carbohydratemetabolicprocessisocitratemetabolicprocesstricarboxylicacidcycle
Protein SCO1 homolog, mitochondrial
4.8
59
74
SCO1SCO1O75880O75880cellularcopperionhomeostasismitochondrialcytochromecoxidaseassembly
Receptor-type tyrosine-protein phosphatase beta
4.8
64
71
PTPRBPTPRBQ3MIV7Q3MIV7angiogenesisdephosphorylationglialcellmigrationpeptidyl-tyrosinedephosphorylationinvolvedininactivationofproteinkinaseactivityphosphate-containingcompoundmetabolicprocessproteindephosphorylation
Tyrosine-protein phosphatase non-receptor type 12
4.8
68
67
PTN12PTN12Q05209Q05209cellularresponsetoepidermalgrowthfactorstimulusnegativeregulationofERBBsignalingpathwaynegativeregulationofplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypeptidyl-tyrosinedephosphorylationproteindephosphorylationregulationofepidermalgrowthfactorreceptorsignalingpathwaytissueregeneration
Cysteine desulfurase
4.8
75
77
NFS1ISCUQ9Y697Q9H1K12Fe-2Sclusterassembly4Fe-4Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocessmolybdopterincofactormetabolicprocesscellularironionhomeostasisironionhomeostasisnegativeregulationofironionimportacrossplasmamembranepositiveregulationofaconitatehydrataseactivitypositiveregulationofmitochondrialelectrontransportNADHtoubiquinone
Gamma-crystallin C
4.9
58
74
CRGCCRGCQ61597Q61597camera-typeeyedevelopmenteyedevelopmentlensdevelopmentincamera-typeeyevisualperception
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
4.8
90
64
IDH3AIDH3AP50213P50213carbohydratemetabolicprocessisocitratemetabolicprocesstricarboxylicacidcycle
Isoform A of Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
4.8
85
59
IDH3BIDH3BO43837-2O43837-2
Protein arginine N-methyltransferase 7
3.9
52
78
ANM7ANM7Q922X9Q922X9celldifferentiationhistonemethylationpeptidyl-argininemethylationregulationofgeneexpressionbygenomicimprintingspliceosomalsnRNPassembly
PREX1
4.8
95
58
A0A2X0SFH1A0A2X0SFH1A0A2X0SFH1A0A2X0SFH1intracellularsignaltransductionregulationofcatalyticactivityregulationofsmallGTPasemediatedsignaltransduction
Nck-associated protein 1
4.8
85
61
NCKP1NCKP1Q9Y2A7Q9Y2A7apoptoticprocesscellmigrationcellmorphogenesiscellprojectionassemblycentralnervoussystemdevelopmentcorticalactincytoskeletonorganizationneuronprojectionmorphogenesispositiveregulationofactinfilamentpolymerizationpositiveregulationofArp2/3complex-mediatedactinnucleationpositiveregulationoflamellipodiumassemblyRacproteinsignaltransduction
cGMP-gated cation channel alpha-1
4.8
73
64
CNGA1CNGA1P29973P29973cationtransmembranetransportresponsetostimulusvisualperception
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
4.8
84
66
WRNWRNQ14191Q14191agingbase-excisionrepairbraindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetostarvationcellularsenescenceDNAduplexunwindingDNAmetabolicprocessDNArecombinationDNArepairDNAreplicationDNAsynthesisinvolvedinDNArepairDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationG-quadruplexDNAunwindingmulticellularorganismagingpositiveregulationofhydrolaseactivitypositiveregulationofstrandinvasionproteinlocalizationtonucleolusregulationofgrowthratereplicationforkprocessingreplicativesenescenceresponsetooxidativestressresponsetoUV-Ct-circleformationtelomeremaintenancetelomeremaintenanceviasemi-conservativereplicationtelomericD-loopdisassembly
N-acylneuraminate cytidylyltransferase
4.8
94
60
NEUANEUAQ99KK2Q99KK2CMP-N-acetylneuraminatebiosyntheticprocessN-acetylneuraminatemetabolicprocess
Exosome complex component RRP42
4.9
62
71
EXOS7EXOS7Q15024Q15024exonucleolyticcatabolismofdeadenylatedmRNA"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"nuclearmRNAsurveillancenuclearpolyadenylation-dependentmRNAcatabolicprocessnuclearpolyadenylation-dependentrRNAcatabolicprocessnuclearpolyadenylation-dependenttRNAcatabolicprocess"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5"RNAcatabolicprocessRNAprocessingrRNAcatabolicprocessrRNAprocessing"U1snRNA3-endprocessing""U4snRNA3-endprocessing""U5snRNA3-endprocessing"
Ribonucleoside-diphosphate reductase subunit M2
4.9
74
63
RIR2RIR2P31350P31350"2-deoxyribonucleotidebiosyntheticprocess"blastocystdevelopmentdeoxyribonucleotidebiosyntheticprocessDNAreplicationpositiveregulationofG1/Stransitionofmitoticcellcycleproteinheterotetramerizationribonucleosidediphosphatemetabolicprocess
Serine/threonine-protein kinase Chk2
4.9
77
63
CHK2CHK2O96017O96017celldivisioncellularresponsetobisphenolAcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetoxenobioticstimulusDNAdamagecheckpointsignalingDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatordouble-strandbreakrepairG2/MtransitionofmitoticcellcycleintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatormitoticDNAdamagecheckpointsignalingmitoticintra-SDNAdamagecheckpointsignalingmitoticspindleassemblynegativeregulationofDNAdamagecheckpointpeptidyl-serinephosphorylationpositiveregulationofanoikispositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinphosphorylationproteinautophosphorylationproteincatabolicprocessproteinphosphorylationproteinstabilizationregulationofDNA-templatedtranscriptionregulationofproteincatabolicprocessregulationofsignaltransductionbyp53classmediatorreplicativesenescenceresponsetoglycosidesignaltransductioninresponsetoDNAdamagethymocyteapoptoticprocess
Mitogen-activated protein kinase kinase kinase 12
4.9
75
63
M3K12M3K12Q12852Q12852intracellularsignaltransductionJNKcascadenegativeregulationofmotorneuronapoptoticprocesspeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofJUNkinaseactivitypositiveregulationofproteinkinaseactivitypost-translationalproteinmodificationproteinautophosphorylationproteinphosphorylation
Cullin-5
4.9
69
68
CUL5CUL5Q93034Q93034ERBB2signalingpathwayG1/StransitionofmitoticcellcycleintrinsicapoptoticsignalingpathwayproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
CTP synthase 2
4.9
91
62
✔
PYRG2PYRG2Q9NRF8Q9NRF8"denovoCTPbiosyntheticprocess"CTPbiosyntheticprocessglutaminemetabolicprocesspyrimidinenucleobasebiosyntheticprocesspyrimidinenucleotidemetabolicprocess
Tyrosine-protein phosphatase non-receptor type 6
4.9
70
65
PTN6PTN6P29350P29350abortivemitoticcellcycleBcellreceptorsignalingpathwaycelldifferentiationcytokine-mediatedsignalingpathwayepididymisdevelopmentGprotein-coupledreceptorsignalingpathwayhematopoieticprogenitorcelldifferentiationintracellularsignaltransductionMAPKcascademegakaryocytedevelopmentmitoticcellcyclenaturalkillercellmediatedcytotoxicitynegativeregulationofcellpopulationproliferationnegativeregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinnegativeregulationofinterleukin-6productionnegativeregulationofMAPkinaseactivitynegativeregulationofmastcellactivationinvolvedinimmuneresponsenegativeregulationofpeptidyl-tyrosinephosphorylationnegativeregulationofTcellproliferationnegativeregulationofTcellreceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionpeptidyl-tyrosinedephosphorylationpeptidyl-tyrosinephosphorylationplateletaggregationplateletformationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellpopulationproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingproteindephosphorylationregulationofapoptoticprocessregulationofBcelldifferentiationregulationofERK1andERK2cascaderegulationofG1/StransitionofmitoticcellcycleregulationofreleaseofsequesteredcalciumionintocytosolregulationoftypeIinterferon-mediatedsignalingpathwayTcellcostimulationTcellproliferationTcellreceptorsignalingpathway
Gasdermin-D
4.9
63
75
GSDMDGSDMDP57764P57764cellularresponsetoextracellularstimulusdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminflammatoryresponseinnateimmuneresponseporecomplexassemblypositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-1productionpositiveregulationofinterleukin-18productionproteinhomooligomerizationpyroptosis
Ankyrin repeat and SOCS box protein 9
4.9
83
66
ASB9ASB9A8K8A5A8K8A5intracellularsignaltransductionpositiveregulationofproteincatabolicprocessproteinubiquitination
Kynurenine--oxoglutarate transaminase 1
4.9
84
63
KAT1KAT1Q16773Q16773biosyntheticprocesskynureninemetabolicprocessL-kynureninecatabolicprocessresponsetobacterium
Indoleamine 2,3-dioxygenase 1
4.9
66
67
I23O1I23O1P14902P14902"denovoNADbiosyntheticprocessfromtryptophan"femalepregnancyinflammatoryresponsekynurenicacidbiosyntheticprocessmulticellularorganismalresponsetostressnegativeregulationofinterleukin-10productionnegativeregulationofTcellapoptoticprocessnegativeregulationofTcellproliferationpositiveregulationofchronicinflammatoryresponsepositiveregulationofinterleukin-12productionpositiveregulationofTcellapoptoticprocesspositiveregulationofTcelltoleranceinductionpositiveregulationoftype2immuneresponseresponsetolipopolysaccharideswimmingbehaviorTcellproliferationtryptophancatabolicprocesstryptophancatabolicprocesstokynurenine
Alpha-aminoadipic semialdehyde dehydrogenase
4.9
107
56
AL7A1AL7A1P49419P49419cellularaldehydemetabolicprocesscholinecatabolicprocessglycinebetainebiosyntheticprocessfromcholinesensoryperceptionofsound
Fuzzy planar cell polarity protein
4.9
79
63
E9QL29E9QL29E9QL29E9QL29negativeregulationofcellmigrationneuraltubeclosurenon-motileciliumassemblypositiveregulationofciliumassemblyvesicle-mediatedtransport
Cystathionine beta-synthase
4.9
59
69
CBSCBSP35520P35520bloodvesseldiametermaintenancebloodvesselremodelingcartilagedevelopmentinvolvedinendochondralbonemorphogenesiscellularresponsetohypoxiacerebellummorphogenesiscysteinebiosyntheticprocesscysteinebiosyntheticprocessfromserinecysteinebiosyntheticprocessviacystathionineDNAprotectionendochondralossificationhomocysteinecatabolicprocesshomocysteinemetabolicprocesshydrogensulfidebiosyntheticprocessL-cysteinecatabolicprocessL-serinecatabolicprocessL-serinemetabolicprocessmaternalprocessinvolvedinfemalepregnancynegativeregulationofapoptoticprocessregulationofJUNkinaseactivityregulationofnitricoxidemediatedsignaltransductionresponsetofolicacidsuperoxidemetabolicprocesstranssulfuration
Probable ATP-dependent RNA helicase DDX20
4.9
71
60
DDX20DDX20Q9UHI6Q9UHI6negativeregulationofcellpopulationproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIoogenesispositiveregulationofapoptoticprocessregulationofsteroidbiosyntheticprocessRNAprocessingspliceosomalsnRNPassemblyspliceosomaltri-snRNPcomplexassembly
Inositol monophosphatase 1
4.9
66
66
✔
IMPA1IMPA1P29218P29218inositolbiosyntheticprocessinositolmetabolicprocessinositolphosphatedephosphorylationphosphate-containingcompoundmetabolicprocessphosphatidylinositolbiosyntheticprocessphosphatidylinositolphosphatebiosyntheticprocesssignaltransduction
N-terminal Xaa-Pro-Lys N-methyltransferase 2
4.9
87
60
NTM1BNTM1BQ5VVY1Q5VVY1N-terminalproteinaminoacidmethylation
RNA 5'-monophosphate methyltransferase
4.7
80
64
BN3D2BN3D2Q7Z5W3Q7Z5W3miRNAmetabolicprocessnegativeregulationofpre-miRNAprocessingpre-miRNAprocessingRNAmethylationtRNAmethylation
Destrin
5.9
59
57
✔
DESTDESTP60982P60982actinfilamentdepolymerizationactinfilamentfragmentationactinfilamentseveringpositiveregulationofactinfilamentdepolymerization
Cytosolic acyl coenzyme A thioester hydrolase
4.9
79
70
BACHBACHQ91V12Q91V12acyl-CoAmetabolicprocesscoenzymeAbiosyntheticprocessfattyacidcatabolicprocessfattyacidmetabolicprocesslong-chainfatty-acyl-CoAcatabolicprocessmedium-chainfattyacidbiosyntheticprocessmedium-chainfatty-acyl-CoAcatabolicprocesspalmiticacidbiosyntheticprocess
Eukaryotic translation initiation factor 2A
4.9
79
68
EIF2AEIF2AQ9BY44Q9BY44positiveregulationofsignaltransductionproteinphosphorylationregulationoftranslationresponsetoaminoacidstarvationribosomeassemblySREBPsignalingpathway
Serine/threonine-protein kinase mTOR
4.9
58
68
MTORMTORP42345P42345"denovopyrimidinenucleobasebiosyntheticprocess"activationofproteinkinaseBactivityanoikisbehavioralresponsetopaincalcineurin-NFATsignalingcascadecardiacmusclecelldevelopmentcardiacmusclecontractioncellularresponsetoaminoacidstarvationcellularresponsetoaminoacidstimuluscellularresponsetoDNAdamagestimuluscellularresponsetohypoxiacellularresponsetoleucinecellularresponsetoleucinestarvationcellularresponsetonutrientlevelscellularresponsetoosmoticstresscellularresponsetostarvationcytoskeletonorganizationenergyreservemetabolicprocessgermcelldevelopmentheartmorphogenesisheartvalvemorphogenesisinflammatoryresponselysosomeorganizationmacroautophagymulticellularorganismgrowthnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofcellsizenegativeregulationofmacroautophagyneuronalactionpotentialnucleuslocalizationoligodendrocytedifferentiationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationphosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellgrowthpositiveregulationofcytoplasmictranslationalinitiationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofkeratinocytemigrationpositiveregulationoflamellipodiumassemblypositiveregulationoflipidbiosyntheticprocesspositiveregulationofmyotubedifferentiationpositiveregulationofoligodendrocytedifferentiationpositiveregulationofpentose-phosphateshuntpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseIpositiveregulationoftranslationpositiveregulationofwoundhealingspreadingofepidermalcellspost-embryonicdevelopmentproteinautophosphorylationproteincatabolicprocessproteinphosphorylationregulationofactincytoskeletonorganizationregulationofcellgrowthregulationofcellsizeregulationofcellularresponsetoheatregulationofcircadianrhythmregulationofGTPaseactivityregulationoflocomotorrhythmregulationofmacroautophagyregulationofmembranepermeabilityregulationofmyelinationregulationofosteoclastdifferentiationregulationofproteinkinaseBsignalingregulationofsignaltransductionbyp53classmediatorresponsetoaminoacidresponsetoheatresponsetoinsulinresponsetonutrientresponsetonutrientlevelsrhythmicprocessruffleorganizationT-helper1celllineagecommitmentTORsignalingTORC1signalingvoluntarymusculoskeletalmovement
Methylosome protein 50
6.5
nan
60
MEP50MEP50Q9BQA1Q9BQA1epithelialcellproliferationinvolvedinprostateglanddevelopmenthistoneH4-R3methylationnegativeregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentoocyteaxisspecificationpositiveregulationofcellpopulationproliferationpositiveregulationofmRNAsplicingviaspliceosomeregulationoftranscriptionbyRNApolymeraseIIsecretorycolumnalluminarepithelialcelldifferentiationinvolvedinprostateglandularacinusdevelopmentspliceosomalsnRNPassembly
Inosine triphosphate pyrophosphatase
4.9
76
61
ITPAITPAQ9BY32Q9BY32chromosomeorganizationdeoxyribonucleosidetriphosphatecatabolicprocessITPcatabolicprocessnucleosidetriphosphatecatabolicprocess
Ectodysplasin-A
4.9
93
59
EDAEDAQ92838Q92838animalorgandevelopmentcanonicalWntsignalingpathwaycelldifferentiationcell-matrixadhesioncytokine-mediatedsignalingpathwaygeneexpressionhairfollicleplacodeformationimmuneresponseodontogenesisofdentin-containingtoothpigmentationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingregulationofNIK/NF-kappaBsignalingsalivaryglandcavitationtracheaglanddevelopment
Protein-glutamine gamma-glutamyltransferase E
4.9
57
66
TGM3TGM3Q08188Q08188cellenvelopeorganizationhairfolliclemorphogenesiskeratinizationkeratinocytedifferentiationpeptidecross-linkingproteinmodificationprocess
Interferon regulatory factor 3
4.9
66
68
IRF3IRF3Q14653Q14653apoptoticprocesscellularresponsetoDNAdamagestimuluscellularresponsetoexogenousdsRNAcellularresponsetovirusdefenseresponsetovirusimmunesystemprocesslipopolysaccharide-mediatedsignalingpathwaymacrophageapoptoticprocessMDA-5signalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayprogrammednecroticcelldeathregulationofapoptoticprocessregulationofinflammatoryresponseregulationoftranscriptionbyRNApolymeraseIITRIF-dependenttoll-likereceptorsignalingpathwaytypeIinterferon-mediatedsignalingpathway
Vacuolar protein sorting-associated protein 35
4.9
87
63
VPS35VPS35Q96QK1Q96QK1endocyticrecyclingintracellularproteintransportlysosomeorganizationmitochondrialfragmentationinvolvedinapoptoticprocessmitochondriontolysosometransportmodulationofchemicalsynaptictransmissionnegativeregulationofcelldeathnegativeregulationofgeneexpressionnegativeregulationofinflammatoryresponsenegativeregulationoflateendosometolysosometransportnegativeregulationoflysosomalproteincatabolicprocessnegativeregulationofneurondeathnegativeregulationofproteinhomooligomerizationnegativeregulationofproteinlocalizationneurotransmitterreceptortransportendosometoplasmamembraneneurotransmitterreceptortransportendosometopostsynapticmembranepositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofdopaminebiosyntheticprocesspositiveregulationofdopaminereceptorsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationoflocomotioninvolvedinlocomotorybehaviorpositiveregulationofmitochondrialfissionpositiveregulationofproteincatabolicprocesspositiveregulationofWntproteinsecretionproteindestabilizationproteinlocalizationtoendosomeregulationofdendriticspinemaintenanceregulationofmacroautophagyregulationofmitochondrionorganizationregulationofpostsynapseassemblyregulationofpresynapseassemblyregulationofproteinmetabolicprocessregulationofproteinstabilityregulationofsynapsematurationregulationofterminalbuttonorganizationretrogradetransportendosometoGolgitranscytosisvesicle-mediatedtransportinsynapsevoluntarymusculoskeletalmovementWntsignalingpathway
ER membrane protein complex subunit 10
4.9
62
68
EMC10EMC10Q5UCC4Q5UCC4angiogenesispositiveregulationofangiogenesispositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationproteininsertionintoERmembranebystop-transfermembrane-anchorsequencetail-anchoredmembraneproteininsertionintoERmembrane
Eukaryotic translation initiation factor 3 subunit C
4.9
69
70
EIF3CRS27Q99613P42677formationofcytoplasmictranslationinitiationcomplexpositiveregulationofmRNAbindingpositiveregulationoftranslationtranslationalinitiationcytoplasmictranslationribosomalsmallsubunitassemblyrRNAprocessingtranslation
Mothers against decapentaplegic homolog 1
4.9
72
68
SMAD1SMAD1Q15797Q15797anatomicalstructuremorphogenesisBMPsignalingpathwaybonedevelopmentcardiacconductionsystemdevelopmentcardiacmusclecellproliferationcartilagedevelopmentcelldifferentiationcellularresponsetoorganiccycliccompoundDNA-templatedtranscriptionembryonicpatternspecificationgametegenerationhindbraindevelopmenthomeostaticprocessinflammatoryresponseMAPKcascademesodermalcellfatecommitmentmidbraindevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofmusclecelldifferentiationosteoblastdifferentiationosteoblastfatecommitmentpositiveregulationofcartilagedevelopmentpositiveregulationofgeneexpressionpositiveregulationofmiRNAtranscriptionpositiveregulationofosteoblastdifferentiationpositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimulusprimarymiRNAprocessingproteinphosphorylationsignaltransductionSMADproteincomplexassemblySMADproteinsignaltransductiontranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopment
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
4.9
76
72
NADCNADCQ15274Q15274NADbiosyntheticprocessNADmetabolicprocessquinolinatecatabolicprocess
Mitochondrial Rho GTPase 1
4.9
91
61
MIRO1MIRO1Q8IXI2Q8IXI2cellularhomeostasismitochondrialoutermembranepermeabilizationmitochondrionorganizationmitochondriontransportalongmicrotubuleregulationofmitochondrionorganizationsmallGTPasemediatedsignaltransduction
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
4.9
97
57
A0A4X1SZP7A0A287BG40A0A4X1SZP7A0A287BG40mitochondrialATPsynthesiscoupledelectrontransportcardiacmuscletissuedevelopmentmitochondrialelectrontransportNADHtoubiquinonenervoussystemdevelopment
Proteasome activator complex subunit 4
4.9
77
62
PSME4PSME4Q14997Q14997cellularresponsetoDNAdamagestimulusDNArepairproteasomalubiquitin-independentproteincatabolicprocessspermDNAcondensation
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A
4.9
72
69
ERF3AERF3AP15170P15170G1/Stransitionofmitoticcellcyclenuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecayproteinmethylationregulationoftranslationalterminationtranslationtranslationaltermination
Protein MIS12 homolog
4.9
54
72
✔
MIS12PMF1Q9H081Q6P1K2attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionchromosomesegregationkinetochoreassemblymitoticsisterchromatidsegregationproteinlocalizationtokinetochoretranscriptionbyRNApolymeraseII
Gamma-aminobutyric acid receptor subunit alpha-5
4.9
85
62
GBRA5GBRA5P31644P31644associativelearningbehavioralfearresponsebraindevelopmentchemicalsynaptictransmissionchloridetransmembranetransportcochleadevelopmentgamma-aminobutyricacidsignalingpathwayinnerearreceptorcelldevelopmentinnervationiontransmembranetransportnegativeregulationofneuronapoptoticprocessnervoussystemprocessregulationofmembranepotentialregulationofpostsynapticmembranepotentialsensoryperceptionofsoundsignaltransductionsynaptictransmissionGABAergic
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
4.9
73
73
V9HWJ5V9HWJ5V9HWJ5V9HWJ5NADbiosyntheticprocess
N-terminal Xaa-Pro-Lys N-methyltransferase 1
4.9
88
60
✔
NTM1ANTM1AQ9BV86Q9BV86chromosomesegregationhistonemethylationN-terminalpeptidyl-alaninemethylationN-terminalpeptidyl-alaninetrimethylationN-terminalpeptidyl-glycinemethylationN-terminalpeptidyl-prolinedimethylationN-terminalpeptidyl-prolinemethylationN-terminalpeptidyl-serinedimethylationN-terminalpeptidyl-serinemethylationN-terminalpeptidyl-serinetrimethylationN-terminalproteinaminoacidmethylationspindleorganization
MAP kinase-activated protein kinase 3
4.9
67
70
MAPK3MAPK3Q16644Q16644intracellularsignaltransductionmacropinocytosispeptidyl-serinephosphorylationproteinautophosphorylationresponsetocytokineresponsetolipopolysaccharidesignaltransductiontoll-likereceptorsignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
Mitogen-activated protein kinase kinase kinase kinase 4
4.9
90
60
M4K4M4K4O95819O95819intracellularsignaltransductionMAPKcascadenegativeregulationofapoptoticprocessnegativeregulationofcell-matrixadhesionneuronprojectionmorphogenesispositiveregulationofARFproteinsignaltransductionpositiveregulationofcellmigrationpositiveregulationoffocaladhesionassemblypositiveregulationoffocaladhesiondisassemblypositiveregulationofGTPaseactivitypositiveregulationofkeratinocytemigrationproteinphosphorylationregulationofJNKcascaderegulationofMAPKcascade
Cleavage and polyadenylation specificity factor subunit 3
4.9
92
57
CPSF3CPSF3Q9UKF6Q9UKF6"mRNA3-endprocessing""mRNA3-endprocessingbystem-loopbindingandcleavage"mRNAcleavagemRNApolyadenylationpositiveregulationofG1/Stransitionofmitoticcellcycle
Two pore channel protein 2
2.0
36
88
TPC2TPC2Q8NHX9Q8NHX9calcium-mediatedsignalingcellularcalciumionhomeostasisendocytosisinvolvedinviralentryintohostcellendosometolysosometransportoflow-densitylipoproteinparticleintracellularpHreductioniontransmembranetransportlysosomeorganizationnegativeregulationofdevelopmentalpigmentationreceptor-mediatedendocytosisofvirusbyhostcellregulationofautophagyregulationofexocytosisregulationofiontransmembranetransportresponsetovitaminDsmoothmusclecontractionsodiumiontransmembranetransport
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
5.0
68
65
P2R3BP2R3BQ9Y5P8Q9Y5P8proteindephosphorylationregulationofcellcycle
Catenin alpha-2
5.0
61
70
CTNA2CTNA2Q61301Q61301axonogenesisbrainmorphogenesiscellmigrationcell-celladhesiondendritemorphogenesismodificationofpostsynapticactincytoskeletonnegativeregulationofArp2/3complex-mediatedactinnucleationprepulseinhibitionradialgliaguidedmigrationofPurkinjecellregulationofneuronmigrationregulationofneuronprojectiondevelopmentregulationofsynapsestructuralplasticity
Tripartite motif-containing protein 45
5.0
76
72
TRI45TRI45Q9H8W5Q9H8W5bonedevelopmentpositiveregulationofDNA-templatedtranscription
Phosphoinositide 3-kinase adapter protein 1
5.0
54
67
BCAPBCAPQ6ZUJ8Q6ZUJ8positiveregulationofphosphatidylinositol3-kinasesignalingregulationofinflammatoryresponsetoll-likereceptor2signalingpathwaytoll-likereceptor4signalingpathwaytoll-likereceptor7signalingpathwaytoll-likereceptor9signalingpathway
CLIP-associating protein 1
5.0
87
62
✔
CLAP1CLAP1Q7Z460Q7Z460astralmicrotubuleorganizationcelldivisionestablishmentofepithelialcellpolarityestablishmentofmitoticspindlelocalizationestablishmentofspindleorientationestablishmentormaintenanceofcellpolarityexitfrommitosisGolgiorganizationmicrotubuleanchoringmicrotubulebundleformationmicrotubulecytoskeletonorganizationmicrotubulenucleationmicrotubuleorganizingcenterorganizationmitoticspindleassemblymitoticspindleorganizationnegativeregulationofmicrotubuledepolymerizationnegativeregulationofmicrotubulepolymerizationordepolymerizationnegativeregulationofstressfiberassemblynegativeregulationofwoundhealingspreadingofepidermalcellspositiveregulationofbasementmembraneassemblyinvolvedinembryonicbodymorphogenesispositiveregulationofepithelialcellmigrationpositiveregulationofexocytosispositiveregulationofextracellularmatrixdisassemblypositiveregulationofmicrotubulepolymerizationregulationofepithelialtomesenchymaltransitionregulationoffocaladhesionassemblyregulationofgastrulationregulationofmicrotubulecytoskeletonorganizationvesicletargeting
Transient receptor potential cation channel subfamily V member 3
6.1
41
68
TRPV3TRPV3Q8K424Q8K424calciumionimportacrossplasmamembranenegativeregulationofhaircyclepositiveregulationofcalciumionimportresponsetoheatresponsetotemperaturestimulus
SMC5-SMC6 complex localization factor protein 2
5.0
65
69
SLF2SLF2Q8IX21Q8IX21cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofdouble-strandbreakrepairpositiveregulationofmaintenanceofmitoticsisterchromatidcohesionpositiveregulationofprotein-containingcomplexassemblyproteinlocalizationtositeofdouble-strandbreakproteinsumoylationregulationoftelomeremaintenance
Dihydropyrimidinase
5.0
85
61
DPYSDPYSQ14117Q14117CMPcatabolicprocessdCMPcatabolicprocessdUMPcatabolicprocesspyrimidinenucleobasecatabolicprocessthyminecatabolicprocessUMPcatabolicprocessuracilcatabolicprocess
Protein fuzzy homolog
5.0
83
54
FUZZYFUZZYQ9BT04Q9BT04ciliumassemblyembryonicbodymorphogenesisembryonicskeletalsystemmorphogenesisestablishmentofplanarpolarityhairfollicledevelopmentintraciliarytransportnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastgrowthfactorreceptorsignalingpathwayinvolvedinneuralplateanterior/posteriorpatternformationnegativeregulationofneuralcrestformationneuraltubeclosureneuraltubedevelopmentnon-motileciliumassemblypositiveregulationofciliumassemblyproteintransportregulationofciliumassemblyregulationofsmoothenedsignalingpathwayvesicle-mediatedtransport
ATP-dependent RNA helicase DHX8
5.6
57
65
DHX8DHX8Q14562Q14562mRNAsplicingviaspliceosomeRNAprocessingRNAsplicingspliceosomalcomplexdisassembly
Peptidyl-prolyl cis-trans isomerase H
5.0
72
62
PPIHPPIHO43447O43447mRNAsplicingviaspliceosomepositiveregulationofviralgenomereplicationproteinfoldingproteinpeptidyl-prolylisomerizationprotein-containingcomplexassembly
Regulator of G-protein signaling 16
5.0
73
62
RGS16RGS16O15492O15492Gprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionpositiveregulationofGTPaseactivityregulationofGprotein-coupledreceptorsignalingpathwayvisualperception
Platelet-activating factor acetylhydrolase IB subunit alpha1
5.0
66
64
✔
PA1B3PA1B3Q29460Q29460braindevelopmentlipidcatabolicprocessspermatogenesis
NADPH oxidase activator 1
5.0
56
59
NOXA1NOXA1Q86UR1Q86UR1regulationofhydrogenperoxidemetabolicprocessregulationofrespiratoryburstsuperoxideaniongenerationsuperoxidemetabolicprocess
BLM protein
5.0
77
58
Q3B7X0Q3B7X0Q3B7X0Q3B7X0DNAreplication
Tubulin beta-2B chain
5.0
79
58
✔
TBB2BTBB2BQ9BVA1Q9BVA1cerebralcortexdevelopmentembryonicbraindevelopmentmicrotubulecytoskeletonorganizationmicrotubule-basedprocessmitoticcellcyclemodulationofchemicalsynaptictransmissionneuronmigrationpositiveregulationofaxonguidance
Rho-related GTP-binding protein RhoC
5.0
91
54
RHOCRHOCP08134P08134actinfilamentorganizationapicaljunctionassemblycellmigrationcorticalcytoskeletonorganizationestablishmentormaintenanceofcellpolaritymitoticcytokinesispositiveregulationofcellmigrationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationoflipaseactivitypositiveregulationofprotein-containingcomplexassemblypositiveregulationofstressfiberassemblyregulationofactincytoskeletonorganizationregulationofcellshapeskeletalmusclesatellitecellmigrationsmallGTPasemediatedsignaltransductionwoundhealingspreadingofcells
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
5.0
66
69
G5E814G5E814G5E814G5E814mitochondrialrespiratorychaincomplexIassembly
Prolyl endopeptidase
2.0
72
82
✔
PPCEPPCEP23687P23687proteolysis
Ribonucleases P/MRP protein subunit POP1
5.0
66
65
POP1POP1Q99575Q99575RNAphosphodiesterbondhydrolysisendonucleolytic"tRNA5-leaderremoval"tRNAcatabolicprocesstRNAprocessing
Dopa decarboxylase (Aromatic L-amino acid decarboxylase)
6.2
68
55
Q53Y41Q53Y41Q53Y41Q53Y41aminoacidmetabolicprocesscatecholaminebiosyntheticprocess
Importin-4
5.0
66
59
IPO4IPO4Q8TEX9Q8TEX9proteinimportintonucleusproteinlocalizationtonucleus
Clathrin heavy chain
5.8
76
61
C0MHR2C0MHR2C0MHR2C0MHR2clathrincoatassemblyintracellularproteintransportmitoticcellcyclereceptor-mediatedendocytosis
Caspase-9
5.0
79
54
CASP9CASP9P55211P55211activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecagingapoptoticprocesscellularresponsetodexamethasonestimuluscellularresponsetoDNAdamagestimuluscellularresponsetoUVepithelialcellapoptoticprocessfibroblastapoptoticprocessglialcellapoptoticprocessintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagekidneydevelopmentleukocyteapoptoticprocessneuronapoptoticprocessplateletformationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessregulationofresponsetoDNAdamagestimulusresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoischemiaresponsetolipopolysaccharidesignaltransductioninresponsetoDNAdamage
Mitochondrial Rho GTPase 2
5.0
92
51
MIRO2MIRO2Q8IXI1Q8IXI1cellularhomeostasismitochondrialoutermembranepermeabilizationmitochondrionorganizationmitochondriontransportalongmicrotubuleregulationofmitochondrionorganizationsmallGTPasemediatedsignaltransduction
Sorcin
5.0
77
53
✔
SORCNSORCNP30626P30626actionpotentialcalciumiontransportcytoplasmicsequesteringoftranscriptionfactorheartdevelopmentintracellularsequesteringofironionmuscleorgandevelopmentnegativeregulationofcardiacmusclecontractionnegativeregulationofheartratenegativeregulationofryanodine-sensitivecalcium-releasechannelactivitynegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofreleaseofsequesteredcalciumionintocytosolregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcellcommunicationbyelectricalcouplingregulationofcellcommunicationbyelectricalcouplinginvolvedincardiacconductionregulationofheartcontractionregulationofhighvoltage-gatedcalciumchannelactivityregulationofrelaxationofmuscleregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumregulationofstriatedmusclecontractionsignaltransduction
STE20/SPS1-related proline-alanine-rich protein kinase
5.0
70
62
STK39STK39Q9UEW8Q9UEW8cellularchlorideionhomeostasiscellularhypotonicresponsecellularresponsetochemokinecellularresponsetopotassiumionchemokine(C-X-Cmotif)ligand12signalingpathwayinflammatoryresponseintracellularsignaltransductionmacrophageactivationmaintenanceoflenstransparencynegativeregulationofcreatinetransmembranetransporteractivitynegativeregulationofpancreaticjuicesecretionnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransporteractivitynegativeregulationofsodiumiontransmembranetransporteractivitypeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofiontransmembranetransporteractivitypositiveregulationofp38MAPKcascadepositiveregulationofpotassiumiontransportpositiveregulationofTcellchemotaxisproteinautophosphorylationproteinphosphorylationregulationofbloodpressureregulationofinflammatoryresponseresponsetoaldosteroneresponsetodietaryexcesssignaltransductionsodiumiontransmembranetransport
28S ribosomal protein S12, mitochondrial
5.0
82
56
RT12RT12O15235O15235mitochondrialtranslationtranslation
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
5.0
99
54
I3LK43I3LK43I3LK43I3LK43
Diphosphoinositol polyphosphate phosphohydrolase 1
5.0
101
54
NUDT3NUDT3O95989O95989"adenosine5-(hexahydrogenpentaphosphate)catabolicprocess"cell-cellsignalingdiadenosinehexaphosphatecatabolicprocessdiadenosinepentaphosphatecatabolicprocessdiadenosinepolyphosphatecatabolicprocessdiphosphoinositolpolyphosphatecatabolicprocessdiphosphoinositolpolyphosphatemetabolicprocessRNAdecapping
Mucolipin-3
3.5
49
80
MCLN3MCLN3F6RG56F6RG56cationtransmembranetransportproteinhomotetramerization
Integrator complex subunit 4
5.1
63
62
INT4INT4Q96HW7Q96HW7regulationoftranscriptionelongationbyRNApolymeraseIIsnRNAprocessing
Enhancer of rudimentary homolog
5.1
74
62
ERHERHP84090P84090cellcyclenucleobase-containingcompoundmetabolicprocesspyrimidinenucleosidemetabolicprocess
Peptidyl-prolyl cis-trans isomerase F, mitochondrial
5.1
71
63
PPIFPPIFP30405P30405apoptoticmitochondrialchangescellularresponsetoarsenic-containingsubstancecellularresponsetocalciumioncellularresponsetohydrogenperoxidemitochondrialoutermembranepermeabilizationinvolvedinprogrammedcelldeathnecroptoticprocessnegativeregulationofapoptoticprocessnegativeregulationofATP-dependentactivitynegativeregulationofintrinsicapoptoticsignalingpathwaynegativeregulationofoxidativephosphorylationnegativeregulationofoxidativephosphorylationuncoupleractivitynegativeregulationofreleaseofcytochromecfrommitochondriapositiveregulationofreleaseofcytochromecfrommitochondriaproteinfoldingproteinpeptidyl-prolylisomerizationregulationofmitochondrialmembranepermeabilityregulationofmitochondrialmembranepermeabilityinvolvedinprogrammednecroticcelldeathregulationofnecroticcelldeathregulationofproton-transportingATPaseactivityrotationalmechanismresponsetoischemia
Peptidyl-prolyl cis-trans isomerase E
3.9
nan
78
PPIEPPIEQ9UNP9Q9UNP9mRNAsplicingviaspliceosomepositiveregulationofviralgenomereplicationproteinfoldingproteinpeptidyl-prolylisomerizationregulationofDNA-templatedtranscription
Protein kinase, cAMP dependent regulatory, type II alpha
5.1
69
61
Q8K1M3KAPCAQ8K1M3P05132phosphorylationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetocoldcellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimulusmesodermformationmodulationofchemicalsynaptictransmissionmRNAprocessingnegativeregulationofmeioticcellcyclenegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofinsulinsecretionpositiveregulationofproteinexportfromnucleuspostsynapticmodulationofchemicalsynaptictransmissionproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcellcycleregulationofcellularrespirationregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinprocessingregulationofsynaptictransmissionglutamatergicspermcapacitationspontaneousexocytosisofneurotransmitter
Sister chromatid cohesion protein PDS5 homolog B
3.9
81
74
PDS5BPDS5BQ9NTI5Q9NTI5celldivisioncellpopulationproliferationmitoticsisterchromatidcohesionnegativeregulationofcellpopulationproliferationregulationofcellpopulationproliferation
Pleckstrin homology domain-containing family B member 2
6.0
53
64
PKHB2PKHB2Q96CS7Q96CS7regulationofcelldifferentiation
DNA topoisomerase 3-alpha
5.1
86
52
TOP3ATOP3AQ13472Q13472chromosomeseparationDNAtopologicalchangedouble-strandbreakrepairviahomologousrecombinationmeioticcellcyclemitochondrialDNAmetabolicprocessresolutionofrecombinationintermediates
ATP-dependent DNA/RNA helicase DHX36
5.1
85
55
DHX36DHX36Q05B79Q05B79"3-UTR-mediatedmRNAdestabilization"celldifferentiationcellularresponsetoarseniteioncellularresponsetoheatcellularresponsetoUVdefenseresponsetovirusG-quadruplexDNAunwindinginnateimmuneresponsenegativeregulationoftranslationossificationpositiveregulationofcardioblastdifferentiationpositiveregulationofcytoplasmictranslationpositiveregulationofdendriticspinemorphogenesispositiveregulationofgeneexpressionpositiveregulationofhematopoieticprogenitorcelldifferentiationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofintracellularmRNAlocalization"positiveregulationofmRNA3-endprocessing"positiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationoftelomeremaintenanceviatelomerelengtheningpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationofembryonicdevelopmentregulationofmRNAstabilityregulationoftranscriptionbyRNApolymeraseIIIresponsetoexogenousdsRNARNAsecondarystructureunwindingspermatogenesistelomeraseRNAstabilization
RAC-gamma serine/threonine-protein kinase
5.1
60
64
AKT3AKT3Q9Y243Q9Y243brainmorphogenesishomeostasisofnumberofcellswithinatissueintracellularsignaltransductionmitochondrialgenomemaintenancenegativeregulationofcellularsenescencepeptidyl-serinephosphorylationpositiveregulationofangiogenesispositiveregulationofarterymorphogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcellsizepositiveregulationofendothelialcellproliferationpositiveregulationofTORsignalingpositiveregulationofvascularendothelialcellproliferationproteinphosphorylationsignaltransduction
Guanylate-binding protein 2
5.1
63
66
GBP2GBP2P32456P32456cellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferondefenseresponsetoGram-positivebacteriumdefenseresponsetoprotozoanimmuneresponseproteinlocalizationtonucleus
Metastasis-associated protein MTA1
5.1
57
71
MTA1MTA1Q13330Q13330chromatinremodelingcircadianregulationofgeneexpressiondouble-strandbreakrepairentrainmentofcircadianclockbyphotoperiodepigeneticregulationofgeneexpressionhistonedeacetylationlocomotorrhythmnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinautoubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofcellfatespecificationregulationofstemcelldifferentiationresponsetoionizingradiationsignaltransduction
Interleukin-19
2.0
56
85
IL19IL19Q9UHD0Q9UHD0apoptoticprocessimmuneresponsenegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoflow-densitylipoproteinparticleclearancepositiveregulationofintrinsicapoptoticsignalingpathwayreactiveoxygenspeciesmetabolicprocesssignaltransduction
5'-AMP-activated protein kinase catalytic subunit alpha-2
5.1
42
71
AAPK2AAPK2P54646P54646autophagycellularresponsetocalciumioncellularresponsetoglucosestarvationcellularresponsetoglucosestimuluscellularresponsetonutrientlevelscellularresponsetooxidativestresscellularresponsetoprostaglandinEstimuluscellularresponsetoxenobioticstimuluscholesterolbiosyntheticprocesschromatinorganizationenergyhomeostasisfattyacidbiosyntheticprocessfattyacidhomeostasisglucosehomeostasisintracellularsignaltransductionlipidbiosyntheticprocesslipiddropletdisassemblynegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofTORsignalingnegativeregulationoftubulindeacetylationpositiveregulationofautophagypositiveregulationofglycolyticprocesspositiveregulationofmacroautophagypositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationproteinlocalizationtolipiddropletproteinphosphorylationregulationofcircadianrhythmregulationofmacroautophagyregulationofmicrotubulecytoskeletonorganizationregulationofstressgranuleassemblyresponsetomuscleactivityrhythmicprocesssignaltransductionWntsignalingpathway
NAD(P)H-hydrate epimerase
5.1
94
49
NNRENNREQ8K4Z3Q8K4Z3lipidtransportmembraneraftdistributionnegativeregulationofangiogenesisnicotinamidenucleotidemetabolicprocessregulationofcholesteroleffluxsproutingangiogenesis
Translin-associated protein X
5.1
82
54
✔
TSNAXTSNAXQ99598Q99598celldifferentiationsiRNAprocessingspermatogenesis
F-box/LRR-repeat protein 17
4.3
nan
79
✔
SKP1FXL17P63208Q9UF56chromatinremodelingmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessentrainmentofcircadianclockbyphotoperiodG2/Mtransitionofmitoticcellcyclenervoussystemdevelopmentneuralcrestcelldifferentiationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsregulationofcellcycleregulationofsmoothenedsignalingpathway
Condensin complex subunit 3
5.1
96
50
CND3CND3Q9BPX3Q9BPX3celldivisionmitoticchromosomecondensationpositiveregulationofchromosomecondensationpositiveregulationofchromosomesegregationpositiveregulationofchromosomeseparation
Coronin-6
5.1
90
63
CORO6CORO6Q6QEF8Q6QEF8actinfilamentorganizationcellmigration
Flap endonuclease GEN homolog 1
6.8
48
60
GENGENQ17RS7Q17RS7double-strandbreakrepairviahomologousrecombinationpositiveregulationofmitoticcellcyclespindleassemblycheckpointregulationofcentrosomeduplicationreplicationforkprocessingresolutionofmitoticrecombinationintermediatesresolutionofrecombinationintermediates
Peptidyl-prolyl cis-trans isomerase FKBP5
5.1
66
55
FKBP5FKBP5Q13451Q13451chaperone-mediatedproteinfoldingproteinfoldingproteinpeptidyl-prolylisomerizationresponsetobacterium
Adenosine kinase
5.1
77
59
ADKADKP55263P55263AMPsalvagedAMPsalvagedATPbiosyntheticprocessGMPsalvagephosphorylationpurinenucleobasemetabolicprocesspurineribonucleosidesalvageribonucleosidemonophosphatebiosyntheticprocess
CCR4-NOT transcription complex subunit 6
5.1
96
52
CNOT6CNOT6Q9ULM6Q9ULM6exonucleolyticcatabolismofdeadenylatedmRNAmiRNA-mediatedgenesilencingnuclear-transcribedmRNAcatabolicprocessno-godecaynuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationofcellpopulationproliferationpositiveregulationofcytoplasmicmRNAprocessingbodyassembly
28S ribosomal protein S5, mitochondrial isoform X2
5.1
75
57
F1SU66F1SU66F1SU66F1SU66translation
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma
5.1
65
60
G3V845G3V845G3V845G3V845intracellularsignaltransductionphospholipidcatabolicprocess
Glutamate receptor-interacting protein 1
5.1
45
69
GRIP1GRIP1P97879P97879cellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetophorbol13-acetate12-myristatecerebralcortexdevelopmentdendritearborizationnegativeregulationofAMPAreceptoractivitynervoussystemdevelopmentneurotransmitterreceptortransportendosometopostsynapticmembranepositiveregulationofdendritemorphogenesispositiveregulationofneuronprojectionarborizationpositiveregulationofproteinlocalizationtoplasmamembraneproteinlocalizationproteintransportregulationofkainateselectiveglutamatereceptoractivityregulationofsynapticscalingvesicle-mediatedtransportinsynapse
protein-tyrosine-phosphatase
5.1
63
60
Q62884Q62884Q62884Q62884proteindephosphorylation
Aspartate aminotransferase, mitochondrial
5.1
96
45
AATMAATMP00505P005052-oxoglutaratemetabolicprocess4-hydroxyprolinecatabolicprocessaspartatebiosyntheticprocessaspartatecatabolicprocessaspartatemetabolicprocessfattyacidtransportglutamatecatabolicprocessto2-oxoglutarateglutamatecatabolicprocesstoaspartateglutamatemetabolicprocessoxaloacetatemetabolicprocessresponsetoethanol
Nuclear receptor ROR-beta
5.2
63
61
RORBRORBP45446P45446amacrinecelldifferentiationbraindevelopmentcellularresponsetoretinoicacidcircadianrhythmeyephotoreceptorcelldevelopmentnegativeregulationofDNA-templatedtranscriptionnegativeregulationofosteoblastdifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcircadianrhythmregulationoftranscriptionbyRNApolymeraseIIresponsetohormoneretinadevelopmentincamera-typeeyeretinalconecelldevelopmentretinalrodcelldevelopmentretinalrodcelldifferentiationvisualperception
Barrier-to-autointegration factor
5.2
81
55
✔
BAFBAFO75531O75531chromatinorganizationchromosomecondensationchromosomesegregationDNAintegrationmitoticnuclearmembranereassemblynegativeregulationofinnateimmuneresponsenegativeregulationofproteinADP-ribosylationnegativeregulationoftypeIinterferonproductionnegativeregulationofviralgenomereplicationresponsetooxidativestressresponsetovirus
Protein-arginine deiminase type-2
5.2
70
63
PADI2PADI2Q9Y2J8Q9Y2J8cellularresponsetoleukemiainhibitoryfactorintracellularestrogenreceptorsignalingpathwaynegativeregulationofchemokine-mediatedsignalingpathwaynegativeregulationoflymphocytechemotaxissubstantianigradevelopmenttranscriptioninitiation-coupledchromatinremodeling
Lys-63-specific deubiquitinase BRCC36
5.2
88
52
BRCC3BRCC3P46737P46737celldivisioncellularresponsetoionizingradiationchromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointpositiveregulationofDNArepairpositiveregulationofNLRP3inflammasomecomplexassemblyproteinautoubiquitinationproteindeubiquitinationproteinK63-linkeddeubiquitinationregulationofDNAdamagecheckpointregulationofDNArepairresponsetoionizingradiationresponsetoX-ray
Rho-related GTP-binding protein RhoB
5.2
93
51
RHOBRHOBP62745P62745actinfilamentorganizationangiogenesisapoptoticprocesscelladhesioncelldifferentiationcellmigrationcellularresponsetohydrogenperoxidecellularresponsetoionizingradiationcorticalcytoskeletonorganizationendosometolysosometransportendothelialtubemorphogenesisestablishmentormaintenanceofcellpolarityintracellularproteintransportmitoticcytokinesisnegativeregulationofcellcyclenegativeregulationofcellmigrationpositiveregulationofangiogenesispositiveregulationofapoptoticprocesspositiveregulationofendothelialcellmigrationregulationofactincytoskeletonorganizationregulationofcellmigrationregulationofcellshaperegulationofmodificationofpostsynapticstructureRhoproteinsignaltransduction
Receptor-type tyrosine-protein phosphatase O
5.2
58
61
PTPROPTPROQ16827Q16827axonguidancecellmorphogenesisglomerulusdevelopmentlamellipodiumassemblymonocytechemotaxisnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcell-substrateadhesionnegativeregulationofglomerularfiltrationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofretinalganglioncellaxonguidancepeptidyl-tyrosinedephosphorylationpeptidyl-tyrosinedephosphorylationinvolvedininactivationofproteinkinaseactivitypodocytedifferentiationproteindephosphorylationregulationofglomerularfiltrationregulationofsynapseorganizationslitdiaphragmassembly
cDNA FLJ78721, highly similar to Homo sapiens CHK2 checkpoint homolog (S. pombe) (CHEK2), transcript variant 1, mRNA
5.2
78
54
A8JZZ5A8JZZ5A8JZZ5A8JZZ5proteinphosphorylation
Proteasome assembly chaperone 3
5.2
64
65
PSMG3PSMG3Q9BT73Q9BT73chaperone-mediatedproteincomplexassemblyproteasomeassembly
Isoaspartyl peptidase/L-asparaginase
5.2
110
42
ASGL1ASGL1Q7L266Q7L266asparaginecatabolicprocessviaL-aspartateproteolysis
NADP-dependent malic enzyme, mitochondrial
5.2
85
53
MAONMAONQ16798Q16798aerobicrespirationmalatemetabolicprocessoxygenmetabolicprocesspyruvatemetabolicprocess
Catechol O-methyltransferase
5.2
77
48
✔
COMTCOMTP22734P22734catechol-containingcompoundmetabolicprocesscatecholaminecatabolicprocesscellularresponsetophosphatestarvationdevelopmentalprocessdopaminecatabolicprocessdopaminemetabolicprocessestrogenmetabolicprocessfemalepregnancylearningmethylationmulticellularorganismalreproductiveprocessnegativeregulationofdopaminemetabolicprocessnegativeregulationofrenalsodiumexcretionnegativeregulationofsmoothmusclecellproliferationneurotransmittercatabolicprocesspositiveregulationofhomocysteinemetabolicprocessregulationofsensoryperceptionofpainresponsetoestrogenresponsetolipopolysaccharideresponsetoorganiccycliccompoundresponsetopainresponsetoxenobioticstimulusS-adenosylhomocysteinemetabolicprocessS-adenosylmethioninemetabolicprocessshort-termmemory
Defensin alpha 4
2.0
50
87
DEF4DEF4P12838P12838antibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptideantimicrobialhumoralresponsecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinnateimmuneresponseinmucosakillingofcellsofanotherorganismTcellchemotaxis
Receptor-type tyrosine-protein phosphatase H
5.2
65
61
PTPRHPTPRHQ9HD43Q9HD43apoptoticprocessproteindephosphorylation
Plasma membrane calcium-transporting ATPase 1
4.0
82
73
AT2B1AT2B1P20020P20020agingbraindevelopmentcalciumionexportcalciumionexportacrossplasmamembranecellularcalciumionhomeostasiscellularresponsetocorticosteronestimuluscellularresponsetovitaminDiontransmembranetransportnegativeregulationofcytokineproductionnegativeregulationofcytosoliccalciumionconcentrationneuralretinadevelopmentpositiveregulationofbonemineralizationpositiveregulationofcalciumiontransportregulationofbloodpressureregulationofcardiacconductionregulationofcellularresponsetoinsulinstimulusregulationofcytosoliccalciumionconcentrationregulationofvascularassociatedsmoothmusclecontractionresponsetocold
V-type proton ATPase subunit H
5.2
62
61
VATHVATHF1MZL6F1MZL6pHreductionprotontransmembranetransport
Tonsoku-like protein
5.2
53
68
TONSLTONSLQ96HA7Q96HA7double-strandbreakrepairviahomologousrecombinationreplicationforkprocessing
Protein ILRUN
5.2
67
62
ILRUNILRUNQ9H6K1Q9H6K1innateimmuneresponsemacroautophagynegativeregulationofdefenseresponsetovirusnegativeregulationofDNAbindingnegativeregulationofproteinlocalizationtonucleusnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIinterferonproduction
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
5.2
81
50
✔
NDUV1NDUV2P49821P19404aerobicrespirationmitochondrialATPsynthesiscoupledelectrontransportmitochondrialelectrontransportNADHtoubiquinoneprotonmotiveforce-drivenmitochondrialATPsynthesiscardiacmuscletissuedevelopmentnervoussystemdevelopment
ATP-dependent RNA helicase DDX50
5.2
54
65
✔
DDX50DDX50Q9BQ39Q9BQ39
Mitochondrial import receptor subunit TOM40 homolog
5.2
89
56
✔
TOM40TOM40O96008O96008iontransportproteinimportintomitochondrialmatrixproteininsertionintomitochondrialoutermembraneproteintargetingtomitochondrion
Laforin
5.2
84
61
EPM2AEPM2AO95278O95278autophagosomeassemblycalciumiontransportcarbohydratephosphorylationdephosphorylationglialcellproliferationglycogenbiosyntheticprocessglycogenmetabolicprocesshabituationL-glutamatetransmembranetransportmitochondrionorganizationnegativeregulationofcellcyclenegativeregulationofdephosphorylationnegativeregulationofgeneexpressionnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofphosphataseactivitypeptidyl-tyrosinedephosphorylationphosphorylatedcarbohydratedephosphorylationpositiveregulationofmacroautophagyproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindephosphorylationregulationofcellgrowthregulationofglycogen(starch)synthaseactivityregulationofproteasomalproteincatabolicprocessregulationofproteinimportintonucleusregulationofproteinkinaseactivityregulationofproteinlocalizationtoplasmamembraneregulationofproteinubiquitinationregulationofubiquitinproteinligaseactivityWntsignalingpathway
Ester hydrolase C11orf54
5.2
67
62
CK054CK054Q9H0W9Q9H0W9
Methylmalonyl-CoA mutase, mitochondrial
5.2
77
60
MUTAMUTAP22033P22033homocysteinemetabolicprocesspositiveregulationofGTPaseactivitypost-embryonicdevelopmentpropionatemetabolicprocessmethylmalonylpathwaysuccinyl-CoAbiosyntheticprocess
Rab GTPase-activating protein 1-like
5.2
68
64
RBG1LRBG1LQ5R372Q5R372activationofGTPaseactivityendocytosisproteintransportregulationofproteinlocalization
Peroxisomal biogenesis factor 3
5.2
76
56
PEX3PEX3P56589P56589peroxisomeorganizationproteinimportintoperoxisomemembrane
Cyclic AMP-dependent transcription factor ATF-2
5.2
39
74
ATF2ATF2P15336P15336abducensnucleusdevelopmentadiposetissuedevelopmentamelogenesisapoptoticprocessinvolvedindevelopmentBMPsignalingpathwaybrainstemdevelopmentcellularlipidmetabolicprocesscellularresponsetoanisomycincellularresponsetoDNAdamagestimuluscellularresponsetoleucinestarvationcellularresponsetooxidativestresscellularresponsetovirusdetectionofcelldensityfacialnucleusdevelopmentgrowthplatecartilagechondrocytedifferentiationgrowthplatecartilagechondrocyteproliferationhematopoieticprogenitorcelldifferentiationhepatocyteapoptoticprocesshistoneH2BacetylationhistoneH4acetylationhypoglossalnucleusdevelopmentinuteroembryonicdevelopmentintrinsicapoptoticsignalingpathwayinresponsetohypoxiaJNKcascadeliverdevelopmentmitoticintra-SDNAdamagecheckpointsignalingmotorneuronapoptoticprocessmRNAtranscriptionbyRNApolymeraseIInegativeregulationofangiogenesisnegativeregulationofepithelialcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIneurofilamentcytoskeletonorganizationNKTcelldifferentiationoutflowtractmorphogenesisp38MAPKcascadepeptidyl-threoninephosphorylationpositiveregulationofcardiacmusclemyoblastproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofgeneexpressionpositiveregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspositiveregulationoftransforminggrowthfactorbeta2productionproteinimportintonucleusregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIresponsetoorganiccycliccompoundresponsetoosmoticstressresponsetowaterdeprivationtranscriptioninitiation-coupledchromatinremodelingvacuoleorganizationwhitefatcelldifferentiation
Two pore calcium channel protein 1
3.7
59
76
TPC1TPC1Q9EQJ0Q9EQJ0endocytosisinvolvedinviralentryintohostcellpositiveregulationofautophagyregulationofiontransmembranetransportsodiumiontransmembranetransport
Striated muscle preferentially expressed protein kinase
5.2
74
61
SPEGSPEGQ15772Q15772musclecelldifferentiationmuscleorgandevelopmentnegativeregulationofcellpopulationproliferationproteinphosphorylation
Zinc finger CCHC domain-containing protein 8
3.7
34
91
ZCHC8ZCHC8Q6NZY4Q6NZY4mRNAsplicingviaspliceosomencRNAprocessingsnRNAcatabolicprocess
Rho guanine nucleotide exchange factor 4
5.3
53
62
ARHG4ARHG4Q9NR80Q9NR80filopodiumassemblyintracellularsignaltransductionlamellipodiumassemblyregulationofsmallGTPasemediatedsignaltransduction
Inactive tyrosine-protein kinase PRAG1
5.3
64
63
PRAG1PRAG1Q86YV5Q86YV5cellmigrationnegativeregulationofneuronprojectiondevelopmentpositiveregulationofRhoproteinsignaltransductionproteinphosphorylationregulationofcellmotilityregulationofcellshaperegulationofNotchsignalingpathway
Malate dehydrogenase, cytoplasmic
5.3
101
48
MDHCMDHCP11708P11708malatemetabolicprocessNADHmetabolicprocessoxaloacetatemetabolicprocesstricarboxylicacidcycle
Sentrin-specific protease 1
5.3
89
52
SENP1SENP1Q9P0U3Q9P0U3activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIproteindesumoylationproteinsumoylationproteolysis
Pumilio homolog 3
5.3
60
65
PUM3PUM3Q15397Q15397regulationofproteinADP-ribosylationregulationoftranslation
40S ribosomal protein S14
5.3
72
57
G1U472G1U472G1U472G1U472translation
Stimulator of interferon genes protein
5.3
66
63
A0A2R3XZB7A0A2R3XZB7A0A2R3XZB7A0A2R3XZB7activationofinnateimmuneresponsepositiveregulationoftypeIinterferonproduction
Interleukin-1 receptor-associated kinase 1
5.3
74
57
IRAK1IRAK1P51617P51617activationofNF-kappaB-inducingkinaseactivityagingcellularresponsetoheatcellularresponsetohypoxiacellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwayinnateimmuneresponseinterleukin-1-mediatedsignalingpathwayintracellularsignaltransductionJNKcascadelipopolysaccharide-mediatedsignalingpathwayMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofMAPkinaseactivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofsmoothmusclecellproliferationpositiveregulationoftypeIinterferonproductionproteinautophosphorylationproteinphosphorylationregulationofcytokine-mediatedsignalingpathwayresponsetointerleukin-1responsetolipopolysaccharidetoll-likereceptor2signalingpathwaytoll-likereceptor4signalingpathwaytoll-likereceptor9signalingpathwaytoll-likereceptorsignalingpathwaytypeIinterferon-mediatedsignalingpathway
Tryptophan 5-hydroxylase 1
4.4
nan
75
TPH1TPH1P17752P17752aromaticaminoacidmetabolicprocessboneremodelingcircadianrhythmmammaryglandalveolusdevelopmentnegativeregulationofossificationplateletdegranulationpositiveregulationoffatcelldifferentiationregulationofhemostasisresponsetoimmobilizationstressserotoninbiosyntheticprocess
Integrator complex subunit 9
6.1
53
59
INT9INT9Q9NV88Q9NV88regulationoftranscriptionelongationbyRNApolymeraseII"snRNA3-endprocessing"snRNAprocessing
SWI/SNF complex subunit SMARCC2
5.3
90
51
✔
SMRC2REQUQ8TAQ2Q92785chromatinremodelingnegativeregulationofDNA-templatedtranscriptionnervoussystemdevelopmentnucleosomedisassemblypositiveregulationofcelldifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofTcelldifferentiationregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIIapoptoticprocessapoptoticsignalingpathwaynegativeregulationofmyeloidprogenitorcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseII
Adenylosuccinate synthetase isozyme 1
5.3
97
49
PURA1PURA1P28650P28650"denovoAMPbiosyntheticprocess"AMPbiosyntheticprocessAMPsalvageaspartatemetabolicprocessIMPmetabolicprocesspurinenucleotidemetabolicprocesspurineribonucleosidemonophosphatebiosyntheticprocess
Kinetochore-associated protein DSN1 homolog
5.3
70
59
DSN1NSL1Q9H410Q96IY1celldivisionmitoticsisterchromatidsegregation
Guanine nucleotide exchange factor for Rab-3A
5.3
51
70
R3GEFR3GEFQ8TBN0Q8TBN0exocytosisproteintransport
BRO1 domain-containing protein BROX
5.3
72
64
BROXBROXQ5VW32Q5VW32
Protein arginine N-methyltransferase 1
5.3
58
64
ANM1ANM1Q63009Q63009cardiacmuscletissuedevelopmenthistoneH4-R3methylationhistonemethylationhistonemodificationinuteroembryonicdevelopmentliverregenerationnegativeregulationofJNKcascadenegativeregulationofmegakaryocytedifferentiationneuronprojectiondevelopmentpeptidyl-argininemethylationpeptidyl-argininemethylationtoasymmetrical-dimethylargininepeptidyl-arginineomega-N-methylationpositiveregulationofcellpopulationproliferationpositiveregulationoferythrocytedifferentiationpositiveregulationofhemoglobinbiosyntheticprocesspositiveregulationofp38MAPKcascadeproteinhomooligomerizationproteinmethylationregulationofmegakaryocytedifferentiationRNAsplicing
Tyrosine-protein kinase
5.3
49
69
Q506Q0Q506Q0Q506Q0Q506Q0adaptiveimmuneresponsechromatinorganizationcytokine-mediatedsignalingpathwayintracellularsignaltransductionpositiveregulationofcellpopulationproliferationregulationofcelladhesionregulationofmulticellularorganismalprocess
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
5.3
72
59
SGTASGTAO43765O43765negativeregulationofER-associatedubiquitin-dependentproteincatabolicprocessnegativeregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofER-associatedubiquitin-dependentproteincatabolicprocesspost-translationalproteintargetingtoendoplasmicreticulummembranetail-anchoredmembraneproteininsertionintoERmembraneubiquitin-dependentERADpathway
Exportin-1
5.3
67
59
XPO1SPN1Q6P5F9O95149mRNAtransportnegativeregulationoftranscriptionbyRNApolymeraseIInucleocytoplasmictransportproteinexportfromnucleusproteinlocalizationtonucleusregulationofcentrosomeduplicationregulationofproteasomalubiquitin-dependentproteincatabolicprocessregulationofproteincatabolicprocessregulationofproteinexportfromnucleusribosomallargesubunitexportfromnucleusribosomalsmallsubunitexportfromnucleusribosomalsubunitexportfromnucleusribosomebiogenesisproteinimportintonucleusRNAimportintonucleussnRNAimportintonucleus
S-adenosylhomocysteine hydrolase-like protein 1
5.7
65
55
SAHH2SAHH2O43865O43865angiotensin-activatedsignalingpathwayapoptoticprocessepithelialfluidtransportmitochondrion-endoplasmicreticulummembranetetheringmRNApolyadenylationone-carbonmetabolicprocesspositiveregulationofsodiumiontransportproteinexportfromnucleusregulationofaniontransportregulationofiontransmembranetransporteractivity"regulationofmRNA3-endprocessing"responsetocalciumionS-adenosylmethioninecycle
DNA polymerase epsilon subunit 2
5.3
54
63
DPOE2DPOE2P56282P56282DNArepairDNAreplicationDNA-templatedDNAreplicationerror-pronetranslesionsynthesis
Skeletal muscle myosin heavy chain MyHC-EO/IIL
5.3
68
60
Q9GJP9Q9GJP9Q9GJP9Q9GJP9cellularresponsetostarvation
Leucyl-cystinyl aminopeptidase
5.3
64
64
LCAPLCAPQ9UIQ6Q9UIQ6antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassITAP-independentcell-cellsignalingfemalepregnancynegativeregulationofcold-inducedthermogenesispeptidecatabolicprocessproteincatabolicprocessproteinpolyubiquitinationproteolysisregulationofbloodpressuresignaltransductionSMADproteinsignaltransduction
COP9 signalosome complex subunit 3
5.3
84
51
CSN3CSN3Q9UNS2Q9UNS2inuteroembryonicdevelopmentproteindeneddylationproteinneddylationregulationofDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorregulationofproteinneddylationresponsetolightstimulussignaltransductionubiquitin-dependentproteincatabolicprocess
Tensin-2
5.3
52
68
TENS2TENS2Q63HR2Q63HR2cellularhomeostasiscollagenmetabolicprocesskidneydevelopmentmulticellularorganismgrowthmulticellularorganismalhomeostasisnegativeregulationofcellpopulationproliferationnegativeregulationofinsulinreceptorsignalingpathwaypeptidyl-tyrosinedephosphorylationresponsetomuscleactivity
SH2 domain-containing protein 1A
5.3
85
58
SH21ASH21AO60880O60880adaptiveimmuneresponsecell-cellsignalingcellulardefenseresponsehumoralimmuneresponsenaturalkillercellmediatedcytotoxicitynegativeregulationofTcellreceptorsignalingpathwaypositiveregulationofnaturalkillercellmediatedcytotoxicityregulationofimmuneresponseregulationofsignaltransduction
Translation initiation factor eIF-2B subunit alpha
5.3
83
51
✔
EI2BAEI2BAQ14232Q14232oligodendrocytedevelopmentresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiation
Phosphoinositide kinase, FYVE-type zinc finger containing
5.3
68
60
E9PDH4E9PDH4E9PDH4E9PDH4intracellularsignaltransductionphosphorylation
Integrator complex subunit 6
5.3
52
66
INT6INT6Q9UL03Q9UL03regulationoftranscriptionelongationbyRNApolymeraseII"snRNA3-endprocessing"snRNAprocessing
28S ribosomal protein S5, mitochondrial
5.3
80
53
RT05RT05P82675P82675mitochondrialtranslationtranslation
Bardet-Biedl syndrome 5 protein homolog
5.3
60
62
A6QLF9A6QLF9A6QLF9A6QLF9ciliumassemblyintracellulartransportproteintransport
Cleavage and polyadenylation specificity factor subunit 2
5.8
66
62
CPSF2CPSF2Q9P2I0Q9P2I0"mRNA3-endprocessingbystem-loopbindingandcleavage"mRNApolyadenylationpre-mRNAcleavagerequiredforpolyadenylation
Interferon regulatory factor 5
5.3
65
60
IRF5IRF5Q13568Q13568cytokine-mediatedsignalingpathwaydefenseresponsetovirusimmunesystemprocessinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticprocesspositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-12productionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIinterferonproductionregulationoftranscriptionbyRNApolymeraseIIresponsetomuramyldipeptideresponsetopeptidoglycan
Protein zwilch homolog
5.4
83
56
ZWILCZWILCQ9H900Q9H900celldivisionmitoticspindleassemblycheckpointsignalingproteinlocalizationtokinetochore
V-type proton ATPase subunit
5.4
70
59
Q5M7T6Q5M7T6Q5M7T6Q5M7T6braindevelopmentcellularironionhomeostasiscellularresponsetoincreasedoxygenlevelssynapticvesiclelumenacidificationvacuolaracidificationvacuolartransport
Transcription factor SPT20 homolog
5.4
41
71
SP20HSP20HQ8NEM7Q8NEM7autophagygastrulationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseII
Telomerase Cajal body protein 1
5.4
83
51
TCAB1TCAB1Q9BUR4Q9BUR4CajalbodyorganizationDNArepairpositiveregulationofDNArepairpositiveregulationofdouble-strandbreakrepairpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationoftelomeraseactivityproteinlocalizationtoCajalbodyRNAfoldingscaRNAlocalizationtoCajalbodytelomeraseRNAlocalizationtoCajalbodytelomereformationviatelomerasetelomeremaintenanceviatelomerase
Sodium/hydrogen exchanger 3
5.4
93
55
SL9A3SL9A3P48764P48764iontransportpotassiumiontransmembranetransportregulationofintracellularpHsodiumionimportacrossplasmamembrane
Excitatory amino acid transporter 2
5.4
67
60
EAA2EAA2P43004P43004adultbehaviorcellularresponsetococainecellularresponsetoextracellularstimuluschemicalsynaptictransmissionD-aspartateimportacrossplasmamembraneglutathionebiosyntheticprocessiontransportL-aspartateimportacrossplasmamembraneL-aspartatetransmembranetransportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportmulticellularorganismagingmulticellularorganismgrowthneurotransmitterreuptakeneurotransmittertransportpositiveregulationofglucoseimportproteinhomotrimerizationresponsetoaminoacidresponsetowoundingresponsetoxenobioticstimulustelencephalondevelopmenttransepithelialtransporttransportacrossblood-brainbarriervisualbehavior
TBC1 domain family member 15
8.7
45
55
F1SH24F1SH24F1SH24F1SH24
Peptidyl-prolyl cis-trans isomerase D
5.4
73
58
PPIDPPIDP26882P26882apoptoticprocesscellularresponsetoUV-Achaperone-mediatedproteinfoldinglipiddropletorganizationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofapoptoticprocesspositiveregulationofproteinsecretionpositiveregulationofviralgenomereplicationproteinfoldingproteinpeptidyl-prolylisomerizationproteintransportprotein-containingcomplexassembly
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
5.4
92
55
F1RVN1F1RVN1F1RVN1F1RVN1mitochondrialelectrontransportNADHtoubiquinone
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
5.4
80
53
B7Z5J6B7Z5J6B7Z5J6B7Z5J6smallGTPasemediatedsignaltransduction
Telomerase-binding protein EST1A
5.4
63
62
EST1AEST1AQ86US8Q86US8mRNAexportfromnucleusnegativeregulationoftelomerecappingnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecayregulationofdephosphorylationregulationoftelomeraseactivityregulationoftelomeremaintenanceregulationoftelomeremaintenanceviatelomerase
Glutathione S-transferase P
5.4
45
58
GSTP1GSTP1P09211P09211cellularresponsetolipopolysaccharidecentralnervoussystemdevelopmentcommonmyeloidprogenitorcellproliferationglutathionederivativebiosyntheticprocessglutathionemetabolicprocesshepoxilinbiosyntheticprocesslinoleicacidmetabolicprocessnegativeregulationofacuteinflammatoryresponsenegativeregulationofapoptoticprocessnegativeregulationofbiosyntheticprocessnegativeregulationofERK1andERK2cascadenegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoffibroblastproliferationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinterleukin-1betaproductionnegativeregulationofJUNkinaseactivitynegativeregulationofleukocyteproliferationnegativeregulationofMAPkinaseactivitynegativeregulationofMAPKcascadenegativeregulationofmonocytechemotacticprotein-1productionnegativeregulationofnitric-oxidesynthasebiosyntheticprocessnegativeregulationofproteinkinaseactivitynegativeregulationofstress-activatedMAPKcascadenegativeregulationoftumornecrosisfactorproductionnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynitricoxidestoragepositiveregulationofsuperoxideaniongenerationprostaglandinmetabolicprocessregulationofERK1andERK2cascaderegulationofstress-activatedMAPKcascaderesponsetoreactiveoxygenspeciesxenobioticmetabolicprocess
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
5.4
91
58
W5PUX0W5NRY1W5PUX0W5NRY1
S-phase kinase-associated protein 2
5.4
64
58
✔
SKP2SKP1Q13309P63208defenseresponsetovirusG1/StransitionofmitoticcellcycleG2/Mtransitionofmitoticcellcycleinnateimmuneresponsepositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofproteinpolyubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationregulationofapoptoticprocessregulationofcellcycleSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocesschromatinremodelingmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitination
Dihydropyrimidinase-related protein 3
5.4
104
47
DPYL3DPYL3Q14195Q14195actincrosslinkformationactinfilamentbundleassemblycellularresponsetocytokinestimulusnegativeregulationofcellmigrationnegativeregulationofneuronprojectiondevelopmentneurondevelopmentpositiveregulationoffilopodiumassemblypositiveregulationofneuronprojectiondevelopmentresponsetoaxoninjury
11-beta-hydroxysteroid dehydrogenase 1
5.4
68
58
DHI1DHI1P28845P28845lungdevelopmentsteroidcatabolicprocess
39S ribosomal protein L38, mitochondrial
5.4
54
68
F1RW03F1RW03F1RW03F1RW03
Carbonyl reductase [NADPH] 3
5.4
74
55
CBR3CBR3O75828O75828cognitionxenobioticmetabolicprocess
Fibroblast growth factor receptor substrate 3
5.5
53
72
FRS3FRS3O43559O43559fibroblastgrowthfactorreceptorsignalingpathwaysignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Dihydropyrimidinase-like 3
5.5
106
46
Q8IXW6Q8IXW6Q8IXW6Q8IXW6
Ribosome maturation protein SBDS
5.5
80
56
SBDSSBDSQ9Y3A5Q9Y3A5bonemarrowdevelopmentbonemineralizationcytosolicribosomeassemblyhematopoieticprogenitorcelldifferentiationinnercellmasscellproliferationleukocytechemotaxismitoticspindleorganizationrRNAprocessing
Probable tRNA(His) guanylyltransferase
5.5
71
56
THG1THG1Q9NWX6Q9NWX6mitochondrialfusionproteinhomotetramerizationresponsetooxidativestressstress-inducedmitochondrialfusiontRNAmodificationtRNAprocessing
DNA-directed RNA polymerases I and III subunit RPAC1
5.5
71
54
RPAC1RPAC2O15160P0DPB6transcriptionbyRNApolymeraseIDNA-templatedtranscription
TBC1 domain family member 23
5.5
66
56
TBC23TBC23Q9NUY8Q9NUY8braindevelopmentembryonicbraindevelopmentneuronprojectiondevelopmentretrogradetransportendosometoGolgivesicletetheringtoGolgivesicle-mediatedtransport
CCR4-NOT transcription complex subunit 10
5.0
62
69
CNO10CNO11Q9H9A5Q9UKZ1mRNAcatabolicprocessnegativeregulationoftranslationnuclear-transcribedmRNApoly(A)tailshorteningRNA-mediatedgenesilencing
Glutathione peroxidase 2
5.5
73
53
GPX2GPX2P18283P18283responsetooxidativestress
Protein CIP2A
5.5
54
64
CIP2ACIP2AQ8TCG1Q8TCG1
Prolactin regulatory element-binding protein
5.5
66
66
PREBPREBQ9HCU5Q9HCU5COPIIvesiclecoatingendoplasmicreticulumtoGolgivesicle-mediatedtransportproteinexitfromendoplasmicreticulumproteinsecretionregulationofCOPIIvesiclecoating
Armadillo repeat-containing protein 8
5.5
83
52
ARMC8ARMC8Q8IUR7Q8IUR7proteasome-mediatedubiquitin-dependentproteincatabolicprocess
Tubulin beta-3 chain
5.5
53
62
✔
TBB3TBB3Q13509Q13509axonguidancedorsalrootgangliondevelopmentmicrotubulecytoskeletonorganizationmitoticcellcycle
Bestrophin-2
5.5
92
52
BEST2BEST2Q8NFU1Q8NFU1membranedepolarizationsensoryperceptionofsmell
Pre-mRNA-splicing regulator WTAP
5.5
59
62
FL2DFL2DQ15007Q15007cellcyclemRNAmethylationmRNAprocessingregulationofalternativemRNAsplicingviaspliceosomeRNAsplicing
Proline-serine-threonine phosphatase-interacting protein 1
5.5
64
50
PPIP1PPIP1O43586O43586actinfilamentpolymerizationcelladhesionendocytosisinflammatoryresponseinnateimmuneresponsesignaltransduction
IQ motif and SEC7 domain-containing protein 2
5.6
64
60
IQEC2IQEC2Q5JU85Q5JU85actincytoskeletonorganizationmodulationofchemicalsynaptictransmissionregulationofARFproteinsignaltransductionregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembrane
Exosome complex component RRP46
5.6
87
49
EXOS5EXOS5Q9NQT4Q9NQT4defenseresponsetovirusDNAdeaminationexonucleolyticcatabolismofdeadenylatedmRNAnuclearmRNAsurveillance"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5""polyadenylation-dependentsnoRNA3-endprocessing"RNAcatabolicprocessRNAprocessingrRNAcatabolicprocessrRNAprocessing"U4snRNA3-endprocessing"
(E3-independent) E2 ubiquitin-conjugating enzyme
6.6
73
51
UBE2OUBE2OQ9C0C9Q9C0C9negativeregulationofapoptoticprocesspositiveregulationofBMPsignalingpathwayproteinK63-linkedubiquitinationproteinmonoubiquitinationretrogradetransportendosometoGolgi
Caveolin-1
5.6
47
66
CAV1CAV1Q03135Q03135angiogenesisangiotensin-activatedsignalingpathwayinvolvedinheartprocessapoptoticsignalingpathwaybasementmembraneorganizationcalciumionhomeostasiscalciumiontransportcaveolaassemblycaveolin-mediatedendocytosiscelldifferentiationcellularcalciumionhomeostasiscellularnitricoxidehomeostasiscellularresponsetoexogenousdsRNAcellularresponsetohyperoxiacellularresponsetopeptidehormonestimuluscellularresponsetostarvationcellularresponsetotransforminggrowthfactorbetastimuluscholesterolhomeostasischolesteroltransportcytokine-mediatedsignalingpathwayendothelialcellproliferationestablishmentoflocalizationincellfibroblastproliferationglandularepithelialcelldifferentiationinsulinreceptorinternalizationlactationlipidstoragemaintenanceofproteinlocationincellmammaryglanddevelopmentmammaryglandinvolutionMAPKcascademembranedepolarizationmusclecellcellularhomeostasisnegativeregulationofanoikisnegativeregulationofBMPsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofendothelialcellproliferationnegativeregulationofepithelialcelldifferentiationnegativeregulationoffibroblastproliferationnegativeregulationofinwardrectifierpotassiumchannelactivitynegativeregulationofMAPkinaseactivitynegativeregulationofMAPKcascadenegativeregulationofnecroptoticprocessnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofnitric-oxidesynthaseactivitynegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofpeptidyl-tyrosineautophosphorylationnegativeregulationofpinocytosisnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofproteinbindingnegativeregulationofproteintyrosinekinaseactivitynegativeregulationofproteinubiquitinationnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynegativeregulationoftyrosinephosphorylationofSTATproteinnitricoxidebiosyntheticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcatalyticactivitypositiveregulationofcelladhesionmoleculeproductionpositiveregulationofcellmigrationpositiveregulationofcholesteroleffluxpositiveregulationofcold-inducedthermogenesispositiveregulationofER-associatedubiquitin-dependentproteincatabolicprocesspositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofgapjunctionassemblypositiveregulationofgeneexpressionpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinubiquitinationpositiveregulationoftoll-likereceptor3signalingpathwaypositiveregulationofvasoconstrictionpost-transcriptionalregulationofgeneexpressionproteinlocalizationproteinlocalizationtobasolateralplasmamembraneproteinlocalizationtoplasmamembraneraftproteintransportreceptorinternalizationreceptorinternalizationinvolvedincanonicalWntsignalingpathwayreceptor-mediatedendocytosisofvirusbyhostcellregulationofbloodcoagulationregulationofcardiacmusclecellactionpotentialinvolvedinregulationofcontractionregulationofcellcommunicationbyelectricalcouplinginvolvedincardiacconductionregulationofcytosoliccalciumionconcentrationregulationofentryofbacteriumintohostcellregulationoffattyacidmetabolicprocessregulationofheartratebycardiacconductionregulationofmembranerepolarizationduringactionpotentialregulationofpeptidaseactivityregulationofruffleassemblyregulationofsmoothmusclecontractionregulationoftheforceofheartcontractionbychemicalsignalregulationofventricularcardiacmusclecellactionpotentialresponsetobacteriumresponsetocalciumionresponsetoestrogenresponsetohypoxiaresponsetoischemiaresponsetoprogesteroneskeletalmuscletissuedevelopmentTcellcostimulationtriglyceridemetabolicprocesstyrosinephosphorylationofSTATproteinvasculogenesisvasoconstrictionvesicleorganization
Tubulin beta chain
5.6
77
57
E1BJB1E1BJB1E1BJB1E1BJB1cerebralcortexdevelopmentmicrotubule-basedprocess
Bile salt export pump
5.6
55
63
ABCBBABCBBO95342O95342bileacidandbilesalttransportbileacidbiosyntheticprocessbileacidmetabolicprocessbileacidsignalingpathwaycanalicularbileacidtransportcholesterolhomeostasisfattyacidmetabolicprocesslipidhomeostasisphospholipidhomeostasispositiveregulationofbileacidsecretionproteinubiquitinationregulationofbileacidmetabolicprocessregulationoffattyacidbeta-oxidationregulationofgeneexpressionresponseto17alpha-ethynylestradiolresponsetoestrogenresponsetoethanolresponsetooxidativestresstransmembranetransportxenobioticexportfromcellxenobioticmetabolicprocessxenobiotictransmembranetransport
SKI3 subunit of superkiller complex protein
5.8
53
65
SKI3SKI3Q6PGP7Q6PGP7"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5"
Protein ENL
5.6
66
54
ENLENLQ03111Q03111chromatinremodelinghistoneacetylationnegativeregulationofproteinkinaseactivityregulationoftranscriptionbyRNApolymeraseII
FYN-binding protein 1
5.6
47
63
FYB1FYB1O15117O15117immuneresponseintegrin-mediatedsignalingpathwayproteinlocalizationtoplasmamembraneTcellreceptorsignalingpathway
DNA-directed RNA polymerase III subunit RPC5
5.6
75
54
RPC5RPC5Q9NVU0Q9NVU0defenseresponsetovirusDNA-templatedtranscriptioninnateimmuneresponse
Single-stranded DNA-binding protein 2
5.6
54
66
SSBP2SSBP2P81877P81877positiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscription
Glutathione S-transferase omega-2
5.6
67
60
GSTO2GSTO2Q9H4Y5Q9H4Y5cellularresponsetoarsenic-containingsubstanceglutathionemetabolicprocessL-ascorbicacidmetabolicprocessxenobioticmetabolicprocess
Guanine nucleotide exchange factor C9orf72
5.4
nan
68
CI072CI072Q96LT7Q96LT7autophagyaxonextensionendocytosislateendosometolysosometransportnegativeregulationofexocytosisnegativeregulationofGTPbindingnegativeregulationofimmuneresponsenegativeregulationofproteinphosphorylationpositiveregulationofGTPaseactivitypositiveregulationofmacroautophagyregulationofactinfilamentorganizationregulationofautophagosomeassemblyregulationofautophagyregulationofproteinlocalizationregulationofTORC1signalingstressgranuleassembly
Cytoplasmic dynein 1 light intermediate chain 2
5.6
78
50
DC1L2DC1L2O43237O43237cellularresponsetonervegrowthfactorstimuluscentrosomelocalizationmicrotubulecytoskeletonorganizationmicrotubule-basedmovement
Myocyte-specific enhancer factor 2C
5.7
54
67
MEF2CMEF2CQ8CFN5Q8CFN5apoptoticprocessBcellhomeostasisBcellproliferationBcellreceptorsignalingpathwaybloodvesseldevelopmentbloodvesselremodelingcardiacmusclecelldifferentiationcardiacmusclehypertrophyinresponsetostresscardiacventricleformationcartilagemorphogenesiscelldifferentiationcellfatecommitmentcellmorphogenesisinvolvedinneurondifferentiationcellproliferationinbonemarrowcellularresponsetocalciumioncellularresponsetofluidshearstresscellularresponsetogrowthfactorstimuluscellularresponsetolipopolysaccharidecellularresponsetoparathyroidhormonestimuluscellularresponsetoretinoicacidcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotrichostatinAcellularresponsetoxenobioticstimuluschondrocytedifferentiationembryonichearttubedevelopmentembryonicskeletalsystemmorphogenesisembryonicviscerocraniummorphogenesisendochondralossificationepithelialcellproliferationinvolvedinrenaltubulemorphogenesisexcitatorypostsynapticpotentialgeneexpressiongerminalcenterformationglomerulusmorphogenesisheartdevelopmentheartloopinghumoralimmuneresponselearningormemoryMAPKcascademelanocytedifferentiationmonocytedifferentiationmusclecellfatedeterminationnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofepithelialcellproliferationnegativeregulationofgeneexpressionnegativeregulationofneuronapoptoticprocessnegativeregulationofossificationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationnegativeregulationofvascularendothelialcellproliferationnephrontubuleepithelialcelldifferentiationneuralcrestcelldifferentiationneurondevelopmentneurondifferentiationneuronmigrationosteoblastdifferentiationoutflowtractmorphogenesisplateletformationpositiveregulationofalkalinephosphataseactivitypositiveregulationofBcellproliferationpositiveregulationofbehavioralfearresponsepositiveregulationofbonemineralizationpositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcellproliferationinbonemarrowpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofmacrophageapoptoticprocesspositiveregulationofMAPkinaseactivitypositiveregulationofmyoblastdifferentiationpositiveregulationofneurondifferentiationpositiveregulationofosteoblastdifferentiationpositiveregulationofskeletalmusclecelldifferentiationpositiveregulationofskeletalmuscletissuedevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIprimaryheartfieldspecificationregulationofAMPAreceptoractivityregulationofdendriticspinedevelopmentregulationofDNA-templatedtranscriptionregulationofgerminalcenterformationregulationofmegakaryocytedifferentiationregulationofneuronapoptoticprocessregulationofneurotransmittersecretionregulationofNMDAreceptoractivityregulationofsarcomereorganizationregulationofsynapseassemblyregulationofsynapticactivityregulationofsynapticplasticityregulationofsynaptictransmissionglutamatergicregulationoftranscriptionbyRNApolymeraseIIrenaltubulemorphogenesisresponsetoischemiaroofofmouthdevelopmentsecondaryheartfieldspecificationsemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesinoatrialvalvemorphogenesisskeletalmusclecelldifferentiationskeletalmuscletissuedevelopmentsmoothmusclecelldifferentiationsympatheticneuronaxonguidancetransdifferentiationventricularcardiacmusclecelldifferentiation
Rho guanine nucleotide exchange factor 1
5.7
79
53
ARHG1ARHG1Q92888Q92888Gprotein-coupledreceptorsignalingpathwayregulationofsmallGTPasemediatedsignaltransductionRhoproteinsignaltransduction
Catechol O-methyltransferase domain-containing protein 1
5.7
66
60
CMTD1CMTD1Q86VU5Q86VU5methylation
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
5.7
81
49
STT3BSTT3BQ8TCJ2Q8TCJ2co-translationalproteinmodificationglycoproteincatabolicprocesspost-translationalproteinmodificationproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineresponsetounfoldedproteinubiquitin-dependentERADpathway
V-type proton ATPase subunit d 1
5.7
69
59
VA0D1VA0D1P61420P61420cellularironionhomeostasiscellularresponsetoincreasedoxygenlevelsciliumassemblypHreductionprotontransmembranetransportvacuolaracidificationvacuolartransport
DNA nucleotidylexotransferase
5.7
63
57
Q3UZ80Q3UZ80Q3UZ80Q3UZ80DNAmodificationDNArepair
Origin recognition complex subunit 3
6.9
59
57
ORC3ORC3Q9UBD5Q9UBD5DNAreplicationDNAreplicationinitiationglialcellproliferationneuralprecursorcellproliferationregulationofDNAreplication
XK-related protein
5.7
64
56
Q5GH54Q5GH54Q5GH54Q5GH54apoptoticprocessinvolvedindevelopmentengulfmentofapoptoticcellphosphatidylserineexposureonapoptoticcellsurface
Low molecular weight phosphotyrosine protein phosphatase
5.7
85
50
✔
PPACPPACP24666P24666proteindephosphorylation
DCC-interacting protein 13-alpha
5.7
61
65
DP13ADP13AQ9UKG1Q9UKG1adiponectin-activatedsignalingpathwaycellcyclecellularresponsetohepatocytegrowthfactorstimulusinsulinreceptorsignalingpathwaymaintenanceofsynapsestructurenegativeregulationofFc-gammareceptorsignalingpathwayinvolvedinphagocytosispositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofglucoseimportpositiveregulationofmacropinocytosispositiveregulationofmelaninbiosyntheticprocessproteinimportintonucleusregulationoffibroblastmigrationregulationofG1/Stransitionofmitoticcellcycleregulationofglucoseimportregulationofinnateimmuneresponseregulationofproteinlocalizationtoplasmamembraneregulationoftoll-likereceptor4signalingpathwaysignaltransductionsignalingtransforminggrowthfactorbetareceptorsignalingpathway
Uncharacterized protein
5.7
77
53
A0A4X1UMF3A0A4X1UMF3A0A4X1UMF3A0A4X1UMF3
Serine/threonine-protein kinase PLK1
5.7
59
62
✔
PLK1PLK1Q07832Q07832centrosomecycleestablishmentofmitoticspindleorientationestablishmentofproteinlocalizationfemalemeiosischromosomesegregationG2/MtransitionofmitoticcellcyclehomologouschromosomesegregationmicrotubulebundleformationmitoticcellcyclemitoticcytokinesismitoticG2DNAdamagecheckpointsignalingmitoticsisterchromatidsegregationmitoticspindleassemblycheckpointsignalingnegativeregulationofapoptoticprocessnegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInuclearmembranedisassemblypeptidyl-serinephosphorylationpolarbodyextrusionaftermeioticdivisionspositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteolysispositiveregulationofubiquitinproteinligaseactivitypositiveregulationofubiquitin-proteintransferaseactivityproteindestabilizationproteinlocalizationtochromatinproteinlocalizationtonuclearenvelopeproteinlocalizationtoorganelleproteinphosphorylationproteinubiquitinationregulationofcytokinesisregulationofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofmitoticspindleassemblyregulationofproteinbindingregulationofproteinlocalizationtocellcortexsynaptonemalcomplexdisassembly
Serine/threonine-protein kinase TAO3
5.7
93
49
TAOK3TAOK3Q9H2K8Q9H2K8cellularresponsetoDNAdamagestimulusDNArepairintracellularsignaltransductionMAPKcascademitoticG2DNAdamagecheckpointsignalingnegativeregulationofJNKcascadeneuronprojectionmorphogenesispositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofstress-activatedMAPKcascadeproteinautophosphorylationproteinphosphorylationregulationofMAPKcascade
Talin rod domain-containing protein 1
5.7
87
53
TLRN1TLRN1Q9H1K6Q9H1K6
Septin-2
6.0
58
60
✔
SEPT2SEPT2P42208P42208ciliumassemblycytoskeleton-dependentcytokinesisneuronprojectiondevelopmentproteinpolymerizationregulationofexocytosisregulationofL-glutamateimportacrossplasmamembraneregulationofproteinlocalizationsmoothenedsignalingpathwayspermatogenesis
Solute carrier family 2, facilitated glucose transporter member 3
5.7
108
41
GTR3GTR3P11169P11169carbohydratemetabolicprocessdehydroascorbicacidtransportgalactosetransmembranetransportglucoseimportglucoseimportacrossplasmamembraneglucosetransmembranetransportL-ascorbicacidmetabolicprocessmonosaccharidetransmembranetransporttransportacrossblood-brainbarrier
Glutathione S-transferase Mu 1
5.7
75
51
GSTM1GSTM1P09488P09488cellulardetoxificationofnitrogencompoundglutathionederivativebiosyntheticprocessglutathionemetabolicprocesshepoxilinbiosyntheticprocessnitrobenzenemetabolicprocessprostaglandinmetabolicprocessxenobioticcatabolicprocess
Serine/threonine-protein kinase TAO2
5.7
92
49
TAOK2TAOK2Q9JLS3Q9JLS3actincytoskeletonorganizationaxonogenesisbasaldendritearborizationbasaldendritemorphogenesiscellularresponsetoDNAdamagestimulusfocaladhesionassemblyintracellularsignaltransductionMAPKcascademitoticG2DNAdamagecheckpointsignalingneuronprojectionmorphogenesispositiveregulationofJNKcascadepositiveregulationofMAPKcascadepositiveregulationofstress-activatedMAPKcascadeproteinphosphorylationregulationofactincytoskeletonorganizationregulationofcellshaperegulationofMAPKcascaderegulationofpostsynapseorganizationregulationofsynapticmembraneadhesionstress-activatedMAPKcascade
Interleukin enhancer-binding factor 3
5.7
89
48
ILF3ILF3Q9Z1X4Q9Z1X4defenseresponsetovirusnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranslationnegativeregulationofviralgenomereplicationpositiveregulationofDNA-templatedtranscriptionproteinmethylationproteinphosphorylation
Glucokinase regulatory protein
5.7
78
49
GCKRGCKRQ14397Q14397carbohydratederivativemetabolicprocesscarbohydratemetabolicprocessglucosehomeostasisnegativeregulationofglucokinaseactivityproteinimportintonucleusresponsetofructosetriglyceridehomeostasisuratemetabolicprocess
Cystathionine gamma-lyase
5.7
79
56
CGLCGLP32929P32929cellularresponsetoleukemiainhibitoryfactorcysteinebiosyntheticprocesscysteinebiosyntheticprocessviacystathioninecysteinemetabolicprocessendoplasmicreticulumunfoldedproteinresponsehydrogensulfidebiosyntheticprocesslipidmetabolicprocessnegativeregulationofapoptoticsignalingpathwaypositiveregulationofaorticsmoothmusclecelldifferentiationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinhomotetramerizationproteinsulfhydrationprotein-pyridoxal-5-phosphatelinkageviapeptidyl-N6-pyridoxalphosphate-L-lysinetranssulfuration
RNA helicase
5.7
85
53
B2RQS6B2RQS6B2RQS6B2RQS6
Bromodomain-containing protein 4
5.7
67
56
BRD4BRD4Q9ESU6Q9ESU6cellularresponsetoDNAdamagestimuluschromatinremodelingchromosomesegregationhistoneH3-K14acetylationhistoneH4-K12acetylationinnercellmasscellproliferationnegativeregulationbyhostofviraltranscriptionnegativeregulationofDNAdamagecheckpointpositiveregulationofDNAbindingpositiveregulationofDNA-templatedtranscriptionpositiveregulationofG2/MtransitionofmitoticcellcyclepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinautophosphorylationproteinphosphorylationregulationofDNA-templatedtranscriptionregulationofinflammatoryresponseregulationoftranscriptioninvolvedinG1/Stransitionofmitoticcellcycle
Diacylglycerol O-acyltransferase 1
3.9
64
73
DGAT1DGAT1O75907O75907diacylglycerolmetabolicprocessfattyacidhomeostasislipidstoragelong-chainfatty-acyl-CoAmetabolicprocessmonoacylglycerolbiosyntheticprocesstriglyceridebiosyntheticprocesstriglyceridemetabolicprocessvery-low-densitylipoproteinparticleassembly
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
5.7
87
51
SMCA5SMCA5O60264O60264cellularresponsetoleukemiainhibitoryfactorchromatinremodelingDNArepairDNA-templatedtranscriptioninitiationheterochromatinformationnegativeregulationofmitoticchromosomecondensationnegativeregulationoftranscriptionbyRNApolymeraseInucleosomeassemblypositiveregulationofDNAreplicationpositiveregulationofhistoneacetylationpositiveregulationofhistonedeacetylationpositiveregulationofhistonemethylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIrDNAheterochromatinformationregulationofDNAmethylationregulationofDNAreplicationregulationofDNA-templatedtranscriptionregulationofresponsetoDNAdamagestimulusregulationoftranscriptionbyRNApolymeraseII
Dual specificity mitogen-activated protein kinase kinase 4
5.7
50
61
MP2K4MP2K4P45985P45985apoptoticprocesscellgrowthinvolvedincardiacmusclecelldevelopmentcellularresponsetomechanicalstimuluscellularresponsetosorbitolcellularsenescenceFc-epsilonreceptorsignalingpathwayJNKcascadeMAPKcascadenegativeregulationofmotorneuronapoptoticprocesspositiveregulationofDNAreplicationpositiveregulationofJNKcascadepositiveregulationofneuronapoptoticprocesspositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellapoptoticprocessresponsetowoundingsignaltransduction
Actin, cytoplasmic 2
5.7
77
54
ACTGACTGP63261P63261angiogenesiscellularresponsetotypeIIinterferonmaintenanceofblood-brainbarriermorphogenesisofapolarizedepitheliumplateletaggregationpositiveregulationofcellmigrationpositiveregulationofgeneexpressionpositiveregulationofwoundhealingproteinlocalizationtobicellulartightjunctionregulationoffocaladhesionassemblyregulationofstressfiberassemblyregulationofsynapticvesicleendocytosisregulationoftransepithelialtransportresponsetocalciumionresponsetomechanicalstimulusretinahomeostasissarcomereorganizationtightjunctionassembly
Mediator of RNA polymerase II transcription subunit 10
5.7
69
60
MED10MED14Q9BTT4O60244positiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblypositiveregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIsomaticstemcellpopulationmaintenance
Myocyte-specific enhancer factor 2B
5.7
71
54
MEF2BMEF2BQ02080Q02080celldifferentiationmuscleorgandevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Cyclin-dependent kinase 13
5.7
61
60
✔
CDK13CDK13Q14004Q14004alternativemRNAsplicingviaspliceosomehemopoiesisnegativeregulationofstemcelldifferentiationphosphorylationofRNApolymeraseIIC-terminaldomainpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinphosphorylationregulationofsignaltransductiontranscriptionelongationbyRNApolymeraseIIpromoter
E3 ubiquitin-protein ligase MYLIP
4.3
79
72
MYLIPMYLIPQ8WY64Q8WY64cholesterolhomeostasisnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationofneuronprojectiondevelopmentnervoussystemdevelopmentpositiveregulationofproteincatabolicprocessproteindestabilizationproteinubiquitinationregulationoflow-densitylipoproteinparticlereceptorcatabolicprocessubiquitin-dependentproteincatabolicprocess
DCC-interacting protein 13-beta
5.7
66
61
DP13BDP13BQ8NEU8Q8NEU8adiponectin-activatedsignalingpathwaycellcyclecellularresponsetohepatocytegrowthfactorstimuluscoldacclimationdietinducedthermogenesisglucosehomeostasisnegativeregulationofcellularresponsetoinsulinstimulusnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffattyacidoxidationnegativeregulationofglucoseimportnegativeregulationofneuralprecursorcellproliferationnegativeregulationofneurogenesispositiveregulationofcold-inducedthermogenesispositiveregulationofFc-gammareceptorsignalingpathwayinvolvedinphagocytosispositiveregulationofmacropinocytosispositiveregulationofphagocytosisengulfmentproteinhomotetramerizationproteinimportintonucleusregulationoffibroblastmigrationregulationofG1/Stransitionofmitoticcellcycleregulationofinnateimmuneresponseregulationoftoll-likereceptor4signalingpathwaysignaltransductionsignalingtransforminggrowthfactorbetareceptorsignalingpathway
Tubulin beta chain
5.7
71
56
A0A2K5HGL3A0A2K5HGL3A0A2K5HGL3A0A2K5HGL3microtubule-basedprocess
Dual specificity protein phosphatase 10
5.7
81
48
DUS10DUS10Q9Y6W6Q9Y6W6dephosphorylationnegativeregulationofcellmigrationnegativeregulationofepithelialcellmigrationnegativeregulationofepithelialcellproliferationnegativeregulationofepitheliumregenerationnegativeregulationofERK1andERK2cascadenegativeregulationofJNKcascadenegativeregulationofJUNkinaseactivitynegativeregulationofMAPKcascadenegativeregulationofoligodendrocytedifferentiationnegativeregulationofp38MAPKcascadenegativeregulationofproteinkinaseactivitybyregulationofproteinphosphorylationnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseoligodendrocytedifferentiationpeptidyl-threoninedephosphorylationpeptidyl-tyrosinedephosphorylationinvolvedininactivationofproteinkinaseactivitypositiveregulationofregulatoryTcelldifferentiationregulationofadaptiveimmuneresponseregulationofbrownfatcelldifferentiationresponsetolipopolysaccharidestress-activatedMAPKcascade
Trifunctional enzyme subunit beta, mitochondrial
5.7
98
45
ECHBECHBP55084P55084cellularresponsetolipopolysaccharidefattyacidbeta-oxidationgeneexpression
Nucleic acid dioxygenase ALKBH1
5.7
73
56
ALKB1ALKB1Q13686Q13686developmentalgrowthDNAdealkylationinvolvedinDNArepairDNAdemethylationDNArepairinuteroembryonicdevelopmentnegativeregulationofneuronapoptoticprocessneuronmigrationneuronprojectiondevelopmentoxidativedemethylationoxidativeRNAdemethylationoxidativesingle-strandedDNAdemethylationplacentadevelopmentregulationofmitochondrialtranslationregulationoftranslationalelongationregulationoftranslationalinitiationRNArepairtRNAdemethylationtRNAwobblecytosinemodification
Tyrosine-protein phosphatase non-receptor type 23
5.7
84
50
PTN23PTN23Q9H3S7Q9H3S7ciliumassemblyearlyendosometolateendosometransportendocyticrecyclingnegativeregulationofepithelialcellmigrationpositiveregulationofadherensjunctionorganizationpositiveregulationofearlyendosometolateendosometransportpositiveregulationofhomophiliccelladhesionpositiveregulationofWntproteinsecretionproteindephosphorylationproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
glycerol kinase
5.7
60
65
A0A287BD08A0A287BD08A0A287BD08A0A287BD08glycerolcatabolicprocessglycerolmetabolicprocessglycerol-3-phosphatebiosyntheticprocessphosphorylationtriglyceridemetabolicprocess
Neurolysin, mitochondrial
5.8
67
61
NEULNEULQ9BYT8Q9BYT8Gprotein-coupledreceptorsignalingpathwaypeptidemetabolicprocessproteolysisregulationofgluconeogenesisregulationofskeletalmusclefiberdifferentiation
Mixed lineage kinase domain-like protein
5.8
72
58
MLKLMLKLQ8NB16Q8NB16cellsurfacereceptorsignalingpathwaydefenseresponsetovirusexecutionphaseofnecroptosisnecroptoticprocessnecroptoticsignalingpathwayproteinhomotrimerizationproteinphosphorylation
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
5.8
84
52
A0A287BDC0A0A287BDC0A0A287BDC0A0A287BDC0
Ubiquitin-associated and SH3 domain-containing protein B
5.8
72
53
UBS3BUBS3BQ8TF42Q8TF42collagen-activatedtyrosinekinasereceptorsignalingpathwaynegativeregulationofboneresorptionnegativeregulationofosteoclastdifferentiationnegativeregulationofplateletaggregationnegativeregulationofproteinkinaseactivitynegativeregulationofsignaltransductionpeptidyl-tyrosinedephosphorylationplateletaggregationregulationofosteoclastdifferentiationregulationofproteinbindingregulationofreleaseofsequesteredcalciumionintocytosol
Cytokine-like nuclear factor N-PAC
5.8
86
51
GLYR1GLYR1Q6P1Q2Q6P1Q2positiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseII
RISC-loading complex subunit TARBP2
5.8
56
66
✔
TRBP2TRBP2Q15633Q15633globalgenesilencingbymRNAcleavagemiRNAprocessingmulticellularorganismgrowthnegativeregulationofdefenseresponsetovirusbyhostnegativeregulationofproteinkinaseactivityneuralprecursorcellproliferationpositiveregulationofmusclecelldifferentiationpositiveregulationoftranslationpositiveregulationofviralgenomereplicationpre-miRNAprocessingregulationofmiRNAmaturationregulationofproductionofsmallRNAinvolvedingenesilencingbyRNAregulationofsiRNAproductionregulationofviraltranscriptionRISCcomplexassemblysinglefertilizationsiRNAprocessingskeletalmuscletissueregenerationspermatiddevelopment
Solute carrier family 26 member 9
5.8
58
58
S26A9S26A9Q7LBE3Q7LBE3aniontransportchloridetransmembranetransportchloridetransportiontransportpositiveregulationofgeneexpression
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
5.8
59
59
NAPEPNAPEPQ6IQ20Q6IQ20host-mediatedregulationofintestinalmicrobiotacompositionN-acylethanolaminemetabolicprocessN-acylphosphatidylethanolaminemetabolicprocessphospholipidcatabolicprocesspositiveregulationofbrownfatcelldifferentiationpositiveregulationofinflammatoryresponseretinoidmetabolicprocesstemperaturehomeostasis
Choline transporter-like protein 1
5.8
42
64
CTL1CTL1Q8WWI5Q8WWI5cholinecatabolicprocesscholinetransportphosphatidylcholinebiosyntheticprocesstransmembranetransporttransportacrossblood-brainbarrier
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
6.6
78
51
✔
NDUS8NDUS8Q8K3J1Q8K3J1aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetooxidativestress
Histone H3.1
5.8
86
47
H31H31P68431P68431epigeneticregulationofgeneexpressionnucleosomeassemblytelomereorganization
Transcription factor Dp-1
5.8
64
64
TFDP1TFDP1Q14186Q14186anoikisepidermisdevelopmentnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationoffatcellproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNAbiosyntheticprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcycletranscriptionbyRNApolymeraseII
3-ketoacyl-CoA thiolase, peroxisomal
5.8
103
47
✔
THIKTHIKP09110P09110alpha-linolenicacidmetabolicprocessbileacidmetabolicprocessfattyacidbeta-oxidationfattyacidbeta-oxidationusingacyl-CoAoxidasephenylacetatecatabolicprocessverylong-chainfattyacidmetabolicprocess
Synaptic vesicle membrane protein VAT-1 homolog
5.8
109
45
VAT1VAT1Q99536Q99536negativeregulationofmitochondrialfusion
Pre-mRNA-splicing factor 38A
5.8
76
55
PR38APR38AQ8NAV1Q8NAV1mRNAsplicingviaspliceosome
Signal recognition particle receptor subunit beta
5.8
82
52
G1STG2G1STG2G1STG2G1STG2
Mothers against decapentaplegic homolog 2
5.4
64
62
SMAD2SMAD2Q15796Q15796activinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesisanterior/posteriorpatternspecificationaorticvalvemorphogenesiscelldifferentiationcellfatecommitmentcommon-partnerSMADproteinphosphorylationDNA-templatedtranscriptionembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisendocardialcushionmorphogenesisendodermformationgastrulationinuteroembryonicdevelopmentinsulinsecretionintracellularsignaltransductionlungdevelopmentmesodermformationnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnodalsignalingpathwayorgangrowthpancreasdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgeneexpressionpositiveregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetrypositiveregulationoftranscriptionbyRNApolymeraseIIpost-embryonicdevelopmentprimarymiRNAprocessingpulmonaryvalvemorphogenesisregulationofbindingregulationoftransforminggrowthfactorbetareceptorsignalingpathwayresponsetocholesterolresponsetoglucosesecondarypalatedevelopmentsignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingzygoticspecificationofdorsal/ventralaxis
Aldo-keto reductase family 1 member C2
5.8
74
50
AK1C2AK1C2P52895P52895cellularresponsetojasmonicacidstimuluscellularresponsetoprostaglandinDstimulusdaunorubicinmetabolicprocessdigestiondoxorubicinmetabolicprocessepithelialcelldifferentiationGprotein-coupledreceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofproteinkinaseBsignalingprogesteronemetabolicprocessprostaglandinmetabolicprocesssteroidmetabolicprocess
Centromere protein O
5.8
59
67
CENPOCENPOQ9BU64Q9BU64centromerecomplexassembly
Cytosolic non-specific dipeptidase
5.8
87
46
CNDP2CNDP2Q96KP4Q96KP4proteolysis
Peptidyl-prolyl cis-trans isomerase G
4.1
78
69
PPIGPPIGQ13427Q13427proteinfoldingproteinpeptidyl-prolylisomerizationRNAsplicing
Amphiphysin
5.8
59
61
AMPHAMPHP49418P49418chemicalsynaptictransmissionendocytosissynapticvesicleendocytosis
Armadillo repeat-containing protein 7
5.8
92
47
ARMC7ARMC7Q9H6L4Q9H6L4
Vesicle-associated membrane protein 7
5.8
65
56
VAMP7VAMP7P70280P70280calcium-ionregulatedexocytosisendoplasmicreticulumtoGolgivesicle-mediatedtransportendosometolysosometransporteosinophildegranulationexocytosisGolgitoplasmamembraneproteintransportnaturalkillercelldegranulationneutrophildegranulationphagocytosisengulfmentpositiveregulationofdendritemorphogenesispositiveregulationofhistaminesecretionbymastcellregulationofproteintargetingtovacuolarmembraneSNAREcomplexassemblytriglyceridetransportvesiclefusionvesiclefusionwithGolgiapparatusvesicletransportalongmicrotubulevesicle-mediatedtransport
COP9 signalosome complex subunit 7a
5.9
67
55
CSN7ACSN7AQ9UBW8Q9UBW8COP9signalosomeassemblyproteindeneddylationproteinneddylationregulationofproteinneddylation
M-phase inducer phosphatase 1
7.3
58
55
MPIP1MPIP1P30304P30304celldivisioncellpopulationproliferationcellularresponsetoUVG1/StransitionofmitoticcellcycleG2/MtransitionofmitoticcellcyclepositiveregulationofG2/MtransitionofmitoticcellcyclepositiveregulationofG2/MItransitionofmeioticcellcycleproteindephosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityresponsetoradiation
Serine/threonine-protein kinase haspin
5.9
74
56
HASPHASPQ8TF76Q8TF76chromatinorganizationintracellularsignaltransductionmitoticcellcyclemitoticsisterchromatidcohesionmitoticspindleassemblycheckpointsignalingproteinlocalizationtochromosomecentromericregionproteinphosphorylation
AP2-associated protein kinase 1
8.2
65
48
AAK1AAK1Q2M2I8Q2M2I8membraneorganizationpositiveregulationofNotchsignalingpathwaypresynapticendocytosisproteinautophosphorylationproteinphosphorylationproteinstabilizationregulationofclathrin-dependentendocytosisregulationofproteinlocalization
Signal peptidase complex subunit 2
5.9
58
64
SPCS2SPCS2Q15005Q15005proteintargetingtoERsignalpeptideprocessing
E3 ubiquitin-protein ligase RFWD3
2.1
63
82
RFWD3RFWD3Q6PCD5Q6PCD5cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairviahomologousrecombinationinterstrandcross-linkrepairmitoticG1DNAdamagecheckpointsignalingproteinubiquitinationregulationofDNAdamagecheckpointreplicationforkprocessingresponsetoionizingradiation
SKI2 subunit of superkiller complex protein
5.9
66
62
SKI2SKI2Q15477Q15477"nuclear-transcribedmRNAcatabolicprocess3-5exonucleolyticnonsense-mediateddecay"RNAcatabolicprocess
Eukaryotic translation initiation factor 2 subunit 3
5.9
81
53
IF2GIF2GP41091P41091formationoftranslationpreinitiationcomplextranslationalinitiation
Synaptotagmin-13
5.9
55
64
SYT13SYT13Q7L8C5Q7L8C5calcium-ionregulatedexocytosiscellularresponsetocalciumionregulationofcalciumion-dependentexocytosisregulationofdopaminesecretionvesiclefusionvesicle-mediatedtransport
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
5.9
85
51
A0A4X1SVK9A0A4X1SVK9A0A4X1SVK9A0A4X1SVK9mitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyresponsetooxidativestress
Polypyrimidine tract-binding protein 1
5.9
42
67
PTBP1PTBP1P26599P26599IRES-dependentviraltranslationalinitiationmRNAprocessingnegativeregulationofmRNAsplicingviaspliceosomenegativeregulationofmusclecelldifferentiationnegativeregulationofRNAsplicingpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofproteindephosphorylationregulationofalternativemRNAsplicingviaspliceosomeregulationofcelldifferentiationregulationofRNAsplicingRNAsplicing
Heterogeneous nuclear ribonucleoprotein D0
5.9
58
59
✔
HNRPDHNRPDQ14103Q14103"3-UTR-mediatedmRNAdestabilization"cellularresponsetoaminoacidstimuluscellularresponsetoestradiolstimuluscellularresponsetonitricoxidecellularresponsetoputrescinecerebellumdevelopmentcircadianregulationoftranslationCRD-mediatedmRNAstabilizationhepatocytededifferentiationliverdevelopmentmRNAtranscriptionbyRNApolymeraseIInegativeregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofcytoplasmictranslationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftelomeraseRNAreversetranscriptaseactivitypositiveregulationoftelomerecappingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationregulationofcircadianrhythmregulationofDNA-templatedtranscriptionregulationofgeneexpressionregulationoftelomeremaintenanceresponsetocalciumionresponsetoelectricalstimulusresponsetorapamycinresponsetosodiumphosphateRNAcatabolicprocessRNAprocessing
Methyltransferase-like protein 17, mitochondrial
5.9
73
55
MET17MET17Q9H7H0Q9H7H0methylationribosomalsmallsubunitbiogenesistranslation
WD repeat domain phosphoinositide-interacting protein 3
4.3
nan
79
WIPI3WIPI3Q5MNZ6Q5MNZ6autophagosomeassemblyautophagyofmitochondrionautophagyofnucleuscellularresponsetostarvationproteinlipidationproteinlocalizationtophagophoreassemblysite
Transformation/transcription domain-associated protein
5.9
80
50
F2Z2U4F2Z2U4F2Z2U4F2Z2U4peptidyl-aminoacidmodificationpositiveregulationofresponsetostimulusregulationofcellularresponsetostressregulationofnucleobase-containingcompoundmetabolicprocess
Twinkle mtDNA helicase
5.9
81
53
PEO1PEO1Q96RR1Q96RR1cellularresponsetoglucosestimulusDNAunwindinginvolvedinDNAreplicationmitochondrialDNAreplicationmitochondrialtranscriptionproteinhexamerization
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
5.9
90
47
PDE3APDE3AQ14432Q14432apoptoticsignalingpathwaycAMP-mediatedsignalingcellularresponsetocGMPcellularresponsetotransforminggrowthfactorbetastimuluscGMP-mediatedsignalingGprotein-coupledreceptorsignalingpathwaylipidmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofcAMP-mediatedsignalingnegativeregulationofvascularpermeabilityoocytematurationpositiveregulationofoocytedevelopmentpositiveregulationofvascularpermeabilityregulationofmeioticnucleardivisionregulationofribonucleaseactivityresponsetoxenobioticstimulussignaltransduction
Receptor-type tyrosine-protein phosphatase N2
5.9
62
58
PTPR2PTPR2Q92932Q92932insulinsecretioninvolvedincellularresponsetoglucosestimuluslipidmetabolicprocessneurotransmittersecretionproteindephosphorylationregulationofsecretion
E3 ubiquitin-protein ligase TRIM9
6.0
36
67
✔
TRIM9TRIM9Q9C026Q9C026proteasome-mediatedubiquitin-dependentproteincatabolicprocess
Geranylgeranyl transferase type-2 subunit beta
3.6
nan
72
PGTB2YKT6P53611O15498proteingeranylgeranylationproteinmodificationprocessproteinprenylationvisualperceptionendoplasmicreticulumtoGolgivesicle-mediatedtransportproteintransportretrogradetransportendosometoGolgivesicledockinginvolvedinexocytosisvesicletargeting
Low molecular weight phosphotyrosine protein phosphatase
6.0
83
47
Q561M1Q561M1Q561M1Q561M1proteindephosphorylation
ATP-dependent 6-phosphofructokinase, muscle type
6.0
79
54
PFKAMPFKAMP08237P08237canonicalglycolysisfructose16-bisphosphatemetabolicprocessfructose6-phosphatemetabolicprocessglucosehomeostasisglycogencatabolicprocessglycolysisfromstoragepolysaccharidethroughglucose-1-phosphateglycolyticprocessglycolyticprocessthroughfructose-6-phosphatemusclecellcellularhomeostasispositiveregulationofinsulinsecretionpositiveregulationoftranscriptionbyRNApolymeraseII
DNA-directed RNA polymerase, mitochondrial
6.0
73
49
RPOMRPOMO00411O00411mitochondrialtranscriptiontranscriptioninitiationatmitochondrialpromoter
Mitochondrial dynamics protein MID51
6.0
75
52
MID51MID51Q8BGV8Q8BGV8cellularresponsetohypoxiamitochondrialfissionpositiveregulationofmitochondrialfissionpositiveregulationofmitochondrialtranslationpositiveregulationofproteintargetingtomembrane
HMG box-containing protein 1
4.9
27
80
HBP1HBP1O60381O60381regulationofcellcycleregulationoftranscriptionbyRNApolymeraseIIWntsignalingpathway
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
6.0
77
57
PTENPTENP60484P60484apoptoticprocessbrainmorphogenesiscanonicalWntsignalingpathwaycellmigrationcellmotilitycellularresponsetoelectricalstimuluscentralnervoussystemdevelopmentcentralnervoussystemmyelinmaintenancecentralnervoussystemneuronaxonogenesisdendriticspinemorphogenesisdentategyrusdevelopmentdephosphorylationforebrainmorphogenesisheartdevelopmentinositolphosphatedephosphorylationlearningormemorylocalizationlocomotorrhythmlocomotorybehaviormulticellularorganismalresponsetostressnegativeregulationofaxonogenesisnegativeregulationofcellcycleG1/Sphasetransitionnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofcellsizenegativeregulationofcellularsenescencenegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofdendriticspinemorphogenesisnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofERK1andERK2cascadenegativeregulationofexcitatorypostsynapticpotentialnegativeregulationoffocaladhesionassemblynegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofkeratinocytemigrationnegativeregulationofneuronprojectiondevelopmentnegativeregulationoforgangrowthnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofphosphatidylinositol3-kinasesignalingnegativeregulationofproteinkinaseBsignalingnegativeregulationofproteinphosphorylationnegativeregulationofsynapticvesicleclusteringnegativeregulationofvascularassociatedsmoothmusclecellproliferationnegativeregulationofwoundhealingspreadingofepidermalcellsneuron-neuronsynaptictransmissionphosphatidylinositol3-kinasesignalingphosphatidylinositolbiosyntheticprocessphosphatidylinositoldephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofTRAIL-activatedapoptoticsignalingpathwaypositiveregulationofubiquitinproteinligaseactivitypositiveregulationofubiquitin-dependentproteincatabolicprocesspostsynapticdensityassemblyprepulseinhibitionpresynapticmembraneassemblyproteindephosphorylationproteinkinaseBsignalingproteinstabilizationregulationofcellularcomponentsizeregulationofneuronprojectiondevelopmentregulationofproteinkinaseBsignalingregulationofproteinstabilityrhythmicsynaptictransmissionsocialbehaviorsynapseassemblysynapsematuration
Protein inscuteable homolog
6.0
65
58
INSCINSCQ1MX18Q1MX18apicalproteinlocalizationasymmetriccelldivisioncelldifferentiationestablishmentofmitoticspindleorientationnervoussystemdevelopmentregulationofasymmetriccelldivisionregulationofproteinstability
Cyclin-K
6.0
98
41
CCNKCCNKO75909O75909cellcyclecelldivisioncellularresponsetoDNAdamagestimulusnegativeregulationbyhostofviralgenomereplicationphosphorylationofRNApolymeraseIIC-terminaldomainpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationofphosphorylationofRNApolymeraseIIC-terminaldomainserine2residuespositiveregulationoftranscriptionelongationbyRNApolymeraseIIregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofsignaltransductionregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
NK-tumor recognition protein
4.3
74
77
NKTRNKTRP30414P30414proteinfoldingproteinpeptidyl-prolylisomerization
Testis-specific chromodomain protein Y 2
6.0
80
51
CDY2CDY2Q9Y6F7Q9Y6F7spermatogenesis
Structural maintenance of chromosomes protein 4
6.0
78
55
SMC4SMC4Q9NTJ3Q9NTJ3celldivisionkinetochoreorganizationmeioticchromosomecondensationmeioticchromosomesegregationmitoticchromosomecondensationmitoticsisterchromatidsegregationpositiveregulationofchromosomecondensationpositiveregulationofchromosomesegregationpositiveregulationofchromosomeseparation
Guanine nucleotide exchange factor DBS
3.2
63
76
MCF2LMCF2LQ63406Q63406positiveregulationofRhoproteinsignaltransductionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcatalyticactivityRhoproteinsignaltransduction
Plexin-D1
2.0
38
88
PLXD1PLXD1Q3UH93Q3UH93angiogenesisaortadevelopmentbranchinginvolvedinbloodvesselmorphogenesiscardiacseptumdevelopmentcoronaryvasculaturedevelopmentdichotomoussubdivisionofterminalunitsinvolvedinsalivaryglandbranchingendothelialcellmigrationkidneydevelopmentnegativeregulationofcelladhesionnegativeregulationofneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofaxonogenesispositiveregulationofproteinbindingregulationofangiogenesisregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivitysemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancesynapseassemblysynaptictargetrecognition
Grancalcin
6.0
81
46
GRANGRANP28676P28676membranefusion
Protein 4.1
4.6
56
69
EPB41EPB41P11171P11171actincytoskeletonorganizationactomyosinstructureorganizationcellcyclecelldivisioncorticalactincytoskeletonorganizationpositiveregulationofproteinbindingpositiveregulationofproteinlocalizationtocellcortexregulationofcalciumiontransportregulationofcellshaperegulationofintestinalabsorption
Isobutyryl-CoA dehydrogenase, mitochondrial
6.0
90
53
ACAD8ACAD8Q9UKU7Q9UKU7lipidmetabolicprocessvalinecatabolicprocess
Sialidase-2
6.0
97
47
NEUR2NEUR2Q9Y3R4Q9Y3R4cellularoligosaccharidecatabolicprocessgangliosidecatabolicprocessglycoproteincatabolicprocessglycosphingolipidmetabolicprocessoligosaccharidecatabolicprocess
Kelch repeat and BTB domain-containing protein 4
6.0
65
59
KBTB4KBTB4Q9NVX7Q9NVX7
DNA topoisomerase 3-beta-1
6.0
70
56
TOP3BTOP3BO95985O95985chromosomesegregationDNAtopologicalchange
Acetyl-coenzyme A thioesterase
7.0
75
49
ACO12ACO12Q8WYK0Q8WYK0acetyl-CoAmetabolicprocessacyl-CoAmetabolicprocessfattyacidmetabolicprocess
Serine/threonine-protein phosphatase 2A activator
6.0
65
54
PTPAPTPAQ15257Q15257mitoticspindleorganizationnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationofproteindephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofproteindephosphorylationregulationofphosphoproteinphosphataseactivity
Integrator complex subunit 8
6.0
76
48
INT8INT8Q75QN2Q75QN2regulationoftranscriptionelongationbyRNApolymeraseII"snRNA3-endprocessing"snRNAprocessing
SH3 and cysteine-rich domain-containing protein 2
6.0
50
63
STAC2STAC2Q6ZMT1Q6ZMT1positiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofvoltage-gatedcalciumchannelactivityskeletalmusclecontraction
Serine/threonine-protein kinase/endoribonuclease IRE1
6.0
78
44
ERN1ERN1O75460O75460cellularresponsetoglucosestimuluscellularresponsetohydrogenperoxidecellularresponsetounfoldedproteincellularresponsetovascularendothelialgrowthfactorstimulusendothelialcellproliferationinsulinmetabolicprocessintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressIRE1-mediatedunfoldedproteinresponsemRNAcatabolicprocessmRNAcleavagemRNAcleavageinvolvedinmRNAprocessingmRNAsplicingviaendonucleolyticcleavageandligationpeptidyl-serineautophosphorylationpeptidyl-serinetrans-autophosphorylationpositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationofJUNkinaseactivitypositiveregulationofRNAsplicingpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinautophosphorylationproteinphosphorylationregulationofmacroautophagyresponsetoendoplasmicreticulumstress
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
6.0
87
48
DDAH1DDAH1O94760O94760argininecatabolicprocessargininemetabolicprocesscitrullinemetabolicprocessnegativeregulationofcellpopulationproliferationnegativeregulationofcellularresponsetohypoxianegativeregulationofvascularpermeabilitynitricoxidemediatedsignaltransductionpositiveregulationofangiogenesispositiveregulationofnitricoxidebiosyntheticprocessregulationofnitric-oxidesynthaseactivityregulationofsystemicarterialbloodpressure
E3 ubiquitin-protein ligase COP1
6.0
93
45
COP1COP1Q8NHY2Q8NHY2positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessresponsetoionizingradiation
Deoxynucleotidyltransferase terminal-interacting protein 1
6.0
81
48
TDIF1TDIF1Q9H147Q9H147
Protein arginine N-methyltransferase 6
2.1
nan
87
ANM6ANM6Q6NZB1Q6NZB1cellularsenescencechromatinorganizationDNArepairhistonemethylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofhistonedeacetylaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-argininemethylationtoasymmetrical-dimethylargininepeptidyl-arginineN-methylationproteinmodificationprocessregulationofmitochondrionorganizationregulationofsignaltransductionbyp53classmediator
Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein
6.0
71
51
Q5IRN4Q5IRN4Q5IRN4Q5IRN4animalorgandevelopmentnervoussystemdevelopmentpositiveregulationoftranscriptionbyRNApolymeraseII
Glutathione peroxidase 1
6.0
75
49
GPX1GPX1P07203P07203agingangiogenesisinvolvedinwoundhealingarachidonicacidmetabolicprocessbiologicalprocessinvolvedininteractionwithsymbiontbloodvesselendothelialcellmigrationcellredoxhomeostasiscellularresponsetoglucosestimuluscellularresponsetooxidativestressendothelialcelldevelopmentepigeneticregulationofgeneexpressionfatcelldifferentiationfibroblastproliferationglutathionemetabolicprocessheartcontractionhydrogenperoxidecatabolicprocessintrinsicapoptoticsignalingpathwayinresponsetooxidativestresslipoxygenasepathwaymyoblastdifferentiationmyoblastproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofinflammatoryresponsetoantigenicstimulusnegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofreleaseofcytochromecfrommitochondrianeuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationofsupramolecularfiberorganizationproteinoxidationregulationofmammaryglandepithelialcellproliferationregulationofproteasomalproteincatabolicprocessresponsetoestradiolresponsetofolicacidresponsetogammaradiationresponsetohormoneresponsetohydrogenperoxideresponsetohydroperoxideresponsetonicotineresponsetoseleniumionresponsetosymbioticbacteriumresponsetovitaminEresponsetoxenobioticstimulussensoryperceptionofsoundskeletalmusclefiberdevelopmentskeletalmuscletissueregenerationtemperaturehomeostasistriglyceridemetabolicprocessUVprotectionvasodilation
LLGL scribble cell polarity complex component 2
6.0
76
52
L2GL2L2GL2Q6P1M3Q6P1M3celldivisioncorticalactincytoskeletonorganizationestablishmentofspindleorientationestablishmentormaintenanceofepithelialcellapical/basalpolarityexocytosisleucinetransportregulationofestablishmentormaintenanceofcellpolarityregulationofNotchsignalingpathwayregulationofproteinsecretion
Lysine--tRNA ligase
6.0
53
67
✔
SYKSYKQ15046Q15046basophilactivationinvolvedinimmuneresponsediadenosinetetraphosphatebiosyntheticprocessERK1andERK2cascadelysyl-tRNAaminoacylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofinflammatoryresponsetoantigenicstimuluspositiveregulationofmacrophageactivationresponsetoX-raytRNAprocessing
Antigen peptide transporter 2
6.0
71
52
TAP2TAP2Q03519Q03519antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-dependentantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbviaERpathwayTAP-dependentantigenprocessingandpresentationofexogenousproteinantigenviaMHCclassIbTAP-dependentcytosoltoendoplasmicreticulumtransportpeptideantigentransportpeptidetransportpositiveregulationofTcellmediatedcytotoxicityproteintransportresponsetomoleculeofbacterialoriginTcellmediatedcytotoxicitytransmembranetransport
BMP-2-inducible protein kinase
6.0
84
48
✔
BMP2KBMP2KQ9NSY1Q9NSY1positiveregulationofNotchsignalingpathwayproteinphosphorylationregulationofbonemineralizationregulationofclathrin-dependentendocytosis
Signal recognition particle subunit SRP72
6.0
72
53
SRP72SRP72O76094O76094SRP-dependentcotranslationalproteintargetingtomembrane
Small nuclear ribonucleoprotein Sm D3
6.0
88
49
✔
SMD3SMD3P62318P623187-methylguanosinecaphypermethylationmRNAsplicingviaspliceosomeproteinmethylationRNAsplicingspliceosomalsnRNPassemblyU2-typeprespliceosomeassembly
Fatty-acid amide hydrolase 1
6.0
94
45
FAAH1FAAH1P97612P97612fattyacidcatabolicprocessfattyacidmetabolicprocessmonoacylglycerolcatabolicprocesspositiveregulationofvasoconstriction
40S ribosomal protein S11
6.0
75
55
G1TRM4G1TRM4G1TRM4G1TRM4translation
Serine/threonine-protein kinase TBK1
6.0
75
54
✔
TBK1TBK1Q9UHD2Q9UHD2activationofinnateimmuneresponsedefenseresponsetoGram-positivebacteriumdefenseresponsetovirusdendriticcellproliferationI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponsenegativeregulationofgeneexpressionpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofmacroautophagypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwaypositiveregulationofxenophagyproteinphosphorylationregulationofneurondeathregulationoftypeIinterferonproductionresponsetovirustypeIinterferon-mediatedsignalingpathway
N-acetyl-D-glucosamine kinase
6.0
88
47
NAGKNAGKQ9UJ70Q9UJ70N-acetylglucosaminemetabolicprocessN-acetylmannosaminemetabolicprocessN-acetylneuraminatecatabolicprocess
Probable ATP-dependent RNA helicase DDX6
6.0
59
63
DDX6DDX6P26196P26196miRNA-mediatedgenesilencingbyinhibitionoftranslationnegativeregulationofneurondifferentiationnegativeregulationoftranslationneurondifferentiationP-bodyassemblystemcellpopulationmaintenancestressgranuleassemblyviralRNAgenomepackaging
Probable G-protein coupled receptor 88
6.0
79
50
GPR88GPR88Q9GZN0Q9GZN0cellularresponsetolightstimulusGprotein-coupledreceptorsignalingpathwaylocomotorybehaviormotorlearningneuromuscularprocesscontrollingbalanceneuronalactionpotentialphototransduction
Unconventional myosin-VIIb
6.8
71
51
MYO7BMYO7BQ99MZ6Q99MZ6actinfilamentorganizationbrushborderassemblycelldifferentiationsensoryorgandevelopmentsensoryperceptionofsoundvesicletransportalongactinfilament
Activin receptor type-1
6.0
51
59
ACVR1ACVR1Q04771Q04771activinreceptorsignalingpathwayacuteinflammatoryresponseatrialseptumprimummorphogenesisatrioventricularvalvemorphogenesisBMPsignalingpathwayBMPsignalingpathwayinvolvedinheartdevelopmentbranchinginvolvedinbloodvesselmorphogenesiscardiacmusclecellfatecommitmentcellularresponsetoBMPstimuluscellularresponsetoglucocorticoidstimuluscellularresponsetogrowthfactorstimulusdeterminationofleft/rightsymmetrydorsal/ventralpatternformationembryonichearttubemorphogenesisendocardialcushioncellfatecommitmentendocardialcushionfusionendocardialcushionmorphogenesisgastrulationwithmouthformingsecondgermcelldevelopmentheartdevelopmentinuteroembryonicdevelopmentmesodermformationmitralvalvemorphogenesisnegativeregulationofactivinreceptorsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofsignaltransductionneuralcrestcellmigrationpathway-restrictedSMADproteinphosphorylationpeptidyl-threoninephosphorylationpharyngealsystemdevelopmentpositiveregulationofbonemineralizationpositiveregulationofcellmigrationpositiveregulationofdeterminationofdorsalidentitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationpositiveregulationofosteoblastdifferentiationpositiveregulationofpathway-restrictedSMADproteinphosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofossificationregulationofskeletalmuscletissuedevelopmentsmoothmusclecelldifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayurogenitalsystemdevelopmentventricularseptummorphogenesis
Inositol-trisphosphate 3-kinase C
6.0
45
62
✔
IP3KCIP3KCQ9Y475Q9Y475cellularresponsetocalciumioninositolphosphatebiosyntheticprocessphosphatidylinositolphosphatebiosyntheticprocessphosphorylation
Grainyhead-like protein 1 homolog
6.0
83
47
GRHL1GRHL1Q9NZI5Q9NZI5desmosomeorganizationepidermisdevelopmentestablishmentofskinbarrierpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofkeratinocytedifferentiationregulationoftranscriptionbyRNApolymeraseII
Endonuclease V
6.0
69
58
ENDOVENDOVQ8N8Q3Q8N8Q3DNArepair
Thyroxine-binding globulin
6.0
45
60
THBGTHBGP05543P05543negativeregulationofendopeptidaseactivitythyroidhormonetransport
APC variant protein
6.0
58
57
Q4LE70Q4LE70Q4LE70Q4LE70negativeregulationofWntsignalingpathwayWntsignalingpathway
G-protein coupled receptor 183
2.0
52
86
GP183GP183P32249P32249adaptiveimmuneresponseBcellactivationinvolvedinimmuneresponsedendriticcellchemotaxisdendriticcellhomeostasisGprotein-coupledreceptorsignalingpathwayhumoralimmuneresponseimmuneresponseleukocytechemotaxismatureBcelldifferentiationinvolvedinimmuneresponseosteoclastdifferentiationpositiveregulationofBcellproliferationpositiveregulationofERK1andERK2cascaderegulationofastrocytechemotaxisTcellchemotaxisTfollicularhelpercelldifferentiation
Mitogen-activated protein kinase kinase kinase 1
6.1
86
48
M3K1M3K1Q13233Q13233cellularresponsetomechanicalstimulusFc-epsilonreceptorsignalingpathwayproteinphosphorylation
Retinoblastoma-like protein 1
6.1
89
43
RBL1RBL1P28749P28749cellcyclecelldifferentiationchromatinorganizationnegativeregulationofcellularsenescencenegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoflipidkinaseactivity
Thymidine phosphorylase
6.1
80
53
TYPHTYPHP19971P19971angiogenesiscelldifferentiationchemotaxisdTMPcatabolicprocessmitochondrialgenomemaintenancepyrimidinenucleobasemetabolicprocesspyrimidinenucleosidemetabolicprocessregulationofgastricmotilityregulationofmyelinationregulationoftransmissionofnerveimpulse
Cyclin-H
7.1
69
48
CCNHCCNHP51946P51946cellcyclephosphorylationofRNApolymeraseIIC-terminaldomainproteinstabilizationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofG1/StransitionofmitoticcellcycleregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoter
Kanadaptin
6.1
50
66
NADAPNADAPQ9BWU0Q9BWU0
Cytotoxic granule associated RNA binding protein TIA1
3.7
81
74
TIA1TIA1P31483P31483apoptoticprocessmRNAprocessingnegativeregulationofcytokineproductionnegativeregulationoftranslationproteinlocalizationtocytoplasmicstressgranuleregulationofalternativemRNAsplicingviaspliceosomeregulationofmRNAsplicingviaspliceosomeRNAsplicingstressgranuleassembly
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
6.1
60
58
✔
TAF5LTAF6LO75529Q9Y6J9histoneacetylationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofDNA-templatedtranscriptionregulationofRNAsplicingregulationofsomaticstemcellpopulationmaintenanceregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIIchromatinremodelingRNApolymeraseIIpreinitiationcomplexassembly
Myocyte-specific enhancer factor 2A
6.1
70
52
MEF2AMEF2AQ02078Q02078apoptoticprocesscardiacconductioncelldifferentiationcellularresponsetocalciumiondendritemorphogenesisDNA-templatedtranscriptionERK5cascadeheartdevelopmentMAPKcascademitochondrialgenomemaintenancemitochondriondistributionmuscleorgandevelopmentnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcardiacmusclehypertrophypositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIventricularcardiacmyofibrilassembly
E3 ubiquitin-protein ligase SMURF1
6.1
65
57
SMUF1SMUF1Q9HCE7Q9HCE7BMPsignalingpathwaycelldifferentiationectodermdevelopmentengulfmentoftargetbyautophagosomenegativeregulationofBMPsignalingpathwaynegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofaxonextensionpositiveregulationofdendriteextensionpositiveregulationofubiquitin-dependentproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinexportfromnucleusproteinlocalizationtocellsurfaceproteinlocalizationtoplasmamembraneproteinpolyubiquitinationproteintargetingtovacuoleinvolvedinautophagyproteinubiquitinationreceptorcatabolicprocesssubstratelocalizationtoautophagosomeubiquitin-dependentproteincatabolicprocessubiquitin-dependentSMADproteincatabolicprocessWntsignalingpathwayplanarcellpolaritypathway
Nicotinamide N-methyltransferase
6.1
80
50
NNMTNNMTP40261P40261animalorganregenerationmethylationNADbiosynthesisvianicotinamideribosidesalvagepathwaynicotinamidemetabolicprocesspositiveregulationofgluconeogenesispositiveregulationofproteindeacetylationregulationofhistoneH3-K4methylationregulationofhistonemethylationregulationofpolyaminebiosyntheticprocessresponsetoorganonitrogencompoundresponsetoxenobioticstimulus
Cyclin K
6.1
97
40
G3V5E1G3V5E1G3V5E1G3V5E1regulationoftranscriptionbyRNApolymeraseII
Mediator of RNA polymerase II transcription subunit 1
6.1
76
50
MED1MED1Q15648Q15648androgenbiosyntheticprocessangiogenesisanimalorganregenerationbraindevelopmentcellmorphogenesiscellularresponsetoepidermalgrowthfactorstimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetosteroidhormonestimuluscellularresponsetothyroidhormonestimulusembryonichearttubedevelopmentembryonichemopoiesisembryonichindlimbmorphogenesisembryonicplacentadevelopmentenucleateerythrocytedevelopmentepithelialcellproliferationinvolvedinmammaryglandductelongationerythrocytedevelopmentfatcelldifferentiationG0toG1transitionhematopoieticstemcelldifferentiationintracellularsteroidhormonereceptorsignalingpathwaykeratinocytedifferentiationlactationlensdevelopmentincamera-typeeyeliverdevelopmentmammaryglandbranchinginvolvedinpregnancymammaryglandbranchinginvolvedinthelarchemegakaryocytedevelopmentmonocytedifferentiationmRNAtranscriptionbyRNApolymeraseIInegativeregulationofapoptoticprocessnegativeregulationofkeratinocyteproliferationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationoferythrocytedifferentiationpositiveregulationofG0toG1transitionpositiveregulationofgeneexpressionpositiveregulationofhepatocyteproliferationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofkeratinocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIpositiveregulationoftypeIIinterferon-mediatedsignalingpathwayproteinimportintonucleusregulationofRNAbiosyntheticprocessregulationoftranscriptionbyRNApolymeraseIIregulationofvitaminDreceptorsignalingpathwayretinalpigmentepitheliumdevelopmentRNApolymeraseIIpreinitiationcomplexassemblythyroidhormonegenerationthyroidhormonemediatedsignalingpathwayventriculartrabeculamyocardiummorphogenesis
Phospholipid hydroperoxide glutathione peroxidase
3.9
44
78
GPX4GPX4P36969P36969agingarachidonicacidmetabolicprocesschromatinorganizationglutathionemetabolicprocesslipoxygenasepathwaylong-chainfattyacidbiosyntheticprocessnegativeregulationofferroptosisphospholipidmetabolicprocessproteinpolymerizationregulationofinflammatoryresponseresponsetoestradiolresponsetooxidativestressspermatogenesis
TBC1 domain family member 14
6.1
58
58
TBC14TBC14Q9P2M4Q9P2M4activationofGTPaseactivityautophagynegativeregulationofautophagyrecyclingendosometoGolgitransportregulationofautophagosomeassembly
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial
6.1
86
51
ETFDETFDP55931P55931electrontransportchainresponsetooxidativestress
Testis-specific chromodomain protein Y 1
6.1
81
51
CDY1CDY1Q9Y6F8Q9Y6F8spermatogenesis
Nucleoside diphosphate-linked moiety X motif 6
6.1
55
64
NUDT6NUDT6P53370P53370negativeregulationofcellcyclenegativeregulationofcellpopulationproliferation
Ephrin type-A receptor 1
6.1
59
58
EPHA1EPHA1P21709P21709activationofGTPaseactivityangiogenesisaxonguidancecellsurfacereceptorsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofproteinkinaseactivitypeptidyl-tyrosinephosphorylationpositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationofkinaseactivitypositiveregulationofstressfiberassemblyproteinautophosphorylationregulationofGTPaseactivitysubstrateadhesion-dependentcellspreadingtransmembranereceptorproteintyrosinekinasesignalingpathway
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
7.8
93
45
A0A835ZPN7W5NRY1A0A835ZPN7W5NRY1
Aconitate hydratase, mitochondrial
6.2
94
46
✔
ACONACONP16276P16276tricarboxylicacidcycle
39S ribosomal protein L43, mitochondrial isoform X2
6.1
43
64
F1S8U4F1S8U4F1S8U4F1S8U4mitochondrialtranslation
Proteasome subunit beta type-7
6.1
72
44
PSB7PSB3P70195Q9R1P1proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
Transcription initiation factor TFIID subunit 5
6.1
72
54
TAF5TAF5Q15542Q15542DNA-templatedtranscriptioninitiationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationmRNAtranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinphosphorylationregulationofDNArepairregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptioninitiationatRNApolymeraseIIpromoter
Anaphase-promoting complex subunit 4
7.8
65
48
APC4APC4Q9UJX5Q9UJX5anaphase-promotingcomplex-dependentcatabolicprocesscellcyclecelldivisionproteinK11-linkedubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransition
Aldehyde dehydrogenase 1A1
6.1
83
41
AL1A1AL1A1P51977P51977cellulardetoxificationofaldehydefructosaminecatabolicprocessgamma-aminobutyricacidbiosyntheticprocessmaintenanceoflenstransparencyretinoidmetabolicprocessretinolmetabolicprocess
Neuronal PAS domain-containing protein 4
6.1
70
50
NPAS4NPAS4Q8BGD7Q8BGD7celldifferentiationcellularresponsetocorticosteronestimulusexcitatorypostsynapticpotentialinhibitorypostsynapticpotentialinhibitorysynapseassemblylearninglong-termmemorypositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsynapticplasticityregulationofsynaptictransmissionGABAergicregulationoftranscriptionbyRNApolymeraseIIshort-termmemorysocialbehavior
Phosphoinositide 3-kinase regulatory subunit 5
3.4
56
76
PK3CGPI3R5P48736O02696adaptiveimmuneresponseangiogenesiscellmigrationcellularresponsetocAMPdendriticcellchemotaxisendocytosisGprotein-coupledreceptorsignalingpathwayhepatocyteapoptoticprocessimmuneresponseinflammatoryresponseinnateimmuneresponsemastcelldegranulationnaturalkillercellchemotaxisnegativeregulationofcardiacmusclecontractionnegativeregulationoffibroblastapoptoticprocessnegativeregulationoftriglyceridecatabolicprocessneutrophilchemotaxisneutrophilextravasationphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-3-phosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationplateletaggregationpositiveregulationofacuteinflammatoryresponsepositiveregulationofcytokineproductionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofendothelialcellmigrationpositiveregulationofMAPkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofRacproteinsignaltransductionproteinphosphorylationregulationofcalciumiontransmembranetransportregulationofcelladhesionmediatedbyintegrinrespiratoryburstinvolvedindefenseresponsesecretorygranulelocalizationsphingosine-1-phosphatereceptorsignalingpathwayTcellactivationTcellchemotaxisTcellproliferation
Histone H3.3
6.1
82
47
✔
H33H33P84244P84244cellpopulationproliferationembryoimplantationmalegonaddevelopmentmulticellularorganismgrowthmusclecelldifferentiationnegativeregulationofchromosomecondensationnucleusorganizationoocytematurationoogenesisosteoblastdifferentiationpericentricheterochromatinformationregulationofcentromerecomplexassemblysinglefertilizationspermatiddevelopmentspermatogenesissubtelomericheterochromatinformation
Kynurenine 3-monooxygenase
6.0
nan
58
KMOKMOO15229O15229"denovoNADbiosyntheticprocessfromtryptophan"aginganthranilatemetabolicprocesscellularresponsetointerleukin-1cellularresponsetolipopolysaccharidekynurenicacidbiosyntheticprocesskynureninemetabolicprocessL-kynureninemetabolicprocessNADmetabolicprocesspositiveregulationofglutamatesecretionneurotransmissionpositiveregulationofneurondeathquinolinatebiosyntheticprocessresponsetosaltstresstryptophancatabolicprocess
Solute carrier family 40 member
6.2
64
55
A0A1U7U6F1A0A1U7U6F1A0A1U7U6F1A0A1U7U6F1cellularironionhomeostasis
E3 ubiquitin-protein ligase HECTD1
6.2
50
65
HECD1HECD1Q9ULT8Q9ULT8anatomicalstructuredevelopmentaortadevelopmentheartvalvedevelopmentnaturalkillercelldifferentiationnegativeregulationofproteinlocalizationtoplasmamembraneneuraltubeclosurepositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteinK63-linkedubiquitinationproteinlocalizationtoplasmamembraneproteinpolyubiquitinationspongiotrophoblastdifferentiationtrophoblastgiantcelldifferentiationventricularseptumdevelopment
F-box/WD repeat-containing protein 7
6.2
101
38
FBXW7FBXW7Q969H0Q969H0cellularresponsetoDNAdamagestimuluscellularresponsetoUVDNArepairlipidhomeostasislungdevelopmentnegativeregulationofgeneexpressionnegativeregulationofhepatocyteproliferationnegativeregulationofNotchsignalingpathwaynegativeregulationofosteoclastdevelopmentnegativeregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbindingnegativeregulationofSREBPsignalingpathwaynegativeregulationoftriglyceridebiosyntheticprocessNotchsignalingpathwaypositiveregulationofepidermalgrowthfactor-activatedreceptoractivitypositiveregulationofERK1andERK2cascadepositiveregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaypositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteintargetingtomitochondrionpositiveregulationofproteinubiquitinationpositiveregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofubiquitin-proteintransferaseactivityproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindestabilizationproteinstabilizationproteinubiquitinationregulationofautophagyofmitochondrionregulationofcellcycleG1/SphasetransitionregulationofcellmigrationinvolvedinsproutingangiogenesisregulationofcircadianrhythmregulationoflipidstorageregulationofproteinlocalizationrhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocesssisterchromatidcohesionubiquitinrecyclingvasculaturedevelopmentvasculogenesis
N-alpha-acetyltransferase 35, NatC auxiliary subunit
6.2
76
51
NAA35NAA35Q5VZE5Q5VZE5N-terminalpeptidyl-methionineacetylationN-terminalproteinaminoacidacetylationnegativeregulationofapoptoticprocesssmoothmusclecellproliferation
Nuclear receptor ROR-alpha
6.2
69
56
RORARORAP35398P35398angiogenesiscellularresponsetohypoxiacellularresponsetointerleukin-1cellularresponsetosterolcellularresponsetotumornecrosisfactorcerebellargranulecellprecursorproliferationcerebellarPurkinjecelldifferentiationcGMPmetabolicprocesscholesterolhomeostasiscircadianregulationofgeneexpressionintracellularreceptorsignalingpathwaymusclecelldifferentiationnegativeregulationoffatcelldifferentiationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenitricoxidebiosyntheticprocesspositiveregulationofcircadianrhythmpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialgrowthfactorproductionregulationofDNA-templatedtranscriptionregulationofglucosemetabolicprocessregulationofmacrophageactivationregulationofsmoothenedsignalingpathwayregulationofsteroidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIT-helper17celldifferentiationtriglyceridehomeostasisxenobioticmetabolicprocess
Alpha-2B adrenergic receptor
2.0
nan
94
ADA2BADA2BP18089P18089activationofproteinkinaseBactivityadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadrenergicreceptorsignalingpathwayangiogenesiscell-cellsignalingfemalepregnancyGprotein-coupledreceptorsignalingpathwayMAPKcascadenegativeregulationofepinephrinesecretionnegativeregulationofnorepinephrinesecretionplateletactivationpositiveregulationofbloodpressurepositiveregulationofMAPKcascadepositiveregulationofneurondifferentiationpositiveregulationofuterinesmoothmusclecontractionreceptortransactivationregulationofvascularassociatedsmoothmusclecontraction
ATP-dependent DNA helicase Q4
3.7
46
87
✔
RECQ4RECQ4O94761O94761DNAduplexunwindingDNArecombinationDNArepairDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviahomologousrecombinationtelomeremaintenancetelomericD-loopdisassembly
Thioredoxin-related transmembrane protein 1
6.2
45
69
TMX1TMX1Q9H3N1Q9H3N1responsetoendoplasmicreticulumstress
Protoporphyrinogen oxidase
6.2
82
48
✔
PPOXPPOXP50336P50336hemebiosyntheticprocessporphyrin-containingcompoundbiosyntheticprocessprotoporphyrinogenIXbiosyntheticprocess
Vacuolar protein-sorting-associated protein 36
6.2
48
63
VPS36VPS36Q86VN1Q86VN1macroautophagymembranefissionmultivesicularbodyassemblyproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
2-5A-dependent ribonuclease
6.2
67
52
RN5ARN5AQ05823Q05823defenseresponsetovirusfatcelldifferentiationmRNAprocessingnegativeregulationofviralgenomereplicationpositiveregulationofglucoseimportpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofmRNAstabilityRNAprocessingrRNAprocessing
Gamma-tubulin complex component 4
6.2
65
59
GCP4GCP4Q9UGJ1Q9UGJ1cytoplasmicmicrotubuleorganizationmeioticcellcyclemicrotubulenucleationmitoticcellcycleprotein-containingcomplexassemblyspindleassembly
Dynein axonemal assembly factor 10
6.2
90
46
DAA10DAA10Q96MX6Q96MX6apoptoticprocessaxonemaldyneincomplexassemblyproteinstabilization
Inactive tyrosine-protein kinase PEAK1
4.1
71
72
PEAK1PEAK1Q9H792Q9H792cellmigrationfocaladhesionassemblyproteinautophosphorylationproteinphosphorylationregulationoffocaladhesionassemblysubstrateadhesion-dependentcellspreading
V-type proton ATPase 116 kDa subunit a 1
6.2
67
55
VPP1VPP1P25286P25286regulationofmacroautophagysynapticvesiclelumenacidificationtoxintransportvacuolaracidification
NCK-interacting protein with SH3 domain
6.2
78
55
SPN90SPN90Q9NZQ3Q9NZQ3cytoskeletonorganizationendocytosispositiveregulationofneuronprojectiondevelopment
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
6.2
83
49
PDE7APDE7AQ13946Q13946cAMPcatabolicprocesscAMP-mediatedsignalingsignaltransduction
Aflatoxin B1 aldehyde reductase member 2
8.5
58
50
ARK72ARK72O43488O43488carbohydratemetabolicprocesscellularaldehydemetabolicprocessdaunorubicinmetabolicprocessdoxorubicinmetabolicprocesslipidmetabolicprocess
Exosome component 10
6.2
58
61
EXOSXEXOSXQ01780Q01780CUTcatabolicprocessdosagecompensationbyinactivationofXchromosome"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"histonemRNAcatabolicprocessmaturationof5.8SrRNAnegativeregulationoftelomeremaintenanceviatelomerasenuclearmRNAsurveillancenuclearpolyadenylation-dependentantisensetranscriptcatabolicprocessnuclearpolyadenylation-dependentCUTcatabolicprocessnuclearpolyadenylation-dependentrRNAcatabolicprocessnuclearpolyadenylation-dependentsnoRNAcatabolicprocessnuclearpolyadenylation-dependentsnRNAcatabolicprocessnuclearpolyadenylation-dependenttRNAcatabolicprocessnuclear-transcribedmRNAcatabolicprocessnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecay"polyadenylation-dependentsnoRNA3-endprocessing"regulationoftelomeraseRNAlocalizationtoCajalbodyRNAcatabolicprocessRNAprocessingrRNAprocessing
Eukaryotic translation initiation factor 2D
6.6
19
65
EIF2DEIF2DP41214P41214formationoftranslationpreinitiationcomplexintracellularproteintransportIRES-dependentviraltranslationalinitiationribosomedisassembly
Tyrosine-protein kinase
6.4
46
66
B1ASP2B1ASP2B1ASP2B1ASP2interleukin-2-mediatedsignalingpathwayintracellularsignaltransductionpositiveregulationofhomotypiccell-celladhesionpositiveregulationofsproutingangiogenesisproteinlocalizationtocell-celljunctionreceptorsignalingpathwayviaJAK-STATresponsetoantibiotictypeIinterferon-mediatedsignalingpathwaytypeIIinterferon-mediatedsignalingpathway
26S proteasome non-ATPase regulatory subunit 11
6.2
75
50
PSD11PSD11F1LMZ8F1LMZ8proteasomeassemblystemcelldifferentiationubiquitin-dependentproteincatabolicprocess
Guanine deaminase
6.2
84
53
GUADGUADQ9Y2T3Q9Y2T3allantoinmetabolicprocessamidecatabolicprocessdeoxyguanosinecatabolicprocessdGMPcatabolicprocessGMPcatabolicprocessguaninecatabolicprocessguaninemetabolicprocessnervoussystemdevelopmentnucleobase-containingcompoundmetabolicprocess
Transcription activator BRG1
6.2
63
60
SMCA4SMCA4P51532P51532chromatinremodelingnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuralretinadevelopmentnucleosomedisassemblypositiveregulationbyhostofviraltranscriptionpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofglucosemediatedsignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseIpositiveregulationofWntsignalingpathwayregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIpreinitiationcomplexassembly
Isoform 3 of Endonuclease III-like protein 1
6.2
57
64
✔
NTHNTHP78549-3P78549-3
Histone H3.2
6.2
79
46
✔
H32H32Q71DI3Q71DI3nucleosomeassembly
mRNA export factor RAE1
6.9
93
43
RAE1LRAE1LP78406P78406cellcyclecelldivisioncellularresponsetoorganiccycliccompoundmRNAexportfromnucleusnucleocytoplasmictransportregulationofmitoticspindleorganizationRNAexportfromnucleustranscription-dependenttetheringofRNApolymeraseIIgeneDNAatnuclearperiphery
Synaptic vesicle membrane protein VAT-1 homolog-like
6.2
105
43
VAT1LVAT1LQ9HCJ6Q9HCJ6
NNMT protein
6.2
78
49
Q6FH49Q6FH49Q6FH49Q6FH49animalorganregenerationmethylationnicotinamidemetabolicprocesspositiveregulationofgluconeogenesispositiveregulationofproteindeacetylationregulationofhistoneH3-K4methylationregulationofpolyaminebiosyntheticprocessresponsetoorganonitrogencompoundresponsetoxenobioticstimulus
Sodium-coupled monocarboxylate transporter 1
2.0
39
88
SC5A8SC5A8Q8N695Q8N695apoptoticprocessiontransportNADbiosynthesisvianicotinamideribosidesalvagepathwaypropanoatetransportsodiumiontransport
Coatomer subunit beta'
6.2
98
48
COPB2COPB2P35606P35606endoplasmicreticulumtoGolgivesicle-mediatedtransportintra-Golgivesicle-mediatedtransportintracellularproteintransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumtoxintransport
Pentatricopeptide repeat domain-containing protein 3, mitochondrial
6.2
68
50
PTCD3PTCD3Q96EY7Q96EY7mitochondrialtranslationregulationoftranslation
Microcephalin
6.8
66
53
MCPH1MCPH1Q8NEM0Q8NEM0bonedevelopmentcerebralcortexdevelopmentestablishmentofmitoticspindleorientationmitoticcellcyclenegativeregulationoftranscriptionbyRNApolymeraseIIneuronalstemcellpopulationmaintenanceproteinlocalizationtocentrosomeregulationofcentrosomecycleregulationofchromosomecondensationregulationofinflammatoryresponseregulationofkinaseactivity
Kinesin-like protein KIF1A
6.2
65
55
KIF1AKIF1AQ12756Q12756anterogradeaxonaltransportanterogradeneuronaldensecorevesicletransportcytoskeleton-dependentintracellulartransportdensecoregranulecytoskeletaltransportmicrotubule-basedmovementregulationofdendriticspinedevelopmentregulationofdendriticspinemorphogenesisretrogradeneuronaldensecorevesicletransportvesicle-mediatedtransport
Histone-arginine methyltransferase CARM1
7.7
58
51
CARM1CARM1Q4AE70Q4AE70agingcellpopulationproliferationchromatinorganizationDNA-templatedtranscriptionDNA-templatedtranscriptionelongationendochondralbonemorphogenesishistoneargininemethylationhistoneH3-R17methylationhistoneH3-R2methylationhistonemethylationintracellularestrogenreceptorsignalingpathwayintracellularsteroidhormonereceptorsignalingpathwaymRNAprocessingnegativeregulationofdendritedevelopmentnegativeregulationofproteinbindingpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoffatcelldifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtochromatinproteinmethylationregulationofDNA-templatedtranscriptionregulationofgrowthplatecartilagechondrocyteproliferationregulationofintracellularestrogenreceptorsignalingpathwayregulationofmRNAbindingreplicationforkreversalresponsetocAMPRNAsplicing
Exonuclease V
6.2
48
68
EXO5EXO5Q9H790Q9H790interstrandcross-linkrepair
Serine/threonine-protein kinase pim-2
6.2
63
59
PIM2PIM2Q9P1W9Q9P1W9apoptoticprocessG1/StransitionofmitoticcellcyclenegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationpositiveregulationofautophagypositiveregulationofDNA-templatedtranscriptionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingproteinautophosphorylationproteinphosphorylationproteinstabilizationregulationofmitoticcellcycleresponsetovirus
Rho guanine nucleotide exchange factor 9
7.2
nan
58
ARHG9ARHG9Q9QX73Q9QX73receptorclusteringregulationofpostsynapticspecializationassembly
Fidgetin-like protein 1
6.2
53
63
FIGL1FIGL1Q6PIW4Q6PIW4ATPmetabolicprocesscellularresponsetoionizingradiationmalemeioticnucleardivisionnegativeregulationofapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayosteoblastdifferentiationosteoblastproliferationregulationofcellcycleregulationofdouble-strandbreakrepairviahomologousrecombination
Cysteine protease ATG4B
6.2
99
51
✔
ATG4BATG4BQ9Y4P1Q9Y4P1autophagylysosomalmicroautophagymacroautophagymitophagyotolithmineralizationcompletedearlyindevelopmentproteindelipidationproteinlocalizationtophagophoreassemblysiteproteintransportproteolysisselectiveautophagy
pre-mRNA 3' end processing protein WDR33
6.2
97
38
✔
WDR33WDR33Q9C0J8Q9C0J8mRNApolyadenylationpostreplicationrepairspermatogenesis
Eukaryotic translation initiation factor 3 subunit M
6.2
50
60
G1SLW8G1SLW8G1SLW8G1SLW8formationofcytoplasmictranslationinitiationcomplex
Polyunsaturated fatty acid lipoxygenase ALOX12
6.2
63
54
LOX12LOX12P18054P18054arachidonicacidmetabolicprocessestablishmentofskinbarrierfattyacidoxidationhepoxilinbiosyntheticprocessleukotrieneA4metabolicprocesslinoleicacidmetabolicprocesslipidmetabolicprocesslipidoxidationlipoxinA4biosyntheticprocesslipoxinB4biosyntheticprocesslipoxygenasepathwaynegativeregulationofmusclecellapoptoticprocessnegativeregulationofplateletaggregationsuperoxideaniongenerationunsaturatedfattyacidmetabolicprocess
26S proteasome regulatory subunit 7
6.8
53
59
✔
PRS7PRS7P35998P35998osteoblastdifferentiationpositiveregulationofproteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocess
General vesicular transport factor p115
6.3
93
44
✔
USO1USO1P41541P41541endoplasmicreticulumtoGolgivesicle-mediatedtransportGolgivesicledockinginter-Golgicisternavesicle-mediatedtransportintracellularproteintransportmembranefusionproteinhomooligomerizationregulationofcellularresponsetoinsulinstimulussecretorygranulelocalizationsmallGTPasemediatedsignaltransductiontranscytosisvesiclefusionwithGolgiapparatus
BTB/POZ domain-containing protein KCTD16
6.3
86
47
KCD16KCD16Q68DU8Q68DU8proteinhomooligomerizationregulationofGprotein-coupledreceptorsignalingpathway
Nesprin-1
2.1
50
83
SUN1SYNE1O94901Q8NF91centrosomelocalizationhomologouschromosomepairingatmeiosismeioticattachmentoftelomeretonuclearenvelopenuclearenvelopeorganizationnuclearmatrixanchoringatnuclearmembranenucleokinesisinvolvedincellmotilityincerebralcortexradialgliaguidedmigrationspermatogenesisGolgiorganizationmusclecelldifferentiationnucleusorganization
DYNC2H1 variant protein
6.3
50
62
B0I1S0B0I1S0B0I1S0B0I1S0microtubule-basedmovement
Leucine-rich repeat serine/threonine-protein kinase 2
6.3
41
64
LRRK2LRRK2Q5S007Q5S007autophagycalcium-mediatedsignalingcanonicalWntsignalingpathwaycellularresponsetodopaminecellularresponsetomanganeseioncellularresponsetoorganiccycliccompoundcellularresponsetooxidativestresscellularresponsetostarvationdeterminationofadultlifespanendocytosisendoplasmicreticulumorganizationexcitatorypostsynapticpotentialexplorationbehaviorGolgiorganizationGTPmetabolicprocessintracellulardistributionofmitochondriaintracellularsignaltransductionJNKcascadelocomotoryexplorationbehaviorlysosomeorganizationMAPKcascademitochondrionlocalizationmitochondrionorganizationnegativeregulationofautophagosomeassemblynegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofexcitatorypostsynapticpotentialnegativeregulationofGTPaseactivitynegativeregulationofhydrogenperoxide-inducedcelldeathnegativeregulationoflateendosometolysosometransportnegativeregulationofmacroautophagynegativeregulationofneurondeathnegativeregulationofneuronprojectiondevelopmentnegativeregulationofproteinbindingnegativeregulationofproteinphosphorylationnegativeregulationofproteinprocessingnegativeregulationofproteinprocessinginvolvedinproteintargetingtomitochondrionnegativeregulationofproteintargetingtomitochondrionnegativeregulationofthioredoxinperoxidaseactivitybypeptidyl-threoninephosphorylationneuromuscularjunctiondevelopmentneurondeathneuronprojectionarborizationneuronprojectionmorphogenesisolfactorybulbdevelopmentpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationphosphorylationpositiveregulationofautophagypositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofdopaminereceptorsignalingpathwaypositiveregulationofhistonedeacetylaseactivitypositiveregulationofMAPkinaseactivitypositiveregulationofmicroglialcellactivationpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofprogrammedcelldeathpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinautoubiquitinationpositiveregulationofproteinbindingpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofsynapticvesicleendocytosispositiveregulationoftumornecrosisfactorproductionproteinautophosphorylationproteinimportintonucleusproteinlocalizationproteinlocalizationtoendoplasmicreticulumexitsiteproteinlocalizationtomitochondrionproteinphosphorylationreactiveoxygenspeciesmetabolicprocessregulationofautophagyregulationofbranchingmorphogenesisofanerveregulationofCAMKK-AMPKsignalingcascaderegulationofcanonicalWntsignalingpathwayregulationofdendriticspinemorphogenesisregulationofdopaminereceptorsignalingpathwayregulationofERtoGolgivesicle-mediatedtransportregulationofkidneysizeregulationoflocomotionregulationoflysosomallumenpHregulationofmembranepotentialregulationofmitochondrialdepolarizationregulationofmitochondrialfissionregulationofneuroblastproliferationregulationofneurondeathregulationofneuronmaturationregulationofproteinkinaseAsignalingregulationofproteinstabilityregulationofretrogradetransportendosometoGolgiregulationofsynaptictransmissionglutamatergicregulationofsynapticvesicleexocytosisregulationofsynapticvesicletransportresponsetooxidativestresssignaltransductionspermatogenesisstriatumdevelopmenttangentialmigrationfromthesubventricularzonetotheolfactorybulbWntsignalosomeassembly
Thyrotropin-releasing hormone receptor
6.7
61
57
TRFRTRFRP34981P34981Gprotein-coupledreceptorsignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathway
Origin recognition complex subunit 1
6.3
91
46
ORC1ORC1Q13415Q13415DNAreplicationinitiationmitoticDNAreplicationcheckpointsignaling
3-hydroxyisobutyrate dehydrogenase, mitochondrial
6.3
96
54
3HIDH3HIDHP31937P31937valinecatabolicprocess
Probable ATP-dependent RNA helicase DDX47
6.3
58
58
DDX47DDX47Q9H0S4Q9H0S4extrinsicapoptoticsignalingpathwayviadeathdomainreceptorsmRNAprocessingRNAsplicingrRNAprocessing
Serine/threonine-protein kinase N2
6.3
62
52
PKN2PKN2Q16513Q16513apicaljunctionassemblyapoptoticprocesscelladhesioncellcyclecelldivisioncellprojectionorganizationepithelialcellmigrationintracellularsignaltransductionpeptidyl-serinephosphorylationpositiveregulationofcytokinesispositiveregulationofmitoticcellcyclepositiveregulationofviralgenomereplicationproteinphosphorylationregulationofcellmotilitysignaltransduction
Adenine DNA glycosylase
4.7
nan
86
MUTYHMUTYHQ99P21Q99P21base-excisionrepairDNArepairmismatchrepairnegativeregulationofnecroptoticprocessresponsetooxidativestress
Tubulin beta chain
6.3
74
53
✔
TBB5TBB5P07437P07437celldivisioncytoskeleton-dependentintracellulartransportmicrotubulecytoskeletonorganizationmicrotubule-basedprocessmitoticcellcyclenaturalkillercellmediatedcytotoxicityodontoblastdifferentiationregulationofsynapseorganizationspindleassembly
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12
6.3
84
48
Q5XIC6Q5XIC6Q5XIC6Q5XIC6
Mitochondrial potassium channel ATP-binding subunit
6.3
45
65
MITOSMITOSQ9NUT2Q9NUT2cellvolumehomeostasismitochondrialpotassiumiontransmembranetransportpotassiumiontransmembranetransporttransmembranetransport
U3 small nucleolar RNA-interacting protein 2
6.5
82
53
✔
U3IP2U3IP2O43818O43818rRNAprocessing
Crk-like protein
6.3
37
64
✔
CRKLCRKLP46109P46109acetylcholinereceptorsignalingpathwayactivationofGTPaseactivityanterior/posteriorpatternspecificationBcellapoptoticprocessbloodvesseldevelopmentcellchemotaxiscellmigrationcellularresponsetointerleukin-7cellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetoxenobioticstimuluscerebellarneurondevelopmentcerebralcortexdevelopmentcranialskeletalsystemdevelopmentdendritedevelopmentendothelinreceptorsignalingpathwayestablishmentofcellpolarityfibroblastgrowthfactorreceptorsignalingpathwayhelperTcelldiapedesishippocampusdevelopmentintracellularsignaltransductionJNKcascadelipidmetabolicprocessmalegonaddevelopmentnegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationneuronmigrationoutflowtractmorphogenesisparathyroidglanddevelopmentpharynxdevelopmentpositiveregulationofcellpopulationproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofglialcellmigrationpositiveregulationofproteinphosphorylationpositiveregulationofsubstrateadhesion-dependentcellspreadingpostsynapticspecializationassemblyRasproteinsignaltransductionreelin-mediatedsignalingpathwayregulationofcelladhesionmediatedbyintegrinregulationofcellgrowthregulationofdendritedevelopmentregulationofskeletalmuscleacetylcholine-gatedchannelclusteringregulationofTcellmigrationretinoicacidreceptorsignalingpathwaysignaltransductionsinglefertilizationspermatogenesisTcellreceptorsignalingpathwaythymusdevelopmenturogenitalsystemdevelopment
Pre-mRNA-processing factor 17
6.3
93
46
PRP17PRP17O60508O60508embryonicbraindevelopmentmRNAsplicingviaspliceosome
Peroxisomal biogenesis factor 19
6.3
60
56
PEX19PEX19P40855P40855chaperone-mediatedproteinfoldingestablishmentofproteinlocalizationtoperoxisomenegativeregulationoflipidbindingperoxisomefissionperoxisomemembranebiogenesisperoxisomeorganizationproteinimportintoperoxisomemembraneproteinstabilizationproteintargetingtoperoxisome
Serine/threonine-protein kinase A-Raf
6.3
44
64
✔
ARAFARAFP10398P10398MAPKcascadenegativeregulationofapoptoticprocesspositiveregulationofpeptidyl-serinephosphorylationproteinmodificationprocessproteinphosphorylationregulationofproteasomalubiquitin-dependentproteincatabolicprocessregulationofTORsignaling
Cyclin-dependent kinase 2-associated protein 1
6.3
57
57
CDKA1CDKA1O14519O14519cellcycleDNA-templatedDNAreplicationpositiveregulationofproteinphosphorylation
Sterol regulatory element-binding protein cleavage-activating protein
6.3
49
60
SCAPSCAPQ12770Q12770agingcellularlipidmetabolicprocesscholesterolmetabolicprocessCOPII-coatedvesiclecargoloadingimmuneresponsenegativeregulationofcholesterolbiosyntheticprocesspositiveregulationofcholesterolbiosyntheticprocessregulationofcholesterolbiosyntheticprocessregulationoffattyacidbiosyntheticprocessresponsetohypoxiaresponsetoinsulinSREBPsignalingpathway
Protein Niban 2
5.1
65
65
NIBA2NIBA2Q96TA1Q96TA1axonguidancecelldifferentiationgonadotropinsecretionhypomethylationofCpGislandnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofcellpopulationproliferationnegativeregulationofDNAbiosyntheticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofNotchsignalingpathwaynegativeregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofembryonicdevelopmentpositiveregulationofskeletalmusclefiberdevelopmentpositiveregulationoftranscriptionregulatoryregionDNAbinding
Histone H3
6.3
89
44
A0A2U3ZMZ6A0A2U3ZMZ6A0A2U3ZMZ6A0A2U3ZMZ6
Guanine nucleotide exchange factor VAV3
6.3
59
60
VAV3VAV3Q9UKW4Q9UKW4angiogenesisBcellreceptorsignalingpathwaycellmigrationcellularresponsetoDNAdamagestimulusFc-epsilonreceptorsignalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosisintegrin-mediatedsignalingpathwaylamellipodiumassemblyneutrophilchemotaxisplateletactivationpositiveregulationofBcellproliferationpositiveregulationofcelladhesionpositiveregulationofphosphatidylinositol3-kinaseactivityregulationofcellsizeregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionresponsetoxenobioticstimulussmallGTPasemediatedsignaltransductionvesiclefusion
Synapsin-3
6.4
85
46
SYN3SYN3O14994O14994neurotransmittersecretionregulationofsynaptictransmissionGABAergicsynapticvesicleclustering
Peroxiredoxin-5, mitochondrial
6.4
42
61
✔
PRDX5PRDX5P30044P30044cellredoxhomeostasiscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspecieshydrogenperoxidecatabolicprocessinflammatoryresponseNADPHoxidationnegativeregulationofapoptoticprocessnegativeregulationofoxidoreductaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationofcollagenbiosyntheticprocessreactivenitrogenspeciesmetabolicprocessregulationofapoptosisinvolvedintissuehomeostasisresponsetooxidativestress
Ribonuclease P protein subunit p40
6.5
56
58
RPP40RPP40O75818O75818endonucleolyticcleavageinITS1toseparateSSU-rRNAfrom5.8SrRNAandLSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)endonucleolyticcleavageinvolvedintRNAprocessing"tRNA5-leaderremoval"
39S ribosomal protein L46, mitochondrial
6.4
92
44
F1SRT0F1SRT0F1SRT0F1SRT0
Histone H3.3C
6.4
83
45
H3CH3CQ6NXT2Q6NXT2positiveregulationofcellgrowth
Cytoplasmic aconitate hydratase
6.4
97
47
ACOHCACOHCP21399P21399cellularironionhomeostasiscitratemetabolicprocessintestinalabsorptionpost-embryonicdevelopmentregulationoftranslationresponsetoiron(II)iontricarboxylicacidcycle
Heterogeneous nuclear ribonucleoprotein L
6.4
46
63
F2Z3R2F2Z3R2F2Z3R2F2Z3R2mRNAprocessing
Vacuolar protein sorting-associated protein 28 homolog
6.4
62
50
✔
VPS28VPS28Q9UK41Q9UK41macroautophagymembranefissionmultivesicularbodyassemblynegativeregulationofproteinubiquitinationpositiveregulationofproteincatabolicprocesspositiveregulationofubiquitin-dependentendocytosisproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayviralbuddingviahostESCRTcomplex
Aflatoxin B1 aldehyde reductase member 3
8.7
51
51
ARK73ARK73O95154O95154aflatoxincatabolicprocesscellularaldehydemetabolicprocess
Heat shock protein beta-1
6.4
65
54
HSPB1HSPB1P04792P04792anterogradeaxonalproteintransportcellularresponsetovascularendothelialgrowthfactorstimuluschaperone-mediatedproteinfoldingintracellularsignaltransductionnegativeregulationofapoptoticprocessnegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteinkinaseactivityplateletaggregationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofendothelialcellchemotaxispositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofinterleukin-1betaproductionpositiveregulationoftumornecrosisfactorproductionproteinrefoldingregulationofautophagyregulationofI-kappaBkinase/NF-kappaBsignalingregulationofproteinphosphorylationregulationoftranslationalinitiationresponsetoheatresponsetounfoldedproteinresponsetovirusretinahomeostasis
STE20-like serine/threonine-protein kinase
6.4
93
44
SLKSLKQ9H2G2Q9H2G2apoptoticprocesscytoplasmicmicrotubuleorganizationproteinautophosphorylationproteinphosphorylationregulationofapoptoticprocessregulationofcellmigrationregulationoffocaladhesionassembly
Glutamate receptor 2
2.0
nan
91
GRIA2GRIA2Q9R174Q9R174cellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetoglycinecerebralcortexdevelopmentchemicalsynaptictransmissionestablishmentofproteinlocalizationionotropicglutamatereceptorsignalingpathwaypositiveregulationofsynaptictransmissionproteintetramerizationreceptorinternalizationregulationofreceptorrecyclingregulationofsynaptictransmissionglutamatergicresponsetofungicideresponsetolithiumion
Proliferation-associated protein 2G4
6.4
85
47
PA2G4PA2G4Q9UQ80Q9UQ80negativeregulationofapoptoticprocessnegativeregulationofDNA-templatedtranscriptionpositiveregulationofcelldifferentiationregulationoftranslationrRNAprocessing
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
6.4
58
54
WDR4WDR4P57081P57081cellularresponsetoDNAdamagestimulusRNA(guanine-N7)-methylationtRNAmethylationtRNAmodification
Bromodomain PHD finger transcription factor
6.4
68
54
J3QQQ8J3QQQ8J3QQQ8J3QQQ8regulationoftranscriptionbyRNApolymeraseII
Thyroid hormone receptor alpha
6.4
90
45
THATHAP10827P10827cartilagecondensationcelldifferentiationerythrocytedifferentiationfemalecourtshipbehaviorhormone-mediatedsignalingpathwaylearningormemorymRNAtranscriptionbyRNApolymeraseIInegativeregulationofDNA-templatedtranscriptionnegativeregulationofDNA-templatedtranscriptioninitiationnegativeregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIIossificationpositiveregulationofcold-inducedthermogenesispositiveregulationoffemalereceptivitypositiveregulationofthyroidhormonemediatedsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationofheartcontractionregulationoflipidcatabolicprocessregulationofmyeloidcellapoptoticprocessregulationofthyroidhormonemediatedsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetocoldthyroidglanddevelopmentthyroidhormonemediatedsignalingpathwaytranscriptionbyRNApolymeraseIItypeIpneumocytedifferentiation
Glomulin
6.4
74
52
✔
GLMNGLMNQ92990Q92990cellsurfacereceptorsignalingpathwayepigeneticregulationofgeneexpressionmusclecelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofTcellproliferationneuraltubeclosurepositiveregulationofcytokineproductionpositiveregulationofinterleukin-2productionpositiveregulationofphosphorylationregulationofproteasomalubiquitin-dependentproteincatabolicprocessvasculogenesis
Toll-like receptor 1
6.4
59
56
TLR1TLR1Q15399Q15399cellularresponsetobacteriallipopeptidecellularresponsetotriacylbacteriallipopeptidedetectionoftriacylbacteriallipopeptideimmuneresponseinflammatoryresponseinnateimmuneresponsemacrophageactivationpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationoftoll-likereceptor2signalingpathwaypositiveregulationoftumornecrosisfactorproductionsignaltransductiontoll-likereceptorsignalingpathway
DNA-3-methyladenine glycosylase
6.4
78
44
3MG3MGP29372P29372base-excisionrepairdepurinationDNAdealkylationinvolvedinDNArepair
Survival motor neuron protein
2.1
48
85
SMNSMNQ16637Q16637DNA-templatedtranscriptionterminationnervoussystemdevelopmentspliceosomalcomplexassemblyspliceosomalsnRNPassembly
Tubulin--tyrosine ligase
6.4
68
52
TTLTTLQ8NG68Q8NG68microtubulecytoskeletonorganizationpositiveregulationofmitoticcellcyclepost-translationalproteinmodificationregulationofaxonextensionregulationofmetaphaseplatecongression
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
6.6
95
48
NDUS7NDUS7P42026P42026aerobicrespirationelectrontransportcoupledprotontransportmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassembly
Cullin-2
6.4
66
51
CUL2CUL2Q13617Q13617G1/StransitionofmitoticcellcycleintrinsicapoptoticsignalingpathwayproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Zinc finger FYVE domain-containing protein 9
5.5
65
63
SMAD3ZFYV9P84022O95405activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayactivinreceptorsignalingpathwayadrenalglanddevelopmentanatomicalstructuremorphogenesiscelldifferentiationcell-celljunctionorganizationcellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetovirusdevelopmentalgrowthembryoniccranialskeletonmorphogenesisembryonicforegutmorphogenesisembryonicpatternspecificationendodermdevelopmentextrinsicapoptoticsignalingpathwayheartloopingimmuneresponseimmunesystemdevelopmentinuteroembryonicdevelopmentJNKcascadelensfibercelldifferentiationliverdevelopmentmesodermformationnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclehypertrophyinresponsetostressnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofinflammatoryresponsenegativeregulationoflungbloodpressurenegativeregulationofosteoblastdifferentiationnegativeregulationofosteoblastproliferationnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofwoundhealingnodalsignalingpathwayosteoblastdevelopmentparaxialmesodermmorphogenesispericardiumdevelopmentpositiveregulationofalkalinephosphataseactivitypositiveregulationofbonemineralizationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofchondrocytedifferentiationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofmiRNAtranscriptionpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpositivechemotaxispositiveregulationofproteinimportintonucleuspositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbeta3productionprimarymiRNAprocessingproteinstabilizationregulationofbindingregulationofDNA-templatedtranscriptionregulationofepithelialcellproliferationregulationofimmuneresponseregulationofmiRNAtranscriptionregulationofstriatedmuscletissuedevelopmentregulationoftranscriptionbyRNApolymeraseIIregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationoftransforminggrowthfactorbeta2productionresponsetohypoxiasignaltransductioninvolvedinregulationofgeneexpressionSMADproteincomplexassemblySMADproteinsignaltransductionsomitogenesisTcellactivationthyroidglanddevelopmenttransdifferentiationtransforminggrowthfactorbetareceptorsignalingpathwayuretericbuddevelopmentwoundhealingendocytosisendosomaltransport
SEC14-like protein 2
4.7
nan
74
S14L2S14L2O76054O76054positiveregulationofDNA-templatedtranscriptionregulationofcholesterolbiosyntheticprocess
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
6.4
66
53
DUS2LDUS2LQ9NX74Q9NX74negativeregulationofcelldeathtRNAdihydrouridinesynthesis
Myosin X
6.4
80
45
F1M9V6F1M9V6D3ZZ73D3ZZ73
Tetratricopeptide repeat domain 8
6.4
73
54
F1N4X0F1N4X0F1N4X0F1N4X0axonguidancecamera-typeeyephotoreceptorcelldifferentiationestablishmentofanatomicalstructureorientationestablishmentofepithelialcellapical/basalpolarityestablishmentofplanarpolarityfatcelldifferentiationinnerearreceptorcellstereociliumorganizationmulti-ciliatedepithelialcelldifferentiationmulticellularorganismgrowthnegativeregulationofGTPaseactivitynon-motileciliumassemblyolfactorybulbdevelopmentproteinlocalizationtoplasmamembraneregulationofproteinlocalizationregulationofstressfiberassemblyrenaltubuledevelopmentsensoryperceptionofsmell
2'-5'-oligoadenylate synthase 3
6.4
62
53
OAS3OAS3Q9Y6K5Q9Y6K5defenseresponsetobacteriumdefenseresponsetovirusinnateimmuneresponseMDA-5signalingpathwaynegativeregulationofchemokine(C-Cmotif)ligand5productionnegativeregulationofchemokine(C-X-Cmotif)ligand2productionnegativeregulationofchemokine(C-X-Cmotif)ligand9productionnegativeregulationofIP-10productionnegativeregulationoftypeIinterferon-mediatedsignalingpathwaynegativeregulationofviralgenomereplicationnucleobase-containingcompoundmetabolicprocesspositiveregulationofinterferon-betaproductionpositiveregulationofmonocytechemotacticprotein-1productionpositiveregulationoftumornecrosisfactorproductionregulationofribonucleaseactivityresponsetovirusRIG-Isignalingpathway
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
6.4
91
48
PLCB3PLCB3Q01970Q01970Gprotein-coupledreceptorsignalingpathwaylipidcatabolicprocessphosphatidylinositolmetabolicprocessphosphatidylinositol-mediatedsignalingregulationofsystemicarterialbloodpressure
DAP3 protein
6.4
73
47
A6QQP1A6QQP1A6QQP1A6QQP1apoptoticprocess
THO complex subunit 6 homolog
7.6
62
54
✔
THOC6THOC6Q86W42Q86W42apoptoticprocesscentralnervoussystemdevelopmentmRNAexportfromnucleusmRNAprocessingnegativeregulationofapoptoticprocessRNAsplicingviralmRNAexportfromhostcellnucleus
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
6.4
68
55
RSAD2RSAD2Q8CBB9Q8CBB9CD4-positivealpha-betaTcellactivationCD4-positivealpha-betaTcelldifferentiationdefenseresponsetovirusinnateimmuneresponsenegativeregulationofproteinsecretionnegativeregulationofviralgenomereplicationossificationpositiveregulationofimmuneresponsepositiveregulationofT-helper2cellcytokineproductionpositiveregulationoftoll-likereceptor7signalingpathwaypositiveregulationoftoll-likereceptor9signalingpathwayregulationofossificationresponsetovirus
mRNA-capping enzyme
5.9
66
59
✔
MCE1MCE1O60942O609427-methylguanosinemRNAcappingproteindephosphorylationRNAprocessing
Protein arginine N-methyltransferase 2
6.5
38
65
ANM2ANM2P55345P55345developmentalcellgrowthnegativeregulationofDNA-templatedtranscriptionnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofNF-kappaBtranscriptionfactoractivitypeptidyl-argininemethylationpositiveregulationofapoptoticprocesspositiveregulationofDNA-templatedtranscriptionproteinmethylationregulationofandrogenreceptorsignalingpathwaysignaltransduction
Ubiquitin-conjugating enzyme E2 Z
6.5
57
61
UBE2ZUBE2ZQ9H832Q9H832apoptoticprocessnegativeregulationofapoptoticprocesspositiveregulationofapoptoticprocessubiquitin-dependentproteincatabolicprocess
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
6.5
74
55
ECH1ECH1Q13011Q13011fattyacidbeta-oxidation
Exocyst complex component 8
6.5
75
43
EXOC8EXOC8O54924O54924endosomeorganizationexocytosisextracellularmatrixdisassemblyGolgitoplasmamembranetransportproteinlocalizationproteintransport
THRA protein
6.5
85
45
Q6FH41Q6FH41Q6FH41Q6FH41cartilagecondensationerythrocytedifferentiationfemalecourtshipbehaviorlearningormemorynegativeregulationofDNA-templatedtranscriptionossificationpositiveregulationofcold-inducedthermogenesispositiveregulationoffemalereceptivitypositiveregulationoftranscriptionbyRNApolymeraseIIregulationofheartcontractionregulationoflipidcatabolicprocessregulationofmyeloidcellapoptoticprocessregulationofthyroidhormonemediatedsignalingpathwayresponsetocoldthyroidglanddevelopmenttypeIpneumocytedifferentiation
DCN1-like protein 3
6.5
47
59
DCNL3DCNL3Q8IWE4Q8IWE4negativeregulationofcellgrowthnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofproteinneddylationpositiveregulationofapoptoticprocesspositiveregulationofproteinneddylationpositiveregulationofubiquitin-proteintransferaseactivityproteinneddylationregulationofcellcycleprocessregulationofproteinneddylationresponsetogammaradiationresponsetoUV-C
Sphingosine-1-phosphate lyase 1
6.5
83
49
SGPL1SGPL1O95470O95470androgenmetabolicprocessapoptoticsignalingpathwayceramidemetabolicprocessestrogenmetabolicprocessfacemorphogenesisfattyacidmetabolicprocessfibroblastmigrationhemopoiesiskidneydevelopmentLeydigcelldifferentiationluteinizationplatelet-derivedgrowthfactorreceptorsignalingpathwaypost-embryonicdevelopmentregulationofmulticellularorganismgrowthroofofmouthdevelopmentskeletalsystemmorphogenesisspermatogenesissphingolipidbiosyntheticprocesssphingolipidcatabolicprocessvasculogenesis
Tumor necrosis factor receptor type 1-associated DEATH domain protein
6.5
65
58
TRADDTRADDQ15628Q15628apoptoticprocesscellularresponsetotumornecrosisfactorextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofapoptoticprocesspositiveregulationofcellmigrationpositiveregulationofhairfollicledevelopmentpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingsignaltransductiontumornecrosisfactor-mediatedsignalingpathway
2-aminoethanethiol dioxygenase
6.5
75
52
AEDOAEDOQ96SZ5Q96SZ5cellularresponsetohypoxia
LTB4 receptor
2.0
64
85
Q9WTK1Q9WTK1Q9WTK1Q9WTK1
MIT domain-containing protein 1
6.5
93
43
MITD1MITD1Q8WV92Q8WV92midbodyabscissionmitoticcytokinesisnegativeregulationofproteinbinding
HAUS augmin-like complex subunit 2
6.5
50
62
HAUS2HAUS6Q9NVX0Q7Z4H7celldivisioncentrosomecyclemicrotubulenucleationspindleassemblymicrotubulecytoskeletonorganization
V-type proton ATPase 21 kDa proteolipid subunit c''
9.5
33
44
VATOVATOQ99437Q99437endosomallumenacidificationGolgilumenacidificationintracellularpHreductionlysosomallumenacidificationprotontransmembranetransportregulationofmacroautophagyvacuolaracidification
Kinesin-like protein KIF1C
6.5
65
56
KIF1CKIF1CO43896O43896anterogradeneuronaldensecorevesicletransportcytoskeleton-dependentintracellulartransportmicrotubule-basedmovementretrogradeneuronaldensecorevesicletransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumvesicle-mediatedtransport
NFATC2-interacting protein
6.5
66
62
NF2IPNF2IPQ8NCF5Q8NCF5positiveregulationoftranscriptionbyRNApolymeraseIIproteinsumoylation
Glutamine amidotransferase-like class 1 domain-containing protein 1
7.5
62
50
GALD1GALD1Q8NB37Q8NB37methylglyoxalcatabolicprocesstoD-lactateviaS-lactoyl-glutathione
Speckle targeted PIP5K1A-regulated poly(A) polymerase
4.9
67
67
STPAPSTPAPQ9H6E5Q9H6E5mRNApolyadenylationpre-mRNAcleavagerequiredforpolyadenylation"RNA3-endprocessing"snRNAprocessing"U6snRNA3-endprocessing"
Platelet-activating factor acetylhydrolase IB subunit beta
6.5
96
48
LIS1LIS1P43034P43034acrosomeassemblyactincytoskeletonorganizationadultlocomotorybehaviorameboidal-typecellmigrationauditoryreceptorcelldevelopmentbrainmorphogenesiscerebralcortexdevelopmentcerebralcortexneurondifferentiationchemicalsynaptictransmissioncochleadevelopmentcorpuscallosummorphogenesiscorticalmicrotubuleorganizationestablishmentofcentrosomelocalizationestablishmentofmitoticspindleorientationestablishmentofplanarpolarityofembryonicepitheliumgermcelldevelopmenthippocampusdevelopmentinterneuronmigrationJNKcascadelayerformationincerebralcortexlearningormemorylipidcatabolicprocessmaintenanceofcentrosomelocationmicrotubulecytoskeletonorganizationmicrotubulecytoskeletonorganizationinvolvedinestablishmentofplanarpolaritymicrotubuleorganizingcenterorganizationmicrotubuleslidingmicrotubule-basedprocessmodulationofchemicalsynaptictransmissionmyeloidleukocytemigrationnegativeregulationofJNKcascadenegativeregulationofneuronprojectiondevelopmentneuroblastproliferationneuromuscularprocesscontrollingbalanceneuronmigrationnuclearmembranedisassemblynuclearmigrationosteoclastdevelopmentplateletactivatingfactormetabolicprocesspositiveregulationofaxonextensionpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofdendriticspinemorphogenesispositiveregulationofembryonicdevelopmentpositiveregulationofmitoticcellcycleproteinsecretionradialglia-guidedpyramidalneuronmigrationreelin-mediatedsignalingpathwayregulationofGTPaseactivityregulationofmicrotubulecytoskeletonorganizationretrogradeaxonaltransportstemcelldivisiontransmissionofnerveimpulsevesicletransportalongmicrotubule
TRAF3-interacting protein 1
6.5
61
54
MIPT3MIPT3Q8TDR0Q8TDR0ciliumassemblyintraciliaryanterogradetransportintraciliarytransportkidneydevelopmentmorphogenesisofapolarizedepitheliumnegativeregulationofdefenseresponsetovirusnegativeregulationofproteinphosphorylationnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftypeIinterferonproductionregulationofmicrotubulecytoskeletonorganization
Hyccin
5.2
55
66
HYCCIHYCCIQ9BYI3Q9BYI3myelinationphosphatidylinositolphosphatebiosyntheticprocessproteinlocalizationtoplasmamembrane
Steroid receptor RNA activator 1
6.6
56
63
SRA1SRA1Q9HD15Q9HD15apoptoticprocesscelldifferentiationcellularresponsetoestrogenstimulusnegativeregulationofmyoblastdifferentiationregulationofapoptoticprocessregulationofmitoticcellcycle
F-box/LRR-repeat protein 3
2.0
89
77
CRY2FBXL3Q9R194Q9UKT7circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofDNA-templatedtranscriptionnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofphosphoproteinphosphataseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIproteinimportintonucleusregulationofcircadianrhythmregulationofsodium-dependentphosphatetransportresponsetoactivityresponsetoinsulinresponsetolightstimulusG2/MtransitionofmitoticcellcycleproteindestabilizationproteinubiquitinationregulationofcellcyclerhythmicprocessSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Thyroid hormone receptor, alpha isoform 1 variant
6.6
85
44
Q59FW3Q59FW3Q59FW3Q59FW3
Monocarboxylate transporter 2
6.6
78
51
MOT2MOT2O60669O60669lactatetransmembranetransportmonocarboxylicacidtransportpyruvatetransmembranetransporttransportacrossblood-brainbarrier
Solute carrier family 28 member 3
6.6
114
42
S28A3S28A3Q9HAS3Q9HAS3nucleosidetransmembranetransportpurinenucleobasetransmembranetransportpurinenucleosidetransmembranetransportpyrimidinenucleosidetransportpyrimidine-containingcompoundtransmembranetransporturidinetransportxenobioticmetabolicprocessxenobiotictransmembranetransport
GATOR complex protein DEPDC5
7.9
38
58
DEPD5DEPD5O75140O75140cellularresponsetoaminoacidstarvationintracellularsignaltransductionnegativeregulationofTORsignalingnegativeregulationofTORC1signalingpositiveregulationofautophagy
Serine palmitoyltransferase 2
4.8
59
68
SPTC2SPTC2O15270O15270adiposetissuedevelopmentceramidebiosyntheticprocesspositiveregulationoflipophagysphinganinebiosyntheticprocesssphingolipidbiosyntheticprocesssphingomyelinbiosyntheticprocesssphingosinebiosyntheticprocess
Serine/threonine-protein kinase PAK 1
6.6
72
44
PAK1PAK1Q13153Q13153actincytoskeletonreorganizationapoptoticprocessbranchingmorphogenesisofanepithelialtubecellmigrationcellularresponsetoDNAdamagestimuluschromatinremodelingephrinreceptorsignalingpathwayexocytosisFc-gammareceptorsignalingpathwayinvolvedinphagocytosishepatocytegrowthfactorreceptorsignalingpathwayintracellularsignaltransductionlocalizationnegativeregulationofcellproliferationinvolvedincontactinhibitionneuronprojectionmorphogenesisphosphorylationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofJUNkinaseactivitypositiveregulationofmicrotubulenucleationpositiveregulationofmicrotubulepolymerizationpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofstressfiberassemblyproteinautophosphorylationproteinphosphorylationregulationofactincytoskeletonorganizationregulationofaxonogenesisregulationofMAPKcascadestimulatoryC-typelectinreceptorsignalingpathwaywoundhealing
Telomere repeats-binding bouquet formation protein 2
6.6
67
58
TERB2TERB2Q8NHR7Q8NHR7homologouschromosomepairingatmeiosismeioticattachmentoftelomeretonuclearenvelopemeiotictelomereclustering
Proteasome 26S subunit, ATPase 6
6.6
56
56
A0A087X2I1A0A087X2I1A0A087X2I1A0A087X2I1proteincatabolicprocess
Exportin-4
7.5
61
53
XPO4XPO4Q9ESJ0Q9ESJ0positiveregulationofproteinexportfromnucleusproteinexportfromnucleus
Transketolase
6.6
101
42
TKTTKTP29401P29401glyceraldehyde-3-phosphatebiosyntheticprocesspentose-phosphateshuntpentose-phosphateshuntnon-oxidativebranchregulationofgrowthribosephosphatebiosyntheticprocess
Repressor of RNA polymerase III transcription MAF1 homolog
6.6
53
58
MAF1MAF1Q9H063Q9H063negativeregulationoftranscriptionbyRNApolymeraseInegativeregulationoftranscriptionbyRNApolymeraseIII
XK-related protein 8
6.6
37
66
XKR8XKR8Q9H6D3Q9H6D3apoptoticprocessinvolvedindevelopmentengulfmentofapoptoticcellestablishmentoflocalizationincellneutrophilclearancephosphatidylserineexposureonapoptoticcellsurfacepositiveregulationofmyoblastdifferentiationtoleranceinductiontoselfantigen
Cyclin-T2
6.6
76
48
CCNT2CCNT2O60583O60583cellcyclecelldivisionearlyviraltranscriptionlateviraltranscriptionphosphorylationofRNApolymeraseIIC-terminaldomainserine2residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterphosphorylationofRNApolymeraseIIC-terminaldomainserine5residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinphosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofmusclecelldifferentiationregulationoftranscriptionbyRNApolymeraseIIskeletalmuscletissuedevelopmenttranscriptionbyRNApolymeraseII
5-demethoxyubiquinone hydroxylase, mitochondrial
6.6
81
51
COQ7COQ7Q99807Q99807determinationofadultlifespannegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionregulationofreactiveoxygenspeciesmetabolicprocessubiquinonebiosyntheticprocess
WD repeat-containing protein 18
7.7
75
40
WDR18C9JFV4Q9BV38C9JFV4DNA-templatedDNAreplicationrRNAprocessing
28S ribosomal protein S29, mitochondrial
6.6
76
45
RT29RT29P51398P51398apoptoticsignalingpathwaymitochondrialtranslation
Transcription factor RelB
2.6
61
86
RELBRELBQ8VE46Q8VE46antigenprocessingandpresentationcellularresponsetoosmoticstresscircadianregulationofgeneexpressionI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponselymphocytedifferentiationmyeloiddendriticcelldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofinterferon-betaproductionNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIresponsetocytokineT-helper1celldifferentiationT-helper1typeimmuneresponse
Nuclear pore complex protein Nup155
7.3
38
59
NU155NU155O75694O75694atrialcardiacmusclecellactionpotentialmiRNAprocessingmRNAexportfromnucleusnuclearenvelopeorganizationnucleocytoplasmictransportproteinimportintonucleusproteinlocalizationtonuclearinnermembraneRNAexportfromnucleustranscription-dependenttetheringofRNApolymeraseIIgeneDNAatnuclearperiphery
Serine/threonine-protein kinase PAK 3
6.7
88
43
PAK3PAK3O75914O75914axonogenesiscellularresponsetoorganiccycliccompounddendritedevelopmentdendriticspinemorphogenesisephrinreceptorsignalingpathwayintracellularsignaltransductionpositiveregulationofdendriticspinemorphogenesispositiveregulationofDNAbiosyntheticprocesspositiveregulationoffibroblastmigrationpositiveregulationofneuronapoptoticprocessproteinphosphorylationregulationofactincytoskeletonorganizationregulationofactinfilamentpolymerizationregulationofaxonogenesisregulationofMAPKcascadestimulatoryC-typelectinreceptorsignalingpathwaysynapseorganization
Ketimine reductase mu-crystallin
3.4
86
75
CRYMCRYMO54983O54983mitochondrialtransportnegativeregulationoftranscriptionbyRNApolymeraseIIsensoryperceptionofsoundthyroidhormonemetabolicprocessthyroidhormonetransport
Histone H3.1t
6.6
86
43
H31TH31TQ16695Q16695nucleosomeassembly
Fibronectin type-III domain-containing protein 3A
6.6
71
53
FND3AFND3AQ9Y2H6Q9Y2H6cell-celladhesionfertilizationSertolicelldevelopmentspermatiddevelopment
V-type proton ATPase subunit a
6.6
77
49
F1MJV0F1MJV0F1MJV0F1MJV0
Hematopoietic SH2 domain-containing protein
6.6
62
58
HSH2DHSH2DQ96JZ2Q96JZ2negativeregulationofBcellapoptoticprocessnegativeregulationofmitochondrialdepolarizationsignaltransductionTcellactivation
Fanconi anemia core complex-associated protein 24
6.6
73
49
FAP24FAP24Q9BTP7Q9BTP7interstrandcross-linkrepair
Unconventional myosin-X
6.6
67
57
MYO10MYO10Q9HD67Q9HD67cytoskeleton-dependentintracellulartransportpositiveregulationofcell-celladhesionregulationofcellshaperegulationoffilopodiumassemblysignaltransduction
Proteasome subunit beta type-10
6.6
99
41
PSB10PSB10O35955O35955cellmorphogenesisproteasomalproteincatabolicprocessTcellproliferation
Transcription factor IIIB 50 kDa subunit
6.9
68
51
BRF2BRF2Q9HAW0Q9HAW0cellularresponsetooxidativestressDNA-templatedtranscriptioninitiationregulationoftranscriptionbyRNApolymeraseIIItranscriptionpreinitiationcomplexassembly
Histone deacetylase 3
6.7
79
42
HDAC3HDAC3O15379O15379cellularresponsetofluidshearstresschromatinorganizationcircadianregulationofgeneexpressioncornifiedenvelopeassemblyepidermisdevelopmentestablishmentofskinbarrierhistoneH4-K12deacetylationinuteroembryonicdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclecelldifferentiationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofJNKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcold-inducedthermogenesispositiveregulationofproteinimportintonucleuspositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofTORsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIproteindeacetylationregulationofcircadianrhythmregulationofmitoticcellcycleregulationofmulticellularorganismgrowthregulationofproteinstabilityregulationoftranscriptionbyRNApolymeraseIIspindleassemblytranscriptionbyRNApolymeraseII
Rho-related GTP-binding protein RhoQ
6.7
64
52
RHOQRHOQP17081P17081actincytoskeletonorganizationcellularresponsetoinsulinstimuluscorticalactincytoskeletonorganizationendocytosisestablishmentormaintenanceofcellpolarityGTPmetabolicprocessinsulinreceptorsignalingpathwaynegativeregulationofproteinlocalizationtoplasmamembranepositiveregulationoffilopodiumassemblypositiveregulationofglucoseimportpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofactincytoskeletonorganizationregulationofcellshapesmallGTPasemediatedsignaltransduction
Synapsin-1
6.7
85
46
SYN1SYN1P17599P17599neurotransmittersecretion
IST1 homolog
6.7
67
55
IST1IST1P53990P53990abscissioncelldivisioncollateralsproutingcytoskeleton-dependentcytokinesisESCRTIIIcomplexdisassemblyestablishmentofproteinlocalizationmultivesicularbodyassemblypositiveregulationofcollateralsproutingpositiveregulationofproteolysisproteinlocalizationproteintransportviralcapsidsecondaryenvelopmentviralreleasefromhostcell
M-phase inducer phosphatase 2
6.7
84
48
MPIP2MPIP2P30305P30305celldivisionfemalemeiosisIG2/MtransitionofmitoticcellcyclemitoticcellcycleoocytematurationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokinesispositiveregulationofG2/MtransitionofmitoticcellcyclepositiveregulationofG2/MItransitionofmeioticcellcyclepositiveregulationofmitoticcellcyclepositiveregulationofproteinkinaseactivityproteindephosphorylationproteinphosphorylation
Cytoplasmic dynein 2 heavy chain 1
7.5
55
57
DYHC2DYHC2Q8NCM8Q8NCM8ciliumassemblycoronaryvasculaturedevelopmentdeterminationofleft/rightsymmetrydorsal/ventralpatternformationembryoniclimbmorphogenesisforebraindevelopmentGolgiorganizationintraciliaryretrogradetransportkidneydevelopmentmicrotubule-basedmovementnon-motileciliumassemblypositiveregulationofsmoothenedsignalingpathwayproteinlocalizationtociliumproteinprocessingspinalcordmotorneurondifferentiation
Serine/threonine-protein kinase MARK1
6.7
65
55
MARK1MARK1Q9P0L2Q9P0L2cytoskeletonorganizationestablishmentofmitochondrionlocalizationintracellularsignaltransductionmicrotubulecytoskeletonorganizationnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofgeneexpressionneuronmigrationpeptidyl-serinephosphorylationpositiveregulationofgeneexpressionproteinphosphorylationregulationofdendritedevelopmentregulationofneuronprojectiondevelopmentWntsignalingpathway
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
6.7
55
57
HOGA1HOGA1Q86XE5Q86XE54-hydroxyprolinecatabolicprocessglyoxylatecatabolicprocessglyoxylatemetabolicprocessoxalatemetabolicprocesspyruvatebiosyntheticprocess
Exosome complex component MTR3
6.7
86
47
EXOS6EXOS6Q5RKV6Q5RKV6DNAdeaminationisotypeswitchingnuclearmRNAsurveillance"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5""polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationofisotypeswitchingRNAcatabolicprocessRNAprocessingrRNAcatabolicprocessrRNAprocessing"U4snRNA3-endprocessing"
Rab proteins geranylgeranyltransferase component A 1
4.5
71
73
RAE1RAE1P37727P37727bloodvesseldevelopmentproteingeranylgeranylationproteintargetingtomembranesmallGTPasemediatedsignaltransductionvesicle-mediatedtransport
X-linked retinitis pigmentosa GTPase regulator
6.7
105
46
RPGRRPGRQ92834Q92834ciliumassemblyintracellularproteintransportintraciliarytransportresponsetostimulusvisualperception
[F-actin]-monooxygenase MICAL3
6.7
81
50
MICA3MICA3Q7RTP6Q7RTP6actinfilamentdepolymerizationcellcyclecelldivisioncytoskeletonorganizationexocytosislocalization
Dual specificity protein phosphatase CDC14B
7.2
51
52
CC14BCC14BO60729O60729ciliumassemblyDNArepairmicrotubulecytoskeletonorganizationmitoticG2DNAdamagecheckpointsignalingpositiveregulationofcytokinesispositiveregulationofubiquitinproteinligaseactivityproteindephosphorylationregulationofexitfrommitosis
DNA replication ATP-dependent helicase/nuclease DNA2
6.7
51
61
DNA2DNA2Q6ZQJ5Q6ZQJ5base-excisionrepairDNAdouble-strandbreakprocessingDNAreplicationDNAreplicationcheckpointsignalingDNAreplicationOkazakifragmentprocessingDNAreplicationremovalofRNAprimermitochondrialDNArepairmitochondrialDNAreplicationmitotictelomeremaintenanceviasemi-conservativereplicationnucleicacidphosphodiesterbondhydrolysispositiveregulationofDNAreplicationreplicationforkreversaltelomeremaintenance
X-ray repair cross-complementing protein 5
6.7
64
53
✔
XRCC5XRCC5P13010P13010activationofinnateimmuneresponsebraindevelopmentcellularhyperosmoticsalinityresponsecellularresponsetoDNAdamagestimuluscellularresponsetofattyacidcellularresponsetogammaradiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetoX-rayDNArecombinationdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoininghematopoieticstemcelldifferentiationhematopoieticstemcellproliferationinnateimmuneresponsenegativeregulationofDNA-templatedtranscriptionnegativeregulationoft-circleformationneurogenesispositiveregulationofcatalyticactivitypositiveregulationofneurogenesispositiveregulationofproteinkinaseactivitypositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenanceviatelomeraseproteinlocalizationtochromosometelomericregionrecombinationalrepairregulationofsmoothmusclecellproliferationregulationoftelomeremaintenanceresponsetoxenobioticstimulussmall-subunitprocessomeassemblytelomeremaintenance
WD repeat-containing protein 47
3.9
nan
81
WDR47WDR47Q8CGF6Q8CGF6adultlocomotorybehavioranteriorcommissuremorphogenesisautophagybraindevelopmentcerebralcortexdevelopmentcerebralcortexradialglia-guidedmigrationcorpuscallosumdevelopmentdetectionofhotstimulusinvolvedinthermoceptionlocomotorybehaviormicrotubulecytoskeletonorganizationmotorbehaviornegativeregulationofmicrotubuledepolymerizationneuralprecursorcellproliferationneuronprojectiondevelopmentneuronalstemcellpopulationmaintenance
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
6.0
nan
64
TAF6LATX7Q9Y6J9O15265chromatinremodelinghistoneacetylationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofDNA-templatedtranscriptionregulationofRNAsplicingregulationofsomaticstemcellpopulationmaintenanceregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblymicrotubulecytoskeletonorganizationnegativeregulationofmicrotubuledepolymerizationnucleusorganizationvisualperception
Ammonium transporter Rh type C
6.7
89
47
RHCGRHCGQ9UBD6Q9UBD6aminetransportammoniumhomeostasisammoniumtransmembranetransportcellularionhomeostasisepithelialcelldifferentiationhomeostaticprocessregulationofpHtransepithelialammoniumtransport
Chromodomain Y-like protein
6.7
81
48
CDYLCDYLQ9Y232Q9Y232negativeregulationofpeptidyl-lysinecrotonylationrandominactivationofXchromosomespermatiddevelopmentspermatogenesis
Integrator complex subunit 3
8.4
nan
51
INT3INT3Q68E01Q68E01cellularresponsetoDNAdamagestimulusDNArepairdouble-strandbreakrepairviahomologousrecombinationmitoticG2/MtransitioncheckpointregulationoftranscriptionelongationbyRNApolymeraseIIresponsetoionizingradiationsnRNAprocessing
Xylulose kinase
6.7
78
52
XYLBXYLBO75191O75191carbohydratemetabolicprocessD-xylosemetabolicprocessgenerationofprecursormetabolitesandenergyglucuronatecatabolicprocesstoxylulose5-phosphatephosphorylationxylulosecatabolicprocessxylulosemetabolicprocess
DNA-directed DNA/RNA polymerase mu
6.7
42
66
✔
DPOLMDPOLMQ9NP87Q9NP87DNArecombinationdouble-strandbreakrepairvianonhomologousendjoining
Transcription factor p65
6.7
62
50
TF65TF65Q04206Q04206animalorganmorphogenesiscellulardefenseresponsecellularresponsetoangiotensincellularresponsetohepatocytegrowthfactorstimuluscellularresponsetohydrogenperoxidecellularresponsetointerleukin-1cellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetolipoteichoicacidcellularresponsetonicotinecellularresponsetopeptidoglycancellularresponsetotumornecrosisfactorcellularresponsetovascularendothelialgrowthfactorstimuluschromatinorganizationcytokine-mediatedsignalingpathwaydefenseresponsetotumorcelldefenseresponsetovirushairfollicledevelopmentI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseinterleukin-1-mediatedsignalingpathwayliverdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofmiRNAtranscriptionnegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofproteincatabolicprocessnegativeregulationofproteinsumoylationnegativeregulationoftranscriptionbyRNApolymeraseIIneuropeptidesignalingpathwayNIK/NF-kappaBsignalingnucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofamyloid-betaformationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-8productionpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofmiRNAmetabolicprocesspositiveregulationofmiRNAtranscriptionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinvolvedincellularresponsetochemicalstimuluspostsynapsetonucleussignalingpathwayproteincatabolicprocessregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscriptioninresponsetostressregulationofinflammatoryresponseregulationofNIK/NF-kappaBsignalingregulationoftranscriptionbyRNApolymeraseIIresponsetocytokineresponsetointerleukin-1responsetomuramyldipeptideresponsetomusclestretchresponsetoorganicsubstanceresponsetoUV-Btumornecrosisfactor-mediatedsignalingpathway
Oxidoreductase HTATIP2
6.7
89
43
HTAI2HTAI2O60520O60520angiogenesisapoptoticprocesscelldifferentiationimportintonucleusnegativeregulationofapoptoticprocesspositiveregulationofprogrammedcelldeathpositiveregulationoftranscriptionbyRNApolymeraseIIproteinautophosphorylationregulationofangiogenesisregulationoftranscriptionbyRNApolymeraseII
C-C motif chemokine 19
2.0
43
88
CCL19CCL19Q99731Q99731antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellcommunicationcellmaturationcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferoncellularresponsetoviruschemokine-mediatedsignalingpathwaydendriticcellchemotaxisestablishmentofTcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseimmunologicalsynapseformationinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismatureconventionaldendriticcelldifferentiationmonocytechemotaxismyeloiddendriticcellchemotaxisnegativeregulationofdendriticcellapoptoticprocessneutrophilchemotaxispositiveregulationofcellmotilitypositiveregulationofchemotaxispositiveregulationofdendriticcellantigenprocessingandpresentationpositiveregulationofdendriticcelldendriteassemblypositiveregulationofendocytosispositiveregulationofERK1andERK2cascadepositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofneutrophilchemotaxispositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteinkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellproliferationpositiveregulationofT-helper1celldifferentiationpositiveregulationoftumornecrosisfactorproductionregulationofcellprojectionassemblyreleaseofsequesteredcalciumionintocytosolresponsetonitricoxideresponsetoprostaglandinEresponsetovirusTcellcostimulation
Serine/threonine-protein kinase RIO2
6.8
66
47
RIOK2RIOK2Q9BVS4Q9BVS4cellcyclematurationofSSU-rRNApositiveregulationofribosomalsmallsubunitexportfromnucleuspositiveregulationofrRNAprocessingproteinautophosphorylationregulationofmitoticmetaphase/anaphasetransitionribosomalsmallsubunitbiogenesis
Cystinosin
6.8
50
58
CTNSCTNSO60931O60931adultwalkingbehavioraminoacidmetabolicprocessATPmetabolicprocessbraindevelopmentcognitionglutathionemetabolicprocessgroomingbehavioriontransportL-cystinetransportlensdevelopmentincamera-typeeyelong-termmemorymelaninbiosyntheticprocessnegativeregulationofhydrogenperoxidebiosyntheticprocesspositiveregulationofmitochondrialmembranepotentialpositiveregulationofTORC1signalingproteintransportregulationofmelaninbiosyntheticprocesstransmembranetransportvisuallearning
28S rRNA (cytosine-C(5))-methyltransferase
3.2
63
83
NSUN5NSUN5Q9NW70Q9NW70cerebralcortexdevelopmentcognitioncorpuscallosumdevelopmentoligodendrocytedevelopmentpositiveregulationoftranslationregulationofmyelinationRNAmethylationrRNAbasemethylation
HAUS augmin-like complex subunit 7
7.3
40
61
HAUS7HAUS7Q99871Q99871celldivisioncentrosomecyclespindleassembly
Mitotic-spindle organizing protein 1
6.8
73
50
MZT1MZT1Q08AG7Q08AG7gamma-tubulincomplexlocalizationmicrotubulenucleationbyinterphasemicrotubuleorganizingcentermitoticspindleassembly
Nuclear receptor subfamily 2 group E member 1
6.8
78
47
NR2E1NR2E1Q9Y466Q9Y466aggressivebehavioramygdaladevelopmentanatomicalstructuredevelopmentangiogenesisanteriorcommissuremorphogenesisapoptoticprocessastrocytecellmigrationastrocytedifferentiationbehavioralfearresponsecelldifferentiationcellfatecommitmentcerebralcortexneurondifferentiationdentategyrusdevelopmentextracellularmatrixorganizationforebraingenerationofneuronslayerformationincerebralcortexlong-termsynapticpotentiationnegativeregulationofapoptoticprocessnegativeregulationofastrocytedifferentiationnegativeregulationofneuralprecursorcellproliferationnegativeregulationofneurondifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuroblastproliferationolfactorybulbdevelopmentpositiveregulationofangiogenesispositiveregulationofcellcyclepositiveregulationofneuroblastproliferationpositiveregulationofstemcellproliferationregulationofcellmigrationinvolvedinsproutingangiogenesisregulationofdendritemorphogenesisregulationoftimingofneurondifferentiationregulationoftranscriptionbyRNApolymeraseIIretinadevelopmentincamera-typeeyesocialbehaviorsomaticstemcellpopulationmaintenancevisualperception
Nuclear pore complex protein Nup88
6.8
61
53
NUP88NUP88Q99567Q99567mitoticcellcyclemRNAexportfromnucleusnucleocytoplasmictransportproteinimportintonucleusribosomallargesubunitexportfromnucleusribosomalsmallsubunitexportfromnucleus
Geranylgeranyl transferase type-1 subunit beta
6.9
86
45
PGTB1PGTB1P53610P53610negativeregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationproteingeranylgeranylationproteinprenylationresponsetocytokine
Protein O-GlcNAcase
6.8
64
54
OGAOGAO60502O60502glycoproteincatabolicprocessglycoproteinmetabolicprocessN-acetylglucosaminemetabolicprocessproteindeglycosylationproteinO-linkedglycosylation
Glutaredoxin-related protein 5, mitochondrial
6.8
63
56
✔
GLRX5GLRX5Q86SX6Q86SX62Fe-2Sclusterassemblycellredoxhomeostasishemopoiesisironionhomeostasisiron-sulfurclusterassemblyproteinmaturationby2Fe-2Sclustertransferproteinmaturationby4Fe-4Sclustertransfer
Arylamine N-acetyltransferase 1
6.8
87
51
ARY1ARY1P18440P18440xenobioticmetabolicprocess
UbiA prenyltransferase domain-containing protein 1
6.8
53
56
G3IEF0G3IEF0G3IEF0G3IEF0menaquinonebiosyntheticprocessubiquinonebiosyntheticprocessvitaminKbiosyntheticprocess
ATP-binding cassette sub-family G member 5
2.0
nan
90
ABCG5ABCG5Q9H222Q9H222bileacidsignalingpathwaycholesteroleffluxcholesterolhomeostasisintestinalcholesterolabsorptionnegativeregulationofintestinalcholesterolabsorptionnegativeregulationofintestinalphytosterolabsorptionresponsetoionizingradiationresponsetomuscleactivityresponsetonutrientresponsetoxenobioticstimulussteroltransporttransmembranetransporttriglyceridehomeostasis
Hepatic sodium/bile acid cotransporter
3.6
83
69
NTCPNTCPQ14973Q14973bileacidandbilesalttransportbileacidsignalingpathwaycellularresponsetoxenobioticstimulusregulationofbileacidsecretionregulationofgeneexpressionresponseto17alpha-ethynylestradiolresponsetoethanolresponsetonutrientlevels
T-cell immunoglobulin and mucin domain-containing protein 4
2.0
66
83
TIMD4TIMD4Q6U7R4Q6U7R4apoptoticcellclearancecytoskeletalrearrangementinvolvedinphagocytosisengulfment
Centromere protein L
7.4
61
54
✔
CENPLCENPLQ8N0S6Q8N0S6
SRP receptor subunit alpha
6.8
62
57
A0A5F9CI80A0A5F9CI80A0A5F9CI80A0A5F9CI80SRP-dependentcotranslationalproteintargetingtomembrane
Ras GTPase-activating-like protein IQGAP1
6.8
74
44
IQGA1IQGA1P46940P46940cellmigrationcellularresponsetocalciumioncellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoplatelet-derivedgrowthfactorstimulusepidermalgrowthfactorreceptorsignalingpathwayfibroblastgrowthfactorreceptorsignalingpathwayfibroblastmigrationnegativeregulationofdephosphorylationneuronprojectionextensionplatelet-derivedgrowthfactorreceptorsignalingpathwaypodocytedevelopmentpositiveregulationofMAPKcascadepositiveregulationofproteinkinaseactivityregulationofactincytoskeletonorganizationregulationofcytokineproductionregulationofGTPaseactivityregulationofmitoticcellcyclesignaltransduction
Pleiotropic regulator 1
6.9
101
37
PLRG1PLRG1O43660O43660mRNAsplicingviaspliceosomepositiveregulationofG1/Stransitionofmitoticcellcycleproteinlocalizationtonucleus
Protein MEMO1
7.3
58
54
MEMO1MEMO1Q9Y316Q9Y316regulationofmicrotubule-basedprocess
Probable E3 ubiquitin-protein ligase HERC1
6.8
64
56
HERC1HERC1Q15751Q15751autophagycerebellarPurkinjecelldifferentiationcorpuscallosumdevelopmentnegativeregulationofautophagyneuromuscularprocesscontrollingbalanceneuronprojectiondevelopment
Proteinase-activated receptor 1
2.0
69
83
PAR1PAR1P25116P25116activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessanatomicalstructuremorphogenesiscell-celljunctionmaintenanceconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdendriticcellhomeostasisestablishmentofsynapticspecificityatneuromuscularjunctionGprotein-coupledreceptorsignalingpathwayhomeostasisofnumberofcellswithinatissueinflammatoryresponsenegativeregulationofcellpopulationproliferationnegativeregulationofglomerularfiltrationnegativeregulationofneuronapoptoticprocessnegativeregulationofreninsecretionintobloodstreamphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayplateletactivationplateletdensegranuleorganizationpositiveregulationofbloodcoagulationpositiveregulationofcalciumiontransportpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofMAPKcascadepositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofRhoproteinsignaltransductionpositiveregulationofsmoothmusclecontractionpositiveregulationofvasoconstrictionproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofbloodcoagulationregulationofinterleukin-1betaproductionregulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolresponsetolipopolysaccharideresponsetowoundingtrans-synapticsignalingbyendocannabinoidmodulatingsynaptictransmission
T-complex protein 1 subunit theta
6.8
53
58
✔
TCPQTCPQP50990P50990bindingofspermtozonapellucidachaperone-mediatedproteinfoldingporecomplexassemblypositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationtoxintransport
T-complex protein 1 subunit delta
6.8
95
38
TCPDTCPDP50991P50991bindingofspermtozonapellucidachaperone-mediatedproteinfoldingpositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationoftelomeraseactivitypositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationscaRNAlocalizationtoCajalbodytoxintransport
Three-prime repair exonuclease 1
6.8
86
42
TREX1TREX1Q9NSU2Q9NSU2activationofimmuneresponseapoptoticcellclearanceatrialcardiacmuscletissuedevelopmentbloodvesseldevelopmentCD86biosyntheticprocesscellularresponsetogammaradiationcellularresponsetohydroxyureacellularresponsetointerferon-betacellularresponsetoreactiveoxygenspeciesdefenseresponsetovirusdeterminationofadultlifespanDNAcatabolicprocessexonucleolyticDNAduplexunwindingDNAmetabolicprocessDNAmodificationDNArecombinationDNArepairDNAreplicationDNAsynthesisinvolvedinUV-damageexcisionrepairestablishmentofproteinlocalizationgenerationofprecursormetabolitesandenergyheartmorphogenesisheartprocessimmunecomplexformationimmuneresponseinbrainornervoussysteminflammatoryresponsetoantigenicstimuluskidneydevelopmentlymphoidprogenitorcelldifferentiationmacrophageactivationinvolvedinimmuneresponsemismatchrepairmitoticG1DNAdamagecheckpointsignalingnegativeregulationofinnateimmuneresponsenegativeregulationoftypeIinterferon-mediatedsignalingpathwayproteinstabilizationregulationofcatalyticactivityregulationofcellularrespirationregulationoffattyacidmetabolicprocessregulationofglycolyticprocessregulationofimmunoglobulinproductionregulationofinflammatoryresponseregulationoflipidbiosyntheticprocessregulationoflysosomeorganizationregulationofproteincomplexstabilityregulationofTcellactivationregulationoftumornecrosisfactorproductionregulationoftypeIinterferonproductionTcellantigenprocessingandpresentationtranspositionRNA-mediatedtypeIinterferon-mediatedsignalingpathway
Taste receptor type 2 member 46
6.8
45
57
T2R46T2R46P59540P59540detectionofchemicalstimulusinvolvedinsensoryperceptionofbittertaste
ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a
6.8
109
37
B0K022B0K022B0K022B0K022
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
6.8
95
43
PLCB2PLCB2Q00722Q00722activationofphospholipaseCactivitydetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertasteGprotein-coupledreceptorsignalingpathwaylipidcatabolicprocessphosphatidylinositolmetabolicprocessphosphatidylinositol-mediatedsignalingphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwayphospholipidmetabolicprocess
Proteasome subunit alpha type-4
6.8
100
46
PSA4PSA4P25789P25789proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocess
Anillin
6.8
41
62
ANLNANLNQ9NQW6Q9NQW6actomyosincontractileringassemblyhematopoieticprogenitorcelldifferentiationmitoticcytokinesispodocytecellmigrationpositiveregulationofblebassemblyregulationofexitfrommitosisseptinringassemblyseptinringorganization
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
6.8
55
58
DHSDDHSDA5GZW8A5GZW8mitochondrialelectrontransportsuccinatetoubiquinonetricarboxylicacidcycle
Toll/interleukin-1 receptor domain-containing adapter protein
2.7
nan
89
TIRAPTIRAPP58753P58753"3-UTR-mediatedmRNAstabilization"activationofNF-kappaB-inducingkinaseactivitycellsurfacereceptorsignalingpathwaycellularresponsetobacteriallipopeptidecellularresponsetolipoteichoicaciddefenseresponsetoGram-positivebacteriumI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponseMyD88-dependenttoll-likereceptorsignalingpathwaymyeloidcelldifferentiationpositiveregulationofBcellproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand1productionpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinnateimmuneresponsepositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-15productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofneutrophilchemotaxispositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofprotein-containingcomplexassemblypositiveregulationoftoll-likereceptor2signalingpathwaypositiveregulationoftoll-likereceptor3signalingpathwaypositiveregulationoftoll-likereceptor4signalingpathwaypositiveregulationoftumornecrosisfactorproductionregulationofinnateimmuneresponseregulationofinterferon-betaproductionregulationofstress-activatedMAPKcascaderesponsetolipopolysaccharideTIRAP-dependenttoll-likereceptor4signalingpathway
Sarcolemmal membrane-associated protein
6.8
71
51
SLMAPSLMAPQ14BN4Q14BN4musclecontractionproteinlocalizationtoplasmamembraneregulationofmembranedepolarizationduringcardiacmusclecellactionpotentialregulationofsodiumiontransmembranetransportregulationofvoltage-gatedsodiumchannelactivity
Dihydropyrimidinase-related protein 1
6.8
90
46
DPYL1DPYL1P97427P97427negativeregulationofactinfilamentbindingnegativeregulationofneuronprojectiondevelopmentsemaphorin-plexinsignalingpathway
Nuclear mitotic apparatus protein 1
6.9
54
58
GPSM2NUMA1P81274Q14980celldivisionestablishmentofmitoticspindleorientationGprotein-coupledreceptorsignalingpathwaymaintenanceofcentrosomelocationmitoticspindleorganizationpositiveregulationofproteinlocalizationtocellcortexpositiveregulationofspindleassemblyRanproteinsignaltransductionregulationofmitoticspindleorganizationanastralspindleassemblyastralmicrotubuleorganizationchromosomesegregationmeioticcellcyclemicrotubulebundleformationnucleusorganizationpositiveregulationofBMPsignalingpathwaypositiveregulationofchromosomesegregationpositiveregulationofchromosomeseparationpositiveregulationofhairfollicledevelopmentpositiveregulationofintracellulartransportpositiveregulationofkeratinocytedifferentiationpositiveregulationofmicrotubulepolymerizationpositiveregulationofmitoticspindleelongationpositiveregulationofproteinlocalizationtospindlepolebodyregulationofmetaphaseplatecongression
Rho-related GTP-binding protein RhoG
8.1
63
46
✔
RHOGRHOGP84095P84095actincytoskeletonorganizationactinfilamentorganizationactivationofGTPaseactivitycellchemotaxiscellprojectionassemblycorticalcytoskeletonorganizationengulfmentofapoptoticcellestablishmentormaintenanceofcellpolaritymotorneuronaxonguidancepositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinlocalizationtoplasmamembraneRacproteinsignaltransductionregulationofactincytoskeletonorganizationregulationofcellshaperegulationofneutrophilmigrationregulationofruffleassemblyRhoproteinsignaltransduction
Creatine kinase B-type
7.2
82
48
✔
KCRBKCRBP12277P12277cellularchlorideionhomeostasiscellularresponsetoestrogenstimuluscellularresponsetowortmannincerebellumdevelopmentphosphocreatinebiosyntheticprocessphosphorylationsubstantianigradevelopment
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
6.8
65
50
2ABA2ABAP63151P63151proteindephosphorylationresponsetomorphine
26S proteasome non-ATPase regulatory subunit 12
6.8
67
50
PSD12PSD12O00232O00232proteasome-mediatedubiquitin-dependentproteincatabolicprocess
Ubiquitin-conjugating enzyme E2 W
6.8
nan
63
UBE2WUBE2WQ96B02Q96B02cellularresponsetomisfoldedproteinDNArepairproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK11-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinqualitycontrolformisfoldedorincompletelysynthesizedproteins
Breakpoint cluster region protein
6.8
51
57
BCRBCRP11274P11274actincytoskeletonorganizationactivationofGTPaseactivitybraindevelopmentcellularresponsetolipopolysaccharidedefinitivehemopoiesisfocaladhesionassemblyhomeostasisofnumberofcellsinnerearmorphogenesisintracellularproteintransmembranetransportkeratinocytedifferentiationmacrophagemigrationmodulationofchemicalsynaptictransmissionnegativeregulationofbloodvesselremodelingnegativeregulationofcellularextravasationnegativeregulationofinflammatoryresponsenegativeregulationofmacrophagemigrationnegativeregulationofneutrophildegranulationnegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofrespiratoryburstneuromuscularprocesscontrollingbalanceneutrophildegranulationphagocytosispositiveregulationofphagocytosisproteinphosphorylationregulationofcellcycleregulationofnitrogencompoundmetabolicprocessregulationofRhoproteinsignaltransductionregulationofsmallGTPasemediatedsignaltransductionregulationofvascularpermeabilityrenalsystemprocesssignaltransductionsmallGTPasemediatedsignaltransduction
RNA-directed DNA polymerase
6.8
92
40
Q8TE30Q8TE30Q8TE30Q8TE30
Histone acetyltransferase type B catalytic subunit
6.8
61
57
✔
HAT1HAT1O14929O14929chromosomeorganizationhistoneH4acetylationinternalproteinaminoacidacetylationnucleosomeassemblysubtelomericheterochromatinformation
N-alpha-acetyltransferase 80
6.8
89
47
NAA80NAA80Q93015Q93015actinmodificationN-terminalpeptidyl-asparticacidacetylationN-terminalpeptidyl-glutamicacidacetylationproteinacetylationregulationofactinpolymerizationordepolymerization
WD repeat-containing protein 41
6.8
54
54
✔
WDR41WDR41Q9HAD4Q9HAD4autophagynegativeregulationofexocytosisnegativeregulationofimmuneresponsepositiveregulationofGTPaseactivityregulationofautophagy
Phosphoserine aminotransferase
6.9
89
40
SERCSERCQ9Y617Q9Y617L-serinebiosyntheticprocesspyridoxinebiosyntheticprocess
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
6.9
86
43
2AAA2AAAQ96DH3Q96DH3apoptoticprocessceramidemetabolicprocesschromosomesegregationfemalemeioticnucleardivisionmeioticsisterchromatidcohesioncentromericmeioticspindleelongationmitoticsisterchromatidseparationnegativeregulationofcellgrowthnegativeregulationofMAPKcascadenegativeregulationoftyrosinephosphorylationofSTATproteinpeptidyl-serinedephosphorylationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandproteindephosphorylationprotein-containingcomplexassemblyregulationofcelladhesionregulationofcelldifferentiationregulationofDNAreplicationregulationofDNA-templatedtranscriptionregulationofgrowthregulationofmeioticcellcycleprocessinvolvedinoocytematurationregulationofWntsignalingpathwayresponsetoorganicsubstanceRNAsplicingsecond-messenger-mediatedsignaling
Ras-related GTP-binding protein C
6.9
81
41
RRAGCRRAGCQ9HB90Q9HB90apoptoticprocesscellularresponsetoaminoacidstarvationcellularresponsetoaminoacidstimuluscellularresponsetostarvationDNA-templatedtranscriptionpositiveregulationofTORsignalingproteinlocalizationregulationofautophagyregulationofTORsignalingregulationofTORC1signalingresponsetoaminoacidRNAsplicingsmallGTPasemediatedsignaltransduction
Syncytin-1
2.1
36
86
SYCY1SYCY1Q9UQF0Q9UQF0anatomicalstructuremorphogenesismyoblastfusionsyncytiumformationsyncytiumformationbyplasmamembranefusion
CUGBP Elav-like family member 1
7.7
43
57
CELF1CELF1Q92879Q92879embryodevelopmentendinginbirthoregghatchinggermcelldevelopmentmRNAdestabilizationmRNAprocessingmRNAsplicesiteselectionnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionpositiveregulationofcelldeathpositiveregulationofgeneexpressionpost-transcriptionalgenesilencingregulationofalternativemRNAsplicingviaspliceosomeregulationofinflammatoryresponseregulationofRNAsplicingRNA-mediatedpost-transcriptionalgenesilencing
Tubulin alpha chain
6.9
84
42
A0A0R4I993A0A0R4I993A0A0R4I993A0A0R4I993microtubule-basedprocess
26S proteasome regulatory subunit 10B
6.9
60
51
✔
PRS10PRS10P62333P62333positiveregulationofinclusionbodyassemblypositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessubiquitin-dependentERADpathway
Transcription initiation factor TFIID subunit 1
2.1
49
84
✔
TAF1TAF1P21675P21675cellcyclecellularresponsetoATPcellularresponsetoDNAdamagestimuluscellularresponsetoUVmidbraindevelopmentmRNAtranscriptionbyRNApolymeraseIInegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofgeneexpressionnegativeregulationofproteinautoubiquitinationnegativeregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofubiquitin-dependentproteincatabolicprocesspeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofandrogenreceptoractivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinautophosphorylationproteinphosphorylationproteinpolyubiquitinationproteinstabilizationregulationofcellcycleG1/Sphasetransitionregulationofsignaltransductionbyp53classmediatorRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIItranscriptionfactorcatabolicprocesstranscriptioninitiationatRNApolymeraseIpromotertranscriptioninitiationatRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
AF4/FMR2 family member 4
6.9
102
40
AFF4AFF4Q9UHB7Q9UHB7regulationofgeneexpressionspermatiddevelopment
Ras-related protein Rab-7a
6.9
93
39
RAB7ARAB7AP09527P09527autophagosomeassemblyboneresorptionearlyendosometolateendosometransportendosometolysosometransportendosometoplasmamembraneproteintransportepidermalgrowthfactorcatabolicprocessestablishmentofvesiclelocalizationintracellulartransportlipidcatabolicprocesslipophagynegativeregulationofexosomalsecretionphagosomeacidificationphagosome-lysosomefusionpositiveregulationofexosomalsecretionpositiveregulationofproteincatabolicprocesspositiveregulationofviralprocessproteintargetingtolysosomeproteintomembranedockingresponsetobacteriumretrogradetransportendosometoGolgiviralreleasefromhostcell
DNA-directed RNA polymerase III subunit RPC6
6.9
60
57
RPC6RPC6Q9H1D9Q9H1D9defenseresponsetovirusinnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductionregulationoftranscriptionbyRNApolymeraseIIItranscriptionbyRNApolymeraseIII
Serine palmitoyltransferase 1
6.9
94
41
SPTC1SPTC1O15269O15269ceramidebiosyntheticprocesspositiveregulationoflipophagyregulationoffatcellapoptoticprocesssphinganinebiosyntheticprocesssphingolipidbiosyntheticprocesssphingolipidmetabolicprocesssphingomyelinbiosyntheticprocesssphingosinebiosyntheticprocess
Tyrosine-protein kinase RYK
6.9
68
52
RYKRYKP34925P34925axonextensioninvolvedinaxonguidanceaxonguidanceaxonogenesiscanonicalWntsignalingpathwaycellproliferationinmidbrainchemorepulsionofdopaminergicneuronaxoncommissuralneuronaxonguidancecorpuscallosumdevelopmentmidbraindopaminergicneurondifferentiationnegativeregulationofaxonextensioninvolvedinaxonguidanceneurogenesisneurondifferentiationneuronprojectiondevelopmentnon-canonicalWntsignalingpathwayphosphorylationplanarcellpolaritypathwayinvolvedinaxonguidancepositiveregulationofkinaseactivitypositiveregulationofMAPKcascadesignaltransductionskeletalsystemmorphogenesissynapseassemblytransmembranereceptorproteintyrosinekinasesignalingpathwayWntsignalingpathwayinvolvedinmidbraindopaminergicneurondifferentiation
Guanylate cyclase soluble subunit beta-1
3.7
76
69
GCYA1GCYB1Q02108Q02153bloodcirculationcGMPbiosyntheticprocesscGMP-mediatedsignalingnitricoxidemediatedsignaltransductionnitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofnitricoxidemediatedsignaltransductionregulationofbloodpressurerelaxationofvascularassociatedsmoothmuscleresponsetooxygenlevelsretrogradetrans-synapticsignalingbynitricoxidemodulatingsynaptictransmissioncellularresponsetonitricoxidetrans-synapticsignalingbynitricoxidemodulatingsynaptictransmission
Transient receptor potential cation channel subfamily V member 6
6.9
59
55
TRPV6TRPV6Q9H1D0Q9H1D0calciumionhomeostasiscalciumionimportacrossplasmamembranecalciumiontransmembranetransportcalciumiontransportparathyroidhormonesecretionregulationofcalciumion-dependentexocytosisresponsetocalciumion
Unconventional myosin-VI
6.9
85
50
MYO6MYO6Q29122Q29122actinfilamentorganizationactinfilament-basedmovementDNAdamageresponsesignaltransductionbyp53classmediatorendocytosisinnerearauditoryreceptorcelldifferentiationinnerearmorphogenesisintracellularproteintransportpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofsecretionsensoryperceptionofsoundvesicletransportalongactinfilament
Carbonyl reductase [NADPH] 1
6.9
88
40
✔
CBR1CBR1P16152P16152cyclooxygenasepathwayepithelialcelldifferentiationglucocorticoidmetabolicprocesspositiveregulationofreactiveoxygenspeciesmetabolicprocessvitaminKmetabolicprocessxenobioticmetabolicprocess
Aldo-keto reductase family 1 member B1
6.9
74
46
✔
ALDRALDRQ5U031Q5U031C21-steroidhormonebiosyntheticprocesscarbohydratemetabolicprocesscellularhyperosmoticsalinityresponsedaunorubicinmetabolicprocessdoxorubicinmetabolicprocessepithelialcellmaturationfructosebiosyntheticprocessmetanephriccollectingductdevelopmentnegativeregulationofapoptoticprocessregulationofurinevolumerenalwaterhomeostasisretinoidmetabolicprocess
YWHAE/FAM22B fusion protein
6.9
57
54
G9K389G9K389G9K389G9K389
Glucosylceramidase
2.2
70
84
B2R6A7B2R6A7B2R6A7B2R6A7cholesterolmetabolicprocesssphingolipidmetabolicprocess
Cytochrome P450 2E1
6.9
93
38
CP2E1CP2E1P05181P051814-nitrophenolmetabolicprocessbenzenemetabolicprocesscarbontetrachloridemetabolicprocessepoxygenaseP450pathwayhalogenatedhydrocarbonmetabolicprocessheterocyclemetabolicprocesslipidhydroxylationlong-chainfattyacidbiosyntheticprocesslong-chainfattyacidmetabolicprocessmonoterpenoidmetabolicprocessorganicacidmetabolicprocessresponsetobacteriumresponsetoethanolresponsetoorganonitrogencompoundresponsetoozonesteroidmetabolicprocesstriglyceridemetabolicprocessxenobioticmetabolicprocess
ADP-ribose glycohydrolase MACROD1
7.8
69
48
MACD1MACD1Q9BQ69Q9BQ69cellularresponsetoDNAdamagestimuluspeptidyl-glutamateADP-deribosylationproteinde-ADP-ribosylationpurinenucleosidemetabolicprocess
Ras-related protein Rab-9A
6.9
91
40
RAB9ARAB9AP51151P51151negativeregulationbyhostofsymbiontcatalyticactivitypositiveregulationofexocytosisproteintransportRabproteinsignaltransductionregulationofproteinlocalizationretrogradetransportendosometoGolgi
Protein transport protein Sec61 subunit alpha isoform 1
6.9
74
50
S61A1S61A1P38377P38377cotranslationalproteintargetingtomembranepost-translationalproteintargetingtomembranetranslocationpronephricnephrondevelopmentproteininsertionintoERmembraneproteintargetingtoERSRP-dependentcotranslationalproteintargetingtomembranetranslocation
26S proteasome non-ATPase regulatory subunit 4
6.9
81
47
PSMD4PSMD4P55036P55036proteasome-mediatedubiquitin-dependentproteincatabolicprocess
Protein PAXX
3.8
61
84
PAXXPAXXQ9BUH6Q9BUH6cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairvianonhomologousendjoining
Small nuclear ribonucleoprotein-associated protein
6.9
76
47
Q66K91Q66K91Q66K91Q66K91braindevelopment
40S ribosomal protein S14
6.9
58
51
RS14RS14P62263P62263cytoplasmictranslationerythrocytedifferentiationmaturationofSSU-rRNAmaturationofSSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)negativeregulationoftranscriptionbyRNApolymeraseIIribosomalsmallsubunitassemblytranslation
Aspartate--tRNA ligase, mitochondrial
6.9
83
43
SYDMSYDMQ6PI48Q6PI48aspartyl-tRNAaminoacylationmitochondrialasparaginyl-tRNAaminoacylationtRNAaminoacylation
Tubulin alpha chain
6.9
80
46
B6A7R0B6A7R0B6A7R0B6A7R0microtubule-basedprocess
Gamma-tubulin complex component 3
6.9
66
55
GCP3GCP3Q96CW5Q96CW5cytoplasmicmicrotubuleorganizationmeioticcellcyclemicrotubulenucleationmitoticcellcyclesinglefertilizationspindleassembly
AT-rich interactive domain-containing protein 4A
6.9
63
47
ARI4AARI4AP29374P29374erythrocytedevelopmentestablishmentofSertolicellbarrierhistoneH3-K4trimethylationhistoneH3-K9trimethylationhistoneH4-K20trimethylationnegativeregulationofcellmigrationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionbygenomicimprintingregulationoftranscriptionbyRNApolymeraseIIspermatogenesistranscriptionbyRNApolymeraseII
Cyclin-C
6.9
81
42
CCNCCCNCP24863P24863G0toG1transitionnegativeregulationofNotchsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
6.9
66
58
PDE3BPDE3BQ13370Q13370angiogenesiscellularresponsetoinsulinstimulusGprotein-coupledreceptorsignalingpathwaynegativeregulationofangiogenesisnegativeregulationofcAMP-mediatedsignalingnegativeregulationofcelladhesionnegativeregulationofcelladhesionmediatedbyintegrinnegativeregulationoflipidcatabolicprocesssignaltransduction
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1
6.0
68
55
PLCD1PLCD1P10688P10688angiogenesisGprotein-coupledreceptorsignalingpathwaylabyrinthinelayerbloodvesseldevelopmentlipidcatabolicprocessphosphatidylinositolmetabolicprocessphosphatidylinositol-mediatedsignalingpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofinositoltrisphosphatebiosyntheticprocesspositiveregulationofnorepinephrinesecretionregulationofcellpopulationproliferationregulationofcytosoliccalciumionconcentrationregulationofphospholipaseCactivityresponsetoaluminumionresponsetocalciumionresponsetohyperoxiaresponsetoorganonitrogencompoundresponsetopeptidehormoneresponsetoprostaglandinF
Peripheral plasma membrane protein CASK
6.9
53
57
CSKPCSKPO14936O14936calciumionimportcelladhesionestablishmentoflocalizationincellnegativeregulationofcell-matrixadhesionnegativeregulationofcellularresponsetogrowthfactorstimulusnegativeregulationofkeratinocyteproliferationnegativeregulationofwoundhealingpositiveregulationofcalciumionimportpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofneurotransmittersecretionregulationofsynapticvesicleexocytosis
Proteasome subunit beta type-6
6.9
101
41
PSB6PSB6P28072P28072proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocess
Serine/threonine-protein kinase pim-1
6.9
67
55
PIM1PIM1P11309P11309apoptoticprocesscellcyclecellulardetoxificationnegativeregulationofapoptoticprocessnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofbrownfatcelldifferentiationpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardioblastproliferationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinserine/threoninekinaseactivityproteinautophosphorylationproteinphosphorylationproteinstabilizationregulationofhematopoieticstemcellproliferationregulationoftransmembranetransporteractivityvitaminDreceptorsignalingpathway
Lactoylglutathione lyase
6.9
55
56
LGULLGULQ04760Q04760carbohydratemetabolicprocessglutathionemetabolicprocessmethylglyoxalmetabolicprocessnegativeregulationofapoptoticprocessosteoclastdifferentiationregulationoftranscriptionbyRNApolymeraseII
14-3-3 protein epsilon
6.9
56
54
1433E1433EP62258P62258cellularresponsetoheatcerebralcortexdevelopmenthippocampusdevelopmentintracellularsignaltransductionMAPKcascademembranerepolarizationduringcardiacmusclecellactionpotentialnegativeregulationofcalciumionexportacrossplasmamembranenegativeregulationofcalciumiontransmembranetransporteractivitynegativeregulationofpeptidyl-serinedephosphorylationneuronmigrationpositiveregulationofproteinexportfromnucleusproteinlocalizationtonucleusproteintargetingregulationofcytosoliccalciumionconcentrationregulationofheartratebycardiacconductionregulationofheartratebyhormoneregulationofmembranerepolarizationregulationofmitoticcellcycleregulationofpotassiumiontransmembranetransporteractivitysignaltransductionsubstantianigradevelopment
AP-1 complex subunit sigma-1A
6.9
84
40
AP1S1AP1S1P61967P61967basolateralproteinsecretionintracellularproteintransportmelanosomeassemblyplateletdensegranuleorganizationretrogradetransportendosometoGolgivesicle-mediatedtransport
Retinol-binding protein 2
6.9
62
54
RET2RET2P06768P06768fattyacidtransportretinolmetabolicprocess
Asparagine--tRNA ligase, cytoplasmic
7.8
53
56
SYNCSYNCO43776O43776asparaginyl-tRNAaminoacylationcellmigrationcerebralcortexdevelopmenttRNAaminoacylationforproteintranslation
Threonine--tRNA ligase 1, cytoplasmic
6.9
84
52
SYTCSYTCP26639P26639threonyl-tRNAaminoacylation
Tyrosine-protein phosphatase non-receptor type 9
6.9
76
50
PTN9PTN9P43378P43378negativeregulationofneuronprojectiondevelopmentpeptidyl-tyrosinedephosphorylationpositiveregulationofproteinlocalizationtoplasmamembraneproteindephosphorylation
Homeodomain-interacting protein kinase 3
6.9
63
54
HIPK3HIPK3Q9H422Q9H422apoptoticprocessmRNAtranscriptionnegativeregulationofapoptoticprocessnegativeregulationofJUNkinaseactivitypeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationproteinphosphorylation
TELO2-interacting protein 1 homolog
6.9
45
59
TTI1TTI1O43156O43156chromatinremodelingpositiveregulationofDNAdamagecheckpointproteinstabilizationregulationofTORsignaling
Dual specificity protein kinase TTK
6.9
69
49
TTKTTKP33981P33981chromosomesegregationfemalemeiosischromosomesegregationmeioticspindleassemblycheckpointsignalingmitoticspindleassemblycheckpointsignalingmitoticspindleorganizationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofpathway-restrictedSMADproteinphosphorylationproteinautophosphorylationproteinlocalizationtokinetochoreproteinlocalizationtomeioticspindlemidzonespindleorganization
Lysosomal acid glucosylceramidase
2.1
71
84
GBA1GBA1P04062P04062antigenprocessingandpresentationautophagosomeorganizationautophagybeta-glucosidecatabolicprocessbrainmorphogenesiscellmaturationcellularresponsetostarvationcellularresponsetotumornecrosisfactorceramidebiosyntheticprocesscerebellarPurkinjecelllayerformationcholesterolmetabolicprocessdeterminationofadultlifespanglucosylceramidecatabolicprocesshematopoieticstemcellproliferationhomeostasisofnumberofcellslipidglycosylationlipidstoragelymphocytemigrationlysosomeorganizationmicrogliadifferentiationmicroglialcellproliferationmotorbehaviornegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-6productionnegativeregulationofMAPkinaseactivitynegativeregulationofneuronapoptoticprocessnegativeregulationofneurondeathnegativeregulationofprotein-containingcomplexassemblyneuromuscularprocessneuronapoptoticprocesspositiveregulationofautophagyofmitochondrioninresponsetomitochondrialdepolarizationpositiveregulationofneuronalactionpotentialpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteindephosphorylationpositiveregulationofproteinlipidationpositiveregulationofproteinmetabolicprocesspositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofproteolysisinvolvedinproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocesspyramidalneurondifferentiationregulationoflysosomalproteincatabolicprocessregulationofmacroautophagyregulationofproteinmetabolicprocessregulationofTORsignalingregulationofwaterlossviaskinrespiratoryelectrontransportchainresponsetodexamethasoneresponsetoestrogenresponsetopHresponsetotestosteroneresponsetothyroidhormoneskinmorphogenesissphingosinebiosyntheticprocessTcelldifferentiationinthymusterminationofsignaltransduction
Phosphoglycerate kinase 1
2.0
62
84
✔
PGK1PGK1P00558P00558canonicalglycolysiscellularresponsetohypoxiaepithelialcelldifferentiationgluconeogenesisglycolyticprocessnegativeregulationofangiogenesisphosphorylationplasminogenactivation
Histone deacetylase 2
6.9
72
45
HDAC2HDAC2Q92769Q92769behavioralresponsetoethanolcardiacmusclehypertrophycellularresponsetodopaminecellularresponsetoheatcellularresponsetohydrogenperoxidecellularresponsetoretinoicacidcellularresponsetotransforminggrowthfactorbetastimuluschromatinremodelingcircadianregulationofgeneexpressiondendritedevelopmentembryonicdigitmorphogenesisepidermalcelldifferentiationeyeliddevelopmentincamera-typeeyefungiformpapillaformationhairfollicleplacodeformationheterochromatinorganizationhistonedeacetylationhistoneH3deacetylationhistoneH4deacetylationnegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofdendriticspinedevelopmentnegativeregulationofDNAbindingnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofMHCclassIIbiosyntheticprocessnegativeregulationofneuronprojectiondevelopmentnegativeregulationofpeptidyl-lysineacetylationnegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayodontogenesisofdentin-containingtoothpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofinterleukin-1productionpositiveregulationofmalematingbehaviorpositiveregulationofoligodendrocytedifferentiationpositiveregulationofproteolysispositiveregulationofsignalingreceptoractivitypositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcellfatespecificationregulationofstemcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIresponsetoamphetamineresponsetocaffeineresponsetococaineresponsetohyperoxiaresponsetolipopolysaccharideresponsetonicotineresponsetoxenobioticstimulus
ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase transferase B, alpha 1-3-galactosyltransferase)
6.9
75
50
F0X360F0X360F0X360F0X360carbohydratemetabolicprocess
Pre-rRNA-processing protein TSR1 homolog
6.9
82
44
TSR1TSR1Q2NL82Q2NL82endonucleolyticcleavageoftricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)maturationofSSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)
Acyl-coenzyme A thioesterase 2, mitochondrial
6.9
63
51
ACOT2ACOT2P49753P49753acyl-CoAmetabolicprocessfattyacidmetabolicprocesslong-chainfattyacidmetabolicprocessverylong-chainfattyacidmetabolicprocess
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
6.9
69
51
PMYT1PMYT1Q99640Q99640G2/Mtransitionofmitoticcellcyclemeioticcellcyclemitoticcellcycleproteinphosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofmitoticnucleardivision
3-mercaptopyruvate sulfurtransferase
6.9
89
47
THTMTHTMP25325P25325cyanatecatabolicprocesshydrogensulfidebiosyntheticprocesskidneydevelopmentliverdevelopmentresponsetotoxicsubstancespinalcorddevelopmentsulfuraminoacidcatabolicprocesstranssulfuration
Squamous cell carcinoma antigen recognized by T-cells 3
6.9
64
56
SART3SART3Q15020Q15020cellmorphogenesishematopoieticstemcellproliferationhomeostasisofnumberofcellsmRNAsplicingviaspliceosomenucleosomeassemblypositiveregulationofhistonedeubiquitinationregulationofgeneexpressionspliceosomalsnRNPassemblyspliceosomaltri-snRNPcomplexassembly
GTP-binding protein REM 1
6.9
73
46
REM1REM1O75628O75628negativeregulationofhighvoltage-gatedcalciumchannelactivity
Arylamine N-acetyltransferase 2
6.9
88
50
ARY2ARY2P11245P11245xenobioticmetabolicprocess
GTP-binding protein RAD
6.9
71
46
RADRADP55042P55042negativeregulationofhighvoltage-gatedcalciumchannelactivitysmallGTPasemediatedsignaltransduction
LINE-1 retrotransposable element ORF2 protein
6.9
93
40
LORF2LORF2O00370O00370DNArecombinationnucleicacidphosphodiesterbondhydrolysisreversetranscriptioninvolvedinRNA-mediatedtranspositiontranspositionRNA-mediated
Intermediate conductance calcium-activated potassium channel protein 4
6.9
59
51
KCNN4KCNN4O15554O15554calciumiontransportcellvolumehomeostasisdefenseresponseestablishmentoflocalizationincellimmunesystemprocessiontransportphospholipidtranslocationpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofproteinsecretionpositiveregulationofTcellreceptorsignalingpathwaypotassiumiontransmembranetransportpotassiumiontransportsalivasecretionstabilizationofmembranepotential
Neuronal-specific septin-3
6.9
84
41
SEPT3SEPT3Q9UH03Q9UH03cytoskeleton-dependentcytokinesis
Protein SEC13 homolog
7.8
83
40
✔
SEC13SEC13P55735P55735COPII-coatedvesiclebuddingCOPII-coatedvesiclecargoloadingintracellularproteintransportmRNAtransportnegativeregulationofTORC1signalingnucleocytoplasmictransportpositiveregulationofTORsignalingpositiveregulationofTORC1signalingproteinexitfromendoplasmicreticulumproteinimportintonucleus
Phosphoglucomutase-1
6.9
62
53
PGM1PGM1P00949P00949glucosemetabolicprocess
N6-adenosine-methyltransferase catalytic subunit
6.9
59
52
MTA70MTA70Q86U44Q86U44adenosinetoinosineeditingcellularresponsetoDNAdamagestimuluscellularresponsetoUVcircadianrhythmdosagecompensationbyinactivationofXchromosomeendothelialtohematopoietictransitionforebrainradialglialcelldifferentiationgliogenesisinnateimmuneresponsemRNAcatabolicprocessmRNAdestabilizationmRNAmethylationmRNAprocessingmRNAsplicingviaspliceosomenegativeregulationofNotchsignalingpathwaynegativeregulationoftypeIinterferon-mediatedsignalingpathwayoogenesispositiveregulationofcap-independenttranslationalinitiationpositiveregulationoftranslationprimarymiRNAprocessingregulationofhematopoieticstemcelldifferentiationregulationofmeioticcellcycleregulationofTcelldifferentiationRNAmethylationspermatogenesisstemcellpopulationmaintenance
Kinesin-like protein KIF21A
6.8
nan
62
KI21AKI21AQ7Z4S6Q7Z4S6microtubule-basedmovement
Protein cornichon homolog 3
8.0
42
56
CNIH3CNIH3Q6ZWS4Q6ZWS4localizationwithinmembraneneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofAMPAreceptoractivityregulationofmembranepotentialsynaptictransmissionglutamatergicvesicle-mediatedtransport
Heat shock protein HSP 90-alpha
6.9
88
42
HS90AHS90AP07900P07900activationofinnateimmuneresponseaxonextensioncardiacmusclecellapoptoticprocesscellularresponsetoheatcellularresponsetoviruscentralnervoussystemneuronaxonogenesischaperone-mediatedautophagychaperone-mediatedproteincomplexassemblyestablishmentofcellpolaritymitochondrialtransportneuronmigrationpositiveregulationofcardiacmusclecontractionpositiveregulationofcellsizepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofinterferon-betaproductionpositiveregulationoflamellipodiumassemblypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteincatabolicprocesspositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofproteinpolymerizationpositiveregulationoftau-proteinkinaseactivitypositiveregulationoftelomeraseactivityproteinfoldingproteininsertionintomitochondrialoutermembraneproteinrefoldingproteinstabilizationproteinunfoldingregulationofapoptoticprocessregulationofpostsynapticmembraneneurotransmitterreceptorlevelsregulationofproteinlocalizationregulationofproteinubiquitinationregulationofprotein-containingcomplexassemblyresponsetoantibioticresponsetococaineresponsetocoldresponsetoestrogenresponsetoheatresponsetosaltstressresponsetounfoldedproteinresponsetoxenobioticstimulusskeletalmusclecontractiontelomeraseholoenzymecomplexassemblytelomeremaintenanceviatelomerase
Septin-9
6.9
85
40
SEPT9SEPT9Q9UHD8Q9UHD8cytoskeleton-dependentcytokinesispositiveregulationofnon-motileciliumassembly
Potassium voltage-gated channel subfamily KQT member 2
6.9
56
57
KCNQ2KCNQ2O43526O43526chemicalsynaptictransmissionnervoussystemdevelopmentpotassiumiontransmembranetransportregulationofiontransmembranetransport
Septin-12
6.9
85
40
SEP12SEP12Q8IYM1Q8IYM1celldifferentiationcytoskeleton-dependentcytokinesisspermatogenesis
TRAF2 and NCK-interacting protein kinase
6.9
88
42
TNIKTNIKQ9UKE5Q9UKE5actincytoskeletonreorganizationcytoskeletonorganizationintracellularsignaltransductionMAPKcascademicrovillusassemblyneuronprojectionmorphogenesispositiveregulationofJNKcascadepositiveregulationofproteinphosphorylationproteinautophosphorylationproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofdendritemorphogenesisregulationofMAPKcascaderesponsetoorganonitrogencompoundWntsignalingpathway
Tripartite motif-containing protein 14
6.9
72
49
TRI14TRI14Q14142Q14142innateimmuneresponsenegativeregulationofviraltranscriptionpositiveregulationofautophagypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinpolyubiquitinationproteinubiquitinationregulationofgeneexpressionregulationofproteinlocalizationregulationofviralentryintohostcell
Adrenocortical dysplasia protein homolog
6.9
73
48
ACDACDQ96AP0Q96AP0embryoniclimbmorphogenesisestablishmentofproteinlocalizationtotelomereintracellularproteintransportnegativeregulationoftelomeremaintenanceviatelomerasepositiveregulationofsingle-strandedtelomericDNAbindingpositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenancepositiveregulationoftelomeremaintenanceviatelomeraseprotectionfromnon-homologousendjoiningattelomereproteinlocalizationtochromosometelomericregionsegmentationskeletalsystemdevelopmenttelomereassemblytelomerecappingtelomeremaintenancetelomeremaintenanceviatelomeraseurogenitalsystemdevelopment
Small nuclear ribonucleoprotein-associated proteins B and B'
6.9
80
45
RSMBRSMBP14678P146787-methylguanosinecaphypermethylationbraindevelopmentmRNAsplicingviaspliceosomeproteinmethylationRNAsplicingspliceosomalsnRNPassemblyU2-typeprespliceosomeassembly
Dihydropyrimidinase-related protein 2
6.9
90
45
DPYL2DPYL2O08553O08553celldifferentiationcytoskeletonorganizationendocytosisnervoussystemdevelopmentpositiveregulationofglutamatesecretionregulationofneurondifferentiationregulationofneuronprojectiondevelopmentsynapticvesicletransport
Small nuclear ribonucleoprotein Sm D2
7.0
75
49
SMD2RUXFP62317P62321mRNAsplicingviaspliceosomespliceosomalsnRNPassembly
Proliferation marker protein Ki-67
7.0
76
41
KI67KI67P46013P46013cellcyclecellpopulationproliferationregulationofchromatinorganizationregulationofchromosomesegregationregulationofmitoticnucleardivision
Synaptonemal complex protein 2
7.0
69
48
SYCP2SYCP2Q9CUU3Q9CUU3animalorganmorphogenesisapoptoticprocesscelldivisionectopicgermcellprogrammedcelldeathfemalemeioticnucleardivisionfertilizationmalegenitaliamorphogenesismalemeioticnucleardivisionmeioticnucleardivisionnegativeregulationofapoptoticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofreproductiveprocess
Pseudouridylate synthase 7 homolog
7.0
58
54
PUS7PUS7Q96PZ0Q96PZ0mRNAprocessingmRNApseudouridinesynthesisnegativeregulationoftranslationpseudouridinesynthesisregulationofhematopoieticstemcelldifferentiationregulationofmesodermdevelopmentRNAsplicingtRNApseudouridinesynthesis
MMS19 nucleotide excision repair protein homolog
4.0
90
65
✔
MMS19MMS19Q9D071Q9D071cellularresponsetoDNAdamagestimuluschromosomesegregationDNAmetabolicprocessDNArepairiron-sulfurclusterassemblypositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationproteinmaturationbyiron-sulfurclustertransfer
Myotonin-protein kinase
7.0
70
50
DMPKDMPKQ6P5Z6Q6P5Z6cellularcalciumionhomeostasisintracellularsignaltransductionmusclecellapoptoticprocessnuclearenvelopeorganizationpeptidyl-serinephosphorylationproteinphosphorylationregulationofexcitatorypostsynapticmembranepotentialinvolvedinskeletalmusclecontractionregulationofheartcontractionregulationofmyotubedifferentiationregulationofskeletalmusclecontractionbycalciumionsignalingregulationofsodiumiontransportregulationofsynapsestructuralplasticity
HAUS augmin-like complex subunit 5
7.0
67
50
✔
HAUS5HAUS5O94927O94927celldivisioncentrosomecyclespindleassembly
Succinate-semialdehyde dehydrogenase, mitochondrial
7.0
85
46
SSDHSSDHP51649P51649centralnervoussystemdevelopmentgamma-aminobutyricacidcatabolicprocessglutamatemetabolicprocessneurotransmittercatabolicprocessnitrogencompoundmetabolicprocesspost-embryonicdevelopmentsuccinatemetabolicprocess
Rho GTPase-activating protein 5
3.8
90
64
RHG05RHG05Q13017Q13017celladhesionmammaryglanddevelopmentregulationofcellsizeregulationofsmallGTPasemediatedsignaltransductionRhoproteinsignaltransduction
Proteasome subunit beta type-8
7.0
71
47
✔
PSB8PSB8P28062P28062antigenprocessingandpresentationfatcelldifferentiationproteasomalproteincatabolicprocessregulationofendopeptidaseactivity
NLR family CARD domain-containing protein 4
7.0
46
57
NLRC4NLRC4Q9NPP4Q9NPP4activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofinnateimmuneresponseapoptoticprocessdefenseresponsetobacteriumdetectionofbacteriumicosanoidbiosyntheticprocessinflammatoryresponseinnateimmuneresponsepatternrecognitionreceptorsignalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinprocessingproteinhomooligomerizationpyroptosis
Potassium voltage-gated channel subfamily B member 1
2.5
nan
94
KCNB1KCNB1Q14721Q14721actionpotentialcellularresponsetocalciumioncellularresponsetoglucosestimuluscellularresponsetonutrientlevelsclusteringofvoltage-gatedpotassiumchannelsglucosehomeostasisglutamatereceptorsignalingpathwaynegativeregulationofinsulinsecretionpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationoflong-termsynapticdepressionpositiveregulationofnorepinephrinesecretionpositiveregulationofproteintargetingtomembranepotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportproteinhomooligomerizationproteinlocalizationtoplasmamembraneregulationofactionpotentialregulationofiontransmembranetransportregulationofmotorneuronapoptoticprocessresponsetoaxoninjuryresponsetoL-glutamatevesicledockinginvolvedinexocytosis
Ras-related C3 botulinum toxin substrate 2
7.0
89
40
RAC2RAC2P15153P15153actinfilamentorganizationcellprojectionassemblycorticalcytoskeletonorganizationengulfmentofapoptoticcellestablishmentormaintenanceofcellpolarityGprotein-coupledreceptorsignalingpathwaylymphocyteaggregationmastcellproliferationmotorneuronaxonguidancepositiveregulationoflamellipodiumassemblypositiveregulationofmastcellproliferationpositiveregulationofneutrophilchemotaxispositiveregulationofproteintargetingtomitochondrionRacproteinsignaltransductionregulationofactincytoskeletonorganizationregulationofcellshaperegulationofcell-substrateadhesionregulationofhydrogenperoxidemetabolicprocessregulationofmastcellchemotaxisregulationofmastcelldegranulationregulationofneutrophilmigrationregulationofrespiratoryburstregulationofTcellproliferationrespiratoryburstsignaltransduction
Nucleotidyltransferase MB21D2
4.3
nan
80
M21D2M21D2Q8IYB1Q8IYB1
Ribosome biogenesis protein WDR12
7.0
82
48
WDR12WDR12Q9GZL7Q9GZL7maturationof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)maturationofLSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)Notchsignalingpathwayregulationofcellcycleribosomallargesubunitbiogenesis
C-C chemokine receptor type 9
2.0
nan
89
CCR9CCR9P51686P51686calcium-mediatedsignalingCD8-positivegamma-deltaintraepithelialTcelldifferentiationcellchemotaxiscellulardefenseresponsechemotaxisGprotein-coupledreceptorsignalingpathwayimmuneresponsepositiveregulationofcytosoliccalciumionconcentration
ATP-dependent 6-phosphofructokinase, liver type
7.6
82
42
PFKALPFKALP17858P17858canonicalglycolysisfructose16-bisphosphatemetabolicprocessfructose6-phosphatemetabolicprocessglycolyticprocessnegativeregulationofinsulinsecretionresponsetoglucose
Transcription regulator protein BACH2
2.0
53
86
BACH2BACH2Q9BYV9Q9BYV9importintonucleusnegativeregulationoftranscriptionbyRNApolymeraseIIprimaryadaptiveimmuneresponseinvolvingTcellsandBcellsregulationoftranscriptionbyRNApolymeraseII
GEM-interacting protein
7.0
39
59
GMIPGMIPQ9P107Q9P107activationofGTPaseactivityintracellularsignaltransductionnegativeregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransduction
Calcium/calmodulin-dependent protein kinase type II subunit alpha
7.0
97
39
KCC2AKCC2AQ9UQM7Q9UQM7angiotensin-activatedsignalingpathwaycalciumiontransportcellularresponsetointerferon-betadendriticspinedevelopmentG1/Stransitionofmitoticcellcyclenegativeregulationofhydrolaseactivitypeptidyl-serinephosphorylationpeptidyl-threonineautophosphorylationpositiveregulationofcalciumiontransportpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofreceptorsignalingpathwayviaJAK-STATproteinautophosphorylationproteinphosphorylationregulationofendocannabinoidsignalingpathwayregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocessregulationofneuronmigrationregulationofneuronalsynapticplasticityregulationofneurotransmittersecretionresponsetoischemia
Protein Dr1
7.0
66
48
✔
NC2BNC2BQ01658Q01658chromatinremodelinghistoneH3acetylationhistoneH3-K14acetylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleregulationofcelldivisionregulationofDNA-templatedtranscriptionregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylationRNApolymeraseIIpreinitiationcomplexassembly
HAUS augmin-like complex subunit 3
8.4
50
48
HAUS3HAUS3Q68CZ6Q68CZ6celldivisioncentrosomecyclespindleassembly
Origin recognition complex subunit 5
7.0
55
55
ORC5ORC5O43913O43913DNAreplicationDNAreplicationinitiationregulationofDNAreplication
Protein kinase C eta type
7.0
62
51
KPCLKPCLP24723P24723celldifferentiationintracellularsignaltransductionnegativeregulationofglialcellapoptoticprocesspeptidyl-serinephosphorylationpositiveregulationofBcellreceptorsignalingpathwaypositiveregulationofglialcellproliferationpositiveregulationofkeratinocytedifferentiationpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinlocalizationtoplasmamembraneproteinkinaseCsignalingproteinphosphorylationregulationofbicellulartightjunctionassemblysignaltransduction
Germ cell-specific gene 1-like protein
2.0
46
86
GSG1LGSG1LD3Z7H4D3Z7H4regulationofAMPAreceptoractivityregulationofpostsynapticneurotransmitterreceptorinternalization
Cytoplasmic polyadenylation element-binding protein 4
7.0
49
58
CPEB4CPEB4Q17RY0Q17RY0cellularresponsetoaminoacidstimuluscellularresponsetodecreasedoxygenlevelscellularresponsetoglucosestarvationionotropicglutamatereceptorsignalingpathwaynegativeregulationofcytoplasmictranslationnegativeregulationofneuronapoptoticprocessresponsetoischemia
WD repeat-containing protein 5
8.6
nan
41
WDR5Q76SB0P61964Q76SB0gluconeogenesishistoneH3acetylationhistoneH3-K14acetylationhistoneH3-K4methylationhistoneH4-K16acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationnegativeregulationofhistoneH3-K4methylationneuronprojectiondevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgluconeogenesispositiveregulationofhistoneH3-K4methylationregulationofcellcycleregulationofcelldivisionregulationofDNA-templatedtranscriptionregulationofdosagecompensationbyinactivationofXchromosomeregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylationskeletalsystemdevelopmenttranscriptioninitiation-coupledchromatinremodeling
Creatine kinase M-type
7.4
73
49
KCRMKCRMQ9XSC6Q9XSC6phosphocreatinebiosyntheticprocessphosphorylationresponsetoheat
Multidrug resistance-associated protein 1
6.6
65
53
MRP1MRP1Q8HXQ5Q8HXQ5exportacrossplasmamembraneglutathionetransmembranetransportleukotrienetransportphospholipidtranslocationpositiveregulationofinflammatoryresponseresponsetoxenobioticstimulussphingolipidtranslocationtransepithelialtransporttransmembranetransportxenobiotictransportxenobiotictransportacrossblood-brainbarrier
Syntaxin-1A
3.7
53
76
VAMP2STX1AP63045P32851calcium-ionregulatedexocytosiscellularresponsetoinsulinstimuluseosinophildegranulationestablishmentoflocalizationincellexocyticinsertionofneurotransmitterreceptortopostsynapticmembraneGolgitoplasmamembraneproteintransporthormonesecretionlong-termsynapticpotentiationmembranefusionpositiveregulationofintracellularproteintransportproteintransportprotein-containingcomplexassemblyregulatedexocytosisregulationofdelayedrectifierpotassiumchannelactivityregulationofexocytosisregulationofsynapticvesiclerecyclingregulationofvesicle-mediatedtransportresponsetoglucoseSNAREcomplexassemblysynapticvesicledockingsynapticvesicleendocytosissynapticvesicleexocytosisvesiclefusionvesicle-mediatedtransportexocytosisinsulinsecretionintracellularproteintransportmodulationofexcitatorypostsynapticpotentialneurotransmittertransportpositiveregulationofcalciumion-dependentexocytosispositiveregulationofcatecholaminesecretionpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofexocytosispositiveregulationofneurotransmittersecretionpositiveregulationofnorepinephrinesecretionproteinlocalizationtomembraneproteinsumoylationregulationofsynapticvesicleprimingresponsetogravitysecretionbycellsynapticvesiclefusiontopresynapticactivezonemembranevesicledocking
Protein arginine N-methyltransferase 2
7.1
80
46
Q3UKX1Q3UKX1Q3UKX1Q3UKX1peptidyl-argininemethylation
Ethanolamine-phosphate cytidylyltransferase
7.1
74
47
PCY2PCY2Q99447Q99447phosphatidylethanolaminebiosyntheticprocessphospholipidbiosyntheticprocess
Alkyldihydroxyacetonephosphate synthase, peroxisomal
3.6
81
71
ADASADASP97275P97275etherlipidbiosyntheticprocess
Glutamate receptor 1
2.0
47
88
GRIA1GRIA1P19490P19490cellularresponsetoaminestimuluscellularresponsetoaminoacidstimuluscellularresponsetoammoniumioncellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetodsRNAcellularresponsetogrowthfactorstimuluscellularresponsetoorganiccycliccompoundcellularresponsetopeptidehormonestimuluscerebralcortexdevelopmentchemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticiontransmembranetransportlong-termmemorylong-termsynapticdepressionmodulationofchemicalsynaptictransmissionneuronalactionpotentialpositiveregulationofgeneexpressionpositiveregulationofmembranepotentialpositiveregulationofsynaptictransmissionreceptorinternalizationregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingregulationofsynapticplasticityresponsetoarsenic-containingsubstanceresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetofungicideresponsetolithiumionresponsetoorganiccycliccompoundresponsetopeptidehormoneresponsetotoxicsubstanceresponsetoxenobioticstimulusspinalcorddevelopmentsynapseassemblysynaptictransmissionglutamatergic
Leucine-rich repeat and fibronectin type-III domain-containing protein 4
2.0
49
87
LRFN4LRFN4Q80XU8Q80XU8regulationofpostsynapticdensityassemblyregulationofpresynapseassemblysynapticmembraneadhesion
AMP deaminase 2
7.1
79
43
AMPD2AMPD2Q01433Q01433AMPmetabolicprocesscyclicpurinenucleotidemetabolicprocessenergyhomeostasisIMPbiosyntheticprocessIMPsalvage
Cyclic nucleotide-gated cation channel beta-3
7.1
63
48
CNGB3CNGB3Q9NQW8Q9NQW8cationtransmembranetransportcationtransportsignaltransductionvisualperception
Thiosulfate sulfurtransferase
7.1
95
47
THTRTHTRQ16762Q16762cyanatecatabolicprocessepithelialcelldifferentiationrRNAimportintomitochondrionrRNAtransportsulfuraminoacidcatabolicprocesstranssulfuration
Cytochrome P450 1A2
7.1
73
44
CP1A2CP1A2P05177P05177aflatoxinmetabolicprocessalkaloidmetabolicprocesscellularrespirationcellularresponsetocadmiumioncholesterolmetabolicprocessdibenzo-p-dioxinmetabolicprocessepoxygenaseP450pathwayestrogenmetabolicprocessheterocyclemetabolicprocesshydrogenperoxidebiosyntheticprocesslong-chainfattyacidbiosyntheticprocesslungdevelopmentmethylationmonocarboxylicacidmetabolicprocessmonoterpenoidmetabolicprocessomega-hydroxylaseP450pathwayoxidativedemethylationporphyrin-containingcompoundmetabolicprocesspost-embryonicdevelopmentregulationofgeneexpressionretinolmetabolicprocesssteroidcatabolicprocesstoxinbiosyntheticprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
Phenylalanine--tRNA ligase, mitochondrial
7.1
67
47
SYFMSYFMO95363O95363phenylalanyl-tRNAaminoacylationtRNAaminoacylationforproteintranslationtRNAprocessing
Bardet-Biedl syndrome 2 protein homolog
8.5
70
40
Q32L13Q32L13Q32L13Q32L13non-motileciliumassembly
Ras-related C3 botulinum toxin substrate 3
7.1
88
41
RAC3RAC3P60763P60763actincytoskeletonorganizationactinfilamentorganizationcellprojectionassemblycerebralcortexGABAergicinterneurondevelopmentcorticalcytoskeletonorganizationestablishmentormaintenanceofcellpolarityhomeostasisofnumberofcellswithinatissueintracellularsignaltransductionneuromuscularprocesscontrollingbalanceneuronprojectiondevelopmentpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofsubstrateadhesion-dependentcellspreadingpostsynapticactincytoskeletonorganizationregulationofactincytoskeletonorganizationregulationofcellshaperegulationofneuronmaturationrespiratoryburstsmallGTPasemediatedsignaltransductionsynaptictransmissionGABAergicWntsignalingpathway
Protein N-lysine methyltransferase METTL21D
7.1
78
50
MT21DMT21DQ9H867Q9H867negativeregulationofATP-dependentactivitypeptidyl-lysinemethylationpeptidyl-lysinetrimethylationproteinmethylation
Tyrosine-protein phosphatase non-receptor type 2
7.1
65
47
PTN2PTN2P17706P17706BcelldifferentiationerythrocytedifferentiationglucosehomeostasisinsulinreceptorrecyclinginsulinreceptorsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofchemotaxisnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofERK1andERK2cascadenegativeregulationofinflammatoryresponsenegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofinterleukin-2-mediatedsignalingpathwaynegativeregulationofinterleukin-4-mediatedsignalingpathwaynegativeregulationofinterleukin-6-mediatedsignalingpathwaynegativeregulationoflipidstoragenegativeregulationofmacrophagecolony-stimulatingfactorsignalingpathwaynegativeregulationofmacrophagedifferentiationnegativeregulationofplatelet-derivedgrowthfactorreceptor-betasignalingpathwaynegativeregulationofpositivethymicTcellselectionnegativeregulationofproteintyrosinekinaseactivitynegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofTcellreceptorsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaynegativeregulationoftypeIinterferon-mediatedsignalingpathwaynegativeregulationoftypeIIinterferon-mediatedsignalingpathwaynegativeregulationoftyrosinephosphorylationofSTATproteinpeptidyl-tyrosinedephosphorylationpositiveregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofgluconeogenesispositiveregulationofPERK-mediatedunfoldedproteinresponseregulationofhepatocytegrowthfactorreceptorsignalingpathwayregulationoftypeIIinterferon-mediatedsignalingpathwayTcelldifferentiation
Probable methyltransferase TARBP1
8.2
81
41
TARB1TARB1Q13395Q13395regulationoftranscriptionbyRNApolymeraseIItRNAmethylation
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
7.9
81
41
F261F261P16118P16118animalorganregenerationfructose26-bisphosphatemetabolicprocessfructosemetabolicprocessgluconeogenesisglycolyticprocesspositiveregulationofglucokinaseactivityresponsetocAMPresponsetoglucagonresponsetoglucocorticoidresponsetoinsulinresponsetostarvation
5-aminolevulinate synthase, erythroid-specific, mitochondrial
7.1
78
43
HEM0HEM0P22557P22557cellularironionhomeostasiscellularoxygenhomeostasiserythrocytedevelopmenterythrocytedifferentiationhemebiosyntheticprocesshemoglobinbiosyntheticprocessprotoporphyrinogenIXbiosyntheticprocessresponsetohypoxia
Periaxin
7.1
68
48
PRAXPRAXQ9BXM0Q9BXM0axonensheathmentperipheralnervoussystemmyelinmaintenanceregulationofRNAsplicing
Ras-related protein Rab-9B
7.1
91
49
RAB9BRAB9BQ9NP90Q9NP90proteintransportRabproteinsignaltransductionretrogradetransportendosometoGolgi
Retinoid isomerohydrolase
9.3
nan
49
RPE65RPE65Q28175Q28175responsetostimulusvisualperceptionzeaxanthinbiosyntheticprocess
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
7.1
57
57
F1SIS9F1SIS9F1SIS9F1SIS9mitochondrialelectrontransportNADHtoubiquinone
Anaphase-promoting complex subunit 10
7.1
63
55
APC10APC1Q9UM13Q9H1A4anaphase-promotingcomplex-dependentcatabolicprocesscellcyclecelldivisionproteinK11-linkedubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcyclemetaphase/anaphasetransitionofmitoticcellcycle
Transcription initiation factor TFIID subunit 2
7.1
54
57
TAF2TAF2Q6P1X5Q6P1X5G2/MtransitionofmitoticcellcyclehistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationmRNAtranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinphosphorylationregulationofDNArepairregulationoftranscriptionbyRNApolymeraseIIresponsetoorganiccycliccompoundRNApolymeraseIIpreinitiationcomplexassemblytranscriptioninitiationatRNApolymeraseIIpromoter
Dynein light chain 1, cytoplasmic
9.4
51
43
DYL1DYL1P63170P63170apoptoticprocessintraciliaryretrogradetransportmitocytosismotileciliumassemblynegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofphosphorylationneurotransmittermetabolicprocessnitricoxidebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofnon-motileciliumassemblyregulationofmitochondrialmembranepotentialspermatiddevelopment
T-complex protein 1 subunit beta
7.1
81
48
TCPBTCPBQ3ZBH0Q3ZBH0bindingofspermtozonapellucidachaperonemediatedproteinfoldingindependentofcofactorchaperone-mediatedproteincomplexassemblypositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationoftelomeraseactivitypositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationscaRNAlocalizationtoCajalbodytoxintransport
Protein 4.2
7.1
45
58
EPB42EPB42P16452P16452cellmorphogenesiserythrocytematurationhemoglobinmetabolicprocessironionhomeostasispeptidecross-linkingregulationofcellshapespleendevelopment
U5 small nuclear ribonucleoprotein 40 kDa protein
7.1
99
34
SNR40SNR40Q96DI7Q96DI7mRNAsplicingviaspliceosomeRNAprocessingRNAsplicingRNAsplicingviatransesterificationreactions
ATP-binding cassette sub-family C member 8 isoform X1
7.1
61
50
A0A1U8CME7A0A1U8CME7A0A1U8CME7A0A1U8CME7potassiumiontransport
NAD(P) transhydrogenase, mitochondrial
7.1
86
44
NNTMNNTMW5PFI3W5PFI3protontransmembranetransport
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
7.1
77
46
PDE1BPDE1BQ01064Q01064cellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetomacrophagecolony-stimulatingfactorstimuluslocomotorybehaviormonocytedifferentiationregulationofdopaminemetabolicprocessregulationofneurotransmitterlevelsresponsetoamphetamineserotoninmetabolicprocesssignaltransductionvisuallearning
Microprocessor complex subunit DGCR8
7.1
49
62
DGCR8DGCR8Q8WYQ5Q8WYQ5primarymiRNAprocessingregulationofstemcellproliferation
Bystin
7.1
67
49
✔
BYSTBYSTQ13895Q13895maturationofSSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)regulationofproteinlocalizationtonucleolusribosomebiogenesisrRNAprocessingstemcellproliferationtrophectodermalcelldifferentiation
GATOR complex protein NPRL2
4.8
60
66
NPRL2NPRL2Q8WTW4Q8WTW4cellularresponsetoaminoacidstarvationnegativeregulationofkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingpositiveregulationofautophagy
Gamma-tubulin complex component 5
7.1
69
52
GCP5GCP5Q96RT8Q96RT8cytoplasmicmicrotubuleorganizationmeioticcellcyclemicrotubulenucleationmitoticcellcyclespindleassembly
ATP-binding cassette sub-family C member 8 isoform X2
2.0
79
80
A0A1U7R319A0A1U7R319A0A1U7R319A0A1U7R319inorganiccationtransmembranetransportnegativeregulationofinsulinsecretionpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulus
Ribonuclease P/MRP protein subunit POP5
7.5
55
55
✔
POP5POP7Q969H6O75817rRNAprocessing"tRNA5-leaderremoval"tRNAprocessingRNAphosphodiesterbondhydrolysisendonucleolytic
Exosome complex component RRP41
7.2
96
34
EXOS4EXOS4Q9NPD3Q9NPD3defenseresponsetovirusDNAdeaminationhistonemRNAcatabolicprocessmaturationof5.8SrRNAnuclearmRNAsurveillancenuclear-transcribedmRNAcatabolicprocess"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5""polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationofcellgrowthRNAcatabolicprocessRNAprocessingrRNAcatabolicprocessrRNAprocessing"U4snRNA3-endprocessing"
Heat shock protein HSP 90-beta
8.8
40
44
HS90BHS90BP08238P08238axonextensioncellularresponsetoheatcellularresponsetointerleukin-4centralnervoussystemneuronaxonogenesischaperone-mediatedproteincomplexassemblyestablishmentofcellpolaritynegativeregulationofapoptoticprocessnegativeregulationofproteasomalproteincatabolicprocessnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinmetabolicprocessnegativeregulationoftransforminggrowthfactorbetaactivationplacentadevelopmentpositiveregulationofcelldifferentiationpositiveregulationofcyclin-dependentproteinkinaseactivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtocellsurfacepositiveregulationoftau-proteinkinaseactivitypositiveregulationoftelomeraseactivitypositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinfoldingproteinstabilizationregulationofcellcycleregulationofproteinlocalizationregulationofproteinubiquitinationresponsetounfoldedproteinsupramolecularfiberorganizationtelomeraseholoenzymecomplexassemblytelomeremaintenanceviatelomerasevirionattachmenttohostcell
Ubiquitin carboxyl-terminal hydrolase 19
7.2
60
55
UBP19UBP19O94966O94966negativeregulationofskeletalmuscletissuedevelopmentpositiveregulationofcellcycleprocessproteindeubiquitinationproteinstabilizationregulationofcellularresponsetohypoxiaregulationofERADpathwayregulationofproteinstabilityresponsetoendoplasmicreticulumstressubiquitin-dependentERADpathway
Melatonin receptor type 1A
2.0
72
82
MTR1AMTR1AP48039P48039adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaycircadianrhythmGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengermatingbehavior
DNA mismatch repair protein Mlh1
7.2
44
53
✔
MLH1MLH1P40692P40692double-strandbreakrepairvianonhomologousendjoiningfemalemeiosischromosomesegregationhomologouschromosomepairingatmeiosisintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageisotypeswitchingmalemeiosischromosomesegregationmeioticmetaphaseIplatecongressionmeioticspindlemidzoneassemblymeiotictelomereclusteringmismatchrepairnegativeregulationofmitoticrecombinationnuclear-transcribedmRNApoly(A)tailshorteningoogenesispositiveregulationofisotypeswitchingtoIgAisotypespositiveregulationofisotypeswitchingtoIgGisotypesresolutionofmeioticrecombinationintermediatesresponsetobacteriumsomatichypermutationofimmunoglobulingenesspermatogenesis
Protein cornichon homolog 2
7.2
45
57
CNIH2CNIH2O35089O35089localizationwithinmembranenegativeregulationofanterogradesynapticvesicletransportnegativeregulationofreceptorlocalizationtosynapseregulationofAMPAreceptoractivityregulationofmembranepotentialregulationofNMDAreceptoractivityregulationofpostsynapticneurotransmitterreceptoractivitysynaptictransmissionglutamatergicvesicle-mediatedtransport
Reduced folate transporter
7.2
55
54
S19A1S19A1P41440P41440cyclic-GMP-AMPtransmembraneimportacrossplasmamembranefemalepregnancyfolateimportacrossplasmamembranefolatetransmembranetransportfolicacidmetabolicprocessfolicacidtransportmethotrexatetransportorganicaniontransporttransmembranetransporttransportacrossblood-brainbarrierxenobiotictransmembranetransport
Protein mono-ADP-ribosyltransferase PARP9
7.2
73
45
PARP9PARP9Q8IXQ6Q8IXQ6cellmigrationdefenseresponsetovirusDNAdamagecheckpointsignalingdouble-strandbreakrepairinnateimmuneresponseNADbiosynthesisvianicotinamideribosidesalvagepathwaynegativeregulationofcatalyticactivitynegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofchromatinbindingpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinlocalizationtonucleuspositiveregulationoftypeIIinterferon-mediatedsignalingpathwaypositiveregulationoftyrosinephosphorylationofSTATproteinpost-transcriptionalregulationofgeneexpressionregulationofresponsetotypeIIinterferonviralproteinprocessing
Histone deacetylase 1
7.2
68
44
HDAC1HDAC1Q13547Q13547cellularresponsetoplatelet-derivedgrowthfactorstimuluschromatinorganizationchromatinremodelingcircadianregulationofgeneexpressionDNAmethylation-dependentheterochromatinformationembryonicdigitmorphogenesisendodermdevelopmentepidermalcelldifferentiationeyeliddevelopmentincamera-typeeyefungiformpapillaformationhairfollicleplacodeformationhippocampusdevelopmenthistonedeacetylationhistoneH3deacetylationhistoneH4deacetylationnegativeregulationbyhostofviraltranscriptionnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofintrinsicapoptoticsignalingpathwaynegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayneurondifferentiationodontogenesisofdentin-containingtootholigodendrocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofoligodendrocytedifferentiationpositiveregulationofsignalingreceptoractivitypositiveregulationofsmoothmusclecellproliferationpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIproteindeacetylationregulationofamyloid-betaclearanceregulationofcellfatespecificationregulationofendopeptidaseactivityregulationofstemcelldifferentiationregulationoftranscriptionbyRNApolymeraseII
39S ribosomal protein L43, mitochondrial
7.2
45
51
RM43RM43Q8N983Q8N983mitochondrialtranslationtranslation
RNA-binding protein 4B
7.2
59
59
RBM4BRBM4BQ9BQ04Q9BQ04circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodmRNAsplicingviaspliceosomepositiveregulationofgeneexpressionregulationoftranslation
Xaa-Pro aminopeptidase 1
7.2
62
53
XPP1XPP1Q9NQW7Q9NQW7bradykinincatabolicprocessproteolysis
GMP reductase 1
7.2
75
44
GMPR1GMPR1P36959P36959purinenucleobasemetabolicprocesspurinenucleotidemetabolicprocessresponsetocold
LIM domain-binding protein 1
3.8
56
85
LDB1LDB1P70662P70662anterior/posterioraxisspecificationcelladhesioncelldifferentiationcellularcomponentassemblycerebellarPurkinjecelldifferentiationcerebellumdevelopmentepithelialstructuremaintenancegastrulationwithmouthformingsecondhairfollicledevelopmentheaddevelopmenthistoneH3-K4acetylationmesendodermdevelopmentnegativeregulationofDNA-templatedtranscriptionnegativeregulationoferythrocytedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneurondifferentiationpositiveregulationofcelladhesionpositiveregulationofhemoglobinbiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIprimitiveerythrocytedifferentiationregulationofcellmigrationregulationoffocaladhesionassemblyregulationofkinaseactivityregulationoftranscriptionelongationbyRNApolymeraseIIsomaticstemcellpopulationmaintenancetranscriptionbyRNApolymeraseIItranscription-dependenttetheringofRNApolymeraseIIgeneDNAatnuclearperipheryWntsignalingpathway
ADP-ribosylation factor-like protein 8A
7.2
67
50
ARL8AARL8AQ96BM9Q96BM9anterogradeaxonaltransportcelldivisionchromosomesegregationproteintransport
SUMO-activating enzyme subunit 1
6.5
65
52
✔
SAE1SAE1Q9UBE0Q9UBE0positiveregulationofproteinsumoylationpositiveregulationofproteintargetingtomitochondrionproteinmodificationbysmallproteinconjugationproteinsumoylation
Growth factor receptor-bound protein 10
7.2
61
50
GRB10GRB10Q13322Q13322ERK1andERK2cascadegeneexpressioninsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofglucoseimportnegativeregulationofglycogenbiosyntheticprocessnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofphosphorylationnegativeregulationofWntsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofphosphorylationpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayresponsetoinsulinvascularassociatedsmoothmusclecellmigration
Inosine-5'-monophosphate dehydrogenase 1
7.2
91
37
✔
IMDH1IMDH1P20839-5P20839-5
Tubulin alpha chain
8.0
63
48
F2Z4C1F2Z4C1F2Z4C1F2Z4C1microtubulecytoskeletonorganizationmitoticcellcycle
DNA-directed RNA polymerase I subunit RPA43
7.2
57
55
RPA43RPA43Q3B726Q3B726cellularresponsetoleukemiainhibitoryfactorDNA-templatedtranscriptioninitiation
Thialysine N-epsilon-acetyltransferase
7.2
70
53
SAT2SAT2Q96F10Q96F10nor-spermidinemetabolicprocessputrescineacetylationspermidineacetylationspermineacetylation
Sphingosine kinase 1
8.7
62
43
SPHK1SPHK1Q9NYA1Q9NYA1bloodvesseldevelopmentbraindevelopmentcalcium-mediatedsignalingcellpopulationproliferationcellularresponsetogrowthfactorstimuluscellularresponsetohydrogenperoxidecellularresponsetovascularendothelialgrowthfactorstimulusDNAbiosyntheticprocessinflammatoryresponseintracellularsignaltransductionnegativeregulationofapoptoticprocessnegativeregulationofceramidebiosyntheticprocessphosphorylationpositiveregulationofangiogenesispositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationoffibroblastproliferationpositiveregulationofinterleukin-17productionpositiveregulationofmitoticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofp38MAPKcascadepositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofsmoothmusclecontractionproteinacetylationregulationofendocytosisregulationofendosomalvesiclefusionregulationofinterleukin-1betaproductionregulationofmicroglialcellactivationregulationofneuroinflammatoryresponseregulationofphagocytosisregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetotumornecrosisfactorsphingoidcatabolicprocesssphingolipidbiosyntheticprocesssphingolipidmetabolicprocesssphingosinebiosyntheticprocesssphingosinemetabolicprocess
Unconventional myosin-XV
3.5
64
78
MYO15MYO15Q9QZZ4Q9QZZ4actinfilamentorganizationinnerearmorphogenesislocomotorybehaviorresponsetolightstimulussensoryperceptionofsoundvesicletransportalongactinfilament
Tripartite motif-containing protein 3
7.2
75
50
TRIM3TRIM3O75382O75382nervoussystemdevelopmentproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteintransport
Solute carrier family 26 member 9
7.2
58
50
A0A0R4J0F7A0A0R4J0F7A0A0R4J0F7A0A0R4J0F7positiveregulationofgeneexpression
39S ribosomal protein L37, mitochondrial
7.2
57
48
RM37RM37Q9BZE1Q9BZE1mitochondrialtranslationtranslation
26S proteasome regulatory subunit 6A
7.2
88
44
✔
PRS6APRS6AP17980P17980modulationbyhostofviraltranscriptionpositiveregulationofproteasomalproteincatabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocess
Chloride channel protein 1
7.8
25
59
CLCN1CLCN1P35523P35523chloridetransmembranetransportchloridetransportmusclecontractionneuronalactionpotentialpropagationregulationofiontransmembranetransport
Retinoic acid receptor gamma
7.2
76
42
RARGRARGP13631P13631anterior/posteriorpatternspecificationapoptoticprocesscanonicalWntsignalingpathwaycelldifferentiationcellularresponsetoleukemiainhibitoryfactorcellularresponsetoretinoicacidembryoniccamera-typeeyedevelopmentembryoniceyemorphogenesisembryonichindlimbmorphogenesisfacedevelopmentglandularepithelialcelldevelopmentgrowthplatecartilagechondrocytegrowthHarderianglanddevelopmenthormone-mediatedsignalingpathwaymulticellularorganismgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofchondrocytedifferentiationnegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIneuraltubeclosurepositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationpositiveregulationofgeneexpressionpositiveregulationofprogrammedcelldeathpositiveregulationoftranscriptionbyRNApolymeraseIIprostateglandepitheliummorphogenesisregulationofcellsizeregulationofmyelinationregulationofmyeloidcelldifferentiationresponsetoretinoicacidretinoicacidreceptorsignalingpathwaystemcellproliferationtracheacartilagedevelopment
Putative tyrosine-protein phosphatase auxilin
7.2
70
41
AUXIAUXIQ27974Q27974clathrincoatdisassemblyclathrin-dependentendocytosisdephosphorylationsynapticvesicleuncoating
ADP-ribosylation factor-like protein 8B
7.2
63
49
✔
ARL8BARL8BQ9NVJ2Q9NVJ2anterogradeaxonaltransportantigenprocessingandpresentationfollowingphagocytosisantigenprocessingandpresentationofpolysaccharideantigenviaMHCclassIIautophagosome-lysosomefusioncalciumionregulatedlysosomeexocytosiscelldivisionchromosomesegregationendosomaltransportendosometolysosometransportoflow-densitylipoproteinparticlelateendosometolysosometransportlysosomelocalizationnaturalkillercellmediatedcytotoxicityphagosome-lysosomefusionplasmamembranerepairproteintransportviralexocytosis
Transient receptor potential cation channel, subfamily M, member 3
6.2
nan
71
Q5F4S7Q5F4S7Q5F4S7Q5F4S7cationtransmembranetransportcationtransportproteintetramerization
Hydroxyacylglutathione hydrolase, mitochondrial
7.2
76
43
GLO2GLO2Q16775Q16775glutathionebiosyntheticprocessglutathionemetabolicprocessmethylglyoxalcatabolicprocesstoD-lactateviaS-lactoyl-glutathione
Peroxisomal coenzyme A diphosphatase NUDT7
7.2
69
46
NUDT7NUDT7P0C024P0C024acetyl-CoAcatabolicprocessbrownfatcelldifferentiationbutyryl-CoAcatabolicprocesscoenzymeAcatabolicprocessmalonyl-CoAcatabolicprocessmedium-chainfatty-acyl-CoAcatabolicprocessnucleosidediphosphatemetabolicprocesspropionyl-CoAcatabolicprocesspropionyl-CoAmetabolicprocesssuccinyl-CoAcatabolicprocess
Carbamoyl-phosphate synthase [ammonia], mitochondrial
7.2
79
44
CPSMCPSMP31327P31327"denovopyrimidinenucleobasebiosyntheticprocess"anionhomeostasiscarbamoylphosphatebiosyntheticprocesscellularresponsetoammoniumioncellularresponsetocAMPcellularresponsetofibroblastgrowthfactorstimuluscellularresponsetoglucagonstimuluscellularresponsetooleicacidcitrullinebiosyntheticprocessglutaminemetabolicprocesshepatocytedifferentiationhomocysteinemetabolicprocessmidgutdevelopmentnitricoxidemetabolicprocessnitrogencompoundmetabolicprocessresponsetoamineresponsetoaminoacidresponsetodexamethasoneresponsetofoodresponsetogrowthhormoneresponsetolipopolysaccharideresponsetostarvationresponsetotoxicsubstanceresponsetoxenobioticstimulusresponsetozincionsequesteringofmetaliontriglyceridecatabolicprocessureacyclevasodilation
40S ribosomal protein S8
8.2
38
44
RS8RS8P62241P62241cytoplasmictranslationmaturationofSSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)translation
Farnesyl pyrophosphate synthase
7.2
77
50
FPPSFPPSP14324P14324cholesterolbiosyntheticprocessfarnesyldiphosphatebiosyntheticprocessgeranyldiphosphatebiosyntheticprocess
Calcium-regulated heat-stable protein 1
7.2
63
54
CHSP1CHSP1Q9Y2V2Q9Y2V2intracellularsignaltransductionregulationofmRNAstability
T-complex protein 1 subunit alpha
7.2
69
49
TCPATCPAP17987P17987bindingofspermtozonapellucidachaperone-mediatedproteinfoldingpositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationoftelomeraseactivitypositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationregulationofmacrophageapoptoticprocessscaRNAlocalizationtoCajalbodytoxintransporttranslocationofpeptidesorproteinsintohostcellcytoplasmtubulincomplexassembly
Macrophage migration inhibitory factor
7.2
74
48
A0A140EDM8A0A140EDM8A0A140EDM8A0A140EDM8
Putative methyltransferase C9orf114
7.3
86
49
CI114CI114Q5T280Q5T280cellcyclecelldivisionmaintenanceofcentrosomelocationmethylationmiRNAprocessingpost-transcriptionalregulationofgeneexpression
40S ribosomal protein SA
7.3
98
37
RSSARSSAP08865P08865celladhesioncytoplasmictranslationribosomalsmallsubunitassemblytranslation
ADP-ribosylhydrolase ARH1
7.3
116
36
ADPRHADPRHP54922P54922activationofGTPaseactivityproteinde-ADP-ribosylationproteinmodificationprocessregulationofautophagosomeassembly
40S ribosomal protein S8
7.3
35
51
G1TJW1G1TJW1G1TJW1G1TJW1translation
Sorting nexin-27
7.3
66
48
✔
SNX27SNX27Q96L92Q96L92endocyticrecyclingendosomaltransportendosometolysosometransportestablishmentofnaturalkillercellpolarityintracellularproteintransportregulationofpostsynapticmembraneneurotransmitterreceptorlevelssignaltransduction
Probable ATP-dependent RNA helicase DDX5
7.3
71
45
DDX5DDX5P17844P17844alternativemRNAsplicingviaspliceosomeandrogenreceptorsignalingpathwayBMPsignalingpathwayepithelialtomesenchymaltransitionintracellularestrogenreceptorsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatormiRNAtranscriptionmRNAsplicingviaspliceosomemRNAtranscriptionmyoblastdifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInuclear-transcribedmRNAcatabolicprocesspositiveregulationofDNAdamageresponsesignaltransductionbyp53classmediatorprimarymiRNAprocessingregulationofalternativemRNAsplicingviaspliceosomeregulationofandrogenreceptorsignalingpathwayregulationofosteoblastdifferentiationregulationofskeletalmusclecelldifferentiationregulationoftranscriptionbyRNApolymeraseIIrhythmicprocess
Ral guanine nucleotide dissociation stimulator
5.4
57
60
GNDSGNDSQ03386Q03386positiveregulationofGTPaseactivityRasproteinsignaltransductionsmallGTPasemediatedsignaltransduction
Fizzy-related protein homolog
7.3
61
53
FZR1FZR1Q9UM11Q9UM11anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionDNArepairlensfibercelldifferentiationmitoticG2DNAdamagecheckpointsignalingnegativeregulationofcellularsenescencepositiveregulationofanaphase-promotingcomplex-dependentcatabolicprocesspositiveregulationofcellpopulationproliferationpositiveregulationofubiquitinproteinligaseactivityproteinK11-linkedubiquitinationregulationofmeioticcellcycleregulationofmeioticnucleardivisionregulationofmitoticcellcycle
Mitogen-activated protein kinase kinase kinase 14
7.3
91
40
M3K14M3K14Q99558Q99558cellularresponsetomechanicalstimulusdefenseresponsetovirusI-kappaBkinase/NF-kappaBsignalingimmuneresponseMAPKcascadeNIK/NF-kappaBsignalingpositiveregulationofI-kappaBkinase/NF-kappaBsignalingproteinphosphorylation
Neutral amino acid transporter B(0)
7.3
82
46
AAATAAATQ15758Q15758aminoacidtransportglutaminesecretionglutaminetransportL-aspartateimportacrossplasmamembraneL-glutamineimportacrossplasmamembraneneutralaminoacidtransportproteinhomotrimerizationtransportacrossblood-brainbarrier
40-kDa huntingtin-associated protein
7.3
67
50
✔
HAP40HAP40P23610P23610negativeregulationofproteasomalproteincatabolicprocessvesiclecytoskeletaltrafficking
Unconventional myosin-VIIa
9.5
59
38
MYO7AMYO7AQ13402Q13402actinfilamentorganizationactinfilament-basedmovementauditoryreceptorcellstereociliumorganizationequilibrioceptioneyephotoreceptorcelldevelopmentintracellularproteintransportlysosomeorganizationmechanoreceptordifferentiationphagolysosomeassemblypigmentgranuletransportpost-embryonicanimalorganmorphogenesisproteinlocalizationsensoryorgandevelopmentsensoryperceptionoflightstimulussensoryperceptionofsoundvesicletransportalongactinfilamentvisualperception
Apoptosis inhibitor 5
7.3
76
48
API5API5Q9BZZ5Q9BZZ5fibroblastapoptoticprocesslocalizationnegativeregulationofapoptoticprocessnegativeregulationoffibroblastapoptoticprocess
DNA-directed RNA polymerase I subunit RPA49
4.7
77
71
RPA2RPA49Q9H9Y6Q9GZS1embryoimplantationneuralcrestformationnucleologenesisrRNAtranscriptionnucleolarlargerRNAtranscriptionbyRNApolymeraseIRNApolymeraseIpreinitiationcomplexassemblytranscriptionelongationbyRNApolymeraseI
Nucleoporin Nup43
7.4
100
44
NUP43NUP43Q8NFH3Q8NFH3celldivisionchromosomesegregationmRNAtransportnucleocytoplasmictransportproteintransport
Hydroxymethylglutaryl-CoA synthase, mitochondrial
8.1
64
44
HMCS2HMCS2P54868P54868acetyl-CoAmetabolicprocessadiposetissuedevelopmentbraindevelopmentcellularresponsetoaminoacidstimuluscellularresponsetofattyacidcellularresponsetoglucocorticoidstimuluscellularresponsetoinsulinstimuluscellularresponsetolipopolysaccharidecholesterolbiosyntheticprocessfarnesyldiphosphatebiosyntheticprocessmevalonatepathwayketonebodybiosyntheticprocesskidneydevelopmentliverdevelopmentlungdevelopmentmidgutdevelopmentmulticellularorganismalresponsetostressresponsetocAMPresponsetoethanolresponsetoglucagonresponsetogrowthhormoneresponsetolinoleicacidresponsetometalionresponsetomonosaccharideresponsetonutrientresponsetoprostaglandinFresponsetostarvationresponsetotemperaturestimulusresponsetotestosteroneresponsetotriglycerideresponsetoxenobioticstimulus
Adenosine deaminase
7.3
87
42
ADAADAP00813P00813adenosinecatabolicprocessadenosinemetabolicprocessallantoinmetabolicprocessalpha-betaTcelldifferentiationamidecatabolicprocessAMPcatabolicprocessAMPsalvageBcellproliferationcalcium-mediatedsignalingcelladhesiondAMPcatabolicprocessdATPcatabolicprocessdeoxyadenosinecatabolicprocessembryonicdigestivetractdevelopmentgerminalcenterBcelldifferentiationgerminalcenterformationGMPsalvagehypoxanthinesalvageinosinebiosyntheticprocessleukocytemigrationliverdevelopmentlungalveolusdevelopmentmatureBcellapoptoticprocessmucussecretionnegativeregulationofadenosinereceptorsignalingpathwaynegativeregulationofinflammatoryresponsenegativeregulationofleukocytemigrationnegativeregulationofmatureBcellapoptoticprocessnegativeregulationofmucussecretionnegativeregulationofpenileerectionnegativeregulationofthymocyteapoptoticprocesspenileerection"Peyerspatchdevelopment"placentadevelopmentpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofBcellproliferationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofgerminalcenterformationpositiveregulationofheartratepositiveregulationofsmoothmusclecontractionpositiveregulationofTcelldifferentiationinthymuspositiveregulationofTcellreceptorsignalingpathwaypurinenucleotidesalvagepurine-containingcompoundsalvageregulationofcell-celladhesionmediatedbyintegrinresponsetohypoxiaresponsetoinorganicsubstanceresponsetopurine-containingcompoundsmoothmusclecontractionTcellactivationTcelldifferentiationinthymusTcellreceptorsignalingpathwaythymocyteapoptoticprocesstrophectodermalcelldifferentiationxanthinebiosyntheticprocessxenobioticmetabolicprocess
Acetyl-CoA carboxylase 1
7.3
61
51
ACACAACACAQ13085Q13085acetyl-CoAmetabolicprocesscellularresponsetoprostaglandinEstimulusfattyacidbiosyntheticprocessfatty-acyl-CoAbiosyntheticprocesslipidhomeostasismalonyl-CoAbiosyntheticprocessproteinhomotetramerizationproteinmetabolicprocesstissuehomeostasis
Protein S100-A3
2.0
nan
86
S10A3S10A3P33764P33764
Uridine phosphorylase 2
7.3
58
56
UPP2UPP2O95045O95045dCMPcatabolicprocessnucleosidemetabolicprocessUMPsalvageuridinecatabolicprocessuridinemetabolicprocess
Netrin receptor DCC
2.0
77
82
DCCDCCQ63155Q63155anterior/posterioraxonguidanceapoptoticprocessaxondevelopmentaxonguidancecell-celladhesioncerebralcortexdevelopmentcorpuscallosumdevelopmentdorsal/ventralaxonguidanceneuronmigrationopticnervedevelopmentpositiveregulationofERK1andERK2cascadepositiveregulationofneuronprojectiondevelopmentpostsynapticmodulationofchemicalsynaptictransmissionregulationofneurondeathresponsetoamphetaminespinalcordventralcommissuremorphogenesis
PAX-interacting protein 1
7.4
41
54
PAXI1PAXI1Q6ZW49Q6ZW49adiposetissuedevelopmentchoriondevelopmentDNAdamageresponsesignaltransductionbyp53classmediatorDNArecombinationDNArepairendothelialcellmigrationhistoneH3-K4methylationnegativeregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofhistoneH3-K4methylationpositiveregulationofisotypeswitchingpositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofproteinubiquitinationpositiveregulationofresponsetoDNAdamagestimuluspositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationofcellcycleG2/Mphasetransitionresponsetoionizingradiationvasculogenesis
Ubiquitin-like protein 3
7.4
14
64
UBL3UBL3O95164O95164
Guanine nucleotide-binding protein G(T) subunit gamma-T1
7.4
61
53
GBG1GBG1P63211P63211cardiacmusclecellapoptoticprocesscellularresponsetohypoxiaeyephotoreceptorcelldevelopmentGprotein-coupledreceptorsignalingpathwayphototransductionproteinlocalizationsignaltransduction
Interleukin enhancer-binding factor 2
7.4
75
45
ILF2ILF3Q9CXY6Q9Z1X4positiveregulationofDNA-templatedtranscriptiondefenseresponsetovirusnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranslationnegativeregulationofviralgenomereplicationproteinmethylationproteinphosphorylation
Thiopurine S-methyltransferase
7.4
74
41
TPMTTPMTP51580P51580methylationnucleobase-containingcompoundmetabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
Tyrosine-protein kinase receptor
8.7
65
41
B6EXY4B6EXY4B6EXY4B6EXY4transmembranereceptorproteintyrosinekinasesignalingpathway
Gamma-crystallin B
4.1
70
76
CRGBCRGBP07316P07316lensdevelopmentincamera-typeeyelensfibercellmorphogenesisvisualperception
Rho guanine nucleotide exchange factor 6
7.4
59
55
ARHG6ARHG6Q15052Q15052apoptoticprocessJNKcascadelamellipodiumassembly
PAS domain-containing serine/threonine-protein kinase
7.4
51
55
PASKPASKQ96RG2Q96RG2energyhomeostasisintracellularsignaltransductionnegativeregulationofglycogenbiosyntheticprocesspositiveregulationoftranslationproteinautophosphorylationproteinphosphorylationregulationofglucagonsecretionregulationofrespiratorygaseousexchange
Dynamin-1
7.4
78
44
DYN1DYN1Q05193Q05193endocytosisendosomeorganizationmodulationofchemicalsynaptictransmissionreceptorinternalizationreceptor-mediatedendocytosissynapticvesiclebuddingfrompresynapticendocyticzonemembranesynapticvesicleendocytosistoxintransport
Mitogen-activated protein kinase kinase kinase 20
7.4
66
47
M3K20M3K20Q9NYL2Q9NYL2cellcyclecelldeathcelldifferentiationcellularresponsetogammaradiationcellularresponsetoUV-BcytoskeletonorganizationDNAdamagecheckpointsignalingembryonicdigitmorphogenesisGCN2-mediatedsignalingJNKcascadelimbdevelopmentp38MAPKcascadepeptidyl-serinephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofmitoticDNAdamagecheckpointpositiveregulationofprogrammedcelldeathproteinautophosphorylationproteinphosphorylationpyroptosisstress-activatedMAPKcascadestress-activatedproteinkinasesignalingcascade
Receptor-type tyrosine-protein phosphatase alpha
7.4
51
55
PTPRAPTPRAP18433P18433insulinreceptorsignalingpathwayintegrin-mediatedsignalingpathwaymodulationofchemicalsynaptictransmissionproteindephosphorylationproteinphosphorylationregulationoffocaladhesionassembly
SUMO-conjugating enzyme UBC9
2.0
78
82
✔
UBC9RAGP1P63279P46061celldivisionchromosomesegregationmitoticnuclearmembranereassemblynegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInuclearexportpositiveregulationofcellmigrationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofSUMOtransferaseactivityproteinmodificationprocessproteinsumoylationubiquitin-dependentproteincatabolicprocessactivationofGTPaseactivitycellularresponsetopeptidehormonestimuluscellularresponsetovasopressinnegativeregulationofproteinexportfromnucleusnucleocytoplasmictransportresponsetoaxoninjurysignaltransduction
5-hydroxytryptamine receptor 1A
2.0
53
87
5HT1A5HT1AP08908P08908adenylatecyclase-inhibitingserotoninreceptorsignalingpathwaybehavioralfearresponsechemicalsynaptictransmissionexplorationbehaviorGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengergamma-aminobutyricacidsignalingpathwaypositiveregulationofcellpopulationproliferationregulationofbehaviorregulationofdopaminemetabolicprocessregulationofhormonesecretionregulationofserotoninsecretionregulationofvasoconstrictionserotoninmetabolicprocessserotoninreceptorsignalingpathway
Intersectin-1
7.4
73
40
ITSN1ITSN1Q9Z0R4Q9Z0R4clathrin-dependentsynapticvesicleendocytosisendocytosisendosomaltransportexocytosisnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofcaveolin-mediatedendocytosispositiveregulationofdendriticspinedevelopmentpositiveregulationofgrowthhormonesecretionpositiveregulationofproteinkinaseBsignalingproteinlocalizationproteintransportregulationofmodificationofpostsynapticactincytoskeletonregulationofpostsynapseorganizationsmallGTPasemediatedsignaltransductionsynapticvesicleendocytosis
Integrator complex subunit 5
7.8
74
42
INT5INT5Q6P9B9Q6P9B9regulationoftranscriptionelongationbyRNApolymeraseII"snRNA3-endprocessing"snRNAprocessing
Serine/threonine-protein kinase Nek1
2.1
76
82
NEK1NEK1Q96PY6Q96PY6cellcyclecelldivisionciliumassemblyproteinphosphorylation
Uridine phosphorylase 1
7.4
79
43
UPP1UPP1Q16831Q16831cellularresponsetoglucosestarvationCMPcatabolicprocessdCMPcatabolicprocessdTMPcatabolicprocessdUMPcatabolicprocessnucleobase-containingcompoundmetabolicprocessUMPcatabolicprocessUMPsalvageuridinecatabolicprocess
Endophilin-A3
7.4
58
54
SH3G3SH3G3Q99963Q99963centralnervoussystemdevelopmentnegativeregulationofclathrin-dependentendocytosispositiveregulationofneurondifferentiationsignaltransductionsynapticvesicleuncoating
Centromere/kinetochore protein zw10 homolog
7.4
72
44
ZW10ZW10O43264O43264celldivisionendoplasmicreticulumtoGolgivesicle-mediatedtransportestablishmentofmitoticspindleorientationGolgiorganizationmeioticcellcyclemitoticmetaphaseplatecongressionmitoticsisterchromatidsegregationmitoticspindleassemblycheckpointsignalingproteinlocalizationtokinetochoreproteintransportprotein-containingcomplexassemblyregulationofexitfrommitosisretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Msx2-interacting protein
7.4
65
50
MINTMINTQ96T58Q96T58negativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIINotchsignalingpathwaypositiveregulationofneurogenesisregulationoftranscriptionbyRNApolymeraseII
Sorbitol dehydrogenase
6.8
85
43
✔
DHSODHSOQ00796Q00796flagellatedspermmotilityfructosebiosyntheticprocessglucosemetabolicprocessglucuronatecatabolicprocesstoxylulose5-phosphateL-xylitolcatabolicprocessL-xylitolmetabolicprocessresponsetocadmiumionresponsetocopperionresponsetohormoneresponsetonutrientlevelsresponsetoosmoticstressresponsetoxenobioticstimulussorbitolcatabolicprocess
AP-2 complex subunit alpha-2
7.4
52
57
AP2A2AP2A2P17427P17427clathrin-dependentendocytosisintracellularproteintransportpostsynapticneurotransmitterreceptorinternalizationregulationofhematopoieticstemcelldifferentiationvesicle-mediatedtransport
Tubulin alpha-1B chain
2.1
76
83
VASH2TBA1BQ86V25P68363axondevelopmentcell-cellfusionlabyrinthinelayerbloodvesseldevelopmentpositiveregulationofangiogenesispositiveregulationofendothelialcellproliferationproteolysisregulationofangiogenesissyncytiumformationbyplasmamembranefusioncelldivisioncellularresponsetointerleukin-4cytoskeleton-dependentintracellulartransportmicrotubulecytoskeletonorganizationmicrotubule-basedprocessmitoticcellcycle
Serine/threonine-protein kinase PLK2
7.4
59
51
PLK2PLK2Q9NYY3Q9NYY3DNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestG1/Stransitionofmitoticcellcyclelong-termsynapticdepressionlong-termsynapticpotentiationmemorymitoticcellcyclemitoticspindleorganizationnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofapoptoticprocessinbonemarrowcellnegativeregulationofcellularsenescencenegativeregulationofinflammatoryresponsetoantigenicstimuluspeptidyl-serinephosphorylationpositiveregulationofautophagypositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteincatabolicprocessproteinphosphorylationRapproteinsignaltransductionRasproteinsignaltransductionregulationofcentriolereplicationregulationofcytokinesisregulationofsynapticplasticity
Thymidylate kinase
7.5
65
50
✔
KTHYKTHYP23919P23919cellularresponsetogrowthfactorstimulusdTDPbiosyntheticprocessdTTPbiosyntheticprocessdUDPbiosyntheticprocessphosphorylationthymidinebiosyntheticprocess
O-phosphoseryl-tRNA(Sec) selenium transferase
4.4
68
67
SPCSSPCSQ6P6M7Q6P6M7selenocysteineincorporationselenocysteinyl-tRNA(Sec)biosyntheticprocess
Protein ELYS
7.8
59
49
ELYSELYSQ8CJF7Q8CJF7cellcyclecelldivisionhemopoiesismRNAtransportnuclearporecomplexassemblynucleocytoplasmictransportproteintransportregulationofcytokinesis
N-alpha-acetyltransferase 50
7.7
66
45
✔
NAA50NAA50Q9GZZ1Q9GZZ1establishmentofmitoticsisterchromatidcohesionhistoneacetylationmitoticsisterchromatidcohesionmitoticsisterchromatidcohesioncentromericN-terminalproteinaminoacidacetylation
Cytochrome P450 1A1
8.7
50
47
CP1A1CP1A1P04798P047989-cis-retinoicacidbiosyntheticprocessagingaminemetabolicprocesscamera-typeeyedevelopmentcellpopulationproliferationcellularresponsetocopperioncellularresponsetoorganiccycliccompoundcoumarinmetabolicprocessdibenzo-p-dioxincatabolicprocessdigestivetractdevelopmentDNAmethylationepoxygenaseP450pathwayestrogenmetabolicprocessethylenemetabolicprocessfattyacidmetabolicprocessflavonoidmetabolicprocesshepatocytedifferentiationhydrogenperoxidebiosyntheticprocessinsecticidemetabolicprocesslipidhydroxylationlong-chainfattyacidbiosyntheticprocesslong-chainfattyacidmetabolicprocessmaternalprocessinvolvedinparturitionomega-hydroxylaseP450pathwayporphyrin-containingcompoundmetabolicprocesspositiveregulationofG1/Stransitionofmitoticcellcycleresponsetoantibioticresponsetoarsenic-containingsubstanceresponsetofoodresponsetoherbicideresponsetohyperoxiaresponsetohypoxiaresponsetoimmobilizationstressresponsetoiron(III)ionresponsetolipopolysaccharideresponsetonematoderesponsetovirusresponsetovitaminAresponsetowoundingretinolmetabolicprocesssteroidbiosyntheticprocesssteroidmetabolicprocessvitaminDmetabolicprocessxenobioticmetabolicprocess
THO complex subunit 3
3.6
83
79
THOC2THOC3Q8NI27Q96J01generationofneuronsmRNAexportfromnucleusmRNAprocessingneurondevelopmentpoly(A)+mRNAexportfromnucleusRNAsplicingviralmRNAexportfromhostcellnucleus
Ataxin-3-like protein
7.5
88
39
ATX3LATX3LQ9H3M9Q9H3M9proteindeubiquitination
ADP-ribosylation factor-like protein 5A
7.5
78
48
ARL5AARL5AQ9Y689Q9Y689intracellularproteintransportproteinlocalizationtoGolgimembranevesicle-mediatedtransport
Cell death activator CIDE-B
7.5
56
53
CIDEBCIDEBQ9UHD4Q9UHD4activationofcysteine-typeendopeptidaseactivityapoptoticprocessbileacidsignalingpathwayexecutionphaseofapoptosisintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagepositiveregulationofcelldeathpositiveregulationofreleaseofcytochromecfrommitochondriaregulationofapoptoticprocessresponsetonutrientlevels
Kelch domain-containing protein 2
9.0
77
36
KLDC2KLDC2Q9Y2U9Q9Y2U9proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathway
Insulin-induced gene 2 protein
7.5
47
50
INSI2INSI2Q9Y5U4Q9Y5U4cellularresponsetoinsulinstimuluscholesterolbiosyntheticprocesscranialsuturemorphogenesisinnerearmorphogenesismiddleearmorphogenesisnegativeregulationoffattyacidbiosyntheticprocessnegativeregulationofsteroidbiosyntheticprocessresponsetofattyacidroofofmouthdevelopmentSREBPsignalingpathwaySREBP-SCAPcomplexretentioninendoplasmicreticulumsterolbiosyntheticprocesstriglyceridemetabolicprocess
BTB/POZ domain-containing protein KCTD12
5.6
nan
75
KCD12KCD12Q96CX2Q96CX2proteinhomooligomerization
Rab GDP dissociation inhibitor alpha
4.4
90
60
GDIAGDIAP21856P21856negativeregulationofaxonogenesisnegativeregulationofproteintargetingtomembraneproteintransportRabproteinsignaltransductionvesicle-mediatedtransport
U1 small nuclear ribonucleoprotein C
3.3
54
83
RU1CRU1CP09234P09234"mRNA5-splicesiterecognition"mRNAsplicingviaspliceosomespliceosomalsnRNPassembly
Myotilin
7.5
60
52
MYOTIMYOTIQ9UBF9Q9UBF9homophiliccelladhesionviaplasmamembraneadhesionmoleculesmusclecontractionsynapseorganization
Nuclear RNA export factor 1
7.5
88
40
NXF1NXT1Q9UBU9Q9UKK6mRNAexportfromnucleuspoly(A)+mRNAexportfromnucleusproteintransportnucleocytoplasmictransportproteinexportfromnucleusproteinimportintonucleus
Serine/threonine-protein kinase MRCK beta
7.5
78
42
MRCKBMRCKBQ9Y5S2Q9Y5S2actincytoskeletonreorganizationactomyosinstructureorganizationcellmigrationcytoskeletonorganizationestablishmentormaintenanceofcellpolaritypeptidyl-threoninephosphorylationproteinphosphorylationsignaltransduction
Tyrosine-protein phosphatase non-receptor type 5
7.5
82
41
PTN5PTN5P54829P54829peptidyl-tyrosinedephosphorylationproteindephosphorylationsignaltransduction
THO complex subunit 5 homolog
7.5
69
47
✔
THOC5THOC7Q13769Q6I9Y2monocytedifferentiationmRNAexportfromnucleusmRNAprocessingnegativeregulationofDNAdamagecheckpointpositiveregulationofDNA-templatedtranscriptionelongationprimitivehemopoiesisRNAsplicingviralmRNAexportfromhostcellnucleus
CUGBP Elav-like family member 2
7.5
47
59
CELF2CELF2O95319O95319mRNAsplicesiteselectionregulationofalternativemRNAsplicingviaspliceosomeregulationofheartcontractionRNAprocessing
Tubulin polymerization-promoting protein family member 3
7.5
78
42
TPPP3TPPP3Q9CRB6Q9CRB6decidualizationembryoimplantationmicrotubulebundleformationmicrotubulepolymerizationpositiveregulationofproteinpolymerization
Myotubularin-related protein 1
7.5
71
47
MTMR1MTMR1Q13613Q13613phosphatidylinositolbiosyntheticprocessphosphatidylinositoldephosphorylationregulationofphosphatidylinositoldephosphorylation
Calpain-2 catalytic subunit
7.5
76
42
CAN2CAN2Q07009Q07009behavioralresponsetopainblastocystdevelopmentcellularresponsetoaminoacidstimuluscellularresponsetointerferon-betacellularresponsetolipopolysaccharidefemalepregnancymyoblastfusionpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofmyoblastfusionpositiveregulationofneurondeathpositiveregulationofphosphatidylcholinebiosyntheticprocessproteinautoprocessingproteincatabolicprocessproteolysisproteolysisinvolvedinproteincatabolicprocessregulationofinterleukin-6productionresponsetohydrogenperoxideresponsetohypoxiaresponsetomechanicalstimulus
Folliculin-interacting protein 2
7.5
67
49
FNIP2FNIP2Q9P278Q9P278intrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofprotein-containingcomplexassemblyproteinphosphorylationregulationofproteinphosphorylation
Protein arginine N-methyltransferase 9
7.5
61
52
ANM9ANM9Q6P2P2Q6P2P2mRNAprocessingpeptidyl-argininemethylation
Mitochondrial translation release factor in rescue
7.5
61
54
MTRFRMTRFRQ80VP5Q80VP5rescueofstalledribosome
Proteasome 26S subunit, ATPase 6
7.5
65
47
G3V6W6G3V6W6G3V6W6G3V6W6positiveregulationofinclusionbodyassemblypositiveregulationofRNApolymeraseIItranscriptionpreinitiationcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessubiquitin-dependentERADpathway
26S proteasome non-ATPase regulatory subunit 14
7.5
82
38
✔
PSDEPSDEO00487O00487double-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeubiquitinationproteinK63-linkeddeubiquitinationregulationofproteasomalproteincatabolicprocessresponsetoethanolubiquitin-dependentproteincatabolicprocess
Dual specificity protein phosphatase 6
7.5
55
57
DUS6DUS6Q16828Q16828celldifferentiationERK1andERK2cascadeMAPKcascadenegativeregulationofERK1andERK2cascadenegativeregulationofMAPKcascadenegativeregulationofproteinphosphorylationpeptidyl-tyrosinedephosphorylationpositiveregulationofapoptoticprocessregulationofheartgrowthresponsetogrowthfactorresponsetonitrosativestressresponsetoorganiccycliccompoundresponsetoxenobioticstimulus
Piezo-type mechanosensitive ion channel component 1
2.0
44
89
PIEZ1PIEZ1E2JF22E2JF22cationtransportcellularresponsetomechanicalstimulusdetectionofmechanicalstimuluspositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofintegrinactivationpositiveregulationofmyotubedifferentiationregulationofmembranepotential
Glutamate receptor ionotropic, kainate 2
2.1
60
81
GRIK2GRIK2P42260P42260behavioralfearresponsecellularcalciumionhomeostasischemicalsynaptictransmissiondetectionofcoldstimulusinvolvedinthermoceptionexcitatorypostsynapticpotentialinhibitorypostsynapticpotentialiontransmembranetransportionotropicglutamatereceptorsignalingpathwaymodulationofchemicalsynaptictransmissionmodulationofexcitatorypostsynapticpotentialnegativeregulationofneuronapoptoticprocessnegativeregulationofsynaptictransmissionglutamatergicneuronapoptoticprocessneuronalactionpotentialpositiveregulationofneuronapoptoticprocesspositiveregulationofsynaptictransmissionpotassiumiontransmembranetransportpresynapticmodulationofchemicalsynaptictransmissionreceptorclusteringregulationofJNKcascaderegulationoflong-termneuronalsynapticplasticityregulationofmembranepotentialregulationofpostsynapticmembranepotentialregulationofshort-termneuronalsynapticplasticitysodiumiontransmembranetransportsynaptictransmissionglutamatergic
RNA polymerase I-specific transcription initiation factor RRN3
7.5
75
43
RRN3RRN3Q9NYV6Q9NYV6cytoplasmorganizationfibroblastproliferationhomeostasisofnumberofcellsinuteroembryonicdevelopmentintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatornucleolusorganizationpositiveregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscriptioninitiationribosomebiogenesistranscriptioninitiationatRNApolymeraseIpromoter
Nuclear receptor subfamily 2 group C member 2
7.5
53
51
NR2C2NR2C2P49116P49116anatomicalstructuredevelopmentcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpositiveregulationofembryonicdevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIspermatogenesis
Phenylalanine--tRNA ligase beta subunit
7.5
87
39
SYFBSYFBQ9NSD9Q9NSD9phenylalanyl-tRNAaminoacylationproteinheterotetramerizationtranslation
Enhancer of filamentation 1
7.5
28
59
✔
CASLCASLQ14511Q14511actinfilamentbundleassemblyactinfilamentreorganizationactivationofGTPaseactivitycelladhesioncellcyclecelldivisioncellmigrationciliumdisassemblycytoskeletonorganizationintegrin-mediatedsignalingpathwaylearningormemorylymphocytemigrationintolymphoidorgansnegativeregulationofcellmigrationpositiveregulationofcellmigrationpositiveregulationofdendriticspinemaintenancepositiveregulationofimmunologicalsynapseformationpositiveregulationoflymphocytechemotaxispositiveregulationofosteoclastdifferentiationpositiveregulationofproteinlocalizationpositiveregulationofproteintyrosinekinaseactivitypositiveregulationofsubstrateadhesion-dependentcellspreadingregulationofactincytoskeletonorganizationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Phospholipase A-2-activating protein
4.6
80
69
PLAPPLAPQ9Y263Q9Y263cellularresponsetolipopolysaccharideinflammatoryresponsemacroautophagynegativeregulationofproteinK63-linkedubiquitinationnervoussystemdevelopmentphospholipidmetabolicprocesspositiveregulationofdendriteextensionpositiveregulationofneuronmigrationpositiveregulationofphospholipaseA2activitypositiveregulationofsynapticvesiclerecyclingprostaglandinmetabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocesssignaltransductionubiquitinrecyclingubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Interleukin-1 family member 10
7.6
43
55
IL1FAIL1FAQ8WWZ1Q8WWZ1cellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwayinflammatoryresponseinflammatoryresponsetoantigenicstimuluspositiveregulationofgeneexpression
ATP-dependent 6-phosphofructokinase, platelet type
8.0
68
46
PFKAPPFKAPQ01813Q01813canonicalglycolysiscellularresponsetoleukemiainhibitoryfactorfructose16-bisphosphatemetabolicprocessfructose6-phosphatemetabolicprocess
Oxysterol-binding protein 1
2.0
84
80
OSBP1OSBP1P22059P22059bileacidbiosyntheticprocessceramidetransportintracellularcholesteroltransportphospholipidtransportpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofsecretorygranuleorganizationpositiveregulationoftyrosinephosphorylationofSTATproteinsphingomyelinbiosyntheticprocesssteroltransport
Kelch-like protein 11
7.6
70
50
KLH11KLH11Q9NVR0Q9NVR0
Aldo-keto reductase family 1 member A1
7.6
88
41
AK1A1AK1A1Q9JII6Q9JII6aldehydecatabolicprocesscellulardetoxificationofaldehydeD-glucuronatecatabolicprocessdaunorubicinmetabolicprocessdoxorubicinmetabolicprocessglucuronatecatabolicprocesstoxylulose5-phosphateL-ascorbicacidbiosyntheticprocesslipidmetabolicprocess
Glutaryl-CoA dehydrogenase, mitochondrial
7.6
47
55
GCDHGCDHQ92947Q92947fattyacidbeta-oxidationusingacyl-CoAdehydrogenasefatty-acyl-CoAbiosyntheticprocesstryptophanmetabolicprocess
Transformer-2 protein homolog beta
7.6
64
53
✔
TRA2BTRA2BP62995P62995cellularresponsetoglucosestimuluscerebralcortexregionalizationembryonicbraindevelopmentmRNAsplicingviaspliceosomepositiveregulationofmRNAsplicingviaspliceosomeregulationofalternativemRNAsplicingviaspliceosomeregulationofRNAsplicingRNAsplicingviatransesterificationreactions
Phospholipase A and acyltransferase 4
7.6
41
56
PLAT4PLAT4Q9UL19Q9UL19lipidcatabolicprocessN-acylphosphatidylethanolaminemetabolicprocessnegativeregulationofcellpopulationproliferationphosphatidylethanolamineacyl-chainremodelingphospholipidmetabolicprocesspositiveregulationofkeratinocytedifferentiationpositiveregulationofprotein-glutaminegamma-glutamyltransferaseactivity
Hsp90 co-chaperone Cdc37
7.6
45
57
CDC37CDC37Q16543Q16543positiveregulationofmitophagyinresponsetomitochondrialdepolarizationpost-transcriptionalregulationofgeneexpressionproteinfoldingproteinstabilizationproteintargetingregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationoftypeIinterferon-mediatedsignalingpathwayregulationoftypeIIinterferon-mediatedsignalingpathway
Beta-ureidopropionase
2.0
44
86
BUP1BUP1Q9UBR1Q9UBR1beta-alaninebiosyntheticprocessvia3-ureidopropionateCMPcatabolicprocessdCMPcatabolicprocessdUMPcatabolicprocessinuteroembryonicdevelopmentliverdevelopmentproteinhomooligomerizationproteinhomotetramerizationpyrimidinenucleosidecatabolicprocessUMPcatabolicprocess
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
7.6
94
36
✔
DNPH1DNPH1O43598O43598deoxyribonucleosidemonophosphatecatabolicprocessepithelialcelldifferentiationnucleosidemetabolicprocesspositiveregulationofcellgrowthpurinenucleotidecatabolicprocess
Transmembrane protein 141
7.6
43
56
TM141TM141Q96I45Q96I45
tRNA-splicing endonuclease subunit Sen15
7.6
74
45
SEN15SEN15Q8WW01Q8WW01mRNAprocessingtRNAsplicingviaendonucleolyticcleavageandligation
Serine/threonine-protein kinase MRCK alpha
9.8
52
46
MRCKAMRCKAO54874O54874actincytoskeletonreorganizationactomyosinstructureorganizationcellmigrationcytoskeletonorganizationmicrotubulecytoskeletonorganizationnuclearmigrationpeptidyl-threoninephosphorylationproteinphosphorylationregulationofsmallGTPasemediatedsignaltransduction
Low-density lipoprotein receptor class A domain-containing protein 3
2.0
nan
88
LRAD3LRAD3Q86YD5Q86YD5receptor-mediatedendocytosisregulationofproteinprocessing
IQGAP1 protein
7.6
77
40
Q6P1N4Q6P1N4Q6P1N4Q6P1N4
Peripherin-2
7.7
81
47
PRPH2ROM1P23942Q03395celladhesiondetectionoflightstimulusinvolvedinvisualperceptionphotoreceptorcelloutersegmentorganizationproteinheterooligomerizationproteinhomooligomerizationresponsetolowlightintensitystimulusretinadevelopmentincamera-typeeyevisualperceptioncamera-typeeyephotoreceptorcelldifferentiationproteinlocalizationtophotoreceptoroutersegmentregulationofgeneexpressionretinavasculaturedevelopmentincamera-typeeye
cAMP-dependent protein kinase type I-beta regulatory subunit
2.0
47
87
KAP1KAP1P31321P31321learningormemorynegativeregulationofcAMP-dependentproteinkinaseactivitypositiveregulationofexcitatorypostsynapticpotentialpositiveregulationoffearresponsepositiveregulationoflong-termsynapticpotentiationpositiveregulationofsensoryperceptionofpainproteinphosphorylationregulationofsynapticvesiclecycle
Mediator of RNA polymerase II transcription subunit 11
7.6
61
49
✔
MED11MED22Q9P086Q15528positiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassembly
Receptor-type tyrosine-protein phosphatase-like N
7.6
61
51
PTPRNPTPRNQ16849Q16849densecoregranulematurationinsulinsecretioninsulinsecretioninvolvedincellularresponsetoglucosestimulusluteinizationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeBpancreaticcellproliferationregulationofsecretionresponsetoreactiveoxygenspecies
Atlastin-3
7.6
60
53
ATLA3ATLA3Q6DD88Q6DD88endoplasmicreticulumorganizationGolgiorganizationpositiveregulationofendoplasmicreticulumtubularnetworkorganizationproteinhomooligomerization
DDB1- and CUL4-associated factor 12
7.2
nan
59
DCA12DCA12Q5T6F0Q5T6F0proteinubiquitinationregulationofautophagyubiquitin-dependentproteincatabolicprocessviatheC-enddegronrulepathway
Calpain-3
7.6
72
47
CAN3CAN3P20807P20807apoptoticprocesscalcium-dependentselfproteolysiscellularresponsetocalciumioncellularresponsetosaltstressG1toG0transitioninvolvedincelldifferentiationmusclecellcellularhomeostasismuscleorgandevelopmentmusclestructuredevelopmentmyofibrilassemblynegativeregulationofapoptoticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofproteinsumoylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteolysispositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsatellitecellactivationinvolvedinskeletalmuscleregenerationproteincatabolicprocessproteindestabilizationproteinlocalizationtomembraneprotein-containingcomplexassemblyproteolysisregulationofcatalyticactivityregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmyoblastdifferentiationresponsetocalciumionresponsetomuscleactivitysarcomereorganizationselfproteolysis
Protein RD3
7.6
69
53
RD3RD3Q7Z3Z2Q7Z3Z2negativeregulationofguanylatecyclaseactivityproteintransportresponsetostimulusretinadevelopmentincamera-typeeyevisualperception
Translation initiation factor IF-2, mitochondrial
7.7
81
44
IF2MIF2MP46198P46198mitochondrialtranslationalinitiationribosomedisassemblytranslationalinitiation
Dual specificity protein phosphatase 18
7.7
81
43
DUS18DUS18Q8NEJ0Q8NEJ0dephosphorylationpeptidyl-threoninedephosphorylationpeptidyl-tyrosinedephosphorylation
Ras and EF-hand domain-containing protein
7.7
78
47
RASEFRASEFQ8IZ41Q8IZ41
Endophilin-B1
7.7
68
39
SHLB1SHLB1Q9Y371Q9Y371apoptoticprocessautophagiccelldeathautophagycellularresponsetoaminoacidstarvationcellularresponsetoglucosestarvationmembranefissionmembraneorganizationpositiveregulationofautophagosomeassemblypositiveregulationofautophagypositiveregulationofmembranetubulationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofprotein-containingcomplexassemblyproteinlocalizationtovacuolarmembranereceptorcatabolicprocessregulationofcytokinesisregulationofmacroautophagyregulationofproteinstability
Unconventional myosin-Vb
7.7
65
48
MYO5BMYO5BQ9ULV0Q9ULV0actinfilamentorganizationendosomaltransportproteintransportrenalwaterhomeostasisvesicletransportalongactinfilamentvesicle-mediatedtransport
Ubiquitin-like protein 5
7.7
78
41
UBL5UBL5Q9BZL1Q9BZL1mRNAsplicingviaspliceosomepositiveregulationofproteintargetingtomitochondrionproteinmodificationprocess
Inositol-tetrakisphosphate 1-kinase
5.1
75
63
ITPK1ITPK1Q13572Q13572bloodcoagulationinositolphosphorylationinositoltrisphosphatemetabolicprocessnecroptoticprocessneuraltubedevelopmentsignaltransduction
Glycogenin-2
7.7
81
41
GLYG2GLYG2O15488O15488glycogenbiosyntheticprocess
Ganglioside-induced differentiation-associated protein 2
7.7
71
47
GDAP2GDAP2Q9NXN4Q9NXN4responsetoretinoicacid
Eukaryotic translation initiation factor 4 gamma 2
7.7
73
41
✔
IF4G2IF4G2P78344P78344celldeathcellularmacromoleculebiosyntheticprocessnegativeregulationofautophagypositiveregulationofcellgrowthregulationofcellcycleregulationoftranslationalinitiation
Calpain-13
7.7
70
43
CAN13CAN13Q17RF0Q17RF0negativeregulationofapoptoticprocessproteolysis
Polyunsaturated fatty acid 5-lipoxygenase
7.7
48
53
LOX5LOX5P09917P09917arachidonicacidmetabolicprocessdendriticcellmigrationglucosehomeostasishepoxilinbiosyntheticprocesshumoralimmuneresponseleukocytechemotaxisinvolvedininflammatoryresponseleukocytemigrationinvolvedininflammatoryresponseleukotrieneA4biosyntheticprocessleukotrienebiosyntheticprocessleukotrienemetabolicprocessleukotrieneproductioninvolvedininflammatoryresponselinoleicacidmetabolicprocesslipidoxidationlipoxinbiosyntheticprocesslipoxygenasepathwaylong-chainfattyacidbiosyntheticprocessnegativeregulationofangiogenesisnegativeregulationofendothelialcellproliferationnegativeregulationofinflammatoryresponsenegativeregulationofresponsetoendoplasmicreticulumstressnegativeregulationofsproutingangiogenesisnegativeregulationofvascularwoundhealingnegativeregulationofwoundhealingpositiveregulationofbonemineralizationpositiveregulationofleukocyteadhesiontoarterialendothelialcellregulationofcellularresponsetooxidativestressregulationofcytokineproductioninvolvedininflammatoryresponseregulationoffatcelldifferentiationregulationofinflammatoryresponseregulationofinflammatoryresponsetowoundingregulationofinsulinsecretionregulationofreactiveoxygenspeciesbiosyntheticprocess
TIR domain-containing adapter molecule 1
7.7
57
50
TCAM1TCAM1Q8IUC6Q8IUC6apoptoticsignalingpathwayBcellproliferationcellularresponsetolipopolysaccharidecellularresponsetooxidisedlow-densitylipoproteinparticlestimulusdefenseresponsetovirusI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaymacrophageactivationinvolvedinimmuneresponsenitricoxidebiosyntheticprocesspositiveregulationofautophagypositiveregulationofBcellproliferationpositiveregulationofchemokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofnaturalkillercellactivationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofproteinbindingpositiveregulationofproteinubiquitinationpositiveregulationoftumornecrosisfactorproductionregulationofprotein-containingcomplexassemblyresponsetoexogenousdsRNATRIF-dependenttoll-likereceptorsignalingpathway
Aldehyde dehydrogenase 1 family, member A1, isoform CRA_a
7.7
83
44
V9HW83V9HW83V9HW83V9HW83
ADP-ribose glycohydrolase MACROD2
8.0
69
46
MACD2MACD2A1Z1Q3A1Z1Q3braindevelopmentcellularresponsetoDNAdamagestimuluspeptidyl-glutamateADP-deribosylationproteinde-ADP-ribosylationpurinenucleosidemetabolicprocessresponsetobacterium
Tubulin beta chain
8.7
48
48
A0A0R4I995A0A0R4I995A0A0R4I995A0A0R4I995microtubule-basedprocess
Partner and localizer of BRCA2
7.7
67
44
PALB2PALB2Q86YC2Q86YC2animalorganmorphogenesisapoptoticprocessdouble-strandbreakrepairviahomologousrecombinationembryonicorgandevelopmentinnercellmasscellproliferationmesodermdevelopmentmulticellularorganismgrowthnegativeregulationofapoptoticprocesspost-analtailmorphogenesissomitogenesis
Prostaglandin reductase 1
2.0
86
81
✔
PTGR1PTGR1Q9EQZ5Q9EQZ5leukotrieneB4metabolicprocesslipoxinA4metabolicprocessprostaglandinmetabolicprocess
Kinesin light chain
7.7
75
43
Q5UE59Q5UE59Q5UE59Q5UE59
Ubiquitin carboxyl-terminal hydrolase isozyme L1
8.5
57
49
UCHL1UCHL1P09936P09936adultwalkingbehavioraxontargetrecognitionaxonaltransportofmitochondrioncellularresponsetoxenobioticstimuluseatingbehaviormalegermcellproliferationmusclecelldevelopmentnegativeregulationofMAPkinaseactivityneuromuscularprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeubiquitinationregulationofmacroautophagyresponsetoischemiasensoryperceptionofpain
Transitional endoplasmic reticulum ATPase
7.7
66
47
TERATERAQ01853Q01853activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessaggresomeassemblyATPmetabolicprocessautophagosomematurationautophagycellularresponsetoarseniteioncellularresponsetoDNAdamagestimuluscellularresponsetoheatDNArepairdouble-strandbreakrepairendoplasmicreticulumstress-inducedpre-emptivequalitycontrolendoplasmicreticulumtoGolgivesicle-mediatedtransportendosometolysosometransportviamultivesicularbodysortingpathwayER-associatedmisfoldedproteincatabolicprocessERADpathwayflavinadeninedinucleotidecatabolicprocessinterstrandcross-linkrepairmacroautophagymitoticspindledisassemblyNADHmetabolicprocessnegativeregulationofsmoothenedsignalingpathwaypositiveregulationofATPbiosyntheticprocesspositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofLys63-specificdeubiquitinaseactivitypositiveregulationofmitochondrialmembranepotentialpositiveregulationofoxidativephosphorylationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteincatabolicprocesspositiveregulationofproteinK63-linkeddeubiquitinationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofubiquitin-dependentproteincatabolicprocessproteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationprotein-DNAcovalentcross-linkingrepairregulationofaerobicrespirationregulationofproteinlocalizationtochromatinregulationofsynapseorganizationretrogradeproteintransportERtocytosolstressgranuledisassemblytranslesionsynthesisubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocessviralgenomereplication
Pyruvate kinase PKLR
7.7
72
43
KPYRKPYRP30613P30613ATPbiosyntheticprocesscellularresponsetoepinephrinestimuluscellularresponsetoinsulinstimulusglycolyticprocesspyruvatebiosyntheticprocessresponsetoATPresponsetocAMPresponsetoglucoseresponsetoheatresponsetohypoxiaresponsetolithiumionresponsetonutrient
G1/S-specific cyclin-E1
7.8
76
41
CCNE1CCNE1P24864P24864celldivisionDNAreplicationinitiationG1/StransitionofmitoticcellcyclehomologouschromosomepairingatmeiosismitoticcellcyclephasetransitionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofmesenchymalstemcellproliferationproteinphosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofproteinlocalizationtelomeremaintenanceWntsignalingpathway
Structural maintenance of chromosomes protein 1A
7.7
71
43
SMC1ASMC1AQ9CU62Q9CU62celldivisionDNArepairmeioticcellcyclemitoticspindleassemblyresponsetoDNAdamagecheckpointsignalingresponsetoradiationsisterchromatidcohesionsomaticstemcellpopulationmaintenance
CDC42BPB protein
7.7
78
44
Q86XZ8Q86XZ8Q86XZ8Q86XZ8proteinphosphorylation
eIF-2-alpha kinase GCN2
7.7
48
53
✔
E2AK4E2AK4Q9P2K8Q9P2K8adaptiveimmuneresponsecellcyclecellularresponsetoaminoacidstarvationcellularresponsetocoldcellularresponsetoleucinestarvationcellularresponsetoUVdefenseresponsetovirusDNAdamagecheckpointsignalingeiF2alphaphosphorylationinresponsetoendoplasmicreticulumstressGCN2-mediatedsignalinglearninglong-termmemorynegativeregulationbyhostofviralgenomereplicationnegativeregulationofCREBtranscriptionfactoractivitynegativeregulationofneurondifferentiationnegativeregulationoftranslationalinitiationnegativeregulationoftranslationalinitiationinresponsetostressneuronprojectionextensionpositiveregulationofadaptiveimmuneresponsepositiveregulationofdefenseresponsetovirusbyhostpositiveregulationoflong-termsynapticpotentiationpositiveregulationofproteinphosphorylationpositiveregulationoftranslationalinitiationinresponsetostarvationproteinautophosphorylationproteinphosphorylationregulationoffeedingbehaviorregulationoftranslationalinitiationregulationoftranslationalinitiationbyeIF2alphaphosphorylationTcellactivationinvolvedinimmuneresponseviraltranslation
Tubulin alpha chain
8.9
61
45
D0VWZ0D0VWZ0D0VWZ0D0VWZ0microtubule-basedprocess
RNA helicase aquarius
7.0
nan
58
AQRAQRO60306O60306mRNAsplicingviaspliceosome
Phosducin-like protein 2
7.8
62
52
PDCL2PDCL2Q9DA99Q9DA99proteinfolding
Amine oxidase [flavin-containing] B
8.9
88
36
AOFBAOFBP27338P27338dopaminecatabolicprocesshydrogenperoxidebiosyntheticprocessnegativeregulationofserotoninsecretionneurotransmittercatabolicprocesspositiveregulationofdopaminemetabolicprocessresponsetoaluminumionresponsetocorticosteroneresponsetoethanolresponsetolipopolysaccharideresponsetoseleniumionresponsetotoxicsubstanceresponsetoxenobioticstimulussubstantianigradevelopment
17-beta-hydroxysteroid dehydrogenase type 1
7.7
95
33
DHB1DHB1P14061P14061bonedevelopmentcellularresponsetometalionestrogenbiosyntheticprocessestrogenmetabolicprocesssteroidbiosyntheticprocesstestosteronebiosyntheticprocess
Gem-associated protein 2
7.7
75
46
GEMI2GEMI2O14893O14893mRNAprocessingnegativeregulationofRNAbindingRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomalcomplexassemblyspliceosomalsnRNPassembly
D-ribitol-5-phosphate cytidylyltransferase
5.3
68
59
ISPDISPDA4D126A4D126axonguidanceisoprenoidbiosyntheticprocessproteinO-linkedmannosylation
RAR-related orphan receptor C isoform a variant
7.7
54
46
Q53FZ4Q53FZ4Q53FZ4Q53FZ4
Tyrosine-protein phosphatase non-receptor type 3
7.7
66
44
PTN3PTN3P26045P26045liverregenerationMAPKcascadenegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofmembraneproteinectodomainproteolysisnegativeregulationofmitoticcellcycleproteindephosphorylationregulationofmembranedepolarizationduringactionpotentialregulationofsodiumiontransmembranetransporteractivity
ARF GTPase-activating protein GIT1
7.8
75
45
GIT1GIT1Q68FF6Q68FF6braindevelopmentcellredoxhomeostasiscellularresponsetoepidermalgrowthfactorstimuluscellularresponsetolipopolysaccharidedendriticspinedevelopmentephrinreceptorsignalingpathwayimmunologicalsynapseformationintramembranousossificationlocomotorybehaviormotorlearningnegativeregulationofARFproteinsignaltransductionnegativeregulationofglycolyticprocessnegativeregulationofinflammatoryresponsetowoundingnegativeregulationofinterleukin-1betaproductionneurondevelopmentneurotransmitterreceptorlocalizationtopostsynapticspecializationmembranepositiveregulationofmicrotubulenucleationpositiveregulationofreceptorcatabolicprocesspresynapticmodulationofchemicalsynaptictransmissionregulationofARFproteinsignaltransductionregulationofcytokinesisregulationofGprotein-coupledreceptorsignalingpathwayregulationofsynapticvesicleexocytosissynapticvesiclerecycling
Gamma-enolase
7.7
94
35
ENOGENOGP09104P09104canonicalglycolysisgluconeogenesisglycolyticprocessmulticellularorganismalreproductiveprocessnegativeregulationofneurondeathresponsetoestradiolresponsetoxenobioticstimulus
Polyadenylate-binding protein-interacting protein 1
7.7
73
40
PAIP1PAIP1Q9H074Q9H074CRD-mediatedmRNAstabilizationmRNAstabilizationnegativeregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationbyhostofviralprocesspositiveregulationofcytoplasmictranslationregulationoftranslationalinitiationtranslationalinitiation
Unconventional myosin-Va
2.0
nan
88
MYO5AMYO5AQ99104Q99104actinfilamentorganizationactinfilament-basedmovementaxo-dendriticproteintransportcellularresponsetoinsulinstimuluschemicalsynaptictransmissiondevelopmentalpigmentationdopaminemetabolicprocessendoplasmicreticulumlocalizationestablishmentofendoplasmicreticulumlocalizationtopostsynapseexocytosishairfolliclematurationinsulinsecretionlocomotioninvolvedinlocomotorybehaviorlong-chainfattyacidbiosyntheticprocessmacroautophagymelaninbiosyntheticprocessmelaninmetabolicprocessmelanocytedifferentiationmelanosomelocalizationmelanosometransportmyelinationnegativeregulationofdopaminesecretionnegativeregulationofsynaptictransmissionglutamatergicodontogenesispigmentationpositiveregulationofcellularresponsetoinsulinstimuluspositiveregulationofcytochrome-coxidaseactivitypositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofvascularassociatedsmoothmusclecellmigrationpost-Golgivesicle-mediatedtransportproteinlocalizationtoplasmamembraneprotein-containingcomplexassemblyreactivegliosisregulationofexocytosisregulationofinositol145-trisphosphate-sensitivecalcium-releasechannelactivityregulationofpostsynapticcytosoliccalciumionconcentrationsecretorygranulelocalizationsynapseorganizationvesicletransportalongactinfilamentvesicle-mediatedtransportvisualperception
StAR-related lipid transfer protein 4
7.7
64
48
STAR4STAR4Q96DR4Q96DR4cholesterolimportcholesteroltransportinvolvedincholesterolstorageintracellularcholesteroltransportpositiveregulationofbileacidbiosyntheticprocesspositiveregulationofcholesterolmetabolicprocess
Histone acetyltransferase KAT2B
7.8
67
46
KAT2BKAT2BQ92831Q92831cellcyclecellularresponsetoinsulinstimuluschromatinremodelinggluconeogenesisheartdevelopmenthistoneacetylationhistoneH3acetylationhistoneH3-K14acetylationinternalpeptidyl-lysineacetylationlimbdevelopmentmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationN-terminalpeptidyl-lysineacetylationnegativeregulationofcellpopulationproliferationnegativeregulationofcentriolereplicationnegativeregulationofrRNAprocessingpeptidyl-lysineacetylationpositiveregulationofattachmentofmitoticspindlemicrotubulestokinetochorepositiveregulationofDNA-templatedtranscriptionpositiveregulationofgluconeogenesispositiveregulationoftranscriptionbyRNApolymeraseIIproteinacetylationregulationofcellcycleregulationofcelldivisionregulationofDNArepairregulationofDNA-templatedtranscriptionregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationofproteinADP-ribosylationregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylationrhythmicprocesstranscriptioninitiation-coupledchromatinremodeling
Tubulin alpha-1A chain
7.8
80
39
✔
TBA1ATBA1AP02550P02550microtubulecytoskeletonorganizationmitoticcellcycle
Tubulin beta chain
7.2
64
55
F2Z5B2F2Z5B2F2Z5B2F2Z5B2microtubule-basedprocess
Adenosine 5'-monophosphoramidase HINT1
7.8
69
44
✔
HINT1HINT1P49773P49773intrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofcalcium-mediatedsignalingproteindesumoylationpurineribonucleotidecatabolicprocessregulationofDNA-templatedtranscriptionsignaltransduction
Growth factor receptor-bound protein 7
7.8
63
48
GRB7GRB7Q14451Q14451epidermalgrowthfactorreceptorsignalingpathwaynegativeregulationoftranslationpositiveregulationofcellmigrationstressgranuleassembly
Glycogenin-1
7.8
91
37
GLYGGLYGP13280P13280glycogenbiosyntheticprocess
Tripartite motif-containing protein 2
7.8
76
41
TRIM2TRIM2Q9C040Q9C040proteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationregulationofneuronapoptoticprocess
Kinesin-like protein KIF18A
7.8
72
45
KI18AKI18AQ8NI77Q8NI77cellularresponsetoestradiolstimulusmalemeioticnucleardivisionmicrotubuledepolymerizationmicrotubule-basedmovementmitoticmetaphaseplatecongressionmitoticsisterchromatidsegregationproteintransportregulationofmicrotubulecytoskeletonorganizationseminiferoustubuledevelopment
Peptide deformylase, mitochondrial
7.8
44
57
DEFMDEFMQ9HBH1Q9HBH1co-translationalproteinmodificationN-terminalproteinaminoacidmodificationpeptidyl-methioninemodificationpositiveregulationofcellpopulationproliferationtranslation
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
7.8
92
40
A0A6P7E5N1A0A6P3TFB2A0A7M4DUG3A0A6P3TFB2
CASP8 and FADD-like apoptosis regulator
7.8
52
53
CFLARCFLARO15519O15519activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocesscellularresponsetodexamethasonestimuluscellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoestradiolstimuluscellularresponsetohypoxiacellularresponsetoinsulinstimuluscellularresponsetonitricoxidenegativeregulationofapoptoticprocessnegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofcellularresponsetotransforminggrowthfactorbetastimulusnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofmyoblastfusionnegativeregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofextracellularmatrixorganizationpositiveregulationofglomerularmesangialcellproliferationpositiveregulationofhepatocyteproliferationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivityproteolysisregulationofnecroptoticprocessregulationofskeletalmusclesatellitecellproliferationresponsetotestosteroneskeletalmuscleatrophyskeletalmuscletissuedevelopmentskeletalmuscletissueregenerationskeletalmyofibrilassemblywoundhealing
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
7.8
74
44
ACMSDACMSDQ8TDX5Q8TDX5negativeregulationofquinolinatebiosyntheticprocesspicolinicacidbiosyntheticprocess"regulationofdenovoNADbiosyntheticprocessfromtryptophan"secondarymetabolicprocesstryptophancatabolicprocess
6-phosphogluconate dehydrogenase, decarboxylating
7.8
84
42
✔
6PGD6PGDP00349P00349D-gluconatemetabolicprocesspentose-phosphateshunt
Thioredoxin reductase 3
7.8
49
60
TRXR3TRXR3Q86VQ6Q86VQ6celldifferentiationcellredoxhomeostasisspermatogenesis
Pyruvate kinase
7.8
75
41
Q16716Q16716Q16716Q16716
Importin subunit alpha
7.8
67
43
H0VVB1H0VVB1H0VVB1H0VVB1proteinimportintonucleus
Nuclear valosin-containing protein-like
7.8
50
54
✔
NVLNVLO15381O15381positiveregulationofproteinbindingpositiveregulationoftelomeraseactivityregulationofproteinlocalizationtonucleolusribosomallargesubunitbiogenesisribosomebiogenesisrRNAprocessing
FERM, ARHGEF and pleckstrin domain-containing protein 2
5.3
57
68
FARP2FARP2Q91VS8Q91VS8actincytoskeletonreorganizationcelladhesionhaircycleprocessneuronremodelingosteoclastdifferentiationpodosomeassemblyRacproteinsignaltransductionregulationofintegrinactivationsemaphorin-plexinsignalingpathway
Alpha-enolase
7.8
93
35
✔
ENOAENOAP06733P06733canonicalglycolysisglycolyticprocessnegativeregulationofcellgrowthnegativeregulationofDNA-templatedtranscriptionnegativeregulationofhypoxia-inducedintrinsicapoptoticsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofATPbiosyntheticprocesspositiveregulationofmusclecontractionpositiveregulationofplasminogenactivationresponsetovirus
39S ribosomal protein L21, mitochondrial isoform d
7.8
nan
59
F1RY70F1RY70F1RY70F1RY70translation
Septin-6
7.8
80
38
SEPT6SEPT6Q14141Q14141celldifferentiationciliumassemblycytoskeleton-dependentcytokinesismitoticcytokinesisspermatogenesis
Electron transfer flavoprotein subunit beta
7.8
80
43
ETFBETFBP38117P38117aminoacidcatabolicprocessfattyacidbeta-oxidationusingacyl-CoAdehydrogenaserespiratoryelectrontransportchain
Cytoplasmic tyrosine-protein kinase BMX
7.8
74
40
BMXBMXP51813P51813adaptiveimmuneresponseapoptoticprocessBcellreceptorsignalingpathwaycelladhesionintracellularsignaltransductionmesodermdevelopmentphosphatidylinositolbiosyntheticprocessproteinautophosphorylationproteinphosphorylationsignaltransduction
Ras-related protein Rab-21
7.8
83
40
RAB21RAB21Q9UL25Q9UL25anterogradeaxonaltransportintracellularproteintransportpositiveregulationofdendritemorphogenesispositiveregulationofearlyendosometolateendosometransportpositiveregulationofreceptor-mediatedendocytosisproteinstabilizationRabproteinsignaltransductionregulationofaxonextensionregulationofexocytosis
D-amino-acid oxidase
7.8
64
46
OXDAOXDAP14920P14920D-alaninecatabolicprocessD-aminoacidcatabolicprocessD-serinecatabolicprocessD-serinemetabolicprocessdopaminebiosyntheticprocessprolinecatabolicprocess
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
7.8
83
39
F264F264P25114P25114fructose26-bisphosphatemetabolicprocessfructosemetabolicprocess
Cordon-bleu protein-like 1
7.8
60
51
COBL1COBL1Q53SF7Q53SF7
Glutathione S-transferase Mu 3
7.8
nan
60
✔
GSTM3GSTM3P21266P21266cellulardetoxificationofnitrogencompoundestablishmentofblood-nervebarrierglutathionemetabolicprocessnitrobenzenemetabolicprocessresponsetoestrogenxenobioticcatabolicprocess
Serine incorporator 3
3.7
46
83
SERC3SERC3Q13530Q13530defenseresponsetovirusdetectionofvirusinnateimmuneresponseL-serinebiosyntheticprocesspositiveregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathway
Splicing factor 45
7.8
70
45
SPF45SPF45Q96I25Q96I25alternativemRNAsplicingviaspliceosomemRNAcissplicingviaspliceosomemRNAsplicingviaspliceosome
Plakophilin-1
8.3
60
48
PKP1PKP1Q13835Q13835celladhesioncell-celladhesioncell-celljunctionassemblyintermediatefilamentbundleassemblynegativeregulationofmRNAcatabolicprocesspositiveregulationofgeneexpressionsignaltransduction
Acyl-protein thioesterase 2
7.8
68
46
LYPA2LYPA2O95372O95372acylglycerolcatabolicprocessaxonguidancefattyacidmetabolicprocessprostaglandincatabolicprocessproteindepalmitoylation
Inorganic pyrophosphatase
7.8
35
60
✔
IPYRIPYRQ15181Q15181phosphate-containingcompoundmetabolicprocess
Thiamin pyrophosphokinase 1
8.1
74
48
TPK1TPK1Q9H3S4Q9H3S4phosphorylationthiaminediphosphatebiosyntheticprocessthiaminemetabolicprocess
Retinoic acid receptor RXR-beta
8.0
60
44
✔
RXRBRXRBP28702P28702anatomicalstructuredevelopmentcelldifferentiationhormone-mediatedsignalingpathwaymRNAtranscriptionbyRNApolymeraseIIpositiveregulationofbonemineralizationpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvitaminDreceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetoretinoicacidretinoicacidreceptorsignalingpathway
Crossover junction endonuclease MUS81
7.8
55
51
MUS81MUS81Q96NY9Q96NY9DNAcatabolicprocessendonucleolyticDNArepairdouble-strandbreakrepairdouble-strandbreakrepairviabreak-inducedreplicationmitoticintra-SDNAdamagecheckpointsignalingosteoblastproliferationreplicationforkprocessingresolutionofmeioticrecombinationintermediatesresponsetointra-SDNAdamagecheckpointsignaling
E3 ubiquitin-protein ligase TRIM11
7.8
83
39
TRI11TRI11Q96F44Q96F44innateimmuneresponsenegativeregulationofDNA-templatedtranscriptionnegativeregulationofneurogenesisnegativeregulationofviralentryintohostcellnegativeregulationofviraltranscriptionpositiveregulationofviralentryintohostcellproteinubiquitinationregulationofgeneexpressionsuppressionofviralreleasebyhost
PHD finger protein 19
7.8
72
50
PHF19PHF19Q5T6S3Q5T6S3chromatinorganizationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofhistoneH3-K27methylationregulationofDNA-templatedtranscriptionstemcelldifferentiationstemcellpopulationmaintenance
non-specific serine/threonine protein kinase
7.8
65
46
Q9UPJ8Q9UPJ8Q9UPJ8Q9UPJ8proteinphosphorylation
Inner nuclear membrane protein Man1
7.9
45
54
MAN1MAN1Q9Y2U8Q9Y2U8negativeregulationofactivinreceptorsignalingpathwaynegativeregulationofBMPsignalingpathwaynegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynuclearenvelopeorganization
40S ribosomal protein S3a
7.9
73
44
G1SS70G1SS70G1SS70G1SS70celldifferentiationtranslation
Dual specificity protein phosphatase 15
7.9
67
39
DUS15DUS15Q5QP65Q5QP65dephosphorylationproteindephosphorylationregulationofoligodendrocytedifferentiationsignaltransduction
39S ribosomal protein S30, mitochondrial
7.9
71
46
✔
RT30RT30Q9NP92Q9NP92apoptoticprocessmitochondrialtranslation
Nitric oxide-associated protein 1
6.4
nan
70
NOA1NOA1Q8NC60Q8NC60apoptoticprocessmitochondrialtranslationregulationofcelldeathregulationofcellularrespiration
Beta/gamma crystallin domain-containing protein 1
7.9
70
48
CRBG1CRBG1Q9Y4K1Q9Y4K1
Tetratricopeptide repeat protein 7B
7.9
73
44
TTC7BTTC7BQ86TV6Q86TV6phosphatidylinositolphosphatebiosyntheticprocessproteinlocalizationtoplasmamembrane
Translation initiation factor eIF-2B subunit beta
3.6
67
86
EI2BBEI2BDP49770Q9UI10centralnervoussystemdevelopmentmyelinationoligodendrocytedevelopmentovarianfollicledevelopmentregulationoftranslationalinitiationresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiationregulationoftranslation
39S ribosomal protein L46, mitochondrial
7.9
89
37
RM46RM46Q9H2W6Q9H2W6mitochondrialtranslation
Transmembrane protein 120B
6.5
48
65
T120BT120BA0PK00A0PK00fatcelldifferentiationproteinheterooligomerization
Septin-11
7.9
82
36
SEP11SEP11Q9NVA2Q9NVA2cytoskeleton-dependentcytokinesis
Fas apoptotic inhibitory molecule 1
7.9
57
50
FAIM1FAIM1Q9NVQ4Q9NVQ4apoptoticprocessI-kappaBkinase/NF-kappaBsignalingnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofneurogenesis
Large neutral amino acids transporter small subunit 2
2.0
48
87
4F2LAT2J3KPF3Q9UHI5aminoacidtransportcalciumiontransportcarbohydratemetabolicprocessisoleucinetransportL-alanineimportacrossplasmamembraneL-histidinetransportL-leucineimportacrossplasmamembraneleucineimportacrossplasmamembraneleucinetransportmethioninetransportphenylalaninetransportprolinetransportresponsetoexogenousdsRNAthyroidhormonetransporttryptophantransporttyrosinetransportvalinetransportviralentryintohostcellaminoacidimportacrossplasmamembraneglycinetransportmetalionhomeostasisneutralaminoacidtransportprolinetransmembranetransportresponsetotoxicsubstancetransportacrossblood-brainbarrier
Methylenetetrahydrofolate reductase (NADPH)
8.4
68
47
MTHRMTHRP42898P42898heterochromatinorganizationhomocysteinemetabolicprocessmethioninebiosyntheticprocessmethioninemetabolicprocessneuraltubeclosureregulationofhistonemethylationresponsetoaminoacidresponsetofolicacidresponsetohypoxiaresponsetointerleukin-1responsetovitaminB2responsetoxenobioticstimulusS-adenosylmethioninemetabolicprocesstetrahydrofolateinterconversion
E3 ubiquitin-protein ligase RNF13
8.8
62
59
RNF13RNF13O43567O43567organellelocalizationpositiveregulationofstress-activatedproteinkinasesignalingcascadeproteinautoubiquitinationubiquitin-dependentproteincatabolicprocess
Na(+)/citrate cotransporter
8.3
59
45
S13A5S13A5Q86YT5Q86YT5alpha-ketoglutaratetransportaniontransmembranetransportcellularresponsetolithiumioncitratetransportfumaratetransportoxaloacetatetransportsuccinatetransport
Fanconi anemia group E protein
7.9
63
48
FANCEFANCEQ9HB96Q9HB96interstrandcross-linkrepairproteinmonoubiquitination
Hepatocyte nuclear factor 6
7.9
43
54
HNF6HNF6O08755O08755anatomicalstructuremorphogenesisBcelldifferentiationcellfatecommitmentcellmigrationciliumassemblyendocrinepancreasdevelopmentendodermdevelopmententeroendocrinecelldifferentiationepithelialcelldevelopmentglucosemetabolicprocessliverdevelopmentnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayNotchsignalingpathwaypancreasdevelopmentpancreaticAcelldifferentiationpancreaticDcelldifferentiationpositiveregulationofcellmigrationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcell-matrixadhesionregulationoftranscriptionbyRNApolymeraseIIspleendevelopmenttransforminggrowthfactorbetareceptorsignalingpathwaytypeBpancreaticcelldifferentiation
[tau protein] kinase
7.9
76
39
Q6FI27Q6FI27Q6FI27Q6FI27glycogenmetabolicprocessnegativeregulationofdevelopmentalprocessnegativeregulationofsignaltransductionproteinphosphorylationregulationofcellularcomponentorganizationrhythmicprocessWntsignalingpathway
Rhodopsin
4.5
32
81
OPSDOPSDP02699P02699absorptionofvisiblelightcellularresponsetolightstimulusdetectionoftemperaturestimulusinvolvedinthermoceptionGprotein-coupledreceptorsignalingpathwayphotoreceptorcellmaintenancephototransductionphototransductionvisiblelightproteinphosphorylationresponsetolightstimulusretinadevelopmentincamera-typeeyerhodopsinmediatedsignalingpathwaythermotaxisvisualperception
B-cell lymphoma 3 protein
7.9
67
49
BCL3BCL3P20749P20749antimicrobialhumoralresponsecellularresponsetoDNAdamagestimulusdefenseresponsetobacteriumdefenseresponsetoprotozoanDNAdamageresponsesignaltransductionbyp53classmediatorextracellularmatrixorganizationfolliculardendriticcelldifferentiationgerminalcenterformationhumoralimmuneresponsemediatedbycirculatingimmunoglobulinI-kappaBkinase/NF-kappaBsignalingintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatormarginalzoneBcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofDNA-templatedtranscriptionnegativeregulationofinterleukin-8productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofTcellapoptoticprocessnegativeregulationoftumornecrosisfactorproductionpositiveregulationofDNA-templatedtranscriptionpositiveregulationofinterleukin-10productionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationpositiveregulationoftypeIIinterferonproductionproteinimportintonucleusregulationofapoptoticprocessregulationofDNAbindingregulationofNIK/NF-kappaBsignalingresponsetoUV-CresponsetovirusspleendevelopmentTcellapoptoticprocessT-helper1typeimmuneresponseT-helper2celldifferentiation
H/ACA ribonucleoprotein complex subunit DKC1
9.7
50
41
✔
DKC1DKC1O60832O60832"boxH/ACARNA3-endprocessing"enzyme-directedrRNApseudouridinesynthesismRNApseudouridinesynthesispositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationoftelomeraseactivitypositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceviatelomeraseregulationoftelomeraseRNAlocalizationtoCajalbodyRNAprocessingrRNAprocessingrRNApseudouridinesynthesisscaRNAlocalizationtoCajalbodysnRNApseudouridinesynthesistelomeraseRNAstabilizationtelomeremaintenanceviatelomerase
Alanine aminotransferase 2
7.9
52
55
ALAT2ALAT2Q8TD30Q8TD302-oxoglutaratemetabolicprocessbiosyntheticprocessL-alaninecatabolicprocessL-alaninemetabolicprocess
GTP-binding protein SAR1b
7.9
78
36
✔
SAR1BSAR1BQ9Y6B6Q9Y6B6antigenprocessingandpresentationofpeptideantigenviaMHCclassIendoplasmicreticulumtoGolgivesicle-mediatedtransportintracellularproteintransportlipidhomeostasislipoproteintransportmembraneorganizationpositiveregulationofproteinexitfromendoplasmicreticulumregulationofCOPIIvesiclecoatingregulationoflipidtransportvesicleorganization
Guanine nucleotide-binding protein G(t) subunit alpha-1
7.9
70
43
GNAT1GNAT1P04695P04695adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellpopulationproliferationcellularresponsetoelectricalstimulusdetectionoflightstimulusinvolvedinvisualperceptioneyephotoreceptorcelldevelopmentGprotein-coupledadenosinereceptorsignalingpathwaynegativeregulationofcyclic-nucleotidephosphodiesteraseactivityphototransductionphototransductionvisiblelightresponsetolightstimulusretinadevelopmentincamera-typeeyesensoryperceptionofumamitaste
Monoacylglycerol lipase ABHD6
7.9
86
36
ABHD6ABHD6Q9BV23Q9BV23acylglycerolcatabolicprocessarachidonicacidmetabolicprocesslong-termsynapticdepressionlysobisphosphatidicacidmetabolicprocessmonoacylglycerolcatabolicprocessnegativeregulationofcellmigrationnegativeregulationofcold-inducedthermogenesisphospholipidcatabolicprocesspositiveregulationoflipidbiosyntheticprocessregulationofendocannabinoidsignalingpathwayregulationofretrogradetrans-synapticsignalingbyendocanabinoid
Mediator of RNA polymerase II transcription subunit 17
7.9
62
47
✔
MED17MED28Q9NVC6Q9H204positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblysomaticstemcellpopulationmaintenancetranscriptioninitiationatRNApolymeraseIIpromoternegativeregulationofsmoothmusclecelldifferentiation
Nuclear pore complex protein Nup133
7.9
75
37
NU133NU133Q8WUM0Q8WUM0mRNAexportfromnucleusnephrondevelopmentneuraltubedevelopmentneurogenesisnuclearporeorganizationnucleocytoplasmictransportparaxialmesodermdevelopmentpoly(A)+mRNAexportfromnucleusproteinimportintonucleussomitedevelopmenttranscription-dependenttetheringofRNApolymeraseIIgeneDNAatnuclearperiphery
EH domain-containing protein 4
7.9
69
42
EHD4EHD4Q9EQP2Q9EQP2cellularresponsetogrowthfactorstimulusciliumassemblyendocyticrecyclingendocytosisendosomaltransportpinocytosispositiveregulationofpeptidyl-tyrosinephosphorylationproteinhomooligomerizationproteinlocalizationtoplasmamembraneregulationofendocytosis
Serine/threonine-protein kinase 38
8.0
76
42
STK38STK38Q15208Q15208intracellularsignaltransductionnegativeregulationofMAPkinaseactivitypeptidyl-serinephosphorylationpostsynapseorganizationproteinmodificationprocessproteinphosphorylation
Protein S100-A4
9.9
57
37
S10A4S10A4P26447P26447epithelialtomesenchymaltransitionpositiveregulationofI-kappaBkinase/NF-kappaBsignaling
Squalene monooxygenase
8.0
64
38
ERG1ERG1Q14534Q14534cellulararomaticcompoundmetabolicprocesscholesterolmetabolicprocesslipiddropletformationregulationofcellpopulationproliferationresponsetoorganicsubstancesterolbiosyntheticprocess
Proto-oncogene tyrosine-protein kinase ROS
9.2
69
37
ROS1ROS1P08922P08922celldifferentiationcolumnar/cuboidalepithelialcelldevelopmentpositiveregulationofkinaseactivityproteinphosphorylationregulationofcellgrowthregulationofERK1andERK2cascaderegulationofTORsignalingspermatogenesistransmembranereceptorproteintyrosinekinasesignalingpathway
Ras-related protein Rab-30
8.0
49
52
✔
RAB30RAB30Q15771Q15771GolgiorganizationRabproteinsignaltransductionvesicle-mediatedtransport
Actin-like protein 6A
8.0
61
49
✔
ACL6AACL6AO96019O96019blastocystformationchromatinremodelingDNArecombinationDNArepairhistoneacetylationhistoneH2AacetylationhistoneH4acetylationnegativeregulationofcelldifferentiationnervoussystemdevelopmentneuralretinadevelopmentpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationpositiveregulationoftelomeremaintenanceinresponsetoDNAdamageregulationofapoptoticprocessregulationofcellcycleregulationofchromosomeorganizationregulationofDNArepairregulationofDNAreplicationregulationofDNAstrandelongationregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepairregulationofembryonicdevelopmentregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIIsignaltransductionspinalcorddevelopmenttelomeremaintenance
Septin-8
8.0
83
35
SEPT8SEPT8Q92599Q92599cytoskeleton-dependentcytokinesisregulationofintracellularproteintransportregulationofproteinstabilityregulationofSNAREcomplexassembly
Replication factor C subunit 5
8.0
78
37
✔
RFC5RFC5P40937P40937DNAduplexunwindingDNArepairDNAreplicationDNA-templatedDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivity
Ras-related protein Rab-8A
8.0
84
35
RAB8ARAB8AP61006P61006autophagyaxonogenesiscellularresponsetoinsulinstimulusciliumassemblyendocyticrecyclingGolgiorganizationGolgivesiclefusiontotargetmembraneneurotransmitterreceptortransporttopostsynapticmembraneneurotransmitterreceptortransportendosometopostsynapticmembraneproteinlocalizationtociliumproteinlocalizationtoplasmamembraneproteinsecretionregulationofautophagyregulationofexocytosisregulationoflong-termneuronalsynapticplasticityregulationofproteintransportvesicledockinginvolvedinexocytosisvesicle-mediatedtransportinsynapse
Signal transducer and activator of transcription 1-alpha/beta
8.0
72
39
STAT1STAT1P42224P42224bloodcirculationcellularresponsetoinsulinstimuluscellularresponsetointerferon-betacellularresponsetoorganiccycliccompoundcellularresponsetotypeIIinterferoncytokine-mediatedsignalingpathwaydefenseresponsedefenseresponsetovirusinterleukin-27-mediatedsignalingpathwaymacrophagederivedfoamcelldifferentiationmetanephricmesenchymalcelldifferentiationmetanephricmesenchymalcellproliferationinvolvedinmetanephrosdevelopmentnegativeregulationbyvirusofviralproteinlevelsinhostcellnegativeregulationofangiogenesisnegativeregulationofendothelialcellproliferationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofmetanephricnephrontubuleepithelialcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-templatedtranscriptionpositiveregulationoferythrocytedifferentiationpositiveregulationofinterferon-alphaproductionpositiveregulationofmesenchymalcellproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofsmoothmusclecellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIreceptorsignalingpathwayviaJAK-STATregulationofapoptoticprocessregulationofcellpopulationproliferationrenaltubuledevelopmentresponsetocAMPresponsetocytokineresponsetohydrogenperoxideresponsetointerferon-betaresponsetomechanicalstimulusresponsetonutrientresponsetopeptidehormoneresponsetotypeIIinterferonresponsetoxenobioticstimulustumornecrosisfactor-mediatedsignalingpathwaytypeIinterferon-mediatedsignalingpathwaytypeIIinterferon-mediatedsignalingpathway
THUMP domain-containing protein 1
8.0
53
52
THUM1THUM1Q9NXG2Q9NXG2tRNAmodification
DNA-directed RNA polymerase II subunit RPB4
8.0
66
42
RPB4RPB4O15514O15514mRNAexportfromnucleusinresponsetoheatstressnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationoftranslationalinitiation"recruitmentof3-endprocessingfactorstoRNApolymeraseIIholoenzymecomplex"transcriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoter
Sperm-associated antigen 1
8.0
64
45
SPAG1SPAG1Q07617Q07617axonemaldyneincomplexassemblyproteinstabilizationsinglefertilization
b(0,+)-type amino acid transporter 1
3.8
51
80
SLC31BAT1Q07837P82251aminoacidtransportaspartatetransmembranetransportbasicaminoacidtransportcarbohydratemetabolicprocessgeneexpressionL-cystinetransportL-glutamatetransmembranetransportneutralaminoacidtransportprotein-containingcomplexassembly
Pseudouridine-5'-phosphatase
8.0
82
40
HDHD1HDHD1Q08623Q08623nucleotidemetabolicprocess
CCR4-NOT transcription complex subunit 7
9.8
47
40
CNOT7CNOT7Q9UIV1Q9UIV1deadenylation-dependentdecappingofnuclear-transcribedmRNAdefenseresponsetovirusexonucleolyticcatabolismofdeadenylatedmRNAmiRNA-mediatedgenesilencingnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationoftypeIinterferon-mediatedsignalingpathwaynuclear-transcribedmRNApoly(A)tailshorteningP-bodyassemblypositiveregulationofcellpopulationproliferationpositiveregulationofmRNAcatabolicprocesspositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofviralgenomereplicationregulationoftyrosinephosphorylationofSTATproteinRNA-mediatedgenesilencing
Selenide, water dikinase 1
8.1
92
38
SPS1SPS1P49903P49903phosphorylationproteinmodificationprocessselenocysteinebiosyntheticprocess
Poly(A) RNA polymerase, mitochondrial
7.5
71
45
PAPD1PAPD1Q9NVV4Q9NVV4histonemRNAcatabolicprocessmRNApolyadenylation"RNA3-endprocessing"
Ubiquitin-like modifier-activating enzyme 1
9.0
51
45
✔
UBA1UBA1Q02053Q02053cellularresponsetoDNAdamagestimulusproteinmodificationbysmallproteinconjugationproteinubiquitinationubiquitin-dependentproteincatabolicprocess
Palladin
4.9
69
67
PALLDPALLDQ9ET54Q9ET54actincytoskeletonorganizationcellmigrationepithelialcellmorphogenesishomophiliccelladhesionviaplasmamembraneadhesionmoleculeskeratinocytedevelopmentsynapseorganization
Origin recognition complex subunit 4
8.1
66
47
ORC4ORC4O43929O43929DNAreplicationinitiationpolarbodyextrusionaftermeioticdivisionsproteinpolymerization
Serine hydroxymethyltransferase, cytosolic
7.8
nan
54
✔
HA11GLYCP01899P09991antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-dependentantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbnegativeregulationofneuronprojectiondevelopmentpositiveregulationofTcellmediatedcytotoxicityTcellmediatedcytotoxicityfusionofvirusmembranewithhostendosomemembranereceptor-mediatedendocytosisofvirusbyhostcellvirionattachmenttohostcell
E3 ubiquitin-protein ligase TRIM7
8.1
73
41
TRIM7TRIM7Q9C029Q9C029proteinubiquitination
Adenylosuccinate synthetase isozyme 2
9.2
79
35
PURA2PURA2P30520P30520"denovoAMPbiosyntheticprocess"AMPbiosyntheticprocessaspartatemetabolicprocesscellularresponsetoelectricalstimulusimmunesystemprocessIMPmetabolicprocessresponsetoammoniumionresponsetopurine-containingcompound
CTD small phosphatase-like protein
8.1
76
45
CTDSLCTDSLO15194O15194negativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofproteinphosphorylation
Ribonuclease P protein subunit p38
8.6
55
46
RPP38RPP38P78345P78345rRNAprocessing"tRNA5-leaderremoval"
Mitochondrial amidoxime-reducing component 1
8.1
63
45
MARC1MARC1Q5VT66Q5VT66cellulardetoxificationofnitrogencompounddetoxificationofnitrogencompoundnitratemetabolicprocessnitricoxidebiosyntheticprocess
Guided entry of tail-anchored proteins factor 1
8.5
54
48
GET1CAMLGO00258P49069proteininsertionintoERmembraneproteinstabilizationtail-anchoredmembraneproteininsertionintoERmembraneBcellhomeostasisdefenseresponseepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationreceptorrecyclingsignaltransductionvesicle-mediatedtransport
Transcription factor E2F5
8.1
53
48
E2F5E2F5Q15329Q15329cellprojectionorganizationregulationoftranscriptionbyRNApolymeraseII
2'-5'-oligoadenylate synthase 1
4.2
78
70
OAS1OAS1Q29599Q29599defenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationregulationofribonucleaseactivity
Tyrosine-protein kinase
8.1
82
37
Q7TMU1Q7TMU1Q7TMU1Q7TMU1adaptiveimmuneresponseintracellularsignaltransduction
39S ribosomal protein L22, mitochondrial
8.1
50
50
E7ESL0E7ESL0E7ESL0E7ESL0translation
Tubulin alpha-1C chain
9.1
61
42
TBA1CTBA1CQ3ZCJ7Q3ZCJ7microtubulecytoskeletonorganizationmitoticcellcycle
Cytochrome c oxidase subunit 7C, mitochondrial
8.1
66
51
COX7CCOX8AP15954P10176cellularrespirationgenerationofprecursormetabolitesandenergymitochondrialelectrontransportcytochromectooxygen
Transforming growth factor beta regulator 1
8.7
42
48
TBRG1TBRG1Q3YBR2Q3YBR2cellcycleDNAreplicationnegativeregulationofcellpopulationproliferationproteinlocalizationtonucleoplasmproteinstabilizationregulationofcellcycle
28S ribosomal protein S35, mitochondrial isoform 1
8.1
73
47
F1SG95F1SG95F1SG95F1SG95mitochondrialtranslation
RuvB-like 1
8.1
57
45
RUVB1ARP6Q9Y265Q9GZN1boxC/DsnoRNPassemblycellcyclecelldivisionchromatinremodelingDNArecombinationDNArepairhistoneacetylationhistoneH2AacetylationhistoneH4acetylationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceinresponsetoDNAdamageproteinstabilizationregulationofapoptoticprocessregulationofcellcycleregulationofchromosomeorganizationregulationofDNArepairregulationofDNAreplicationregulationofDNAstrandelongationregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepairregulationofembryonicdevelopmentregulationoftranscriptionbyRNApolymeraseIIspermatogenesistelomeremaintenancenegativeregulationoftranscriptionbyRNApolymeraseInucleolusorganizationpositiveregulationoftranscriptionbyRNApolymeraseI
Protein Hook homolog 3
8.1
76
44
HOOK3HOOK3Q86VS8Q86VS8cytoplasmicmicrotubuleorganizationcytoskeleton-dependentintracellulartransportearlyendosometolateendosometransportendosomeorganizationendosometolysosometransportGolgilocalizationinterkineticnuclearmigrationlysosomeorganizationmicrotubuleanchoringatcentrosomenegativeregulationofneurogenesisneuronalstemcellpopulationmaintenanceproteinlocalizationtocentrosomeproteinlocalizationtoperinuclearregionofcytoplasmproteintransport
Axin-1
8.1
74
39
AXIN1APCO15169P25054activationofproteinkinaseactivityapoptoticprocessaxialmesodermformationcanonicalWntsignalingpathwaycelldevelopmentcytoplasmicmicrotubuleorganizationdorsal/ventralaxisspecificationgenomicimprintingheaddevelopmentinuteroembryonicdevelopmentnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationoffatcelldifferentiationnegativeregulationofproteinmetabolicprocessnegativeregulationoftranscriptionelongationbyRNApolymeraseIInucleocytoplasmictransportpositiveregulationofDNA-templatedtranscriptionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteincatabolicprocesspositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofubiquitin-dependentproteincatabolicprocesspositiveregulationofubiquitin-proteintransferaseactivitypost-analtailmorphogenesisproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationprotein-containingcomplexassemblysensoryperceptionofsoundbicellulartightjunctionassemblycelladhesioncellfatespecificationcellmigrationcellularresponsetoDNAdamagestimulusendocardialcushionmorphogenesisheartvalvedevelopmentinsulinreceptorsignalingpathwaymitoticcytokinesismitoticspindleassemblycheckpointsignalingnegativeregulationofcellcycleG1/Sphasetransitionnegativeregulationofcellpopulationproliferationnegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofmicrotubuledepolymerizationnervoussystemdevelopmentpatternspecificationprocesspositiveregulationofapoptoticprocesspositiveregulationofcelldeathpositiveregulationofcellmigrationpositiveregulationofcold-inducedthermogenesispositiveregulationofproteinlocalizationtocentrosomepositiveregulationofpseudopodiumassemblyregulationofattachmentofspindlemicrotubulestokinetochoreregulationofcelldifferentiationregulationofmicrotubule-basedprocessWntsignalingpathway
Urea transporter 1
6.9
79
47
UT1UT1Q5QF96Q5QF96establishmentoflocalizationincellureatransmembranetransport
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
8.2
84
34
CTDS1CTDS1Q9GZU7Q9GZU7negativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofneurogenesisnegativeregulationofneurondifferentiationnegativeregulationofproteinphosphorylationproteindephosphorylationregulationoftranscriptionbyRNApolymeraseII
Cytosolic purine 5'-nucleotidase
8.2
68
46
✔
5NTC5NTCP49902P49902adenosinemetabolicprocessallantoinmetabolicprocessdGMPmetabolicprocessGMPmetabolicprocessIMPcatabolicprocessIMPmetabolicprocessnucleotidephosphorylation
DCN1-like protein 1
8.2
53
44
✔
DCNL1DCNL1Q96GG9Q96GG9positiveregulationofproteinneddylationpositiveregulationofubiquitin-proteintransferaseactivityproteinneddylationregulationofproteinneddylationregulationofproteinubiquitination
Axin interactor, dorsalization-associated protein
8.2
67
43
AIDAAIDAQ8C4Q6Q8C4Q6determinationofventralidentitydorsal/ventralpatternformationnegativeregulationofdeterminationofdorsalidentitynegativeregulationofJNKcascadenegativeregulationofJUNkinaseactivitynegativeregulationofprotein-containingcomplexassemblyregulationofprotein-containingcomplexassembly
2-Hydroxyacid oxidase 1
8.2
92
36
HAOX1HAOX1Q9UJM8Q9UJM8fattyacidalpha-oxidationglycinebiosyntheticprocessglycolatecatabolicprocessresponsetooxidativestress
E3 ubiquitin-protein ligase HECW2
8.2
57
49
HECW2HECW2Q9P2P5Q9P2P5negativeregulationofsodiumiontransmembranetransporteractivityproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationregulationofdendritemorphogenesisregulationofmitoticmetaphase/anaphasetransition
Ankyrin-2
8.2
78
40
ANK2ANK2Q01484Q01484atrialcardiacmusclecellactionpotentialatrialcardiacmusclecelltoAVnodecellcommunicationatrialseptumdevelopmentcellularcalciumionhomeostasisendocytosismembranedepolarizationduringSAnodecellactionpotentialparanodaljunctionassemblypositiveregulationofcalciumiontransmembranetransporteractivitypositiveregulationofcalciumiontransportpositiveregulationofcationchannelactivitypositiveregulationofgeneexpressionpositiveregulationofpotassiumiontransmembranetransporteractivitypositiveregulationofpotassiumiontransportproteinlocalizationproteinlocalizationtocellsurfaceproteinlocalizationtoendoplasmicreticulumproteinlocalizationtoM-bandproteinlocalizationtoorganelleproteinlocalizationtoplasmamembraneproteinlocalizationtoT-tubuleproteinstabilizationproteintransportregulationofatrialcardiacmusclecellactionpotentialregulationofcalciumiontransmembranetransporteractivityregulationofcalciumiontransportregulationofcardiacmusclecellcontractionregulationofcardiacmusclecontractionregulationofcardiacmusclecontractionbycalciumionsignalingregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofheartrateregulationofheartratebycardiacconductionregulationofproteinstabilityregulationofreleaseofsequesteredcalciumionintocytosolregulationofSAnodecellactionpotentialregulationofventricularcardiacmusclecellmembranerepolarizationresponsetomethylmercurySAnodecellactionpotentialSAnodecelltoatrialcardiacmusclecellcommunicationsarcoplasmicreticulumcalciumiontransportT-tubuleorganizationventricularcardiacmusclecellactionpotential
TRIM15
8.2
77
45
A0A0G2JJP1A0A0G2JJP1A0A0G2JJP1A0A0G2JJP1
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
6.2
83
49
DHDHDHDHQ9TQS6Q9TQS6
Ubiquitin carboxyl-terminal hydrolase isozyme L5
8.2
71
46
UCHL5UCHL5Q9Y5K5Q9Y5K5chromatinremodelingDNArecombinationDNArepairforebrainmorphogenesislateralventricledevelopmentmidbraindevelopmentnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionpositiveregulationofsmoothenedsignalingpathwaypositiveregulationoftelomeremaintenanceinresponsetoDNAdamageproteindeubiquitinationregulationofcellcycleregulationofchromosomeorganizationregulationofDNArepairregulationofDNAreplicationregulationofDNAstrandelongationregulationofembryonicdevelopmentregulationofproteasomalproteincatabolicprocesstelomeremaintenanceubiquitin-dependentproteincatabolicprocess
Protein S100-B
8.2
59
39
S100BS100BP04271P04271axonogenesiscentralnervoussystemdevelopmentlearningormemorymemorypositiveregulationofcellpopulationproliferationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingregulationofneuronalsynapticplasticity
Galactose-1-phosphate uridylyltransferase
8.2
76
43
GALTGALTP07902P07902galactosecatabolicprocessgalactosecatabolicprocessviaUDP-galactosegalactosemetabolicprocessUDP-glucosecatabolicprocessUDP-glucosemetabolicprocess
Polyribonucleotide nucleotidyltransferase 1, mitochondrial
8.2
92
42
PNPT1PNPT1Q8TCS8Q8TCS8cellularresponsetointerferon-betacellularresponsetooxidativestressliverregenerationmitochondrialmRNAcatabolicprocessmitochondrialmRNApolyadenylation"mitochondrialRNA3-endprocessing""mitochondrialRNA5-endprocessing"mitochondrialRNAcatabolicprocessmitochondrionmorphogenesismRNAcatabolicprocessnegativeregulationofgrowthnuclearpolyadenylation-dependentmRNAcatabolicprocesspositiveregulationofmiRNAcatabolicprocesspositiveregulationofmitochondrialRNAcatabolicprocesspositiveregulationofmRNAcatabolicprocessproteinhomooligomerizationproteinhomotrimerizationregulationofcellcycleregulationofcellularrespirationregulationofcellularsenescenceresponsetocAMPresponsetogrowthhormoneRNAcatabolicprocessRNAimportintomitochondrionRNApolyadenylationrRNAimportintomitochondrion
Leucine-rich repeat protein SHOC-2
8.2
66
49
SHOC2SHOC2Q9UQ13Q9UQ13fibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofRasproteinsignaltransductionRasproteinsignaltransductionsignaltransduction
Transcriptional adapter 2-alpha
8.2
55
52
TAD2ATAD2AO75478O75478chromatinremodelinghistoneacetylationhistoneH3acetylationhistoneH3-K14acetylationpositiveregulationofhistoneacetylationregulationofcellcycleregulationofcelldivisionregulationofDNA-templatedtranscriptionregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylation
Methyltransferase like 27
8.2
81
40
Q8BGM4Q8BGM4Q8BGM4Q8BGM4
Tubulin beta chain
8.9
47
47
A0A287AGU7A0A287AGU7A0A287AGU7A0A287AGU7microtubule-basedprocess
D-aminoacyl-tRNA deacylase 1
8.2
92
41
DTD1DTD1Q8TEA8Q8TEA8DNAduplexunwindingDNAreplicationtRNAmetabolicprocess
EEF1A lysine methyltransferase 3
8.2
63
48
EFMT3EFMT3Q96AZ1Q96AZ1peptidyl-lysinemethylation
Glycolipid transfer protein
8.2
54
49
GLTPGLTPQ9NZD2Q9NZD2ceramidetransportglycosphingolipidmetabolicprocessintermembranelipidtransfer
Kelch-like protein 12
8.2
99
33
KLH12KLH12Q53G59Q53G59COPIIvesiclecoatingendoplasmicreticulumtoGolgivesicle-mediatedtransportneuralcrestcelldevelopmentneuralcrestformationproteinmonoubiquitinationWntsignalingpathway
Eukaryotic translation initiation factor 1A, X-chromosomal
8.2
73
48
IF1AXIF1AXP47813P47813translationalinitiation
CX3CL1 protein
2.0
nan
91
Q6I9S9Q6I9S9Q6I9S9Q6I9S9immuneresponse
Glycogen synthase kinase-3 beta
8.2
81
36
GSK3BGSK3BQ9WV60Q9WV60animalorganmorphogenesisaxonextensionaxonogenesisbeta-catenindestructioncomplexdisassemblyboneremodelingcanonicalWntsignalingpathwaycellgrowthinvolvedincardiacmusclecelldevelopmentcellmigrationcellularresponsetoamyloid-betacellularresponsetoglucocorticoidstimuluscellularresponsetohepatocytegrowthfactorstimuluscellularresponsetointerleukin-3cellularresponsetomechanicalstimuluscellularresponsetoretinoicacidcircadianrhythmcytoskeletonorganizationepithelialtomesenchymaltransitionERoverloadresponseestablishmentofcellpolarityestablishmentormaintenanceofcellpolarityextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayinabsenceofligandfatcelldifferentiationglycogenmetabolicprocesshepaticstellatecellactivationhepatocyteapoptoticprocesshippocampusdevelopmenthypermethylationofCpGislandinsulinreceptorsignalingpathwayintracellularsignaltransductionintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstressmaintenanceofcellpolaritymyoblastfusionmyotubedifferentiationnegativeregulationofapoptoticprocessnegativeregulationofcalcineurin-NFATsignalingcascadenegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwayinvolvedinosteoblastdifferentiationnegativeregulationofcardiacmusclehypertrophynegativeregulationofdendritedevelopmentnegativeregulationofdendritemorphogenesisnegativeregulationofdopaminergicneurondifferentiationnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationofgeneexpressionnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofmesenchymalstemcelldifferentiationnegativeregulationofneurondeathnegativeregulationofneuronmaturationnegativeregulationofneuronmigrationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofnitric-oxidesynthaseactivitynegativeregulationofproteinacetylationnegativeregulationofproteinbindingnegativeregulationofproteinlocalizationtocentrosomenegativeregulationofproteinlocalizationtonucleusnegativeregulationofprotein-containingcomplexassemblynegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationofsynapticassemblyatneuromuscularjunctionnegativeregulationofTORsignalingneuronprojectiondevelopmentneuronprojectionorganizationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationphosphorylationpositiveregulationofapoptoticprocesspositiveregulationofautophagypositiveregulationofaxonextensionpositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcelldifferentiationpositiveregulationofcell-matrixadhesionpositiveregulationofciliumassemblypositiveregulationofDNAbiosyntheticprocesspositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofmitochondrialmembranepotentialpositiveregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwaypositiveregulationofmitochondrionorganizationpositiveregulationofneuronapoptoticprocesspositiveregulationofneurondeathpositiveregulationofosteoblastproliferationpositiveregulationofosteoclastdifferentiationpositiveregulationofosteoclastproliferationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinbindingpositiveregulationofproteincatabolicprocesspositiveregulationofproteinexportfromnucleuspositiveregulationofproteinlocalizationtocentrosomepositiveregulationofproteinlocalizationtociliumpositiveregulationofprotein-containingcomplexassemblypositiveregulationofsmoothmusclecellproliferationpositiveregulationofstemcelldifferentiationpositiveregulationofsynapticassemblyatneuromuscularjunctionpositiveregulationoftranscriptionbyRNApolymeraseIIpresynapticmodulationofchemicalsynaptictransmissionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautophosphorylationproteinexportfromnucleusproteinlocalizationtomicrotubuleproteinphosphorylationre-entryintomitoticcellcycleregulationofapoptoticprocessregulationofaxonextensionregulationofaxonogenesisregulationofcellgrowthregulationofcircadianrhythmregulationofdendritemorphogenesisregulationofgeneexpressionbygenomicimprintingregulationoflong-termsynapticpotentiationregulationofmicrotubuleanchoringatcentrosomeregulationofmicrotubulecytoskeletonorganizationregulationofmicrotubule-basedprocessregulationofmodificationofpostsynapticstructureregulationofneuronprojectiondevelopmentregulationofneuronalsynapticplasticityregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationofosteoblastdifferentiationregulationofproteinexportfromnucleusresponsetozincionsignaltransductionstemcelldifferentiationsuperiortemporalgyrusdevelopmenttranscriptionbyRNApolymeraseIIWntsignalingpathway
Lethal(3)malignant brain tumor-like protein 3
8.3
66
46
LMBL3LMBL3Q96JM7Q96JM7chromatinorganizationerythrocytematurationgranulocytedifferentiationmacrophagedifferentiationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofubiquitin-dependentproteincatabolicprocessregulationofDNAmethylation-dependentheterochromatinformation
Dipeptidyl peptidase 8
8.2
74
44
DPP8DPP8Q6V1X1Q6V1X1apoptoticprocessimmuneresponseproteolysis
Transcription termination factor 4, mitochondrial
8.2
49
50
MTEF4MTEF4Q7Z6M4Q7Z6M4camera-typeeyedevelopmentheartdevelopmentmitochondrialtranscriptionproteintargetingtomitochondrionregulationofDNA-templatedtranscriptionribosomeassemblyrRNAprocessing
Caspase-3
3.3
84
69
CASP3CASP3P42574P42574anteriorneuraltubeclosureapoptoticprocessapoptoticsignalingpathwayaxonalfasciculationBcellhomeostasiscellfatecommitmentcellularresponsetoDNAdamagestimuluscellularresponsetostaurosporineepithelialcellapoptoticprocesserythrocytedifferentiationexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayfibroblastapoptoticprocessglialcellapoptoticprocessheartdevelopmenthippocampusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoosmoticstresskeratinocytedifferentiationlearningormemoryleukocyteapoptoticprocessluteolysisnegativeregulationofactivatedTcellproliferationnegativeregulationofBcellproliferationneuronapoptoticprocessneurondifferentiationneurotrophinTRKreceptorsignalingpathwayplateletformationpositiveregulationofamyloid-betaformationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessproteincatabolicprocessproteinprocessingproteolysisregulationofmacroautophagyregulationofproteinstabilityresponsetoaminoacidresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoglucocorticoidresponsetoglucoseresponsetohydrogenperoxideresponsetohypoxiaresponsetolipopolysaccharideresponsetonicotineresponsetotumornecrosisfactorresponsetoUVresponsetoX-rayresponsetoxenobioticstimulussensoryperceptionofsoundstriatedmusclecelldifferentiationTcellhomeostasiswoundhealing
Mismatch repair endonuclease PMS2
9.1
44
50
PMS2PMS2P54278P54278mismatchrepairresponsetoxenobioticstimulussomatichypermutationofimmunoglobulingenes
C-type lectin domain family 4 member A
2.0
47
87
CLC4ACLC4AQ9UMR7Q9UMR7adaptiveimmuneresponseantifungalinnateimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassICD8-positivealpha-betaTcellactivationcelladhesioncellsurfacereceptorsignalingpathwayimmuneresponsenegativeregulationofcytokineproductionnegativeregulationoftumornecrosisfactorproductionplasmacytoiddendriticcellantigenprocessingandpresentation
Exonuclease 1
9.6
62
39
EXO1EXO1Q9UQ84Q9UQ84DNArecombinationDNArepairhumoralimmuneresponsemediatedbycirculatingimmunoglobulinisotypeswitchingmeioticcellcyclemismatchrepairsomatichypermutationofimmunoglobulingenest-circleformation
DNA cross-link repair 1A protein
7.5
50
58
DCR1ADCR1AQ6PJP8Q6PJP8cellcyclecelldivisiondouble-strandbreakrepairvianonhomologousendjoininginterstrandcross-linkrepairprotectionfromnon-homologousendjoiningattelomere
Interleukin-8
2.0
45
88
IL8IL8P10145P10145angiogenesisantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcium-mediatedsignalingcellularresponsetofibroblastgrowthfactorstimuluscellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorchemokine-mediatedsignalingpathwaychemotaxisembryonicdigestivetractdevelopmentGprotein-coupledreceptorsignalingpathwayinductionofpositivechemotaxisinflammatoryresponseintracellularsignaltransductionkillingofcellsofanotherorganismnegativeregulationofcelladhesionmoleculeproductionnegativeregulationofcellpopulationproliferationnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofgeneexpressionneutrophilactivationneutrophilchemotaxispositiveregulationofangiogenesispositiveregulationofcellularbiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofneutrophilchemotaxisreceptorinternalizationregulationofcelladhesionregulationofentryofbacteriumintohostcellregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediateresponsetoendoplasmicreticulumstressresponsetomoleculeofbacterialoriginsignaltransduction
Probable dimethyladenosine transferase
8.2
85
36
DIM1DIM1Q9UNQ2Q9UNQ2positiveregulationofrRNAprocessingrRNAmethylation
Dual specificity protein kinase CLK3
8.2
64
46
CLK3CLK3P49761P49761peptidyl-tyrosinephosphorylationproteinautophosphorylationproteinphosphorylationregulationofRNAsplicing
Cyanocobalamin reductase / alkylcobalamin dealkylase
6.1
41
62
MMACMMACQ9Y4U1Q9Y4U1cobalaminmetabolicprocessdemethylationglutathionemetabolicprocess
Kinesin light chain 2
3.3
61
75
✔
KLC2KLC2Q9H0B6Q9H0B6lysosomelocalizationmicrotubule-basedmovement
1,4-alpha-glucan-branching enzyme
8.2
56
48
✔
GLGBGLGBQ04446Q04446carbohydratemetabolicprocessgenerationofprecursormetabolitesandenergyglycogenbiosyntheticprocessglycogenmetabolicprocessnegativeregulationofneuronapoptoticprocess
Chromodomain-helicase-DNA-binding protein 1
8.5
65
43
✔
CHD1CHD1O14646O14646chromatinremodelingnucleosomeorganizationpositiveregulationbyhostofviraltranscriptionregulationoftranscriptionbyRNApolymeraseII
Cyclin-dependent kinase-like 2
9.5
nan
47
CDKL2CDKL2Q92772Q92772proteinphosphorylationsexdifferentiationsignaltransduction
Signal transducer and activator of transcription 5B
8.2
52
52
STA5BSTA5BP51692P51692activatedTcellproliferationBcelldifferentiationcellularresponsetoepidermalgrowthfactorstimuluscellularresponsetogrowthfactorstimuluscellularresponsetohormonestimuluscytokine-mediatedsignalingpathwaydefenseresponsedevelopmentofsecondaryfemalesexualcharacteristicsdevelopmentofsecondarymalesexualcharacteristicserythrocytedifferentiationfemalepregnancygamma-deltaTcelldifferentiationgrowthhormonereceptorsignalingpathwayviaJAK-STATlactationlipidstorageluteinizationmastcellmigrationmitoticcellcyclemyeloidcellapoptoticprocessnaturalkillercelldifferentiationnaturalkillercellmediatedcytotoxicitynaturalkillercellproliferationnegativeregulationoferythrocytedifferentiationnegativeregulationofmyeloidcellapoptoticprocess"Peyerspatchdevelopment"positiveregulationofactivatedTcellproliferationpositiveregulationofBcelldifferentiationpositiveregulationoferythrocytedifferentiationpositiveregulationofgamma-deltaTcelldifferentiationpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-2productionpositiveregulationofmitoticcellcyclepositiveregulationofmulticellularorganismgrowthpositiveregulationofnaturalkillercelldifferentiationpositiveregulationofnaturalkillercellmediatedcytotoxicitypositiveregulationofnaturalkillercellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronemetabolicprocessreceptorsignalingpathwayviaJAK-STATregulationofcellpopulationproliferationregulationofepithelialcelldifferentiationregulationofmulticellularorganismgrowthregulationofsteroidmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIresponsetoestradiolresponsetointerleukin-15responsetointerleukin-2responsetointerleukin-4responsetopeptidehormoneTcelldifferentiationinthymusTcellhomeostasistaurinemetabolicprocesstranscriptionbyRNApolymeraseII
STAGA complex 65 subunit gamma
8.7
58
43
ST65GTAF10O94864Q12962histoneH3acetylationmaintenanceofproteinlocationinnucleusmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingallantoisdevelopmentapoptoticprocessDNA-templatedtranscriptioninitiationembryonicplacentadevelopmentG1/StransitionofmitoticcellcyclehepatocytedifferentiationhistoneacetylationlateralmesodermalcelldifferentiationlimbdevelopmentmRNAtranscriptionbyRNApolymeraseIImulticellularorganismgrowthpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinphosphorylationregulationofDNAbindingregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblySAGAcomplexassemblysomitogenesistranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoter
Phospholipase D2
8.2
57
44
PLD2PLD2O14939O14939cytoskeletonorganizationFc-gammareceptorsignalingpathwayinvolvedinphagocytosisinositollipid-mediatedsignalingphosphatidicacidbiosyntheticprocessphospholipidcatabolicprocessregulationofvesicle-mediatedtransportsmallGTPasemediatedsignaltransductionsynapticvesiclerecycling
Macrophage migration inhibitory factor
2.0
76
85
✔
MIFMIFP14174P14174carboxylicacidmetabolicprocesscellsurfacereceptorsignalingpathwaycellularsenescenceDNAdamageresponsesignaltransductionbyp53classmediatorinflammatoryresponseinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofcellmigrationnegativeregulationofcellularsenescencenegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofgeneexpressionnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofmacrophagechemotaxisnegativeregulationofmatureBcellapoptoticprocessnegativeregulationofmyeloidcellapoptoticprocessnegativeregulationofproteinmetabolicprocesspositiveregulationofarachidonicacidsecretionpositiveregulationofBcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofcytokineproductionpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationoflipopolysaccharide-mediatedsignalingpathwaypositiveregulationofMAPkinaseactivitypositiveregulationofmyeloidleukocytecytokineproductioninvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphosphorylationpositiveregulationofprostaglandinsecretioninvolvedinimmuneresponsepositiveregulationofproteinkinaseAsignalingpositiveregulationoftumornecrosisfactorproductionprostaglandinbiosyntheticprocessproteinhomotrimerizationregulationofmacrophageactivation
Lethal(3)malignant brain tumor-like protein 1
8.2
66
43
LMBL1LMBL1Q9Y468Q9Y468chromatinorganizationhemopoiesisheterochromatinformationnegativeregulationofDNA-templatedtranscriptionregulationofcellcycleregulationofmegakaryocytedifferentiationregulationofmitoticnucleardivision
NAD-dependent malic enzyme, mitochondrial
8.2
81
37
MAOMMAOMP23368P23368malatemetabolicprocesspyruvatemetabolicprocessregulationofNADPmetabolicprocess
ETS-related transcription factor Elf-3
8.2
54
51
ELF3ELF3Q6IAP8Q6IAP8blastocystdevelopmentcelldifferentiationextracellularmatrixorganizationinflammatoryresponsemammaryglandinvolutionnegativeregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Phosphatidylinositol 4-kinase alpha
8.2
74
38
PI4KATTC7BP42356Q86TV6modulationbyhostofviralprocessphosphatidylinositolbiosyntheticprocessphosphatidylinositolphosphatebiosyntheticprocessphosphatidylinositol-mediatedsignalingphosphorylationreorganizationofcellularmembranestoestablishviralsitesofreplicationsignaltransductionproteinlocalizationtoplasmamembrane
Galectin-9
8.2
56
46
LEG9LEG9O00182O00182cellularresponsetotypeIIinterferoncellularresponsetoviruschemotaxisERK1andERK2cascadefemalepregnancyinflammatoryresponsematernalprocessinvolvedinfemalepregnancynaturalkillercelltoleranceinductionnegativeregulationofactivatedTcellproliferationnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofchemokineproductionnegativeregulationofgeneexpressionnegativeregulationofmastcelldegranulationnegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionp38MAPKcascadepositiveregulationofactivatedTcellautonomouscelldeathpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofCD4-positiveCD25-positivealpha-betaregulatoryTcelldifferentiationinvolvedinimmuneresponsepositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaypositiveregulationofdendriticcellapoptoticprocesspositiveregulationofdendriticcellchemotaxispositiveregulationofdendriticcelldifferentiationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-4productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmonocytechemotacticprotein-1productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofTcellactivationviaTcellreceptorcontactwithantigenboundtoMHCmoleculeonantigenpresentingcellpositiveregulationoftransforminggrowthfactorbetaproductionpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationofviralentryintohostcellresponsetointerleukin-1responsetolipopolysaccharide
Tyrosine-protein kinase JAK3
8.2
65
41
✔
JAK3JAK3P52333P52333adaptiveimmuneresponseBcelldifferentiationcelldifferentiationcytokine-mediatedsignalingpathwayenzyme-linkedreceptorproteinsignalingpathwayerythrocytedifferentiationgrowthhormonereceptorsignalingpathwayviaJAK-STATinnateimmuneresponseinterleukin-2-mediatedsignalingpathwayinterleukin-4-mediatedsignalingpathwayintracellularsignaltransductionnegativeregulationofdendriticcellcytokineproductionnegativeregulationofFasLproductionnegativeregulationofinterleukin-10productionnegativeregulationofinterleukin-12productionnegativeregulationofTcellactivationnegativeregulationofT-helper1celldifferentiationnegativeregulationofthymocyteapoptoticprocesspeptidyl-tyrosinephosphorylationpositiveregulationofactivatedTcellproliferationpositiveregulationofcalciumiontransportpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinphosphorylationreceptorsignalingpathwayviaJAK-STATregulationofapoptoticprocessregulationofreceptorsignalingpathwayviaJAK-STATregulationofTcellapoptoticprocessresponsetointerleukin-15responsetointerleukin-2responsetointerleukin-4responsetointerleukin-9TcellhomeostasistyrosinephosphorylationofSTATprotein
H/ACA ribonucleoprotein complex subunit 1
8.2
71
41
✔
GAR1GAR1Q9NY12Q9NY12snoRNAguidedrRNApseudouridinesynthesistelomeremaintenanceviatelomerase
UDP-N-acetylhexosamine pyrophosphorylase
8.3
82
33
✔
UAP1UAP1Q16222Q16222UDP-N-acetylglucosaminebiosyntheticprocess
Protein NDRG3
2.0
54
87
NDRG3NDRG3Q9UGV2Q9UGV2celldifferentiationnegativeregulationofcellgrowthsignaltransductionspermatogenesis
Tyrosine-protein kinase Mer
8.3
85
35
MERTKMERTKQ12866Q12866cellmigrationcellsurfacereceptorsignalingpathwaycell-cellsignalingestablishmentoflocalizationincellnaturalkillercelldifferentiationnegativeregulationofcytokineproductionnegativeregulationofleukocyteapoptoticprocessnegativeregulationoflymphocyteactivationnervoussystemdevelopmentneutrophilclearancephagocytosisplateletactivationpositiveregulationofkinaseactivitypositiveregulationofphagocytosisproteinkinaseBsignalingproteinphosphorylationretinadevelopmentincamera-typeeyesecretionbycellspermatogenesissubstrateadhesion-dependentcellspreadingtransmembranereceptorproteintyrosinekinasesignalingpathwayvaginadevelopment
rRNA N6-adenosine-methyltransferase METTL5
9.8
56
35
METL5METL5Q9NRN9Q9NRN9positiveregulationoftranslationrRNAmethylationstemcelldifferentiation
N-glycosylase/DNA lyase
8.5
68
44
OGG1OGG1O15527O15527acuteinflammatoryresponseagingbase-excisionrepairbase-excisionrepairAPsiteformationcellularresponsetocadmiumioncellularresponsetoDNAdamagestimulusdepurinationdepyrimidinationnegativeregulationofapoptoticprocessnegativeregulationofdouble-strandbreakrepairviasingle-strandannealingnucleotide-excisionrepairDNAincisionregulationofDNA-templatedtranscriptionresponsetoestradiolresponsetoethanolresponsetofolicacidresponsetolightstimulusresponsetooxidativestressresponsetoradiationresponsetoxenobioticstimulus
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
8.3
90
34
OXSMOXSMQ9NWU1Q9NWU1acyl-CoAmetabolicprocessfattyacidbiosyntheticprocessmedium-chainfattyacidbiosyntheticprocessshort-chainfattyacidbiosyntheticprocess
BEN domain-containing protein 3
6.6
68
54
BEND3BEND3Q6PAL0Q6PAL0DNAmethylationhistoneH3-K27trimethylationhistoneH3-K4trimethylationhistoneH3-K9trimethylationhistoneH4acetylationhistoneH4-K20trimethylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofATPmetabolicprocessproteinhomooligomerizationrDNAheterochromatinformation
Gamma-tubulin complex component 6
8.3
43
50
GCP6GCP6Q96RT7Q96RT7cytoplasmicmicrotubuleorganizationmeioticcellcyclemicrotubulenucleationmitoticcellcyclespindleassembly
U3 small nucleolar RNA-associated protein 15 homolog
8.3
90
39
UTP15UTP15Q8TED0Q8TED0positiveregulationofrRNAprocessingpositiveregulationoftranscriptionbyRNApolymeraseIrRNAprocessing
Lysine-specific demethylase 3B
8.3
58
49
KDM3BKDM3BQ7LBC6Q7LBC6chromatinorganizationhistoneH3-K9demethylationregulationoftranscriptionbyRNApolymeraseII
FERM, ARHGEF and pleckstrin domain-containing protein 1
8.3
57
46
FARP1FARP1Q9Y4F1Q9Y4F1dendritemorphogenesispostsynapticactincytoskeletonorganizationregulationofpresynapseassemblyretrogradetrans-synapticsignalingbytrans-synapticproteincomplexsynapseassembly
Anaphase-promoting complex subunit 7
8.3
61
47
APC7APC7Q9UJX3Q9UJX3anaphase-promotingcomplex-dependentcatabolicprocessbraindevelopmentcelldivisionmetaphase/anaphasetransitionofmitoticcellcyclepositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationproteinubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycle
Retinoid-binding protein 7
8.3
58
49
RET7RET7Q96R05Q96R05fattyacidtransport
Symplekin
8.3
65
41
SYMPKSYMPKQ92797Q92797celladhesionmRNApolyadenylationnegativeregulationofproteinbindingpositiveregulationofproteindephosphorylation
Structural maintenance of chromosomes protein
8.3
67
43
G8JLG1G8JLG1G8JLG1G8JLG1meioticcellcyclesisterchromatidcohesion
Acylamino-acid-releasing enzyme
6.4
100
44
ACPHACPHP19205P19205proteolysis
Trafficking protein particle complex subunit 6A
8.3
77
36
TPC6ATPC6AO75865O75865COPIIvesiclecoatingendoplasmicreticulumtoGolgivesicle-mediatedtransportregulationofGTPaseactivityvesicletethering
Cysteine sulfinic acid decarboxylase
8.9
72
38
CSADCSADQ9DBE0Q9DBE0L-cysteinecatabolicprocesstohypotaurineL-cysteinecatabolicprocesstotaurinetaurinebiosyntheticprocesstaurinemetabolicprocess
39S ribosomal protein L19, mitochondrial
8.3
76
36
I3LNJ0I3LNJ0I3LNJ0I3LNJ0translation
Elongin-C
8.6
nan
53
SOCS3ELOCO35718P83940branchinginvolvedinlabyrinthinelayermorphogenesiscelldifferentiationcellularresponsetointerleukin-17cellularresponsetoleukemiainhibitoryfactorintracellularsignaltransductionnegativeregulationofinflammatoryresponsenegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofsignaltransductionnegativeregulationoftyrosinephosphorylationofSTATproteinphosphatidylinositolphosphatebiosyntheticprocessplacentabloodvesseldevelopmentpositiveregulationofcelldifferentiationproteinubiquitinationreceptorsignalingpathwayviaJAK-STATregulationofproteinphosphorylationsignaltransductiontranscriptioninitiationatRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
Lymphokine-activated killer T-cell-originated protein kinase
8.3
40
53
TOPKTOPKQ96KB5Q96KB5cellularresponsetoUVmitoticcellcyclenegativeregulationofinflammatoryresponsenegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinphosphorylationnegativeregulationofstress-activatedMAPKcascadep38MAPKcascadepeptidyl-serinephosphorylationpositiveregulationofmitoticDNAdamagecheckpointproteasome-mediatedubiquitin-dependentproteincatabolicprocess
DNA excision repair protein ERCC-5
8.3
66
41
ERCC5ERCC5P28715P28715base-excisionrepairAPsiteformationdouble-strandbreakrepairviahomologousrecombinationnegativeregulationofapoptoticprocessnucleotide-excisionrepair"nucleotide-excisionrepairDNAincision5-tolesion"regulationofcatalyticactivityresponsetoUVresponsetoUV-Ctranscription-couplednucleotide-excisionrepair
Antizyme inhibitor 1
4.6
72
65
AZIN1AZIN1O35484O35484negativeregulationofproteincatabolicprocesspolyaminemetabolicprocesspositiveregulationofcentrosomeduplicationpositiveregulationofepithelialcellproliferationpositiveregulationofpolyaminetransmembranetransportputrescinebiosyntheticprocessfromornithine
ER membrane protein complex subunit 5
8.3
79
37
✔
EMC5EMC6Q8N4V1Q9BV81copperiontransportmagnesiumiontransportproteininsertionintoERmembranebystop-transfermembrane-anchorsequencetail-anchoredmembraneproteininsertionintoERmembraneautophagosomeassembly
Acyl-coenzyme A thioesterase THEM5
8.3
86
36
THEM5THEM5Q8N1Q8Q8N1Q8cardiolipinacyl-chainremodelingfattyacidmetabolicprocesslong-chainfatty-acyl-CoAmetabolicprocess
RNA N6-adenosine-methyltransferase METTL16
4.5
85
61
MET16MET16Q86W50Q86W50mRNAcatabolicprocessmRNAdestabilizationmRNAmethylation"negativeregulationof3-UTR-mediatedmRNAstabilization"post-transcriptionalregulationofgeneexpressionregulationofmRNAsplicingviaspliceosomerRNAbasemethylationS-adenosylmethioninebiosyntheticprocesssnRNA(adenine-N6)-methylation
BRISC and BRCA1-A complex member 1
8.3
64
42
BABA1BABA1Q9NWV8Q9NWV8celldivisionchromatinorganizationdouble-strandbreakrepairhematopoieticstemcellproliferationhistoneH2AK63-linkeddeubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointpositiveregulationofDNArepairproteinK63-linkeddeubiquitinationregulationofDNArepairresponsetoionizingradiation
Kelch-like protein 17
8.3
84
39
KLH17KLH17Q6TDP4Q6TDP4actincytoskeletonorganizationbraindevelopmentproteinubiquitinationregulationproteincatabolicprocessatpostsynapse
Elongator complex protein 1
5.2
72
54
ELP1ELP1Q7TT37Q7TT37I-kappaBphosphorylationtRNAwobblebase5-methoxycarbonylmethyl-2-thiouridinylationtRNAwobbleuridinemodification
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
9.7
77
36
HCN4HCN4Q9Y3Q4Q9Y3Q4bloodcirculationcationtransportcellularresponsetocAMPcellularresponsetocGMPmembranedepolarizationduringcardiacmusclecellactionpotentialmembranedepolarizationduringSAnodecellactionpotentialmusclecontractionpotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportregulationofcardiacmusclecellactionpotentialinvolvedinregulationofcontractionregulationofcardiacmusclecontractionregulationofcationchannelactivityregulationofheartrateregulationofheartratebycardiacconductionregulationofmembranedepolarizationregulationofmembranepotentialregulationofSAnodecellactionpotentialSAnodecellactionpotentialsinoatrialnodedevelopmentsodiumionimportacrossplasmamembranesodiumiontransmembranetransport
GMP synthase [glutamine-hydrolyzing]
8.9
65
39
GUAAGUAAP49915P49915glutaminemetabolicprocessGMPbiosyntheticprocesspurinenucleobasebiosyntheticprocesspurineribonucleosidemonophosphatebiosyntheticprocess
Protein unc-119 homolog A
8.4
57
49
U119AU119AQ13432Q13432chemicalsynaptictransmissionendocytosislipoproteintransportmitoticcytokinesisnegativeregulationofcaveolin-mediatedendocytosisnegativeregulationofclathrin-dependentendocytosisnervoussystemdevelopmentphototransductionpositiveregulationofproteintyrosinekinaseactivityvisualperception
Insulin-like growth factor 2 mRNA-binding protein 3
8.4
85
37
✔
IF2B3IF2B3O00425O00425anatomicalstructuremorphogenesisCRD-mediatedmRNAstabilizationmRNAtransportnegativeregulationoftranslationnervoussystemdevelopmentregulationofcytokineproductionregulationofgeneexpressionregulationofRNAmetabolicprocesstranslation
40S ribosomal protein S6
8.4
65
38
G1TM55G1TM55G1TM55G1TM55activation-inducedcelldeathofTcellscytoplasmictranslationerythrocytedevelopmentG1/StransitionofmitoticcellcyclegastrulationglucosehomeostasismammalianoogenesisstagenegativeregulationofapoptoticprocessplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcellpopulationproliferationribosomalsmallsubunitbiogenesisrRNAprocessingTcelldifferentiationinthymusTcellproliferationinvolvedinimmuneresponseTORsignaling
Toll-like receptor 2
2.0
51
87
TLR2TLR2Q9QUN7Q9QUN7cellactivationcellsurfacepatternrecognitionreceptorsignalingpathwaycellularresponsetobacteriallipopeptidecellularresponsetodiacylbacteriallipopeptidecellularresponsetolipoteichoicacidcellularresponsetopeptidoglycancellularresponsetotriacylbacteriallipopeptidecellularresponsetotypeIIinterferoncentralnervoussystemmyelinformationdefenseresponsedefenseresponsetoGram-positivebacteriumdetectionofdiacylbacteriallipopeptidedetectionoftriacylbacteriallipopeptideERK1andERK2cascadeI-kappaBphosphorylationinflammatoryresponseinnateimmuneresponselearningleukocytemigrationleukotrienemetabolicprocessmicrogliadevelopmentmicroglialcellactivationMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofactinfilamentpolymerizationnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-17productionnegativeregulationofphagocytosisnegativeregulationofsynapseassemblyneutrophilmigrationNIK/NF-kappaBsignalingnitricoxidebiosyntheticprocessnitricoxidemetabolicprocesspositiveregulationofcellularresponsetomacrophagecolony-stimulatingfactorstimuluspositiveregulationofchemokineproductionpositiveregulationofcytokineproductionpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-18productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofleukocytemigrationpositiveregulationofmacrophagecytokineproductionpositiveregulationofmatrixmetallopeptidasesecretionpositiveregulationofneutrophilmigrationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthasebiosyntheticprocesspositiveregulationofoligodendrocytedifferentiationpositiveregulationoftoll-likereceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofWntsignalingpathwaypositiveregulationofxenophagyregulationofdendriticcellcytokineproductionresponsetobacteriallipoproteinresponsetobacteriumresponsetofattyacidresponsetomoleculeoffungaloriginresponsetopeptidoglycantoll-likereceptorsignalingpathwaytoll-likereceptorTLR6xenophagy
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
8.7
nan
55
CTDS2CTDS2O14595O14595negativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofproteinphosphorylationproteindephosphorylation
Serine--tRNA ligase, mitochondrial
9.2
38
48
SYSMSYSMQ9NP81Q9NP81mitochondrialseryl-tRNAaminoacylationselenocysteinyl-tRNA(Sec)biosyntheticprocessseryl-tRNAaminoacylation
Aldehyde dehydrogenase family 3 member A2
8.4
61
43
AL3A2AL3A2P51648P51648cellularaldehydemetabolicprocesscentralnervoussystemdevelopmentepidermisdevelopmentfattyacidmetabolicprocesshexadecanalmetabolicprocessperipheralnervoussystemdevelopmentphytolmetabolicprocesssesquiterpenoidmetabolicprocess
Glyoxylate reductase/hydroxypyruvate reductase
8.4
70
41
✔
GRHPRGRHPRQ9UBQ7Q9UBQ7carboxylicacidmetabolicprocessdicarboxylicacidmetabolicprocessglyoxylatemetabolicprocess
GTP-binding protein GEM
8.4
64
47
GEMGEMP55040P55040cellsurfacereceptorsignalingpathwaychromosomeorganizationimmuneresponsemetaphaseplatecongressionmitoticcellcyclenegativeregulationofhighvoltage-gatedcalciumchannelactivitysignaltransduction
Guanidinoacetate N-methyltransferase
9.8
62
38
GAMTGAMTP10868P10868animalorganmorphogenesiscreatinebiosyntheticprocessembryonicliverdevelopmentmethylationregulationofmulticellularorganismgrowthS-adenosylhomocysteinemetabolicprocessS-adenosylmethioninemetabolicprocessspermatogenesis
Tripartite motif-containing protein 72
8.4
71
40
TRI72TRI72Q6ZMU5Q6ZMU5exocytosismuscleorgandevelopmentmusclesystemprocessnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofmyotubedifferentiationplasmamembranerepairproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinhomooligomerizationproteinubiquitination
28S ribosomal protein S2, mitochondrial
8.4
70
42
F1S001F1S001F1S001F1S001mitochondrialribosomeassemblytranslation
cAMP-dependent protein kinase catalytic subunit alpha
5.1
69
61
Q8K1M3KAPCAQ8K1M3P05132phosphorylationadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetocoldcellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimulusmesodermformationmodulationofchemicalsynaptictransmissionmRNAprocessingnegativeregulationofmeioticcellcyclenegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofinsulinsecretionpositiveregulationofproteinexportfromnucleuspostsynapticmodulationofchemicalsynaptictransmissionproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcellcycleregulationofcellularrespirationregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinprocessingregulationofsynaptictransmissionglutamatergicspermcapacitationspontaneousexocytosisofneurotransmitter
Intersectin 2
8.4
72
45
A6H8W8A6H8W8A6H8W8A6H8W8endocytosis
Dual specificity protein kinase CLK4
9.6
67
42
CLK4CLK4Q9HAZ1Q9HAZ1peptidyl-tyrosinephosphorylationproteinautophosphorylationproteinphosphorylationregulationofRNAsplicing
Calcitonin gene-related peptide 1
2.0
68
85
CALCACALCAP06881P06881activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwayantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecalcitoningene-relatedpeptidereceptorsignalingpathwaycell-cellsignalingdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumendothelialcellmigrationendothelialcellproliferationGprotein-coupledreceptorinternalizationinnateimmuneresponseleukocytecell-celladhesionnegativeregulationofbloodpressurenegativeregulationofboneresorptionnegativeregulationofcalciumiontransportintocytosolnegativeregulationofosteoclastdifferentiationnervoussystemprocessinvolvedinregulationofsystemicarterialbloodpressurepositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-8productionpositiveregulationofmacrophagedifferentiationproteinphosphorylationreceptorinternalizationregulationofbloodpressureregulationofcytosoliccalciumionconcentrationresponsetoyeastvasculaturedevelopmentvasodilation
M-phase inducer phosphatase 3
6.2
78
53
MPIP3MPIP3P30307P30307celldivisioncellpopulationproliferationG2/MtransitionofmitoticcellcyclepositiveregulationofG2/MtransitionofmitoticcellcyclepositiveregulationofG2/MItransitionofmeioticcellcycleproteindephosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofmitoticnucleardivisionspermatogenesis
Cellular retinoic acid-binding protein 2
8.4
65
43
RABP2RABP2P29373P29373embryonicforelimbmorphogenesisepidermisdevelopmentfattyacidtransportpositiveregulationofcollateralsproutingregulationofDNA-templatedtranscriptionretinoicacidbiosyntheticprocesssignaltransduction
Histidine--tRNA ligase, cytoplasmic
8.4
87
33
HARS1HARS1P12081P12081histidyl-tRNAaminoacylationmitochondrialtranslationtranslationtRNAaminoacylationforproteintranslation
Protein S100-A5
8.4
72
41
S10A5S10A5P33763P33763
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
8.4
80
39
F263F263Q16875Q16875braindevelopmentfructose26-bisphosphatemetabolicprocessfructosemetabolicprocess
T-complex protein 1 subunit epsilon
8.4
70
38
✔
TCPETCPEP48643P48643bindingofspermtozonapellucidachaperone-mediatedproteinfoldingpositiveregulationofestablishmentofproteinlocalizationtotelomerepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationoftelomeraseRNAlocalizationtoCajalbodypositiveregulationoftelomeremaintenanceviatelomeraseproteinfoldingproteinstabilizationresponsetovirustoxintransport
Sonic hedgehog protein
8.4
89
34
SHHSHHQ15465Q15465alpha-betaTcelldifferentiationalpha-tubulinacetylationandrogenmetabolicprocessanimalorganformationapoptoticsignalingpathwayarterydevelopmentaxonguidanceBergmannglialcelldifferentiationbloodcoagulationbranchinginvolvedinbloodvesselmorphogenesisbranchinginvolvedinsalivaryglandmorphogenesisbranchinginvolvedinuretericbudmorphogenesisbranchingmorphogenesisofanepithelialtubebudoutgrowthinvolvedinlungbranchingcamera-typeeyedevelopmentcanonicalWntsignalingpathwayCD4-positiveorCD8-positivealpha-betaTcelllineagecommitmentcelldevelopmentcellfatespecificationcell-cellsignalingcellularresponsetolithiumioncentralnervoussystemdevelopmentcerebellargranulecellprecursorproliferationdeterminationofleft/rightasymmetryinlateralmesodermdopaminergicneurondifferentiationdorsal/ventralneuraltubepatterningdorsal/ventralpatternformationectodermdevelopmentembryonicdigestivetractmorphogenesisembryonicdigitmorphogenesisembryonicforegutmorphogenesisembryonicforelimbmorphogenesisembryonichindlimbmorphogenesisembryoniclimbmorphogenesisembryonicpatternspecificationembryonicskeletalsystemdevelopmentendocytosisepithelialcellproliferationinvolvedinprostateglanddevelopmentepithelialcellproliferationinvolvedinsalivaryglandmorphogenesisepithelial-mesenchymalsignalinginvolvedinprostateglanddevelopmentestablishmentofepithelialcellpolarityforebraindevelopmentformationofanatomicalboundaryhairfolliclemorphogenesisheartdevelopmentheartloopinghindbraindevelopmenthindgutmorphogenesisinnereardevelopmentintein-mediatedproteinsplicingintermediatefilamentorganizationleftlungdevelopmentlimbbudformationlungdevelopmentlungepitheliumdevelopmentlunglobemorphogenesislung-associatedmesenchymedevelopmentlymphoidprogenitorcelldifferentiationmalegenitaliadevelopmentmesenchymalcellapoptoticprocessmesenchymalcellproliferationinvolvedinlungdevelopmentmesenchymalsmoothenedsignalingpathwayinvolvedinprostateglanddevelopmentmetanephriccollectingductdevelopmentmetanephricmesenchymalcellproliferationinvolvedinmetanephrosdevelopmentmetanephrosdevelopmentmidbraindevelopmentmyoblastdifferentiationnegativeregulationofalpha-betaTcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationofcellmigrationnegativeregulationofcholesteroleffluxnegativeregulationofdopaminergicneurondifferentiationnegativeregulationofgeneexpressionnegativeregulationofkidneysmoothmusclecelldifferentiationnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofTcelldifferentiationinthymusnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionelongationbyRNApolymeraseIInegativeregulationofuretersmoothmusclecelldifferentiationnegativethymicTcellselectionneuralcrestcellmigrationneuroblastproliferationneuronfatecommitmentodontogenesisofdentin-containingtootholigodendrocytedevelopmentoligodendrocytedifferentiationosteoblastdevelopmentpancreasdevelopmentpatternspecificationprocesspolarityspecificationofanterior/posterioraxispositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofastrocytedifferentiationpositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentpositiveregulationofgeneexpressionpositiveregulationofhhtargettranscriptionfactoractivitypositiveregulationofimmatureTcellproliferationinthymuspositiveregulationofkidneysmoothmusclecelldifferentiationpositiveregulationofmesenchymalcellproliferationinvolvedinureterdevelopmentpositiveregulationofneuroblastproliferationpositiveregulationofoligodendrocytedifferentiationpositiveregulationofproteinimportintonucleuspositiveregulationofsclerotomedevelopmentpositiveregulationofskeletalmusclecellproliferationpositiveregulationofskeletalmuscletissuedevelopmentpositiveregulationofsmoothenedsignalingpathwaypositiveregulationofstriatedmusclecelldifferentiationpositiveregulationofTcelldifferentiationinthymuspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretersmoothmusclecelldifferentiationpositiveregulationofWntsignalingpathwaypositivethymicTcellselectionprimaryprostaticbudelongationprostateepithelialcordelongationprostateglanddevelopmentproteinautoprocessingproteinimportintonucleusregulationofcellpopulationproliferationregulationofgeneexpressionregulationofglialcellproliferationregulationofmesenchymalcellproliferationinvolvedinprostateglanddevelopmentregulationofnodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetryregulationofodontogenesisregulationofprostaticbudformationregulationofproteinlocalizationtonucleusregulationofproteolysisregulationofstemcellproliferationrightlungdevelopmentroofofmouthdevelopmentsalivaryglandcavitationselfproteolysisskeletalmusclecellproliferationskeletalmusclefiberdifferentiationsmoothmuscletissuedevelopmentsmoothenedsignalingpathwaysmoothenedsignalingpathwayinvolvedinregulationofcerebellargranulecellprecursorcellproliferationsomitedevelopmentspinalcorddorsal/ventralpatterningspinalcordmotorneurondifferentiationstemcelldevelopmentstemcellproliferationstriatedmuscletissuedevelopmentTcelldifferentiationinthymusTcellproliferationtelencephalonregionalizationthalamusdevelopmentthymusdevelopmentthyroidglanddevelopmenttracheamorphogenesistracheoesophagealseptumformationtrunkneuralcrestcellmigrationvasculogenesisventralmidlinedevelopment
Indian hedgehog protein
8.4
92
34
IHHIHHQ14623Q14623boneresorptionbranchinginvolvedinbloodvesselmorphogenesiscamera-typeeyephotoreceptorcellfatecommitmentcartilagedevelopmentcellfatespecificationcellmaturationcell-cellsignalingchondrocytedifferentiationinvolvedinendochondralbonemorphogenesischondrocyteproliferationembryoniccamera-typeeyemorphogenesisembryonicdigestivetractmorphogenesisembryonicdigitmorphogenesisembryonicpatternspecificationembryonicskeletaljointdevelopmentepithelialcellmorphogenesisepithelialcell-celladhesionheadmorphogenesisheartloopinginuteroembryonicdevelopmentintein-mediatedproteinsplicingliverregenerationmaternalprocessinvolvedinfemalepregnancymulticellularorganismgrowthnegativeregulationofalpha-betaTcelldifferentiationnegativeregulationofapoptoticprocessnegativeregulationofchondrocytedifferentiationnegativeregulationofeyepigmentationnegativeregulationofimmatureTcellproliferationinthymusnegativeregulationofTcelldifferentiationinthymusneurondevelopmentosteoblastdifferentiationpancreasdevelopmentpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofepithelialcellproliferationpositiveregulationofmesenchymalcellproliferationpositiveregulationofsmoothenedsignalingpathwaypositiveregulationofTcelldifferentiationinthymuspositiveregulationoftranscriptionbyRNApolymeraseIIproteinautoprocessingproteoglycanmetabolicprocessregulationofgeneexpressionregulationofgrowthresponsetoestradiolresponsetomechanicalstimulusretinalpigmentepitheliumdevelopmentselfproteolysisskeletalsystemdevelopmentsmoothmuscletissuedevelopmentsmoothenedsignalingpathwaysomitedevelopmentvitellinemembraneformation
Signal transducer and activator of transcription 3
8.4
75
36
✔
STAT3STAT3P40763P40763astrocytedifferentiationcellpopulationproliferationcellularresponsetohormonestimuluscellularresponsetointerleukin-17cellularresponsetoleptinstimuluscytokine-mediatedsignalingpathwaydefenseresponseeatingbehaviorenergyhomeostasiseyephotoreceptorcelldifferentiationglucosehomeostasisgrowthhormonereceptorsignalingpathwaygrowthhormonereceptorsignalingpathwayviaJAK-STATinflammatoryresponseinterleukin-6-mediatedsignalingpathwayintracellularreceptorsignalingpathwayleptin-mediatedsignalingpathwaymRNAtranscriptionbyRNApolymeraseIInegativeregulationofautophagynegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofglycolyticprocessnegativeregulationofneuronmigrationnegativeregulationofprimarymiRNAprocessingnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentphosphorylationpositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofDNA-templatedtranscriptionpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmetalloendopeptidaseactivitypositiveregulationofmiRNAtranscriptionpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNotchsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofvascularendothelialcellproliferationproteinimportintonucleusradialglialcelldifferentiationreceptorsignalingpathwayviaJAK-STATregulationofcellcycleregulationofcellpopulationproliferationregulationofDNA-templatedtranscriptionregulationoffeedingbehaviorregulationofmulticellularorganismgrowthregulationoftranscriptionbyRNApolymeraseIIresponsetoestradiolresponsetoleptinresponsetopeptidehormoneretinalrodcelldifferentiationsexualreproductionsignaltransductionsomaticstemcellpopulationmaintenanceT-helper17celllineagecommitmentT-helper17typeimmuneresponsetemperaturehomeostasistransforminggrowthfactorbetareceptorsignalingpathway
Centromere-associated protein E
8.5
95
27
CENPECENPEQ02224Q02224attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionchromosomesegregationkinetochoreassemblylateralattachmentofmitoticspindlemicrotubulestokinetochoremetaphaseplatecongressionmicrotubuleplus-enddirectedmitoticchromosomemigrationmicrotubule-basedmovementmitoticcellcyclemitoticchromosomemovementtowardsspindlepolemitoticmetaphaseplatecongressionmitoticspindleorganizationpositiveregulationofproteinkinaseactivityregulationofmitoticmetaphase/anaphasetransition
PH-interacting protein
8.5
68
42
PHIPPHIPQ8WWQ0Q8WWQ0cytoskeletonorganizationinsulinreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofinsulin-likegrowthfactorreceptorsignalingpathwaypositiveregulationofmitoticnucleardivisionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellmorphogenesisregulationofcellshaperegulationofproteinphosphorylationregulationoftranscriptionbyRNApolymeraseII
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
8.5
50
46
PP2AAPP2AAP67775P67775apoptoticprocessceramidemetabolicprocessmeioticcellcyclemesodermdevelopmentmitoticcellcyclenegativeregulationofcellgrowthnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofproteinkinaseBsignalingnegativeregulationoftyrosinephosphorylationofSTATproteinpeptidyl-serinedephosphorylationpeptidyl-threoninedephosphorylationpositiveregulationofmicrotubulebindingpositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofproteinserine/threoninekinaseactivityproteindephosphorylationregulationofcelladhesionregulationofcelldifferentiationregulationofDNAreplicationregulationofDNA-templatedtranscriptionregulationofG1/StransitionofmitoticcellcycleregulationofgrowthregulationofmicrotubulebindingregulationofproteinphosphorylationregulationofWntsignalingpathwayresponsetoleadionresponsetoorganicsubstanceRNAsplicingsecond-messenger-mediatedsignaling
Tight junction protein ZO-1
8.5
39
51
ZO1ZO1Q07157Q07157actomyosinstructureorganizationadherensjunctionmaintenancecell-celladhesioncell-celljunctionassemblycell-celljunctionorganizationestablishmentofendothelialintestinalbarriermaintenanceofblood-brainbarriernegativeregulationofactincytoskeletonreorganizationnegativeregulationofapoptoticprocessnegativeregulationofstressfiberassemblypositiveregulationofblood-brainbarrierpermeabilitypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-celladhesionmediatedbycadherinpositiveregulationofsproutingangiogenesisproteinlocalizationtoadherensjunctionproteinlocalizationtobicellulartightjunctionproteinlocalizationtocell-celljunctionregulationofbicellulartightjunctionassemblyregulationofcelljunctionassemblyregulationofcytoskeletonorganization
COP9 signalosome complex subunit 1
8.5
62
47
CSN1CSN1Q13098Q13098JNKcascadeproteindeneddylationproteinneddylationregulationofproteinneddylation
Enoyl-CoA delta isomerase 2
8.5
79
35
✔
ECI2ECI2O75521O75521fattyacidbeta-oxidationfattyacidcatabolicprocessfattyacidmetabolicprocess
ATP-dependent RNA helicase DDX19B
8.5
78
35
DD19BDD19BQ9UMR2Q9UMR2mRNAexportfromnucleuspoly(A)+mRNAexportfromnucleus
Ras-related protein Rab-4B
8.5
86
43
RAB4BRAB4BP61018P61018glucoseimportproteintransportRabproteinsignaltransductionregulationofendocytosisvesicle-mediatedtransport
Ataxin-1
8.6
60
49
ATX1ATX1P54253P54253anatomicalstructuredevelopmentbraindevelopmentlearningmemorynegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentnuclearexportregulationofDNA-templatedtranscriptionRNAprocessingsocialbehavior
Dimethyladenosine transferase 2, mitochondrial
10.0
46
48
✔
RPOMTFB2MO00411Q9H5Q4mitochondrialtranscriptiontranscriptioninitiationatmitochondrialpromoterrRNAmethylation
Peroxisomal multifunctional enzyme type 2
6.7
73
53
DHB4DHB4P51659P51659androgenmetabolicprocessestrogenmetabolicprocessfattyacidbeta-oxidationmedium-chainfatty-acyl-CoAmetabolicprocessosteoblastdifferentiationSertolicelldevelopmentverylong-chainfattyacidmetabolicprocessverylong-chainfatty-acyl-CoAmetabolicprocess
Peptidyl-prolyl cis-trans isomerase FKBP2
2.0
38
87
FKBP2FKBP2P26885P26885chaperone-mediatedproteinfoldingproteinpeptidyl-prolylisomerization
Actin-related protein 10
3.6
73
74
ARP10ARP10I3LHK5I3LHK5microtubule-basedmovementretrogradeaxonaltransportofmitochondrion
Inactive tyrosine-protein kinase 7
8.5
73
41
PTK7PTK7Q13308Q13308actincytoskeletonreorganizationaxiselongationcelladhesioncellmigrationcellularresponsetoretinoicacidcochleamorphogenesisconvergentextensioncoronaryvasculaturedevelopmentestablishmentofepithelialcellapical/basalpolarityestablishmentofplanarpolaritykidneydevelopmentlung-associatedmesenchymedevelopmentplanarcellpolaritypathwayinvolvedinneuraltubeclosurepositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofneuronprojectiondevelopmentproteinphosphorylationregulationofcanonicalWntsignalingpathwaysignaltransductionventricularseptumdevelopmentwoundhealing
Period circadian protein homolog 1
8.5
77
39
PER1PER1O35973O35973circadianregulationofgeneexpressioncircadianregulationoftranslationcircadianrhythmentrainmentofcircadianclockbyphotoperiodhistoneH3acetylationhistoneH3deacetylationhistoneH4acetylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofJNKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIpost-transcriptionalregulationofgeneexpressionregulationofcircadianrhythmregulationofcytokineproductioninvolvedininflammatoryresponseregulationofhaircycleregulationofp38MAPKcascaderegulationofsodiumiontransportresponsetocAMP
3-phosphoinositide-dependent protein kinase 1
8.5
64
44
PDPK1PDPK1O15530O15530actincytoskeletonorganizationactivationofproteinkinaseBactivitycalcium-mediatedsignalingcellmigrationcellularresponsetoepidermalgrowthfactorstimuluscellularresponsetoinsulinstimulusepidermalgrowthfactorreceptorsignalingpathwayextrinsicapoptoticsignalingpathwayhyperosmoticresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwayintracellularsignaltransductionnegativeregulationofcardiacmusclecellapoptoticprocessnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofproteinkinaseactivitynegativeregulationoftoll-likereceptorsignalingpathwaynegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofphospholipaseactivitypositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofsproutingangiogenesispositiveregulationofvascularendothelialcellproliferationproteinautophosphorylationproteinphosphorylationregulationofI-kappaBkinase/NF-kappaBsignalingregulationofmastcelldegranulationtypeBpancreaticcelldevelopment
WD repeat-containing protein 91
8.5
66
43
WDR91WDR91A4D1P6A4D1P6earlyendosometolateendosometransportregulationofphosphatidylinositol3-kinaseactivityregulationofproteincatabolicprocess
ADP-ribose glycohydrolase OARD1
8.5
77
39
OARD1OARD1Q9Y530Q9Y530cellularresponsetoDNAdamagestimuluspeptidyl-glutamateADP-deribosylationproteinde-ADP-ribosylationpurinenucleosidemetabolicprocess
KN motif and ankyrin repeat domains 1
8.5
65
44
E9Q238E9Q238E9Q238E9Q238actincytoskeletonorganizationcellpopulationproliferationnegativeregulationofactinfilamentpolymerizationnegativeregulationofcellmigrationnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationoflamellipodiummorphogenesisnegativeregulationofneuronprojectiondevelopmentnegativeregulationofRhoproteinsignaltransductionnegativeregulationofruffleassemblynegativeregulationofsubstrateadhesion-dependentcellspreadingpodocytecellmigrationpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofWntsignalingpathwaypositiveregulationofwoundhealingregulationofestablishmentofcellpolarityregulationofRhoproteinsignaltransduction
Tumor necrosis factor receptor superfamily member 17
2.0
nan
90
TNR17TNR17Q02223Q02223adaptiveimmuneresponselymphocytehomeostasissignaltransductiontumornecrosisfactor-mediatedsignalingpathway
Retinol-binding protein 1
8.5
70
41
RET1RET1P09455P09455fattyacidtransportlipidhomeostasisretinoicacidbiosyntheticprocessvitaminAmetabolicprocess
Proteasome subunit alpha type-7
8.5
88
34
✔
PSA7PSA7Q9Z2U0Q9Z2U0proteasomalproteincatabolicprocessubiquitin-dependentproteincatabolicprocess
Dual specificity mitogen-activated protein kinase kinase 7
9.0
75
40
✔
MP2K7MP2K7O14733O14733apoptoticprocesscellularresponsetointerleukin-1cellularresponsetolipopolysaccharidecellularresponsetosorbitolcellularsenescenceFc-epsilonreceptorsignalingpathwayJNKcascadeMAPKcascadepositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofneuronapoptoticprocesspositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomeraseregulationofmotorneuronapoptoticprocessresponsetoheatresponsetoosmoticstressresponsetotumornecrosisfactorresponsetoUVresponsetowoundingsignaltransductionstress-activatedMAPKcascade
Dual specificity protein phosphatase 4
8.5
72
41
DUS4DUS4Q13115Q13115dephosphorylationendodermformationnegativeregulationofERK1andERK2cascadenegativeregulationofMAPKcascadeproteindephosphorylation
Maleylacetoacetate isomerase
8.5
92
35
MAAIMAAIO43708O43708glutathionemetabolicprocessL-phenylalaninecatabolicprocesstyrosinecatabolicprocess
Splicing factor U2AF 65 kDa subunit
6.3
81
49
✔
U2AF2U2AF2P26368P26368mRNAprocessingmRNAsplicingviaspliceosomenegativeregulationofmRNAsplicingviaspliceosomenegativeregulationofproteinubiquitinationpositiveregulationofRNAsplicing
Polyamine-modulated factor 1
4.9
54
72
✔
MIS12PMF1Q9H081Q6P1K2attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionchromosomesegregationkinetochoreassemblymitoticsisterchromatidsegregationproteinlocalizationtokinetochoretranscriptionbyRNApolymeraseII
Tyrosine-protein phosphatase non-receptor type 7
8.5
71
45
PTN7PTN7P35236P35236MAPKcascadeproteindephosphorylation
Inositol-trisphosphate 3-kinase B
8.5
63
44
IP3KBIP3KBP42335P42335cellsurfacereceptorsignalingpathwaycellularresponsetocalciumioncommonmyeloidprogenitorcellproliferationinositolphosphatebiosyntheticprocessinositoltrisphosphatemetabolicprocessMAPKcascademyeloidcellhomeostasisnegativeregulationofmyeloidcelldifferentiationnegativeregulationofneutrophilapoptoticprocessphosphatidylinositolphosphatebiosyntheticprocessphosphorylationpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofRasproteinsignaltransductionpositivethymicTcellselectionregulationofproteinphosphorylationTcelldifferentiationthymicTcellselection
Tumor necrosis factor receptor superfamily member 13C
2.0
55
85
TR13CTR13CQ96RJ3Q96RJ3adaptiveimmuneresponseBcellcostimulationpositiveregulationofBcellproliferationpositiveregulationofTcellproliferationTcellcostimulationtumornecrosisfactor-mediatedsignalingpathway
DNA ligase 1
8.5
77
32
DNLI1DNLI1P18858P18858anatomicalstructuremorphogenesisbase-excisionrepairbase-excisionrepairgap-fillingcelldivisionDNAbiosyntheticprocessDNAligationDNArecombinationDNArepairlaggingstrandelongationmismatchrepairOkazakifragmentprocessinginvolvedinmitoticDNAreplication
Transcriptional enhancer factor TEF-1
8.5
83
32
TEAD1TEAD1P28347P28347embryonicorgandevelopmenthipposignalingpositiveregulationofcellgrowthpositiveregulationofDNA-templatedtranscriptionpositiveregulationofmiRNAtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIprotein-containingcomplexassemblyregulationoftranscriptionbyRNApolymeraseII
Bifunctional purine biosynthesis protein ATIC
8.5
87
32
✔
PUR9PUR9P31939P31939"denovoAMPbiosyntheticprocess""denovoIMPbiosyntheticprocess""denovoXMPbiosyntheticprocess"animalorganregenerationbrainstemdevelopmentcellularresponsetointerleukin-7cerebellumdevelopmentcerebralcortexdevelopmentdihydrofolatemetabolicprocessGMPbiosyntheticprocessnucleobase-containingcompoundmetabolicprocessnucleosidemetabolicprocessresponsetoinorganicsubstancetetrahydrofolatebiosyntheticprocess
Ubiquitin thioesterase OTU1
8.5
83
34
OTU1OTU1Q5VVQ6Q5VVQ6endoplasmicreticulumunfoldedproteinresponsemacroautophagynegativeregulationofretrogradeproteintransportERtocytosolproteindeubiquitinationproteinK11-linkeddeubiquitinationproteinK27-linkeddeubiquitinationproteinK29-linkeddeubiquitinationproteinK33-linkeddeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitinationubiquitin-dependentERADpathway
Queuosine salvage protein
8.5
96
32
QSPPQSPPQ5T6V5Q5T6V5tRNAmodificationtRNA-guaninetransglycosylation
40S ribosomal protein S3a
8.5
71
40
Q6NXR8Q6NXR8Q6NXR8Q6NXR8celldifferentiationtranslation
Core-binding factor subunit beta
8.5
55
47
PEBBPEBBQ13951Q13951cellmaturationdefinitivehemopoiesislymphocytedifferentiationmyeloidcelldifferentiationnegativeregulationofCD4-positivealpha-betaTcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastdifferentiationpositiveregulationofCD8-positivealpha-betaTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinpolyubiquitinationregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
Cytosolic phospholipase A2
8.5
43
51
PA24APA24AP47712P47712arachidonicacidmetabolicprocessarachidonicacidsecretioncellularresponsetoantibioticestablishmentoflocalizationincellglycerolmetabolicprocessglycerophospholipidcatabolicprocessicosanoidmetabolicprocessleukotrienebiosyntheticprocessmonoacylglycerolbiosyntheticprocessphosphatidylcholineacyl-chainremodelingphosphatidylcholinecatabolicprocessphosphatidylglycerolcatabolicprocessplateletactivatingfactorbiosyntheticprocesspositiveregulationofmacrophageactivationpositiveregulationofplateletactivationpositiveregulationofprostaglandinsecretionpositiveregulationofT-helper1typeimmuneresponseprostaglandinbiosyntheticprocessregulationofcellpopulationproliferation
Cyclin-dependent kinase 12
8.5
71
36
CDK12CDK12Q9NYV4Q9NYV4mRNAprocessingnegativeregulationofstemcelldifferentiationphosphorylationofRNApolymeraseIIC-terminaldomainpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinautophosphorylationproteinphosphorylationregulationofMAPkinaseactivityregulationofRNAsplicingRNAsplicingtranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoter
Chromosome 1 open reading frame 57, isoform CRA_d
8.5
57
45
Q5TDE9Q5TDE9Q5TDE9Q5TDE9
DNA excision repair protein ERCC-6-like 2
8.5
58
47
ER6L2ER6L2Q5T890Q5T890cellularresponsetoreactiveoxygenspeciesinterstrandcross-linkrepair
Receptor-type tyrosine-protein phosphatase R
9.3
74
40
PTPRRPTPRRQ62132Q62132ERBB2signalingpathwayinuteroembryonicdevelopmentnegativeregulationofepithelialcellmigrationnegativeregulationofERK1andERK2cascadepeptidyl-tyrosinedephosphorylationproteindephosphorylationsignaltransduction
Phospholemman
8.5
50
49
PLMPLMO00168O00168chloridetransportmusclecontractionnegativeregulationofproteinglutathionylationpositiveregulationofsodiumionexportacrossplasmamembranepotassiumiontransportregulationofcardiacmusclecellmembranepotentialregulationofheartcontractionregulationofsodiumiontransmembranetransporteractivitysodiumiontransport
Serine/threonine-protein kinase LMTK3
8.5
60
46
LMTK3LMTK3Q96Q04Q96Q04proteinphosphorylation
Glutamate receptor ionotropic, NMDA 3B
2.1
56
84
NMD3BNMD3BQ8VHN2Q8VHN2calciumiontransmembranetransportionotropicglutamatereceptorsignalingpathwayproteininsertionintomembraneregulationofcalciumiontransport
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
4.4
75
78
HCN1HCN1O60741O60741apicalproteinlocalizationcellularresponsetocAMPgeneraladaptationsyndromebehavioralprocessnegativeregulationofsynaptictransmissionglutamatergicneuronalactionpotentialpotassiumiontransmembranetransportproteinhomotetramerizationregulationofcationchannelactivityregulationofheartratebycardiacconductionregulationofmembranedepolarizationregulationofmembranepotentialregulationofSAnodecellactionpotentialretinalconecelldevelopmentsodiumiontransmembranetransport
Synembryn-A
8.5
65
41
RIC8AGNAT2Q5E9J8P19087adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaybasementmembraneorganizationcellmigrationinvolvedingastrulationcell-celladhesioninvolvedingastrulationGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentvasculaturedevelopmentvisuallearningadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaydetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertastedetectionoflightstimulusinvolvedinvisualperceptionphototransductionpositiveregulationofcytosoliccalciumionconcentrationresponsetolightintensityretinalconecelldevelopmentvisualperception
TEA domain transcription factor 1
8.6
78
34
E9PKB7E9PKB7E9PKB7E9PKB7
Serine/arginine-rich splicing factor 3
9.2
48
48
SRSF3SRSF3P84103P84103cellularresponsetoleukemiainhibitoryfactormRNAexportfromnucleusmRNAsplicingviaspliceosomeprimarymiRNAprocessingregulationofmRNAsplicingviaspliceosome
Toll-like receptor 10
8.6
61
37
TLR10TLR10Q9BXR5Q9BXR5immuneresponseinflammatoryresponseinnateimmuneresponsetoll-likereceptorsignalingpathway
Acyl-protein thioesterase 1
8.6
54
43
LYPA1LYPA1O75608O75608fattyacidmetabolicprocessnegativeregulationofGolgitoplasmamembraneproteintransportproteindepalmitoylation
Polycomb protein SCMH1
9.6
68
39
SCMH1SCMH1Q96GD3Q96GD3heterochromatinformationnegativeregulationofDNA-templatedtranscription
Presequence protease, mitochondrial
3.7
51
74
PREPPREPQ5JRX3Q5JRX3proteinprocessingproteintargetingtomitochondrionproteolysis
Structural maintenance of chromosomes flexible hinge domain-containing protein 1
3.5
51
81
SMHD1SMHD1Q6P5D8Q6P5D8chromosomeorganizationdosagecompensationbyinactivationofXchromosomedouble-strandbreakrepairinactivationofXchromosomebyheterochromatinformationnegativeregulationofdouble-strandbreakrepairviahomologousrecombinationnosedevelopmentpositiveregulationofDNArepairpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoining
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
8.9
57
47
ANS1BANS1BQ7Z6G8Q7Z6G8ephrinreceptorsignalingpathway
Calcium/calmodulin-dependent protein kinase type II subunit delta
9.3
77
29
KCC2DKCC2DQ6PHZ2Q6PHZ2calciumiontransportcardiacmusclecellcontractioncardiacmusclecontractioncellgrowthinvolvedincardiacmusclecelldevelopmentcellularpotassiumionhomeostasisendoplasmicreticulumcalciumionhomeostasisG1/Stransitionofmitoticcellcyclenegativeregulationofsodiumiontransmembranetransportnegativeregulationofsodiumiontransmembranetransporteractivitypeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofcardiacmusclehypertrophypositiveregulationofDNAbiosyntheticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofG2/MtransitionofmitoticcellcyclepositiveregulationofRacproteinsignaltransductionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofvascularassociatedsmoothmusclecellproliferationproteinautophosphorylationproteinphosphorylationregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofcardiacmusclecellactionpotentialregulationofcellcommunicationbyelectricalcouplingregulationofcellularlocalizationregulationofmembranedepolarizationregulationofproteinlocalizationtoplasmamembraneregulationofrelaxationofcardiacmuscleregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumregulationofsodiumiontransportrelaxationofcardiacmuscleresponsetohypoxia
Sulfotransferase 1C4
8.6
69
43
ST1C4ST1C4O75897O75897"3-phosphoadenosine5-phosphosulfatemetabolicprocess"doxorubicinmetabolicprocessethanolcatabolicprocessflavonoidmetabolicprocesssulfationxenobioticmetabolicprocess
Bromodomain and WD repeat-containing protein 1
8.6
71
44
BRWD1BRWD1Q9NSI6Q9NSI6cytoskeletonorganizationregulationofcellshaperegulationoftranscriptionbyRNApolymeraseII
Regulator of G-protein signaling 1
8.6
67
43
RGS1RGS1Q08116Q08116adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayimmuneresponseleukotrienesignalingpathwaynegativeregulationofsignaltransductionpositiveregulationofGTPaseactivityresponsetobacteriumsignaltransduction
Ataxin-3
9.5
75
34
ATX3ATX3P54252P54252actincytoskeletonorganizationcellularresponsetoheatcellularresponsetomisfoldedproteinchemicalsynaptictransmissionexplorationbehaviorintermediatefilamentcytoskeletonorganizationmicrotubulecytoskeletonorganizationmonoubiquitinatedproteindeubiquitinationnervoussystemdevelopmentnucleotide-excisionrepairpositiveregulationofERADpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitinationproteinlocalizationtocytosolicproteasomecomplexinvolvedinERADpathwayproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsregulationofcell-substrateadhesionubiquitin-dependentproteincatabolicprocess
Nucleus accumbens-associated protein 1
9.0
44
46
✔
NACC1NACC1Q96RE7Q96RE7negativeregulationofDNA-templatedtranscriptionpositiveregulationofcellpopulationproliferationregulationoftranscriptionbyRNApolymeraseII
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
8.6
43
53
✔
NFU1NFU1Q9UMS0Q9UMS0iron-sulfurclusterassemblyproteinmaturationbyiron-sulfurclustertransfer
Renalase
6.5
52
59
RNLSRNLSQ5VYX0Q5VYX0negativeregulationofbloodpressurenegativeregulationofheartrateresponsetoepinephrineresponsetoischemiaresponsetosalt
NLR family member X1
8.6
68
46
NLRX1NLRX1Q86UT6Q86UT6innateimmuneresponseintracellularsignaltransductionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinnateimmuneresponsenegativeregulationofinterferon-betaproductionnegativeregulationofinterleukin-6productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofRIG-Isignalingpathway
TBC1 domain family member 7
8.6
80
41
TBCD7TBCD7Q9P0N9Q9P0N9activationofGTPaseactivitynegativeregulationofciliumassemblynegativeregulationofTORsignalingpositiveregulationofGTPaseactivitypositiveregulationofproteinubiquitinationresponsetogrowthfactor
SHC-transforming protein 1
8.7
60
47
SHC1SHC1P29353P29353actincytoskeletonreorganizationangiogenesiscell-celladhesioncellularresponsetogrowthfactorstimulusdefenseresponsetobacteriumepidermalgrowthfactorreceptorsignalingpathwayheartdevelopmentinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwayintracellularsignaltransductionnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofDNA-templatedtranscriptionpositiveregulationofcellpopulationproliferationpositiveregulationofcellproliferationinbonemarrowpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofMAPKcascaderegulationofepidermalgrowthfactor-activatedreceptoractivityregulationofsuperoxidemetabolicprocesstransmembranereceptorproteintyrosinekinasesignalingpathway
Ubiquitin carboxyl-terminal hydrolase 25
8.6
65
39
UBP25UBP25Q9UHP3Q9UHP3negativeregulationofERADpathwayproteindeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitinationproteinmodificationprocessproteolysisubiquitin-dependentproteincatabolicprocess
Exosome RNA helicase MTR4
9.8
65
36
MTREXMTREXP42285P42285cellularresponsetoDNAdamagestimulusmaturationof5.8SrRNAmRNAsplicingviaspliceosomeRNAcatabolicprocessrRNAprocessingsnRNAcatabolicprocess
Dipeptidyl peptidase 9
8.6
73
42
M0R781M0R781M0R781M0R781proteolysispyroptosis
Transient receptor potential cation channel subfamily A member 1
5.0
43
70
TRPA1TRPA1O75762O75762calciumiontransmembranetransportcellsurfacereceptorsignalingpathwaycellularcalciumionhomeostasiscellularresponsetohydrogenperoxidecellularresponsetoorganicsubstancedetectionofchemicalstimulusinvolvedinsensoryperceptionofpaindetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainiontransportproteinhomotetramerizationresponsetocoldresponsetoorganiccycliccompoundresponsetoorganicsubstanceresponsetopainresponsetoxenobioticstimulussensoryperceptionofpainthermoception
Fibroblast growth factor 1
5.1
79
61
FGF1FGF1P05230P05230activationofproteinkinaseBactivityanatomicalstructuremorphogenesisangiogenesisanimalorganmorphogenesisbranchelongationinvolvedinuretericbudbranchingcelldifferentiationcellularresponsetoheatepithelialcellproliferationfibroblastgrowthfactorreceptorsignalingpathwaylungdevelopmentmesonephricepitheliumdevelopmentorganinductionpositiveregulationofangiogenesispositiveregulationofcelldivisionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcholesterolbiosyntheticprocesspositiveregulationofendothelialcellmigrationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofhepatocyteproliferationpositiveregulationofintracellularsignaltransductionpositiveregulationofMAPkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellmigrationregulationofendothelialcellchemotaxistofibroblastgrowthfactorregulationofendothelialtubemorphogenesissignaltransductionwoundhealing
ATP-dependent DNA helicase PIF1
8.6
62
45
PIF1PIF1Q9H611Q9H611DNAduplexunwindingDNArecombinationDNArepairDNAreplicationmitochondrialgenomemaintenancenegativeregulationoftelomeraseactivitynegativeregulationoftelomeremaintenanceviatelomeraseregulationoftelomeremaintenancetelomeremaintenanceviatelomerase
ATP-binding cassette sub-family C member 9
2.0
68
82
ABCC9ABCC9Q63563Q63563cardiacconductioncardiacmusclecellcontractioncationtransmembranetransportdefenseresponsetovirusinorganiccationtransmembranetransportnegativeregulationofbloodpressurepotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportregulationofvoltage-gatedpotassiumchannelactivityinvolvedinventricularcardiacmusclecellactionpotentialrepolarizationresponsetoATPresponsetoxenobioticstimulussubstrate-dependentcellmigrationcellcontractiontransmembranetransport
Splicing regulator SDE2
8.6
47
50
✔
SDE2SDE2Q6IQ49Q6IQ49celldivisioncellularresponsetoUVDNAreplicationendonucleolyticcleavageoftricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)mitoticG1DNAdamagecheckpointsignalingmRNAcissplicingviaspliceosomeproteinprocessingproteinubiquitination
Deubiquitinase MYSM1
8.6
54
50
✔
MYSM1MYSM1Q5VVJ2Q5VVJ2chromatinremodelingimmunesystemprocessmonoubiquitinatedhistoneH2AdeubiquitinationpigmentationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellmigrationregulationofhairfollicledevelopmentregulationofhemopoiesis
DNA-directed RNA polymerase III subunit RPC8
9.8
83
35
RPC8RPC8Q9Y535Q9Y535defenseresponsetovirusinnateimmuneresponsenucleobase-containingcompoundmetabolicprocesstranscriptionbyRNApolymeraseIIItranscriptioninitiationatRNApolymeraseIIIpromoter
NEDD8-conjugating enzyme Ubc12
8.6
58
45
UBC12UBC12P61081P61081positiveregulationofneuronapoptoticprocesspost-translationalproteinmodificationproteinmodificationprocessproteinneddylation
Polycystin-2
8.6
62
44
PKD2PKD2Q13563Q13563aortadevelopmentbranchinginvolvedinuretericbudmorphogenesiscalciumiontransmembranetransportcalciumiontransportcell-cellsignalingbywntcellularcalciumionhomeostasiscellularresponsetocalciumioncellularresponsetocAMPcellularresponsetofluidshearstresscellularresponsetohydrostaticpressurecellularresponsetoosmoticstresscellularresponsetoreactiveoxygenspeciescentrosomeduplicationciliumorganizationcytoplasmicsequesteringoftranscriptionfactordetectionofmechanicalstimulusdetectionofnodalflowdeterminationofleft/rightsymmetrydeterminationofliverleft/rightasymmetryembryonicplacentadevelopmentestablishmentoflocalizationincellheartdevelopmentheartloopinginorganiccationtransmembranetransportliverdevelopmentmesonephricductdevelopmentmesonephrictubuledevelopmentmetanephricascendingthinlimbdevelopmentmetanephriccortexdevelopmentmetanephriccorticalcollectingductdevelopmentmetanephricdistaltubuledevelopmentmetanephricmesenchymedevelopmentmetanephricpartofuretericbuddevelopmentmetanephricS-shapedbodymorphogenesismetanephricsmoothmuscletissuedevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofryanodine-sensitivecalcium-releasechannelactivityneuraltubedevelopmentplacentabloodvesseldevelopmentpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofgeneexpressionpositiveregulationofinositol145-trisphosphate-sensitivecalcium-releasechannelactivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIpotassiumiontransmembranetransportproteinheterotetramerizationproteinhomotetramerizationproteintetramerizationreceptorsignalingpathwayviaJAK-STATregulationofcalciumionimportregulationofcellcycleregulationofcellpopulationproliferationreleaseofsequesteredcalciumionintocytosolrenalarterymorphogenesisrenaltubulemorphogenesissodiumiontransmembranetransportspinalcorddevelopmentWntsignalingpathway
Bleomycin hydrolase
9.4
55
41
BLMHBLMHQ13867Q13867homocysteinecatabolicprocessproteinpolyubiquitinationproteolysisresponsetotoxicsubstanceresponsetoxenobioticstimulus
FAS-associated factor 1
8.6
47
49
FAF1FAF1Q9UNN5Q9UNN5apoptoticprocesscelldeathcytoplasmicsequesteringofNF-kappaBpositiveregulationofapoptoticprocesspositiveregulationofcelldeathpositiveregulationofDNAreplicationpositiveregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofproteincatabolicprocesspositiveregulationofprotein-containingcomplexassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofcelladhesionregulationofproteincatabolicprocessubiquitin-dependentERADpathway
Interleukin-1 receptor antagonist protein
8.6
59
46
IL1RAIL1RAP18510P18510acute-phaseresponseimmuneresponseinflammatoryresponseinflammatoryresponsetoantigenicstimulusinsulinsecretionlipidmetabolicprocessnegativeregulationofheterotypiccell-celladhesionnegativeregulationofinterleukin-1-mediatedsignalingpathwayresponsetoglucocorticoid
Kappa-type opioid receptor
2.0
64
85
OPRKOPRKP41145P41145adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingopioidreceptorsignalingpathwaybehavioralresponsetococainecellularresponsetoglucosestimuluscellularresponsetolipopolysaccharidechemicalsynaptictransmissionconditionedplacepreferencedefenseresponsetoviruseatingbehaviorestrouscycleGprotein-coupledopioidreceptorsignalingpathwayimmuneresponselocomotorybehaviormaternalbehaviornegativeregulationofluteinizinghormonesecretionneuropeptidesignalingpathwayphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofdopaminesecretionpositiveregulationofeatingbehaviorpositiveregulationoflocomotionpositiveregulationofp38MAPKcascadepositiveregulationofpotassiumiontransmembranetransportregulationofsalivasecretionregulationofsensoryperceptionofpainresponsetoacrylamideresponsetoestrogenresponsetoethanolresponsetoinsulinresponsetomorphineresponsetoradiationsensoryperceptionsensoryperceptionofpainsensoryperceptionoftemperaturestimulus
Suppressor of cytokine signaling 3
8.6
nan
53
SOCS3ELOCO35718P83940branchinginvolvedinlabyrinthinelayermorphogenesiscelldifferentiationcellularresponsetointerleukin-17cellularresponsetoleukemiainhibitoryfactorintracellularsignaltransductionnegativeregulationofinflammatoryresponsenegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofsignaltransductionnegativeregulationoftyrosinephosphorylationofSTATproteinphosphatidylinositolphosphatebiosyntheticprocessplacentabloodvesseldevelopmentpositiveregulationofcelldifferentiationproteinubiquitinationreceptorsignalingpathwayviaJAK-STATregulationofproteinphosphorylationsignaltransductiontranscriptioninitiationatRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocess
Glutathione synthetase
8.6
78
37
✔
GSHBGSHBP48637P48637aminoacidmetabolicprocessnervoussystemdevelopmentresponsetocadmiumionresponsetooxidativestress
Fascin
5.7
77
58
✔
FSCN1FSCN1Q16658Q16658actincytoskeletonorganizationactinfilamentbundleassemblycellmigrationcellmotilitycell-celljunctionassemblyestablishmentofapical/basalcellpolarityestablishmentormaintenanceofcellpolaritymicrospikeassemblyparallelactinfilamentbundleassemblypositiveregulationofextracellularmatrixdisassemblypositiveregulationoffilopodiumassemblypositiveregulationoflamellipodiumassemblypositiveregulationofpodosomeassemblyregulationofactincytoskeletonorganizationregulationofmicrovillusassembly
Proteasome (Prosome, macropain) 26S subunit, ATPase 3
9.5
83
36
PSA1Q6P6U2P18420Q6P6U2immunesystemprocessnegativeregulationofinflammatoryresponsetoantigenicstimulusproteasomalproteincatabolicprocessubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
Apelin receptor
2.0
52
85
APJAPJP35414P35414adultheartdevelopmentangiogenesisaortadevelopmentapelinreceptorsignalingpathwayatrioventricularvalvedevelopmentbloodvesseldevelopmentcoronaryvasculaturedevelopmentendocardialcushionformationGprotein-coupledreceptorsignalingpathwaygastrulationheartdevelopmentheartloopingnegativeregulationofcAMP-mediatedsignalingnegativeregulationofgeneexpressionpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesispositiveregulationofhistonedeacetylationpositiveregulationofinhibitoryGprotein-coupledreceptorphosphorylationpositiveregulationofreleaseofsequesteredcalciumionintocytosolregulationofbodyfluidlevelsregulationofgapjunctionassemblyregulationofgeneexpressionvascularassociatedsmoothmusclecelldifferentiationvasculaturedevelopmentvasculogenesisvenousbloodvesseldevelopmentventricularseptummorphogenesis
Serine/threonine-protein kinase D2
8.6
56
46
KPCD2KPCD2Q9BZL6Q9BZL6adaptiveimmuneresponseangiogenesiscelladhesioncellularresponsetovascularendothelialgrowthfactorstimulusendothelialtubemorphogenesisintracellularsignaltransductionpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcelladhesionpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendothelialcellchemotaxispositiveregulationofendothelialcellchemotaxisbyVEGF-activatedvascularendothelialgrowthfactorreceptorsignalingpathwaypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofhistonedeacetylaseactivitypositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-8productionpositiveregulationofintracellularsignaltransductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofTcellreceptorsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayproteinautophosphorylationproteinkinaseDsignalingproteinphosphorylationregulationofTcellapoptoticprocesssphingolipidbiosyntheticprocessTcellreceptorsignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
Cytochrome b-c1 complex subunit 1, mitochondrial
5.6
74
53
QCR1QCR1Q9CZ13Q9CZ13cellularrespirationmitochondrialelectrontransportubiquinoltocytochromecmitochondrialrespiratorychaincomplexIIIassemblyresponsetoactivityresponsetoalkaloid
39S ribosomal protein L22, mitochondrial
8.6
50
48
RM22RM22Q9NWU5Q9NWU5mitochondrialtranslationribosomeassembly
Neuronal PAS domain protein 4
8.6
75
34
A1L327A1L327A1L327A1L327regulationofDNA-templatedtranscription
Mitochondrial ribosomal protein L39
9.1
63
41
F1SHP6F1SHP6F1SHP6F1SHP6translation
Solute carrier family 40 member 1
2.0
49
86
S40A1S40A1Q9NP59Q9NP59apoptoticprocesscellularironionhomeostasisendotheliumdevelopmentestablishmentoflocalizationincellironionexportacrossplasmamembraneironionhomeostasisironiontransmembranetransportlymphocytehomeostasismulticellularorganismalironionhomeostasisnegativeregulationofapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoironspleentrabeculaformationtranscriptionbyRNApolymeraseII
ER membrane protein complex subunit 8
8.7
78
38
EMC8EMC8O43402O43402proteininsertionintoERmembranebystop-transfermembrane-anchorsequencetail-anchoredmembraneproteininsertionintoERmembrane
TBC1 domain family member 4
8.7
34
52
TBCD4TBCD4O60343O60343activationofGTPaseactivitycellularresponsetoinsulinstimulusnegativeregulationofvesiclefusionvesicle-mediatedtransport
BRISC and BRCA1-A complex member 2
8.7
74
38
BABA2BABA2Q9NXR7Q9NXR7apoptoticprocesscelldivisioncellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationchromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointnegativeregulationofapoptoticprocesspositiveregulationofDNArepairproteinautoubiquitinationproteinK63-linkeddeubiquitinationregulationofDNAdamagecheckpointregulationofDNArepairresponsetoionizingradiationsignaltransduction
ATP-dependent RNA helicase DHX15
9.2
64
41
DHX15DHX15O43143O43143antiviralinnateimmuneresponsedefenseresponsetobacteriumdefenseresponsetovirusmRNAprocessingpositiveregulationofI-kappaBkinase/NF-kappaBsignalingresponsetoalkaloidresponsetotoxicsubstanceRNAsplicing
40S ribosomal protein S3a
8.7
70
41
✔
RS3ARS3AP61247P61247celldifferentiationcytoplasmictranslationnegativeregulationofapoptoticprocesstranslationtranslationalinitiation
Serine/threonine-protein kinase Nek7
8.7
76
36
NEK7NEK7Q8TDX7Q8TDX7cellularresponsetopotassiumionpeptidyl-serinephosphorylationpositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomeraseproteinphosphorylationregulationofmitoticcellcyclespindleassembly
ATP-binding cassette sub-family C member 8
3.8
71
69
ABCC8ABCC8Q09428Q09428cellularglucosehomeostasiscellularresponsetoorganicsubstancefemalepregnancyinorganiccationtransmembranetransportmemorynegativeregulationofangiogenesisnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofglialcellproliferationnegativeregulationofinsulinsecretionnegativeregulationoflow-densitylipoproteinparticleclearancenegativeregulationofneuroblastmigrationnegativeregulationofwoundhealingpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationoftightjunctiondisassemblypositiveregulationoftumornecrosisfactorproductionpositiveregulationofuterinesmoothmusclerelaxationpositiveregulationofvoltage-gatedpotassiumchannelactivitypotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportresponsetoinsulinresponsetolipopolysaccharideresponsetopHresponsetoxenobioticstimulusresponsetozinciontransmembranetransportvisuallearning
Interferon-induced protein with tetratricopeptide repeats 1
8.7
54
42
IFIT1IFIT1P09914P09914antiviralinnateimmuneresponsecellularresponsetoexogenousdsRNAcellularresponsetotypeIinterferondefenseresponsetovirusintracellulartransportofviralproteininhostcellnegativeregulationofhelicaseactivitynegativeregulationofproteinbindingnegativeregulationofviralgenomereplicationpositiveregulationofviralgenomereplicationresponsetovirus
Tumor susceptibility gene 101 protein
8.7
65
40
TS101TS101Q99816Q99816autophagosomematurationcellcyclecelldivisionendosometolysosometransportexosomalsecretionextracellulartransportkeratinocytedifferentiationmacroautophagymembranefissionmultivesicularbodyassemblynegativeregulationofcellpopulationproliferationnegativeregulationofepidermalgrowthfactorreceptorsignalingpathwaynegativeregulationofepidermalgrowthfactor-activatedreceptoractivitynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofexosomalsecretionpositiveregulationofubiquitin-dependentendocytosispositiveregulationofviralbuddingviahostESCRTcomplexproteinmonoubiquitinationproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayregulationofcellcycleregulationofcellgrowthregulationofextracellularexosomeassemblyregulationofMAPkinaseactivityubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayviralbuddingviralbuddingviahostESCRTcomplexviralreleasefromhostcell
Pumilio homolog 1
8.7
79
40
PUM1PUM1Q14671Q14671adultlocomotorybehaviormiRNAprocessingmRNAdestabilizationpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofRIG-Isignalingpathwaypost-transcriptionalgenesilencingpost-transcriptionalregulationofgeneexpressionregulationofcellcycleregulationofchromosomesegregationregulationofmiRNA-mediatedgenesilencingregulationofmRNAstabilityspermatogenesisstemcelldifferentiation
MBT domain-containing protein 1
8.7
79
41
MBTD1MBTD1Q05BQ5Q05BQ5chromatinorganizationdouble-strandbreakrepairviahomologousrecombinationembryonicskeletalsystemdevelopmenthistoneacetylationhistoneH2AacetylationhistoneH4acetylationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofapoptoticprocessregulationofcellcycleregulationofdouble-strandbreakrepair
Elongation factor 1-alpha 2
8.7
73
39
EF1A2EF1A2Q05639Q05639positiveregulationofapoptoticprocesspositiveregulationoflipidkinaseactivityregulationofchaperone-mediatedautophagytranslationtranslationalelongation
Isocitrate dehydrogenase [NADP], mitochondrial
8.8
74
37
IDHPIDHPP48735P487352-oxoglutaratemetabolicprocesscarbohydratemetabolicprocessglyoxylatecycleisocitratemetabolicprocessNADPmetabolicprocesstricarboxylicacidcycle
Proteinase-activated receptor 2
2.0
70
83
PAR2PAR2P55085P55085bloodcoagulationcell-celljunctionmaintenancedefenseresponsetovirusestablishmentofendothelialbarrierGprotein-coupledreceptorsignalingpathwayinflammatoryresponseinnateimmuneresponseleukocytemigrationleukocyteproliferationmatureconventionaldendriticcelldifferentiationnegativeregulationofchemokineproductionnegativeregulationofinsulinsecretionnegativeregulationofJNKcascadenegativeregulationoftoll-likereceptor3signalingpathwaynegativeregulationoftumornecrosisfactor-mediatedsignalingpathwayneutrophilactivationpositiveregulationofactinfilamentdepolymerizationpositiveregulationofcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemotaxispositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwaypositiveregulationofeosinophildegranulationpositiveregulationofERK1andERK2cascadepositiveregulationofglomerularfiltrationpositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofleukocytechemotaxispositiveregulationofneutrophilmediatedkillingofgram-negativebacteriumpositiveregulationofphagocytosisengulfmentpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofpositivechemotaxispositiveregulationofpseudopodiumassemblypositiveregulationofreninsecretionintobloodstreampositiveregulationofRhoproteinsignaltransductionpositiveregulationofsuperoxideaniongenerationpositiveregulationoftoll-likereceptor2signalingpathwaypositiveregulationoftoll-likereceptor3signalingpathwaypositiveregulationoftoll-likereceptor4signalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionregulationofbloodcoagulationregulationofchemokine(C-X-Cmotif)ligand2productionregulationofI-kappaBkinase/NF-kappaBsignalingregulationofJNKcascadeTcellactivationinvolvedinimmuneresponsevasodilation
Serine/threonine-protein kinase PRP4 homolog
7.8
69
45
PRP4BPRP4BQ13523Q13523mRNAcissplicingviaspliceosomemRNAsplicingviaspliceosomeproteinphosphorylationRNAsplicing
Protein-cysteine N-palmitoyltransferase HHAT
8.7
57
41
HHATHHATQ5VTY9Q5VTY9N-terminalpeptidyl-L-cysteineN-palmitoylationproteinpalmitoylationsmoothenedsignalingpathway
Solute carrier family 10 (Sodium/bile acid cotransporter family), member 1
2.0
80
80
Q2KJ85Q2KJ85Q2KJ85Q2KJ85bileacidandbilesalttransport
Signal recognition particle 9 kDa protein
8.7
55
39
✔
SRP09SRP09P49458P49458negativeregulationoftranslationalelongationSRP-dependentcotranslationalproteintargetingtomembrane
Pleckstrin homology domain-containing family A member 7
8.7
87
30
PKHA7PKHA7Q6IQ23Q6IQ23cell-celladhesionmediatedbycadherinepithelialcell-celladhesionporecomplexassemblyzonulaadherensmaintenance
Pyruvate kinase PKM
8.7
63
42
✔
KPYMKPYMP14618P14618canonicalglycolysiscellularresponsetoinsulinstimulusglycolyticprocesspositiveregulationofcytoplasmictranslationpositiveregulationofsproutingangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIIprogrammedcelldeath
Receptor-type tyrosine-protein phosphatase T
9.4
nan
49
PTPRTPTPRTO14522O14522celladhesioncellularresponsetointerleukin-6homophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofcellmigrationnegativeregulationofreceptorsignalingpathwayviaSTATpeptidyl-tyrosinedephosphorylationpeptidyl-tyrosinedephosphorylationinvolvedininactivationofproteinkinaseactivityproteindephosphorylationsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
F-actin-capping protein subunit alpha-1
8.7
87
33
CAZA1CAZA1A0PFK5A0PFK5actincytoskeletonorganizationbarbed-endactinfilamentcapping
Electron transfer flavoprotein subunit alpha, mitochondrial
8.9
83
40
ETFAETFAP13804P13804aminoacidcatabolicprocessfattyacidbeta-oxidationusingacyl-CoAdehydrogenaserespiratoryelectrontransportchain
StAR-related lipid transfer protein 5
6.0
84
48
STAR5STAR5Q9NSY2Q9NSY2cholesterolimport
40S ribosomal protein SA
8.7
92
32
G1TLT8G1TLT8G1TLT8G1TLT8ribosomalsmallsubunitassemblytranslation
28S ribosomal protein S35, mitochondrial
8.7
72
39
RT35RT35P82673P82673mitochondrialtranslation
Docking protein 2
8.7
42
53
DOK2DOK2Q8N5A4Q8N5A4cellsurfacereceptorsignalingpathwayRasproteinsignaltransductionsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
39S ribosomal protein L42, mitochondrial
8.7
78
36
✔
RM42RM42Q9Y6G3Q9Y6G3mitochondrialtranslationtranslation
AP-2 complex subunit mu
8.7
59
41
✔
AP2M1AP2M1P84092P84092clathrin-dependentendocytosisendocytosisintracellularproteintransportnegativeregulationofproteinlocalizationtoplasmamembranepositiveregulationofreceptorinternalizationpositiveregulationofsynapticvesicleendocytosispostsynapticneurotransmitterreceptorinternalizationprotein-containingcomplexassemblyreceptorinternalizationregulationofvesiclesizesynapticvesicleendocytosisvesiclebuddingfrommembranevesicle-mediatedtransport
Excitatory amino acid transporter 3
8.7
82
33
EAA3EAA3P43005P43005activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofproteinkinaseBactivityadultbehaviorbehavioralfearresponsebloodvesselmorphogenesisbraindevelopmentcellularglutamatehomeostasiscellularresponsetoammoniumioncellularresponsetobisphenolAcellularresponsetococainecellularresponsetomercuryioncellularresponsetoorganiccycliccompoundcellularzincionhomeostasischemicalsynaptictransmissionchloridetransmembranetransportconditionedplacepreferencecysteinetransportcytokine-mediatedsignalingpathwayD-aspartateimportacrossplasmamembraneD-aspartatetransportdopaminemetabolicprocessdopaminereceptorsignalingpathwaygeneexpressionglutamatereceptorsignalingpathwayglutathionebiosyntheticprocessgroomingbehaviorheartcontractioniontransportL-aspartateimportacrossplasmamembraneL-aspartatetransmembranetransportL-glutamateimportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportlocomotorybehaviorlong-termsynapticpotentiationmaintenanceofblood-brainbarriermemorymotorbehaviormotorneuronapoptoticprocessnegativeregulationofneuronapoptoticprocessneurogenesisneurondeathinresponsetooxidativestressneurotransmitterreceptortransporttoplasmamembraneneurotransmittertransportpeptidyl-serinephosphorylationpositiveregulationofheartratepostsynapticmodulationofchemicalsynaptictransmissionregulationofproteintargetingtomembraneresponsetoamphetamineresponsetoanestheticresponsetoaxoninjuryresponsetodecreasedoxygenlevelsresponsetomorphineresponsetoxenobioticstimulusretinalayerformationrightingreflexsuperoxidemetabolicprocesssynapseorganizationtransepithelialtransporttransportacrossblood-brainbarrierzinciontransmembranetransport
Dynein assembly factor with WDR repeat domains 1
8.7
76
42
DAW1DAW1Q8N136Q8N136cerebrospinalfluidcirculationdeterminationofleft/rightsymmetryestablishmentoflocalizationincellheartdevelopmentouterdyneinarmassemblyproteinpolyubiquitination
WD repeat-containing protein 55
8.7
43
45
WDR55WDR55Q9H6Y2Q9H6Y2rRNAprocessing
Translation initiation factor eIF-2B subunit delta
3.6
67
86
EI2BBEI2BDP49770Q9UI10centralnervoussystemdevelopmentmyelinationoligodendrocytedevelopmentovarianfollicledevelopmentregulationoftranslationalinitiationresponsetoglucoseresponsetoheatresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiationregulationoftranslation
Signal transducer and activator of transcription 2
8.7
75
35
STAT2STAT2P52630P52630cytokine-mediatedsignalingpathwaydefenseresponsedefenseresponsetovirusnegativeregulationoftypeIinterferon-mediatedsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIreceptorsignalingpathwayviaJAK-STATregulationofcellpopulationproliferationregulationofmitochondrialfissionregulationofproteinphosphorylationregulationoftranscriptionbyRNApolymeraseIIresponsetopeptidehormonetypeIinterferon-mediatedsignalingpathway
Regulator of G-protein signaling 2
8.7
66
43
RGS2RGS2P41220P41220braindevelopmentbrownfatcelldifferentiationcellcycleGprotein-coupledreceptorsignalingpathwaymaternalprocessinvolvedinfemalepregnancynegativeregulationofadenylatecyclase-inhibitingadrenergicreceptorsignalingpathwayinvolvedinheartprocessnegativeregulationofcardiacmusclehypertrophynegativeregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglycineimportacrossplasmamembranenegativeregulationofMAPkinaseactivitynegativeregulationofphospholipaseactivitynegativeregulationoftranslationovulationpositiveregulationofcardiacmusclecontractionpositiveregulationofneuronprojectiondevelopmentregulationofGprotein-coupledreceptorsignalingpathwayrelaxationofcardiacmusclerelaxationofvascularassociatedsmoothmuscleresponsetoamphetamineresponsetoethanolspermatogenesis
Choline-phosphate cytidylyltransferase A
8.7
107
27
PCY1APCY1AP19836P19836CDP-cholinepathwayphosphatidylcholinebiosyntheticprocess
Translation initiation factor eIF-2B subunit epsilon
9.2
71
40
EI2BEEI2BEQ13144Q13144agingastrocytedevelopmentastrocytedifferentiationhippocampusdevelopmentmyelinationoligodendrocytedevelopmentovarianfollicledevelopmentpositiveregulationofapoptoticprocesspositiveregulationoftranslationalinitiationresponsetoendoplasmicreticulumstressresponsetoglucoseresponsetoheatresponsetolithiumionresponsetopeptidehormoneTcellreceptorsignalingpathwaytranslationalinitiation
Nucleolar RNA helicase 2
8.7
84
32
DDX21DDX21Q9NR30Q9NR30chromatinremodelingdefenseresponsetovirusinnateimmuneresponseosteoblastdifferentiationpositiveregulationofhistoneacetylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIR-loopprocessingresponsetoexogenousdsRNArRNAprocessingtranscriptionbyRNApolymeraseII
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
9.8
53
38
SCOT1SCOT1Q29551Q29551cellularketonebodymetabolicprocessketonebodycatabolicprocess
Centromere protein M
8.7
82
34
CENPMCENPMQ9NSP4Q9NSP4
Methyltransferase N6AMT1
8.7
53
43
N6MT1N6MT1Q9Y5N5Q9Y5N5arsonoacetatemetabolicprocesschromatinorganizationDNAmethylationonadeninehistonelysinemethylationmethylationpeptidyl-glutaminemethylationpositiveregulationofcellgrowthtoxinmetabolicprocess
Protein TASOR
8.7
72
41
✔
TASORTASORQ9UK61Q9UK61anterior/posterioraxisspecificationembryomesodermaltomesenchymaltransitioninvolvedingastrulationnegativeregulationofgeneexpressionepigeneticnegativeregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatepositiveregulationofDNAmethylation-dependentheterochromatinformationproteinlocalizationtoheterochromatin
Dual specificity protein phosphatase 14
8.7
99
36
DUS14DUS14O95147O95147proteindephosphorylation
CAD protein
8.7
66
43
PYR1PYR1P27708P27708"denovopyrimidinenucleobasebiosyntheticprocess""denovoUMPbiosyntheticprocess"citrullinebiosyntheticprocessglutaminemetabolicprocessnitrogencompoundmetabolicprocesspeptidyl-threoninephosphorylationproteinautophosphorylationUDPbiosyntheticprocessUTPbiosyntheticprocess
STE20-related kinase adapter protein alpha
6.5
nan
62
STRAASTRAAQ7RTN6Q7RTN6activationofproteinkinaseactivityG1toG0transitionproteinexportfromnucleus
DNA topoisomerase 2-beta
8.7
75
40
TOP2BTOP2BQ02880Q02880axonogenesisBcelldifferentiationDNAtopologicalchangeforebraindevelopmentneuronmigrationpositiveregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediateresolutionofmeioticrecombinationintermediatessisterchromatidsegregation
D-aspartate oxidase
8.7
66
41
OXDDOXDDQ99489Q99489aspartatecatabolicprocessD-aminoacidcatabolicprocessgroomingbehaviorhormonemetabolicprocessinsemination
Rho GTPase-activating protein 7
8.7
73
41
RHG07RHG07Q96QB1Q96QB1actincytoskeletonorganizationactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocessfocaladhesionassemblyforebraindevelopmentheartmorphogenesishindbrainmorphogenesisnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationoffocaladhesionassemblynegativeregulationofRhoproteinsignaltransductionnegativeregulationofstressfiberassemblyneuraltubeclosurepositiveregulationofexecutionphaseofapoptosispositiveregulationofproteindephosphorylationregulationofactincytoskeletonorganizationregulationofcellshaperegulationofRhoproteinsignaltransductionregulationofsmallGTPasemediatedsignaltransductionsignaltransduction
Dipeptidyl peptidase 9
8.7
73
40
DPP9DPP9Q86TI2Q86TI2proteolysispyroptosis
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
8.7
51
47
MAGI2MAGI2Q86UL8Q86UL8cellularresponsetonervegrowthfactorstimulusclathrin-dependentendocytosisnegativeregulationofactivinreceptorsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofproteinkinaseBsignalingnervegrowthfactorsignalingpathwaynervoussystemdevelopmentplanarcellpolaritypathwayinvolvedinaxiselongationpodocytedevelopmentpositiveregulationofneuronprojectiondevelopmentpositiveregulationofphosphoproteinphosphataseactivitypositiveregulationofreceptorinternalizationreceptorclusteringsignaltransductionSMADproteinsignaltransduction
Fanconi-associated nuclease 1
9.8
42
44
FAN1FAN1Q9Y2M0Q9Y2M0DNArepairdouble-strandbreakrepairviahomologousrecombinationinterstrandcross-linkrepairnucleotide-excisionrepair
Ribosomal protein S6 kinase alpha-3
8.7
61
41
✔
KS6A3KS6A3P18654P18654cellcycleintracellularsignaltransductionnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspeptidyl-serinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIresponsetolipopolysaccharidetoll-likereceptorsignalingpathway
Steroid 21-hydroxylase
8.7
74
36
CP21ACP21AP00191P00191glucocorticoidbiosyntheticprocesssteroidbiosyntheticprocesssteroidmetabolicprocess
Dehydrodolichyl diphosphate synthase complex subunit DHDDS
8.7
68
39
DHDDSDHDDSQ86SQ9Q86SQ9dolichyldiphosphatebiosyntheticprocesspolyprenolbiosyntheticprocess
DNA repair protein XRCC1
8.7
61
48
XRCC1XRCC1P18887P18887base-excisionrepaircerebellummorphogenesisdouble-strandbreakrepairvianonhomologousendjoininghippocampusdevelopmentnegativeregulationofprotectionfromnon-homologousendjoiningattelomerenegativeregulationofproteinADP-ribosylationpositiveregulationofDNAligaseactivitypositiveregulationofsinglestrandbreakrepairreplication-borndouble-strandbreakrepairviasisterchromatidexchangeresponsetohydroperoxideresponsetohypoxiaresponsetoorganicsubstanceresponsetoxenobioticstimulussinglestrandbreakrepairtelomericDNA-containingdoubleminutesformationvoluntarymusculoskeletalmovement
Glycogen phosphorylase, brain form
8.7
90
32
PYGBPYGBP11216P11216glycogencatabolicprocess
Tyrosine-protein phosphatase non-receptor type 1
7.2
63
55
PTN1PTN1P18031P18031actincytoskeletonreorganizationcellularresponsetounfoldedproteinendoplasmicreticulumunfoldedproteinresponsegrowthhormonereceptorsignalingpathwayviaJAK-STATinsulinreceptorrecyclinginsulinreceptorsignalingpathwayIRE1-mediatedunfoldedproteinresponsenegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofERK1andERK2cascadenegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofMAPkinaseactivitynegativeregulationofPERK-mediatedunfoldedproteinresponsenegativeregulationofsignaltransductionnegativeregulationofvascularendothelialgrowthfactorreceptorsignalingpathwaypeptidyl-tyrosinedephosphorylationpeptidyl-tyrosinedephosphorylationinvolvedininactivationofproteinkinaseactivityplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofIRE1-mediatedunfoldedproteinresponsepositiveregulationofJUNkinaseactivitypositiveregulationofproteintyrosinekinaseactivitypositiveregulationofreceptorcatabolicprocessproteindephosphorylationregulationofendocytosisregulationofhepatocytegrowthfactorreceptorsignalingpathwayregulationofintracellularproteintransportregulationofsignaltransductionregulationoftypeIinterferon-mediatedsignalingpathway
Beta-crystallin B2
8.7
52
50
CRBB2CRBB2P02522P02522lensdevelopmentincamera-typeeyevisualperception
Interleukin-1 receptor-associated kinase 3
2.0
49
87
IRAK3IRAK3Q9Y616Q9Y616cytokine-mediatedsignalingpathwayinterleukin-1-mediatedsignalingpathwayintracellularsignaltransductionMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationofcytokine-mediatedsignalingpathwaynegativeregulationofinnateimmuneresponsenegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-6productionnegativeregulationofmacrophagecytokineproductionnegativeregulationofMAPkinaseactivitynegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteincatabolicprocessnegativeregulationofprotein-containingcomplexdisassemblynegativeregulationoftoll-likereceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionpositiveregulationofcytokineproductionpositiveregulationofmacrophagetoleranceinductionpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinautophosphorylationproteinphosphorylationregulationofprotein-containingcomplexdisassemblyresponsetoexogenousdsRNAresponsetointerleukin-1responsetolipopolysaccharideresponsetopeptidoglycanresponsetovirus
Retinol-binding protein 5
8.7
57
45
RET5RET5P82980P82980fattyacidtransport
Ribosomal oxygenase 2
8.8
64
42
RIOX2RIOX2Q8IUF8Q8IUF8histoneH3-K36demethylationhistoneH3-K4demethylationribosomebiogenesis
Regulator of G-protein signaling 8
8.8
68
42
RGS8RGS8P57771P57771Gprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaynegativeregulationofsignaltransductionpositiveregulationofGTPaseactivityregulationofdopaminereceptorsignalingpathway
Rho-associated protein kinase 1
8.8
69
47
ROCK1ROCK1Q13464Q13464actincytoskeletonorganizationactomyosinstructureorganizationaorticvalvemorphogenesisapicalconstrictionblebassemblybloodvesseldiametermaintenancecorticalactincytoskeletonorganizationembryonicmorphogenesisepithelialtomesenchymaltransitionI-kappaBkinase/NF-kappaBsignalingleukocytecell-celladhesionleukocytemigrationleukocytetetheringorrollingmembranetomembranedockingmitoticcytokinesismotorneuronapoptoticprocessmRNAdestabilizationmyoblastmigrationnegativeregulationofamyloidprecursorproteincatabolicprocessnegativeregulationofamyloid-betaformationnegativeregulationofangiogenesisnegativeregulationofbicellulartightjunctionassemblynegativeregulationofbiomineraltissuedevelopmentnegativeregulationofmembraneproteinectodomainproteolysisnegativeregulationofmotorneuronapoptoticprocessnegativeregulationofmyosin-light-chain-phosphataseactivitynegativeregulationofphosphorylationnegativeregulationofproteinbindingneuronprojectionarborizationneuronprojectiondevelopmentpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpodocytecellmigrationpositiveregulationofamyloid-betaclearancepositiveregulationofautophagypositiveregulationofcardiacmusclehypertrophypositiveregulationofconnectivetissuereplacementpositiveregulationofdephosphorylationpositiveregulationoffocaladhesionassemblypositiveregulationofgeneexpressionpositiveregulationofMAPKcascadepositiveregulationofphosphataseactivityproteinlocalizationtoplasmamembraneproteinphosphorylationregulationofactincytoskeletonorganizationregulationofamyloid-betaformationregulationofangiotensin-activatedsignalingpathwayregulationofautophagyregulationofcelladhesionregulationofcelljunctionassemblyregulationofcellmigrationregulationofcellmotilityregulationofestablishmentofcellpolarityregulationofestablishmentofendothelialbarrierregulationoffocaladhesionassemblyregulationofkeratinocytedifferentiationregulationofmicrotubulecytoskeletonorganizationregulationofneurondifferentiationregulationofstressfiberassemblyregulationofsynapsematurationregulationofsynapticvesicleendocytosisresponsetoangiotensinresponsetotransforminggrowthfactorbetaRhoproteinsignaltransductionsignaltransductionsmoothmusclecontraction
Phosphomannomutase 2
5.5
66
55
PMM2PMM2O15305O15305GDP-mannosebiosyntheticprocessmannosemetabolicprocessproteinglycosylationproteinN-linkedglycosylation
Krev interaction trapped protein 1
3.6
56
80
✔
SNX17KRIT1Q15036O00522aortadevelopmentcardiacseptumdevelopmentcholesterolcatabolicprocesscoronaryvasculaturedevelopmentendocyticrecyclingendosomaltransportintracellularproteintransportkidneydevelopmentreceptor-mediatedendocytosisregulationofendocytosissignaltransductionangiogenesiscellredoxhomeostasisendotheliumdevelopmentintegrinactivationnegativeregulationofangiogenesisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationpositiveregulationofproteinbindingregulationofangiogenesisregulationofestablishmentofcellpolaritysmallGTPasemediatedsignaltransduction
Histone chaperone ASF1A
8.8
62
39
ASF1AASF1AQ9Y294Q9Y294DNArepairDNAreplication-dependentchromatinassemblymusclecelldifferentiationnucleosomeassemblyosteoblastdifferentiation
TBC1 domain family member 20
8.8
44
51
TBC20TBC20Q96BZ9Q96BZ9acrosomeassemblyCOPII-coatedvesiclecargoloadingendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationlensfibercellmorphogenesislipiddropletorganizationpositiveregulationbyhostofviralgenomereplicationpositiveregulationbyvirusofviralproteinlevelsinhostcellpositiveregulationofERtoGolgivesicle-mediatedtransportpositiveregulationofGTPaseactivityseminiferoustubuledevelopmentvirionassembly
Dual specificity protein kinase CLK2
8.8
75
36
CLK2CLK2P49760P49760negativeregulationofgluconeogenesispeptidyl-tyrosinephosphorylationproteinautophosphorylationproteinphosphorylationregulationofRNAsplicingresponsetoionizingradiation
Cyclin-dependent kinase 6
4.3
49
74
✔
CDK6CDK6Q00534Q00534astrocytedevelopmentcelldedifferentiationcelldivisiondentategyrusdevelopmentG1/StransitionofmitoticcellcyclegenerationofneuronsgliogenesishematopoieticstemcelldifferentiationlateralventricledevelopmentnegativeregulationofcellcyclenegativeregulationofcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcellularsenescencenegativeregulationofepithelialcellproliferationnegativeregulationofmonocytedifferentiationnegativeregulationofmyeloidcelldifferentiationnegativeregulationofosteoblastdifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIINotchsignalingpathwaypositiveregulationofcell-matrixadhesionpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionproteinphosphorylationregulationofcellcycleregulationofcellmotilityregulationoferythrocytedifferentiationregulationofgeneexpressionregulationofhematopoieticstemcelldifferentiationresponsetovirusTcelldifferentiationinthymustypeBpancreaticcelldevelopment
Profilin-1
8.8
76
43
PROF1PROF1P07737P07737actincytoskeletonorganizationmodificationofpostsynapticactincytoskeletonmodulationofchemicalsynaptictransmissionnegativeregulationofactinfilamentbundleassemblynegativeregulationofactinfilamentpolymerizationnegativeregulationofstressfiberassemblyneuraltubeclosurepositiveregulationofactinfilamentbundleassemblypositiveregulationofactinfilamentpolymerizationpositiveregulationofATP-dependentactivitypositiveregulationofepithelialcellmigrationpositiveregulationofruffleassemblyproteinstabilizationregulationofactinfilamentpolymerizationregulationoftranscriptionbyRNApolymeraseIIsynapsematuration
Glyceraldehyde-3-phosphate dehydrogenase
8.8
97
31
✔
G3PG3PP04406P04406antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetotypeIIinterferondefenseresponsetofungusglucosemetabolicprocessglycolyticprocesskillingbyhostofsymbiontcellskillingofcellsofanotherorganismmicrotubulecytoskeletonorganizationnegativeregulationofendopeptidaseactivitynegativeregulationoftranslationneuronapoptoticprocesspeptidyl-cysteineS-trans-nitrosylationpositiveregulationofcytokineproductionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationoftypeIinterferonproductionproteinstabilizationregulationofmacroautophagy
Oxytocin-neurophysin 1
2.0
nan
92
NEU1NEU1P01178P01178drinkingbehavioreatingbehaviorfemalepregnancygroomingbehaviorheartdevelopmenthyperosmoticsalinityresponsemalematingbehaviormaternalaggressivebehaviormaternalbehaviormemorynegativeregulationofbloodpressurenegativeregulationofgastricacidsecretionnegativeregulationofurinevolumepositiveregulationofbloodpressurepositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationoffemalereceptivitypositiveregulationofhindgutcontractionpositiveregulationofnorepinephrinesecretionpositiveregulationofossificationpositiveregulationofpenileerectionpositiveregulationofprostaglandinsecretionpositiveregulationofrenalsodiumexcretionpositiveregulationofsynapseassemblypositiveregulationofsynaptictransmissionpositiveregulationofuterinesmoothmusclecontractionregulationofheartrateregulationofsensoryperceptionofpainresponsetoactivityresponsetoamphetamineresponsetocAMPresponsetococaineresponsetoelectricalstimulusresponsetoestradiolresponsetoetherresponsetofoodresponsetoglucocorticoidresponsetopeptidehormoneresponsetoprogesteroneresponsetoprostaglandinEresponsetoretinoicacidresponsetosucrosesignaltransductionsleepsocialbehaviorspermejaculation
Diamine acetyltransferase 1
5.3
59
65
SAT1SAT1P48026P48026polyaminebiosyntheticprocesspolyaminecatabolicprocesspolyaminemetabolicprocessputrescinecatabolicprocessregulationofcellpopulationproliferationspermidineacetylationsperminecatabolicprocess
Ragulator complex protein LAMTOR5
8.8
77
39
LTOR5LTOR5O43504O43504cellularresponsetoaminoacidstimulusnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-8productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinlocalizationtonucleuspositiveregulationofRNApolymeraseIIregulatoryregionsequence-specificDNAbindingpositiveregulationofTORsignalingpositiveregulationofTORC1signalingproteinlocalizationtolysosomeregulationofcellsizeresponsetovirusTORC1signalingviralgenomereplication
protein-serine/threonine phosphatase
8.3
76
38
Q4J6C0Q4J6C0Q4J6C0Q4J6C0proteindephosphorylation
Corrinoid adenosyltransferase MMAB
8.8
88
30
MMABMMABQ96EY8Q96EY8cobalaminmetabolicprocess
Acyl-coenzyme A thioesterase 11
8.8
88
31
ACO11ACO11Q8WXI4Q8WXI4acyl-CoAmetabolicprocessfattyacidmetabolicprocessintracellularsignaltransductionnegativeregulationofcold-inducedthermogenesisresponsetocoldresponsetotemperaturestimulus
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
8.8
86
38
✔
ODPBODPBP11177P11177acetyl-CoAbiosyntheticprocessfrompyruvateglucosemetabolicprocesstricarboxylicacidcycle
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
8.8
100
33
G3PTG3PTO14556O14556flagellatedspermmotilityglucosemetabolicprocessglycolyticprocesspositiveregulationofglycolyticprocess
Serine racemase
8.8
84
31
SRRSRRQ9GZT4Q9GZT4agingbraindevelopmentD-serinebiosyntheticprocessD-serinemetabolicprocessL-serinemetabolicprocesspyruvatebiosyntheticprocessresponsetolipopolysaccharideresponsetomorphineresponsetoxenobioticstimulusserinefamilyaminoacidmetabolicprocess
Glutathione S-transferase theta-1
8.8
75
40
GSTT1GSTT1P30711P30711glutathionemetabolicprocess
Cyclin-dependent kinase 9
4.7
54
72
CDK9CDK9P50750P50750cellpopulationproliferationcellularresponsetocytokinestimulusDNArepairphosphorylationofRNApolymeraseIIC-terminaldomainserine2residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterphosphorylationofRNApolymeraseIIC-terminaldomainserine5residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationbyhostofviraltranscriptionpositiveregulationofcardiacmusclehypertrophy"positiveregulationofmRNA3-UTRbinding"positiveregulationofproteinlocalizationtochromatinpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinphosphorylationregulationofcellcycleregulationofDNArepairregulationofhistonemodification"regulationofmRNA3-endprocessing"regulationofmusclecelldifferentiationreplicationforkprocessingresponsetoxenobioticstimulustranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromotertranscriptioninitiationatRNApolymeraseIIpromoter
Cerebral cavernous malformations 2 protein
6.8
57
56
CCM2CCM2Q9BSQ5Q9BSQ5bloodvesselendothelialcelldifferentiationcell-celljunctionorganizationendothelialcelldevelopmentendothelialtubemorphogenesisendotheliumdevelopmentheartdevelopmentinuteroembryonicdevelopmentinnereardevelopmentintegrin-mediatedsignalingpathwaymulticellularorganismgrowthpericardiumdevelopmentregulationofangiogenesisstress-activatedMAPKcascadevasculogenesisvenousbloodvesselmorphogenesis
Purine nucleoside phosphorylase
8.8
78
33
PNPHPNPHP00491P00491allantoinmetabolicprocessdAMPcatabolicprocessdeoxyadenosinecatabolicprocessdeoxyinosinecatabolicprocessimmuneresponseIMPcatabolicprocessinosinecatabolicprocessnicotinamideribosidecatabolicprocessnucleobase-containingcompoundmetabolicprocessnucleotidebiosyntheticprocesspositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofinterleukin-2productionpositiveregulationofTcellproliferationpurineribonucleosidesalvagepurine-containingcompoundsalvageresponsetoxenobioticstimulusuratebiosyntheticprocess
Aryl-hydrocarbon-interacting protein-like 1
8.8
54
44
AIPL1AIPL1Q9NZN9Q9NZN9apoptoticprocessnegativeregulationofapoptoticprocessphototransductionvisiblelightproteinfarnesylationregulationofrhodopsinmediatedsignalingpathwayretinahomeostasisvisualperception
26S proteasome non-ATPase regulatory subunit 4
9.3
72
39
Q9ESH1Q9ESH1Q9ESH1Q9ESH1fluidtransportproteasome-mediatedubiquitin-dependentproteincatabolicprocess
Methylthioribose-1-phosphate isomerase
8.8
55
43
MTNAMTNAQ9BV20Q9BV20L-methioninesalvagefrommethylthioadenosineL-methioninesalvagefromS-adenosylmethionine
C-C motif chemokine 21
2.0
56
86
CCL21CCL21O00585O00585activationofGTPaseactivityantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellchemotaxiscellmaturationcell-cellsignalingcellularresponsetochemokinecellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine(C-Cmotif)ligand21signalingpathwaychemokine-mediatedsignalingpathwaydendriticcellchemotaxisdendriticcelldendriteassemblyeosinophilchemotaxisestablishmentofTcellpolarityGprotein-coupledreceptorsignalingpathwayimmuneresponseimmunologicalsynapseformationinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismesangialcell-matrixadhesionmonocytechemotaxisnegativeregulationofdendriticcellapoptoticprocessnegativeregulationofdendriticcelldendriteassemblynegativeregulationofleukocytetetheringorrollingneutrophilchemotaxispositiveregulationofactinfilamentpolymerizationpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcellmotilitypositiveregulationofcell-matrixadhesionpositiveregulationofchemotaxispositiveregulationofdendriticcellantigenprocessingandpresentationpositiveregulationofERK1andERK2cascadepositiveregulationoffilopodiumassemblypositiveregulationofglycoproteinbiosyntheticprocesspositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofJNKcascadepositiveregulationofmyeloiddendriticcellchemotaxispositiveregulationofneutrophilchemotaxispositiveregulationofphosphatidylinositol3-kinaseactivitypositiveregulationofproteinkinaseactivitypositiveregulationofproteinkinaseBsignalingpositiveregulationofpseudopodiumassemblypositiveregulationofreceptor-mediatedendocytosispositiveregulationofTcellchemotaxispositiveregulationofTcellmigrationreleaseofsequesteredcalciumionintocytosolresponsetoprostaglandinEruffleorganizationTcellcostimulation
Dual specificity protein kinase CLK1
8.3
67
52
CLK1CLK1P49759P49759peptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpeptidyl-tyrosinephosphorylationproteinautophosphorylationproteinphosphorylationregulationofRNAsplicing
Ribonuclease L
8.8
60
45
A5H025A5H025A5H025A5H025mRNAprocessingproteinphosphorylationregulationofRNAmetabolicprocess
Persulfide dioxygenase ETHE1, mitochondrial
8.8
51
50
✔
ETHE1ETHE1O95571O95571glutathionemetabolicprocesshydrogensulfidemetabolicprocess
Cleavage stimulation factor subunit 3
8.8
60
38
CSTF3CSTF3Q99LI7Q99LI7"mRNA3-endprocessing""RNA3-endprocessing"
Receptor-type tyrosine-protein phosphatase kappa
2.0
40
88
PTPRKPTPRKQ15262Q15262celladhesioncellmigrationcellularresponsetoreactiveoxygenspeciescellularresponsetoUVfocaladhesionassemblynegativeregulationofcellcyclenegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofkeratinocyteproliferationproteindephosphorylationproteinlocalizationtocellsurfacesignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Ribosomal protein S6 kinase alpha-5
3.9
55
77
✔
KS6A5KS6A5O75582O75582axonguidanceinflammatoryresponseinterleukin-1-mediatedsignalingpathwayintracellularsignaltransductionnegativeregulationofcytokineproductionnegativeregulationofDNA-templatedtranscriptionpeptidyl-serinephosphorylationpositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpost-translationalproteinmodificationproteinphosphorylationregulationofDNA-templatedtranscriptionregulationofpostsynapseorganization
Homeodomain-interacting protein kinase 2
8.0
60
50
HIPK2HIPK2Q9H2X6Q9H2X6adultwalkingbehavioranterior/posteriorpatternspecificationcellpopulationproliferationcellularresponsetohypoxiaDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorembryoniccamera-typeeyemorphogenesisembryonicretinamorphogenesisincamera-typeeyeerythrocytedifferentiationeyedevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatorirismorphogenesislensinductionincamera-typeeyenegativeregulationofBMPsignalingpathwaynegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofubiquitin-dependentproteincatabolicprocessneuronapoptoticprocessneurondifferentiationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationPMLbodyorganizationpositiveregulationofangiogenesispositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofJNKcascadepositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteinphosphorylationregulationofcellcycleregulationofsignaltransductionbyp53classmediatorretinalayerformationSMADproteinsignaltransductionsmoothenedsignalingpathwaytransforminggrowthfactorbetareceptorsignalingpathwayvoluntarymusculoskeletalmovement
Ribosomal protein S6 kinase alpha-1
2.0
49
84
KS6A1KS6A1Q15418Q15418cellcyclechemicalsynaptictransmissionhepatocyteproliferationintracellularsignaltransductionnegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTORsignalingpeptidyl-serinephosphorylationpositiveregulationofcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofDNA-templatedtranscriptionpositiveregulationofhepaticstellatecellactivationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinphosphorylationregulationofDNA-templatedtranscriptioninresponsetostressregulationoftranslationinresponsetostresssignaltransduction
Ryanodine receptor 1
4.4
67
78
RYR1RYR1P11716P11716calciumiontransmembranetransportcellularcalciumionhomeostasiscellularresponsetocaffeinecellularresponsetocalciumionmusclecontractionossificationinvolvedinbonematurationoutflowtractmorphogenesisproteinhomotetramerizationreleaseofsequesteredcalciumionintocytosolreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumskeletalmusclefiberdevelopmentskindevelopment
Protein ECT2
8.8
75
37
ECT2ECT2Q9H8V3Q9H8V3activationofGTPaseactivityactivationofproteinkinaseactivitybicellulartightjunctionassemblycelldifferentiationcellmorphogenesiscellularresponsetocalciumioncellularresponsetohydrogenperoxidecellularresponsetoionizingradiationintracellularsignaltransductionmitoticcytokinesisnervoussystemdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcytokinesispositiveregulationofGTPaseactivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofneurondifferentiationpositiveregulationofproteinimportintonucleusproteinhomooligomerizationproteintransportregulationofattachmentofspindlemicrotubulestokinetochoreregulationofcytokinesisactomyosincontractileringassemblyregulationofproteinkinaseactivityregulationofsmallGTPasemediatedsignaltransduction
General transcription factor II-I repeat domain-containing protein 2B
8.8
62
42
GTD2BGTD2BQ6EKJ0Q6EKJ0
E3 ubiquitin-protein ligase SMURF2
2.0
nan
86
SMUF2UBBQ9HAU4P0CG47negativeregulationofBMPsignalingpathwaynegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwaypositiveregulationoftrophoblastcellmigrationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationregulationoftransforminggrowthfactorbetareceptorsignalingpathwayubiquitin-dependentproteincatabolicprocessubiquitin-dependentSMADproteincatabolicprocessWntsignalingpathwayplanarcellpolaritypathwayenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
G/T mismatch-specific thymine DNA glycosylase
8.8
50
35
✔
TDGTDGQ13569Q13569base-excisionrepairbase-excisionrepairAPsiteformationdepyrimidinationDNAdemethylationepigeneticregulationofgeneexpressionmismatchrepairnegativeregulationofchromatinbindingnegativeregulationofproteinbindingnegativeregulationoftranscriptionbyRNApolymeraseIIoxidativeDNAdemethylationregulationofDNAN-glycosylaseactivityregulationofembryonicdevelopment
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
8.8
40
49
2A5A2A5AQ15172Q15172negativeregulationoflipidkinaseactivitynegativeregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteindephosphorylationproteindephosphorylationsignaltransduction
Microtubule-associated proteins 1A/1B light chain 3A
8.8
66
39
MLP3AMLP3AQ9H492Q9H492autophagosomeassemblyautophagosomematurationautophagyofmitochondrioncellularresponsetoaminoacidstarvationcellularresponsetocopperioncellularresponsetohydrogenperoxidecellularresponsetonitrogenstarvationcellularresponsetostarvationmacroautophagyresponsetoiron(II)ionresponsetoleadionresponsetomorphine
AP-1 complex subunit sigma-3
8.8
86
29
AP1S3AP1S3Q96PC3Q96PC3melanosomeassemblyplateletdensegranuleorganizationproteintargetingvesicle-mediatedtransport
Histone-lysine N-methyltransferase PRDM16
8.8
36
50
PRD16PRD16Q9HAZ2Q9HAZ2brownfatcelldifferentiationheterochromatinorganizationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgranulocytedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofcold-inducedthermogenesispositiveregulationofDNA-templatedtranscriptionregulationofcellularrespirationregulationoftranscriptionbyRNApolymeraseII
tRNA selenocysteine 1-associated protein 1
8.8
59
45
TSAP1TSAP1Q9NX07Q9NX07selenocysteineincorporation
Integrin beta-1-binding protein 1
3.8
69
77
ITBP1ITBP1O14713O14713activationofproteinkinaseBactivitybiomineraltissuedevelopmentbloodvesseldiametermaintenancebloodvesselendothelialcellproliferationinvolvedinsproutingangiogenesiscelldifferentiationcellmigrationcell-matrixadhesioncellularresponsetofibroblastgrowthfactorstimuluscellularresponsetovascularendothelialgrowthfactorstimulusintegrinactivationintegrin-mediatedsignalingpathwayintracellularsignaltransductionmyoblastmigrationnegativeregulationofcelladhesioninvolvedinsubstrate-boundcellmigrationnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofERK1andERK2cascadenegativeregulationoffibroblastmigrationnegativeregulationoffocaladhesionassemblynegativeregulationofproteinbindingnegativeregulationofproteinkinaseactivitynegativeregulationofproteintargetingtomembranenegativeregulationofsubstrateadhesion-dependentcellspreadingNotchsignalingpathwaypositiveregulationofcelldivisionpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellmigrationpositiveregulationoffocaladhesionassemblypositiveregulationofNotchsignalingpathwaypositiveregulationofproteinkinaseBsignalingpositiveregulationofproteintargetingtomembranepositiveregulationofstressfiberassemblypositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtoplasmamembranereceptorclusteringregulationofcelladhesionmediatedbyintegrinregulationofGTPaseactivityregulationofintegrin-mediatedsignalingpathwaytubeformation
Ras-related protein Rab-4A
8.8
91
30
RAB4ARAB4AP20338P20338antigenprocessingandpresentationproteintransportRabproteinsignaltransductionregulationofendocytosisvesicle-mediatedtransport
Catenin beta-1
8.8
72
38
CTNB1CTNB1P35222P35222acinarcelldifferentiationadherensjunctionassemblyanterior/posterioraxisspecificationapoptoticsignalingpathwayastrocyte-dopaminergicneuronsignalingboneresorptionbranchinginvolvedinbloodvesselmorphogenesisbranchinginvolvedinuretericbudmorphogenesiscanonicalWntsignalingpathwaycanonicalWntsignalingpathwayinvolvedinmesenchymalstemcelldifferentiationcanonicalWntsignalingpathwayinvolvedinmidbraindopaminergicneurondifferentiationcanonicalWntsignalingpathwayinvolvedinnegativeregulationofapoptoticprocesscanonicalWntsignalingpathwayinvolvedinosteoblastdifferentiationcanonicalWntsignalingpathwayinvolvedinpositiveregulationofcardiacoutflowtractcellproliferationcanonicalWntsignalingpathwayinvolvedinpositiveregulationofepithelialtomesenchymaltransitioncelladhesioncellfatespecificationcellmaturationcellmorphogenesisinvolvedindifferentiationcell-celladhesioncell-matrixadhesioncellularresponsetogrowthfactorstimuluscellularresponsetoindole-3-methanolcentralnervoussystemvasculogenesischemicalsynaptictransmissionchondrocytedifferentiationcranialgangliondevelopmentcranialskeletalsystemdevelopmentdetectionofmusclestretchdorsalrootgangliondevelopmentdorsal/ventralaxisspecificationectodermdevelopmentembryonicaxisspecificationembryonicbraindevelopmentembryonicdigitmorphogenesisembryonicforegutmorphogenesisembryonicforelimbmorphogenesisembryonichearttubedevelopmentembryonichindlimbmorphogenesisembryonicskeletallimbjointmorphogenesisendodermalcellfatecommitmentendothelialtubemorphogenesisepithelialcelldifferentiationinvolvedinprostateglanddevelopmentepithelialcellproliferationinvolvedinprostateglanddevelopmentepithelialtomesenchymaltransitionepithelialtubebranchinginvolvedinlungmorphogenesisfibroblastgrowthfactorreceptorsignalingpathwayfungiformpapillaformationgastrulationwithmouthformingsecondgenitaliamorphogenesisglialcellfatedeterminationhaircelldifferentiationhairfolliclemorphogenesishairfollicleplacodeformationhindbraindevelopmenthypothalamusdevelopmentI-kappaBkinase/NF-kappaBsignalinginuteroembryonicdevelopmentlayerformationincerebralcortexlensmorphogenesisincamera-typeeyelungepithelialcelldifferentiationlunginductionlung-associatedmesenchymedevelopmentmalegenitaliadevelopmentMAPKcascademesenchymalcellproliferationinvolvedinlungdevelopmentmesenchymalstemcelldifferentiationmetanephrosmorphogenesismidbraindopaminergicneurondifferentiationmyoblastproliferationnegativeregulationofangiogenesisnegativeregulationofapoptoticprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofchondrocytedifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationofmesenchymaltoepithelialtransitioninvolvedinmetanephrosmorphogenesisnegativeregulationofmitoticcellcycleembryonicnegativeregulationofoligodendrocytedifferentiationnegativeregulationofosteoclastdifferentiationnegativeregulationofoxidativestress-inducedneurondeathnegativeregulationofproteinsumoylationnegativeregulationoftranscriptionbyRNApolymeraseIInephrontubuleformationneuralplatedevelopmentneuroblastproliferationneuronfatedeterminationneuronmigrationneuronprojectionextensionodontogenesisofdentin-containingtootholigodendrocytedifferentiationoocytedevelopmentosteoclastdifferentiationoviductdevelopmentpancreasdevelopmentpositiveregulationofapoptoticprocesspositiveregulationofbranchinginvolvedinlungmorphogenesispositiveregulationofcelldifferentiationpositiveregulationofcorepromoterbindingpositiveregulationofdeterminationofdorsalidentitypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcelldifferentiationpositiveregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoffibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationofheparansulfateproteoglycanbiosyntheticprocesspositiveregulationofhistoneH3-K4methylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofMAPKcascadepositiveregulationofmesenchymalcellproliferationpositiveregulationofmyoblastproliferationpositiveregulationofneuroblastproliferationpositiveregulationofneuronapoptoticprocesspositiveregulationofosteoblastdifferentiationpositiveregulationofskeletalmuscletissuedevelopmentpositiveregulationofstemcellproliferationpositiveregulationoftelomeraseactivitypositiveregulationoftelomeremaintenanceviatelomerasepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinlocalizationtocellsurfaceproteinpolyubiquitinationproximal/distalpatternformationregulationofangiogenesisregulationofcalciumionimportregulationofcentriole-centriolecohesionregulationofcentromericsisterchromatidcohesionregulationoffibroblastproliferationregulationofmyelinationregulationofnephrontubuleepithelialcelldifferentiationregulationofneurogenesisregulationofproteinlocalizationtocellsurfaceregulationofsecondaryheartfieldcardioblastproliferationregulationofsmoothmusclecellproliferationregulationofsynapseassemblyregulationofTcellproliferationregulationoftimingofanagenrenalinnermedulladevelopmentrenaloutermedulladevelopmentrenalvesicleformationresponsetoestradiolresponsetoxenobioticstimulussmoothmusclecelldifferentiationstemcellpopulationmaintenancestemcellproliferationsympatheticgangliondevelopmentsynapseorganizationsynapticvesicleclusteringsynapticvesicletransportTcelldifferentiationinthymusthymusdevelopmenttracheaformationtranscriptionbyRNApolymeraseII
Interferon-induced GTP-binding protein Mx2
8.8
76
40
MX2MX2P20592P20592defenseresponsedefenseresponsetovirusinnateimmuneresponsemRNAtransportproteintransportregulationofcellcycleregulationofnucleocytoplasmictransportresponsetointerferon-alpharesponsetovirus
ATP synthase F(0) complex subunit C1, mitochondrial
8.8
90
36
AT5G1AT5G1P17605P17605protonmotiveforce-drivenATPsynthesis
Serine/threonine-protein phosphatase 5
8.8
70
35
✔
PPP5PPP5P53041P53041DNA-templatedtranscriptiondouble-strandbreakrepairMAPKcascademitoticcellcyclepeptidyl-serinedephosphorylationpeptidyl-threoninedephosphorylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingproteindephosphorylationresponsetoarachidonicacidresponsetoleadionresponsetomorphine
Signal recognition particle subunit SRP54
8.8
99
27
SRP54SRP54P61011P61011exocrinepancreasdevelopmentgranulocytedifferentiationneutrophilchemotaxisproteintargetingtoERSRP-dependentcotranslationalproteintargetingtomembraneSRP-dependentcotranslationalproteintargetingtomembranesignalsequencerecognitionSRP-dependentcotranslationalproteintargetingtomembranetranslocation
Signal transducer and activator of transcription 5A
8.8
56
45
STA5ASTA5AP42229P42229cytokine-mediatedsignalingpathwaydefenseresponsegrowthhormonereceptorsignalingpathwayviaJAK-STATlactationpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIreceptorsignalingpathwayviaJAK-STATreelin-mediatedsignalingpathwayregulationofcellpopulationproliferationregulationofmulticellularorganismgrowthregulationoftranscriptionbyRNApolymeraseIIresponsetopeptidehormonetaurinemetabolicprocess
Tubulin gamma-1 chain
8.8
93
26
TBG1TBG1P23258P23258cytoplasmicmicrotubuleorganizationmeioticspindleorganizationmicrotubulecytoskeletonorganizationmicrotubulenucleationmitoticcellcyclemitoticsisterchromatidsegregationmitoticspindleorganization
S-adenosylmethionine synthase isoform type-2
8.8
74
40
METK2METK2P31153P31153cellularresponsetoleukemiainhibitoryfactorone-carbonmetabolicprocessproteinheterooligomerizationproteinhexamerizationS-adenosylmethioninebiosyntheticprocess
Caspase-6
9.8
63
39
✔
CASP6CASP6P55212P55212activationofcysteine-typeendopeptidaseactivityactivationofinnateimmuneresponseapoptoticprocesscellularresponsetostaurosporineepithelialcelldifferentiationhepatocyteapoptoticprocessintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofapoptoticprocesspositiveregulationofnecroptoticprocessproteinautoprocessingproteolysispyroptosisregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathway
NADPH--cytochrome P450 reductase
8.8
76
35
NCPRNCPRP16435P16435carnitinemetabolicprocesscellularorganofluorinemetabolicprocesscellularresponsetofollicle-stimulatinghormonestimuluscellularresponsetopeptidehormonestimulusdemethylationelectrontransportchainfattyacidoxidationflavonoidmetabolicprocessinternalpeptidyl-lysineacetylationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationoflipaseactivitynitratecatabolicprocessnitricoxidecatabolicprocesspositiveregulationofcholesterolbiosyntheticprocesspositiveregulationofchondrocytedifferentiationpositiveregulationofmonooxygenaseactivitypositiveregulationofsmoothenedsignalingpathwaypositiveregulationofsteroidhormonebiosyntheticprocessregulationofgrowthplatecartilagechondrocyteproliferationresponsetodexamethasoneresponsetohormoneresponsetonutrientxenobioticmetabolicprocess
Poly [ADP-ribose] polymerase 2
7.8
64
51
PARP2PARP2O88554O88554base-excisionrepairdecidualizationDNAADP-ribosylationDNArepairdouble-strandbreakrepairextrinsicapoptoticsignalingpathwayhistonemodificationnegativeregulationofneurondeathpositiveregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentproteinauto-ADP-ribosylationproteinpoly-ADP-ribosylation
Tribbles homolog 2
8.8
58
45
TRIB2TRIB2Q92519Q92519negativeregulationoffatcelldifferentiationnegativeregulationofinterleukin-10productionnegativeregulationofproteinkinaseactivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessregulationofMAPkinaseactivity
AP-2 complex subunit alpha
8.9
68
42
Q66HM2Q66HM2Q66HM2Q66HM2clathrin-dependentendocytosisintracellularproteintransport
Glutathione S-transferase omega-1
8.8
69
37
✔
GSTO1GSTO1P78417P78417cellularresponsetoarsenic-containingsubstanceglutathionemetabolicprocessL-ascorbicacidmetabolicprocessnegativeregulationofryanodine-sensitivecalcium-releasechannelactivitypositiveregulationofryanodine-sensitivecalcium-releasechannelactivitypositiveregulationofskeletalmusclecontractionbyregulationofreleaseofsequesteredcalciumionregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumxenobioticcatabolicprocess
Adenylate cyclase type 2
9.8
49
48
ADCY2ADCY2P26769P26769adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycAMPbiosyntheticprocesscAMP-mediatedsignalingcellularresponsetoforskolin
THO complex subunit 1
8.8
67
40
✔
THOC1THOC2Q96FV9Q8NI27apoptoticprocessmRNAexportfromnucleusmRNAprocessingnegativeregulationofDNAdamagecheckpointnegativeregulationofisotypeswitchingtoIgAisotypespositiveregulationofDNA-templatedtranscriptionelongationregulationofDNArecombinationregulationofDNA-templatedtranscriptionelongationreplicationforkprocessingRNAprocessingRNAsplicingsignaltransductionviralmRNAexportfromhostcellnucleusgenerationofneuronsneurondevelopmentpoly(A)+mRNAexportfromnucleus
Cyclin-D1-binding protein 1
8.8
79
37
CCDB1CCDB1O95273O95273cellcycleregulationofcellcycle
MAD2L1-binding protein
3.9
65
73
MD2BPMD2BPQ15013Q15013deactivationofmitoticspindleassemblycheckpointregulationofexitfrommitosis
Kinesin light chain
2.0
59
85
Q91YS4Q91YS4Q91YS4Q91YS4lysosomelocalization
Kinesin light chain 1
8.8
70
41
KLC1KLC1Q07866Q07866microtubule-basedmovementstressgranuledisassembly
Proteasome subunit alpha type-1
9.5
83
36
PSA1Q6P6U2P18420Q6P6U2immunesystemprocessnegativeregulationofinflammatoryresponsetoantigenicstimulusproteasomalproteincatabolicprocessubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
RecQ-mediated genome instability protein 2
8.9
69
43
RMI2RMI2Q96E14Q96E14DNArepairDNAreplicationdouble-strandbreakrepairviahomologousrecombinationmaintenanceofrDNAnegativeregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofsisterchromatidsegregationresolutionofrecombinationintermediates
Sestrin-2
8.9
86
35
SESN2SESN2P58004P58004activationofproteinkinaseactivitycellularoxidantdetoxificationcellularresponsetoaminoacidstarvationcellularresponsetoaminoacidstimuluscellularresponsetoglucosestarvationcellularresponsetoleucinecellularresponsetoleucinestarvationcellularresponsetooxidativestressDNAdamageresponsesignaltransductionbyp53classmediatorfattyacidbeta-oxidationglucosehomeostasisglucoseimportmitochondrialDNAmetabolicprocessnegativeregulationofcellgrowthnegativeregulationofTORC1signalingnegativeregulationoftranslationinresponsetoendoplasmicreticulumstresspositiveregulationoflipophagypositiveregulationofmacroautophagypositiveregulationofproteinlocalizationtonucleusproteinkinaseBsignalingreactiveoxygenspeciesmetabolicprocessregulationofcAMP-dependentproteinkinaseactivityregulationofgluconeogenesisregulationofproteinphosphorylationregulationofresponsetoreactiveoxygenspeciesresponsetoglucoseresponsetoinsulintriglyceridehomeostasis
BAG family molecular chaperone regulator 2
8.9
81
36
BAG2BAG2Q91YN9Q91YN9negativeregulationofproteinbindingnegativeregulationofproteinubiquitinationnegativeregulationofubiquitinproteinligaseactivitypositiveregulationofproteasomalproteincatabolicprocesspositiveregulationofproteinprocessingproteinmetabolicprocessproteinstabilization
Glutamate receptor
8.9
58
47
G3V9I2G3V9I2G3V9I2G3V9I2
Ras-related C3 botulinum toxin substrate 1
6.5
57
56
RAC1RAC1P63000P63000actincytoskeletonorganizationactinfilamentorganizationactinfilamentpolymerizationanatomicalstructuremorphogenesiscelladhesioncellmigrationcellmotilitycellprojectionassemblycell-matrixadhesioncorticalcytoskeletonorganizationengulfmentofapoptoticcellestablishmentormaintenanceofcellpolarityhepatocytegrowthfactorreceptorsignalingpathwayinflammatoryresponseintracellularsignaltransductionlamellipodiumassemblylocalizationlocalizationwithinmembranemotorneuronaxonguidancenegativeregulationoffibroblastmigrationnegativeregulationofinterleukin-23productionnegativeregulationofreceptor-mediatedendocytosisneuronmigrationpositiveregulationofcell-substrateadhesionpositiveregulationofendothelialcellmigrationpositiveregulationoffocaladhesionassemblypositiveregulationoflamellipodiumassemblypositiveregulationofmicrotubulepolymerizationpositiveregulationofneutrophilchemotaxispositiveregulationofproteinphosphorylationpositiveregulationofRhoproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingRacproteinsignaltransductionregulationofactincytoskeletonorganizationregulationofcellmigrationregulationofcellshaperegulationofcellsizeregulationofhydrogenperoxidemetabolicprocessregulationoflamellipodiumassemblyregulationofneutrophilmigrationregulationofnitricoxidebiosyntheticprocessregulationofrespiratoryburstregulationofstressfiberassemblyrespiratoryburstresponsetowoundingruffleassemblyruffleorganizationsemaphorin-plexinsignalingpathwaysmallGTPasemediatedsignaltransductionsphingosine-1-phosphatereceptorsignalingpathwaysubstrateadhesion-dependentcellspreadingWntsignalingpathwayplanarcellpolaritypathway
Nuclear autoantigen Sp-100
3.7
52
87
SP100SP100P23497P23497DNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatormaintenanceofproteinlocationnegativeregulationofDNAbindingnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofendothelialcellmigrationnegativeregulationofproteinexportfromnucleusnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviraltranscriptionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsregulationofFassignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetocytokineresponsetoretinoicacidresponsetotypeIinterferonresponsetotypeIIinterferonretinoicacidreceptorsignalingpathwaytelomeremaintenancetypeIinterferon-mediatedsignalingpathwaytypeIIinterferon-mediatedsignalingpathway
Ras-related protein Rap-1A
8.9
47
47
RAP1ARAP1AP62834P62834cellularresponsetocAMPcellularresponsetonervegrowthfactorstimulusestablishmentofendothelialbarriernegativeregulationofsynapticvesicleexocytosisnervegrowthfactorsignalingpathwaynervoussystemdevelopmentpositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivitypositiveregulationofneuronprojectiondevelopmentpositiveregulationofproteinkinaseactivitypositiveregulationofvasculogenesisproteinlocalizationtoplasmamembraneRapproteinsignaltransductionregulationofcelljunctionassemblyregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembranesynapticvesicleexocytosis
Protein N-terminal asparagine amidohydrolase
8.9
97
27
NTAN1NTAN1Q96AB6Q96AB6adultlocomotorybehaviormemoryubiquitin-dependentproteincatabolicprocess
DNA polymerase iota
4.6
62
68
POLIPOLIQ9UNA4Q9UNA4DNArepairDNAreplicationerror-pronetranslesionsynthesistranslesionsynthesis
YTH domain-containing protein 1
8.9
76
38
YTDC1YTDC1Q96MU7Q96MU7dosagecompensationbyinactivationofXchromosomeinuteroembryonicdevelopmentmRNAalternativepolyadenylationmRNAexportfromnucleusmRNAsplicesiteselectionmRNAsplicingviaspliceosomepost-transcriptionalregulationofgeneexpressionprimaryfolliclestageregulationofalternativemRNAsplicingviaspliceosomeregulationofmRNAsplicingviaspliceosomespermatogenesis
Protein mono-ADP-ribosyltransferase PARP14
7.5
48
48
PAR14PAR14Q460N5Q460N5innateimmuneresponsenegativeregulationofgeneexpressionnegativeregulationoftypeIIinterferon-mediatedsignalingpathwaynegativeregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofinterleukin-4-mediatedsignalingpathwaypositiveregulationoftyrosinephosphorylationofSTATproteinproteinpoly-ADP-ribosylation
glutamate dehydrogenase [NAD(P)(+)]
8.9
79
34
A0A140T871A0A140T871A0A140T871A0A140T871glutaminemetabolicprocesspositiveregulationofinsulinsecretiontricarboxylicacidmetabolicprocess
Histone chaperone ASF1B
8.9
58
41
ASF1BASF1BQ9NVP2Q9NVP2blastocysthatchingcelldifferentiationDNAreplication-dependentchromatinassemblynucleosomeassemblyspermatogenesis
Regulator of G-protein signaling 4
8.9
68
41
RGS4RGS4P49799P49799braindevelopmentdorsalrootgangliondevelopmentnegativeregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentnegativeregulationofdopaminereceptorsignalingpathwaynegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglycineimportacrossplasmamembranenegativeregulationofpotassiumiontransmembranetransportpositiveregulationofexcitatorypostsynapticpotentialpositiveregulationofGTPaseactivitypositiveregulationofheartrateregulationofactinfilamentorganizationregulationofcalciumiontransportregulationofpotassiumiontransmembranetransportresponsetoamphetamineresponsetococaineresponsetoethanolresponsetomorphine
Serine/threonine-protein kinase N1
9.5
59
36
PKN1PKN1Q16512Q16512BcellapoptoticprocessBcellhomeostasischromatinorganizationepithelialcellmigrationhyperosmoticresponseintracellularsignaltransductionnegativeregulationofBcellproliferationnegativeregulationofproteinkinaseactivitypeptidyl-serinephosphorylationpost-translationalproteinmodificationproteinphosphorylationregulationofandrogenreceptorsignalingpathwayregulationofcellmotilityregulationofgerminalcenterformationregulationofimmunoglobulinproductionregulationoftranscriptionbyRNApolymeraseIIrenalsystemprocesssignaltransductionspleendevelopment
Zinc finger CCCH domain-containing protein 13
8.9
73
39
ZC3HDZC3HDQ5T200Q5T200mRNAmethylationmRNAprocessingregulationofstemcellpopulationmaintenanceRNAsplicing
Major facilitator superfamily domain-containing protein 10
8.9
80
34
MFS10MFS10Q14728Q14728apoptoticprocesssodium-independentorganicaniontransport
SPRY domain-containing protein 7
8.9
96
31
SPRY7SPRY7Q5W111Q5W111
Rabphilin-3A
8.9
77
34
RP3ARP3AP47709P47709braindevelopmentdendriticspineorganizationexocytosisintracellularproteintransportregulationofcalciumion-dependentexocytosisregulationofNMDAreceptoractivityspontaneousneurotransmittersecretionsynapticvesiclepriming
Mitochondrial chaperone BCS1
8.9
61
43
BCS1BCS1Q9CZP5Q9CZP5mitochondrialcytochromecoxidaseassemblymitochondrialrespiratorychaincomplexIassemblymitochondrialrespiratorychaincomplexIIIassemblymitochondrionorganizationproteininsertionintomitochondrialinnermembranefrommatrix
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
8.9
56
42
2A5G2A5GQ13362Q13362DNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofcellpopulationproliferationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindephosphorylationsignaltransduction
FACT complex subunit SSRP1
8.9
67
39
✔
SSRP1SSRP1Q08945Q08945DNArepairDNAreplicationnucleosomeassemblynucleosomedisassemblyregulationofchromatinorganization
Microtubule-associated protein RP/EB family member 3
8.6
55
46
MARE1MARE3Q15691Q9UPY8attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncellmigrationestablishmentofmitoticspindleorientationmicrotubulebundleformationmicrotubulepolymerizationnegativeregulationofmicrotubulepolymerizationnon-motileciliumassemblypositiveregulationofmicrotubuleplus-endbindingpositiveregulationofmicrotubulepolymerizationproteinlocalizationproteinlocalizationtoastralmicrotubuleproteinlocalizationtocentrosomeproteinlocalizationtomicrotubuleregulationofmicrotubulepolymerizationordepolymerizationspindleassemblypositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinkinaseactivityregulationofmicrotubulepolymerization
Heterogeneous nuclear ribonucleoprotein M
8.9
58
44
HNRPMHNRPMP52272P52272alternativemRNAsplicingviaspliceosomemRNAsplicingviaspliceosomeregulationofmRNAstabilityinvolvedinresponsetooxidativestress
fructose-bisphosphatase
8.9
71
31
Q2TU34Q2TU34Q2TU34Q2TU34gluconeogenesis
Centromere protein S
8.9
64
43
CENPSCENPSQ8N2Z9Q8N2Z9celldivisioncellularresponsetoDNAdamagestimulusDNArepairinterstrandcross-linkrepairpositiveregulationofproteinubiquitinationreplicationforkprocessingresolutionofmeioticrecombinationintermediates
Dedicator of cytokinesis protein 9
8.9
71
39
DOCK9DOCK9Q9BZ29Q9BZ29positiveregulationofGTPaseactivitysmallGTPasemediatedsignaltransduction
Nuclear receptor subfamily 1 group I member 2
8.9
64
32
NR1I2NR1I2O75469O75469celldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionsignaltransductionsteroidmetabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocessxenobiotictransport
Dynein light chain 2, cytoplasmic
8.9
78
34
DYL2DYL2Q9D0M5Q9D0M5microtubule-basedprocess
Matrin-3
8.9
42
50
MATR3MATR3Q8K310Q8K310activationofinnateimmuneresponseblastocystformationheartvalvedevelopmentinnateimmuneresponsepost-transcriptionalregulationofgeneexpressionventricularseptumdevelopment
Protein prenyltransferase alpha subunit repeat-containing protein 1
8.9
59
43
PTAR1PTAR1Q7Z6K3Q7Z6K3proteinprenylation
Forkhead box protein N3
8.9
61
42
FOXN3FOXN3O00409O00409craniofacialsuturemorphogenesismitoticG2DNAdamagecheckpointsignalingnegativeregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscription
Unconventional myosin-Vc
8.9
83
40
MYO5CMYO5CQ9NQX4Q9NQX4actinfilamentorganizationvesicletransportalongactinfilament
Tubulin beta chain
8.9
50
44
D0VWY9D0VWY9D0VWY9D0VWY9microtubule-basedprocess
Actin-related protein 2/3 complex subunit 3
8.9
59
43
ARPC3ARPC3Q3T035Q3T035Arp2/3complex-mediatedactinnucleationregulationofactinfilamentpolymerization
Rho guanine nucleotide exchange factor 2
3.6
89
70
ARHG2ARHG2Q60875Q60875actinfilamentorganizationasymmetricneuroblastdivisioncellmorphogenesiscellularresponsetomuramyldipeptideestablishmentofmitoticspindleorientationinnateimmuneresponsenegativeregulationofmicrotubuledepolymerizationnegativeregulationofneurogenesisnegativeregulationofpodosomeassemblypositiveregulationofinterleukin-6productionpositiveregulationofneurondifferentiationpositiveregulationofneuronmigrationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionregulationofRhoproteinsignaltransduction
StAR-related lipid transfer protein 6
8.9
85
31
STAR6STAR6P59095P59095lipidtransport
Calcium-binding protein 1
8.9
64
44
CABP1CABP1Q9NZU7Q9NZU7negativeregulationofproteinimportintonucleusregulationofvoltage-gatedcalciumchannelactivityresponsetostimulusvisualperception
Centrosomal protein of 120 kDa
8.9
55
43
CE120CE120Q8N960Q8N960astralmicrotubuleorganizationcentrosomecyclecerebralcortexdevelopmentinterkineticnuclearmigrationneurogenesispositiveregulationofcentrioleelongationpositiveregulationofcentrosomeduplicationpositiveregulationofciliumassemblypositiveregulationofestablishmentofproteinlocalization
Trimethylguanosine synthase
8.9
89
30
TGS1TGS1Q96RS0Q96RS07-methylguanosinecaphypermethylation7-methylguanosineRNAcappingribonucleoproteincomplexbiogenesisspliceosomalsnRNPassembly
General transcription factor II-I
8.9
63
40
GTF2IGTF2IP78347P78347negativeregulationofangiogenesispositiveregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseII
Angiopoietin-related protein 2
8.9
89
40
ANGL2ANGL2Q9UKU9Q9UKU9cell-cellsignaling
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
8.9
78
35
TRM6TRM6Q9UJA5Q9UJA5mRNAmethylationtRNAmethylation
Junction plakoglobin
8.9
97
30
PLAKPLAKP14923P14923bundleofHiscell-PurkinjemyocyteadhesioninvolvedincellcommunicationcanonicalWntsignalingpathwaycellmigrationcell-celladhesioncellularresponsetoindole-3-methanoldesmosomeassemblydetectionofmechanicalstimulusendothelialcell-celladhesionnegativeregulationofbloodvesselendothelialcellmigrationpositiveregulationofangiogenesispositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcell-matrixadhesionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofproteinimportintonucleuspositiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtoplasmamembraneregulationofcellpopulationproliferationregulationofheartratebycardiacconductionregulationofventricularcardiacmusclecellactionpotentialskindevelopment
Adhesion G-protein coupled receptor G1
2.0
68
85
AGRG1AGRG1Q8K209Q8K209adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayangiogenesisbraindevelopmentcelladhesioncellmigrationcellsurfacereceptorsignalingpathwaycerebralcortexradialglia-guidedmigrationcerebralcortexregionalizationhematopoieticstemcellhomeostasislayerformationincerebralcortexnegativeregulationofcellpopulationproliferationnegativeregulationofneuronmigrationneuralprecursorcellproliferationpositiveregulationofcelladhesionpositiveregulationofneuralprecursorcellproliferationpositiveregulationofRhoproteinsignaltransductionproteinkinaseCsignalingRhoproteinsignaltransductionseminiferoustubuledevelopmentvascularendothelialgrowthfactorproduction
Tyrosine-protein kinase receptor TYRO3
2.0
84
83
TYRO3TYRO3Q06418Q06418apoptoticcellclearancecelladhesioncellmigrationestablishmentoflocalizationincellforebraincellmigrationnaturalkillercelldifferentiationnegativeregulationofinflammatoryresponsenegativeregulationofinnateimmuneresponsenegativeregulationoflymphocyteactivationnegativeregulationofneuronapoptoticprocessnegativeregulationoftoll-likereceptorsignalingpathwaynervoussystemdevelopmentneuronapoptoticprocessneuroncellularhomeostasisneuronmigrationneuropeptidesignalingpathwayovulationcyclephagocytosisphosphatidylinositol3-kinasesignalingplateletactivationplateletaggregationpositiveregulationofkinaseactivitypositiveregulationofvirallifecycleproteinautophosphorylationproteinkinaseBsignalingsecretionbycellsignaltransductionspermatogenesissubstrateadhesion-dependentcellspreadingtransmembranereceptorproteintyrosinekinasesignalingpathwayvaginadevelopment
Protein kinase C and casein kinase substrate in neurons protein 1
8.9
53
47
PACN1PACN1Q9BY11Q9BY11actinfilamentorganizationcytoskeletonorganizationnegativeregulationofendocytosisneuronprojectionmorphogenesisplasmamembranetubulationpositiveregulationofdendritedevelopmentproteinlocalizationtomembraneproteinlocalizationtoplasmamembraneregulationofendocytosissynapticvesicleendocytosis
HAUS augmin-like complex subunit 1
8.9
59
43
✔
HAUS1HAUS3Q96CS2Q68CZ6celldivisioncentrosomecyclespindleassembly
Dual specificity protein phosphatase 22
5.0
72
67
DUS22DUS22Q9NRW4Q9NRW4cellularresponsetoepidermalgrowthfactorstimulusdephosphorylationnegativeregulationofcellmigrationnegativeregulationoffocaladhesionassemblynegativeregulationofnon-membranespanningproteintyrosinekinaseactivitynegativeregulationofTcellactivationnegativeregulationofTcellmediatedimmunitynegativeregulationofTcellreceptorsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-tyrosinedephosphorylationpositiveregulationofJNKcascaderegulationofcellpopulationproliferationsignaltransductiontransforminggrowthfactorbetareceptorsignalingpathway
Regulator of chromosome condensation
8.9
98
29
RCC1RCC1P18754P18754celldivisionchromosomesegregationG1/Stransitionofmitoticcellcyclemitoticnuclearmembranereassemblymitoticspindleorganizationregulationofmitoticnucleardivisionspindleassemblyviralprocess
AP-2 complex subunit sigma
2.0
74
81
Q4JGV0AP2S1Q4JGV0P62744mitigationofhostantiviraldefenseresponseclathrin-dependentendocytosisintracellularproteintransportpostsynapticneurotransmitterreceptorinternalizationsynapticvesicleendocytosisvesicle-mediatedtransport
Transcription termination factor 1, mitochondrial
8.9
58
41
MTEF1MTEF1Q99551Q99551DNAgeometricchangeDNA-templatedtranscriptionterminationregulationofDNA-templatedtranscriptionterminationofmitochondrialtranscription
Beta-catenin-like protein 1
8.9
79
31
CTBL1CTBL1Q8WYA6Q8WYA6adaptiveimmuneresponsemRNAsplicingviaspliceosomepositiveregulationofapoptoticprocesssomaticdiversificationofimmunoglobulins
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
8.9
88
28
PAPS2PAPS2O95340O95340"3-phosphoadenosine5-phosphosulfatebiosyntheticprocess"bloodcoagulationbonedevelopmenthormonemetabolicprocessphosphorylationsulfateassimilation
RNA polymerase-associated protein CTR9 homolog
9.9
56
40
CTR9SKI8Q6PD62Q9GZS3blastocystgrowthblastocysthatchingcellularresponsetolipopolysaccharideendodermalcellfatecommitmenthistoneH2BubiquitinationhistoneH3-K4trimethylationhistonemonoubiquitinationinnercellmasscelldifferentiationinterleukin-6-mediatedsignalingpathwaynegativeregulationofmyeloidcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K79methylationreceptorsignalingpathwayviaJAK-STATregulationofgeneticimprintingregulationofhistoneH3-K4methylationstemcellpopulationmaintenancetranscriptionelongationbyRNApolymeraseIIpromotertrophectodermalcelldifferentiationWntsignalingpathwayhistoneH3-K4methylation
Death domain associated protein
8.9
77
36
Q4VX54Q4VX54Q4VX54Q4VX54
Hemoglobin subunit alpha
9.7
74
31
HBAHBAP60523P60523
Gonadotropin-releasing hormone receptor
1.9
72
83
GNRHRGNRHRP30968P30968Gprotein-coupledreceptorsignalingpathwaygonadotropinsecretion
Aldo-keto reductase family 1 member C3
8.9
76
34
AK1C3AK1C3P42330P42330cellularresponsetocadmiumioncellularresponsetocalciumioncellularresponsetocorticosteroidstimuluscellularresponsetojasmonicacidstimuluscellularresponsetoprostaglandinDstimuluscellularresponsetoprostaglandinstimuluscellularresponsetoreactiveoxygenspeciescellularresponsetostarvationcyclooxygenasepathwaydaunorubicinmetabolicprocessdoxorubicinmetabolicprocessfarnesolcatabolicprocessGprotein-coupledreceptorsignalingpathwaykeratinocytedifferentiationmacromoleculemetabolicprocessmalegonaddevelopmentnegativeregulationofretinoicacidbiosyntheticprocesspositiveregulationofcelldeathpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationofreactiveoxygenspeciesmetabolicprocessprogesteronemetabolicprocessprostaglandinmetabolicprocessregulationofretinoicacidreceptorsignalingpathwayregulationoftestosteronebiosyntheticprocessrenalabsorptionresponsetonutrientretinalmetabolicprocessretinoidmetabolicprocesssteroidmetabolicprocesstestosteronebiosyntheticprocess
Receptor-type tyrosine-protein phosphatase U
9.3
67
42
PTPRUPTPRUQ92729Q92729animalorganregenerationcelladhesioncelldifferentiationhomotypiccell-celladhesionnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationpositiveregulationofcell-celladhesionmediatedbycadherinproteindephosphorylationproteinlocalizationtocellsurfaceresponsetoglucocorticoidtransmembranereceptorproteintyrosinephosphatasesignalingpathway
DCN1-like protein 2
8.9
64
39
DCNL2DCNL2Q6PH85Q6PH85positiveregulationofproteinneddylationpositiveregulationofubiquitin-proteintransferaseactivityproteinneddylationregulationofproteinneddylation
DNA repair endonuclease XPF
9.7
60
39
XPFXPFQ92889Q92889cellularresponsetoUVDNArepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningnegativeregulationofdouble-strandedtelomericDNAbindingnegativeregulationofprotectionfromnon-homologousendjoiningattelomerenegativeregulationoftelomeremaintenancenegativeregulationoftelomeremaintenanceviatelomerelengtheningnucleotide-excisionrepairnucleotide-excisionrepairinvolvedininterstrandcross-linkrepair"nucleotide-excisionrepairDNAincision3-tolesion""nucleotide-excisionrepairDNAincision5-tolesion"regulationofautophagyresolutionofmeioticrecombinationintermediatesresponsetoUVtelomeremaintenancetelomericDNA-containingdoubleminutesformationUVprotection
Acetyl-CoA carboxylase 2
8.9
82
29
ACACBACACBQ6KE87Q6KE87acetyl-CoAmetabolicprocessenergyhomeostasisfattyacidbiosyntheticprocessmalonyl-CoAbiosyntheticprocessnegativeregulationofcatalyticactivitynegativeregulationoffattyacidbeta-oxidationnegativeregulationofgeneexpressionpositiveregulationofheartgrowthpositiveregulationoflipidstorageproteinhomotetramerizationregulationofglucosemetabolicprocessresponsetonutrientlevelsresponsetoorganiccycliccompoundresponsetoxenobioticstimulus
Carnitine O-acetyltransferase
9.9
78
35
CACPCACPQ3V1Y3Q3V1Y3carnitinemetabolicprocessCoA-linkedfattyacidbeta-oxidationusingacyl-CoAoxidasefattyacidmetabolicprocessmedium-chainfattyacidmetabolicprocessshort-chainfattyacidmetabolicprocess
Aldo-keto reductase family 1 member C1
9.0
78
33
AK1C1AK1C1Q04828Q04828bileacidandbilesalttransportbileacidmetabolicprocesscellularresponsetojasmonicacidstimuluscholesterolhomeostasisdaunorubicinmetabolicprocessdigestiondoxorubicinmetabolicprocessepithelialcelldifferentiationintestinalcholesterolabsorptionpositiveregulationofreactiveoxygenspeciesmetabolicprocessprogesteronemetabolicprocessprostaglandinmetabolicprocessresponsetoorganophosphorusretinalmetabolicprocessretinoidmetabolicprocesssteroidmetabolicprocessxenobioticmetabolicprocess
Splicing factor 3B subunit 3
9.2
88
34
SF3B3SF3B3Q15393Q15393histoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationmRNAsplicingviaspliceosomenegativeregulationofproteincatabolicprocesspositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingRNAsplicingRNAsplicingviatransesterificationreactionsU2-typeprespliceosomeassembly
Cytochrome P450
9.0
71
37
J9JD66J9JD66J9JD66J9JD66
Beta-arrestin-1
9.6
77
34
ARRB1ARRB1P29066P29066adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayendocytosisfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwaynegativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofERK1andERK2cascadenegativeregulationofGTPaseactivitynegativeregulationofinterleukin-6productionnegativeregulationofinterleukin-8productionnegativeregulationofneuronapoptoticprocessnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNotchsignalingpathwaynegativeregulationofproteinphosphorylationnegativeregulationofproteinubiquitinationphototransductionpositiveregulationofcellpopulationproliferationpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofhistoneacetylationpositiveregulationofhistoneH4acetylationpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofMAPKcascadepositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofreceptorinternalizationpositiveregulationofRhoproteinsignaltransductionpositiveregulationofsmoothmusclecellapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteintransportproteinubiquitinationregulationofapoptoticprocessregulationofDNA-templatedtranscriptionregulationofGprotein-coupledreceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulussensoryperceptionofpainsensoryperceptionoftouchstressfiberassemblyubiquitin-dependentproteincatabolicprocess
BCL-6 corepressor-like protein 1
9.0
63
41
BCORLBCORLQ5H9F3Q5H9F3chromatinorganizationnegativeregulationoftranscriptionbyRNApolymeraseII
Cohesin subunit SA-2
6.5
74
48
STAG2STAG2Q8N3U4Q8N3U4celldivisionestablishmentofmitoticsisterchromatidcohesionmeioticcellcyclemitoticspindleassemblysisterchromatidcohesion
Rho GTPase-activating protein 35
9.0
55
40
RHG35RHG35P81128P81128axonguidanceaxonalfasciculationcamera-typeeyedevelopmentcellmigrationcellularresponsetoextracellularstimuluscentralnervoussystemneuronaxonogenesisestablishmentormaintenanceofactincytoskeletonpolarityforebraindevelopmentmammaryglanddevelopmentnegativeregulationofRhoproteinsignaltransductionnegativeregulationofvascularpermeabilityneuraltubeclosureneuronprojectionguidancepositiveregulationofciliumassemblypositiveregulationofGTPaseactivitypositiveregulationofneuronprojectiondevelopmentregulationofactincytoskeletonorganizationregulationofactinpolymerizationordepolymerizationregulationofaxonogenesisregulationofcellshaperegulationofcellsizeRhoproteinsignaltransductionwoundhealingspreadingofcells
Interleukin-18
3.7
75
72
IL18IL18Q14116Q14116activationofproteinkinaseBactivityangiogenesiscellpopulationproliferationcell-cellsignalingcellularresponsetoorganiccycliccompoundcholesterolhomeostasisdefenseresponsetoGram-positivebacteriumestablishmentofskinbarrierinflammatoryresponseinterleukin-18-mediatedsignalingpathwaylipopolysaccharide-mediatedsignalingpathwayMAPKcascadenaturalkillercellactivationnaturalkillercellmediatedcytotoxicitynegativeregulationofmyoblastdifferentiationneutrophilactivationNIK/NF-kappaBsignalingpositiveregulationofactivatedTcellproliferationpositiveregulationofchemokineproductionpositiveregulationofcold-inducedthermogenesispositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-13productionpositiveregulationofinterleukin-17productionpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofnaturalkillercellproliferationpositiveregulationofneuroinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofNKTcellproliferationpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofsmoothmusclecellproliferationpositiveregulationofT-helper1cellcytokineproductionpositiveregulationofT-helper2celldifferentiationpositiveregulationoftissueremodelingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinregulationofcelladhesionsleepT-helper1typeimmuneresponsetriglyceridehomeostasistype2immuneresponse
Interleukin-2 receptor subunit beta
2.0
nan
87
IL2RBIL2RBP14784P14784cytokine-mediatedsignalingpathwayinterleukin-15-mediatedsignalingpathwayinterleukin-2-mediatedsignalingpathwaynaturalkillercellactivationnegativeregulationofapoptoticprocesspositiveregulationofphagocytosisprotein-containingcomplexassemblysignaltransduction
Tyrosine-protein kinase receptor
9.0
65
44
J3KP20J3KP20J3KP20J3KP20celldifferentiationnervoussystemdevelopmenttransmembranereceptorproteintyrosinekinasesignalingpathway
DENN domain-containing protein 5A
8.9
64
44
DEN5ADEN5AQ6PAL8Q6PAL8negativeregulationofneuronprojectiondevelopmentretrogradetransportendosometoGolgi
Sentrin-specific protease 2
9.0
61
42
SENP2SENP2Q9HC62Q9HC62fatcelldifferentiationheartdevelopmentlabyrinthinelayerdevelopmentmRNAtransportnegativeregulationofchromatinbindingnegativeregulationofproteinubiquitinationpositiveregulationofproteinubiquitinationpositiveregulationoftranscriptionbyRNApolymeraseIIproteindestabilizationproteindesumoylationproteinsumoylationproteintransportregulationofDNAendoreduplicationregulationofG1/StransitionofmitoticcellcycleregulationofWntsignalingpathwayspongiotrophoblastlayerdevelopmenttrophoblastgiantcelldifferentiationWntsignalingpathway
Suppressor of cytokine signaling 4
9.0
71
38
SOCS4SOCS4Q8WXH5Q8WXH5intracellularsignaltransductionnegativeregulationofepidermalgrowthfactor-activatedreceptoractivityphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinubiquitination
Prefoldin subunit 3
9.7
66
33
PFD2PFD3Q9UHV9P61758negativeregulationofamyloidfibrilformationpositiveregulationofcytoskeletonorganizationproteinfoldingproteinstabilizationmicrotubule-basedprocesstubulincomplexassembly
Isoform Glur5-2 of Glutamate receptor ionotropic, kainate 1
2.0
39
87
GRIK1GRIK1P22756P22756adultbehaviorbehavioralresponsetopainchemicalsynaptictransmissionestablishmentoflocalizationincellexcitatorypostsynapticpotentialgamma-aminobutyricacidsecretioninhibitorypostsynapticpotentialionotropicglutamatereceptorsignalingpathwaymembranedepolarizationmodulationofchemicalsynaptictransmissionmodulationofexcitatorypostsynapticpotentialnegativeregulationofsynaptictransmissionGABAergicnegativeregulationofsynaptictransmissionglutamatergicnervoussystemdevelopmentpositiveregulationofgamma-aminobutyricacidsecretionpositiveregulationofsynaptictransmissionGABAergicpotassiumiontransmembranetransportpresynapticmodulationofchemicalsynaptictransmissionregulationofmembranepotentialregulationofshort-termneuronalsynapticplasticityregulationofsynapticplasticitysodiumiontransmembranetransportsynaptictransmissionGABAergicsynaptictransmissionglutamatergic
Myoneurin
9.0
54
47
MYNNMYNNQ9NPC7Q9NPC7cellularresponsetoleukemiainhibitoryfactorregulationoftranscriptionbyRNApolymeraseII
RWD domain-containing protein 2A
9.0
65
42
RWD2ARWD2AQ9UIY3Q9UIY3
Coatomer subunit delta
9.0
64
44
COPDCOPDP53619P53619adultlocomotorybehaviorcerebellarPurkinjecelllayermaturationendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgilocalizationintra-Golgivesicle-mediatedtransportpigmentationproteintransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Actin nucleation-promoting factor WASL
9.0
40
49
WASLWASLO08816O08816actincytoskeletonorganizationactinfilamentpolymerizationactinfilament-basedmovementcelldivisiondendriticspinemorphogenesismembraneinvaginationnegativeregulationoflymphocytemigrationnegativeregulationofmembranetubulationplasmamembranetubulationpositiveregulationofchemotaxispositiveregulationofclathrin-dependentendocytosispositiveregulationoffilopodiumassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpostsynapseorganizationpostsynapticactincytoskeletonorganizationprotein-containingcomplexlocalizationregulationofcellprojectionassemblyregulationofpostsynapseorganizationregulationofproteinlocalizationresponsetobacteriumspindlelocalizationvesiclebuddingfrommembranevesicleorganizationvesicletransportalongactinfilament
Ribulose-phosphate 3-epimerase
5.0
70
73
RPERPEQ96AT9Q96AT9carbohydratemetabolicprocesscellularcarbohydratemetabolicprocesspentose-phosphateshuntpentose-phosphateshuntnon-oxidativebranch
Vinculin
9.0
78
36
VINCVINCP18206P18206adherensjunctionassemblyapicaljunctionassemblyaxonextensioncelladhesioncell-matrixadhesionepithelialcell-celladhesionlamellipodiumassemblymaintenanceofblood-brainbarriermorphogenesisofanepitheliumnegativeregulationofcellmigrationplateletaggregationproteinlocalizationtocellsurfaceregulationofestablishmentofendothelialbarrierregulationoffocaladhesionassemblyregulationofproteinlocalizationtoadherensjunction
PWWP domain-containing DNA repair factor 3A
9.0
56
41
PWP3APWP3AQ2TAK8Q2TAK8chromatinorganizationDNArepair
Islet amyloid polypeptide
2.0
21
87
IAPPIAPPP12969P12969adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayamylinreceptorsignalingpathwayboneresorptioneatingbehaviorglucosemetabolicprocessnegativeregulationofboneresorptionnegativeregulationofcelldifferentiationnegativeregulationofosteoclastdifferentiationosteoclastdifferentiationsensoryperceptionofpain
NEDD8-conjugating enzyme UBE2F
9.0
49
47
UBE2FUBE2FQ969M7Q969M7post-translationalproteinmodificationproteinneddylation
Glutamate dehydrogenase 1, mitochondrial
9.0
74
33
DHE3DHE3P00367P00367glutamatebiosyntheticprocessglutamatecatabolicprocessglutaminemetabolicprocesspositiveregulationofinsulinsecretionsubstantianigradevelopmenttricarboxylicacidmetabolicprocess
Ion channel TACAN
7.0
44
62
TACANTACANQ8C1E7Q8C1E7detectionofmechanicalstimulusinvolvedinsensoryperceptionofpainfatcelldifferentiationiontransmembranetransportproteinheterooligomerizationproteinhomooligomerization
Gephyrin
9.0
80
35
GEPHGEPHQ9NQX3Q9NQX3establishmentofsynapticspecificityatneuromuscularjunctiongamma-aminobutyricacidreceptorclusteringglycinereceptorclusteringMo-molybdopterincofactorbiosyntheticprocessmolybdenumincorporationintomolybdenum-molybdopterincomplexmolybdopterincofactorbiosyntheticprocesspostsynapticneurotransmitterreceptordiffusiontrappingresponsetometalion
Alpha-globin
9.0
69
37
A4ZQ87A4ZQ87A4ZQ87A4ZQ87
40S ribosomal protein S20
9.0
50
38
G1SIZ2G1U7M4G1SIZ2G1U7M4translation
Chromodomain-helicase-DNA-binding protein 1-like
9.0
53
44
✔
CHD1LCHD1LQ86WJ1Q86WJ1cellularresponsetoDNAdamagestimuluschromatinremodelingDNArepair
Dedicator of cytokinesis protein 10
9.2
73
37
DOC10DOC10Q96BY6Q96BY6BcellhomeostasisdendriticspinemorphogenesismarginalzoneBcelldifferentiationpositiveregulationofGTPaseactivityregulationofcellmigrationsmallGTPasemediatedsignaltransduction
Peroxisomal targeting signal 1 receptor
9.0
79
31
PEX5PEX5P50542P50542celldevelopmentcerebralcortexcellmigrationcerebralcortexneurondifferentiationendoplasmicreticulumorganizationfattyacidbeta-oxidationmitochondrialmembraneorganizationnegativeregulationofprotein-containingcomplexassemblyneuromuscularprocessneuronmigrationpexophagypositiveregulationofmulticellularorganismgrowthproteinimportintoperoxisomematrixproteinimportintoperoxisomematrixdockingproteinimportintoperoxisomematrixreceptorrecyclingproteinimportintoperoxisomematrixsubstratereleaseproteinimportintoperoxisomematrixtranslocationproteinimportintoperoxisomemembraneproteintargetingtoperoxisomeproteintetramerizationverylong-chainfattyacidmetabolicprocess
COP9 signalosome complex subunit 4
9.0
81
33
CSN4CSN7BQ9BT78Q9H9Q2proteindeneddylationproteinneddylationregulationofproteinneddylationCOP9signalosomeassembly
Tumor necrosis factor ligand superfamily member 12
2.0
62
82
TNF12TNF12O43508O43508angiogenesisapoptoticprocessapoptoticsignalingpathwaycelldifferentiationendothelialcellmigrationextrinsicapoptoticsignalingpathwayimmuneresponsepositiveregulationofangiogenesispositiveregulationofendothelialcellproliferationpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofproteincatabolicprocesssignaltransduction
Unconventional myosin-Ic
9.0
85
38
MYO1CMYO1CO00159O00159actinfilamentorganizationcellularresponsetotypeIIinterferonchromatinremodelingpositiveregulationofcellmigrationpositiveregulationofcellmigrationbyvascularendothelialgrowthfactorsignalingpathwaypositiveregulationofcellularresponsetoinsulinstimuluspositiveregulationofhistoneacetylationpositiveregulationofproteintargetingtomembranepositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationofvascularendothelialgrowthfactorsignalingpathwayproteintargetingtomembraneregulationofbicellulartightjunctionassemblyvesicletransportalongactinfilament
GSK3B-interacting protein
9.0
61
48
GSKIPGSKIPQ9P0R6Q9P0R6intrinsicapoptoticsignalingpathwayinresponsetooxidativestressnegativeregulationofproteinkinaseactivitypositiveregulationofcanonicalWntsignalingpathwayregulationofWntsignalingpathway
Peptidyl-tRNA hydrolase 2, mitochondrial
9.0
110
25
PTH2PTH2Q9Y3E5Q9Y3E5apoptoticprocessnegativeregulationofanoikisnegativeregulationofgeneexpressionpositiveregulationofanoikis
Beta-arrestin-2
9.0
65
34
ARRB2ARRB2P29067P29067adultwalkingbehaviorbraindevelopmentcellchemotaxisdesensitizationofGprotein-coupledreceptorsignalingpathwaybyarrestindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainendocytosisfollicle-stimulatinghormonesignalingpathwayGprotein-coupledreceptorinternalizationGprotein-coupledreceptorsignalingpathwaymodulationofchemicalsynaptictransmissionnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofGTPaseactivitynegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-12productionnegativeregulationofinterleukin-6productionnegativeregulationofnaturalkillercellmediatedcytotoxicitynegativeregulationofneuronapoptoticprocessnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteinphosphorylationnegativeregulationofproteinubiquitinationnegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationofsmoothmusclecellapoptoticprocessnegativeregulationoftoll-likereceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionpositiveregulationofcalciumiontransportpositiveregulationofcardiacmusclecelldifferentiationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNAbiosyntheticprocesspositiveregulationofepithelialcellapoptoticprocesspositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofreceptorinternalizationpositiveregulationofsynaptictransmissiondopaminergicpostsynapticsignaltransductionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteintransportproteinubiquitinationreceptorinternalizationregulationofGprotein-coupledreceptorsignalingpathwayregulationofproteinphosphorylationtranscriptionbyRNApolymeraseIItransforminggrowthfactorbetareceptorsignalingpathway
KN motif and ankyrin repeat domain-containing protein 2
9.0
69
45
KANK2KANK2Q63ZY3Q63ZY3apoptoticprocesskidneyepitheliumdevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationofprogrammedcelldeathnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvitaminDreceptorsignalingpathwaypodocytecellmigrationregulationofRhoproteinsignaltransduction
Mitochondrial import receptor subunit TOM70
9.0
61
41
TOM70TOM70O94826O94826activationofinnateimmuneresponsecellularresponsetovirusnegativeregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofinterferon-betaproductionpositiveregulationofproteinimportproteinimportintomitochondrialmatrixproteininsertionintomitochondrialinnermembraneproteininsertionintomitochondrialoutermembraneproteintargetingtomitochondrionregulationofapoptoticprocessresponsetothyroxine
Decapping and exoribonuclease protein
4.1
79
68
DXODXOO70348O70348mRNAcatabolicprocessNAD-capdecappingnuclearmRNAsurveillancenuclear-transcribedmRNAcatabolicprocessnucleicacidphosphodiesterbondhydrolysisRNAdestabilization
Alpha-globin
9.0
69
37
A4ZQ95A4ZQ95A4ZQ95A4ZQ95
Transcription elongation factor A protein 2
9.0
51
46
TCEA2TCEA2Q15560Q15560DNA-templatedtranscriptionDNA-templatedtranscriptionelongationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionelongationtranscriptionelongationbyRNApolymeraseIIpromoter
Regulator of microtubule dynamics protein 3
9.0
70
35
RMD3RMD3Q96TC7Q96TC7apoptoticprocesscelldifferentiationcellularcalciumionhomeostasis
Acyl-coenzyme A thioesterase THEM4
9.1
82
35
THEM4THEM4Q5T1C6Q5T1C6fattyacidmetabolicprocessproteinkinaseBsignalingregulationofmitochondrialmembranepermeabilityinvolvedinapoptoticprocess
DnaJ homolog subfamily C member 1
9.1
65
47
DNJC1DNJC1Q96KC8Q96KC8negativeregulationofproteolysisproteinfoldingregulationofproteinsecretionregulationoftranslation
Cysteine dioxygenase type 1
9.7
62
38
CDO1CDO1Q16878Q16878cysteinemetabolicprocessinflammatoryresponseL-cysteinecatabolicprocesslactationresponsetoaminoacidresponsetocAMPresponsetoethanolresponsetoglucagonresponsetoglucocorticoidsulfuraminoacidbiosyntheticprocesstaurinebiosyntheticprocess
14 kDa phosphohistidine phosphatase
6.9
54
64
✔
PHP14PHP14Q9NRX4Q9NRX4negativeregulationofATPcitratesynthaseactivitynegativeregulationoflyaseactivitynegativeregulationofTcellreceptorsignalingpathwaypeptidyl-histidinedephosphorylationpositiveregulationofcellmotilityproteindephosphorylationregulationofactincytoskeletonreorganization
Microtubule-associated protein RP/EB family member 1
8.6
55
46
MARE1MARE3Q15691Q9UPY8attachmentofmitoticspindlemicrotubulestokinetochorecelldivisioncellmigrationestablishmentofmitoticspindleorientationmicrotubulebundleformationmicrotubulepolymerizationnegativeregulationofmicrotubulepolymerizationnon-motileciliumassemblypositiveregulationofmicrotubuleplus-endbindingpositiveregulationofmicrotubulepolymerizationproteinlocalizationproteinlocalizationtoastralmicrotubuleproteinlocalizationtocentrosomeproteinlocalizationtomicrotubuleregulationofmicrotubulepolymerizationordepolymerizationspindleassemblypositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofproteinkinaseactivityregulationofmicrotubulepolymerization
ATP synthase lipid-binding protein
9.1
87
34
F1RWF6F1RWF6F1RWF6F1RWF6protonmotiveforce-drivenATPsynthesis
Eukaryotic translation initiation factor 3 subunit K
9.1
76
34
G1T3L2G1T3L2G1T3L2G1T3L2formationofcytoplasmictranslationinitiationcomplexregulationoftranslationalinitiation
Citrate synthase, mitochondrial
2.0
nan
85
CISYCISYP00889P00889carbohydratemetabolicprocesscitratemetabolicprocesstricarboxylicacidcycle
Kynureninase
9.1
88
26
KYNUKYNUQ16719Q16719"denovoNADbiosyntheticprocessfromtryptophan"anthranilatemetabolicprocessL-kynureninecatabolicprocessNADbiosyntheticprocessquinolinatebiosyntheticprocessresponsetotypeIIinterferonresponsetovitaminB6tryptophancatabolicprocesstryptophancatabolicprocesstokynurenine
Endothelial PAS domain-containing protein 1
2.0
nan
86
✔
EPAS1VHLQ99814P40337angiogenesisbloodvesselremodelingcellularresponsetohypoxiaembryonicplacentadevelopmentepithelialcellmaturationerythrocytedifferentiationironionhomeostasislungdevelopmentmitochondrionorganizationmRNAtranscriptionbyRNApolymeraseIImyoblastfatecommitmentnorepinephrinemetabolicprocesspositiveregulationofcold-inducedthermogenesispositiveregulationoftranscriptionbyRNApolymeraseIIregulationofheartrateregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressresponsetohypoxiasignaltransductionsurfactanthomeostasisvisualperceptionamyloidfibrilformationcellmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofsignaltransductionnegativeregulationoftranscriptionelongationbyRNApolymeraseIInegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofcelldifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofubiquitin-dependentproteincatabolicprocessproteinstabilizationproteinubiquitinationproteolysisregulationofcellularresponsetohypoxiaregulationofDNA-templatedtranscriptionregulationofgeneexpressionselectiveautophagy
COP9 signalosome complex subunit 6
9.5
55
37
CSN6CSN7BQ7L5N1Q9H9Q2proteindeneddylationproteinneddylationregulationofproteinneddylationCOP9signalosomeassembly
DNA excision repair protein ERCC-6
9.1
68
37
ERCC6ERCC6Q03468Q03468base-excisionrepairchromatinremodelingDNAdamagecheckpointsignalingDNAprotectionDNArepairdouble-strandbreakrepairviaclassicalnonhomologousendjoiningintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageJNKcascademulticellularorganismgrowthnegativeregulationofdouble-strandbreakrepairvianonhomologousendjoiningneurogenesisneurondifferentiationneuronprojectiondevelopmentphotoreceptorcellmaintenancepositiveregulationofDNArepairpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofhistoneacetylationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIpyrimidinedimerrepairregulationofDNA-templatedtranscriptionelongationregulationoftranscriptionelongationbyRNApolymeraseIIresponsetogammaradiationresponsetooxidativestressresponsetosuperoxideresponsetotoxicsubstanceresponsetoUVresponsetoUV-BresponsetoX-raysinglestrandbreakrepairtranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseItranscription-couplednucleotide-excisionrepair
Ornithine decarboxylase
9.1
78
37
✔
DCORDCORP11926P11926cellpopulationproliferationkidneydevelopmentpolyaminemetabolicprocesspositiveregulationofcellpopulationproliferationputrescinebiosyntheticprocessfromornithineregulationofproteincatabolicprocessresponsetovirus
Dual specificity phosphatase 28
7.5
95
47
DUS28DUS28Q8BTR5Q8BTR5dephosphorylationproteindephosphorylation
Glutamate receptor ionotropic, kainate 3
2.0
nan
88
GRIK3GRIK3P42264P42264chemicalsynaptictransmissionGprotein-coupledglutamatereceptorsignalingpathwayglutamatereceptorsignalingpathwayiontransmembranetransportmodulationofchemicalsynaptictransmissionnegativeregulationofsynaptictransmissionglutamatergicregulationofmembranepotentialregulationofpresynapticmembranepotentialsynaptictransmissionglutamatergic
Uridine diphosphate glucose pyrophosphatase NUDT22
9.1
60
43
NUD22NUD22Q9BRQ3Q9BRQ3
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
9.1
73
35
MECRMECRQ9BV79Q9BV79fattyacidbiosyntheticprocessfattyacidmetabolicprocess
Dihydrodiol dehydrogenase
9.1
78
33
Q54A37Q54A37Q54A37Q54A37
Platelet factor 4 variant
2.1
48
87
PF4VPF4VP10720P10720antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidechemokine-mediatedsignalingpathwayinflammatoryresponseneutrophilchemotaxis
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
9.1
75
31
AADATAADATQ8N5Z0Q8N5Z02-oxoglutaratemetabolicprocessalpha-aminoacidmetabolicprocessbiosyntheticprocessglutamatemetabolicprocesskynureninemetabolicprocessL-lysinecatabolicprocesstoacetyl-CoAviasaccharopine
Rap1 GTPase-activating protein 1
9.1
52
45
RPGP1RPGP1P47736P47736activationofGTPaseactivityadaptiveimmuneresponsecellularresponsetoglialcellderivedneurotrophicfactornegativeregulationofGTPbindingnegativeregulationofmicrovillusassemblynegativeregulationofneurondifferentiationnegativeregulationofthyroidglandepithelialcellproliferationpositiveregulationofGTPaseactivityregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionsignaltransduction
V-type proton ATPase catalytic subunit A
9.1
62
39
✔
VATAQ5ZWW6P38606Q5ZWW6cellularironionhomeostasiscellularresponsetoincreasedoxygenlevelsendosomallumenacidificationGolgilumenacidificationintracellularpHreductionlysosomallumenacidificationprotontransmembranetransportregulationofmacroautophagysynapticvesiclelumenacidificationvacuolaracidification
Peptidyl-prolyl cis-trans isomerase FKBP8
9.1
70
39
FKBP8FKBP8Q14318Q14318apoptoticprocessBMPsignalingpathwaycamera-typeeyedevelopmentdorsal/ventralneuraltubepatterningintracellularsignaltransductionmulticellularorganismgrowthnegativeregulationofapoptoticprocessnegativeregulationofproteinphosphorylationneuronfatespecificationpositiveregulationofBMPsignalingpathwayproteinfoldingproteinlocalizationtomitochondrionregulationofautophagyofmitochondrionregulationofgeneexpressionsmoothenedsignalingpathway
Hemoglobin subunit zeta
9.1
86
29
HBAZHBBP02008P68871carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessoxygentransportpositiveregulationofcelldeathbloodvesseldiametermaintenancenitricoxidetransportplateletaggregationpositiveregulationofnitricoxidebiosyntheticprocessregulationofbloodpressurerenalabsorptionresponsetohydrogenperoxide
C-X-C motif chemokine 14
2.0
42
89
CXL14CXL14O95715O95715antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingchemotaxiskillingofcellsofanotherorganismsignaltransduction
Peptidyl-prolyl cis-trans isomerase FKBP4
9.1
75
32
FKBP4FKBP4Q02790Q02790androgenreceptorsignalingpathwaychaperone-mediatedproteinfoldingcopperiontransportembryoimplantationmalesexdifferentiationnegativeregulationofmicrotubulepolymerizationnegativeregulationofmicrotubulepolymerizationordepolymerizationnegativeregulationofneuronprojectiondevelopmentprostateglanddevelopmentproteinfoldingproteinpeptidyl-prolylisomerizationprotein-containingcomplexlocalizationsteroidhormonereceptorcomplexassembly
Anoctamin-6
3.8
35
83
ANO6ANO6Q6P9J9Q6P9J9activationofbloodcoagulationviaclottingcascadeblebassemblybloodcoagulationbonemineralizationinvolvedinbonematurationcalciumactivatedgalactosylceramidescramblingcalciumactivatedphosphatidylcholinescramblingcalciumactivatedphosphatidylserinescramblingcalciumactivatedphospholipidscramblingcalciumiontransmembranetransportcationtransportchloridetransmembranetransportchloridetransportdendriticcellchemotaxisestablishmentoflocalizationincellnegativeregulationofcellvolumephosphatidylserineexposureonbloodplateletphospholipidtranslocationplasmamembranephospholipidscramblingporecomplexassemblypositiveregulationofapoptoticprocesspositiveregulationofbonemineralizationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofiontransmembranetransportpositiveregulationofmonocytechemotaxispositiveregulationofphagocytosisengulfmentpositiveregulationofpotassiumionexportacrossplasmamembranepurinergicnucleotidereceptorsignalingpathwayregulationofpostsynapticmembranepotentialsodiumiontransmembranetransporttransmembranetransport
Bardet-Biedl syndrome 4 protein homolog
8.8
56
39
BBS4BBS4Q1JQ97Q1JQ97adultbehaviorbrainmorphogenesiscentrosomecyclecerebralcortexdevelopmentciliumassemblydendritedevelopmentfacedevelopmentfatcelldifferentiationfatpaddevelopmentgeneexpressionhippocampusdevelopmentmaintenanceofproteinlocationinnucleusmicrotubuleanchoringatcentrosomemitoticcytokinesisnegativeregulationofactinfilamentpolymerizationnegativeregulationofappetitebyleptin-mediatedsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofGTPaseactivitynegativeregulationofsystemicarterialbloodpressureneuraltubeclosureneuronmigrationnon-motileciliumassemblyphotoreceptorcellmaintenancephotoreceptorcelloutersegmentorganizationpositiveregulationofciliumassemblypositiveregulationofmulticellularorganismgrowthproteinlocalizationtocentrosomeproteinlocalizationtociliumproteinlocalizationtophotoreceptoroutersegmentproteintransportregulationofciliumbeatfrequencyinvolvedinciliarymotilityregulationofcytokinesisregulationoflipidmetabolicprocessregulationofnon-motileciliumassemblyregulationofstressfiberassemblyretinalrodcelldevelopmentsensoryperceptionofsmellsocialbehaviorspermatiddevelopmentstriatumdevelopmentventricularsystemdevelopment
Potassium channel subfamily K member 3
9.2
68
38
KCNK3KCNK3O14649O14649braindevelopmentcellularresponsetohypoxiacellularresponsetozincionchemicalsynaptictransmissioncochleadevelopmentiontransmembranetransportnegativeregulationofcytosoliccalciumionconcentrationpositiveregulationofvoltage-gatedpotassiumchannelactivitypotassiumiontransmembranetransportpotassiumiontransportregulationofrestingmembranepotentialresponsetoxenobioticstimulusstabilizationofmembranepotential
Calcium and integrin-binding family member 3
9.2
70
40
CIB3CIB3Q96Q77Q96Q77calciumionhomeostasis
Activating signal cointegrator 1
9.2
67
39
TRIP4TRIP4Q15650Q15650intracellularestrogenreceptorsignalingpathwaypositiveregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscriptionregulationofmyoblastdifferentiationrescueofstalledribosomeribosomedisassemblyribosome-associatedubiquitin-dependentproteincatabolicprocesstoxintransport
Probable global transcription activator SNF2L2
9.2
47
47
✔
SMCA2SMCA2P51531P51531chromatinremodelingnegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIIspermatiddevelopment
Trafficking protein particle complex subunit 6B
9.2
74
32
TPC6BTPC6BQ86SZ2Q86SZ2endoplasmicreticulumtoGolgivesicle-mediatedtransportnervoussystemdevelopmentregulationofGTPaseactivityvesiclecoatingvesicletethering
ATP synthase lipid-binding protein
9.2
85
36
Q4VT52Q4VT52Q4VT52Q4VT52protonmotiveforce-drivenATPsynthesis
Exosome complex component RRP40
9.2
51
45
EXOS3EXOS3Q9NQT5Q9NQT5CUTcatabolicprocessDNAdeaminationexonucleolyticcatabolismofdeadenylatedmRNA"exonucleolytictrimmingtogeneratemature3-endof5.8SrRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)"isotypeswitchingnuclearpolyadenylation-dependentrRNAcatabolicprocessnuclearpolyadenylation-dependenttRNAcatabolicprocess"nuclear-transcribedmRNAcatabolicprocessexonucleolytic3-5""polyadenylation-dependentsnoRNA3-endprocessing"positiveregulationofisotypeswitchingRNAcatabolicprocessRNAprocessingrRNAprocessing"U4snRNA3-endprocessing"
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
9.2
68
37
SHIP2SHIP2O15357O15357actinfilamentorganizationcelladhesionendochondralossificationendocytosisestablishmentofmitoticspindleorientationglucosemetabolicprocessimmunesystemprocessnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofinsulin-likegrowthfactorreceptorsignalingpathwayphosphatidylinositolbiosyntheticprocessphosphatidylinositoldephosphorylationpost-embryonicdevelopmentregulationofactinfilamentorganizationregulationofimmuneresponseregulationofproteinlocalizationregulationofsignaltransductionresponsetoinsulinruffleassembly
DNA polymerase zeta catalytic subunit
8.1
64
45
REV3LREV3LO60673O60673DNA-templatedDNAreplicationdouble-strandbreakrepairviahomologousrecombinationerror-pronetranslesionsynthesis
Ras-related protein Rab-35
9.2
62
38
RAB35RAB35Q15286Q15286antigenprocessingandpresentationcellularresponsetonervegrowthfactorstimulusendocyticrecyclingendosomaltransportmitoticcytokinesisneuronprojectiondevelopmentplasmamembranetoendosometransportproteinlocalizationproteinlocalizationtoendosomeproteintransportRabproteinsignaltransductionvesicle-mediatedtransport
Microtubule-associated protein tau
4.9
65
68
✔
TAUTAUP10636P10636activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessamyloidfibrilformationastrocyteactivationaxondevelopmentaxonaltransportaxonaltransportofmitochondrioncell-cellsignalingcellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetoheatcellularresponsetonervegrowthfactorstimuluscellularresponsetoreactiveoxygenspeciescentralnervoussystemneurondevelopmentcytoplasmicmicrotubuleorganizationgenerationofneuronsinternalproteinaminoacidacetylationintracellulardistributionofmitochondrialearningormemorymemorymicroglialcellactivationmicrotubulecytoskeletonorganizationmicrotubulepolymerizationnegativeregulationofestablishmentofproteinlocalizationtomitochondrionnegativeregulationofgeneexpressionnegativeregulationofkinaseactivitynegativeregulationofmitochondrialfissionnegativeregulationofmitochondrialmembranepotentialnegativeregulationoftubulindeacetylationneurofibrillarytangleassemblyneuronprojectiondevelopmentplus-end-directedorganelletransportalongmicrotubulepositiveregulationofaxonextensionpositiveregulationofdiacylglycerolkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofneurondeathpositiveregulationofproteinlocalizationpositiveregulationofproteinlocalizationtosynapsepositiveregulationofsuperoxideaniongenerationproteinhomooligomerizationproteinpolymerizationregulationofautophagyregulationofcalcium-mediatedsignalingregulationofcellularresponsetoheatregulationofchromosomeorganizationregulationoflong-termsynapticdepressionregulationofmicrotubulecytoskeletonorganizationregulationofmicrotubulepolymerizationregulationofmicrotubulepolymerizationordepolymerizationregulationofmitochondrialfissionregulationofresponsetoDNAdamagestimulusregulationofsynapticplasticityresponsetoleadionrRNAmetabolicprocessstressgranuleassemblysupramolecularfiberorganizationsynapseassemblysynapseorganization
Cyclin-dependent kinase 2-associated protein 2
9.2
75
35
CDKA2CDKA2O75956O75956negativeregulationofG1/Stransitionofmitoticcellcycleregulationofmicrotubulecytoskeletonorganizationregulationofstemcelldivision
Prolyl hydroxylase EGLN2
4.0
57
70
EGLN2EGLN2Q96KS0Q96KS0cellredoxhomeostasiscellularresponsetohypoxiaintracellularestrogenreceptorsignalingpathwaypeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationofproteincatabolicprocessregulationofcellgrowthregulationofneuronapoptoticprocessresponsetohypoxia
DNA replication complex GINS protein PSF1
6.4
77
55
PSF1PSF1Q14691Q14691DNAstrandelongationinvolvedinmitoticDNAreplicationDNAunwindinginvolvedinDNAreplicationinnercellmasscellproliferationpositiveregulationofDNAprimaseactivitypositiveregulationofDNA-directedDNApolymeraseactivity
Transcription elongation factor SPT5
9.2
65
43
✔
SPT5HSPT5HO00267O00267negativeregulationofDNA-templatedtranscriptionelongationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationofmacroautophagypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionelongationbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromotertranscriptionelongation-coupledchromatinremodeling
GDP-mannose 4,6 dehydratase
9.2
63
36
GMDSGMDSO60547O60547"denovoGDP-L-fucosebiosyntheticprocess"GDP-mannosemetabolicprocessNotchsignalingpathway
Equilibrative nucleoside transporter 1
9.9
78
28
S29A1S29A1Q99808Q99808adenosinetransportcellularresponsetoglucosestimuluscellularresponsetohypoxiaexcitatorypostsynapticpotentiallactationneurotransmittertransportneurotransmitteruptakenucleobase-containingcompoundmetabolicprocessnucleosidetransmembranetransportnucleosidetransportpurinenucleosidetransmembranetransportpyrimidine-containingcompoundtransmembranetransportsleeptransportacrossblood-brainbarrieruridinetransportxenobioticmetabolicprocessxenobiotictransmembranetransport
Glutamate receptor 3
2.0
nan
91
GRIA3GRIA3P19492P19492chemicalsynaptictransmissionchemicalsynaptictransmissionpostsynapticiontransmembranetransportregulationofpostsynapticmembranepotentialregulationofreceptorrecyclingresponsetofungicideresponsetolithiumion
Glutamate dehydrogenase 2, mitochondrial
9.2
78
41
DHE4DHE4P49448P49448glutamatebiosyntheticprocessglutamatecatabolicprocessglutamatemetabolicprocess
Vesicular glutamate transporter 2
6.3
37
70
VGLU2VGLU2Q9JI12Q9JI12aniontransportbraindevelopmenthippocampusdevelopmenthyaloidvascularplexusregressionL-glutamateimportL-glutamatetransmembranetransportneuralretinadevelopmentneurotransmitterloadingintosynapticvesicleneurotransmitteruptakephosphateionhomeostasisphosphateiontransportregulationofsynapsestructureoractivitysodium-dependentphosphatetransportsynaptictransmissionglutamatergic
Tyrosine-protein kinase ABL2
9.2
68
42
ABL2ABL2P42684P42684celladhesioncellularresponsetoretinoicacidexplorationbehaviornegativeregulationofRhoproteinsignaltransductionpeptidyl-tyrosinephosphorylationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofestablishmentofTcellpolaritypositiveregulationofneuronprojectiondevelopmentpositiveregulationofoxidoreductaseactivitypositiveregulationofphospholipaseCactivitypositiveregulationofTcellmigrationproteinmodificationprocessregulationofactincytoskeletonreorganizationregulationofautophagyregulationofcelladhesionregulationofcellmotilityregulationofendocytosissignaltransduction
asparaginase
9.2
72
32
H0W0T5H0W0T5H0W0T5H0W0T5aspartatefamilyaminoacidmetabolicprocess
Eukaryotic translation initiation factor 3 subunit J
9.3
68
42
✔
EIF3JEIF3JO75822O75822formationofcytoplasmictranslationinitiationcomplextranslationalinitiation
Protein tyrosine phosphatase type IVA 3
9.2
64
39
TP4A3TP4A3O75365O75365cellularresponsetoleukemiainhibitoryfactorendothelialcellmigrationNotchsignalingpathwaypositiveregulationofestablishmentofproteinlocalizationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofvascularpermeabilityproteindephosphorylationregulationofDNA-templatedtranscriptionregulationofvascularendothelialgrowthfactorsignalingpathway
Cystine/glutamate transporter
2.0
40
88
4F2XCTJ3KPF3Q9UPY5aminoacidtransportcalciumiontransportcarbohydratemetabolicprocessisoleucinetransportL-alanineimportacrossplasmamembraneL-histidinetransportL-leucineimportacrossplasmamembraneleucineimportacrossplasmamembraneleucinetransportmethioninetransportphenylalaninetransportprolinetransportresponsetoexogenousdsRNAthyroidhormonetransporttryptophantransporttyrosinetransportvalinetransportviralentryintohostcelladultbehaviorcellularglutamatehomeostasiscellularresponsetooxidativestressdipeptideimportacrossplasmamembraneglutathionemetabolicprocessglutathionetransmembranetransportL-cystinetransportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportL-kynureninetransmembranetransportlensfibercelldifferentiationlimbdevelopmentlungalveolusdevelopmentmodulationofchemicalsynaptictransmissionnegativeregulationofferroptosisnegativeregulationofoxidativestress-inducedneurondeathplateletaggregationregulationofAMPAglutamatereceptorclusteringregulationofcellpopulationproliferationregulationofcysteinemetabolicprocessregulationofglutamatemetabolicprocessregulationofglutathionebiosyntheticprocessregulationofmelaninbiosyntheticprocessregulationofneutrophilapoptoticprocessregulationofproteintransportregulationofsynapseorganizationresponsetonicotineresponsetoorganiccycliccompoundresponsetoredoxstateresponsetotoxicsubstancestriatumdevelopmentventricularsystemdevelopmentvisuallearning
ATP synthase F(0) complex subunit C2, mitochondrial
9.2
98
32
AT5G2AT5G2P07926P07926protonmotiveforce-drivenATPsynthesis
Dynactin subunit 4
9.2
68
31
DCTN4DCTN5A0A4X1TB62A0A286ZK88aortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
Replication factor C subunit 2
3.9
72
72
RFC2RFC2P35250P35250DNAduplexunwindingDNArepairDNA-templatedDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivity
Hematopoietic prostaglandin D synthase
9.2
51
39
HPGDSHPGDSO60760O60760glutathionemetabolicprocesslocomotorybehaviornegativeregulationofmalegermcellproliferationprostaglandinbiosyntheticprocessprostaglandinmetabolicprocesssignaltransduction
Protein mono-ADP-ribosyltransferase PARP3
9.2
73
31
PARP3PARP3Q9Y6F1Q9Y6F1DNAADP-ribosylationdouble-strandbreakrepairnegativeregulationofisotypeswitchingnegativeregulationoftelomeraseRNAreversetranscriptaseactivitypositiveregulationofDNAligationpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningproteinauto-ADP-ribosylationproteinlocalizationtositeofdouble-strandbreakregulationofmitoticspindleorganizationtelomeremaintenance
Peptidyl-prolyl cis-trans isomerase A
9.2
60
46
✔
PPIAPPIAP62937P62937activationofproteinkinaseBactivityapoptoticprocesscelladhesionmoleculeproductioncellularresponsetooxidativestressendothelialcellactivationleukocytechemotaxislipiddropletorganizationnegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteinK48-linkedubiquitinationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinphosphorylationnegativeregulationofstress-activatedMAPKcascadenegativeregulationofvirallifecycleneutrophilchemotaxisplateletactivationplateletaggregationpositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteindephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofviralgenomereplicationproteinfoldingproteinpeptidyl-prolylisomerizationregulationofapoptoticsignalingpathwayregulationofviralgenomereplicationviralreleasefromhostcell
Synembryn
8.6
65
40
GNAI1B1H241P10824B1H241adenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaynegativeregulationofsynaptictransmissionpositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaybasementmembraneorganizationcellmigrationinvolvedingastrulationcell-celladhesioninvolvedingastrulationinuteroembryonicdevelopmentvasculaturedevelopmentvisuallearning
Integrin-linked protein kinase
9.2
72
34
ILKILKQ13418Q13418branchinginvolvedinuretericbudmorphogenesiscellmorphogenesiscellprojectionorganizationcell-matrixadhesionestablishmentormaintenanceofepithelialcellapical/basalpolarityfibroblastmigrationintegrin-mediatedsignalingpathwaymyelinationinperipheralnervoussystemnegativeregulationofneuralprecursorcellproliferationnervedevelopmentneuralprecursorcellproliferationoutflowtractmorphogenesispeptidyl-serinephosphorylationplateletaggregationpositiveregulationofBMPsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofosteoblastdifferentiationpositiveregulationofphosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofsignaltransductionpositiveregulationofsubstrateadhesion-dependentcellspreadingproteinkinaseBsignalingproteinphosphorylationsubstrateadhesion-dependentcellspreadingtumornecrosisfactor-mediatedsignalingpathway
Unconventional myosin-VI
9.2
85
27
F1RQI7F1RQI7F1RQI7F1RQI7actinfilamentorganizationendocytosisinnerearauditoryreceptorcelldifferentiationinnerearmorphogenesissensoryperceptionofsoundvesicletransportalongactinfilament
Transmembrane protein 45A
9.3
60
31
TM45ATM45AQ9NWC5Q9NWC5
Septin-7
7.0
82
49
SEPT7SEPT7Q16181Q16181celldifferentiationciliumassemblycytoskeleton-dependentcytokinesispositiveregulationofnon-motileciliumassemblyregulationofembryoniccellshapespermatogenesis
CLIP-associating protein 2
9.3
95
26
CLAP2CLAP2O75122O75122celldivisionestablishmentofmitoticspindlelocalizationestablishmentormaintenanceofcellpolarityexitfrommitosisGolgiorganizationmicrotubuleanchoringmicrotubulecytoskeletonorganizationmicrotubulenucleationmicrotubuleorganizingcenterorganizationmitoticspindleassemblymitoticspindleorganizationnegativeregulationoffocaladhesionassemblynegativeregulationofmicrotubuledepolymerizationnegativeregulationofstressfiberassemblynegativeregulationofwoundhealingspreadingofepidermalcellsplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofbasementmembraneassemblyinvolvedinembryonicbodymorphogenesispositiveregulationofepithelialcellmigrationpositiveregulationofexocytosispositiveregulationofextracellularmatrixdisassemblyproteinlocalizationtoplasmamembraneregulationofactincytoskeletonorganizationregulationofaxonextensionregulationofepithelialtomesenchymaltransitionregulationofgastrulationregulationofmicrotubulepolymerizationregulationofmicrotubulepolymerizationordepolymerizationregulationofmicrotubule-basedprocessvesicletargeting
Conserved oligomeric Golgi complex subunit 4
9.3
66
37
COG4COG4Q9H9E3Q9H9E3glycosylationGolgiorganizationGolgivesicleprefusioncomplexstabilizationproteintransportretrogradetransportvesiclerecyclingwithinGolgiretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
Isoform I of Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
6.9
99
40
✔
SUCASUCAO19069-2O19069-2
Tubulin beta-2A chain
9.3
69
32
TBB2ATBB2AQ13885Q13885cerebralcortexdevelopmentmicrotubulecytoskeletonorganizationmitoticcellcycleneuronmigration
Histo-blood group ABO system transferase
9.3
68
33
BGATBGATP16442P16442carbohydratemetabolicprocesslipidglycosylationproteinglycosylation
Polyunsaturated fatty acid lipoxygenase ALOX15
4.3
75
71
LOX15LOX15P12530P12530apoptoticcellclearancearachidonicacidmetabolicprocessbonemineralizationcellularresponsetocalciumioncellularresponsetointerleukin-13fattyacidoxidationhepoxilinbiosyntheticprocesslinoleicacidmetabolicprocesslipidmetabolicprocesslipoxinA4biosyntheticprocesslipoxygenasepathwaynegativeregulationofadaptiveimmuneresponseossificationphosphatidylethanolaminebiosyntheticprocesspositiveregulationofactinfilamentpolymerizationpositiveregulationofcell-substrateadhesionpositiveregulationofERK1andERK2cascaderegulationofengulfmentofapoptoticcellregulationofinflammatoryresponseregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwayresponsetoendoplasmicreticulumstresswoundhealing
Transcription factor E2F4
9.3
57
43
E2F4E2F4Q16254Q16254animalorganmorphogenesisbloodcirculationcellvolumehomeostasiscentrioleassemblyepithelialcelldevelopmentmotileciliumassemblymulti-ciliatedepithelialcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellpopulationproliferationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptioninvolvedinG1/Stransitionofmitoticcellcycle
F-actin-capping protein subunit alpha
9.3
86
30
Q5RKN9Q5RKN9Q5RKN9Q5RKN9barbed-endactinfilamentcapping
Guanine nucleotide-binding protein G(i) subunit alpha-3
9.3
46
39
✔
GNAI3GNAI3P08754P08754adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaybraindevelopmentcellcyclecelldivisiondopaminereceptorsignalingpathwayGTPmetabolicprocessnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticsignalingpathwaypositiveregulationofmacroautophagypositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofsuperoxideaniongenerationpositiveregulationofvascularassociatedsmoothmusclecellproliferationvesiclefusion
Poly(rC)-binding protein 2
9.3
59
41
PCBP2PCBP2Q15366Q15366defenseresponsetovirusinnateimmuneresponseIRES-dependentviraltranslationalinitiationmRNAmetabolicprocessnegativeregulationofdefenseresponsetoviruspositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofgeneexpressionregulationofRNAmetabolicprocessviralRNAgenomereplication
Kinesin-like protein KIF7
9.3
86
31
KIF7KIF7Q2M1P5Q2M1P5microtubule-basedmovementnegativeregulationofsmoothenedsignalingpathwaypositiveregulationofsmoothenedsignalingpathway
Creatine kinase U-type, mitochondrial
9.3
76
33
✔
KCRUKCRUP12532P12532phosphocreatinebiosyntheticprocessphosphorylation
DNA topoisomerase 2-alpha
9.3
65
35
TOP2ATOP2AP11388P11388apoptoticchromosomecondensationcellularresponsetoDNAdamagestimuluschromosomesegregationDNAligationDNAtopologicalchangeembryoniccleavagefemalemeioticnucleardivisionhematopoieticprogenitorcelldifferentiationnegativeregulationofDNAduplexunwindingpositiveregulationofapoptoticprocesspositiveregulationofsinglestrandedviralRNAreplicationviadoublestrandedDNAintermediatepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcircadianrhythmresolutionofmeioticrecombinationintermediatesrhythmicprocesssisterchromatidsegregation
Spindle and kinetochore-associated protein 1
9.7
63
39
SKA1SKA2Q96BD8Q8WVK7celldivisionchromosomesegregationmitoticcellcycleregulationofmicrotubulepolymerizationordepolymerization
Cofilin-2
9.3
66
37
✔
COF2COF2Q9Y281Q9Y281actinfilamentdepolymerizationactinfilamentfragmentationactinfilamentseveringmusclecellcellularhomeostasispositiveregulationofactinfilamentdepolymerizationsarcomereorganizationskeletalmuscletissuedevelopment
Transient receptor potential cation channel subfamily M member 8
2.0
51
85
TRPM8TRPM8Q8R4D5Q8R4D5calciumiontransmembranetransportcalciumiontransportcationtransmembranetransportcellularcalciumionhomeostasispositiveregulationofcold-inducedthermogenesisresponsetocoldresponsetotemperaturestimulusthermoception
Serine/threonine-protein kinase TNNI3K
8.7
40
48
TNI3KTNI3KQ59H18Q59H18bundleofHiscelltoPurkinjemyocytecommunicationproteinphosphorylationregulationofcardiacconductionregulationofcardiacmusclecontractionregulationofheartrateregulationofpostsynapseorganization
Kinesin-like protein KIF1B
9.3
68
41
KIF1BKIF1BO60333O60333anterogradeaxonaltransportapoptoticprocesscytoskeleton-dependentintracellulartransportmicrotubule-basedmovementneuromuscularsynaptictransmissionneuron-neuronsynaptictransmissionvesicle-mediatedtransport
Zinc fingers and homeoboxes protein 3
9.3
26
49
ZHX3ZHX3Q9H4I2Q9H4I2celldifferentiationnegativeregulationofDNA-templatedtranscriptionpositiveregulationofosteoblastdifferentiationregulationoftranscriptionbyRNApolymeraseII
Transient receptor potential cation channel subfamily V member 2
2.0
65
84
TRPV2TRPV2Q9WUD2Q9WUD2calciumionimportacrossplasmamembranecalciumiontransmembranetransportcationtransmembranetransportnegativeregulationofcellpopulationproliferationpositiveregulationofaxonextensionpositiveregulationofcalciumionimportpositiveregulationofcold-inducedthermogenesisresponsetoheatresponsetotemperaturestimulus
Kazal domain-containing peptide
9.3
76
40
✔
Q1HRB8PLMNQ1HRB8P00747biologicalprocessinvolvedininteractionwithsymbiontbloodcoagulationextracellularmatrixdisassemblyfibrinolysisnegativeregulationofcellpopulationproliferationnegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofcell-substrateadhesionnegativeregulationoffibrinolysispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationoffibrinolysisproteolysistissueremodeling
Kinesin family member 13A
9.4
51
43
F8VQ75F8VQ75F8VQ75F8VQ75endosometolysosometransportintracellularproteintransportmelanosomeorganizationmicrotubule-basedmovementregulationofcytokinesisvesiclecargoloading
Nucleotide triphosphate diphosphatase NUDT15
6.6
65
49
NUD15NUD15Q9NV35Q9NV35dGTPcatabolicprocessDNAprotectionmitoticcellcyclenucleobase-containingsmallmoleculemetabolicprocessnucleosidephosphatecatabolicprocesspurinenucleotidecatabolicprocessregulationofproteasomalproteincatabolicprocessresponsetoreactiveoxygenspeciesxenobioticcatabolicprocess
EKC/KEOPS complex subunit TP53RK
9.4
86
30
PRPKTPRKBQ96S44Q9Y3C4proteinphosphorylationregulationofsignaltransductionbyp53classmediatortRNAprocessingtRNAthreonylcarbamoyladenosinemetabolicprocesstRNAthreonylcarbamoyladenosinemodification
Delta-1-pyrroline-5-carboxylate synthase
6.9
91
60
✔
P5CSP5CSP54886P54886citrullinebiosyntheticprocessglutamatemetabolicprocessL-prolinebiosyntheticprocessornithinebiosyntheticprocessphosphorylationprolinebiosyntheticprocess
Phosphatidylinositol glycan anchor biosynthesis class U protein
9.4
89
29
PIGUPIGUQ9H490Q9H490attachmentofGPIanchortoproteinGPIanchorbiosyntheticprocessproteinlocalizationtocellsurfaceregulationofreceptorsignalingpathwayviaJAK-STAT
Tripartite motif-containing protein 10
9.4
91
26
TRI10TRI10Q9UDY6Q9UDY6erythrocytedifferentiationinnateimmuneresponsenegativeregulationofviralentryintohostcellproteinubiquitinationregulationofgeneexpression
Gamma-tubulin complex component 2
6.5
62
51
GCP2GCP2Q9BSJ2Q9BSJ2braindevelopmentcytoplasmicmicrotubuleorganizationmeioticcellcyclemicrotubulenucleationmitoticcellcycleneuronmigrationprotein-containingcomplexassemblyspindleassembly
Pleckstrin
9.9
58
42
PLEKPLEKP08567P08567actincytoskeletonreorganizationcellprojectionorganizationcorticalactincytoskeletonorganizationhematopoieticprogenitorcelldifferentiationintegrin-mediatedsignalingpathwaynegativeregulationofcalcium-mediatedsignalingnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofinositolphosphatebiosyntheticprocessphosphatidylinositolmetabolicprocessphospholipaseC-inhibitingGprotein-coupledreceptorsignalingpathwayplateletaggregationplateletdegranulationpositiveregulationofactinfilamentbundleassemblypositiveregulationofactinfilamentdepolymerizationpositiveregulationofinositol-polyphosphate5-phosphataseactivitypositiveregulationofintegrinactivationpositiveregulationofplateletactivationproteinkinaseCsignalingproteinsecretionbyplateletregulationofcelldiameterruffleorganizationthrombin-activatedreceptorsignalingpathwayvesicledockinginvolvedinexocytosis
Cyclin-dependent kinase 8
9.4
74
32
CDK8CCNCP49336P24863proteinphosphorylationG0toG1transitionnegativeregulationofNotchsignalingpathwaypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Homeobox protein SIX1
9.4
80
29
SIX1SIX1Q15475Q15475aortamorphogenesisapoptoticprocessbranchinginvolvedinuretericbudmorphogenesis"cellularresponseto335-triiodo-L-thyronine"cochleamorphogenesisembryoniccranialskeletonmorphogenesisembryonicskeletalsystemmorphogenesisendothelinreceptorsignalingpathwayepithelialcelldifferentiationfacialnervemorphogenesisfungiformpapillamorphogenesisgenerationofneuronsinnereardevelopmentinnerearmorphogenesiskidneydevelopmentmesenchymalcellproliferationinvolvedinureterdevelopmentmesonephrictubuleformationmetanephricmesenchymedevelopmentmiddleearmorphogenesismyoblastmigrationmyoblastproliferationmyotomedevelopmentnegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcelldifferentiationneuronfatespecificationNotchsignalingpathwayolfactoryplacodeformationorganinductionoticvesicledevelopmentoutflowtractmorphogenesispatternspecificationprocesspharyngealsystemdevelopmentpositiveregulationofbranchinginvolvedinuretericbudmorphogenesispositiveregulationofbrownfatcelldifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofmesenchymalcellproliferationinvolvedinureterdevelopmentpositiveregulationofmyoblastproliferationpositiveregulationofsecondaryheartfieldcardioblastproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofuretericbudformationproteinlocalizationtonucleusregulationofbranchelongationinvolvedinuretericbudbranchingregulationofDNA-templatedtranscriptionregulationofepithelialcellproliferationregulationofneurondifferentiationregulationofproteinlocalizationregulationofskeletalmusclecelldifferentiationregulationofskeletalmusclecellproliferationregulationofskeletalmusclesatellitecellproliferationregulationofsynapticassemblyatneuromuscularjunctionregulationoftranscriptionbyRNApolymeraseIIsensoryperceptionofsoundskeletalmusclefiberdevelopmentskeletalmuscletissuedevelopmentthymusdevelopmentthyroidglanddevelopmenttrigeminalgangliondevelopmenturetersmoothmusclecelldifferentiationuretericbuddevelopment
Ras-specific guanine nucleotide-releasing factor 1
4.2
62
77
RGRF1RGRF1P27671P27671activationofGTPaseactivityneuronprojectiondevelopmentpositiveregulationoffibroblastproliferationpositiveregulationofGTPaseactivitypositiveregulationofRasproteinsignaltransductionRasproteinsignaltransductionregulationofneuronalsynapticplasticityregulationofNMDAreceptoractivityregulationofRacproteinsignaltransductionregulationofRasproteinsignaltransductionregulationofsynapticplasticityresponsetoendoplasmicreticulumstresstypeBpancreaticcellproliferation
Galectin
9.4
83
28
A0A0A7EMW6A0A0A7EMW6A0A0A7EMW6A0A0A7EMW6
Catenin delta-1
9.4
88
26
CTND1CTND1O60716O60716braindevelopmentcell-celladhesioncell-celladhesionmediatedbycadherincell-celljunctionassemblynegativeregulationofcanonicalWntsignalingpathwayproteinstabilizationregulationofpostsynapticmembraneneurotransmitterreceptorlevelsWntsignalingpathway
Arginase-2, mitochondrial
9.4
78
35
ARGI2ARGI2P78540P78540adaptiveimmuneresponseargininecatabolicprocesstoornithineinnateimmuneresponsenegativeregulationofactivatedCD8-positivealpha-betaTcellapoptoticprocessnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofchemokine(C-Cmotif)ligand4productionnegativeregulationofchemokine(C-Cmotif)ligand5productionnegativeregulationofdefenseresponsetobacteriumnegativeregulationofinterleukin-13productionnegativeregulationofinterleukin-17productionnegativeregulationofmacrophageinflammatoryprotein1alphaproductionnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftype2immuneresponsenitricoxidebiosyntheticprocesspositiveregulationofcellularsenescenceregulationofinterleukin-1betaproductionregulationofreactiveoxygenspeciesbiosyntheticprocessstriatedmusclecontractionureacycleuretericbuddevelopment
Aspartate--tRNA ligase, cytoplasmic
9.4
91
27
SYDCSYDCP14868P14868aspartyl-tRNAaminoacylationprotein-containingcomplexassemblytranslation
Cyclin-dependent kinase 5
9.4
77
30
CDK5CD5R1Q00535Q15078axonextensionaxonogenesisbehavioralresponsetococainecalciumionimportcelldivisioncell-matrixadhesioncellularresponsetoamyloid-betacentralnervoussystemneurondevelopmentcerebellarcortexformationchemicalsynaptictransmissioncorpuscallosumdevelopmentcorticalactincytoskeletonorganizationdendritemorphogenesisexcitatorypostsynapticpotentialhippocampusdevelopmentintracellularproteintransportlayerformationincerebralcortexmicrotubulecytoskeletonorganizationmitochondrionorganizationmotorneuronaxonguidancenegativeregulationofaxonextensionnegativeregulationofcellcyclenegativeregulationofDNA-templatedtranscriptionnegativeregulationofneurondeathnegativeregulationofproteinexportfromnucleusnegativeregulationofproteinubiquitinationnegativeregulationofproteolysisnegativeregulationofsynapticplasticityneuronapoptoticprocessneurondifferentiationneuronmigrationneuronprojectiondevelopmentnucleocytoplasmictransportoligodendrocytedifferentiationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationphosphorylationpositiveregulationofactincytoskeletonreorganizationpositiveregulationofcalciumion-dependentexocytosispositiveregulationofglialcellapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofpresynapticcytosoliccalciumconcentrationpositiveregulationofproteinbindingpositiveregulationofproteinkinaseactivitypositiveregulationofproteintargetingtomembranepositiveregulationofvoltage-gatedcalciumchannelactivityproteinautophosphorylationproteinlocalizationtosynapseproteinphosphorylationreceptorcatabolicprocessreceptorclusteringregulationofapoptoticprocessregulationofcellcycleregulationofcellmigrationregulationofdendriticspinemorphogenesisregulationofmacroautophagyregulationofpresynapticcytosoliccalciumionconcentrationregulationofproteinlocalizationtoplasmamembraneregulationofsynapsepruningregulationofsynapticplasticityregulationofsynaptictransmissionglutamatergicregulationofsynapticvesiclerecyclingregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcycleresponsetowoundingrhythmicprocessSchwanncelldevelopmentsensoryperceptionofpainserinephosphorylationofSTATproteinskeletalmuscletissuedevelopmentsynapseassemblysynaptictransmissiondopaminergicsynaptictransmissionglutamatergicsynapticvesicleendocytosissynapticvesicleexocytosissynapticvesicletransportvisuallearningaxonguidanceaxonalfasciculationbraindevelopmentcerebellumdevelopmentembryodevelopmentendinginbirthoregghatchingephrinreceptorsignalingpathwayGprotein-coupledacetylcholinereceptorsignalingpathwayG1toG0transitioninvolvedincelldifferentiationionotropicglutamatereceptorsignalingpathwayneuroncell-celladhesionpositiveregulationofMHCclassIIbiosyntheticprocesspositiveregulationofmicrotubulepolymerizationpositiveregulationofsignalingreceptoractivityregulationofactincytoskeletonorganizationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofneurondifferentiationregulationofsynapticvesiclecyclesuperiorolivarynucleusmaturation
ADP-ribosylation factor 6
9.4
73
30
ARF6ARF6P62330P62330celladhesioncellcyclecelldifferentiationcelldivisioncellularresponsetonervegrowthfactorstimuluscorticalactincytoskeletonorganizationendocyticrecyclingerythrocyteapoptoticprocessestablishmentofepithelialcellpolarityhepatocyteapoptoticprocessintracellularproteintransportliverdevelopmentmaintenanceofpostsynapticdensitystructurenegativeregulationofdendritedevelopmentnegativeregulationofproteinlocalizationtocellsurfacenegativeregulationofreceptor-mediatedendocytosisnervoussystemdevelopmentpositiveregulationofactinfilamentpolymerizationpositiveregulationoffocaladhesiondisassemblypositiveregulationofkeratinocytemigrationpositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinsecretionproteinlocalizationtocellsurfaceproteinlocalizationtoendosomeregulationofdendriticspinedevelopmentregulationoffilopodiumassemblyregulationofpresynapseassemblyregulationofRacproteinsignaltransductionruffleassemblysynapticvesicleendocytosisvesicle-mediatedtransport
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
9.4
37
45
ADPPTADPPTQ9P0Q3Q9P0Q310-formyltetrahydrofolatecatabolicprocesslysinebiosyntheticprocessviaaminoadipicacidpantothenatemetabolicprocessproteinmaturation
Immunoglobulin-binding protein 1
9.4
64
39
IGBP1IGBP1P78318P78318Bcellactivationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofstress-activatedMAPKcascadenegativeregulationoftranscriptionbyRNApolymeraseIIregulationofdephosphorylationregulationofmicrotubule-basedmovementresponsetointerleukin-1responsetotumornecrosisfactorsignaltransduction
Envelope protein US28
9.7
68
38
Q80KM9Q6I9S9Q80KM9Q6I9S9chemotaxisimmuneresponse
Eukaryotic translation initiation factor 4 gamma 3
8.2
nan
44
IF4G3IF4G3O43432O43432regulationoftranslationalinitiationtranslationalinitiation
Lysine (K)-specific demethylase 2A
9.4
69
33
F6YRW4F6YRW4F6YRW4F6YRW4chromatinorganizationcircadianregulationofgeneexpressiondouble-strandbreakrepairvianonhomologousendjoininghistoneH3-K36demethylationnegativeregulationoftranscriptionbycompetitivepromoterbindingregulationofcircadianrhythm
Hypoxanthine-guanine phosphoribosyltransferase
9.4
81
24
HPRTHPRTP00492P00492adeninemetabolicprocessAMPsalvagecentralnervoussystemneurondevelopmentcerebralcortexneurondifferentiationdendritemorphogenesisdopaminemetabolicprocessdopaminergicneurondifferentiationGMPcatabolicprocessGMPsalvagegroomingbehaviorguaninesalvagehypoxanthinemetabolicprocesshypoxanthinesalvageIMPmetabolicprocessIMPsalvagelocomotorybehaviorlymphocyteproliferationpositiveregulationofdopaminemetabolicprocessproteinhomotetramerizationpurinenucleotidebiosyntheticprocesspurineribonucleosidesalvageresponsetoamphetaminestriatumdevelopmentTcellmediatedcytotoxicity
Alpha-crystallin A chain
9.4
73
36
CRYAACRYAAP02489P02489lensdevelopmentincamera-typeeyenegativeregulationofapoptoticprocessnegativeregulationofintracellulartransportproteinrefoldingproteinstabilizationresponsetoheatvisualperception
Gamma-interferon-inducible protein 16
9.4
75
33
IF16IF16Q16666Q16666activationofcysteine-typeendopeptidaseactivityactivationofinnateimmuneresponseautophagycellularresponsetoglucosestarvationcellularresponsetointerferon-betacellularresponsetoionizingradiationdefenseresponsetovirusepigeneticregulationofgeneexpressioninflammatoryresponseinnateimmuneresponseintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatormonocytedifferentiationmyeloidcelldifferentiationnegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationofDNAbindingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofinnateimmuneresponsenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviralgenomereplicationpositiveregulationofcytokineproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofautophagy
Anoctamin-10
9.4
50
40
ANO10ANO10Q9NW15Q9NW15cationtransportchloridetransportiontransmembranetransporttransmembranetransport
von Hippel-Lindau disease tumor suppressor
2.0
nan
86
✔
EPAS1VHLQ99814P40337angiogenesisbloodvesselremodelingcellularresponsetohypoxiaembryonicplacentadevelopmentepithelialcellmaturationerythrocytedifferentiationironionhomeostasislungdevelopmentmitochondrionorganizationmRNAtranscriptionbyRNApolymeraseIImyoblastfatecommitmentnorepinephrinemetabolicprocesspositiveregulationofcold-inducedthermogenesispositiveregulationoftranscriptionbyRNApolymeraseIIregulationofheartrateregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressresponsetohypoxiasignaltransductionsurfactanthomeostasisvisualperceptionamyloidfibrilformationcellmorphogenesisnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofreceptorsignalingpathwayviaJAK-STATnegativeregulationofsignaltransductionnegativeregulationoftranscriptionelongationbyRNApolymeraseIInegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofcelldifferentiationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofubiquitin-dependentproteincatabolicprocessproteinstabilizationproteinubiquitinationproteolysisregulationofcellularresponsetohypoxiaregulationofDNA-templatedtranscriptionregulationofgeneexpressionselectiveautophagy
Ribonuclease P protein subunit p29
9.4
67
29
RPP29RPP29O95707O95707rRNAprocessing"tRNA5-leaderremoval"
Kinesin-like protein KIFC3
9.4
83
35
KIFC3KIFC3Q9BVG8Q9BVG8epithelialcell-celladhesionGolgiorganizationmicrotubule-basedmovementmicrotubule-basedprocessvisualperceptionzonulaadherensmaintenance
Anoctamin-1
2.0
73
82
ANO1ANO1Q8BHY3Q8BHY3cationtransportcellularresponsetoheatcellularresponsetopeptidechloridetransmembranetransportchloridetransportdetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainestablishmentoflocalizationincellglialcellprojectionelongationiodidetransportmucussecretionphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusproteinlocalizationtomembraneregulationofmembranepotentialtracheadevelopmenttransmembranetransport
Magnesium transporter protein 1
9.5
72
37
MAGT1MAGT1Q9H0U3Q9H0U3cognitionmagnesiumiontransportproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparaginetransmembranetransport
28S ribosomal protein S2, mitochondrial
9.5
66
32
RT02RT02Q9Y399Q9Y399mitochondrialribosomeassemblymitochondrialtranslation
Epidermal growth factor receptor substrate 15
9.5
63
39
EPS15EPS15P42566P42566clathrincoatassemblyendocyticrecyclingendocytosisendosomaltransportGolgitoendosometransportproteintransportreceptor-mediatedendocytosisofvirusbyhostcellvesicleorganizationviralentryintohostcell
Ferritin
6.0
52
60
Q6NS36Q6NS36Q6NS36Q6NS36cellularironionhomeostasisironiontransport
Cytoplasmic polyadenylation element-binding protein 3
9.5
51
45
CPEB3CPEB3Q8NE35Q8NE35"3-UTR-mediatedmRNAdestabilization"cellularresponsetoaminoacidstimuluslong-termmemorynegativeregulationofcytoplasmictranslationnegativeregulationofcytoplasmictranslationalelongationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranslationpositiveregulationofdendriticspinedevelopmentpositiveregulationofmRNApolyadenylationpositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationoftranslationregulationofdendriticspinedevelopmentregulationofsynapticplasticity
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
9.5
76
32
F262F262P26285P26285fructose26-bisphosphatemetabolicprocessfructosemetabolicprocessglycolyticprocess
Synapsin-2
6.9
85
44
SYN2SYN2Q63537Q63537calcium-ionregulatedexocytosisneurotransmittersecretionregulationofneurotransmittersecretionsynapticvesicleclusteringsynapticvesiclecycle
AT-rich interactive domain-containing protein 2
9.5
62
39
ARID2ARID2Q68CP9Q68CP9cardiacmusclecellproliferationchromatinremodelingcoronaryarterymorphogenesisembryonicorgandevelopmentheartmorphogenesishomeostaticprocessnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnucleosomedisassemblypositiveregulationofcelldifferentiationpositiveregulationofdouble-strandbreakrepairpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationofmyoblastdifferentiationpositiveregulationofTcelldifferentiationregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseII
Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14
9.5
76
29
Q4V8E2Q4V8E2Q4V8E2Q4V8E2double-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairvianonhomologousendjoiningproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeubiquitinationproteinK63-linkeddeubiquitinationregulationofproteasomalproteincatabolicprocessresponsetoethanol
Calcium/calmodulin-dependent protein kinase type II subunit beta
9.8
75
27
KCC2BKCC2BQ13554Q13554celldifferentiationnervoussystemdevelopmentpeptidyl-serinephosphorylationpositiveregulationofdendriticspinemorphogenesispositiveregulationofneuronprojectiondevelopmentpositiveregulationofsynapsematurationproteinautophosphorylationproteinphosphorylationregulationofcalciumiontransportregulationofdendriticspinedevelopmentregulationoflong-termneuronalsynapticplasticityregulationofneuronmigrationregulationofskeletalmuscleadaptationregulationofsynapsestructuralplasticitysignaltransduction
Protein kinase C and casein kinase substrate in neurons protein 2
9.5
54
44
✔
PACN2PACN2Q9UNF0Q9UNF0actincytoskeletonorganizationcaveolaassemblycaveolin-mediatedendocytosiscellprojectionmorphogenesiscytoskeletonorganizationmodulationofchemicalsynaptictransmissionnegativeregulationofendocytosisplasmamembranetubulationproteinlocalizationtoendosomeregulationofendocytosis
Hypoxia-inducible factor 3-alpha
3.6
79
70
HIF3AHIF3AQ0VBL6Q0VBL6angiogenesisapoptoticprocesscellularresponsetohypoxiapositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetohypoxiatranscriptionbyRNApolymeraseII
KIF-binding protein
9.2
65
44
KBPKBPQ96EK5Q96EK5centralnervoussystemprojectionneuronaxonogenesisinuteroembryonicdevelopmentmicrotubulecytoskeletonorganizationmitochondrialtransportneuronprojectionmaintenance
F-box only protein 44
9.5
73
34
FBX44FBX44Q9H4M3Q9H4M3glycoproteincatabolicprocessproteasomalproteincatabolicprocessproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessubiquitin-dependentERADpathway
Interleukin-37
9.8
47
45
IL37IL37Q9NZH6Q9NZH6cellularresponsetolipopolysaccharidecytokine-mediatedsignalingpathwayimmuneresponseinflammatoryresponseinflammatoryresponsetoantigenicstimulusnegativeregulationofinterleukin-6productionnegativeregulationoftumornecrosisfactorproductionpositiveregulationofgeneexpressionregulationofinflammatoryresponse
Protein kinase C iota type
9.5
73
32
✔
KPCIKPCIQ62074Q62074actinfilamentorganizationcellmigrationcell-celljunctionorganizationcellularresponsetoinsulinstimulusestablishmentofapical/basalcellpolarityestablishmentormaintenanceofepithelialcellapical/basalpolarityeyephotoreceptorcelldevelopmentGolgivesiclebuddingintracellularsignaltransductionnegativeregulationofglialcellapoptoticprocessnegativeregulationofneuronapoptoticprocesspeptidyl-serinephosphorylationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofglialcellproliferationpositiveregulationofglucoseimportpositiveregulationofneuronprojectiondevelopmentpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinlocalizationtoplasmamembraneproteinlocalizationproteinphosphorylationregulationofpostsynapticmembraneneurotransmitterreceptorlevelsresponsetointerleukin-1responsetopeptidehormone
Neuronal PAS domain-containing protein 1
9.5
65
37
NPAS1NPAS1P97459P97459maternalbehaviornegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIstartleresponse
ICT1
9.5
55
41
W5IDC0W5IDC0W5IDC0W5IDC0
Acyl-coenzyme A synthetase ACSM2A, mitochondrial
9.5
82
38
ACS2AACS2AQ08AH3Q08AH3acyl-CoAmetabolicprocessfattyacidbiosyntheticprocessglucosehomeostasismedium-chainfatty-acyl-CoAmetabolicprocesstriglyceridehomeostasis
Rab GTPase-activating protein 1
9.5
66
36
RBGP1RBGP1Q9Y3P9Q9Y3P9activationofGTPaseactivitycellcycleregulationofGTPaseactivity
Nuclear inhibitor of protein phosphatase 1
9.5
56
46
PP1R8PP1R8Q8R3G1Q8R3G1cellpopulationproliferationmRNAprocessingnegativeregulationofproteindephosphorylationRNAsplicing
40S ribosomal protein S3a
9.5
70
35
G1TN72G1TN72G1TN72G1TN72celldifferentiationtranslation
Quinone oxidoreductase-like protein 1
9.5
78
34
QORL1QORL1O95825O95825quinonemetabolicprocess
Cullin-4B
9.5
67
30
CUL4BCUL4BQ13620Q13620astrocytedifferentiationcellularresponsetoDNAdamagestimuluscellularresponsetoUVG1/StransitionofmitoticcellcyclegeneexpressionhistoneH2AmonoubiquitinationneuronprojectiondevelopmentpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofproteincatabolicprocessproteasomalproteincatabolicprocessproteinubiquitinationribosomebiogenesisSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessUV-damageexcisionrepair
Peptidyl-prolyl cis-trans isomerase
9.5
83
30
V9HWF5V9HWF5V9HWF5V9HWF5proteinfoldingproteinpeptidyl-prolylisomerization
Cyclin-dependent kinase 4
4.7
41
73
✔
CCND1CDK4P24385P11802celldivisioncellularresponsetoDNAdamagestimulusendoplasmicreticulumunfoldedproteinresponsefatcelldifferentiationG1/StransitionofmitoticcellcyclelactationLeydigcelldifferentiationliverregenerationmammaryglandalveolusdevelopmentmammaryglandepithelialcellproliferationmitoticcellcyclephasetransitionmitoticG1DNAdamagecheckpointsignalingnegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIneurondifferentiationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofG2/Mtransitionofmitoticcellcyclepositiveregulationofmammaryglandepithelialcellproliferationpositiveregulationofproteinphosphorylationproteinphosphorylationre-entryintomitoticcellcycleregulationofcyclin-dependentproteinserine/threoninekinaseactivityresponsetocalciumionresponsetocorticosteroneresponsetoestradiolresponsetoestrogenresponsetoethanolresponsetoironionresponsetoleptinresponsetomagnesiumionresponsetoorganonitrogencompoundresponsetoUV-AresponsetovitaminEresponsetoX-rayresponsetoxenobioticstimulusWntsignalingpathwayadiposetissuedevelopmentcellularresponsetoinsulinstimuluscellularresponsetointerleukin-4cellularresponsetoionomycincellularresponsetolipopolysaccharidecellularresponsetophorbol13-acetate12-myristatepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationregulationofcellcycleregulationofgeneexpressionregulationofinsulinreceptorsignalingpathwayregulationoflipidbiosyntheticprocessregulationoflipidcatabolicprocessregulationofmulticellularorganismgrowthregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftypeBpancreaticcellproliferationsignaltransduction
Amyloid beta precursor protein binding family B member 2
8.4
71
39
APBB2APBB2Q9DBR4Q9DBR4axonguidanceextracellularmatrixorganizationmaintenanceoflenstransparencynegativeregulationofapoptoticprocessnegativeregulationofcellcyclephasetransitionnegativeregulationoftranscriptionbyRNApolymeraseIIneuronmigrationpositiveregulationofapoptoticprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationregulationofDNA-templatedtranscriptionsmoothmusclecontraction
Bardet-Biedl syndrome 1
9.6
74
35
E1BN34E1BN34E1BN34E1BN34adultbehaviorbrainmorphogenesiscartilagedevelopmentcellularlipidmetabolicprocesscerebralcortexdevelopmentdendritedevelopmentfatcelldifferentiationfertilizationGolgitoplasmamembraneproteintransporthippocampusdevelopmenthormonemetabolicprocessmicrotubulecytoskeletonorganizationneuralprecursorcellproliferationneuronmigrationnon-motileciliumassemblyolfactorybehaviorphotoreceptorcellmaintenancephotoreceptorcellmorphogenesisproteinlocalizationtociliumregulationofciliumbeatfrequencyinvolvedinciliarymotilitysensoryperceptionofsmellstriatumdevelopmentventricularsystemdevelopment
Peptidyl-prolyl cis-trans isomerase
9.6
84
30
B1P761B1P761B1P761B1P761proteinfoldingproteinpeptidyl-prolylisomerization
Zinc finger protein AEBP2
9.6
53
49
AEBP2AEBP2Q6ZN18Q6ZN18chromatinorganizationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Ribonuclease P protein subunit p30
9.6
63
40
RPP30RPP30P78346P78346RNAphosphodiesterbondhydrolysisendonucleolyticrRNAprocessing"tRNA5-leaderremoval"tRNAprocessing
Kinesin family member 13B
9.6
62
36
A0A0G2K8Z9A0A0G2K8Z9A0A0G2K8Z9A0A0G2K8Z9microtubule-basedmovementregulationofaxonogenesis
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
3.8
79
66
NMNA3NMNA3Q96T66Q96T66NADbiosyntheticprocessnucleotidebiosyntheticprocess
Bestrophin-1
9.6
65
31
BEST1BEST1O76090O76090chloridetransportdetectionoflightstimulusinvolvedinvisualperceptioniontransmembranetransportregulationofcalciumiontransporttransepithelialchloridetransportvisualperception
F-box only protein 2
9.6
68
33
✔
FBX2FBX2Q80UW2Q80UW2glycoproteincatabolicprocessnegativeregulationofcellpopulationproliferationproteinubiquitinationregulationofproteincatabolicprocessatpostsynapsemodulatingsynaptictransmissionregulationofproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocess
Cytochrome b5 reductase 4
9.6
80
24
NB5R4NB5R4Q7L1T6Q7L1T6bicarbonatetransportcelldevelopmentdetectionofoxygengenerationofprecursormetabolitesandenergyglucosehomeostasisinsulinsecretionreactiveoxygenspeciesmetabolicprocessresponsetoantibioticsuperoxidemetabolicprocess
Transient receptor potential cation channel subfamily V member 2
2.0
nan
94
G1SNM3G1SNM3G1SNM3G1SNM3positiveregulationofaxonextensionpositiveregulationofcalciumionimportpositiveregulationofcold-inducedthermogenesisresponsetotemperaturestimulus
Mediator of RNA polymerase II transcription subunit 29
9.6
40
43
✔
MED29MED29Q9NX70Q9NX70positiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassembly
Cofilin-1
9.6
75
35
✔
COF1COF1P23528P23528actincytoskeletonorganizationactinfilamentdepolymerizationactinfilamentfragmentationactinfilamentseveringcytoskeletonorganizationestablishmentofspindlelocalizationmitoticcytokinesisnegativeregulationofapoptoticprocesspositiveregulationbyhostofviralprocesspositiveregulationofembryonicdevelopmentregulationofcellmorphogenesisregulationofdendriticspinemorphogenesisresponsetovirusRhoproteinsignaltransduction
Interferon-induced protein with tetratricopeptide repeats 5
9.6
54
39
✔
IFIT5IFIT5Q13325Q13325defenseresponsetovirusinnateimmuneresponsenegativeregulationofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignaling
Signal-transducing adaptor protein 2
9.6
48
43
STAP2STAP2Q9UGK3Q9UGK3
Ragulator complex protein LAMTOR4
9.6
98
27
✔
LTOR4LTOR4Q0VGL1Q0VGL1cellularresponsetoaminoacidstimuluspositiveregulationofTORsignalingproteinlocalizationtolysosomeregulationofcellsizeTORC1signaling
Rho GTPase-activating protein 25
9.6
54
43
RHG25RHG25P42331P42331actinfilamentorganizationactivationofGTPaseactivitynegativeregulationofsmallGTPasemediatedsignaltransductionphagocytosisengulfmentsignaltransduction
Hypoxia-inducible factor 1-alpha
2.0
78
81
✔
EGLN1HIF1AQ9GZT9Q16665cardiacmuscletissuemorphogenesiscellularironionhomeostasiscellularoxygenhomeostasiscellularresponsetohypoxiahearttrabeculaformationlabyrinthinelayerdevelopmentnegativeregulationofcyclic-nucleotidephosphodiesteraseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivitypeptidyl-prolinehydroxylationto4-hydroxy-L-prolinepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofmodificationofpostsynapticstructureregulationofneurondeathregulationproteincatabolicprocessatpostsynapseresponsetohypoxiaresponsetonitricoxideventricularseptummorphogenesisangiogenesisaxonaltransportofmitochondrionB-1Bcellhomeostasisbonemineralizationcardiacventriclemorphogenesiscellularglucosehomeostasiscellularresponsetointerleukin-1cellularresponsetoviruscerebralcortexdevelopmentchondrocytedifferentiationcollagenmetabolicprocessconnectivetissuereplacementinvolvedininflammatoryresponsewoundhealingdigestivetractmorphogenesisdopaminergicneurondifferentiationelastinmetabolicprocessembryonichemopoiesisembryonicplacentadevelopmentepithelialcelldifferentiationinvolvedinmammaryglandalveolusdevelopmentepithelialtomesenchymaltransitionglandularepithelialcellmaturationheartloopinghemoglobinbiosyntheticprocesshypoxia-induciblefactor-1alphasignalingpathwayinsulinsecretioninvolvedincellularresponsetoglucosestimulusintestinalepithelialcellmaturationirismorphogenesislactatemetabolicprocesslactationmesenchymalcellapoptoticprocessmusclecellcellularhomeostasisnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofgrowthnegativeregulationofmesenchymalcellapoptoticprocessnegativeregulationofoxidativestress-inducedneuronintrinsicapoptoticsignalingpathwaynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationofthymocyteapoptoticprocessnegativeregulationofTORsignalingneuralcrestcellmigrationneuralfoldelevationformationneuroblastproliferationneuronapoptoticprocessoutflowtractmorphogenesispositiveregulationofangiogenesispositiveregulationofautophagyofmitochondrionpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofchemokineproductionpositiveregulationofchemokine-mediatedsignalingpathwaypositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellproliferationpositiveregulationofepithelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofhormonebiosyntheticprocesspositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationofmacroautophagypositiveregulationofmiRNAtranscriptionpositiveregulationofneuroblastproliferationpositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofsignalingreceptoractivitypositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationofvascularendothelialgrowthfactorproductionpositiveregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayregulationofaerobicrespirationregulationofDNA-templatedtranscriptionregulationofgeneexpressionregulationofglycolyticprocessregulationofproteinneddylationregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetooxidativestressregulationoftransforminggrowthfactorbeta2productionresponsetoironionresponsetomuscleactivityresponsetoreactiveoxygenspeciesretinavasculaturedevelopmentincamera-typeeyesignaltransductionTORsignalingvascularendothelialgrowthfactorproductionvisuallearning
Protein SSXT
9.6
57
41
SSXTSSXTQ15532Q15532cellmorphogenesischromatinremodelingephrinreceptorsignalingpathwayintracellularsignaltransductionmicrotubulecytoskeletonorganizationnegativeregulationofcelldifferentiationneuronalstemcellpopulationmaintenancepositiveregulationofcellpopulationproliferationpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulus
Cytochrome P450 2D6
9.7
44
42
CP2D6CP2D6P10635P10635alkaloidcatabolicprocessalkaloidmetabolicprocessarachidonicacidmetabolicprocesscholesterolmetabolicprocesscoumarinmetabolicprocessestrogenmetabolicprocessheterocyclemetabolicprocessisoquinolinealkaloidmetabolicprocesslong-chainfattyacidbiosyntheticprocessmonoterpenoidmetabolicprocessnegativeregulationofbindingnegativeregulationofcellularorganofluorinemetabolicprocessorganicacidmetabolicprocessoxidativedemethylationretinolmetabolicprocesssteroidmetabolicprocessxenobioticcatabolicprocessxenobioticmetabolicprocess
Ubiquitin carboxyl-terminal hydrolase 14
9.6
83
29
✔
UBP14UBP14P54578P54578chemicalsynaptictransmissioninnateimmuneresponsenegativeregulationofER-associatedubiquitin-dependentproteincatabolicprocesspositiveregulationofNF-kappaBtranscriptionfactoractivityproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteindeubiquitinationregulationofchemotaxisregulationofproteasomalproteincatabolicprocess
Malignant T-cell-amplified sequence 1
9.6
58
42
✔
MCTS1MCTS1Q9ULC4Q9ULC4cellcyclecellularresponsetoDNAdamagestimulusformationoftranslationpreinitiationcomplexIRES-dependentviraltranslationalinitiationpositiveregulationofcellpopulationproliferationribosomedisassembly
Type II inositol 1,4,5-trisphosphate 5-phosphatase
9.6
72
30
I5P2I5P2P32019P32019flagellatedspermmotilityinuteroembryonicdevelopmentinositolphosphatedephosphorylationinositolphosphatemetabolicprocessphosphatidylinositoldephosphorylationregulationofproteinprocessingsignaltransductionspermatogenesis
Mitogen-activated protein kinase 8
9.6
72
30
MK08MK08P45983P45983cellularresponsetoaminoacidstarvationcellularresponsetocadmiumioncellularresponsetolipopolysaccharidecellularresponsetomechanicalstimuluscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspeciescellularsenescenceFc-epsilonreceptorsignalingpathwayintracellularsignaltransductionJNKcascadeJUNphosphorylationnegativeregulationofapoptoticprocessnegativeregulationofproteinbindingpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofapoptoticprocesspositiveregulationofcellkillingpositiveregulationofcyclaseactivitypositiveregulationofdeacetylaseactivitypositiveregulationofgeneexpressionpositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwaypositiveregulationofproteinmetabolicprocessproteinphosphorylationregulationofcircadianrhythmregulationofDNAreplicationoriginbindingregulationofDNA-bindingtranscriptionfactoractivityregulationofmacroautophagyregulationofproteinlocalizationresponsetomechanicalstimulusresponsetooxidativestressresponsetoUVrhythmicprocessstress-activatedMAPKcascade
Tripartite motif-containing protein 5
2.0
69
80
B0LJC8B0LJC8B0LJC8B0LJC8autophagydefenseresponsetovirusinnateimmuneresponseproteinfoldingproteinpeptidyl-prolylisomerizationproteinubiquitination
X-ray repair cross-complementing protein 6
9.6
76
29
XRCC6XRCC6P12956P12956activationofinnateimmuneresponsecellularresponsetogammaradiationcellularresponsetoX-rayDNAligationdouble-strandbreakrepairviaclassicalnonhomologousendjoiningdouble-strandbreakrepairvianonhomologousendjoininginnateimmuneresponsenegativeregulationofDNA-templatedtranscriptionpositiveregulationofDNA-templatedtranscriptionpositiveregulationoflymphocytedifferentiationpositiveregulationofproteinkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIrecombinationalrepairregulationofsmoothmusclecellproliferationtelomeremaintenance
DNA-directed RNA polymerase II subunit RPB4
9.6
70
33
A0A481BYI6A0A481BYI6A0A481BYI6A0A481BYI6DNA-templatedtranscriptioninitiationtranscriptionbyRNApolymeraseII
Cytosol aminopeptidase
9.6
102
27
AMPLAMPLP00727P00727proteolysis
Mitochondrial transcription termination factor 1
9.6
61
36
B4DPR9B4DPR9B4DPR9B4DPR9regulationofDNA-templatedtranscription
Dual specificity protein phosphatase 8
9.6
41
45
DUS8DUS8Q13202Q13202dephosphorylationnegativeregulationofMAPKcascadeproteindephosphorylation
Vacuolar protein sorting-associated protein 29
9.7
58
39
✔
VPS29VPS29Q9UBQ0Q9UBQ0endocyticrecyclingintracellularproteintransportretrogradetransportendosometoGolgi
Methionine adenosyltransferase 2 subunit beta
6.6
85
44
MAT2BMAT2BQ9NZL9Q9NZL9one-carbonmetabolicprocessS-adenosylmethioninebiosyntheticprocess
Cytosolic beta-glucosidase
9.6
82
27
GBA3GBA3Q9H227Q9H227beta-glucosidecatabolicprocesscellularoligosaccharidecatabolicprocessgalactosylceramidecatabolicprocessglucosylceramidecatabolicprocessglycosidecatabolicprocessglycosphingolipidmetabolicprocessglycosylceramidecatabolicprocesspositiveregulationofexo-alpha-sialidaseactivityproteinstabilization
Mortality factor 4-like protein 1
9.6
74
36
MO4L1MO4L1Q9UBU8Q9UBU8chromatinorganizationdouble-strandbreakrepairviahomologousrecombinationfibroblastproliferationhistoneacetylationhistonedeacetylationhistoneH2AacetylationhistoneH4acetylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofapoptoticprocessregulationofcellcycleregulationofdouble-strandbreakrepair
Elongator complex protein 3
6.4
68
55
ELP3ELP3Q9CZX0Q9CZX0centralnervoussystemdevelopmentneuronmigrationpositiveregulationofcellmigrationregulationoftranscriptionbyRNApolymeraseIItRNAwobblebase5-methoxycarbonylmethyl-2-thiouridinylationtRNAwobbleuridinemodification
CCR4-NOT transcription complex subunit 9
9.6
80
26
CNOT9CNOT9Q92600Q92600cytokine-mediatedsignalingpathwaynegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationoftranslationnuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofpeptidyl-serinephosphorylationRNA-mediatedgenesilencingsexdifferentiation
Checkpoint protein HUS1
9.7
65
36
HUS1HUS1O60921O60921cellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationDNAdamagecheckpointsignalingDNArepairdouble-strandbreakrepairviahomologousrecombinationembryodevelopmentendinginbirthoregghatchingmeioticDNAintegritycheckpointsignalingmitoticDNAreplicationcheckpointsignalingmitoticintra-SDNAdamagecheckpointsignalingnucleotide-excisionrepairproteinphosphorylationregulationofproteinphosphorylationresponsetoUVtelomeremaintenance
Excitatory amino acid transporter 1
9.7
72
30
EAA1EAA1P43003P43003auditorybehaviorcellmorphogenesisinvolvedinneurondifferentiationcellularresponsetococainecellularsodiumionhomeostasischemicalsynaptictransmissionchloridetransmembranetransportcranialnervedevelopmentD-aspartateimportacrossplasmamembranegamma-aminobutyricacidbiosyntheticprocessiontransportL-aspartateimportacrossplasmamembraneL-glutamateimportL-glutamateimportacrossplasmamembraneL-glutamatetransmembranetransportneuromuscularprocesscontrollingbalanceneurotransmittertransportneurotransmitteruptakepositiveregulationofsynaptictransmissionpotassiumiontransmembranetransportresponsetoantibioticresponsetolightstimulusresponsetowoundingresponsetoxenobioticstimulussensoryperceptionofsoundtransepithelialtransporttransportacrossblood-brainbarrier
Bardet-Biedl syndrome 7 protein homolog
9.7
42
42
F1MB52F1MB52F1MB52F1MB52ciliumassemblyintracellulartransportnon-motileciliumassemblypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinlocalizationproteintransportregulationoftranscriptionbyRNApolymeraseII
Ragulator complex protein LAMTOR2
9.7
73
36
LTOR2LTOR2Q9JHS3Q9JHS3cellularresponsetoaminoacidstimulusfibroblastmigrationpositiveregulationofMAPKcascadepositiveregulationofTORsignalingproteinlocalizationproteinlocalizationtocelljunctionregulationofcellgrowthregulationofcell-substratejunctionorganizationTORC1signaling
Ferritin
9.7
63
41
Q9CPX4Q9CPX4Q9CPX4Q9CPX4cellularironionhomeostasisironiontransport
Paternally-expressed gene 3 protein
9.7
67
33
PEG3PEG3Q9GZU2Q9GZU2apoptoticprocessnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionregulationoftranscriptionbyRNApolymeraseII
Engulfment and cell motility protein 1
9.1
nan
47
DOCK2ELMO1Q92608Q92556actincytoskeletonorganizationalpha-betaTcellproliferationcellmigrationchemotaxisestablishmentofTcellpolarityimmunologicalsynapseformationmacropinocytosismembraneraftpolarizationmyeloiddendriticcellactivationinvolvedinimmuneresponsemyoblastfusionnegativethymicTcellselectionpositiveregulationofphagocytosispositivethymicTcellselectionregulationofsmallGTPasemediatedsignaltransductionsmallGTPasemediatedsignaltransductionactinfilamentorganizationapoptoticprocesscellmotilityphagocytosisengulfmentRacproteinsignaltransduction
Mitochondrial antiviral-signaling protein
2.0
72
84
TRAF3MAVSQ60803Q8VCF0apoptoticprocessinnateimmuneresponsenegativeregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofJNKcascadeproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofcytokineproductionregulationofdefenseresponsetovirusregulationofI-kappaBkinase/NF-kappaBsignalingregulationofinterferon-betaproductionregulationofproteolysisTollsignalingpathwaytoll-likereceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwayactivationofinnateimmuneresponsecellularresponsetoexogenousdsRNAcellularresponsetointerferon-betadefenseresponsetobacteriumdefenseresponsetovirusnegativeregulationofviralgenomereplicationpositiveregulationofchemokine(C-Cmotif)ligand5productionpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofIP-10productionpositiveregulationofmyeloiddendriticcellcytokineproductionpositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofproteinhomodimerizationactivitypositiveregulationofproteinimportintonucleuspositiveregulationofproteinphosphorylationpositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferonproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwayproteinlocalizationtomitochondrionproteintetramerizationregulationofperoxisomeorganizationRIG-Isignalingpathwaysignaltransduction
Enoyl-CoA hydratase, mitochondrial
9.7
65
33
ECHMECHMP30084P30084branched-chainaminoacidcatabolicprocessfattyacidbeta-oxidation
RAR-related orphan receptor C
9.7
46
39
Q6I9R9Q6I9R9Q6I9R9Q6I9R9
COP9 signalosome complex subunit 5
9.7
79
28
✔
CSN5CSN6Q92905Q7L5N1exosomalsecretionnegativeregulationofapoptoticprocesspositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationoftranscriptionbyRNApolymeraseIIpost-translationalproteinmodificationproteindeneddylationproteindeubiquitinationproteinneddylationregulationofcellcycleregulationofIRE1-mediatedunfoldedproteinresponseregulationofJNKcascaderegulationofproteinneddylationtranslation
Adenomatous polyposis coli protein
6.5
56
59
APCAPCP25054P25054bicellulartightjunctionassemblycelladhesioncellfatespecificationcellmigrationcellularresponsetoDNAdamagestimulusendocardialcushionmorphogenesisheartvalvedevelopmentinsulinreceptorsignalingpathwaymitoticcytokinesismitoticspindleassemblycheckpointsignalingnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellcycleG1/Sphasetransitionnegativeregulationofcellpopulationproliferationnegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofmicrotubuledepolymerizationnervoussystemdevelopmentpatternspecificationprocesspositiveregulationofapoptoticprocesspositiveregulationofcelldeathpositiveregulationofcellmigrationpositiveregulationofcold-inducedthermogenesispositiveregulationofproteincatabolicprocesspositiveregulationofproteinlocalizationtocentrosomepositiveregulationofpseudopodiumassemblyproteasome-mediatedubiquitin-dependentproteincatabolicprocessprotein-containingcomplexassemblyregulationofattachmentofspindlemicrotubulestokinetochoreregulationofcelldifferentiationregulationofmicrotubule-basedprocessWntsignalingpathway
Endoribonuclease Dicer
9.6
54
41
DICERDICERQ9UPY3Q9UPY3apoptoticDNAfragmentationglobalgenesilencingbymRNAcleavagemiRNAmetabolicprocessmiRNAprocessingnegativeregulationofgeneexpressionnegativeregulationofSchwanncellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftumornecrosisfactorproductionnervedevelopmentneuronprojectionmorphogenesisNIK/NF-kappaBsignalingperipheralnervoussystemmyelinformationpositiveregulationofmyelinationpositiveregulationofSchwanncelldifferentiationpre-miRNAprocessingRISCcomplexassemblyRNAphosphodiesterbondhydrolysisRNAphosphodiesterbondhydrolysisendonucleolyticsiRNAprocessingtRNAcatabolicprocess
Sulfotransferase 1C2
9.7
80
26
ST1C2ST1C2O00338O00338aminemetabolicprocesssulfation
MAP kinase-activated protein kinase 2
9.7
45
43
MAPK2MAPK2P49137P49137"3-UTR-mediatedmRNAstabilization"cellularresponsetoDNAdamagestimuluscellularresponsetovascularendothelialgrowthfactorstimulusinflammatoryresponseinnereardevelopmentintracellularsignaltransductionleukotrienemetabolicprocessmacropinocytosisMAPKcascadep38MAPKcascadepeptidyl-serinephosphorylationpositiveregulationofmacrophagecytokineproductionpositiveregulationoftumornecrosisfactorproductionproteinautophosphorylationproteinphosphorylationregulationofcellularresponsetoheatregulationofinterleukin-6productionregulationofmRNAstabilityregulationoftumornecrosisfactorproductionresponsetocytokineresponsetolipopolysaccharidetoll-likereceptorsignalingpathwayvascularendothelialgrowthfactorreceptorsignalingpathway
Sodium/hydrogen exchanger 9B2
9.7
67
32
SL9B2SL9B2Q86UD5Q86UD5clathrin-dependentendocytosisflagellatedspermmotilityiontransmembranetransportpositiveregulationofosteoclastdevelopmentregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulussodiumiontransport
Prefoldin subunit 2
9.7
66
33
PFD2PFD3Q9UHV9P61758negativeregulationofamyloidfibrilformationpositiveregulationofcytoskeletonorganizationproteinfoldingproteinstabilizationmicrotubule-basedprocesstubulincomplexassembly
GTP-binding nuclear protein Ran
9.7
69
35
✔
RANRANP62825P62825celldivisionGTPmetabolicprocessmitoticsisterchromatidsegregationpositiveregulationofproteinexportfromnucleuspre-miRNAexportfromnucleusproteinexportfromnucleusproteinimportintonucleusribosomalsubunitexportfromnucleussnRNAimportintonucleus
Sorting nexin-16
9.7
63
36
SNX16SNX16P57768P57768earlyendosometolateendosometransportendosometolysosometransportproteintargetingtolysosome
Cell cycle checkpoint control protein RAD9A
7.6
45
50
RAD9ARAD9AQ99638Q99638cellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationDNAdamagecheckpointsignalingDNArepairDNAreplicationcheckpointsignalingintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagemitoticintra-SDNAdamagecheckpointsignalingpositiveregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamage
La-related protein 4
9.7
52
44
LARP4LARP4Q71RC2Q71RC2cytoskeletonorganizationpositiveregulationoftranslationpost-transcriptionalregulationofgeneexpressionregulationofcellmorphogenesistranslation
TMEM106B protein
4.9
52
69
Q8N353Q8N353Q8N353Q8N353
Transmembrane protein 106B
4.9
53
71
T106BT106BQ9NUM4Q9NUM4dendritemorphogenesislysosomallumenacidificationlysosomalproteincatabolicprocesslysosomaltransportlysosomelocalizationlysosomeorganizationneuroncellularhomeostasispositiveregulationofdendritedevelopmentpositiveregulationofhydrolaseactivityregulationoflysosomeorganization
Myotrophin
2.0
58
84
MTPNMTPNP58546P58546catecholaminemetabolicprocesscellularresponsetomechanicalstimuluscerebellargranulecelldifferentiationneurondifferentiationpositiveregulationofcardiacmusclehypertrophypositiveregulationofcellgrowthpositiveregulationofmacromoleculebiosyntheticprocesspositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteinmetabolicprocessregulationofbarbed-endactinfilamentcappingregulationofcellsizeregulationofstriatedmuscletissuedevelopmentregulationoftranslationskeletalmuscletissueregenerationstriatedmusclecelldifferentiation
Serine/threonine-protein kinase STK11
9.7
54
37
STK11STK11Q15831Q15831activationofproteinkinaseactivityanoikisautophagyaxonogenesiscellularresponsetoDNAdamagestimuluscellularresponsetoUV-BdendriteextensionepithelialcellproliferationinvolvedinprostateglanddevelopmentestablishmentofcellpolarityG1toG0transitionglucosehomeostasisGolgilocalizationintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcold-inducedthermogenesisnegativeregulationofepithelialcellproliferationinvolvedinprostateglanddevelopmentnegativeregulationofTORC1signalingpeptidyl-threoninephosphorylationpositiveregulationofautophagypositiveregulationofaxonogenesispositiveregulationofgluconeogenesispositiveregulationofproteinlocalizationtonucleuspositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofvesicletransportalongmicrotubulepositivethymicTcellselectionproteinautophosphorylationproteindephosphorylationproteinlocalizationtonucleusproteinphosphorylationregulationofcellcycleregulationofcellgrowthregulationofdendritemorphogenesisregulationofproteinkinaseBsignalingregulationofsignaltransductionbyp53classmediatorregulationofWntsignalingpathwayresponsetoactivityresponsetoglucagonresponsetoionizingradiationresponsetolipidresponsetothyroidhormonesignaltransductionspermatogenesisTcellreceptorsignalingpathwaytissuehomeostasisvasculaturedevelopment
tRNA methyltransferase 10 homolog A
9.7
73
39
TM10ATM10AQ8TBZ6Q8TBZ6tRNAmethylationtRNAN1-guaninemethylation
U5 small nuclear ribonucleoprotein 200 kDa helicase
2.0
59
82
✔
U520U520O75643O75643cisassemblyofpre-catalyticspliceosomemRNAsplicingviaspliceosomeosteoblastdifferentiationspliceosomeconformationalchangetoreleaseU4(orU4atac)andU1(orU11)
Tripartite motif-containing protein 5
9.7
87
28
B0ZE32B0ZE32B0ZE32B0ZE32autophagydefenseresponsetovirusinnateimmuneresponseproteinpeptidyl-prolylisomerizationproteinubiquitination
Vesicle-trafficking protein SEC22b
9.7
77
32
SC22BSC22BO08547O08547endoplasmicreticulumtoGolgivesicle-mediatedtransportnegativeregulationofautophagosomeassemblypositiveregulationofproteincatabolicprocessproteintransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumvesiclefusionwithGolgiapparatusvesicle-mediatedtransport
TOG array regulator of axonemal microtubules protein 1
9.7
84
26
TGRM1TGRM1Q6A070Q6A070axonemeassemblyciliumassemblymicrotubulecytoskeletonorganizationmitoticspindleassemblynon-motileciliumassemblypositiveregulationofmicrotubulepolymerization
16L protein
9.7
67
36
✔
Q9DHU6BAXQ9DHU6Q07812suppressionbyvirusofhostapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayapoptoticmitochondrialchangesapoptoticprocessapoptoticprocessinvolvedinbloodvesselmorphogenesisapoptoticprocessinvolvedinembryonicdigitmorphogenesisapoptoticprocessinvolvedinmammaryglandinvolutionapoptoticsignalingpathwayBcellapoptoticprocessBcellhomeostasisBcellhomeostaticproliferationBcellnegativeselectionBcellreceptorapoptoticsignalingpathwaybloodvesselremodelingcalciumiontransportintocytosolcellularresponsetounfoldedproteincellularresponsetoUVcellularresponsetoviruscerebralcortexdevelopmentdevelopmentofsecondarysexualcharacteristicsectopicgermcellprogrammedcelldeathendoplasmicreticulumcalciumionhomeostasisepithelialcellapoptoticprocessestablishmentormaintenanceoftransmembraneelectrochemicalgradientextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsfertilizationgermcelldevelopmentglycosphingolipidmetabolicprocesshomeostasisofnumberofcellswithinatissuehypothalamusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresskidneydevelopmentmitochondrialfragmentationinvolvedinapoptoticprocessmitochondrialfusionmitochondrionmorphogenesismotorneuronapoptoticprocessmyeloidcellhomeostasisnegativeregulationofapoptoticsignalingpathwaynegativeregulationofendoplasmicreticulumcalciumionconcentrationnegativeregulationoffibroblastproliferationnegativeregulationofmitochondrialmembranepotentialnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofproteinbindingneuronmigrationodontogenesisofdentin-containingtoothovarianfollicledevelopmentpeptidyl-serinephosphorylationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofBcellapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofdevelopmentalpigmentationpositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationofepithelialcellapoptoticprocesspositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofIRE1-mediatedunfoldedproteinresponsepositiveregulationofmotorneuronapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofprotein-containingcomplexassemblypositiveregulationofreleaseofcytochromecfrommitochondriapositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofreproductiveprocesspost-embryoniccamera-typeeyemorphogenesisproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwayregulationofapoptoticprocessregulationofcellcycleregulationofmammaryglandepithelialcellproliferationregulationofmitochondrialmembranepermeabilityinvolvedinprogrammednecroticcelldeathregulationofmitochondrialmembranepotentialregulationofnitrogenutilizationreleaseofcytochromecfrommitochondriareleaseofmatrixenzymesfrommitochondriareleaseofsequesteredcalciumionintocytosolresponsetoaxoninjuryresponsetogammaradiationresponsetosaltstressresponsetotoxicsubstanceretinadevelopmentincamera-typeeyeretinalcellprogrammedcelldeathSertolicellproliferationspermatiddifferentiationsupramolecularfiberorganizationTcellhomeostaticproliferationthymocyteapoptoticprocessvaginadevelopment
Menin
9.8
70
30
MEN1MEN1O00255O00255braindevelopmentcellularresponsetoDNAdamagestimuluscellularresponsetoglucosestimuluscellularresponsetopeptidehormonestimuluschromatinorganizationdecidualizationDNArepairhistoneH3-K4methylationMAPKcascademitoticcellcyclenegativeregulationofcellcyclenegativeregulationofcellcycleG1/Sphasetransitionnegativeregulationofcellpopulationproliferationnegativeregulationofcell-substrateadhesionnegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationnegativeregulationofJNKcascadenegativeregulationofosteoblastdifferentiationnegativeregulationofproteinphosphorylationnegativeregulationoftelomeraseactivitynegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastdevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwayregulationofactivinreceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationoftypeBpancreaticcellproliferationresponsetogammaradiationresponsetotransforminggrowthfactorbetaresponsetoUVT-helper2celldifferentiationtypeBpancreaticcelldifferentiation
GDP-L-fucose synthase
9.8
93
29
✔
FCLFCLQ13630Q13630"denovoGDP-L-fucosebiosyntheticprocess"GDP-mannosemetabolicprocessleukocytecell-celladhesionpositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcell-matrixadhesionviafibronectin
Serine/threonine-protein kinase Nek2
9.8
61
36
NEK2NEK2P51955P51955blastocystdevelopmentcelldivisioncentrosomeseparationchromosomesegregationmeioticcellcyclemitoticcellcyclemitoticsisterchromatidsegregationmitoticspindleassemblynegativeregulationofcentriole-centriolecohesionnegativeregulationofDNAbindingpositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomeraseproteinautophosphorylationproteinphosphorylationregulationofattachmentofspindlemicrotubulestokinetochoreregulationofmitoticcentrosomeseparationregulationofmitoticnucleardivisionspindleassembly
Galectin-8
9.8
68
34
LEG8LEG8O00214O00214cellularresponsetoviruslymphaticendothelialcellmigrationxenophagy
RNA-binding protein 20
9.8
63
36
RBM20RBM20Q3UQS8Q3UQS8heartformationmRNAprocessingnegativeregulationofmRNAsplicingviaspliceosomepositiveregulationofRNAsplicingregulationofalternativemRNAsplicingviaspliceosomeregulationofmRNAsplicingviaspliceosomeregulationofRNAsplicingRNAsplicing
Elongation factor 1-gamma
9.8
76
27
✔
EF1GEF1GP26641P26641responsetovirustranslationalelongation
mitochondrial sodium/hydrogen exchanger 9B2
9.8
71
32
A0A6P3HVI0A0A6P3HVI0A0A6P3HVI0A0A6P3HVI0
Protein Aster-C
9.8
63
34
ASTRCASTRCQ8IYS0Q8IYS0cellularresponsetocholesterolintracellularsteroltransport
Actin-histidine N-methyltransferase
6.1
nan
64
SETD3SETD3Q86TU7Q86TU7actinmodificationpeptidyl-histidinemethylationpeptidyl-lysinedimethylationpeptidyl-lysinemonomethylationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofmusclecelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofuterinesmoothmusclecontraction
DnaJ homolog subfamily B member 1
9.8
57
37
DNJB1DNJB1P25685P25685cellularresponsetoheatchaperonecofactor-dependentproteinrefoldingforebraindevelopmentnegativeregulationofinclusionbodyassemblynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofATP-dependentactivityregulationofcellularresponsetoheatresponsetounfoldedprotein
Cullin-4A
9.8
60
33
CUL4ACUL4AQ13619Q13619cellpopulationproliferationcellularresponsetoDNAdamagestimuluscellularresponsetoUVDNArepairG1/StransitionofmitoticcellcyclehemopoiesisinuteroembryonicdevelopmentintrinsicapoptoticsignalingpathwaynegativeregulationofgranulocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofG1/Stransitionofmitoticcellcycleproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationregulationofDNAdamagecheckpointregulationofnucleotide-excisionrepairregulationofproteinmetabolicprocessrhythmicprocessribosomebiogenesisSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocesssomaticstemcellpopulationmaintenance
Ubiquilin-3
9.8
58
40
UBQL3UBQL3Q9H347Q9H347cellularresponsetostressregulationofproteasomalubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocess
Synaptic vesicle glycoprotein 2C
9.8
71
32
SV2CSV2CQ496J9Q496J9chemicalsynaptictransmissionneurotransmittertransportregulationofsynapticvesicleexocytosis
40S ribosomal protein S3
9.8
72
36
G1TNM3G1TNM3G1TNM3G1TNM3apoptoticprocesscelldivisionDNArepairpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofprotein-containingcomplexassemblyregulationoftranslationtranslation
Band 4.1-like protein 3
4.8
56
70
E41L3E41L3Q9Y2J2Q9Y2J2actomyosinstructureorganizationapoptoticprocesscorticalactincytoskeletonorganizationcorticalcytoskeletonorganizationmyelinmaintenanceneuronprojectionmorphogenesisparanodaljunctionassemblyproteinlocalizationtojuxtaparanoderegionofaxonproteinlocalizationtoparanoderegionofaxonproteinlocalizationtoplasmamembraneregulationofcellshape
NEDD8-activating enzyme E1 regulatory subunit
9.8
73
33
ULA1ULA1Q13564Q13564mitoticDNAreplicationcheckpointsignalingneuronapoptoticprocessproteinmodificationbysmallproteinconjugationproteinneddylationregulationofapoptoticprocessregulationofneuronapoptoticprocesssignaltransduction
Serine/threonine-protein kinase VRK1
3.7
82
72
VRK1VRK1Q99986Q99986celldivisioncellularresponsetoDNAdamagestimulusGolgidisassemblymitoticnuclearmembranedisassemblypeptidyl-serinephosphorylationpositiveregulationofproteinlocalizationtochromatinproteinautophosphorylationproteinphosphorylationsignaltransduction
Plastin-3
9.8
72
35
PLSTPLSTP13797P13797actinfilamentbundleassemblyactinfilamentnetworkformationbonedevelopment
Aspartate aminotransferase, cytoplasmic
9.8
95
23
AATCAATCP17174P171742-oxoglutaratemetabolicprocessaspartatebiosyntheticprocessaspartatecatabolicprocessaspartatemetabolicprocesscellularresponsetoinsulinstimulusfattyacidhomeostasisgluconeogenesisglutamatecatabolicprocessto2-oxoglutarateglutamatecatabolicprocesstoaspartateglutamatemetabolicprocessglycerolbiosyntheticprocessNotchsignalingpathwayoxaloacetatemetabolicprocessresponsetoglucocorticoid
Mitotic spindle assembly checkpoint protein MAD2B
10.0
59
37
MD2L2REV3LQ9UI95O60673actinfilamentorganizationcelldivisionDNAdamageresponsesignaltransductionresultingintranscriptiondouble-strandbreakrepairerror-pronetranslesionsynthesismitoticspindleassemblycheckpointsignalingnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcell-celladhesionmediatedbycadherinnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofdouble-strandbreakrepairviahomologousrecombinationnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofproteincatabolicprocessnegativeregulationoftranscriptionbycompetitivepromoterbindingnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionregulatoryregionDNAbindingnegativeregulationofubiquitinproteinligaseactivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofextracellularmatrixassemblypositiveregulationofisotypeswitchingpositiveregulationofpeptidyl-serinephosphorylationregulationofcellgrowthsomaticdiversificationofimmunoglobulinsinvolvedinimmuneresponsetelomeremaintenanceinresponsetoDNAdamageDNA-templatedDNAreplicationdouble-strandbreakrepairviahomologousrecombination
B-cell lymphoma/leukemia 10
9.8
45
43
BCL10BCL10O95999O95999adaptiveimmuneresponseantifungalinnateimmuneresponseBcellapoptoticprocesscelldeathcellulardefenseresponsecellularresponsetolipopolysaccharidecellularresponsetomechanicalstimulusI-kappaBkinase/NF-kappaBsignalingimmunoglobulinmediatedimmuneresponseinnateimmuneresponselipopolysaccharide-mediatedsignalingpathwaynegativeregulationofmatureBcellapoptoticprocessneuraltubeclosurepositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationoflymphotoxinAproductionpositiveregulationofmastcellcytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofphosphorylationpositiveregulationofproteinubiquitinationpositiveregulationofTcellactivationpositiveregulationofTcellreceptorsignalingpathwayproteinhomooligomerizationresponsetofoodTcellapoptoticprocessTcellreceptorsignalingpathwaytoll-likereceptorsignalingpathway
Proteasome subunit beta type-3
6.1
72
44
PSB7PSB3P70195Q9R1P1proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteincatabolicprocess
RNA polymerase II subunit D
9.8
75
30
A0A287ADR4A0A287ADR4A0A287ADR4A0A287ADR4mRNAexportfromnucleusinresponsetoheatstressnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationoftranslationalinitiation"recruitmentof3-endprocessingfactorstoRNApolymeraseIIholoenzymecomplex"transcriptioninitiationatRNApolymeraseIIpromoter
Steroid 17-alpha-hydroxylase/17,20 lyase
9.8
65
31
CP17ACP17AP05093P05093androgenbiosyntheticprocessglucocorticoidbiosyntheticprocesshormonebiosyntheticprocessprogesteronemetabolicprocesssexdifferentiationsteroidbiosyntheticprocesssteroidmetabolicprocess
Unconventional myosin-Ib
9.8
78
25
MYO1BMYO1BQ05096Q05096actinfilamentbundleassemblyactinfilamentorganizationactinfilament-basedmovementnervoussystemdevelopmentpost-Golgivesicle-mediatedtransporttransferrintransportvesicletransportalongactinfilament
Host cell factor 1
9.8
48
40
HCFC1HCFC1Q61191Q61191blastocysthatchingcellcyclechromatinremodelinghistoneH4-K16acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofhistoneH3-K4methylationpositiveregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationregulationofDNA-templatedtranscriptionregulationofdosagecompensationbyinactivationofXchromosomeregulationofprotein-containingcomplexassemblyreleasefromvirallatency
Nuclear transport factor 2
7.3
67
47
NTF2NTF2P61972P61972mRNAtransportnegativeregulationofvascularendothelialgrowthfactorproductionnucleocytoplasmictransportpositiveregulationofproteinimportintonucleusproteinexportfromnucleusproteinimportintonucleusproteinlocalizationtonuclearpore
TNF receptor-associated factor 1
9.8
84
26
TRAF1TRAF1Q13077Q13077apoptoticprocesspositiveregulationofJNKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivityproteinK63-linkedubiquitinationprotein-containingcomplexassemblyregulationofextrinsicapoptoticsignalingpathwayregulationofI-kappaBkinase/NF-kappaBsignalingtumornecrosisfactor-mediatedsignalingpathway
Protein rogdi homolog
9.8
65
36
ROGDIROGDIQ9GZN7Q9GZN7braindevelopmenthemopoiesisneurogenesisodontogenesisofdentin-containingtoothpositiveregulationofcellpopulationproliferation
Adenosine receptor A2b
2.0
60
86
AA2BRAA2BRP29275P29275activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetoextracellularstimuluscGMP-mediatedsignalingGprotein-coupledreceptorsignalingpathwaymastcelldegranulationpositiveregulationofcGMP-mediatedsignalingpositiveregulationofchemokineproductionpositiveregulationofchronicinflammatoryresponsetonon-antigenicstimuluspositiveregulationofguanylatecyclaseactivitypositiveregulationofinterleukin-6productionpositiveregulationofmastcelldegranulationpositiveregulationofvascularendothelialgrowthfactorproductionpresynapticmodulationofchemicalsynaptictransmissionrelaxationofvascularassociatedsmoothmusclevasodilation
NADH-cytochrome b5 reductase 3
3.4
72
87
NB5R3NB5R3P83686P83686cholesterolbiosyntheticprocess
Isocitrate dehydrogenase [NADP] cytoplasmic
3.7
69
75
✔
IDHCIDHCO75874O758742-oxoglutaratemetabolicprocessfemalegonaddevelopmentglutathionemetabolicprocessglyoxylatecycleisocitratemetabolicprocessNADPmetabolicprocessregulationofphospholipidbiosyntheticprocessregulationofphospholipidcatabolicprocessresponsetooxidativestressresponsetosteroidhormonetricarboxylicacidcycle
Ribosyldihydronicotinamide dehydrogenase [quinone]
9.8
81
26
NQO2NQO2P16083P16083quinonecatabolicprocess
Cytoskeleton-associated protein 5
9.8
74
34
CKAP5CKAP5Q14008Q14008celldivisioncentrosomecyclecentrosomeduplicationestablishmentormaintenanceofmicrotubulecytoskeletonpolaritymicrotubuledepolymerizationmicrotubulepolymerizationmitoticspindleorganizationpositiveregulationofmicrotubulenucleationRNAtransportspindleorganization
Beta-2 adrenergic receptor
3.8
62
76
ADRB2ADRB2P07550P07550activationofadenylatecyclaseactivityactivationoftransmembranereceptorproteintyrosinekinaseactivityadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwayadrenergicreceptorsignalingpathwayboneresorptionbrownfatcelldifferentiationcellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betadesensitizationofGprotein-coupledreceptorsignalingpathwaybyarrestindietinducedthermogenesisendosometolysosometransportheatgenerationnegativeregulationofmulticellularorganismgrowthnegativeregulationofsmoothmusclecontractionnorepinephrine-epinephrine-mediatedvasodilationinvolvedinregulationofsystemicarterialbloodpressurepositiveregulationofAMPAreceptoractivitypositiveregulationofautophagosomematurationpositiveregulationofbonemineralizationpositiveregulationofcAMP-dependentproteinkinaseactivitypositiveregulationofcold-inducedthermogenesispositiveregulationoflipophagypositiveregulationofMAPKcascadepositiveregulationofminiexcitatorypostsynapticpotentialpositiveregulationofproteinkinaseAsignalingpositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIreceptor-mediatedendocytosisregulationofsodiumiontransportresponsetocoldresponsetopsychosocialstresssmoothmusclecontractiontranscriptionbyRNApolymeraseII
Eukaryotic initiation factor 4A-III
9.8
86
27
IF4A3IF4A3P38919P38919associativelearningcellularresponsetobrain-derivedneurotrophicfactorstimuluscellularresponsetoseleniteionembryoniccranialskeletonmorphogenesisexplorationbehaviormRNAexportfromnucleusmRNAsplicingviaspliceosomenegativeregulationofexcitatorypostsynapticpotentialnegativeregulationofselenocysteineincorporationnegativeregulationofselenocysteineinsertionsequencebindingnegativeregulationoftranslationnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaypositiveregulationoftranslationregulationofnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecayregulationoftranslationatpostsynapsemodulatingsynaptictransmissionresponsetoorganiccycliccompoundrRNAprocessing
Apoptosis regulator Bcl-2 homolog
9.8
56
37
D0Q0E8F1RIQ4D0Q0E8F1RIQ4suppressionbyvirusofhostapoptoticprocessextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagemitochondrialfusionpositiveregulationofapoptoticprocessreleaseofcytochromecfrommitochondria
Solute carrier family 2, facilitated glucose transporter member 4
9.8
74
33
GLUT4GLUT4P14672P14672amylopectinbiosyntheticprocessbrownfatcelldifferentiationcarbohydratemetabolicprocesscellularresponsetohypoxiacellularresponsetoinsulinstimuluscellularresponsetoosmoticstresscellularresponsetotumornecrosisfactorglucosehomeostasisglucoseimportglucoseimportinresponsetoinsulinstimulusglucosetransmembranetransportlearningormemorylong-termmemorymonosaccharidetransmembranetransportpositiveregulationofbrain-derivedneurotrophicfactorreceptorsignalingpathwayregulationofsynapticvesiclebuddingfrompresynapticendocyticzonemembraneresponsetoethanolshort-termmemorytransportacrossblood-brainbarrier
Myosin VI
9.8
50
42
Q5JVM0Q5JVM0Q5JVM0Q5JVM0
39S ribosomal protein L19, mitochondrial
9.8
82
27
✔
RM19RM19P49406P49406mitochondrialtranslation
Inositol polyphosphate multikinase
9.8
59
41
IPMKIPMKQ8NFU5Q8NFU5inositolphosphatebiosyntheticprocessinositolphosphatemetabolicprocessinositoltrisphosphatemetabolicprocessnecroptoticprocessphosphorylation
Inward rectifier potassium channel 2
9.8
55
36
KCNJ2KCNJ2P63252P63252cardiacmusclecellactionpotentialinvolvedincontractioncellularpotassiumionhomeostasiscellularresponsetomechanicalstimulusmagnesiumiontransportmembranedepolarizationduringcardiacmusclecellactionpotentialmembranerepolarizationduringactionpotentialmembranerepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofpotassiumiontransmembranetransportpotassiumionimportacrossplasmamembranepotassiumiontransmembranetransportpotassiumiontransportproteinhomotetramerizationregulationofcardiacmusclecellcontractionregulationofheartratebycardiacconductionregulationofiontransmembranetransportregulationofmembranerepolarizationregulationofrestingmembranepotentialregulationofskeletalmusclecontractionviaregulationofactionpotentialrelaxationofcardiacmusclerelaxationofskeletalmuscle
Methylglutaconyl-CoA hydratase, mitochondrial
9.8
86
25
AUHMAUHMQ13825Q13825fattyacidbeta-oxidationleucinecatabolicprocess
40S ribosomal protein S3
9.8
78
33
RS3RS3P23396P23396apoptoticprocesscelldivisioncellularresponsetoDNAdamagestimuluscellularresponsetohydrogenperoxidecellularresponsetoreactiveoxygenspeciescellularresponsetotumornecrosisfactorchromosomesegregationcytoplasmictranslationDNArepairnegativeregulationofDNArepairnegativeregulationofproteinubiquitinationnegativeregulationoftranslationpositiveregulationofactivatedTcellproliferationpositiveregulationofapoptoticsignalingpathwaypositiveregulationofbase-excisionrepairpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinexecutionphaseofapoptosispositiveregulationofDNAN-glycosylaseactivitypositiveregulationofDNArepairpositiveregulationofendodeoxyribonucleaseactivitypositiveregulationofgeneexpressionpositiveregulationofinterleukin-2productionpositiveregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagepositiveregulationofJUNkinaseactivitypositiveregulationofmicrotubulepolymerizationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofprotein-containingcomplexassemblypositiveregulationofTcellreceptorsignalingpathwayregulationofapoptoticprocessresponsetoTNFagonistspindleassemblytranslationtranslationalinitiation
RNA-binding protein 14
9.8
55
44
RBM14RBM14Q96PK6Q96PK6activationofinnateimmuneresponsecentrioleassemblyhistonedeacetylationinnateimmuneresponsemRNAsplicingviaspliceosomenegativeregulationofcentriolereplicationpositiveregulationoftranscriptionbyRNApolymeraseIIresponsetohormoneSMADproteinsignaltransduction
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
9.8
73
36
I3LG77I3LG77I3LG77I3LG77dATPcatabolicprocessdefenseresponsetovirusdGTPcatabolicprocessDNAstrandresectioninvolvedinreplicationforkprocessingdouble-strandbreakrepairviahomologousrecombinationnegativeregulationoftypeIinterferon-mediatedsignalingpathwayproteinhomotetramerizationregulationofinnateimmuneresponsesomatichypermutationofimmunoglobulingenes
Inosine-5'-monophosphate dehydrogenase 2
7.5
70
46
✔
IMDH2IMDH2P12269P12269"denovoXMPbiosyntheticprocess"cellularresponsetointerleukin-4circadianrhythmGMPbiosyntheticprocessGTPbiosyntheticprocesslymphocyteproliferation
39S ribosomal protein L20, mitochondrial
9.8
84
28
RM20RM42Q9BYC9Q9Y6G3mitochondrialtranslationribosomallargesubunitassemblytranslation
Programmed cell death protein 4
9.8
54
43
✔
PDCD4PDCD4Q53EL6Q53EL6apoptoticprocessBMPsignalingpathwaycellularresponsetolipopolysaccharideepithelialtomesenchymaltransitioninvolvedincardiacfibroblastdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofDNA-templatedtranscriptionnegativeregulationofJUNkinaseactivitynegativeregulationofmyofibroblastdifferentiationnegativeregulationofvascularassociatedsmoothmusclecelldifferentiationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofinflammatoryresponsepositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofvascularassociatedsmoothmusclecellapoptoticprocess
Kelch-like protein 40
9.8
68
38
KLH40KLH40Q2TBA0Q2TBA0negativeregulationofproteasomalubiquitin-dependentproteincatabolicprocessnegativeregulationofproteinubiquitinationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationskeletalmusclefiberdevelopmentskeletalmusclefiberdifferentiation
Cytochrome P450
9.8
77
23
J9JD75J9JD75J9JD75J9JD75
Syntaxin-binding protein 3
5.0
62
61
STXB3STXB3Q60770Q60770braindevelopmentcellularglucosehomeostasiscellularresponsetotypeIIinterferonexocytosisinsulinsecretionintracellularproteintransportnegativeregulationofcalciumion-dependentexocytosisnegativeregulationofglucoseimportneurotransmittersecretionneutrophildegranulationplateletaggregationproteintomembranedockingresponsetoinsulinvesicledockinginvolvedinexocytosisvesicle-mediatedtransport
Mediator of RNA polymerase II transcription subunit 25
9.8
83
30
MED25MED25Q71SY5Q71SY5negativeregulationoffibroblastproliferationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofchromatinbindingpositiveregulationofmediatorcomplexassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassembly
Negative elongation factor C/D
6.7
65
52
✔
NELFDNELFDQ8IXH7Q8IXH7negativeregulationoftranscriptionelongationbyRNApolymeraseII
Male-specific lethal 1 homolog
9.8
55
36
✔
MSL1MSL2Q68DK7Q9HCI7chromatinorganizationhistoneH4-K16acetylationpositiveregulationofDNA-templatedtranscriptionregulationofdosagecompensationbyinactivationofXchromosomeproteinubiquitination
Glutamate receptor-interacting protein 2
9.8
53
38
GRIP2GRIP2Q9C0E4Q9C0E4arterysmoothmusclecontractionneurotransmitterreceptortransportendosometopostsynapticmembraneNotchsignalingpathwaypositiveregulationofbloodpressurevesicle-mediatedtransportinsynapse
Vesicle-fusing ATPase
9.6
75
35
NSFNSFP18708P18708intracellularproteintransportpositiveregulationofproteincatabolicprocesspositiveregulationofreceptorrecyclingpotassiumiontransportSNAREcomplexdisassembly
DNA fragmentation factor subunit beta
3.9
59
77
✔
DFFBDFFBO54788O54788apoptoticchromosomecondensationapoptoticDNAfragmentationDNAcatabolicprocessnegativeregulationofapoptoticDNAfragmentation
Cullin-1
8.2
68
44
CUL1CUL1Q13616Q13616animalorganmorphogenesiscellpopulationproliferationG1/StransitionofmitoticcellcycleintrinsicapoptoticsignalingpathwayproteinK48-linkedubiquitinationproteinmonoubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Serine/threonine-protein kinase 16
9.9
45
40
STK16STK16O75716O75716cellularresponsetotransforminggrowthfactorbetastimuluspositiveregulationoftranscriptionbyRNApolymeraseIIproteinautophosphorylation
Protein kinase C
8.8
53
41
L7RSM7L7RSM7L7RSM7L7RSM7proteinphosphorylation
N-lysine methyltransferase SETD6
9.9
49
40
SETD6SETD6Q8TBK2Q8TBK2negativeregulationofNF-kappaBtranscriptionfactoractivitypeptidyl-lysinemonomethylationregulationofinflammatoryresponsestemcelldifferentiationstemcellpopulationmaintenance
Tumor necrosis factor ligand superfamily member 13
9.6
88
31
TNF13TNF13Q9D777Q9D777germinalcenterformationimmunoglobulinmediatedimmuneresponsepositiveregulationofcellpopulationproliferationpositiveregulationofgerminalcenterformationpositiveregulationofisotypeswitchingtoIgAisotypesregulationofimmuneresponse
Tyrosine-protein kinase ABL1
9.9
62
35
ABL1ABL1P00519P00519actincytoskeletonorganizationactinfilamentpolymerizationactivatedTcellproliferationactivationofproteinkinaseCactivityalpha-betaTcelldifferentiationassociativelearningautophagyBcellproliferationinvolvedinimmuneresponseBcellreceptorsignalingpathwayB-1BcellhomeostasisBergmannglialcelldifferentiationBMPsignalingpathwaycardiacmusclecellproliferationcell-celladhesioncellularresponsetoDNAdamagestimuluscellularresponsetodopaminecellularresponsetohydrogenperoxidecellularresponsetolipopolysaccharidecellularresponsetooxidativestresscellularresponsetotransforminggrowthfactorbetastimuluscellularsenescencecerebellummorphogenesisDN4thymocytedifferentiationDNAconformationchangeendocytosisendothelialcellmigrationepidermalgrowthfactorreceptorsignalingpathwayERK1andERK2cascadeestablishmentoflocalizationincellFc-gammareceptorsignalingpathwayinvolvedinphagocytosisI-kappaBkinase/NF-kappaBsignalingintegrin-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagemicrospikeassemblymismatchrepairmitochondrialdepolarizationmitoticcellcyclemyoblastproliferationnegativeregulationofBMPsignalingpathwaynegativeregulationofcell-celladhesionnegativeregulationofcellularsenescencenegativeregulationofendothelialcellapoptoticprocessnegativeregulationofERK1andERK2cascadenegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationoflong-termsynapticpotentiationnegativeregulationofmitoticcellcyclenegativeregulationofphospholipaseCactivitynegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofubiquitin-proteintransferaseactivityneuraltubeclosureneuroepithelialcelldifferentiationneuromuscularprocesscontrollingbalanceneurondeathneurondifferentiationneuropilinsignalingpathwaypeptidyl-tyrosineautophosphorylationpeptidyl-tyrosinephosphorylationplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypodocyteapoptoticprocesspositiveregulationofactincytoskeletonreorganizationpositiveregulationofactinfilamentbindingpositiveregulationofapoptoticprocesspositiveregulationofbloodvesselbranchingpositiveregulationofcellmigrationinvolvedinsproutingangiogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendritedevelopmentpositiveregulationofendothelialcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofestablishmentofTcellpolaritypositiveregulationofextracellularmatrixorganizationpositiveregulationoffibroblastproliferationpositiveregulationoffocaladhesionassemblypositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofmicrotubulebindingpositiveregulationofmitoticcellcyclepositiveregulationofneuronapoptoticprocesspositiveregulationofosteoblastproliferationpositiveregulationofoxidoreductaseactivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingpositiveregulationofTcellmigrationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionpositiveregulationofvasoconstrictionpositiveregulationofWntsignalingpathwayplanarcellpolaritypathwaypost-embryonicdevelopmentproteinautophosphorylationproteinlocalizationtocytoplasmicmicrotubuleplus-endproteinmodificationprocessproteinphosphorylationregulationofactincytoskeletonorganizationregulationofactincytoskeletonreorganizationregulationofapoptoticprocessregulationofautophagyregulationofaxonextensionregulationofCdc42proteinsignaltransductionregulationofcelladhesionregulationofcellcycleregulationofcellmotilityregulationofDNA-templatedtranscriptionregulationofendocytosisregulationofhematopoieticstemcelldifferentiationregulationofmicrotubulepolymerizationregulationofmodificationofsynapticstructureregulationofresponsetoDNAdamagestimulusregulationofTcelldifferentiationresponsetoendoplasmicreticulumstressresponsetoepinephrineresponsetooxidativestressresponsetoxenobioticstimulussignaltransductioninresponsetoDNAdamagespleendevelopmentsubstrateadhesion-dependentcellspreadingTcellreceptorsignalingpathwaythymusdevelopmenttransitionalonestageBcelldifferentiation
Nuclear pore complex protein Nup50
9.9
55
40
NUP50NUP50Q9UKX7Q9UKX7mRNAtransportnucleocytoplasmictransportproteinimportintonucleus
Calbindin
7.3
45
59
CALB1CALB1P05937P05937cellularresponsetoorganicsubstancecochleadevelopmentlocomotorybehaviorlong-termmemorymetanephriccollectingductdevelopmentmetanephricconnectingtubuledevelopmentmetanephricdistalconvolutedtubuledevelopmentmetanephricpartofuretericbuddevelopmentregulationofcytosoliccalciumionconcentrationregulationoflong-termsynapticpotentiationregulationofpresynapticcytosoliccalciumionconcentrationretinalayerformationshort-termmemory
Glucose-6-phosphate 1-dehydrogenase
2.0
44
85
✔
G6PDG6PDP11413P11413cellularresponsetooxidativestresscholesterolbiosyntheticprocesserythrocytematurationglucose6-phosphatemetabolicprocessglucosemetabolicprocessglutathionemetabolicprocesslipidmetabolicprocessNADPmetabolicprocessNADPHregenerationnegativeregulationofcellgrowthinvolvedincardiacmusclecelldevelopmentnegativeregulationofproteinglutathionylationnegativeregulationofreactiveoxygenspeciesmetabolicprocesspentosebiosyntheticprocesspentose-phosphateshuntpentose-phosphateshuntoxidativebranchpositiveregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofneuronapoptoticprocessresponsetoethanolresponsetofoodresponsetoiron(III)ionresponsetoorganiccycliccompoundribosephosphatebiosyntheticprocesssubstantianigradevelopment
PR domain zinc finger protein 10
9.9
46
43
PRD10PRD10Q9NQV6Q9NQV6methylationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpression
Neuronal PAS domain-containing protein 3
9.9
63
35
NPAS3NPAS3Q9QZQ0Q9QZQ0locomotorybehaviormaternalbehaviorpositiveregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIstartleresponse
Beta-lactoglobulin-1/B
2.0
49
87
✔
LACBLACBP67976P67976
Bardet-Biedl syndrome 9
5.2
51
68
E1BHJ5E1BHJ5E1BHJ5E1BHJ5ciliumassemblyproteinlocalizationtocilium
Nucleosome assembly protein 1-like 1
9.9
61
38
✔
NP1L1NP1L1P55209P55209DNAreplicationnervoussystemdevelopmentnucleosomeassemblypositiveregulationofcellpopulationproliferationpositiveregulationofneuralprecursorcellproliferationpositiveregulationofneurogenesis
Transgelin-2
9.9
69
34
TAGL2TAGL2P37802P37802epithelialcelldifferentiation
Fanconi anemia group M protein
7.6
61
45
FANCMFANCMQ8IYD8Q8IYD8double-strandbreakrepairviasynthesis-dependentstrandannealinginterstrandcross-linkrepairpositiveregulationofproteinmonoubiquitinationreplicationforkprocessingreplicationforkreversalresolutionofmeioticrecombinationintermediates
Cell division cycle protein 16 homolog
7.2
nan
56
CDC16CDC16Q13042Q13042anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionmetaphase/anaphasetransitionofmitoticcellcyclepositiveregulationofmitoticmetaphase/anaphasetransitionproteinK11-linkedubiquitinationproteinubiquitinationregulationofmeioticcellcycleregulationofmitoticcellcycle
28S ribosomal protein S7, mitochondrial
9.9
74
31
✔
RT07RT07Q9Y2R9Q9Y2R9mitochondrialtranslationribosomalsmallsubunitassemblytranslation
Transcriptional enhancer factor TEF-3
9.9
76
27
TEAD4TEAD4Q62296Q62296blastocystformationcellfatecommitmentcellfatespecificationembryoimplantationembryonicorgandevelopmenthipposignalinginuteroembryonicdevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIItrophectodermalcellfatecommitment
Centromere protein T
9.0
61
42
CENPICENPTQ92674Q96BT3centromerecomplexassemblysexdifferentiationcelldivisionchromosomeorganizationchromosomesegregationkinetochoreassemblymitoticcellcycle
Docking protein 1
9.9
47
44
DOK1DOK1Q53TY2Q53TY2cellsurfacereceptorsignalingpathwaymacrophagecolony-stimulatingfactorsignalingpathwayRasproteinsignaltransductionsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
Cullin-3
8.0
63
45
CUL3CUL3Q13618Q13618anaphase-promotingcomplex-dependentcatabolicprocesscellmigrationcellprojectionorganizationCOPIIvesiclecoatingembryoniccleavageendoplasmicreticulumtoGolgivesicle-mediatedtransportfibroblastapoptoticprocessG1/Stransitionofmitoticcellcyclegastrulationgeneexpressioninflammatoryresponseintegrin-mediatedsignalingpathwayintrinsicapoptoticsignalingpathwaylivermorphogenesismitoticmetaphaseplatecongressionnegativeregulationofRhoproteinsignaltransductionnegativeregulationoftranscriptionbyRNApolymeraseIInuclearproteinqualitycontrolbytheubiquitin-proteasomesystempositiveregulationofcellpopulationproliferationpositiveregulationofcytokinesispositiveregulationofmitoticcellcyclephasetransitionpositiveregulationofmitoticmetaphase/anaphasetransitionpositiveregulationofproteinubiquitinationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautoubiquitinationproteindestabilizationproteinK48-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationproteincatabolicprocessatpostsynapsestemcelldivisionstressfiberassemblytrophectodermalcellularmorphogenesisubiquitin-dependentproteincatabolicprocessWntsignalingpathway
eEF1A lysine and N-terminal methyltransferase
9.9
58
39
✔
EFNMTEFNMTQ8N6R0Q8N6R0negativeregulationofcellcycleG1/SphasetransitionnegativeregulationoftranscriptionbyRNApolymeraseII
Replication protein A 14 kDa subunit
9.9
79
27
RFA3RFA3P35244P35244base-excisionrepairDNArepairDNAreplicationdouble-strandbreakrepairviahomologousrecombinationmismatchrepairnucleotide-excisionrepairregulationofcellpopulationproliferationregulationofmitoticcellcycletelomeremaintenance
Heat shock 70 kDa protein 1A
9.9
68
31
HS71AHS71AP0DMV8P0DMV8ATPmetabolicprocesscellularheatacclimationcellularresponsetoheatcellularresponsetooxidativestresscellularresponsetosteroidhormonestimuluscellularresponsetounfoldedproteinchaperonecofactor-dependentproteinrefoldingchaperone-mediatedproteincomplexassemblylysosomaltransportmRNAcatabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofcelldeathnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofinclusionbodyassemblynegativeregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwaynegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofendoribonucleaseactivitypositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofinterleukin-8productionpositiveregulationofmicrotubulenucleationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofRNAsplicingpositiveregulationoftumornecrosisfactor-mediatedsignalingpathwayproteinrefoldingproteinstabilizationregulationofmitoticspindleassemblyregulationofproteinubiquitinationresponsetounfoldedproteinvesicle-mediatedtransport
ABO glycosyltransferase
9.9
70
32
Q70V26Q70V26Q70V26Q70V26carbohydratemetabolicprocess
Snurportin-1
5.3
67
59
XPO1SPN1Q6P5F9O95149mRNAtransportnegativeregulationoftranscriptionbyRNApolymeraseIInucleocytoplasmictransportproteinexportfromnucleusproteinlocalizationtonucleusregulationofcentrosomeduplicationregulationofproteasomalubiquitin-dependentproteincatabolicprocessregulationofproteincatabolicprocessregulationofproteinexportfromnucleusribosomallargesubunitexportfromnucleusribosomalsmallsubunitexportfromnucleusribosomalsubunitexportfromnucleusribosomebiogenesisproteinimportintonucleusRNAimportintonucleussnRNAimportintonucleus
Mediator of RNA polymerase II transcription subunit 4
9.9
75
31
MED4MED26Q9NPJ6O95402positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressiontranscriptioninitiationatRNApolymeraseIIpromoter
Ubiquitin thioesterase OTUB1
9.9
74
32
OTUB1OTUB1Q96FW1Q96FW1adaptiveimmuneresponsecellularresponsetoDNAdamagestimulusDNArepairnegativeregulationofdouble-strandbreakrepairnegativeregulationofhistoneH2AK63-linkedubiquitinationproteinK48-linkeddeubiquitination
A-kinase anchor protein 13
9.9
80
28
✔
AKP13AKP13Q12802Q12802adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessadrenergicreceptorsignalingpathwaybonedevelopmentcardiacmusclecelldifferentiationcellgrowthinvolvedincardiacmusclecelldevelopmentGprotein-coupledreceptorsignalingpathwayheartdevelopmentnuclearexportpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofMAPkinaseactivitypositiveregulationofRhoproteinsignaltransductionregulationofRhoproteinsignaltransductionregulationofsarcomereorganizationregulationofsmallGTPasemediatedsignaltransduction
Transcription regulator protein BACH1
9.4
67
41
BACH1BACH1O14867O14867DNArepairnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationofmetabolicprocessregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcycleregulationoftranscriptioninvolvedinG2/Mtransitionofmitoticcellcycle
Growth factor receptor-bound protein 14
9.9
80
28
GRB14GRB14Q14449Q14449insulinreceptorsignalingpathwaynegativeregulationofinsulinreceptorsignalingpathwaysignaltransduction
Glycogen phosphorylase, muscle form
9.9
73
32
PYGMPYGMP00489P00489glycogencatabolicprocess
Phosphatidylinositol 3-kinase regulatory subunit alpha
4.9
72
65
P85AP85AP23727P23727BcelldifferentiationcellularglucosehomeostasiscellularresponsetoinsulinstimuluscellularresponsetoUVextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsgrowthhormonereceptorsignalingpathwayinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagemyeloidleukocytemigrationnegativeregulationofapoptoticprocessnegativeregulationofcell-matrixadhesionnegativeregulationofosteoclastdifferentiationnegativeregulationofstressfiberassemblyosteoclastdifferentiationphosphatidylinositol3-kinasesignalingphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationoffilopodiumassemblypositiveregulationoffocaladhesiondisassemblypositiveregulationofglucoseimportpositiveregulationoflamellipodiumassemblypositiveregulationofleukocytemigrationpositiveregulationofproteinimportintonucleuspositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofRNAsplicingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinimportintonucleusproteinphosphorylationproteinstabilizationregulationofinsulinreceptorsignalingpathwayregulationofphosphatidylinositol3-kinaseactivityresponsetoendoplasmicreticulumstresssubstrateadhesion-dependentcellspreadingtranscriptionbyRNApolymeraseII
SR-related and CTD-associated factor 8
10.0
54
40
SCAF8SCAF8Q9UPN6Q9UPN6mRNApolyadenylationnegativeregulationofterminationofRNApolymeraseIItranscriptionpoly(A)-coupledpositiveregulationofDNA-templatedtranscriptionelongationterminationofRNApolymeraseIItranscription
Centrosomal protein of 152 kDa
10.0
38
39
CE152CE152O94986O94986cellprojectionorganizationcentriolereplicationcentrosomeduplicationdenovocentrioleassemblyinvolvedinmulti-ciliatedepithelialcelldifferentiation
Transaldolase
10.0
100
25
TALDOTALDOP37837P37837carbohydratemetabolicprocessfructose6-phosphatemetabolicprocessglyceraldehyde-3-phosphatemetabolicprocesspentose-phosphateshuntnon-oxidativebranch
Menin
10.0
71
29
A0A024R5E3A0A024R5E3A0A024R5E3A0A024R5E3
Palmitoyltransferase ZDHHC17
10.0
83
25
ZDH17ZDH17Q8IUH5Q8IUH5axonogenesislipoproteintransportpeptidyl-L-cysteineS-palmitoylationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingproteinpalmitoylationregulationofERK1andERK2cascaderegulationofneurotrophinTRKreceptorsignalingpathway
Mitochondrial peptide methionine sulfoxide reductase
8.7
59
41
MSRAMSRAQ9D6Y7Q9D6Y7agingcellularresponsetooxidativestress
Caseinolytic peptidase B protein homolog
10.0
63
38
CLPBCLPBQ9H078Q9H078antiviralinnateimmuneresponsecellularresponsetoheatgranulocytedifferentiationRIG-Isignalingpathway
Microtubule-associated serine/threonine-protein kinase 1
10.0
68
23
MAST1MAST1Q9Y2H9Q9Y2H9braindevelopmentcytoskeletonorganizationintracellularsignaltransductionpeptidyl-serinephosphorylationproteinphosphorylation
Neuralized-like protein 4
10.0
53
38
NEUL4NEUL4Q96JN8Q96JN8
Eukaryotic translation initiation factor 4E
10.0
74
35
IF4EIF4EP06730P06730behavioralfearresponsecellularresponsetodexamethasonestimulusG1/Stransitionofmitoticcellcyclenegativeregulationofneurondifferentiationnegativeregulationoftranslationneurondifferentiationpositiveregulationofmitoticcellcycleregulationoftranslationregulationoftranslationatpostsynapsemodulatingsynaptictransmissionstemcellpopulationmaintenancetranslationalinitiation
Protein FAM83A
10.0
53
36
FA83AFA83AQ86UY5Q86UY5cellpopulationproliferationepidermalgrowthfactorreceptorsignalingpathwaysignaltransduction
Coatomer subunit epsilon
10.0
69
31
COPECOPAQ28104Q27954endoplasmicreticulumtoGolgivesicle-mediatedtransportintra-Golgivesicle-mediatedtransportproteinlocalizationtoaxonproteintransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumintracellularproteintransport
Intraflagellar transport protein 25 homolog
10.0
78
29
IFT25IFT25Q9Y547Q9Y547celldifferentiationciliumassemblyheartdevelopmentintraciliaryanterogradetransportkidneydevelopmentleft/rightaxisspecificationlungdevelopmentproteintransportskeletalsystemdevelopmentsmoothenedsignalingpathwayspermatogenesis
Ferritin heavy chain
7.0
51
54
FRIHFRIHP02794P02794cellularironionhomeostasisimmuneresponseintracellularsequesteringofironionironiontransportnegativeregulationofcellpopulationproliferationnegativeregulationoffibroblastproliferation
Dimethyladenosine transferase 1, mitochondrial
10.0
62
35
TFB1MTFB1MQ8WVM0Q8WVM0rRNAmethylationrRNAmodificationtranscriptioninitiationatmitochondrialpromoter
Sorting nexin-17
3.6
56
80
✔
SNX17KRIT1Q15036O00522aortadevelopmentcardiacseptumdevelopmentcholesterolcatabolicprocesscoronaryvasculaturedevelopmentendocyticrecyclingendosomaltransportintracellularproteintransportkidneydevelopmentreceptor-mediatedendocytosisregulationofendocytosissignaltransductionangiogenesiscellredoxhomeostasisendotheliumdevelopmentintegrinactivationnegativeregulationofangiogenesisnegativeregulationofendothelialcellapoptoticprocessnegativeregulationofendothelialcellmigrationnegativeregulationofendothelialcellproliferationpositiveregulationofproteinbindingregulationofangiogenesisregulationofestablishmentofcellpolaritysmallGTPasemediatedsignaltransduction
DnaJ homolog subfamily C member 2
10.0
41
41
DNJC2DNJC2Q99543Q99543"denovocotranslationalproteinfolding"chromatinorganizationDNAreplicationnegativeregulationofDNAbiosyntheticprocesspositiveregulationofDNA-templatedtranscriptionregulationofcellularresponsetoheatregulationoftranslationalfidelity
Elongation factor Ts, mitochondrial
7.3
76
46
EFTSEFTSP43896P43896mitochondrialtranslationalelongationregulationofmitochondrialtranslationtranslationalelongation
Retinoic acid receptor RXR-gamma
10.0
67
29
RXRGRXRGP48443P48443anatomicalstructuredevelopmentcelldifferentiationheartdevelopmentneurondifferentiationperipheralnervoussystemdevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofmyelinationregulationoftranscriptionbyRNApolymeraseIIresponsetoretinoicacidretinoicacidreceptorsignalingpathwayskeletalmuscletissuedevelopment
Spectrin beta chain, non-erythrocytic 2
10.0
74
30
SPTN2SPTN2O15020O15020actincytoskeletonorganizationactinfilamentcappingadultbehaviorcerebellarPurkinjecelllayermorphogenesismulticellularorganismgrowthregulationofpostsynapticspecializationassemblysynapseassemblyvesicle-mediatedtransport
Nuclear pore complex protein Nup107
10.0
84
27
NU107NU107P57740P57740femalegonaddevelopmentmRNAexportfromnucleusnephrondevelopmentnuclearporecomplexassemblynucleocytoplasmictransportpost-transcriptionaltetheringofRNApolymeraseIIgeneDNAatnuclearperipheryproteinimportintonucleus
Proteasome subunit beta type-2
10.0
64
35
PSB2PSB2P49721P49721proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessresponsetoorganiccycliccompoundresponsetoorganonitrogencompound
Ribonuclease P protein subunit p20
7.5
55
55
✔
POP5POP7Q969H6O75817rRNAprocessing"tRNA5-leaderremoval"tRNAprocessingRNAphosphodiesterbondhydrolysisendonucleolytic
ADP-ribosylation factor 1
10.0
69
32
ARF1ARF1P84077P84077cellularcopperionhomeostasiscellularresponsetovirusdendriticspineorganizationintracellularproteintransportlong-termsynapticdepressionmitoticcleavagefurrowingressionregulationofArp2/3complex-mediatedactinnucleationregulationofreceptorinternalizationvesicle-mediatedtransport
S-arrestin
9.1
101
32
ARRSARRSP20443P20443Gprotein-coupledreceptorinternalizationsignaltransduction
Annexin A6
10.0
68
27
ANXA6ANXA6P08133P08133apoptoticsignalingpathwaygrowthplatecartilagechondrocytedifferentiationiontransmembranetransportmitochondrialcalciumionhomeostasisnegativeregulationofsequesteringofcalciumionneuralcrestcellmigrationplasmamembranerepairregulationofmusclecontraction
Claudin-3
2.0
56
84
CLD3CLD3Q9Z0G9Q9Z0G9actincytoskeletonreorganizationbicellulartightjunctionassemblycalcium-independentcell-celladhesionviaplasmamembranecell-adhesionmoleculescelladhesioncelljunctionmaintenanceepithelialcellmorphogenesisestablishmentofendothelialblood-brainbarriernegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofwoundhealingpositiveregulationofbicellulartightjunctionassemblypositiveregulationofcelljunctionassemblypositiveregulationofcellmigrationpositiveregulationofgeneexpressionpositiveregulationofmetallopeptidaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofwoundhealingregulationofcellmorphogenesisregulationofmembranepermeabilityregulationoftransepithelialtransportresponsetoethanolresponsetoGram-positivebacteriumresponsetohypoxia
Beta-3 adrenergic receptor
2.0
58
85
ADRB3ADRB3O02662O02662activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofMAPKcascade
Contactin-6
2.0
84
80
CNTN6CNTN6Q9JMB8Q9JMB8axonguidancedendriteself-avoidancehomophiliccelladhesionviaplasmamembraneadhesionmoleculesNotchsignalingpathwaypositiveregulationofNotchsignalingpathway
IGL@ protein
2.0
94
79
Q5FWF9Q5FWF9Q5FWF9Q5FWF9
Heparan sulfate glucosamine 3-O-sulfotransferase 1
2.0
62
81
HS3S1HS3S1O35310O35310glycosaminoglycanbiosyntheticprocessheparansulfateproteoglycanbiosyntheticprocess
Kin of IRRE-like protein 2
2.0
84
80
KIRR2KIRR2Q7TSU7Q7TSU7cell-celladhesionnegativeregulationofproteinphosphorylation
Prothrombin
2.0
nan
85
THRBTHRBP19221P19221acute-phaseresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidebloodcoagulationbloodcoagulationcommonpathwaycellsurfacereceptorsignalingpathwaycytolysisbyhostofsymbiontcellsfibrinolysisionchannelmodulatingGprotein-coupledreceptorsignalingpathwayligand-gatedionchannelsignalingpathwaynegativeregulationofastrocytedifferentiationnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofproteolysisneutrophil-mediatedkillingofgram-negativebacteriumplateletactivationpositiveregulationofbloodcoagulationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofinsulinsecretionpositiveregulationoflipidkinaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreleaseofsequesteredcalciumionintocytosolproteolysisregulationofcellshaperegulationofcytosoliccalciumionconcentrationregulationofgeneexpressionresponsetowoundingthrombin-activatedreceptorsignalingpathwayzymogenactivation
E3 ubiquitin-protein ligase RNF213
3.7
41
90
RN213RN213E9Q555E9Q555angiogenesisdefenseresponsetobacteriumimmunesystemprocesslipiddropletformationlipidubiquitinationnegativeregulationofnon-canonicalWntsignalingpathwayproteinautoubiquitinationproteinK63-linkedubiquitinationproteinubiquitinationregulationoflipidmetabolicprocesssproutingangiogenesisubiquitin-dependentproteincatabolicprocessxenophagy
IGL c2062_light_IGKV4-1_IGKJ5
2.0
88
80
A0A5C2G3X0A0A5C2G3X0A0A5C2G3X0A0A5C2G3X0
Glycerophosphocholine cholinephosphodiesterase ENPP6
2.0
67
84
ENPP6ENPP6Q8BGN3Q8BGN3cholinemetabolicprocesslipidcatabolicprocesslipidmetabolicprocess
ADP-dependent glucokinase
2.0
60
85
ADPGKADPGKQ8VDL4Q8VDL4carbohydratemetabolicprocessglucosemetabolicprocessglycolyticprocess
Fc gamma receptor IIIa
2.0
77
85
H0Y755H0Y755H0Y755H0Y755
Chymotrypsin-like elastase family member 1
3.0
73
79
CELA1CELA1P00772P00772proteolysis
Colipase
2.0
66
86
COLCOLP02703P02703digestionlipidcatabolicprocessresponsetobacteriumresponsetofood
Cytochrome c oxidase subunit 5B, mitochondrial
3.2
50
84
COX5BCOX5BP00428P00428mitochondrialelectrontransportcytochromectooxygen
Rho guanine nucleotide exchange factor TIAM2
4.0
71
71
TIAM2TIAM2Q6ZPF3Q6ZPF3activationofGTPaseactivitypositiveregulationofaxonogenesissmallGTPasemediatedsignaltransduction
Rho guanine nucleotide exchange factor 16
4.3
73
66
ARHGGARHGGQ3U5C8Q3U5C8activationofGTPaseactivitycellchemotaxispositiveregulationofproteinlocalizationtoplasmamembrane
Coronin-1A
4.4
93
65
COR1ACOR1AO89053O89053actincytoskeletonorganizationactinfilamentorganizationcalciumiontransportcellmigrationcell-substrateadhesioncellularresponsetointerleukin-4earlyendosometorecyclingendosometransportepithelialcellmigrationestablishmentoflocalizationincellhomeostasisofnumberofcellswithinatissueleukocytechemotaxisnaturalkillercelldegranulationnegativeregulationofactinnucleationnegativeregulationofneuronapoptoticprocessnegativeregulationofvesiclefusionnervegrowthfactorsignalingpathwayneuronapoptoticprocessphagocytosisphagolysosomeassemblypositivechemotaxispositiveregulationofTcellactivationpositiveregulationofTcellmigrationpositiveregulationofTcellproliferationregulationofactincytoskeletonorganizationregulationofactinfilamentpolymerizationregulationofactinpolymerizationordepolymerizationregulationofcellshaperegulationofreleaseofsequesteredcalciumionintocytosolresponsetocytokineTcellactivationTcellhomeostasisTcellmigrationTcellproliferationthymocytemigrationuropodorganizationvesiclefusion
Resistin-like beta
3.0
nan
88
RETNBRETNBQ99P86Q99P86responsetobacterium
Retinoschisin
2.0
nan
94
XLRS1XLRS1O15537O15537adaptationofrhodopsinmediatedsignalingcelladhesioneyedevelopmentproteinhomooligomerizationretinalayerformationvisualperception
5-hydroxytryptamine receptor 1E
2.0
44
86
5HT1E5HT1EP28566P28566adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-inhibitingserotoninreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessenger
RNA polymerase II elongation factor ELL2
6.0
nan
66
ELL2ELL2O00472O00472positiveregulationoftranscriptionelongationbyRNApolymeraseIIsnRNAtranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoter
Protein N-terminal glutamine amidohydrolase
7.7
62
48
NTAQ1NTAQ1Q96HA8Q96HA8proteinmodificationprocess
L-lactate dehydrogenase B chain
7.7
79
41
LDHBLDHBP00336P00336carboxylicacidmetabolicprocess
Adhesion G-protein coupled receptor G2
2.2
78
83
AGRG2AGRG2Q8CJ12Q8CJ12adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathway
Ubl carboxyl-terminal hydrolase 18
3.9
55
89
UBP18UBP18Q9WTV6Q9WTV6negativeregulationoftypeIinterferon-mediatedsignalingpathwayproteindeubiquitinationregulationofinflammatoryresponseresponsetobacteriumresponsetostilbenoidubiquitin-dependentproteincatabolicprocess
Cytosolic 5'-nucleotidase 3A
8.5
57
48
5NT3A5NT3AQ9D020Q9D020adenosinemetabolicprocessCMPcatabolicprocessdCMPcatabolicprocessdefenseresponsetovirusdTMPcatabolicprocessdUMPcatabolicprocessUMPcatabolicprocess
Lysophospholipase-like protein 1
9.0
80
31
LYPL1LYPL1Q5VWZ2Q5VWZ2proteindepalmitoylation
Myosin-4
9.5
53
42
MYH4MYL11Q5SX39P97457musclecontractionresponsetoactivityimmuneresponseskeletalmuscletissuedevelopment
Voltage-dependent calcium channel gamma-1 subunit
2.0
47
85
CCG1CCG1P19518P19518calciumiontransmembranetransportpositiveregulationofmusclecontractionregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannel
cAMP-dependent protein kinase type I-alpha regulatory subunit
2.0
63
85
✔
KAP0KAP0P00514P00514adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycardiacmusclecellproliferationmesodermformationnegativeregulationofactivatedTcellproliferationnegativeregulationofcAMP-dependentproteinkinaseactivitynegativeregulationofgeneexpressionpositiveregulationofinsulinsecretionsarcomereorganization
MHC class II antigen
2.0
78
80
D0AB36D0AB36D0AB36D0AB36adaptiveimmuneresponseantigenprocessingandpresentationofpeptideorpolysaccharideantigenviaMHCclassII
Interleukin-3
2.0
52
86
Q5SX77Q5SX77Q5SX77Q5SX77immuneresponse
Immunoglobulin lambda variable 2-8
2.0
92
79
LV208LV208P01709P01709adaptiveimmuneresponseimmuneresponse
C-type lectin domain family 2 member D
2.0
68
84
CLC2DCLC2DQ9UHP7Q9UHP7cellsurfacereceptorsignalingpathway
T-cell surface glycoprotein CD1c
2.1
72
83
CD1CCD1CP29017P29017adaptiveimmuneresponseantigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbpositiveregulationofTcellmediatedcytotoxicityTcellactivationinvolvedinimmuneresponse
Cadherin-2
2.0
28
88
CADH2CADH2P15116P15116bloodvesselmorphogenesisbraindevelopmentbrainmorphogenesiscalcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescelladhesioncellmigrationcell-celladhesioncell-celladhesionmediatedbycadherincell-celladhesionviaplasma-membraneadhesionmoleculescell-celljunctionassemblycerebralcortexdevelopmentglialcelldifferentiationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomeostasisofnumberofcellshomophiliccelladhesionviaplasmamembraneadhesionmoleculesmesenchymalcellmigrationmodulationofchemicalsynaptictransmissionnegativeregulationofcanonicalWntsignalingpathwayneuralcrestcelldevelopmentneuroepithelialcelldifferentiationneuroliginclusteringinvolvedinpostsynapticmembraneassemblyneuronalstemcellpopulationmaintenancepositiveregulationofMAPKcascadepositiveregulationofsynapticvesicleclusteringproteinlocalizationtoplasmamembraneradialglialcelldifferentiationregulationofaxonogenesisregulationofmyelinationregulationofoligodendrocyteprogenitorproliferationregulationofpostsynapticdensityprotein95clusteringregulationofproteinlocalizationregulationofRhoproteinsignaltransductionregulationofsynaptictransmissionglutamatergicstriatedmusclecelldifferentiationsynapseassemblysynapticvesicleclusteringtelencephalondevelopmenttypeBpancreaticcelldevelopment
MAb 6H10 light chain
2.0
nan
90
Q569X1A0A0U5BC76Q569X1A0A0U5BC76
Leukocyte-associated immunoglobulin-like receptor 1
2.0
86
81
LAIR1LAIR1Q6GTX8Q6GTX8adaptiveimmuneresponse
Prostaglandin E2 receptor EP3 subtype
2.0
70
84
PE2R3PE2R3P43115P43115adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycelldeathGprotein-coupledreceptorsignalingpathwayinflammatoryresponseintestinesmoothmusclecontractionnegativeregulationofgastricacidsecretionphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationoffevergeneration
CCN family member 3
2.0
31
90
CCN3CCN3Q9QZQ5Q9QZQ5angiogenesisboneregenerationcelladhesioncelladhesionmediatedbyintegrincellchemotaxischondrocytedifferentiationendothelialcellchemotaxisendothelialcell-celladhesionfibroblastmigrationhematopoieticstemcellhomeostasisnegativeregulationofcelldeathnegativeregulationofcellgrowthnegativeregulationofchondrocyteproliferationnegativeregulationofinflammatoryresponsenegativeregulationofinsulinsecretionnegativeregulationofmonocytechemotaxisnegativeregulationofmyotubedifferentiationnegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofsensoryperceptionofpainnegativeregulationofSMADproteinsignaltransductionpositiveregulationofNotchsignalingpathwayregulationofgeneexpressionsignaltransductionsmoothmusclecellmigrationsmoothmusclecellproliferationtypeBpancreaticcellproliferation
Contactin-5
2.0
77
82
CNTN5CNTN5P68500P68500axonguidancedendriteself-avoidancehomophiliccelladhesionviaplasmamembraneadhesionmoleculespresynapseassemblysensoryperceptionofsound
Protein CREG1
2.0
60
86
CREG1CREG1O75629O75629regulationoftranscriptionbyRNApolymeraseII
Carbonic anhydrase 7
2.0
43
82
CAH7CAH7P43166P43166neuroncellularhomeostasisone-carbonmetabolicprocesspositiveregulationofcellularpHreductionpositiveregulationofsynaptictransmissionGABAergicregulationofchloridetransportregulationofintracellularpH
T cell receptor gamma variable 8
2.0
81
81
TRGV8TRGV8A0A0C4DH27A0A0C4DH27adaptiveimmuneresponseinnateimmuneresponse
Putative phospholipase B-like 2
2.0
59
89
PLBL2PLBL2Q3TCN2Q3TCN2phospholipidcatabolicprocess
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
2.0
75
80
✔
PLCG2PLCG2Q8CIH5Q8CIH5activationofstore-operatedcalciumchannelactivityantifungalinnateimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwaycalcium-mediatedsignalingcellactivationcellularresponsetocalciumioncellularresponsetolectincellularresponsetolipidfollicularBcelldifferentiationinositoltrisphosphatebiosyntheticprocessintracellularsignaltransductionlipopolysaccharide-mediatedsignalingpathwaymacrophageactivationinvolvedinimmuneresponsenegativeregulationofprogrammedcelldeathphosphatidylinositolbiosyntheticprocessphospholipidcatabolicprocesspositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellcycleG1/SphasetransitionpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticcellcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofepithelialcellmigrationpositiveregulationofgeneexpressionpositiveregulationofI-kappaBphosphorylationpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagecytokineproductionpositiveregulationofMAPKcascadepositiveregulationofneuroinflammatoryresponsepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNLRP3inflammasomecomplexassemblypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphagocytosisengulfmentpositiveregulationofreactiveoxygenspeciesbiosyntheticprocesspositiveregulationofreceptorinternalizationpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferonproductionprogrammedcelldeathregulationofcalcineurin-NFATsignalingcascaderegulationofgeneexpressionregulationofI-kappaBkinase/NF-kappaBsignalingregulationoflipidmetabolicprocessreleaseofsequesteredcalciumionintocytosolresponsetoATPresponsetoaxoninjuryresponsetolipopolysaccharideresponsetomagnesiumionresponsetoyeaststimulatoryC-typelectinreceptorsignalingpathwayTcellreceptorsignalingpathwaytoll-likereceptorsignalingpathway
Interleukin-15 receptor subunit alpha
2.0
58
87
I15RAI15RAQ13261Q13261interleukin-15-mediatedsignalingpathwaynaturalkillercelldifferentiationpositiveregulationofnaturalkillercelldifferentiationpositiveregulationofphagocytosis
IG c934_light_IGKV1-5_IGKJ1
2.0
88
79
A0A5C2GTV1A0A5C2GTV1A0A5C2GTV1A0A5C2GTV1
Ighg protein
2.0
85
80
Q4VBH1Q4VBH1Q4VBH1Q4VBH1
OX-2 membrane glycoprotein
2.0
83
80
OX2GOX2GO54901O54901cell-celladhesionheterotypiccell-celladhesionnegativeregulationofcellpopulationproliferationnegativeregulationofinterleukin-6productionnegativeregulationofmacrophageactivationnegativeregulationofmacrophagemigrationnegativeregulationofmatrixmetallopeptidasesecretionnegativeregulationofneuroinflammatoryresponsenegativeregulationofneurondeathnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofTcellmigrationpositiveregulationofarginaseactivitypositiveregulationofCREBtranscriptionfactoractivitypositiveregulationofprotein-glutaminegamma-glutamyltransferaseactivitypositiveregulationoftransforminggrowthfactorbetaproductionregulationofneuroinflammatoryresponse
Ig-like domain-containing protein
2.0
83
80
Q6N030Q6N030Q6N030Q6N030
Beta-1,3-N-acetylglucosaminyltransferase manic fringe
2.0
nan
88
MFNGMFNGO09008O09008blastocystformationmarginalzoneBcelldifferentiationpatternspecificationprocesspositiveregulationofNotchsignalingpathwaypositiveregulationofproteinbindingregulationofNotchsignalingpathway
Lamin-B1
2.1
44
86
LMNB1LMNB1P20700P20700heterochromatinformationnuclearenvelopeorganizationnuclearmigrationnuclearporelocalizationproteinlocalizationtonuclearenvelope
Ighg protein
2.1
82
81
Q569B4Q569B4Q569B4Q569B4
HCG40889, isoform CRA_b
2.0
59
84
A0A024R962A0A024R962A0A024R962A0A024R962
Endogenous retrovirus group S71 member 1 Env polyprotein
2.1
52
83
B3VQ66B3VQ66B3VQ66B3VQ66
Amyloid beta precursor like protein 2
2.1
nan
89
APLP2APLP2Q06481Q06481axonogenesiscentralnervoussystemdevelopmentGprotein-coupledreceptorsignalingpathwaynegativeregulationofpeptidaseactivity
MAP kinase-interacting serine/threonine-protein kinase 2
3.5
37
92
MKNK2MKNK2Q9HBH9Q9HBH9cellsurfacereceptorsignalingpathwaycellularresponsetoarsenic-containingsubstanceextrinsicapoptoticsignalingpathwayinabsenceofligandhemopoiesisintracellularsignaltransductionpeptidyl-serinephosphorylationproteinautophosphorylationproteinphosphorylationregulationoftranslation
PHD finger protein 7
4.0
45
89
PHF7PHF7Q9DAG9Q9DAG9
Chronophin
3.6
73
70
PLPPPLPPQ96GD0Q96GD0actinrodassemblycellularresponsetoATPdephosphorylationpositiveregulationofactinfilamentdepolymerizationproteindephosphorylationpyridoxalphosphatecatabolicprocessregulationofcytokinesisregulationofmitoticnucleardivision
Zinc finger and SCAN domain-containing protein 2
3.7
38
91
ZSCA2ZSCA2Q07230Q07230celldifferentiationregulationoftranscriptionbyRNApolymeraseIIspermatogenesis
Eukaryotic translation initiation factor 2 alpha kinase 3
3.7
71
75
A5D791A5D791A5D791A5D791angiogenesiscellularresponsetoaminoacidstarvationcellularresponsetocoldcellularresponsetoglucosestarvationeiF2alphaphosphorylationinresponsetoendoplasmicreticulumstressendocrinepancreasdevelopmentendoplasmicreticulumunfoldedproteinresponseERoverloadresponseossificationpositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationofvascularendothelialgrowthfactorproductionproteinautophosphorylationregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathway
Golgi reassembly-stacking protein 2
3.7
78
71
GORS2GO45Q99JX3Q8R2X8celldifferentiationestablishmentofproteinlocalizationtoplasmamembraneGolgiorganizationorganelleassemblyorganelleorganizationresponsetoendoplasmicreticulumstressspermatogenesisGolgitoplasmamembraneproteintransport
Endogenous retrovirus group K member 24 Gag polyprotein
4.0
58
77
GAK24GAK24P63145P63145viralprocess
N-acylglucosamine 2-epimerase
4.3
82
63
RENBPRENBPP17560P17560carbohydratemetabolicprocessN-acetylglucosaminemetabolicprocessN-acetylmannosaminemetabolicprocessN-acetylneuraminatecatabolicprocess
Rhodopsin kinase GRK1
4.4
72
69
GRK1GRK1P28327P28327proteinautophosphorylationproteinphosphorylationregulationofrhodopsinmediatedsignalingpathwayregulationofsignaltransductionsignaltransductionvisualperception
Flap endonuclease 1
5.6
100
42
✔
FEN1FEN1P39748P39748base-excisionrepairgap-fillingDNArepairDNAreplicationDNAreplicationremovalofRNAprimerdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationmemorynucleicacidphosphodiesterbondhydrolysispositiveregulationofsisterchromatidcohesiontelomeremaintenanceviasemi-conservativereplicationUVprotection
Squalene synthase
5.7
81
52
FDFTFDFTP37268P37268cholesterolbiosyntheticprocessfarnesyldiphosphatemetabolicprocesssteroidbiosyntheticprocess
Fructose-2,6-bisphosphatase TIGAR
5.7
64
64
✔
TIGARTIGARQ9NQ88Q9NQ88cardiacmusclecellapoptoticprocesscellularresponsetocobaltioncellularresponsetoDNAdamagestimuluscellularresponsetohypoxiafructose16-bisphosphatemetabolicprocessfructose26-bisphosphatemetabolicprocessglucosecatabolicprocesstolactateviapyruvateglycolyticprocessintestinalepithelialcelldevelopmentmitophagynegativeregulationofglucosecatabolicprocesstolactateviapyruvatenegativeregulationofglycolyticprocessnegativeregulationofmitophagynegativeregulationofneurondeathnegativeregulationofprogrammedcelldeathnegativeregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofcardiacmusclecellapoptoticprocesspositiveregulationofDNArepairpositiveregulationofhexokinaseactivityreactiveoxygenspeciesmetabolicprocessregulationofpentose-phosphateshuntregulationofresponsetoDNAdamagecheckpointsignalingresponsetogammaradiationresponsetoischemiaresponsetoxenobioticstimulus
tRNA-splicing endonuclease subunit Sen34
5.8
81
48
SEN34SEN34Q9BSV6Q9BSV6mRNAprocessingtRNA-typeintronsplicesiterecognitionandcleavage
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
2.0
57
88
ENPP1ENPP1P06802P06802"3-phosphoadenosine5-phosphosulfatemetabolicprocess"adiposetissuedevelopmentadultlocomotorybehavioradultwalkingbehavioragingaortadevelopmentapoptoticprocessinvolvedindevelopmentarterydevelopmentarticularcartilagedevelopmentATPmetabolicprocessaxonregenerationB-1Bcellhomeostasisbiomineraltissuedevelopmentbonedevelopmentbonegrowthbonemineralizationbonemineralizationinvolvedinbonematurationboneremodelingboneresorptionbonetrabeculaformationcalciumionhomeostasiscartilagedevelopmentcellmorphogenesisinvolvedindifferentiationcellpopulationproliferationcellularhomeostasiscellularphosphateionhomeostasiscellularresponsetoinsulinstimuluscellularresponsetosodiumphosphatecementummineralizationcentralnervoussystemmyelinationcollagen-activatedsignalingpathwaydefenseresponsetoprotozoandeterminationofadultlifespandiphosphatemetabolicprocessendochondralbonemorphogenesisendochondralossificationestablishmentoflocalizationincellfatcelldifferentiationfatpaddevelopmentfattyacidmetabolicprocessfibroblastgrowthfactorreceptorsignalingpathwaygeneexpressiongenerationofprecursormetabolitesandenergyglucosehomeostasisglucoseimportglycolyticprocessheartdevelopmenthematopoieticstemcellmigrationtobonemarrowhormonemetabolicprocessinflammatoryresponsetoantigenicstimulusinorganicdiphosphatetransportkidneydevelopmentleukocyteactivationinvolvedininflammatoryresponseligamentousossificationlong-termsynapticpotentiationmacrophagedifferentiationmagnesiumionhomeostasismelanocytedifferentiationmicrogliadifferentiationmicroglialcellmigrationmiddleearmorphogenesismitochondrionorganizationmorphogenesisofanepitheliummRNAtranscriptionbyRNApolymeraseIImucussecretionmulticellularorganismagingmulticellularorganismgrowthnegativeregulationofbonemineralizationnegativeregulationofcellgrowthnegativeregulationoffatcelldifferentiationnegativeregulationofglucoseimportnegativeregulationofglycogenbiosyntheticprocessnegativeregulationofhhtargettranscriptionfactoractivitynegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofossificationnegativeregulationofproteinautophosphorylationneuronapoptoticprocessnitrogencompoundmetabolicprocessnucleicacidphosphodiesterbondhydrolysisnucleosidetriphosphatecatabolicprocessodontogenesisoligodendrocyteapoptoticprocessorganicphosphonatemetabolicprocessossificationosteoblastdifferentiationosteoclastdifferentiationphosphateionhomeostasisphosphate-containingcompoundmetabolicprocessplasmacelldifferentiationpost-embryonicforelimbmorphogenesisproteinpoly-ADP-ribosylationregulationofbonemineralizationresponsetoATPresponsetodietaryexcessresponsetoGram-positivebacteriumresponsetoinorganicsubstanceresponsetoinsulinresponsetoL-ascorbicacidresponsetomagnesiumionresponsetoplatelet-derivedgrowthfactorresponsetosodiumphosphateresponsetovitaminB6responsetowoundingsensoryperceptionofmechanicalstimulussensoryperceptionofsoundsensoryperceptionoftemperaturestimulussequesteringoftriglycerideskindevelopmentsmoothenedsignalingpathwayspinalcorddevelopmentTcelldifferentiationtoothmineralizationvascularassociatedsmoothmusclecellmigrationvascularassociatedsmoothmusclecellproliferationvasculogenesisvitaminD3metabolicprocessWntsignalingpathway
Beta-crystallin B3
6.4
63
53
CRBB3CRBB3P26998P26998lensdevelopmentincamera-typeeyevisualperception
SKI8 subunit of superkiller complex protein
6.7
60
60
SKI8SKI8Q9GZS3Q9GZS3histoneH3-K4methylationhistoneH3-K4trimethylationnegativeregulationofmyeloidcelldifferentiationpositiveregulationofhistoneH3-K4methylationpositiveregulationofhistoneH3-K79methylationtranscriptionelongationbyRNApolymeraseIIpromoterWntsignalingpathway
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
5.3
69
53
GNAS2GNAS2P63092P63092activationofadenylatecyclaseactivityadenylatecyclase-activatingadrenergicreceptorsignalingpathwayadenylatecyclase-activatingdopaminereceptorsignalingpathwayadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaybonedevelopmentcellularresponsetocatecholaminestimuluscellularresponsetoprostaglandinEstimuluscognitiondevelopmentalgrowthhairfollicleplacodeformationintracellulartransportplateletaggregationpositiveregulationofcAMP-mediatedsignalingpositiveregulationofcold-inducedthermogenesispositiveregulationofGTPaseactivitysensoryperceptionofsmell
Gamma-glutamylcyclotransferase
7.0
61
52
GGCTGGCTO75223O75223releaseofcytochromecfrommitochondria
40S ribosomal protein SA
7.5
94
35
G1TWL4G1TWL4G1TWL4G1TWL4ribosomalsmallsubunitassemblytranslation
TAR DNA-binding protein 43
7.6
58
49
TADBPTADBPQ13148Q13148"3-UTR-mediatedmRNAdestabilization""3-UTR-mediatedmRNAstabilization"amyloidfibrilformationmRNAprocessingnegativeregulationbyhostofviraltranscriptionnegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationnuclearinnermembraneorganizationpositiveregulationofproteinimportintonucleusregulationofapoptoticprocessregulationofcellcycleregulationofcircadianrhythmregulationofgeneexpressionregulationofproteinstabilityrhythmicprocessRNAsplicing
NADH-ubiquinone oxidoreductase chain 6
7.9
94
38
A9UIY5NU4LMA9UIY5P03903aerobicrespirationATPsynthesiscoupledelectrontransportprotonmotiveforce-drivenmitochondrialATPsynthesis
Eukaryotic peptide chain release factor subunit 1
8.4
65
46
✔
ERF1ERF1P62495P62495cytoplasmictranslationalterminationnuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecayproteinmethylationregulationoftranslationalterminationtranslationaltermination
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
8.6
61
40
CP24ACP24AQ09128Q09128cellularresponsetovitaminDfattyacidomega-oxidationosteoblastdifferentiationresponsetovitaminDvitaminDcatabolicprocessvitaminDmetabolicprocess
Katanin p80 WD40 repeat-containing subunit B1
4.4
71
70
KTNB1KTNB1Q8BG40Q8BG40celldivisionmicrotubuledepolymerizationmicrotubuleseveringmitoticchromosomemovementtowardsspindlepolenegativeregulationofmicrotubuledepolymerizationpositiveregulationofcelldeathpositiveregulationofmicrotubuledepolymerizationpositiveregulationofneuronprojectiondevelopment
Inositol oxygenase
2.0
nan
89
MIOXMIOXQ9UGB7Q9UGB7inositolcatabolicprocess
Amyloid-beta A4 precursor protein-binding family B member 3
8.7
nan
48
APBB3APBB3O95704O95704positiveregulationofproteinsecretionregulationofDNA-templatedtranscription
BMAL1b
3.2
59
77
Q6F6D6Q6F6D6Q6F6D6Q6F6D6positiveregulationofDNA-templatedtranscription
Neutrophil defensin 3
4.4
70
72
DEF3DEF3P59666P59666antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdefenseresponsetovirusinnateimmuneresponseinmucosaintracellularestrogenreceptorsignalingpathwaykillingofcellsofanotherorganism
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
8.8
71
39
PDE6APDE6AP11541P11541signaltransductionvisualperception
Bcl-2-like protein 15
9.0
35
49
B2L15B2L15Q5TBC7Q5TBC7apoptoticprocessregulationofapoptoticprocess
RNA-binding motif protein, X-linked 2
9.3
81
32
RBMX2RBMX2Q9Y388Q9Y388mRNAsplicingviaspliceosomeU2-typeprespliceosomeassembly
Ornithine decarboxylase antizyme 1
9.5
71
31
OAZ1OAZ1P54368P54368negativeregulationofpolyaminetransmembranetransportpolyaminebiosyntheticprocesspositiveregulationofintracellularproteintransportpositiveregulationofproteincatabolicprocessregulationofcatalyticactivity
Galectin-16
9.5
50
40
LEG16LEG16A8MUM7A8MUM7apoptoticprocesspositiveregulationofTcellapoptoticprocess
Nuclear cap-binding protein subunit 1
9.5
74
34
NCBP1NCBP1Q09161Q091617-methylguanosinemRNAcappingalternativemRNAsplicingviaspliceosomecap-dependenttranslationalinitiationdefenseresponsetovirushistonemRNAmetabolicprocessmiRNA-mediatedgenesilencing"mRNA3-endprocessing"mRNAexportfromnucleusmRNAsplicingviaspliceosomemRNAtranscriptionbyRNApolymeraseIInuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaypositiveregulationofcellgrowth"positiveregulationofmRNA3-endprocessing"positiveregulationofmRNAsplicingviaspliceosomepositiveregulationofphosphorylationofRNApolymeraseIIC-terminaldomainpositiveregulationofRNAbindingpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpre-mRNAcleavagerequiredforpolyadenylationprimarymiRNAprocessingregulationofmRNAprocessingregulationoftranslationalinitiationRNAcatabolicprocessRNAsplicingsnRNAexportfromnucleusspliceosomalcomplexassembly
RAC-alpha serine/threonine-protein kinase
6.8
58
56
AKT1AKT1P31749P31749activation-inducedcelldeathofTcellsanoikisapoptoticmitochondrialchangesbehavioralresponsetopaincarbohydratetransportcelldifferentiationcellmigrationinvolvedinsproutingangiogenesiscellpopulationproliferationcellularresponsetocadmiumioncellularresponsetodecreasedoxygenlevelscellularresponsetoepidermalgrowthfactorstimuluscellularresponsetogranulocytemacrophagecolony-stimulatingfactorstimuluscellularresponsetoinsulinstimuluscellularresponsetonervegrowthfactorstimuluscellularresponsetooxidisedlow-densitylipoproteinparticlestimuluscellularresponsetoprostaglandinEstimuluscellularresponsetoreactiveoxygenspeciescellularresponsetotumornecrosisfactorcellularresponsetovascularendothelialgrowthfactorstimuluscytokine-mediatedsignalingpathwayepidermalgrowthfactorreceptorsignalingpathwayestablishmentofproteinlocalizationtomitochondrionexcitatorypostsynapticpotentialexecutionphaseofapoptosisfibroblastmigrationGprotein-coupledreceptorsignalingpathwaygeneexpressiongermcelldevelopmentglucosehomeostasisglucosemetabolicprocessglycogenbiosyntheticprocessglycogencelldifferentiationinvolvedinembryonicplacentadevelopmentI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseinsulinreceptorsignalingpathwayinsulin-likegrowthfactorreceptorsignalingpathwayinterleukin-18-mediatedsignalingpathwayintracellularsignaltransductionlabyrinthinelayerbloodvesseldevelopmentlipopolysaccharide-mediatedsignalingpathwaymaintenanceofproteinlocationinmitochondrionmammaryglandepithelialcelldifferentiationmaternalplacentadevelopmentnegativeregulationofapoptoticprocessnegativeregulationofautophagynegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofendopeptidaseactivitynegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationoffattyacidbeta-oxidationnegativeregulationofgeneexpressionnegativeregulationofleukocytecell-celladhesionnegativeregulationoflong-chainfattyacidimportacrossplasmamembranenegativeregulationoflymphocytemigrationnegativeregulationofmacroautophagynegativeregulationofneurondeathnegativeregulationofNotchsignalingpathwaynegativeregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaynegativeregulationofproteinbindingnegativeregulationofproteinkinaseactivitynegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofproteinubiquitinationnegativeregulationofproteolysisnegativeregulationofreleaseofcytochromecfrommitochondriaNIK/NF-kappaBsignalingnitricoxidebiosyntheticprocessosteoblastdifferentiationpeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationperipheralnervoussystemmyelinmaintenancephosphatidylinositol3-kinasesignalingphosphorylationpositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofendodeoxyribonucleaseactivitypositiveregulationofendothelialcellmigrationpositiveregulationofendothelialcellproliferationpositiveregulationoffatcelldifferentiationpositiveregulationoffibroblastmigrationpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglucosemetabolicprocesspositiveregulationofglycogenbiosyntheticprocesspositiveregulationofI-kappaBphosphorylationpositiveregulationoflipidbiosyntheticprocesspositiveregulationofmitochondrialmembranepotentialpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationoforgangrowthpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinlocalizationtocellsurfacepositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinmetabolicprocesspositiveregulationofproteinphosphorylationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsodiumiontransportpositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautophosphorylationproteinimportintonucleusproteinkinaseBsignalingproteinphosphorylationproteinubiquitinationregulationofapoptoticprocessregulationofcellmigrationregulationofglycogenbiosyntheticprocessregulationofmRNAstabilityregulationofmyelinationregulationofneuronprojectiondevelopmentregulationofpostsynapseorganizationregulationofsignaltransductionbyp53classmediatorregulationoftranslationregulationoftypeBpancreaticcelldevelopmentresponsetofluidshearstressresponsetofoodresponsetogrowthfactorresponsetogrowthhormoneresponsetoheatresponsetoinsulin-likegrowthfactorstimulusresponsetooxidativestressresponsetoUV-Asignaltransductionsphingosine-1-phosphatereceptorsignalingpathwaystriatedmusclecelldifferentiationTcellcostimulationTORsignaling
Host cell factor 2
9.8
52
40
HCFC2HCFC2Q9D968Q9D968chromatinremodelingnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscription
Calcium-binding protein 39
9.8
65
36
CAB39CAB39Q9Y376Q9Y376activationofproteinkinaseactivitycellularhypotonicresponseintracellularsignaltransductionnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransporteractivitypeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofproteinserine/threoninekinaseactivityresponsetoactivityresponsetothyroidhormonesignaltransduction
Far upstream element-binding protein 1
9.9
nan
39
FUBP1FUBP1Q96AE4Q96AE4positiveregulationofgeneexpressionregulationofgeneexpression
Glucose-6-phosphate isomerase
9.9
73
25
G6PIG6PIP06744P06744carbohydratemetabolicprocesserythrocytehomeostasisgluconeogenesisglucose6-phosphatemetabolicprocessglucosehomeostasisglycolyticprocesshemostasishumoralimmuneresponseinuteroembryonicdevelopmentlearningormemorymesodermformationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofneuronapoptoticprocesspositiveregulationofendothelialcellmigrationpositiveregulationofimmunoglobulinproductionresponsetocadmiumionresponsetoestradiolresponsetoimmobilizationstressresponsetomorphineresponsetomusclestretchresponsetoprogesteroneresponsetotestosterone
Pterin-mimicking anti-idiotope kappa chain variable region
2.0
91
80
Q920E6Q920E6Q920E6Q920E6
Immunoglobulin kappa variable 1D-33
2.0
86
81
KVD33KVD33P01593P01593adaptiveimmuneresponseimmuneresponse
Hemopexin
2.0
nan
90
HEMOHEMOP20058P20058cellularironionhomeostasis
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
2.0
60
85
NDUS5NDUS5Q02379Q02379mitochondrialrespiratorychaincomplexIassembly
Zinc finger protein 568
3.6
37
93
ZN568ZN568E9PYI1E9PYI1convergentextensioninvolvedinaxiselongationconvergentextensioninvolvedinneuralplateelongationembryonicplacentamorphogenesisinuteroembryonicdevelopmentnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofcellcommunicationregulationoftranscriptionbyRNApolymeraseII
Folliculin-interacting protein 1
4.0
62
88
FNIP1FNIP1Q68FD7Q68FD7BcellapoptoticprocessBcelldifferentiationcellularresponsetostarvationimmatureBcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofTORsignalingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofBcellapoptoticprocesspositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofproteinphosphorylationpositiveregulationofprotein-containingcomplexassemblypositiveregulationofTORsignalingregulationofpro-BcelldifferentiationregulationofproteinphosphorylationTORsignaling
Orexin/Hypocretin receptor type 1
2.0
63
86
OX1ROX1RO43613O43613chemicalsynaptictransmissionfeedingbehaviorGprotein-coupledreceptorsignalingpathwayneuropeptidesignalingpathwaypositiveregulationofERK1andERK2cascaderegulationofcytosoliccalciumionconcentration
39S ribosomal protein L38, mitochondrial
7.9
48
56
✔
RM38RM38Q96DV4Q96DV4mitochondrialtranslation
Kinesin-like protein KIF15
7.4
59
54
✔
KIF15KIF15Q9NS87Q9NS87microtubule-basedmovementmitoticcellcycleregulationofmitoticspindleassembly
Cytochrome P450 4B1
3.4
80
71
CP4B1CP4B1P15128P15128
Uncharacterized protein
9.8
77
37
E9M5R0CCL3E9M5R0P10855astrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponseleukocytechemotaxislipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofosteoclastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingproteinphosphorylationregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstanceresponsetoxenobioticstimulussignalingTcellchemotaxis
L-lactate dehydrogenase C chain
5.7
66
54
LDHCLDHCP00342P00342ATPbiosyntheticprocessflagellatedspermmotilitylactatebiosyntheticprocessfrompyruvatelactateoxidationpyruvatecatabolicprocesspyruvatemetabolicprocess
Calcium uptake protein 2, mitochondrial
2.0
52
85
MICU2MICU1Q8IYU8Q9BPX6calciumimportintothemitochondrionmitochondrialcalciumionhomeostasismitochondrialcalciumiontransmembranetransportnegativeregulationofmitochondrialcalciumionconcentrationpositiveregulationofmitochondrialcalciumionconcentrationcalciumionimportdefenseresponseproteinhomooligomerizationregulationofcellularhyperosmoticsalinityresponse
T cell receptor beta variable 28
2.0
88
80
TVB28TVB28A0A5B6A0A5B6adaptiveimmuneresponsecellsurfacereceptorsignalingpathway
Cytotoxic Tcell receptor
2.0
86
81
A2NTU7A2NTU7A2NTU7A2NTU7
T cell receptor beta variable 9
2.0
86
81
TVB9TVB9A0A0B4J1U6A0A0B4J1U6adaptiveimmuneresponsecellsurfacereceptorsignalingpathway
TRADV16D
2.0
83
81
Q5R1F1Q5R1F1Q5R1F1Q5R1F1
Odorant-binding protein 2a
2.0
45
87
OBP2AOBP2AQ9NY56Q9NY56glucosehomeostasisresponsetostimulussensoryperceptionofchemicalstimulussensoryperceptionofsmell
Butyrophilin-like protein 2
2.0
80
81
BTNL2BTNL2O70355O70355negativeregulationofTcellreceptorsignalingpathwaypositiveregulationofinterleukin-2productionpositiveregulationofTcellproliferationregulationofcytokineproductionTcellreceptorsignalingpathway
LOC367586 protein
2.1
84
80
Q5BJZ2Q5BJZ2Q5BJZ2Q5BJZ2
TRAV6D-7
2.0
82
80
Q5R1F5Q5R1F5Q5R1F5Q5R1F5
Protein O-mannose kinase
2.0
nan
91
SG196SG196Q3TUA9Q3TUA9braindevelopmentcarbohydratephosphorylationlearningormemoryneuromuscularprocessproteinO-linkedglycosylationproteinphosphorylationsensoryperceptionofpain
Wnt inhibitory factor 1
2.0
70
88
WIF1WIF1Q9Y5W5Q9Y5W5anatomicalstructuredevelopmentnegativeregulationofWntsignalingpathwaypositiveregulationoffatcelldifferentiationsignaltransductionWntsignalingpathway
Kit ligand
2.0
nan
89
SCFSCFP21583P21583celladhesionectopicgermcellprogrammedcelldeathembryonichemopoiesisextrinsicapoptoticsignalingpathwayinabsenceofligandhematopoieticprogenitorcelldifferentiationmalegonaddevelopmentmastcellapoptoticprocessmastcellmigrationmastcellproliferationmelanocytemigrationmyeloidleukocytedifferentiationnegativeregulationofmastcellapoptoticprocessneuralcrestcellmigrationovarianfollicledevelopmentpeptidyl-tyrosinephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofhematopoieticprogenitorcelldifferentiationpositiveregulationofhematopoieticstemcellproliferationpositiveregulationofleukocytemigrationpositiveregulationofMAPkinaseactivitypositiveregulationofmastcellproliferationpositiveregulationofmelanocytedifferentiationpositiveregulationofmyeloidleukocytedifferentiationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofRasproteinsignaltransductionpositiveregulationofTcellproliferationRasproteinsignaltransductionresponsetoorganiccycliccompoundTcellproliferation
VPS10 domain-containing receptor SorCS2
2.0
nan
89
SORC2SORC2Q9EPR5Q9EPR5intracellularproteintransportlong-termsynapticdepression
Potassium-transporting ATPase subunit beta
2.0
56
87
ATP4BATP4BP18434P18434celladhesioncellularpotassiumionhomeostasiscellularsodiumionhomeostasispotassiumionimportacrossplasmamembraneprotontransmembranetransportsodiumionexportacrossplasmamembrane
TRAV14-3
2.0
84
80
Q5R1B3Q5R1B3Q5R1B3Q5R1B3
Cytochrome c oxidase subunit 6B1
2.0
53
85
✔
CX6B1CX6B1P56391P56391oxidativephosphorylation
T cell receptor alpha variable 4
2.0
79
82
TVA4TVA4A0A0B4J268A0A0B4J268adaptiveimmuneresponseresponsetobacterium
Allergen Can f 4
2.0
46
88
J9P950J9P950J9P950J9P950
Uncharacterized protein DKFZp686I04196
2.0
84
80
Q6N093Q6N093Q6N093Q6N093
Butyrophilin subfamily 1 member A1
2.1
79
81
BT1A1BT1A1P18892P18892regulationofcytokineproductionTcellreceptorsignalingpathway
Single-chain Fv
2.1
85
80
Q65ZC9Q65ZC9Q65ZC9Q65ZC9
Vesicular integral-membrane protein VIP36
2.1
59
82
✔
LMAN2LMAN2P49256P49256endoplasmicreticulumtoGolgivesicle-mediatedtransportpositiveregulationofphagocytosisproteintransportretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulum
CD276 antigen
2.1
56
85
CD276CD276Q8VE98Q8VE98negativeregulationofinflammatoryresponsenegativeregulationofinterleukin-2productionnegativeregulationofTcellproliferationnegativeregulationoftypeIIinterferonproductionpositiveregulationofbonemineralizationpositiveregulationofinterleukin-2productionpositiveregulationofosteoblastdifferentiationpositiveregulationofTcellproliferationpositiveregulationoftypeIIinterferonproductionregulationofcytokineproductionregulationofimmuneresponseTcellactivationTcellproliferationTcellreceptorsignalingpathway
Sushi domain-containing protein 2
2.0
55
87
SUSD2SUSD2Q9DBX3Q9DBX3negativeregulationofcellcycleG1/Sphasetransitionnegativeregulationofcelldivision
Igk protein
2.1
96
79
Q52L95Q52L95Q52L95Q52L95
Ectonucleoside triphosphate diphosphohydrolase 2
2.0
45
89
ENTP2ENTP2O35795O35795cellularresponsetointerferon-alphacellularresponsetointerleukin-6cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactorGprotein-coupledreceptorsignalingpathwaynucleosidediphosphatecatabolicprocessplateletactivationpurineribonucleosidediphosphatecatabolicprocessresponsetoauditorystimulus
Apolipoprotein D
2.0
56
85
APODAPODP05090P05090agingangiogenesisbraindevelopmentglucosemetabolicprocesslipidmetabolicprocessnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationoffocaladhesionassemblynegativeregulationoflipoproteinlipidoxidationnegativeregulationofmonocytechemotacticprotein-1productionnegativeregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaynegativeregulationofproteinimportintonucleusnegativeregulationofsmoothmusclecellproliferationnegativeregulationofsmoothmusclecell-matrixadhesionnegativeregulationofTcellmigrationperipheralnervoussystemaxonregenerationresponsetoaxoninjuryresponsetoreactiveoxygenspeciestissueregeneration
Rieske domain-containing protein
3.8
76
77
RFESDRFESDQ8K2P6Q8K2P6
Transcription factor E2F1
4.4
62
73
E2F1E2F1Q01094Q01094anoikiscellularresponsetofattyacidcellularresponsetohypoxiacellularresponsetonervegrowthfactorstimuluscellularresponsetoxenobioticstimulusDNAdamagecheckpointsignalingDNA-templatedtranscriptionforebraindevelopmentG1/Stransitionofmitoticcellcycleintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagelensfibercellapoptoticprocessmRNAstabilizationnegativeregulationofDNAbindingnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationoffatcelldifferentiationnegativeregulationoffatcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptioninvolvedinG1/StransitionofmitoticcellcyclepositiveregulationofapoptoticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationoffibroblastproliferationpositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationofG1/StransitionofmitoticcellcycleregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptioninvolvedinG1/Stransitionofmitoticcellcyclespermatogenesis
Sorting nexin-9
5.1
nan
66
SNX9SNX9Q9Y5X1Q9Y5X1cleavagefurrowformationendocytosisendosomaltransportintracellularproteintransportlipidtubeassemblymitoticcytokinesisplasmamembranetubulationpositiveregulationofactinfilamentpolymerizationpositiveregulationofGTPaseactivitypositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofproteinkinaseactivityprotein-containingcomplexassemblyreceptor-mediatedendocytosis
Mediator of RNA polymerase II transcription subunit 30
5.3
66
60
MED30MED30Q96HR3Q96HR3positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblysomaticstemcellpopulationmaintenance
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
3.3
70
74
NDUB7NDUB7Q02368Q02368mitochondrialrespiratorychaincomplexIassembly
Golgi reassembly-stacking protein 1
7.9
56
47
✔
GORS1GOGA2Q9BQQ3Q08379establishmentofproteinlocalizationtoplasmamembraneGolgiorganizationnegativeregulationofdendritemorphogenesisproteinN-linkedglycosylationproteintransportasymmetriccelldivisioncentrosomecycleendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgidisassemblyGolgiribbonformationmeioticspindleassemblymicrotubulenucleationmitoticspindleassemblynegativeregulationofautophagynegativeregulationofproteinbindingpositiveregulationofproteinglycosylationproteinglycosylationproteinhomotetramerizationspindleassembly
RNA-binding protein Musashi homolog 1
7.9
66
54
MSI1HMSI1HQ61474Q61474centralnervoussystemdevelopmentepithelialcelldifferentiationregulationoftranslationresponsetohormone
Galectin
8.4
53
48
A0A2K6TQH4A0A2K6TQH4A0A2K6TQH4A0A2K6TQH4
Protein S100-A14
8.6
20
56
S10AES10AEQ9HCY8Q9HCY8apoptoticprocesscalciumionhomeostasisdefenseresponsetobacteriumpositiveregulationofgranulocytechemotaxispositiveregulationofmonocytechemotaxisresponsetolipopolysaccharidetoll-likereceptor4signalingpathway
Cyclin-D-binding Myb-like transcription factor 1
9.0
30
51
DMTF1DMTF1Q9Y222Q9Y222cellcycleregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Protein lin-28 homolog B
9.3
75
40
LN28BLN28BQ6ZN17Q6ZN17miRNAcatabolicprocessnegativeregulationofpre-miRNAprocessingnegativeregulationofprimarymiRNAprocessingpositiveregulationofmiRNAcatabolicprocesspre-miRNAprocessing"RNA3-endprocessing"RNAdestabilization
Probable ATP-dependent RNA helicase DDX53
9.4
73
37
DDX53DDX53Q86TM3Q86TM3
ATP-binding cassette sub-family D member 1
9.6
51
41
ABCD1ABCD1P33897P33897alpha-linolenicacidmetabolicprocessfattyacidbeta-oxidationfattyacidelongationfattyacidhomeostasislinoleicacidmetabolicprocesslong-chainfattyacidcatabolicprocesslong-chainfattyacidimportintoperoxisomemyelinmaintenancenegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofreactiveoxygenspeciesbiosyntheticprocessneuronprojectionmaintenanceperoxisomalmembranetransportperoxisomeorganizationpositiveregulationoffattyacidbeta-oxidationpositiveregulationofunsaturatedfattyacidbiosyntheticprocessregulationofcellularresponsetooxidativestressregulationoffattyacidbeta-oxidationregulationofmitochondrialdepolarizationregulationofoxidativephosphorylationsterolhomeostasisverylong-chainfattyacidcatabolicprocessverylong-chainfattyacidmetabolicprocessverylong-chainfatty-acyl-CoAcatabolicprocess
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
9.7
74
29
PDE4BPDE4BQ07343Q07343cAMPcatabolicprocesscellularresponsetoepinephrinestimuluscellularresponsetolipopolysaccharidecellularresponsetoxenobioticstimulusleukocytemigrationnegativeregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessnegativeregulationofrelaxationofcardiacmuscleneutrophilchemotaxisneutrophilhomeostasispositiveregulationofinterleukin-2productionpositiveregulationoftypeIIinterferonproductionregulationofcardiacmusclecellcontractionregulationofhighvoltage-gatedcalciumchannelactivitysignaltransductionTcellreceptorsignalingpathway
39S ribosomal protein L53, mitochondrial
9.8
61
34
✔
RM53RM53Q96EL3Q96EL3mitochondrialtranslation
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial
10.0
101
19
ODBAODBAP12694P12694branched-chainaminoacidcatabolicprocess
T cell receptor alpha variable 12-2
2.0
85
78
TVAL2TVAL2A0A075B6T6A0A075B6T6adaptiveimmuneresponse
Lysosomal alpha-mannosidase
2.0
66
82
MA2B1MA2B1Q29451Q29451learningormemorymannosemetabolicprocessoligosaccharidecatabolicprocessproteinmodificationprocess
BRE
2.2
90
79
A2NI60A2NI60A2NI60A2NI60
G-protein coupled bile acid receptor 1
3.6
55
82
GPBARGPBARQ8TDU6Q8TDU6cellsurfacebileacidreceptorsignalingpathwaycellularresponsetobileacidGprotein-coupledreceptorsignalingpathwaypositiveregulationofcholangiocyteproliferationpositiveregulationofERK1andERK2cascaderegulationofbicellulartightjunctionassembly
Wee1-like protein kinase 2
3.6
59
83
WEE2WEE2P0C1S8P0C1S8femalemeioticnucleardivisionfemalepronucleusassemblymitoticcellcyclenegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofoocytematurationpositiveregulationofphosphorylationregulationoffertilizationregulationofmeiosisI
Cytokine receptor-like factor 3
4.0
62
74
CRLF3CRLF3Q9Z2L7Q9Z2L7negativeregulationofcellgrowthnegativeregulationofG1/StransitionofmitoticcellcyclepositiveregulationofDNA-templatedtranscriptionpositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationoftranscriptionbyRNApolymeraseII
Eukaryotic translation initiation factor 2-alpha kinase 3
4.8
67
69
E2AK3E2AK3Q9NZJ5Q9NZJ5activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessangiogenesisbonemineralizationcalcium-mediatedsignalingcellularresponsetoaminoacidstarvationcellularresponsetocoldcellularresponsetoglucosestarvationchondrocytedevelopmenteiF2alphaphosphorylationinresponsetoendoplasmicreticulumstressendocrinepancreasdevelopmentendoplasmicreticulumorganizationendoplasmicreticulumunfoldedproteinresponseERoverloadresponseinsulin-likegrowthfactorreceptorsignalingpathwaynegativeregulationofmyelinationnegativeregulationoftranslationnegativeregulationoftranslationinresponsetostressnegativeregulationoftranslationalinitiationinresponsetostressossificationpeptidyl-serinephosphorylationPERK-mediatedunfoldedproteinresponsepositiveregulationofgeneexpressionpositiveregulationofproteinlocalizationtonucleuspositiveregulationoftranscriptionbyRNApolymeraseIpositiveregulationofvascularendothelialgrowthfactorproductionproteinautophosphorylationproteinphosphorylationregulationofendoplasmicreticulumstress-inducedeIF2alphaphosphorylationregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwayregulationoftranslationalinitiationbyeIF2alphaphosphorylationresponsetoendoplasmicreticulumstressresponsetomanganese-inducedendoplasmicreticulumstressskeletalsystemdevelopment
Calcium uptake protein 1, mitochondrial
2.0
52
85
MICU2MICU1Q8IYU8Q9BPX6calciumimportintothemitochondrionmitochondrialcalciumionhomeostasismitochondrialcalciumiontransmembranetransportnegativeregulationofmitochondrialcalciumionconcentrationpositiveregulationofmitochondrialcalciumionconcentrationcalciumionimportdefenseresponseproteinhomooligomerizationregulationofcellularhyperosmoticsalinityresponse
Glycylpeptide N-tetradecanoyltransferase 1
10.0
77
29
NMT1AIFM3P30419Q96NN9cellularketonemetabolicprocessinuteroembryonicdevelopmentN-terminalpeptidyl-glycineN-myristoylationN-terminalproteinmyristoylationpositiveregulationofproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwayregulationofrhodopsinmediatedsignalingpathwayexecutionphaseofapoptosis
Interleukin-2
2.0
55
86
Q6QWN0Q6QWN0Q6QWN0Q6QWN0adaptiveimmuneresponse
T cell receptor beta variable 6-5
2.0
85
81
TVB65TVB65A0A0K0K1A5A0A0K0K1A5adaptiveimmuneresponsecellsurfacereceptorsignalingpathway
Immunoglobulin heavy variable 1-69D
2.0
87
79
HV69DHV69DA0A0B4J2H0A0A0B4J2H0BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
V-alpha FR1
2.0
84
81
A2NVQ1A2NVQ1A2NVQ1A2NVQ1
Anti-myosin immunoglobulin heavy chain variable region
2.0
82
80
Q9JL75Q9JL75Q9JL75Q9JL75
Igh protein
2.0
86
80
Q505N9Q505N9Q505N9Q505N9
Vh gene product
2.0
84
80
A2NUE8A2NUE8A2NUE8A2NUE8
Tolloid-like protein 1
2.0
47
85
TLL1TLL1O43897O43897celldifferentiationcollagenfibrilorganizationdorsal/ventralpatternformationproteinprocessingskeletalsystemdevelopment
Ras-related protein Rab-27B
2.0
nan
91
RB27BRB27BQ99P58Q99P58anterogradeaxonalproteintransportexocytosismultivesicularbodysortingpathwaypositiveregulationofexocytosisregulationofexocytosissynapticvesicleendocytosisvesicle-mediatedtransport
Beta-1 adrenergic receptor
2.1
34
88
ADRB1ADRB1P08588P08588activationofadenylatecyclaseactivityadenylatecyclase-activatingadrenergicreceptorsignalingpathwaybrownfatcelldifferentiationdietinducedthermogenesisfearresponseheatgenerationnegativeregulationofmulticellularorganismgrowthnorepinephrine-epinephrine-mediatedvasodilationinvolvedinregulationofsystemicarterialbloodpressurepositiveregulationofcold-inducedthermogenesispositiveregulationofGTPaseactivitypositiveregulationofheartratebyepinephrine-norepinephrinepositiveregulationoftheforceofheartcontractionbyepinephrine-norepinephrineregulationofcircadiansleep/wakecyclesleepresponsetocold
Phosphatidylcholine transfer protein
2.9
60
85
PPCTPPCTQ9UKL6Q9UKL6lipidtransportnegativeregulationofcold-inducedthermogenesisphospholipidtransport
BAG family molecular chaperone regulator 1
4.2
42
77
✔
BAG1BAG1Q99933Q99933apoptoticprocesscellsurfacereceptorsignalingpathwaychaperonecofactor-dependentproteinrefoldingnegativeregulationofapoptoticprocessproteinstabilization
Ciliogenesis and planar polarity effector 2
4.6
79
64
CPLN2CPLN2A2A825A2A825axonemeassemblyciliumassemblycranialskeletalsystemdevelopmentendocardialcushionfusionexocytosislimbdevelopmentproteinlocalizationproteinprocessingproteintransportregulationofexocytosisregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningregulationofvesiclefusionsmoothenedsignalingpathway
Interleukin-2
5.1
54
68
IL2IL2P60568P60568activatedTcellproliferationadaptiveimmuneresponsecelladhesioncell-cellsignalingextrinsicapoptoticsignalingpathwayinabsenceofligandimmuneresponseleukocyteactivationinvolvedinimmuneresponsenaturalkillercellactivationnegativeregulationofapoptoticprocessnegativeregulationofBcellapoptoticprocessnegativeregulationofheartcontractionnegativeregulationofinflammatoryresponsenegativeregulationoflymphocyteproliferationnegativeregulationofproteinphosphorylationnegativeregulationofT-helper17celldifferentiationpositiveregulationofactivatedTcellproliferationpositiveregulationofBcellproliferationpositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriticspinedevelopmentpositiveregulationofimmunoglobulinproductionpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-17productionpositiveregulationofisotypeswitchingtoIgGisotypespositiveregulationofplasmacelldifferentiationpositiveregulationofregulatoryTcelldifferentiationpositiveregulationoftissueremodelingpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinproteinkinaseC-activatingGprotein-coupledreceptorsignalingpathwayregulationofCD4-positivealpha-betaTcellproliferationregulationofTcellhomeostaticproliferationresponsetoethanolTcelldifferentiationtranscriptionbyRNApolymeraseIItyrosinephosphorylationofSTATprotein
Serine/threonine-protein kinase Chk1
5.7
nan
66
CHK1CLSPNO14757Q9HAW4apoptoticprocessapoptoticprocessinvolvedindevelopmentcellularresponsetocaffeinecellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamagecheckpointsignalingDNArepairDNAreplicationG2/MtransitionofmitoticcellcycleinnercellmasscellproliferationintracellularsignaltransductionmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointnegativeregulationofDNAbiosyntheticprocessnegativeregulationofG0toG1transitionnegativeregulationofmitoticnucleardivisionnucleusorganizationpeptidyl-threoninephosphorylationpositiveregulationofcellcycleproteinphosphorylationregulationofcellpopulationproliferationregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofhistoneH3-K9acetylationregulationofmitoticcentrosomeseparationregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoUV-inducedDNAdamagereplicativesenescencesignaltransductioninresponsetoDNAdamagetranscriptioninitiation-coupledchromatinremodelingactivationofproteinkinaseactivityDNAreplicationcheckpointsignalingmitoticDNAreplicationcheckpointsignalingpeptidyl-serinephosphorylation
Three prime repair exonuclease 2
8.3
81
41
TREX2TREX2Q9R1A9Q9R1A9DNAcatabolicprocessexonucleolyticDNAmetabolicprocessDNArepair
Ral guanine nucleotide dissociation stimulator-like 2
8.3
61
48
RGL2RGL2Q61193Q61193negativeregulationofcardiacmusclecellapoptoticprocesspositiveregulationofGTPaseactivitypositiveregulationofphosphatidylinositol3-kinasesignalingRasproteinsignaltransductionregulationofRalproteinsignaltransduction
RNA-binding motif, single-stranded-interacting protein 1
8.4
67
47
RBMS1RBMS1P29558P29558DNAreplicationRNAprocessing
F-box/WD repeat-containing protein 8
9.4
nan
43
✔
FBXW8SKP1Q8N3Y1P63208cellpopulationproliferationGolgiorganizationlabyrinthinelayerbloodvesseldevelopmentpositiveregulationofdendritemorphogenesispositiveregulationoftranscriptionfactorcatabolicprocessproteinubiquitinationspongiotrophoblastlayerdevelopmentchromatinremodelingmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocess
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
3.0
57
78
SYEPAIMP2P07814Q13155cellularresponsetoinsulinstimuluscellularresponsetotypeIIinterferonglutamyl-tRNAaminoacylationnegativeregulationoftranslationprolyl-tRNAaminoacylationprotein-containingcomplexassemblyregulationoflong-chainfattyacidimportintocelltRNAaminoacylationforproteintranslationapoptoticprocessnegativeregulationofcellpopulationproliferationpositiveregulationofaminoacyl-tRNAligaseactivitypositiveregulationofneurondeathpositiveregulationofproteinubiquitinationproteinubiquitinationtranslationtypeIIpneumocytedifferentiation
Geranylgeranyl pyrophosphate synthase
7.2
67
50
✔
GGPPSGGPPSO95749O95749farnesyldiphosphatebiosyntheticprocessgeranyldiphosphatebiosyntheticprocessgeranylgeranyldiphosphatebiosyntheticprocessisoprenoidbiosyntheticprocessisoprenoidmetabolicprocess
Meteorin
2.0
40
87
METRNMETRNQ8C1Q4Q8C1Q4axonogenesisglialcelldifferentiationpositiveregulationofaxonogenesisradialglialcelldifferentiation
Anti-myosin immunoglobulin heavy chain variable region
2.0
86
80
Q9JL85Q9JL85Q9JL85Q9JL85
40S ribosomal protein S21
3.2
80
74
G1TM82G1TM82G1TM82G1TM82cytoplasmictranslation
MOB-like protein phocein
3.2
66
88
PHOCNPHOCNQ9Y3A3Q9Y3A3
Neuronal calcium sensor 1
6.8
61
59
NCS1NCS1P62168P62168phosphatidylinositol-mediatedsignalingpositiveregulationofexocytosisregulationofneuronprojectiondevelopmentregulationofpresynapticcytosoliccalciumionconcentrationregulationofsynapticvesicleexocytosis
Erythropoietin
2.0
54
89
EPOEPOP01588P01588acute-phaseresponseagingbloodcirculationcellularhyperosmoticresponseembryoimplantationerythrocytedifferentiationerythrocytematurationerythropoietin-mediatedsignalingpathwayhemoglobinbiosyntheticprocessmyeloidcellapoptoticprocessnegativeregulationofcalciumiontransportintocytosolnegativeregulationofcationchannelactivitynegativeregulationoferythrocyteapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoosmoticstressnegativeregulationofneurondeathnegativeregulationoftranscriptionbyRNApolymeraseIIpeptidyl-serinephosphorylationpositiveregulationofactivatedTcellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofERK1andERK2cascadepositiveregulationofneurondifferentiationpositiveregulationofneuronprojectiondevelopmentpositiveregulationofproteinkinaseactivitypositiveregulationofRasproteinsignaltransductionpositiveregulationoftyrosinephosphorylationofSTATproteinresponsetoaxoninjuryresponsetodexamethasoneresponsetoelectricalstimulusresponsetoestrogenresponsetohyperoxiaresponsetohypoxiaresponsetointerleukin-1responsetolipopolysaccharideresponsetosaltstressresponsetotestosteroneresponsetovitaminAsignaltransduction
E3 ubiquitin-protein ligase NEDD4
2.0
nan
86
NEDD4UBBP46934P0CG53cellularresponsetoUVformationofstructureinvolvedinasymbioticprocessglucocorticoidreceptorsignalingpathwaylysosomaltransportnegativeregulationofsodiumiontransmembranetransporteractivitynegativeregulationofsodiumiontransportnegativeregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoUV-inducedDNAdamagenegativeregulationofvascularendothelialgrowthfactorreceptorsignalingpathwayneuromuscularjunctiondevelopmentneuronprojectiondevelopmentpositiveregulationofnucleocytoplasmictransportpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteincatabolicprocessprogesteronereceptorsignalingpathwayproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK63-linkedubiquitinationproteinpolyubiquitinationproteintargetingtolysosomeproteinubiquitinationreceptorcatabolicprocessreceptorinternalizationregulationofdendritemorphogenesisregulationofiontransmembranetransportregulationofmacroautophagyregulationofmembranepotentialregulationofpotassiumiontransmembranetransporteractivityregulationofsynapseorganizationresponsetocalciumionubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayviralbuddingenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
T cell receptor delta variable 3
2.0
83
82
TRDV3TRDV3A0JD37A0JD37adaptiveimmuneresponseimmuneresponseinnateimmuneresponse
TNFAIP3-interacting protein 2
2.0
34
89
TNIP2TNIP2Q8NFZ5Q8NFZ5apoptoticprocessCD40signalingpathwaycellularresponsetolipopolysaccharideinflammatoryresponseinterleukin-1-mediatedsignalingpathwaynegativeregulationofendothelialcellapoptoticprocesspositiveregulationofBcellactivationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofmacrophageactivationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationregulationoftranscriptionbyRNApolymeraseIItoll-likereceptor2signalingpathwaytoll-likereceptor3signalingpathwaytoll-likereceptor9signalingpathway
Tumor necrosis factor
2.0
51
85
C1K3N5C1K3N5C1K3N5C1K3N5immuneresponsenecroptoticsignalingpathwayproteinlocalizationtoplasmamembraneregulationofbiologicalqualityregulationofdevelopmentalprocessregulationofmulticellularorganismalprocessregulationofsecretionvascularendothelialgrowthfactorproduction
F-BAR domain only protein 2
2.0
nan
88
FCHO2FCHO2Q96CF5Q96CF5clathrincoatassemblyclathrin-dependentendocytosismembraneinvaginationproteinlocalizationtoplasmamembranesynapticvesicleendocytosis
Cation-dependent mannose-6-phosphate receptor
2.0
70
85
MPRDMPRDP11456P11456lysosomaltransportproteintargetingtolysosomesecretionoflysosomalenzymes
Anti-MOG Z12 variable gamma 2a
2.0
83
80
Q8VDC9Q8VDC9Q8VDC9Q8VDC9
Sex hormone-binding globulin
2.0
59
83
SHBGSHBGP04278P04278
Lipocalin-1
2.0
45
88
LCN1LCN1P31025P31025proteolysisresponsetostimulusretinahomeostasissensoryperceptionoftaste
Myosin-reactive immunoglobulin heavy chain variable region
2.0
84
80
Q9UL95Q9UL95Q9UL95Q9UL95
Protein S100-A7A
2.0
49
86
S1A7AS1A7AQ86SG5Q86SG5
Guanine nucleotide exchange factor VAV2
2.1
nan
87
VAV2TXNIPP52735Q9H3M7angiogenesiscellmigrationcellularresponsetoxenobioticstimulusFc-epsilonreceptorsignalingpathwayFc-gammareceptorsignalingpathwayinvolvedinphagocytosislamellipodiumassemblyplateletactivationpositiveregulationofphosphatidylinositol3-kinaseactivityregulationofcellsizeregulationofGTPaseactivityregulationofsmallGTPasemediatedsignaltransductionsignaltransductionsmallGTPasemediatedsignaltransductionvascularendothelialgrowthfactorreceptorsignalingpathwaycellcyclecellularresponsetotumorcellkeratinocytedifferentiationnegativeregulationofcelldivisionnegativeregulationoftranscriptionbyRNApolymeraseIIplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofapoptoticprocessproteinimportintonucleusproteintransportregulationofcellpopulationproliferationresponsetocalciumionresponsetoestradiolresponsetoglucoseresponsetohydrogenperoxideresponsetomechanicalstimulusresponsetoprogesteroneresponsetoxenobioticstimulus
Mitochondrial cardiolipin hydrolase
3.6
nan
93
PLD6PLD6Q5SWZ9Q5SWZ9DNAmethylationinvolvedingametegenerationlipidcatabolicprocessmeioticcellcyclemitochondrialfusionPgranuleorganizationpiRNAprocessingpositiveregulationofmitochondrialfusionspermatiddevelopment
Brefeldin A-inhibited guanine nucleotide-exchange protein 2
5.0
nan
77
BIG2BIG2Q9Y6D5Q9Y6D5endomembranesystemorganizationendosomeorganizationexocytosisGolgitoplasmamembranetransportintracellularsignaltransductionpositiveregulationoftumornecrosisfactorproductionproteintransportreceptorrecyclingregulationofARFproteinsignaltransduction
Amyloid-beta A4 protein
2.0
53
88
H7C0V9H7C0V9H7C0V9H7C0V9
Calcium homeostasis modulator protein 4
4.2
nan
82
CAHM4CAHM4Q5JW98Q5JW98
Transcription initiation factor IIA subunit 1
8.6
72
38
TF2AAT2AGP52655P52657positiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoter
Vam6/Vps39-like protein
7.1
51
57
VPS39VPS39Q96JC1Q96JC1autophagosome-lysosomefusionautophagyendocyticrecyclingendosomalvesiclefusionendosometolysosometransportintracellularproteintransportlateendosometolysosometransportregulationofSNAREcomplexassembly
Major urinary protein 10
2.0
nan
92
A2BIN1A2BIN1A2BIN1A2BIN1
Histamine H2 receptor
2.0
nan
90
HRH2HRH2P25021P25021chemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengergastricacidsecretionimmuneresponsepositiveregulationofvasoconstriction
Sprouty-related, EVH1 domain-containing protein 1
6.5
nan
63
SPRE1SPRE1Q7Z699Q7Z699negativeregulationofangiogenesisnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofepithelialtomesenchymaltransitionnegativeregulationofERK1andERK2cascadenegativeregulationoflensfibercelldifferentiationnegativeregulationofMAPKcascadenegativeregulationofpeptidyl-threoninephosphorylationnegativeregulationofproteinkinaseactivitynegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofDNAdamageresponsesignaltransductionbyp53classmediatorregulationofMAPKcascaderegulationofproteindeacetylationvasculogenesisinvolvedincoronaryvascularmorphogenesis
Megakaryocyte and platelet inhibitory receptor G6b
2.0
67
83
G6BG6BO95866O95866bloodcoagulationerythrocytedifferentiationintegrin-mediatedsignalingpathwaymegakaryocytedevelopmentmegakaryocytedifferentiationnegativeregulationofsignaltransductionplateletformation
14-3-3 protein gamma
9.6
nan
43
1433GNED4LP61981Q96PU5cellularresponsetoinsulinstimulusnegativeregulationofproteinkinaseactivityproteintargetingregulationofneurondifferentiationregulationofsignaltransductionregulationofsynapticplasticitysignaltransductioncelldifferentiationiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransporteractivitynegativeregulationofproteinlocalizationtocellsurfacenegativeregulationofsodiumiontransmembranetransportnegativeregulationofsodiumiontransmembranetransporteractivitypositiveregulationofcaveolin-mediatedendocytosispositiveregulationofdendriteextensionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofdendritemorphogenesisregulationofiontransmembranetransportregulationofmembranedepolarizationregulationofmembranepotentialregulationofmembranerepolarizationregulationofpotassiumiontransmembranetransporteractivityregulationofproteinstabilityregulationofsodiumiontransmembranetransportubiquitin-dependentproteincatabolicprocessventricularcardiacmusclecellactionpotential
Succinate receptor 1
2.0
41
89
SUCR1SUCR1Q6IYF9Q6IYF9Gprotein-coupledreceptorsignalingpathwayglucosehomeostasismacrophageactivationinvolvedinimmuneresponsepositiveregulationofchemotaxispositiveregulationofinflammatoryresponseregulationofangiotensinmetabolicprocessreninsecretionintobloodstreamresponsetocalciumion
RB1-inducible coiled-coil protein 1
8.5
53
48
RBCC1RBCC1Q8TDY2Q8TDY2autophagosomeassemblyautophagyautophagyofmitochondrionautophagyofperoxisomecellcycleextrinsicapoptoticsignalingpathwayglycophagyheartdevelopmentliverdevelopmentnegativeregulationofcellpopulationproliferationnegativeregulationofextrinsicapoptoticsignalingpathwaypiecemealmicroautophagyofthenucleuspositiveregulationofautophagypositiveregulationofcellsizepositiveregulationofJNKcascadepositiveregulationofproteinphosphorylationproteinautophosphorylationproteinphosphorylationregulationofproteinlipidationreticulophagy
GTPase HRas
3.7
94
nan
RASHRASHP01112P01112adiposetissuedevelopmentanimalorganmorphogenesiscellsurfacereceptorsignalingpathwaycellularresponsetogammaradiationcellularsenescencechemotaxisdefenseresponsetoprotozoanendocytosisfibroblastproliferationinsulinreceptorsignalingpathwayintrinsicapoptoticsignalingpathwayMAPKcascadenegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofGTPaseactivitynegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofactincytoskeletonreorganizationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofepithelialcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationoffibroblastproliferationpositiveregulationofGTPaseactivitypositiveregulationofJNKcascadepositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmiRNAmetabolicprocesspositiveregulationofphospholipaseCactivitypositiveregulationofproteinphosphorylationpositiveregulationofproteintargetingtomembranepositiveregulationofruffleassemblypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionpositiveregulationofwoundhealingRasproteinsignaltransductionregulationofcellcycleregulationofcellpopulationproliferationregulationoflong-termneuronalsynapticplasticityregulationofMAPkinaseactivityregulationofneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneregulationoftranscriptionbyRNApolymeraseIIsignaltransductionTcellreceptorsignalingpathwayT-helper1typeimmuneresponse
NADH-ubiquinone oxidoreductase chain 5
5.8
101
45
NU5MNU5MP03921P03921aerobicrespirationelectrontransportcoupledprotontransportmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetohydrogenperoxideresponsetohypoxiaresponsetoorganonitrogencompound
ABO blood group (Transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
7.2
60
nan
D3HIC2D3HIC2D3HIC2D3HIC2carbohydratemetabolicprocess
Lymphotactin
2.0
82
80
✔
XCL1XCL1P47992P47992antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerleukin-1cellularresponsetointerleukin-4cellularresponsetotransforminggrowthfactorbetastimuluscellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwayGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismaturenaturalkillercellchemotaxismonocytechemotaxisnegativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofinterleukin-2productionnegativeregulationofTcellcytokineproductionnegativeregulationofT-helper1cellactivationnegativeregulationofT-helper1typeimmuneresponsenegativeregulationoftypeIIinterferonproductionneutrophilchemotaxispositiveregulationofBcellchemotaxispositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofCD8-positivealpha-betaTcellproliferationpositiveregulationofERK1andERK2cascadepositiveregulationofgranzymeAproductionpositiveregulationofgranzymeBproductionpositiveregulationofGTPaseactivitypositiveregulationofimmunoglobulinproductioninmucosaltissuepositiveregulationofinterleukin-10productionpositiveregulationofleukocytechemotaxispositiveregulationofnaturalkillercellchemotaxispositiveregulationofneutrophilchemotaxispositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofTcellchemotaxispositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofT-helper1cellcytokineproductionpositiveregulationofT-helper2cellcytokineproductionpositiveregulationofthymocytemigrationpositiveregulationoftransforminggrowthfactorbetaproductionregulationofinflammatoryresponsereleaseofsequesteredcalciumionintocytosolresponsetovirussignaltransduction
Protein Nef
2.0
74
81
Q4JGV0AP2S1Q4JGV0P62744mitigationofhostantiviraldefenseresponseclathrin-dependentendocytosisintracellularproteintransportpostsynapticneurotransmitterreceptorinternalizationsynapticvesicleendocytosisvesicle-mediatedtransport
Tubulinyl-Tyr carboxypeptidase 2
2.1
76
83
VASH2TBA1BQ86V25P68363axondevelopmentcell-cellfusionlabyrinthinelayerbloodvesseldevelopmentpositiveregulationofangiogenesispositiveregulationofendothelialcellproliferationproteolysisregulationofangiogenesissyncytiumformationbyplasmamembranefusioncelldivisioncellularresponsetointerleukin-4cytoskeleton-dependentintracellulartransportmicrotubulecytoskeletonorganizationmicrotubule-basedprocessmitoticcellcycle
Ribosomal oxygenase 1
2.0
74
81
RIOX1RL8Q9H6W3P62917chromatinorganizationhistoneH3-K36demethylationhistoneH3-K4demethylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofosteoblastdifferentiationcytoplasmictranslationtranslation
Mitochondrial import receptor subunit TOM20 homolog
2.0
nan
91
✔
TOM20ALDH2Q62760P11884proteinimportintomitochondrialmatrixproteintargetingtomitochondrion"responseto335-triiodo-L-thyronine"responsetomuscleactivitytRNAimportintomitochondrionacetaldehydemetabolicprocessaldehydecatabolicprocessapoptoticmitochondrialchangesbehavioralresponsetoethanolcellulardetoxificationofaldehydecellularresponsetofattyacidcellularresponsetohormonestimuluscellularresponsetoresveratrolethanolcatabolicprocessethanolmetabolicprocessintrinsicapoptoticsignalingpathwayinresponsetooxidativestressliverdevelopmentnegativeregulationofapoptoticprocessregulationofdopaminebiosyntheticprocessregulationofinflammatoryresponseregulationofreactiveoxygenspeciesmetabolicprocessregulationofresponsetooxidativestressregulationofserotoninbiosyntheticprocessresponsetoestradiolresponsetoethanolresponsetoheatresponsetohyperoxiaresponsetoischemiaresponsetolipopolysaccharideresponsetonicotineresponsetoorganiccycliccompoundresponsetoprogesteroneresponsetotestosterone
Alpha-1-antitrypsin
2.1
nan
90
✔
A1ATA1ATP01009P01009acute-phaseresponsebloodcoagulationnegativeregulationofendopeptidaseactivity
Periphilin-1
8.0
64
46
✔
PPHLNPPHLNQ8NEY8Q8NEY8keratinizationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionepigeneticpositiveregulationofDNAmethylation-dependentheterochromatinformationproteinlocalizationtoheterochromatin
Corticosteroid-binding globulin
2.1
nan
88
CBGCBGP08185P08185glucocorticoidmetabolicprocessnegativeregulationofendopeptidaseactivity
Hepatopancreas trypsin
8.6
97
40
Q52V24BPT1Q52V24P00974proteolysisnegativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Short transient receptor potential channel 4
1.9
48
86
TRPC4TRPC4Q9QUQ5Q9QUQ5calciumionimportcalciumiontransmembranetransportcalciumiontransportgamma-aminobutyricacidsecretionoligodendrocytedifferentiationpositiveregulationofstore-operatedcalciumentryregulationofactionpotentialfiringrateregulationofcalciumiontransportregulationofcytosoliccalciumionconcentration
Amyloid lambda 6 light chain variable region PIP
2.0
90
81
Q96JD1Q96JD1Q96JD1Q96JD1
Major prion protein
2.0
86
82
Q4FJQ7Q4FJQ7Q4FJQ7Q4FJQ7calcium-mediatedsignalingusingintracellularcalciumsourcecellularresponsetoamyloid-betacellularresponsetocopperionlearningormemorynegativeregulationofapoptoticprocessnegativeregulationofcatalyticactivitynegativeregulationoflong-termsynapticpotentiationpositiveregulationofneuronapoptoticprocesspositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteintyrosinekinaseactivityproteindestabilizationproteinhomooligomerizationregulationofintracellularcalciumactivatedchloridechannelactivityresponsetocadmiumion
IGL@ protein
2.0
89
78
Q6PJR7Q6PJR7Q6PJR7Q6PJR7
5-hydroxytryptamine receptor 3A
2.0
76
82
5HT3A5HT3AP23979P23979chemicalsynaptictransmissioninorganiccationtransmembranetransportiontransmembranetransportnervoussystemprocesspositiveregulationofiontransmembranetransporteractivityregulationofmembranepotentialserotoninreceptorsignalingpathwaysignaltransduction
Acid sphingomyelinase-like phosphodiesterase 3b
2.0
56
88
ASM3BASM3BP58242P58242inflammatoryresponseinnateimmuneresponsemembranelipidcatabolicprocessnegativeregulationofinflammatoryresponsenegativeregulationofinnateimmuneresponsenegativeregulationoftoll-likereceptorsignalingpathwaysphingomyelincatabolicprocess
Exostosin-like 2
2.0
77
82
EXTL2EXTL2Q9ES89Q9ES89N-acetylglucosaminemetabolicprocessUDP-N-acetylgalactosaminemetabolicprocess
Osteocalcin
2.1
56
86
OSTCNOSTCNP02820P02820biomineraltissuedevelopmentbonedevelopmentosteoblastdifferentiationregulationofbonemineralizationregulationofcellularresponsetoinsulinstimulusresponsetovitaminK
Phospholipase B-like 1
2.1
81
79
PLBL1PLBL1Q9GL30Q9GL30phospholipidcatabolicprocess
Endoribonuclease ZC3H12A
2.6
49
90
ZC12AZC12AQ5D1E7Q5D1E7"3-UTR-mediatedmRNAdestabilization"angiogenesisapoptoticprocesscelldifferentiationcellularresponsetochemokinecellularresponsetoDNAdamagestimuluscellularresponsetoglucosestarvationcellularresponsetointerleukin-1cellularresponsetoionomycincellularresponsetolipopolysaccharidecellularresponsetooxidativestresscellularresponsetosodiumarsenitecellularresponsetotumornecrosisfactorcellularresponsetovirusimmuneresponse-activatingsignalingpathwayinflammatoryresponsemiRNAcatabolicprocessnegativeregulationbyhostofviralgenomereplicationnegativeregulationofcardiacmusclecontractionnegativeregulationofcytokineproductioninvolvedininflammatoryresponsenegativeregulationofgeneexpressionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinterleukin-1betaproductionnegativeregulationofinterleukin-6productionnegativeregulationofmusclecellapoptoticprocessnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofnitricoxidebiosyntheticprocessnegativeregulationofproteinphosphorylationnegativeregulationofT-helper17celldifferentiationnegativeregulationoftumornecrosisfactorproductionnegativeregulationoftypeIIinterferonproductionnervoussystemdevelopmentnuclear-transcribedmRNAcatabolicprocessendonucleolyticcleavage-dependentdecaypositiveregulationofangiogenesispositiveregulationofautophagypositiveregulationofcelldeathpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofendothelialcellmigrationpositiveregulationofexecutionphaseofapoptosispositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationoflipidstoragepositiveregulationofmiRNAcatabolicprocesspositiveregulationofmRNAcatabolicprocesspositiveregulationofp38MAPKcascadepositiveregulationofproteindeubiquitinationpositiveregulationofproteinimportintonucleuspositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIproteincomplexoligomerizationproteindeubiquitinationregulationofgeneexpressionRNAphosphodiesterbondhydrolysisRNAphosphodiesterbondhydrolysisendonucleolyticTcellreceptorsignalingpathway
Methylcytosine dioxygenase TET3
3.7
35
89
TET3TET3L0HN04L0HN045-methylcytosinecatabolicprocesschromatinorganizationDNAdemethylationDNAdemethylationofmalepronucleusoxidativedemethylationpositiveregulationoftranscriptionbyRNApolymeraseIIproteinO-linkedglycosylation
Cytosolic 10-formyltetrahydrofolate dehydrogenase
3.9
100
65
AL1L1AL1L1Q5HZB2Q5HZB210-formyltetrahydrofolatecatabolicprocessbileacidsignalingpathwayfolicacidmetabolicprocessNADPHregenerationone-carbonmetabolicprocesstetrahydrofolatebiosyntheticprocess
Growth arrest-specific protein 2
3.8
36
87
GAS2GAS2P11862P11862actincrosslinkformationantralovarianfolliclegrowthapoptoticprocessbasementmembraneorganizationcellcycleinitiationofprimordialovarianfolliclegrowthovulationregulationofcellcycleregulationofcellshaperegulationofNotchsignalingpathway
Glycerol-3-phosphate phosphatase
4.0
86
66
PGPPGPQ8CHP8Q8CHP8glycerolbiosyntheticprocessglycerophospholipidmetabolicprocessnegativeregulationofgluconeogenesis
Melatonin receptor type 1B
3.8
43
89
MTR1BMTR1BP49286P49286camera-typeeyedevelopmentchemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerglucosehomeostasisnegativeregulationofcGMP-mediatedsignalingnegativeregulationofcytosoliccalciumionconcentrationnegativeregulationofdelayedrectifierpotassiumchannelactivitynegativeregulationofinsulinsecretionnegativeregulationofneuronapoptoticprocessnegativeregulationoftransmissionofnerveimpulsenegativeregulationofvasoconstrictionpositiveregulationofcircadiansleep/wakecyclenon-REMsleeppositiveregulationoftransmissionofnerveimpulseregulationofinsulinsecretionregulationofneuronalactionpotential
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
5.4
76
56
PLCE1PLCE1Q99P84Q99P84diacylglycerolbiosyntheticprocessepidermalgrowthfactorreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayglomerulusdevelopmentlipidcatabolicprocessphosphatidylinositol-mediatedsignalingphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationoflamellipodiumassemblypositiveregulationofMAPKcascadeRasproteinsignaltransductionregulationofGprotein-coupledreceptorsignalingpathwayregulationofproteinkinaseactivityregulationofRasproteinsignaltransduction
Multiple PDZ domain protein
7.4
73
44
MPDZMPDZQ8VBX6Q8VBX6celladhesiondendritedevelopmentintracellularproteintransportmyelination
Nucleoside diphosphate-linked moiety X motif 17
7.6
73
51
NUD17NUD17P0C025P0C025NADcatabolicprocessNADHmetabolicprocessNADPcatabolicprocess
Serine hydroxymethyltransferase, mitochondrial
7.9
84
42
GLYMGLYMP34897P34897folicacidmetabolicprocessglycinebiosyntheticprocessfromserineglycinemetabolicprocessL-serinebiosyntheticprocessL-serinecatabolicprocessL-serinemetabolicprocessone-carbonmetabolicprocesspositiveregulationofcellpopulationproliferationproteinhomotetramerizationproteinK63-linkeddeubiquitinationproteintetramerizationpurinenucleobasebiosyntheticprocessregulationofaerobicrespirationregulationofmitochondrialtranslationregulationofoxidativephosphorylationresponsetotypeIinterferontetrahydrofolateinterconversiontetrahydrofolatemetabolicprocess
Omega-amidase NIT2
8.0
65
43
NIT2NIT2Q9JHW2Q9JHW2asparaginemetabolicprocessglutaminemetabolicprocessoxaloacetatemetabolicprocess
Protein diaphanous homolog 1
4.0
77
67
DIAP1DIAP1O08808O08808actincytoskeletonorganizationactinfilamentpolymerizationbraindevelopmentcellularresponsetohistaminecytoskeletonorganizationneuronprojectiondevelopmentpositiveregulationofcellmigrationproteinlocalizationtomicrotubuleregulationofcellshaperegulationofcytoskeletonorganizationregulationofmicrotubule-basedprocessregulationofreleaseofsequesteredcalciumionintocytosolsensoryperceptionofsoundsynapticvesicleendocytosis
Ankyrin-3
8.8
77
39
ANK3ANK3O70511O70511anterogradeaxonaltransportaxondevelopmentaxonguidanceaxonogenesiscellularresponsetomagnesiumionclusteringofvoltage-gatedsodiumchannelsestablishmentofproteinlocalizationestablishmentormaintenanceofmicrotubulecytoskeletonpolarityGolgitoplasmamembraneproteintransportmagnesiumionhomeostasismaintenanceofproteinlocationincellmaintenanceofproteinlocationinplasmamembranemembraneassemblymitoticcytokinesisnegativeregulationofdelayedrectifierpotassiumchannelactivitynegativeregulationofendocytosisneuromuscularjunctiondevelopmentneuronalactionpotentialplasmamembraneorganizationpositiveregulationofcationchannelactivitypositiveregulationofcellcommunicationbyelectricalcouplingpositiveregulationofgeneexpressionpositiveregulationofhomotypiccell-celladhesionpositiveregulationofmembranedepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofmembranepotentialpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofproteintargetingtomembranepositiveregulationofsodiumiontransmembranetransporteractivitypositiveregulationofsodiumiontransportproteinlocalizationtoaxonproteinlocalizationtoplasmamembraneregulationofpotassiumiontransportregulationofproteintargetingresponsetoimmobilizationstresssignaltransductionsynapseorganization
Tubulin beta chain
8.9
50
46
TBBTBBP02554P02554microtubulecytoskeletonorganizationmitoticcellcycle
cAMP-dependent protein kinase type II-alpha regulatory subunit
5.1
67
58
KAPCAKAP2P05132P12367adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellularresponsetocoldcellularresponsetoglucosestimuluscellularresponsetoheatcellularresponsetoparathyroidhormonestimulusmesodermformationmodulationofchemicalsynaptictransmissionmRNAprocessingnegativeregulationofmeioticcellcyclenegativeregulationofsmoothenedsignalingpathwayinvolvedindorsal/ventralneuraltubepatterningneuraltubeclosurepeptidyl-serinephosphorylationpeptidyl-threoninephosphorylationpositiveregulationofcellpopulationproliferationpositiveregulationofinsulinsecretionpositiveregulationofproteinexportfromnucleuspostsynapticmodulationofchemicalsynaptictransmissionproteinautophosphorylationproteinexportfromnucleusproteinkinaseAsignalingproteinlocalizationtolipiddropletproteinphosphorylationregulationofbicellulartightjunctionassemblyregulationofcellcycleregulationofcellularrespirationregulationofosteoblastdifferentiationregulationofproteasomalproteincatabolicprocessregulationofproteinprocessingregulationofsynaptictransmissionglutamatergicspermcapacitationspontaneousexocytosisofneurotransmitternegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivity
Partitioning defective 3 homolog
9.4
61
42
PARD3PARD3Q9Z340Q9Z340apicalconstrictionbicellulartightjunctionassemblycelladhesioncellcyclecelldivisioncentrosomelocalizationestablishmentofcellpolarityestablishmentofcentrosomelocalizationestablishmentofepithelialcellpolarityestablishmentormaintenanceofepithelialcellapical/basalpolaritymicrotubulecytoskeletonorganizationmyelinationinperipheralnervoussystemnegativeregulationofpeptidyl-threoninephosphorylationpositiveregulationofmyelinationpositiveregulationofreceptorinternalizationproteinlocalizationproteintargetingtomembraneregulationofactinfilament-basedprocessregulationofcellularlocalizationwoundhealingspreadingofcells
ETS translocation variant 4
2.0
62
83
ETV4ETV4P43268P43268celldifferentiationpositiveregulationofkeratinocytedifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Protein scribble homolog
2.0
83
79
✔
SCRIBSCRIBQ14160Q14160activationofGTPaseactivityapoptoticprocessinvolvedinmorphogenesisastrocytecellmigrationauditoryreceptorcellstereociliumorganizationcellmigrationcellpopulationproliferationcell-celladhesioncochlearnucleusdevelopmentestablishmentofapical/basalcellpolarityestablishmentofTcellpolarityestablishmentormaintenanceofepithelialcellapical/basalpolaritymammaryglandductmorphogenesisnegativeregulationofactivatedTcellproliferationnegativeregulationofmitoticcellcycleneuraltubeclosureneurotransmitterreceptortransportpostsynapticmembranetoendosomeneurotransmitterreceptortransportendosometopostsynapticmembranepolarizedepithelialcelldifferentiationpositivechemotaxispositiveregulationofapoptoticprocesspositiveregulationofreceptorrecyclingpositiveregulationoftypeIIinterferonproductionpost-analtailmorphogenesisproteinlocalizationtoadherensjunctionreceptorclusteringreceptorlocalizationtosynapseregulationofpostsynapticneurotransmitterreceptorinternalizationsynapticvesicleendocytosissynapticvesicletargetingwoundhealing
Zona pellucida sperm-binding protein 2
2.1
55
89
ZP2ZP2P20239P20239bindingofspermtozonapellucidapreventionofpolyspermy
Caspase recruitment domain-containing protein 11
2.0
56
81
CAR11CAR11Q9BXL7Q9BXL7BcelldifferentiationBcellproliferationCD4-positivealpha-betaTcellproliferationhomeostasisofnumberofcellsI-kappaBkinase/NF-kappaBsignalingpositiveregulationofBcellproliferationpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-2productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellreceptorsignalingpathwayproteinhomooligomerizationregulationofapoptoticprocessregulationofBcelldifferentiationregulationofTcelldifferentiationTcellcostimulationthymicTcellselectionTORC1signaling
Sorting nexin-25
2.1
54
83
SNX25SNX25Q3ZT31Q3ZT31negativeregulationofpathway-restrictedSMADproteinphosphorylationnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwayproteintransportreceptorcatabolicprocess
P2X purinoceptor 7
2.0
65
86
P2RX7P2RX7Q64663Q64663apoptoticsignalingpathwayATPexportblebassemblycalciumiontransportcationtransmembranetransportcationtransportcelldeathcellmorphogenesiscellsurfacereceptorsignalingpathwaycellvolumehomeostasiscellularresponsetodsRNAcellularresponsetoextracellularstimuluscellularresponsetoorganiccycliccompoundceramidebiosyntheticprocesscollagenmetabolicprocessdefenseresponsetoGram-positivebacteriumestablishmentoflocalizationincellexcitatorypostsynapticpotentialextrinsicapoptoticsignalingpathwaygamma-aminobutyricacidsecretiongeneexpressionglutamatesecretionhomeostasisofnumberofcellswithinatissueinflammatoryresponselymphocyteapoptoticprocessMAPKcascademembranedepolarizationmembraneproteinectodomainproteolysismitochondrialdepolarizationmitochondrionorganizationNADtransportnegativeregulationofboneresorptionnegativeregulationofcellvolumenegativeregulationofMAPKcascadeneuronalactionpotentialorganiccationtransportphagolysosomeassemblyphospholipidtransfertomembranephospholipidtranslocationplasmamembraneorganizationplasmamembranephospholipidscramblingporecomplexassemblypositiveregulationofapoptoticprocesspositiveregulationofblebassemblypositiveregulationofbonemineralizationpositiveregulationofcalciumiontransportintocytosolpositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofcytoskeletonorganizationpositiveregulationofgamma-aminobutyricacidsecretionpositiveregulationofgeneexpressionpositiveregulationofglutamatesecretionpositiveregulationofglycolyticprocesspositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofiontransmembranetransportpositiveregulationoflymphocyteapoptoticprocesspositiveregulationofmacrophagecytokineproductionpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmitochondrialdepolarizationpositiveregulationofossificationpositiveregulationofprostaglandinsecretionpositiveregulationofproteinphosphorylationpositiveregulationofproteinsecretionpositiveregulationofTcellapoptoticprocesspositiveregulationofTcellmediatedcytotoxicityprogrammedcelldeathprostaglandinsecretionproteincatabolicprocessproteinphosphorylationproteinprocessingproteinsecretionpurinergicnucleotidereceptorsignalingpathwayreactiveoxygenspeciesmetabolicprocessregulationofpresynapticdensecoregranuleexocytosisregulationofsodiumiontransportreleaseofsequesteredcalciumionintocytosolresponsetoATPresponsetobacteriumresponsetocalciumionresponsetoelectricalstimulusresponsetofluidshearstressresponsetolipopolysaccharideresponsetomechanicalstimulusresponsetoorganiccycliccompoundresponsetoorganicsubstanceresponsetoxenobioticstimulusresponsetozincionsensoryperceptionofpainskeletalsystemmorphogenesissynapticvesicleexocytosisTcellapoptoticprocessTcellhomeostasisTcellmediatedcytotoxicityTcellproliferationtransmembranetransportvesiclebuddingfrommembrane
Probable inactive tRNA-specific adenosine deaminase-like protein 3
3.9
93
74
ADAT3ADAT3Q6PAT0Q6PAT0tRNAprocessing
Transient receptor potential cation channel subfamily V member 5
4.3
57
69
TRPV5TRPV5Q9XSM3Q9XSM3calciumionhomeostasiscalciumionimportacrossplasmamembranecalciumiontransmembranetransportcalciumiontransportproteinhomotetramerizationregulationofurinevolume
Protein mono-ADP-ribosyltransferase PARP10
5.2
28
71
✔
PAR10PAR10Q53GL7Q53GL7chromatinorganizationNADbiosynthesisvianicotinamideribosidesalvagepathwaynegativeregulationoffibroblastproliferationnegativeregulationofgeneexpressionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofproteinK63-linkedubiquitinationproteinauto-ADP-ribosylationproteinpoly-ADP-ribosylationtranslesionsynthesisviralproteinprocessing
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
4.3
70
73
PDE6BPDE6BP23439P23439entrainmentofcircadianclockbyphotoperiodretinadevelopmentincamera-typeeyesignaltransductionvisualperception
28S ribosomal protein S6, mitochondrial
5.0
50
74
✔
RT06RT18CP82931P82917mitochondrialtranslationtranslation
Peroxisomal carnitine O-octanoyltransferase
3.5
66
78
OCTCOCTCQ9DC50Q9DC50carnitinemetabolicprocesscoenzymeAmetabolicprocessfattyacidbeta-oxidationfattyacidmetabolicprocessfattyacidtransportgenerationofprecursormetabolitesandenergymedium-chainfattyacidmetabolicprocessresponsetoxenobioticstimulus
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
7.2
76
44
PAOXPAOXQ8C0L6Q8C0L6polyaminecatabolicprocesspositiveregulationofspermidinebiosyntheticprocessputrescinebiosyntheticprocessputrescinecatabolicprocessspermidinecatabolicprocesssperminecatabolicprocess
Perforin-1
2.0
58
87
PERFPERFP10820P10820apoptoticprocesscircadianrhythmcytolysisdefenseresponsetotumorcelldefenseresponsetovirusimmuneresponsetotumorcellimmunologicalsynapseformationpositiveregulationofkillingofcellsofanotherorganismproteinhomooligomerizationTcellmediatedcytotoxicity
Espin
3.9
83
68
ESPNESPNQ9ET47Q9ET47actinfilamentbundleassemblyactinfilamentnetworkformationlocomotorybehaviormicrovillaractinbundleassemblynegativeregulationofcytoskeletonorganizationparallelactinfilamentbundleassemblypositiveregulationoffilopodiumassemblysensoryperceptionofsound
Protein Hook homolog 1
7.6
69
48
HOOK1HOOK1Q8BIL5Q8BIL5cytoplasmicmicrotubuleorganizationcytoskeleton-dependentintracellulartransportearlyendosometolateendosometransportendosomeorganizationendosometolysosometransportGolgiorganizationlysosomeorganizationmanchetteassemblyproteinlocalizationtoperinuclearregionofcytoplasmproteintransportspermatiddevelopment
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial
7.9
99
34
✔
ODB2ODB2P11181P11181branched-chainaminoacidcatabolicprocess
F-actin-uncapping protein LRRC16A
3.6
72
74
CARL1CARL1Q6EDY6Q6EDY6actinfilamentnetworkformationbarbed-endactinfilamentuncappingcellmigrationestablishmentormaintenanceofcellpolaritylamellipodiumassemblymacropinocytosisnegativeregulationofbarbed-endactinfilamentcappingpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellmigrationpositiveregulationoflamellipodiumorganizationpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingregulationofactincytoskeletonreorganizationregulationofArp2/3complex-mediatedactinnucleationruffleorganizationuratemetabolicprocess
Teratocarcinoma-derived growth factor
2.0
34
88
TDGF1TDGF1P51865P51865anatomicalstructuredevelopmentanterior/posterioraxisspecificationanterior/posterioraxisspecificationembryoanterior/posteriorpatternspecificationbloodvesseldevelopmentcardiacmusclecelldifferentiationcelldifferentiationdeterminationofleft/rightsymmetryfibroblastproliferationgastrulationheartdevelopmentinuteroembryonicdevelopmentmorphogenesisofabranchingstructurenegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaynodalsignalingpathwaypositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcell-matrixadhesionpositiveregulationoffibroblastproliferationpositiveregulationofMAPkinaseactivitypositiveregulationoftranscriptionbyRNApolymeraseIIregulationoffibroblastmigrationregulationofsignaltransductionvasculogenesis
Nuclear receptor coactivator 1
9.5
60
37
NCOA1NCOA1Q15788Q15788cellularresponsetohormonestimuluscellularresponsetoThyroglobulintriiodothyroninelabyrinthinelayermorphogenesismRNAtranscriptionbyRNApolymeraseIIperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofadiposetissuedevelopmentpositiveregulationofapoptoticprocesspositiveregulationofDNA-templatedtranscriptionpositiveregulationofneurondifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterbygalactoseregulationofcellularresponsetoinsulinstimulusregulationofthyroidhormonemediatedsignalingpathway
Myelin-oligodendrocyte glycoprotein
2.0
81
81
MOGMOGQ63345Q63345agingcelladhesionregulationofcytokineproductionresponsetofolicacidresponsetolipidTcellreceptorsignalingpathway
Atrial natriuretic peptide receptor 1
2.0
31
89
ANPRAANPRAP18910P18910bloodvesseldiametermaintenancecellsurfacereceptorsignalingpathwaycGMPbiosyntheticprocesscGMP-mediatedsignalingdopaminemetabolicprocessintracellularsignaltransductionnegativeregulationofsmoothmusclecellproliferationpositiveregulationofcGMP-mediatedsignalingproteinphosphorylationreceptorguanylylcyclasesignalingpathwayregulationofbloodpressuresignaltransduction
Chymotrypsin-like elastase family member 2A
2.0
71
84
CEL2ACEL2AP08419P08419insulincatabolicprocessproteolysisregulationofinsulinsecretionregulationofplateletaggregationresponsetoinsulin
Cytochrome c oxidase subunit 2
2.8
97
65
COX2COX2P68530P68530
BRCA1-A complex subunit Abraxas 1
3.4
60
74
ABRX1ABRX1Q8BPZ8Q8BPZ8attachmentofspindlemicrotubulestokinetochorechromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointmitoticspindleassemblypositiveregulationofDNArepairproteinK63-linkeddeubiquitinationregulationofDNArepairresponsetoionizingradiation
Sodium/iodide cotransporter
2.0
nan
89
SC5A5SC5A5Q63008Q63008aniontransmembranetransportcellularresponsetocAMPcellularresponsetoforskolincellularresponsetogonadotropinstimuluscellularresponsetoThyroidstimulatinghormoneiodidetransmembranetransportiodidetransportsodiumiontransmembranetransportsodiumiontransportthyroidhormonegenerationtransmembranetransport
Plexin-A3
7.0
59
57
PLXA3PLXA3A5D6Q5A5D6Q5axonextensioninvolvedinaxonguidanceaxonguidancebranchiomotorneuronaxonguidancefacialnervestructuralorganizationgonadotrophin-releasinghormoneneuronalmigrationtothehypothalamushippocampusdevelopmentnegativechemotaxisnegativeregulationofaxonextensioninvolvedinaxonguidancenegativeregulationofcelladhesionneuronprojectionextensionneuronprojectionguidanceolfactorynerveformationpositiveregulationofaxonogenesispositiveregulationofcytoskeletonorganizationpyramidalneurondevelopmentregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivitysemaphorin-plexinsignalingpathwayinvolvedinaxonguidancetrigeminalnervestructuralorganization
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
7.8
57
45
PHKG1PHKG1P00518P00518glycogenbiosyntheticprocessproteinphosphorylation
Lutropin subunit beta
2.0
42
91
LSHBLSHBP04651P04651Gprotein-coupledreceptorsignalingpathway
Proteasome activator complex subunit 1
2.0
nan
88
✔
PSME1PSME2P97371P97372antigenprocessingandpresentationofexogenousantigenpositiveregulationofendopeptidaseactivityregulationofG1/Stransitionofmitoticcellcycleregulationofproteasomalproteincatabolicprocess
Transmembrane emp24 domain-containing protein 10
2.1
71
81
TMEDATMEDAQ63584Q63584COPI-coatedvesiclebuddingcytosoltoERGICproteintransportendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationintracellularproteintransportkidneydevelopmentnegativeregulationofaspartic-typeendopeptidaseactivityinvolvedinamyloidprecursorproteincatabolicprocesspositiveregulationofinterleukin-1productionpositiveregulationofproteinsecretionproteinlocalizationtoERGICregulatedexocytosisregulationofamyloid-betaformationresponsetoalkaloidretrogradevesicle-mediatedtransportGolgitoendoplasmicreticulumvesicletargetingvesicletargetingtofromorwithinGolgi
Single chain Fv
2.1
87
80
Q9HCC1Q9HCC1Q9HCC1Q9HCC1
Cytochrome b
4.3
71
70
CYBCYBP00157P00157mitochondrialelectrontransportubiquinoltocytochromecrespiratoryelectrontransportchain
Signal recognition particle receptor subunit beta
7.7
84
36
✔
SRPRBSRPRBP47758P47758proteintargetingtoERSRP-dependentcotranslationalproteintargetingtomembranesignalsequencerecognition
Interleukin-13
2.0
44
87
Q4VB50Q4VB50Q4VB50Q4VB50immuneresponsenegativeregulationofcomplement-dependentcytotoxicitynegativeregulationofendothelialcellapoptoticprocess
Beta-chain
2.0
86
82
A2NTY6A2NTY6A2NTY6A2NTY6
Translational activator of cytochrome c oxidase 1
7.6
61
56
TACO1TACO1Q8K0Z7Q8K0Z7mitochondrialcytochromecoxidaseassemblymotorlearningregulationofcytochrome-coxidaseactivityregulationofmitochondrialtranslation
Serotonin N-acetyltransferase
8.6
65
43
SNATSNATQ29495Q29495cellularresponsetocAMPcircadianrhythmmelatoninbiosyntheticprocessN-terminalproteinaminoacidacetylation
Lysosome-associated membrane glycoprotein 1
2.0
51
87
LAMP1LAMP1P11438P11438autophagiccelldeathestablishmentofproteinlocalizationtoorganelleGolgitolysosometransportgranzyme-mediatedprogrammedcelldeathsignalingpathwaypositiveregulationofnaturalkillercelldegranulationpositiveregulationofnaturalkillercellmediatedcytotoxicityproteinstabilizationregulationoforganelletransportalongmicrotubulespermatogenesis
Anti-human Fc gamma receptor III 3G8 gamma heavy chain variable region
2.0
83
81
Q811U5Q811U5Q811U5Q811U5
Fermitin family homolog 1
8.9
45
48
FERM1FERM1P59113P59113basementmembraneorganizationcelladhesioncell-matrixadhesionestablishmentofepithelialcellpolarityintegrin-mediatedsignalingpathwaykeratinocytemigrationkeratinocyteproliferationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofgeneexpressionnegativeregulationofproteinimportintonucleusnegativeregulationofstemcellproliferationnegativeregulationoftimingofanagenpositiveregulationofcelladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofintegrinactivationpositiveregulationoftransforminggrowthfactorbetaproductionpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofwoundhealingspreadingofepidermalcells
Lipoyltransferase 1, mitochondrial
4.1
69
73
LIPTLIPTO46419O46419proteinlipoylation
Sulfotransferase 1E1
8.9
60
46
ST1E1ST1E1P49891P49891"3-phosphoadenosine5-phosphosulfatemetabolicprocess"estrogencatabolicprocessestrogenmetabolicprocessethanolcatabolicprocessfemalepregnancypositiveregulationoffatcelldifferentiationsulfation
Amphoterin-induced protein 1
2.0
47
87
AMGO1AMGO1Q80ZD8Q80ZD8axonalfasciculationaxonogenesisbraindevelopmentcelladhesioncellularresponsetoL-glutamateheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculeshomophiliccelladhesionviaplasmamembraneadhesionmoleculesmyelinationneuronprojectionfasciculationpositiveregulationofaxonogenesispositiveregulationofneuronprojectiondevelopmentpositiveregulationofpotassiumiontransmembranetransportpositiveregulationofsynapseassemblypositiveregulationofvoltage-gatedpotassiumchannelactivity
Angiopoietin-related protein 3
2.0
52
86
ANGL3ANGL3Q9Y5C1Q9Y5C1acylglycerolhomeostasisangiogenesisarterymorphogenesiscell-matrixadhesioncholesterolhomeostasischolesterolmetabolicprocessfattyacidmetabolicprocessglycerolmetabolicprocessintegrin-mediatedsignalingpathwaylipidhomeostasislipidstoragenegativeregulationoflipoproteinlipaseactivitynegativeregulationofphospholipaseactivityphospholipidcatabolicprocessphospholipidhomeostasisphospholipidmetabolicprocesspositiveregulationofangiogenesispositiveregulationofcellmigrationpositiveregulationoflipidcatabolicprocessresponsetohormonesignaltransductiontriglyceridehomeostasis
Leptin
2.0
nan
90
LEPLEPP41159P41159activationofproteinkinaseCactivityadiposetissuedevelopmentadultfeedingbehaviorangiogenesisaortadevelopmentbileacidmetabolicprocessbonegrowthbonemineralizationinvolvedinbonematurationcardiacmusclehypertrophycellularresponsetoinsulinstimuluscellularresponsetoL-ascorbicacidcellularresponsetoleptinstimuluscellularresponsetoretinoicacidcentralnervoussystemneurondevelopmentcholesterolmetabolicprocesscircadianrhythmdeterminationofadultlifespaneatingbehaviorelastinmetabolicprocessenergyreservemetabolicprocessfattyacidbeta-oxidationfemalepregnancyglucosehomeostasisglucosemetabolicprocessglycerolbiosyntheticprocesshormonemetabolicprocessinsulinsecretionintestinalabsorptionintracellularsignaltransductionleptin-mediatedsignalingpathwayleukocytetetheringorrollinglipidmetabolicprocessnegativeregulationofapoptoticprocessnegativeregulationofappetitenegativeregulationofappetitebyleptin-mediatedsignalingpathwaynegativeregulationofautophagynegativeregulationofcartilagedevelopmentnegativeregulationofglucagonsecretionnegativeregulationofglucoseimportnegativeregulationofglutaminetransportnegativeregulationoflipidstoragenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvasoconstrictionovulationfromovarianfolliclephagocytosisplacentadevelopmentpositiveregulationofcold-inducedthermogenesispositiveregulationofdevelopmentalgrowthpositiveregulationoffatcellapoptoticprocesspositiveregulationoffollicle-stimulatinghormonesecretionpositiveregulationofhepaticstellatecellactivationpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofiontransportpositiveregulationofluteinizinghormonesecretionpositiveregulationofMAPKcascadepositiveregulationofp38MAPKcascadepositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinimportintonucleuspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocesspositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofTcellproliferationpositiveregulationofTORsignalingpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftyrosinephosphorylationofSTATproteinprostaglandinsecretionregulationofangiogenesisregulationofbloodpressureregulationofboneremodelingregulationofbrownfatcelldifferentiationregulationofcellcycleregulationofcytokineproductioninvolvedininflammatoryresponseregulationofendothelialcellproliferationregulationofgluconeogenesisregulationofinsulinsecretionregulationofintestinalcholesterolabsorptionregulationoflipoproteinlipidoxidationregulationofnaturalkillercellactivationregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellproliferationregulationofnitric-oxidesynthaseactivityregulationofsteroidbiosyntheticprocessresponsetoactivityresponsetodietaryexcessresponsetoestradiolresponsetoethanolresponsetohypoxiaresponsetoinsulinresponsetovitaminEsexualreproductionTcelldifferentiationtyrosinephosphorylationofSTATprotein
HLA class II histocompatibility antigen, DQ beta 1 chain
2.0
83
80
DQB1DQB1P01920P01920adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIhumoralimmuneresponseimmuneresponsepeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationTcellreceptorsignalingpathway
Transmembrane emp24 domain-containing protein 5
2.0
50
85
TMED5TMED5Q9CXE7Q9CXE7endoplasmicreticulumtoGolgivesicle-mediatedtransportGolgiorganizationGolgiribbonformationintracellularproteintransport
Chondroitin sulfate proteoglycan 4
2.0
44
89
CSPG4CSPG4Q6UVK1Q6UVK1angiogenesisglialcellmigrationintracellularsignaltransductionplatelet-derivedgrowthfactorreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofpeptidyl-tyrosinephosphorylationruffleassemblysubstrate-dependentcellmigrationtissueremodeling
Sialic acid-binding Ig-like lectin 8
2.0
68
83
SIGL8SIGL8Q9NYZ4Q9NYZ4celladhesionsignaltransduction
Myelin protein P0
2.0
78
82
MYP0MYP0P25189P25189cellaggregationcell-celladhesionviaplasma-membraneadhesionmoleculeschemicalsynaptictransmissionmyelinationnegativeregulationofapoptoticprocess
Double C2-like domain-containing protein beta
2.0
74
78
DOC2BDOC2BP70610P70610calciumion-regulatedexocytosisofneurotransmittercalcium-dependentactivationofsynapticvesiclefusionexocytosispositiveregulationofcalciumion-dependentexocytosispositiveregulationofinsulinsecretionpositiveregulationofvesiclefusionproteinlocalizationregulationofcalciumion-dependentexocytosisspontaneousneurotransmittersecretion
Plasma protease C1 inhibitor
2.0
49
87
IC1IC1P05155P05155agingbloodcirculationbloodcoagulationcomplementactivationclassicalpathwayfibrinolysisinnateimmuneresponsenegativeregulationofcomplementactivationlectinpathwaynegativeregulationofendopeptidaseactivity
Programmed cell death 1 ligand 2
2.0
57
88
PD1L2PD1L2Q9WUL5Q9WUL5adaptiveimmuneresponsecellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharideimmuneresponsenegativeregulationofactivatedTcellproliferationnegativeregulationofinterleukin-10productionnegativeregulationofTcellproliferationnegativeregulationoftypeIIinterferonproductionpositiveregulationofTcellproliferationTcellcostimulation
Agouti-signaling protein
2.1
nan
89
ASIPASIPP42127P42127adultfeedingbehaviorcell-cellsignalinggenerationofprecursormetabolitesandenergygenomicimprintinghormone-mediatedsignalingpathwaymelaninbiosyntheticprocessmelanosomeorganizationmelanosometransportpositiveregulationofmelaninbiosyntheticprocesssignaltransduction
Glycosylated lysosomal membrane protein
2.2
70
80
GLMPGLMPQ9JHJ3Q9JHJ3positiveregulationoftranscriptionbyRNApolymeraseIIproteinlocalizationtolysosomeproteinstabilization
E3 ubiquitin-protein ligase RNF169
3.2
58
82
RN169RN169Q8NCN4Q8NCN4cellularresponsetoDNAdamagestimulusdouble-strandbreakrepairnegativeregulationofdouble-strandbreakrepair
Potassium voltage-gated channel subfamily C member 4
3.4
18
85
KCNC4KCNC4Q03721Q03721chemicalsynaptictransmissionpotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofiontransmembranetransport
Hsc70-interacting protein
3.6
74
76
F10A1F10A1P50503P50503chaperonecofactor-dependentproteinrefoldingnegativeregulationofproteinrefoldingresponsetobacterium
Zinc finger protein 496
3.7
37
87
ZN496ZN496Q5SXI5Q5SXI5positiveregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Eukaryotic translation initiation factor 2 subunit 1
3.8
66
70
IF2AIF2AP05198P05198agingcellularresponsetoaminoacidstarvationcellularresponsetoheatcellularresponsetooxidativestresscellularresponsetoUVnegativeregulationofguanyl-nucleotideexchangefactoractivitynegativeregulationoftranslationalinitiationinresponsetostressPERK-mediatedunfoldedproteinresponsepositiveregulationofneurondeathpositiveregulationoftypeBpancreaticcellapoptoticprocessproteinautophosphorylationregulationoftranslationalinitiationinresponsetostressresponsetoendoplasmicreticulumstressresponsetomanganese-inducedendoplasmicreticulumstressstressgranuleassembly
GA-binding protein alpha chain
4.0
51
72
✔
GABPAGABP1Q00422Q00420blastocystformationcelldifferentiationcellularresponsetodopamineinuteroembryonicdevelopmentnegativeregulationofmegakaryocytedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIImitochondrionorganization
RNA helicase
4.1
60
76
A7LCX1A7LCX1A7LCX1A7LCX1innateimmuneresponse
Protein regulator of cytokinesis 1
4.3
nan
80
✔
PRC1PRC1O43663O43663celldivisionmicrotubulecytoskeletonorganizationmitoticspindleelongationmitoticspindlemidzoneassemblypositiveregulationofcellpopulationproliferationregulationofcytokinesis
Endothelial protein C receptor
4.6
67
69
EPCREPCRQ9UNN8Q9UNN8bloodcoagulationnegativeregulationofcoagulation
ATP-dependent RNA helicase A
4.7
46
72
DHX9DHX9Q08211Q08211alternativemRNAsplicingviaspliceosomecellularresponsetoexogenousdsRNAcellularresponsetotumornecrosisfactorCRD-mediatedmRNAstabilizationDNAduplexunwindingDNAreplicationDNA-templatedtranscriptionterminationDNA-templatedviraltranscriptionG-quadruplexDNAunwindingglobalgenesilencingbymRNAcleavageinflammatoryresponseinnateimmuneresponsemRNAtransportnegativeregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecayosteoblastdifferentiationpositiveregulationofcytoplasmictranslationpositiveregulationofDNArepairpositiveregulationofDNAreplicationpositiveregulationofDNAtopoisomerase(ATP-hydrolyzing)activitypositiveregulationoffibroblastproliferationpositiveregulationofinflammatoryresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-18productionpositiveregulationofinterleukin-6productionpositiveregulationofmiRNA-mediatedgenesilencingpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpolysomebindingpositiveregulationofresponsetocytokinestimuluspositiveregulationofRNAexportfromnucleuspositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationofviraltranscriptionpositiveregulationofviraltranslationproteinlocalizationtocytoplasmicstressgranuleprotein-containingcomplexassemblypyroptosisregulationofcytoplasmictranslationregulationofdefenseresponsetovirusbyhostregulationofmRNAprocessingregulationoftranscriptionbyRNApolymeraseIIrhythmicprocessRISCcomplexassemblyRNAsecondarystructureunwinding
NACHT, LRR and PYD domains-containing protein 9
2.0
79
83
NLRP9NLRP9Q288C4Q288C4inflammatoryresponseinnateimmuneresponse
Serine/threonine-protein kinase PLK4
5.2
85
50
PLK4PLK4O00444O00444centriolereplicationciliumassemblydenovocentrioleassemblyinvolvedinmulti-ciliatedepithelialcelldifferentiationmitoticcellcyclepositiveregulationofcentriolereplicationproteinphosphorylationregulationofcytokinesistrophoblastgiantcelldifferentiation
Aspartoacylase
6.1
nan
72
ACY2ACY2P45381P45381aspartatecatabolicprocesscentralnervoussystemmyelinationpositiveregulationofoligodendrocytedifferentiation
Protein DBF4 homolog A
3.9
53
92
DBF4ADBF4AQ9UBU7Q9UBU7DNAreplicationG1/StransitionofmitoticcellcyclepositiveregulationofnuclearcellcycleDNAreplicationregulationofcellcyclephasetransition
MAP/microtubule affinity-regulating kinase 3
2.0
70
79
MARK3MARK3P27448P27448intracellularsignaltransductionmicrotubulecytoskeletonorganizationnegativeregulationofhipposignalingpeptidyl-serineautophosphorylationpeptidyl-serinephosphorylationpositiveregulationofproteinbindingproteinphosphorylation
Cellular retinoic acid-binding protein 1
7.2
63
52
RABP1RABP1P62964P62964fattyacidtransport
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
7.6
57
52
NHRF1NHRF1O14745O14745actincytoskeletonorganizationadenylatecyclase-activatingdopaminereceptorsignalingpathwayauditoryreceptorcellstereociliumorganizationbileacidsecretioncellularphosphateionhomeostasiscerebrospinalfluidcirculationciliumorganizationestablishmentofepithelialcellapical/basalpolarityestablishmentofGolgilocalizationfibroblastmigrationgamma-aminobutyricacidimportglandmorphogenesisglutathionetransportimportacrossplasmamembranemaintenanceofepithelialcellapical/basalpolaritymicrovillusassemblymorphogenesisofanepitheliumnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofcellpopulationproliferationnegativeregulationofERK1andERK2cascadenegativeregulationoffibroblastmigrationnegativeregulationofmitoticcellcyclenegativeregulationofphosphatidylinositol3-kinasesignalingnegativeregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaynegativeregulationofproteinkinaseBsignalingnegativeregulationofsodiumnuclearmigrationphospholipaseC-activatingdopaminereceptorsignalingpathwayplasmamembraneorganizationpositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofiontransmembranetransportproteinlocalizationtoplasmamembraneprotein-containingcomplexassemblyregulationofcellshaperegulationofcellsizeregulationofproteinkinaseactivityregulationofrenalphosphateexcretionregulationofsodiumrenalabsorptionrenalphosphateionabsorptionrenalsodiumiontransportsensoryperceptionofsoundtransportacrossblood-brainbarrierWntsignalingpathway
GTP-binding protein SAR1a
7.7
79
39
✔
SAR1ASAR1AQ9NR31Q9NR31COPII-coatedvesiclecargoloadingendoplasmicreticulumtoGolgivesicle-mediatedtransportintracellularproteintransportmembraneorganizationpositiveregulationofproteinexitfromendoplasmicreticulumregulationofCOPIIvesiclecoatingvesicleorganization
Enoyl-CoA hydratase domain-containing protein 3, mitochondrial
7.9
101
35
ECHD3ECHD3Q96DC8Q96DC8fattyacidmetabolicprocesspositiveregulationofcellularresponsetoinsulinstimulus
protein-serine/threonine phosphatase
7.9
85
34
A0A1S2ZIN9A0A1S2ZIN9A0A1S2ZIN9A0A1S2ZIN9
ATP-binding cassette sub-family C member 6
8.1
65
48
MRP6MRP6O95255O95255ATPmetabolicprocessATPtransportcalciumionhomeostasiscellularphosphateionhomeostasisgeneexpressioninorganicdiphosphatetransportleukotrienetransportphosphateionhomeostasisresponsetomagnesiumionresponsetosodiumphosphateresponsetoxenobioticstimulustransmembranetransportvisualperception
Golgi-associated plant pathogenesis-related protein 1
8.1
57
53
✔
GAPR1GAPR1Q9H4G4Q9H4G4positiveregulationofepithelialcellmigrationpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofERK1andERK2cascade
Insulin-like growth factor-binding protein 1
2.0
nan
87
IBP1IBP1P08833P08833insulinreceptorsignalingpathwaymulticellularorganismagingnegativeregulationofcanonicalWntsignalingpathwaypositiveregulationofcellgrowthregulationofinsulin-likegrowthfactorreceptorsignalingpathwayresponsetoorganiccycliccompoundsignaltransductiontissueregeneration
DCN1-like protein 4
8.4
60
46
DCNL4DCNL4Q92564Q92564positiveregulationofproteinneddylationpositiveregulationofubiquitin-proteintransferaseactivityproteinneddylation
Elongator complex protein 2
4.5
52
73
ELP2ELP2Q91WG4Q91WG4proteasomeassemblyregulationofreceptorsignalingpathwayviaJAK-STATtranscriptionelongationbyRNApolymeraseIIpromotertRNAwobbleuridinemodification
Glycine N-methyltransferase
8.5
77
39
GNMTGNMTQ9QXF8Q9QXF8glycinemetabolicprocessglycogenmetabolicprocessmethioninemetabolicprocessmethylationone-carbonmetabolicprocessproteinhomotetramerizationregulationofgluconeogenesisS-adenosylhomocysteinemetabolicprocessS-adenosylmethioninemetabolicprocesssarcosinemetabolicprocess
cAMP-dependent protein kinase type II-beta regulatory subunit
4.8
67
68
A1L1M0KAP3A1L1M0P31324proteinphosphorylationfattyacidmetabolicprocesslearningmodulationofchemicalsynaptictransmissionnegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivityresponsetoantipsychoticdrugresponsetoclozapine
Period circadian protein homolog 2
3.3
74
88
CRY1PER2P97784O54943circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodgluconeogenesisglucosehomeostasislipidstoragenegativeregulationofcircadianrhythmnegativeregulationofDNA-templatedtranscriptionnegativeregulationofGprotein-coupledreceptorsignalingpathwaynegativeregulationofglucocorticoidreceptorsignalingpathwaynegativeregulationofglucocorticoidsecretionnegativeregulationofgluconeogenesisnegativeregulationofproteinubiquitinationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgluconeogenesispositiveregulationofproteinubiquitinationregulationofcircadianrhythmregulationofDNAdamagecheckpointregulationofgluconeogenesisresponsetoactivityresponsetoglucagonresponsetoinsulinresponsetolightstimulusselectiveautophagysignaltransductioninresponsetoDNAdamagecircadianregulationoftranslationfattyacidmetabolicprocessglycogenbiosyntheticprocesshistoneH3deacetylationlactatebiosyntheticprocessnegativeregulationoffatcellproliferationnegativeregulationofterminationofDNA-templatedtranscriptionnegativeregulationoftranscriptionregulatoryregionDNAbindingpositiveregulationofcold-inducedthermogenesisregulationofcellcycleregulationofglutamateuptakeinvolvedintransmissionofnerveimpulseregulationofinsulinsecretionregulationofneurogenesisregulationofvasoconstrictionresponsetoischemiawhitefatcelldifferentiation
PIH1 domain-containing protein 1
8.7
75
34
PIHD1PIHD1Q9NWS0Q9NWS0boxC/DsnoRNPassemblychromatinremodelingepithelialcelldifferentiationestablishmentofproteinlocalizationtochromatinnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwaynegativeregulationofhistoneH3-K9dimethylationnegativeregulationofhistoneH3-K9trimethylationnegativeregulationofhistoneH4-K16acetylationpositiveregulationofglucosemediatedsignalingpathwaypositiveregulationofhistoneH3-K9acetylationpositiveregulationofhistoneH4acetylationpositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofprotein-containingcomplexassemblypositiveregulationofTORC1signalingpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseIproteinstabilizationregulationofhistoneH3-K4methylationrRNAprocessingsnoRNAlocalizationTORC1complexassembly
Acetyl-CoA acetyltransferase, cytosolic
9.0
77
31
✔
THICTHICQ9BWD1Q9BWD1fattyacidbeta-oxidationlipidmetabolicprocess
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase
9.0
76
38
LHPPLHPPQ9H008Q9H008dephosphorylationphosphate-containingcompoundmetabolicprocess
Vacuolar protein sorting-associated protein 54
9.1
70
33
VPS54VPS54Q5SPW0Q5SPW0apoptoticDNAfragmentationastrocytedifferentiationcellularcalciumionhomeostasiscellularresponsetoprogesteronestimulusgeneexpressionGolgitovacuoletransporthomeostasisofnumberofcellshomeostasisofnumberofcellswithinatissueinuteroembryonicdevelopmentL-glutamateimportlimbdevelopmentlimbmorphogenesislysosomaltransportmicrogliadifferentiationmitochondrionorganizationmotorbehaviormotorneuronapoptoticprocessmusculoskeletalmovementnegativeregulationofmotorneuronapoptoticprocessneuraltissueregenerationneurofilamentcytoskeletonorganizationneuroinflammatoryresponseneuromuscularsynaptictransmissionneuronapoptoticprocessneurondeathneuronprojectionmorphogenesispost-embryonicforelimbmorphogenesisproteinlocalizationproteinlocalizationtocellsurfaceproteintargetingtoERproteintargetingtolysosomeproteintargetingtovacuoleregulationofgrowthrespiratoryelectrontransportchainresponsetoantibioticresponsetocalciumionretrogradetransportendosometoGolgiskeletalmuscletissuedevelopmentskeletalmuscletissuegrowthspermatiddifferentiationsphingolipidcatabolicprocessstriatedmusclecontractionsynaptictransmissionGABAergicsynaptictransmissionglutamatergicthrombin-activatedreceptorsignalingpathwayubiquitinrecyclingvacuoleorganizationvesicle-mediatedcholesteroltransport
39S ribosomal protein L45, mitochondrial
9.1
70
32
RM45RM45Q9BRJ2Q9BRJ2mitochondrialtranslation
Histone-lysine N-methyltransferase SETD7
3.6
74
71
SETD7SETD7Q8WTS6Q8WTS6cellularresponsetoDNAdamagestimuluschromatinorganizationheterochromatinorganizationhistonelysinemethylationpeptidyl-lysinedimethylationpeptidyl-lysinemonomethylationregulationofDNA-templatedtranscriptionregulationofhistoneH3-K9methylation
Huntingtin-interacting protein 1-related protein
9.7
78
32
HIP1RHIP1RO75146O75146actinfilamentorganizationactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessclathrincoatassemblydigestivesystemdevelopmentendocytosisnegativeregulationofactinfilamentpolymerizationnegativeregulationofapoptoticprocessnegativeregulationofArp2/3complex-mediatedactinnucleationpositiveregulationofapoptoticprocesspositiveregulationofclathrincoatassemblypositiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofmitochondrialoutermembranepermeabilizationinvolvedinapoptoticsignalingpathwaypositiveregulationofplatelet-derivedgrowthfactorreceptor-betasignalingpathwaypositiveregulationofproteinbindingpostsynapseorganizationproteinstabilizationreceptor-mediatedendocytosisregulationofactincytoskeletonorganizationregulationofclathrin-dependentendocytosisregulationofendocytosisregulationofgastricacidsecretion
Aurora kinase C
9.7
72
32
AURKCAURKCQ9UQB9Q9UQB9attachmentofspindlemicrotubulestokinetochorecelldivisionhistonemodificationmeioticcellcyclemitoticspindlemidzoneassemblymitoticspindleorganizationpositiveregulationofcytokinesisproteinphosphorylationregulationofcytokinesis
Tripartite motif-containing protein 16-like protein
9.7
58
39
TR16LTR16LQ309B1Q309B1
Mitotic checkpoint serine/threonine-protein kinase BUB1
7.3
66
47
BUB1BUB1O43683O43683apoptoticprocesscelldivisioncellpopulationproliferationmeioticsisterchromatidcohesioncentromericmitoticspindleassemblycheckpointsignalingproteinphosphorylationregulationofchromosomesegregationregulationofsisterchromatidcohesion
Ras-related protein Rab-38
9.8
58
36
RAB38RAB38P57729P57729endosometomelanosometransportintracellularproteintransportmelanosomeassemblymelanosomeorganizationmitochondrionorganizationphagosomeacidificationplateletdensegranuleorganizationpositiveregulationofmelaninbiosyntheticprocesspositiveregulationofphosphatidylcholinebiosyntheticprocesspositiveregulationofproteinlocalizationtocellperipheryproteinlocalizationtomembraneproteintransportsmallGTPasemediatedsignaltransductionvesicle-mediatedtransport
Cation channel sperm-associated auxiliary subunit beta
2.7
52
87
CTSRBCTSRBA2RTF1A2RTF1spermcapacitation
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
2.0
51
85
GCNT1GCNT1Q09324Q09324celladhesionmoleculeproductionglycoproteinbiosyntheticprocesskidneymorphogenesisleukocytetetheringorrollingO-glycanprocessingcore2positiveregulationofleukocytetetheringorrollingresponsetoinsulintissuemorphogenesis
Protein Dok-7
9.1
38
47
DOK7DOK7Q18PE0Q18PE0neuromuscularjunctiondevelopmentpositiveregulationofproteinphosphorylationpositiveregulationofproteintyrosinekinaseactivityproteinphosphorylationreceptorclustering
NADPH:adrenodoxin oxidoreductase, mitochondrial
8.8
60
47
ADROADROP08165P08165cholesterolmetabolicprocesselectrontransportchainsteroidbiosyntheticprocessubiquinonebiosyntheticprocess
Cytochrome c1, heme protein, mitochondrial
8.9
69
40
CY1CY1P00125P00125mitochondrialelectrontransportubiquinoltocytochromec
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
2.0
49
88
SIA4ASIA4AQ02745Q02745lipidmetabolicprocessN-acetylneuraminatemetabolicprocessproteinN-linkedglycosylationsialylation
Phosphatidylinositide phosphatase SAC2
2.0
55
82
SAC2SAC2Q9Y2H2Q9Y2H2adultlocomotorybehaviorcardiacmusclehypertrophyinresponsetostressclathrin-dependentendocytosisnegativeregulationofaxonregenerationnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationoftyrosinephosphorylationofSTATproteinphosphatidylinositolbiosyntheticprocessphosphatidylinositolcatabolicprocessphosphatidylinositoldephosphorylationphosphatidylinositol-mediatedsignalingpositiveregulationofreceptorrecyclingregulationofcellmotilityregulationofendocyticrecyclingregulationofproteinkinaseBsignaling
Macrophage receptor MARCO
2.0
54
89
MARCOMARCOQ60754Q60754adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayamyloid-betaclearanceapoptoticcellclearanceendocytosisinnateimmuneresponsephagocytosisengulfmentpositiveregulationofERK1andERK2cascadepositiveregulationofproteinphosphorylationreceptor-mediatedendocytosis
EKC/KEOPS complex subunit TPRKB
2.0
63
80
TPRKBTPRKBQ9Y3C4Q9Y3C4tRNAthreonylcarbamoyladenosinemodification
Ryanodine receptor 3
2.0
62
81
RYR3RYR3Q15413Q15413calciumiontransmembranetransportcalciumiontransportcellularcalciumionhomeostasiscellularresponsetoATPcellularresponsetocaffeinecellularresponsetocalciumioncellularresponsetomagnesiumionproteinhomotetramerizationreleaseofsequesteredcalciumionintocytosol
Protocadherin alpha-4
2.0
52
86
PCDA4PCDA4O88689O88689celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
Heat shock factor 2-binding protein
2.0
62
81
HSF2BHSF2BO75031O75031double-strandbreakrepairinvolvedinmeioticrecombinationfemalemeiosisImalemeiosisIspermatogenesistranscriptionbyRNApolymeraseII
Protein Aster-A
2.0
44
85
ASTRAASTRAQ8VEF1Q8VEF1autophagycellularresponsetocholesterolintracellularsteroltransport
Immunoglobulin lambda variable 6-57
2.0
89
80
LV657LV657P06317P06317adaptiveimmuneresponseimmuneresponse
TRA@ protein
2.1
70
80
Q2YD82K7N5M4Q2YD82K7N5M4
Nuclear receptor subfamily 1 group I member 3
2.8
71
81
NR1I3NR1I3O35627O35627celldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscription
Peroxynitrite isomerase THAP4
3.4
86
69
THAP4THAP4Q8WY91Q8WY91nitratemetabolicprocesstyrosinemetabolicprocess
CASP8-associated protein 2
3.4
45
82
C8AP2C8AP2Q9UKL3Q9UKL3activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticsignalingpathwaycellcyclecellularresponsetomechanicalstimulusextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsFassignalingpathwaysignaltransduction
TOM1-like protein 1
4.8
nan
86
TM1L1TM1L1Q8N749Q8N749activationofproteinkinaseactivitynegativeregulationofmitoticnucleardivisionpositiveregulationofproteinautophosphorylationproteintransportsignaltransductionubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
RNA binding motif protein 5 isoform 1
3.9
33
90
A0A0S2Z549A0A0S2Z549A0A0S2Z549A0A0S2Z549mRNAprocessingRNAsplicing
Krueppel-like factor 3
3.8
38
87
KLF3KLF3Q60980Q60980cellularresponsetopeptidenegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Geminin coiled-coil domain-containing protein 1
3.8
42
81
GEMC1GEMC1A6NCL1A6NCL1cellcycleciliumassemblyDNAreplicationnegativeregulationofcellcyclenegativeregulationofDNAreplication
Golgin-45
3.7
78
71
GORS2GO45Q99JX3Q8R2X8celldifferentiationestablishmentofproteinlocalizationtoplasmamembraneGolgiorganizationorganelleassemblyorganelleorganizationresponsetoendoplasmicreticulumstressspermatogenesisGolgitoplasmamembraneproteintransport
NAD kinase
4.3
83
63
NADKNADKO95544O95544ATPmetabolicprocessNADmetabolicprocessNADPbiosyntheticprocessphosphorylation
Bone marrow stromal antigen 2
4.5
48
75
BST2BST2Q10589Q10589BcellactivationdefenseresponsetovirusinnateimmuneresponsenegativeregulationofcellgrowthnegativeregulationofcellmigrationnegativeregulationofintracellulartransportofviralmaterialnegativeregulationofplasmacytoiddendriticcellcytokineproductionnegativeregulationofviralgenomereplicationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteproliferationregulationofactincytoskeletonorganizationresponsetointerferon-alpharesponsetointerferon-betaresponsetotypeIIinterferonresponsetovirus
Meiosis regulator and mRNA stability factor 1
4.6
nan
69
MARF1MARF1Q9Y4F3Q9Y4F3double-strandbreakrepairfemalemeioticnucleardivisionoogenesisregulationofgeneexpression
Protein bicaudal D homolog 1
4.8
46
72
BICD1BICD1Q8BR07Q8BR07microtubuleanchoringatmicrotubuleorganizingcenterminus-end-directedorganelletransportalongmicrotubulenegativeregulationofphospholipaseCactivitynegativeregulationofphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocentrosomepositiveregulationofreceptor-mediatedendocytosisproteinlocalizationtoorganelleregulationofmicrotubulecytoskeletonorganizationregulationofproteinaseactivatedreceptoractivitystressgranuleassemblyviralprocess
cAMP-dependent protein kinase
4.8
67
68
A1L1M0KAP3A1L1M0P31324proteinphosphorylationfattyacidmetabolicprocesslearningmodulationofchemicalsynaptictransmissionnegativeregulationofcAMP-dependentproteinkinaseactivityregulationofproteinkinaseactivityresponsetoantipsychoticdrugresponsetoclozapine
Rootletin
5.1
nan
80
CROCCCROCCQ5TZA2Q5TZA2cellularhomeostasiscentriole-centriolecohesioncentrosomecycleciliarybasalbodyorganizationepithelialstructuremaintenanceestablishmentoflocalizationincellestablishmentoforganellelocalizationphotoreceptorcellmaintenancepositiveregulationofciliumassemblypositiveregulationofproteinlocalizationtociliumproteinlocalizationproteinlocalizationtoorganelle
Glutaredoxin-like protein C5orf63 homolog
5.7
53
71
YD286YD286Q9CWB7Q9CWB7
Src kinase-associated phosphoprotein 2
5.9
70
58
SKAP2SKAP2Q3UND0Q3UND0Bcellactivationnegativeregulationofcellpopulationproliferation
Phosphoglycerate kinase 2
6.7
70
51
PGK2PGK2P09041P09041flagellatedspermmotilitygluconeogenesisglycolyticprocessphosphorylation
Ubiquitin thioesterase OTUB2
6.8
75
51
OTUB2OTUB2Q96DC9Q96DC9negativeregulationofdouble-strandbreakrepairnegativeregulationofhistoneH2AK63-linkedubiquitinationproteindeubiquitinationproteinK11-linkeddeubiquitinationproteinK48-linkeddeubiquitinationproteinK63-linkeddeubiquitination
RecQ-mediated genome instability protein 1
7.2
64
48
RMI1RMI1Q9H9A7Q9H9A7DNAreplicationdouble-strandbreakrepairviahomologousrecombinationglucosehomeostasismulticellularorganismgrowthreductionoffoodintakeinresponsetodietaryexcessresolutionofmeioticrecombinationintermediatesresolutionofrecombinationintermediatesresponsetoglucose
Ribonuclease H1
7.2
75
46
RNH1RNH1O60930O60930DNAreplicationremovalofRNAprimerRNAcatabolicprocessRNAphosphodiesterbondhydrolysisendonucleolytic
Gamma-interferon-inducible lysosomal thiol reductase
2.0
66
85
GILTGILTQ9ESY9Q9ESY9antigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIInegativeregulationoffibroblastproliferationproteinstabilization
Voltage-dependent calcium channel gamma-3 subunit
2.0
59
87
CCG3CCG3Q8VHX0Q8VHX0neurotransmitterreceptorinternalizationneurotransmitterreceptorlocalizationtopostsynapticspecializationmembraneneurotransmitterreceptortransportpostsynapticendosometolysosomepositiveregulationofAMPAreceptoractivitypositiveregulationofsynaptictransmissionglutamatergicpostsynapticneurotransmitterreceptordiffusiontrappingproteinlocalizationproteintargetingregulationofAMPAreceptoractivitytransmissionofnerveimpulse
Zinc finger protein ZFPM1
3.6
40
89
FOG1FOG1O35615O35615atrialseptummorphogenesisatrioventricularvalvemorphogenesiscardiacmuscletissuemorphogenesiscelldifferentiationdefinitiveerythrocytedifferentiationembryonichemopoiesiserythrocytedifferentiationgranulocytedifferentiationheartdevelopmenthomeostasisofnumberofcellsmegakaryocytedevelopmentmegakaryocytedifferentiationmitralvalveformationnegativeregulationoffatcelldifferentiationnegativeregulationofinterleukin-4productionnegativeregulationofmastcelldifferentiationnegativeregulationofproteinbindingnegativeregulationoftranscriptionbyRNApolymeraseIIoutflowtractmorphogenesisplateletformationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftypeIIinterferonproductionprimitiveerythrocytedifferentiationregulationofchemokineproductionregulationofdefinitiveerythrocytedifferentiationtricuspidvalveformationventricularseptummorphogenesis
Ubiquitin-conjugating enzyme E2 R1
8.4
79
43
UB2R1UB2R1P49427P49427cellularresponsetointerferon-betaDNAreplicationinitiationG1/StransitionofmitoticcellcyclenegativeregulationofcAMP-mediatedsignalingpositiveregulationofinclusionbodyassemblypositiveregulationofneuronapoptoticprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationproteinubiquitinationresponsetogrowthfactorubiquitin-dependentproteincatabolicprocess
Eukaryotic translation initiation factor 3 subunit K
9.0
nan
47
EIF3KEIF3KQ9UBQ5Q9UBQ5formationofcytoplasmictranslationinitiationcomplexregulationoftranslationalinitiationtranslationalinitiation
NAD kinase 2, mitochondrial
9.0
nan
50
NAKD2NAKD2Q4G0N4Q4G0N4NADmetabolicprocessNADPbiosyntheticprocessphosphorylation
SOSS complex subunit B1
9.0
nan
52
SOSB1SOSB1Q9BQ15Q9BQ15cellularresponsetoDNAdamagestimulusDNArepairdouble-strandbreakrepairviahomologousrecombinationestablishmentofproteinlocalizationtotelomeremitoticG2/Mtransitioncheckpointpositiveregulationoftelomerecappingresponsetoionizingradiation
Acyl-coenzyme A thioesterase 13
9.5
64
38
ACO13ACO13Q9NPJ3Q9NPJ3lipidmetabolicprocessnegativeregulationofcold-inducedthermogenesisproteinhomotetramerization
Claudin-15
2.0
46
87
CLD15CLD15Q9Z0S5Q9Z0S5bicellulartightjunctionassemblycalcium-independentcell-celladhesionviaplasmamembranecell-adhesionmoleculescelladhesioniontransport
Sialoadhesin
2.0
71
85
SNSNQ62230Q62230celladhesionclathrin-dependentendocytosisofvirusbyhostcellpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofTcellapoptoticprocess
Igh protein
2.0
85
80
Q6PF95Q6PF95Q6PF95Q6PF95
RNA-binding protein 15
2.0
71
79
RBM15RBM15Q96T37Q96T37branchinginvolvedinbloodvesselmorphogenesisdosagecompensationbyinactivationofXchromosomenegativeregulationofmyeloidcelldifferentiationplacentabloodvesseldevelopmentpositiveregulationoftranscriptionofNotchreceptortargetregulationofalternativemRNAsplicingviaspliceosomeregulationofmegakaryocytedifferentiationRNAmethylationspleendevelopmentthrombopoietin-mediatedsignalingpathwayventricularseptummorphogenesis
Peroxisomal acyl-coenzyme A oxidase 1
3.9
97
65
ACOX1ACOX1P07872P07872fattyacidbeta-oxidationusingacyl-CoAoxidasefattyacidcatabolicprocessfattyacidoxidationgenerationofprecursormetabolitesandenergyhydrogenperoxidebiosyntheticprocesslipidhomeostasislipidmetabolicprocessprostaglandinmetabolicprocessspermatogenesisverylong-chainfattyacidbeta-oxidationverylong-chainfattyacidmetabolicprocess
Rap1 GTPase-GDP dissociation stimulator 1
6.8
64
50
✔
GDS1RHOAP52306P61586angiotensin-activatedsignalingpathwayinvolvedinheartprocessCAAX-boxproteinmaturationcardiacmusclehypertrophymyosinfilamentassemblynegativeregulationofendoplasmicreticulumcalciumionconcentrationnegativeregulationofGTPaseactivitypositiveregulationofGTPaseactivitypositiveregulationofmitochondrialcalciumionconcentrationproteinlocalizationtonucleusregulationofERK5cascaderegulationofmatrixmetallopeptidasesecretionregulationofmitochondrionorganizationvascularassociatedsmoothmusclecontractionactincytoskeletonorganizationactincytoskeletonreorganizationactinfilamentorganizationalpha-betaTcelllineagecommitmentandrogenreceptorsignalingpathwayangiotensin-mediatedvasoconstrictioninvolvedinregulationofsystemicarterialbloodpressureaorticvalveformationapicaljunctionassemblyapolipoproteinA-I-mediatedsignalingpathwaybetaselectioncelljunctionassemblycellmigrationcell-matrixadhesioncellularresponsetochemokinecellularresponsetocytokinestimuluscellularresponsetolipopolysaccharidecerebralcortexcellmigrationcleavagefurrowformationcorticalcytoskeletonorganizationcytoplasmicmicrotubuleorganizationendothelialcellmigrationendothelialtubelumenextensionestablishmentofepithelialcellapical/basalpolarityestablishmentormaintenanceofcellpolarityforebrainradialglialcelldifferentiationGTPmetabolicprocesskidneydevelopmentmitoticcleavagefurrowformationmitoticspindleassemblymotorneuronapoptoticprocessnegativechemotaxisnegativeregulationofcellmigrationinvolvedinsproutingangiogenesisnegativeregulationofcellsizenegativeregulationofcell-substrateadhesionnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofintracellularsteroidhormonereceptorsignalingpathwaynegativeregulationofmotorneuronapoptoticprocessnegativeregulationofneurondifferentiationnegativeregulationofneuronprojectiondevelopmentnegativeregulationofoxidativephosphorylationnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofvascularassociatedsmoothmusclecellmigrationnegativeregulationofvascularassociatedsmoothmusclecellproliferationneuronmigrationneuronprojectionmorphogenesisodontogenesisossificationinvolvedinbonematurationpositiveregulationofactinfilamentpolymerizationpositiveregulationofalpha-betaTcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcytokinesispositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationoflipaseactivitypositiveregulationofneuronapoptoticprocesspositiveregulationofneurondifferentiationpositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofpodosomeassemblypositiveregulationofproteinserine/threoninekinaseactivitypositiveregulationofstressfiberassemblypositiveregulationofTcellmigrationpositiveregulationoftranslationpositiveregulationofvascularassociatedsmoothmusclecontractionregulationofactincytoskeletonorganizationregulationofcalciumiontransportregulationofcellmigrationregulationofcellshaperegulationofdendritedevelopmentregulationoffocaladhesionassemblyregulationofmicrotubulecytoskeletonorganizationregulationofmodificationofpostsynapticactincytoskeletonregulationofmodificationofpostsynapticstructureregulationofneuralprecursorcellproliferationregulationofosteoblastproliferationregulationofsystemicarterialbloodpressurebyendothelinregulationoftranscriptionbyRNApolymeraseIIresponsetoaminoacidresponsetoethanolresponsetoglucocorticoidresponsetoglucoseresponsetohypoxiaresponsetomechanicalstimulusresponsetoxenobioticstimulusRhoproteinsignaltransductionRoundaboutsignalingpathwayskeletalmusclesatellitecellmigrationskeletalmuscletissuedevelopmentstressfiberassemblystress-activatedproteinkinasesignalingcascadesubstantianigradevelopmentsubstrateadhesion-dependentcellspreadingtrabeculamorphogenesisWntsignalingpathwayplanarcellpolaritypathwaywoundhealingspreadingofcells
Gigaxonin
7.1
48
60
GANGANQ9H2C0Q9H2C0cytoskeletonorganizationproteinubiquitination
Dynamin-1-like protein
7.7
56
53
DNM1LDNM1LO00429O00429calciumiontransportdynaminfamilyproteinpolymerizationinvolvedinmitochondrialfissionendocytosisheartcontractionintracellulardistributionofmitochondrialocalizationmembranefusionmitochondrialfissionmitochondrialfragmentationinvolvedinapoptoticprocessmitochondrialmembranefissionmitochondrionmorphogenesismitochondrionorganizationmitocytosisnecroptoticprocessperoxisomefissionpositiveregulationofapoptoticprocesspositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofmitochondrialfissionpositiveregulationofneutrophilchemotaxispositiveregulationofproteinsecretionpositiveregulationofreleaseofcytochromecfrommitochondriaproteincomplexoligomerizationproteinlocalizationtomitochondrionprotein-containingcomplexassemblyregulationofATPmetabolicprocessregulationofautophagyofmitochondrionregulationofgeneexpressionregulationofmitochondrionorganizationregulationofperoxisomeorganizationregulationofubiquitinproteinligaseactivityreleaseofcytochromecfrommitochondriarhythmicprocess
Resistin
2.0
71
84
RETNRETNQ99P87Q99P87fatcelldifferentiationnegativeregulationoffeedingbehaviorpositiveregulationofcollagenmetabolicprocesspositiveregulationofprogesteronesecretionpositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsynaptictransmissionresponsetoinsulin
Serine protease inhibitor Kazal-type 4
2.1
52
86
ISK4ISK4P37109P37109
Meiotic recombination protein REC114
5.0
59
67
RE114RE114Q9CWH4Q9CWH4DNArecombinationmeioticcellcycle
Cation channel sperm-associated auxiliary subunit delta
2.0
58
88
CTSRDCTSRDE9Q9F6E9Q9F6flagellatedspermmotilityspermcapacitationspermatogenesis
B9-scFv
2.0
85
80
A2NN81A2NN81A2NN81A2NN81
Matrix metalloproteinase-23
2.0
nan
92
MMP23MMP23O88272O88272collagencatabolicprocessextracellularmatrixorganizationproteolysisreproduction
Rab-like protein 3
6.6
56
55
RABL3RABL3Q9D4V7Q9D4V7BcelldifferentiationintracellularproteintransportnaturalkillercelldifferentiationproteinstabilizationregulationofproteinlipidationregulationofRasproteinsignaltransductionTcelldifferentiationinthymus
Heparan sulfate glucosamine 3-O-sulfotransferase 5
2.0
55
83
HS3S5HS3S5Q8IZT8Q8IZT8heparansulfateproteoglycanbiosyntheticprocessenzymaticmodificationnegativeregulationofcoagulationproteinsulfationregulationofviralentryintohostcell
Blood group Rh(CE) polypeptide
5.4
nan
73
RHCERHCEP18577P18577ammoniumhomeostasisammoniumtransmembranetransport
GON-4-like protein
8.5
17
56
✔
GON4LGON4LQ9DB00Q9DB00BcelldifferentiationnegativeregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscription
Eukaryotic initiation factor 4A-I
9.5
74
35
✔
IF4A1IF4A1P60842P60842cytoplasmictranslationalinitiationtranslationalinitiation
Meteorin-like protein
2.0
40
84
METRLMETRLQ8VE43Q8VE43brownfatcelldifferentiationenergyhomeostasisfatcelldifferentiationnegativeregulationofinflammatoryresponsepositiveregulationofbrownfatcelldifferentiationresponsetocoldresponsetomuscleactivity
Anti-HCV NS3/4A serine protease immoglobulin heavy chain
2.0
90
79
A0A0F6YEF6A0A0F6YEF6A0A0F6YEF6A0A0F6YEF6proteolysis
AEP5A5
2.1
86
81
A0A4E0W6L3A0A4E0W6L3A0A4E0W6L3A0A4E0W6L3
Zinc transporter ZIP4
2.0
nan
90
L5KLU7L5KLU7L5KLU7L5KLU7
Scavenger receptor class B member 1
8.9
24
53
SCRB1SCRB1Q61009Q61009adhesionofsymbionttohostandrogenbiosyntheticprocessbloodvesselendothelialcellmigrationcarotenoidtransportcholesterolcatabolicprocesscholesteroleffluxcholesterolhomeostasischolesterolimportcholesteroltransportdetectionoflipopolysaccharideendothelialcellproliferationhigh-densitylipoproteinparticleclearancehigh-densitylipoproteinparticleremodelingintestinallipidabsorptionlipidtransportlipopolysaccharidetransportlow-densitylipoproteinparticleclearancephagocytosisrecognitionphospholipidtransportplasmalipoproteinparticleclearancepositiveregulationofcholesterolstoragepositiveregulationofnitric-oxidesynthaseactivitypositiveregulationoftriglyceridebiosyntheticprocessrecognitionofapoptoticcellregulationofphagocytosisregulationofphosphatidylcholinecatabolicprocessreversecholesteroltransporttriglyceridehomeostasisvitamintransmembranetransport
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
9.5
33
nan
CNRGCNRGP04972P04972positiveregulationofepidermalgrowthfactorreceptorsignalingpathwaypositiveregulationofGprotein-coupledreceptorsignalingpathwaypositiveregulationofMAPKcascaderesponsetostimulusvisualperception
Fc receptor-like A
2.0
82
83
FCRLAFCRLAQ7L513Q7L513celldifferentiationcellsurfacereceptorsignalingpathway
GTPase IMAP family member 1
4.4
70
70
GIMA1GIMA1Q8WWP7Q8WWP7
Protein phosphatase 1H
7.5
66
44
PPM1HPPM1HQ9ULR3Q9ULR3proteindephosphorylation
Fucose mutarotase
8.8
50
48
FUCMFUCMQ8R2K1Q8R2K1femalematingbehaviorfucosemetabolicprocessfucosylationnegativeregulationofneurondifferentiationneurondifferentiation
Interferon alpha-5
2.0
nan
88
IFNA5IFNA5P07349P07349adaptiveimmuneresponseBcelldifferentiationBcellproliferationcytokine-mediatedsignalingpathwaydefenseresponsetovirushumoralimmuneresponsenaturalkillercellactivationinvolvedinimmuneresponsepositiveregulationofpeptidyl-serinephosphorylationofSTATproteinresponsetoexogenousdsRNATcellactivationinvolvedinimmuneresponse
Kynurenine--oxoglutarate transaminase 3
5.1
82
57
KAT3KAT3Q71RI9Q71RI92-oxoglutaratemetabolicprocessaminoacidmetabolicprocessbiosyntheticprocesskynureninemetabolicprocessL-kynureninecatabolicprocess
Trefoil factor 2
2.0
52
87
TFF2TFF2P01359P01359chemokine-mediatedsignalingpathwaymaintenanceofgastrointestinalepitheliumnegativeregulationofgastricacidsecretion
Protocadherin beta-14
2.1
45
85
PCDBEPCDBEQ6PB90Q6PB90celladhesionhomophiliccelladhesionviaplasmamembraneadhesionmolecules
Plexin-B2
3.6
34
83
✔
PLXB2PLXB2B2RXS4B2RXS4braindevelopmentexcitatorysynapseassemblyhomophiliccelladhesionviaplasmamembraneadhesionmoleculesnegativeregulationofcelladhesionneuraltubeclosureneuroblastproliferationpositiveregulationofaxonogenesispositiveregulationofneuronprojectiondevelopmentpositiveregulationoftranslationregulationofcellmigrationregulationofcellshaperegulationofGTPaseactivityregulationofneuronmigrationregulationofproteinphosphorylationsemaphorin-plexinsignalingpathwaysemaphorin-plexinsignalingpathwayinvolvedinaxonguidance
Inositol polyphosphate 1-phosphatase
7.8
88
44
INPPINPPP21327P21327inositolphosphatedephosphorylationphosphatidylinositolphosphatebiosyntheticprocess
Breast cancer type 2 susceptibility protein homolog
9.1
75
47
✔
BRCA2BRCA2O35923O35923braindevelopmentcellpopulationproliferationcellularresponsetoDNAdamagestimuluscellularresponsetoionizingradiationcellularsenescencecentrosomeduplicationchordateembryonicdevelopmentchromosomeorganizationDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorDNArecombinationdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationestablishmentofproteinlocalizationtotelomerefemalegonaddevelopmenthematopoieticstemcellproliferationhemopoiesishistoneH3acetylationhistoneH4acetylationhomologouschromosomeorientationinvolvedinmeioticmetaphaseIplatecongressioninnercellmasscellproliferationintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatormalemeiosisImammaryglanddevelopmentmitoticrecombination-dependentreplicationforkprocessingmulticellularorganismgrowthnegativeregulationofmammaryglandepithelialcellproliferationnucleotide-excisionrepairoocytematurationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofmitoticcellcycleregulationofcytokinesisregulationofDNA-templatedtranscriptionreplicationforkprotectionresponsetoestradiolresponsetogammaradiationresponsetonutrientresponsetoUV-CresponsetoX-rayspermatogenesisstemcellproliferationtelomeremaintenanceviarecombination
Anti-CEA 79 single chain Fv
2.0
80
80
Q921A6Q921A6Q921A6Q921A6
Anti-F4+ETEC bacteria VHH variable region
2.0
84
79
R9VYW2R9VYW2R9VYW2R9VYW2
Ig-like domain-containing protein
2.1
88
79
A0A0G2JZW1A0A0G2JZW1A0A0G2JZW1A0A0G2JZW1
Mitochondrial dynamics protein MID49
7.0
70
45
MID49MID49Q5NCS9Q5NCS9dynaminfamilyproteinpolymerizationinvolvedinmitochondrialfissionmitochondrionorganizationpositiveregulationofmitochondrialfissionpositiveregulationofproteintargetingtomembraneregulationofmitochondrionorganization
Receptor-interacting serine/threonine-protein kinase 4
3.9
50
78
RIPK4RIPK4Q9ERK0Q9ERK0morphogenesisofanepitheliumpositiveregulationofNF-kappaBtranscriptionfactoractivityproteinphosphorylation
GTPase IMAP family member 4
2.0
60
86
GIMA4GIMA4Q9NUV9Q9NUV9
Mucin-like protocadherin
2.0
61
87
Q58EZ6Q58EZ6Q58EZ6Q58EZ6homophiliccelladhesionviaplasmamembraneadhesionmolecules
Interleukin-3
3.1
49
84
IL3IL3P08700P08700cell-cellsignalingembryonichemopoiesisimmuneresponsenervoussystemdevelopmentpositiveregulationofcellpopulationproliferationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationoftyrosinephosphorylationofSTATprotein
N-acetyltransferase ESCO2
3.8
53
85
ESCO2ESCO2Q8CIB9Q8CIB9chromosomesegregationdouble-strandbreakrepairhematopoieticprogenitorcelldifferentiationmitoticsisterchromatidcohesionpost-translationalproteinacetylationproteinlocalizationtochromatinregulationofDNAreplication
Caspase recruitment domain-containing protein 19
3.8
65
75
CAR19CAR19Q96LW7Q96LW7negativeregulationofI-kappaBkinase/NF-kappaBsignaling
Polyunsaturated fatty acid lipoxygenase ALOX15B
4.0
75
69
LX15BLX15BO15296O15296apoptoticprocessarachidonicacidmetabolicprocesscannabinoidbiosyntheticprocessendocannabinoidsignalingpathwayhepoxilinbiosyntheticprocesslinoleicacidmetabolicprocesslipidmetabolicprocesslipidoxidationlipoxinA4biosyntheticprocesslipoxygenasepathwaynegativeregulationofcellcyclenegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofgrowthphospholipidmetabolicprocesspositiveregulationofchemokineproductionpositiveregulationofkeratinocytedifferentiationpositiveregulationofmacrophagederivedfoamcelldifferentiationpositiveregulationofperoxisomeproliferatoractivatedreceptorsignalingpathwayprostateglanddevelopmentregulationofepithelialcelldifferentiation
Phosphomannomutase 1
5.0
77
62
PMM1PMM1Q92871Q92871cellularresponsetoleukemiainhibitoryfactorGDP-mannosebiosyntheticprocessmannosemetabolicprocessproteinN-linkedglycosylation
Transcription factor COE3
5.6
59
62
COE3COE3Q9H4W6Q9H4W6positiveregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseII
Diphosphomevalonate decarboxylase
5.7
93
50
MVD1MVD1Q99JF5Q99JF5cholesterolbiosyntheticprocessisopentenyldiphosphatebiosyntheticprocessmevalonatepathwayisoprenoidbiosyntheticprocesspositiveregulationofcellpopulationproliferation
Exosome complex component CSL4
6.4
72
55
EXOS1EXOS1Q9Y3B2Q9Y3B2RNAcatabolicprocessRNAprocessingrRNAprocessing
26S proteasome non-ATPase regulatory subunit 10
6.8
64
60
PSD10PSD10O75832O75832apoptoticprocesscytoplasmicsequesteringofNF-kappaBnegativeregulationofapoptoticprocessnegativeregulationofDNAdamageresponsesignaltransductionbyp53classmediatornegativeregulationofMAPKcascadenegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofreleaseofcytochromecfrommitochondrianegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellgrowthpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofproteinubiquitinationproteasomeregulatoryparticleassembly
Protein LTV1 homolog
7.5
53
53
LTV1LTV1Q96GA3Q96GA3ribosomalsmallsubunitbiogenesisribosomalsmallsubunitexportfromnucleus
Potassium voltage-gated channel subfamily A member 3
2.0
46
87
KCNA3KCNA3P22001P22001corpuscallosumdevelopmentopticnervedevelopmentpotassiumiontransmembranetransportpotassiumiontransportproteinhomooligomerizationregulationofiontransmembranetransport
Nuclear receptor coactivator 5
7.8
84
41
NCOA5NCOA5Q9HCD5Q9HCD5glucosehomeostasisinsulinreceptorsignalingpathwaynegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIregulationofsignaltransduction
SAM domain-containing protein SAMSN-1
8.0
43
53
SAMN1SAMN1Q9NSI8Q9NSI8negativeregulationofadaptiveimmuneresponsenegativeregulationofBcellactivationnegativeregulationofpeptidyl-tyrosinephosphorylation
RAS guanyl-releasing protein 2
9.5
54
42
GRP2GRP2Q7LDG7Q7LDG7cellularresponsetocalciumionpositiveregulationofGTPaseactivityRasproteinsignaltransductionregulationofcellgrowthsignaltransduction
Glutathione peroxidase 6
2.1
64
85
GPX6GPX6Q91WR8Q91WR8responsetooxidativestress
2-Hydroxyacid oxidase 2
4.0
94
65
HAOX2HAOX2Q07523Q07523fattyacidoxidationmandelatemetabolicprocess
B-lymphocyte antigen CD20
2.0
37
87
CD20CD20P11836P11836BcellactivationBcelldifferentiationBcellproliferationBcellreceptorsignalingpathwaycalciumionimportintocytosolcellsurfacereceptorsignalingpathwayhumoralimmuneresponsepositiveregulationofcalciumionimportacrossplasmamembraneproteintetramerizationresponsetobacteriumstore-operatedcalciumentry
Endophilin-A1
7.0
78
51
SH3G2SH3G2O35179O35179cellularresponsetobrain-derivedneurotrophicfactorstimulusdendriteextensionlipidtubeassemblymembranebendingmembranetubulationnegativeregulationofblood-brainbarrierpermeabilitynegativeregulationofgeneexpressionnegativeregulationofproteinphosphorylationneuronprojectiondevelopmentpositiveregulationofmembranetubulationpostsynapticactincytoskeletonorganizationregulationofclathrin-dependentendocytosisregulationofreceptorinternalizationsynapticvesicleendocytosissynapticvesicleuncoatingvesiclescission
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
3.3
68
77
NDUABNDUABQ8HXG6Q8HXG6mitochondrialrespiratorychaincomplexIassembly
Aurora kinase A
5.3
41
65
✔
AURKAAURKAO14965O14965anterior/posterioraxisspecificationapoptoticprocesscelldivisioncentrosomelocalizationciliumdisassemblyG2/Mtransitionofmitoticcellcycleliverregenerationmitoticcellcyclemitoticcentrosomeseparationmitoticspindleorganizationnegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofproteinbindingneuronprojectionextensionpeptidyl-serinephosphorylationpositiveregulationofmitochondrialfissionpositiveregulationofmitoticcellcyclepositiveregulationofmitoticnucleardivisionpositiveregulationofoocytematurationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinautophosphorylationproteinlocalizationtocentrosomeproteinphosphorylationregulationofcentrosomecycleregulationofcytokinesisregulationofG2/Mtransitionofmitoticcellcycleregulationofproteinstabilityregulationofsignaltransductionbyp53classmediatorresponsetowoundingspindleassemblyinvolvedinfemalemeiosisIspindleorganization
T-cell surface glycoprotein CD3 zeta chain
2.0
40
87
CD3ZCD3ZP20963P20963adaptiveimmuneresponsealpha-betaTcellactivationcellsurfacereceptorsignalingpathwayFc-gammareceptorsignalingpathwaygamma-deltaTcellactivationpositiveregulationofproteinlocalizationtocellsurfaceprotein-containingcomplexassemblyTcellreceptorsignalingpathway
7SK snRNA methylphosphate capping enzyme
2.0
80
83
✔
MEPCEMEPCEQ7L2J0Q7L2J0negativeregulationofchromatinbindingnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofG1/StransitionofmitoticcellcyclepositiveregulationofproteinlocalizationtoCajalbodypositiveregulationofsnRNAtranscriptionbyRNApolymeraseIIRNAmethylationsnRNAmetabolicprocesssnRNAmodification
Translationally-controlled tumor protein
2.1
50
88
TCTPTCTPP13693P13693calciumiontransportcellularcalciumionhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageregulationofapoptoticprocessresponsetovirus
Ubiquitin-associated protein 1
2.0
28
88
UBAP1UBAP1Q9NZ09Q9NZ09membranefissionmultivesicularbodyassemblyproteintransporttovacuoleinvolvedinubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathwayubiquitin-dependentproteincatabolicprocessviathemultivesicularbodysortingpathway
Endonuclease G, mitochondrial
2.0
71
80
NUCGNUCGO08600O08600agingapoptoticDNAfragmentationcellularresponsetocalciumioncellularresponsetoglucosestimuluscellularresponsetohypoxiaDNAcatabolicprocessinuteroembryonicdevelopmentmitochondrialDNAcatabolicprocessnegativeregulationofTORsignalingneurondeathinresponsetooxidativestresspositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofautophagypositiveregulationofhydrogenperoxide-mediatedprogrammedcelldeathpositiveregulationofmitochondrialDNAreplicationpositiveregulationofresponsetoDNAdamagestimulusresponsetoantibioticresponsetoestradiolresponsetomechanicalstimulusresponsetotumornecrosisfactor
T-box transcription factor TBX5
2.1
71
79
TBX5TBX5Q99593Q99593atrialseptummorphogenesisatrioventricularbundlecelldifferentiationatrioventricularnodecelldevelopmentatrioventricularnodecellfatecommitmentatrioventricularvalvemorphogenesisbundleofHiscelltoPurkinjemyocytecommunicationbyelectricalcouplingbundleofHisdevelopmentcardiacleftventricleformationcardiacmusclecellproliferationcellfatespecificationcellmigrationinvolvedincoronaryvasculogenesiscell-cellsignalingcell-cellsignalinginvolvedincardiacconductionembryonicforelimbmorphogenesisembryoniclimbmorphogenesisendocardialcushiondevelopmentforelimbmorphogenesisheartdevelopmentlungdevelopmentmorphogenesisofanepitheliumnegativeregulationofcardiacmusclecellproliferationnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofepithelialtomesenchymaltransitionpatternspecificationprocesspericardiumdevelopmentpositiveregulationofcardiacconductionpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcardioblastdifferentiationpositiveregulationofcellcommunicationbyelectricalcouplinginvolvedincardiacconductionpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgapjunctionassemblypositiveregulationofsecondaryheartfieldcardioblastproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofatrialcardiacmusclecellmembranedepolarizationregulationoftranscriptionbyRNApolymeraseIIsinoatrialnodedevelopmenttranscriptionbyRNApolymeraseIIventricularseptumdevelopment
Transient receptor potential cation channel subfamily V member 3
2.8
35
91
B2KYM6B2KYM6B2KYM6B2KYM6calciumiontransmembranetransport
LINE-1 type transposase domain-containing protein 1
3.5
57
82
LITD1LITD1Q5T7N2Q5T7N2transpositionRNA-mediated
Receptor-interacting serine/threonine-protein kinase 2
4.4
51
73
RIPK2RIPK2O43353O43353activationofcysteine-typeendopeptidaseactivityadaptiveimmuneresponseapoptoticprocessCD4-positivealpha-betaTcellproliferationcellularresponsetolipoteichoicacidcellularresponsetomuramyldipeptidecellularresponsetopeptidoglycancytokine-mediatedsignalingpathwaydefenseresponsetoGram-positivebacteriumERK1andERK2cascadeI-kappaBkinase/NF-kappaBsignalingimmatureTcellproliferationinthymusinflammatoryresponseinnateimmuneresponseJNKcascadelipopolysaccharide-mediatedsignalingpathwaynucleotide-bindingoligomerizationdomaincontaining1signalingpathwaynucleotide-bindingoligomerizationdomaincontaining2signalingpathwaypositiveregulationofapoptoticprocesspositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcelldeathpositiveregulationofchemokineproductionpositiveregulationofcytokine-mediatedsignalingpathwaypositiveregulationofERK1andERK2cascadepositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofimmatureTcellproliferationinthymuspositiveregulationofinterferon-alphaproductionpositiveregulationofinterferon-betaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-6productionpositiveregulationofJNKcascadepositiveregulationofmacrophagecytokineproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofpeptidyl-threoninephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinbindingpositiveregulationofproteinubiquitinationpositiveregulationofT-helper1celldifferentiationpositiveregulationofT-helper1typeimmuneresponsepositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationofxenophagyresponsetoexogenousdsRNAresponsetointerleukin-1responsetointerleukin-12responsetointerleukin-18signaltransductionTcellreceptorsignalingpathwaytoll-likereceptor2signalingpathwaytoll-likereceptor4signalingpathwayxenophagy
Matrix metalloproteinase-14
4.7
43
75
MMP14MMP14P50281P50281angiogenesisastrocytecellmigrationbranchingmorphogenesisofanepithelialtubecellmotilitychondrocyteproliferationcollagencatabolicprocesscraniofacialsuturemorphogenesisembryoniccranialskeletonmorphogenesisendochondralossificationendodermalcelldifferentiationendothelialcellproliferationextracellularmatrixdisassemblyextracellularmatrixorganizationheaddevelopmentlungdevelopmentmalegonaddevelopmentnegativeregulationoffocaladhesionassemblynegativeregulationofNotchsignalingpathwayovarianfollicledevelopmentpositiveregulationofBcelldifferentiationpositiveregulationofcellgrowthpositiveregulationofcellmigrationpositiveregulationofmacrophagemigrationpositiveregulationofmyotubedifferentiationpositiveregulationofproteinprocessingproteinprocessingproteolysisregulationofproteinlocalizationtoplasmamembraneresponsetoestrogenresponsetohypoxiaresponsetomechanicalstimulusresponsetoodorantresponsetoorganiccycliccompoundresponsetooxidativestressskeletalsystemdevelopmenttissueremodelingzymogenactivation
28S ribosomal protein S27, mitochondrial
5.7
59
60
RT27RT27Q32PI8Q32PI8cellpopulationproliferationpositiveregulationofmitochondrialtranslation
Serine/threonine-protein kinase 17A
6.1
55
63
ST17AST17AQ9UEE5Q9UEE5apoptoticprocessintracellularsignaltransductionpositiveregulationofapoptoticprocesspositiveregulationoffibroblastapoptoticprocessproteinphosphorylationregulationofreactiveoxygenspeciesmetabolicprocess
Bifunctional polynucleotide phosphatase/kinase
2.9
72
76
✔
PNKPPNKPQ9JLV6Q9JLV6cellularresponsetoDNAdamagestimulusDNAligationinvolvedinDNArepairDNArepairdouble-strandbreakrepairvianonhomologousendjoiningnegativeregulationofproteinADP-ribosylationnucleotidephosphorylationpositiveregulationofdouble-strandbreakrepairvianonhomologousendjoiningpositiveregulationoftelomeraseactivitypositiveregulationoftelomerecappingpositiveregulationoftelomeremaintenanceviatelomeraseproteinK63-linkedubiquitinationresponsetooxidativestress
Malectin
9.1
nan
55
MLECMLECQ14165Q14165carbohydratemetabolicprocessproteinN-linkedglycosylation
Peptidoglycan recognition protein 1
2.0
52
86
PGRP1PGRP1Q9GK12Q9GK12defenseresponsetobacteriuminnateimmuneresponsenegativeregulationofcytokineproductionpeptidoglycancatabolicprocess
Cell surface glycoprotein CD200 receptor 1
2.0
58
88
MO2R1MO2R1Q9ES57Q9ES57heterotypiccell-celladhesionnegativeregulationofinterleukin-6productionnegativeregulationofmacrophagemigrationnegativeregulationofneuroinflammatoryresponsenegativeregulationofneurondeathnegativeregulationofTcellmigrationregulationofneuroinflammatoryresponse
P2X purinoceptor 4
2.0
63
86
P2RX4P2RX4P51577P51577apoptoticsignalingpathwaybehavioralresponsetopaincalciumiontransmembranetransportcalciumiontransportcationtransmembranetransportcellularresponsetoATPcellularresponsetozincionexcitatorypostsynapticpotentialinorganiccationtransmembranetransportiontransmembranetransportmembranedepolarizationnegativeregulationofcardiacmusclehypertrophyneuronalactionpotentialnitricoxidebiosyntheticprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcalciumiontransportintocytosolpositiveregulationofcalcium-mediatedsignalingpositiveregulationofendothelialcellchemotaxispositiveregulationofmicroglialcellmigrationpositiveregulationofproteinkinaseBsignalingpurinergicnucleotidereceptorsignalingpathwayregulationofbloodpressureregulationofcardiacmusclecontractionregulationofchemotaxisregulationofsodiumiontransportrelaxationofcardiacmuscleresponsetoATPresponsetoaxoninjuryresponsetofluidshearstressresponsetoischemiasensoryperceptionofpainsensoryperceptionoftouchsignaltransductionvasodilation
Junctional adhesion molecule-like
2.0
78
81
JAMLJAMLQ80UL9Q80UL9gamma-deltaTcellactivationheterophiliccell-celladhesionviaplasmamembranecelladhesionmoleculesmonocyteextravasationneutrophilchemotaxisneutrophilextravasationpositiveregulationofepithelialcellproliferationinvolvedinwoundhealing
SH3-containing GRB2-like protein 3-interacting protein 1
6.4
nan
69
SGIP1SGIP1Q9BQI5Q9BQI5clathrincoatassemblyclathrin-dependentendocytosisenergyhomeostasispositiveregulationoffeedingbehaviorpositiveregulationofreceptor-mediatedendocytosisresponsetodietaryexcess
Cadherin-6
2.0
nan
86
CADH6CADH6P55285P55285adherensjunctionorganizationcalcium-dependentcell-celladhesionviaplasmamembranecelladhesionmoleculescelladhesioncellmorphogenesiscell-celladhesionviaplasma-membraneadhesionmoleculescell-celljunctionassemblyhomophiliccelladhesionviaplasmamembraneadhesionmoleculesNotchsignalingpathwaysynapticmembraneadhesion
F-box only protein 4
9.1
nan
49
✔
SKP1FBX4P63208Q9UKT5chromatinremodelingmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessagingcellularhomeostasiscellularresponsetoionizingradiationcommonmyeloidprogenitorcellproliferationnegativeregulationoffibroblastproliferationnegativeregulationofproteinlocalizationtonucleuspositiveregulationofproteinpolyubiquitinationpositiveregulationofproteinubiquitinationpositiveregulationoftelomeremaintenanceviatelomerasepost-transcriptionalregulationofgeneexpressionproteindestabilizationregulationofDNAdamagecheckpointregulationofproteinstabilitytelomeremaintenanceubiquitin-dependentproteincatabolicprocess
DNA replication factor Cdt1
9.1
42
49
✔
CDT1CDT1Q8R4E9Q8R4E9attachmentofmitoticspindlemicrotubulestokinetochorecelldivisionchromosomesegregationdeactivationofmitoticspindleassemblycheckpointDNAreplicationcheckpointsignalingDNAreplicationpreinitiationcomplexassemblykinetochoreorganizationmitoticcellcyclenegativeregulationofcellcyclenegativeregulationofDNA-templatedDNAreplicationnegativeregulationofproteinlocalizationtokinetochorepositiveregulationofchromatinbindingpositiveregulationofDNAreplicationpositiveregulationofDNA-templatedDNAreplicationpositiveregulationofproteinlocalizationtokinetochorepositiveregulationofprotein-containingcomplexassemblyregulationofchromosomeorganizationregulationofDNAreplicationoriginbindingregulationofDNA-templatedDNAreplicationinitiationregulationofnuclearcellcycleDNAreplicationresponsetosorbitol
Epididymal-specific lipocalin-12
2.0
nan
92
LCN12LCN12B3EY83B3EY83
G-rich sequence factor 1
2.0
nan
88
GRSF1GRSF1Q12849Q12849anterior/posteriorpatternspecificationmorphogenesisofembryonicepitheliummRNApolyadenylationpositiveregulationofmitochondrialRNAcatabolicprocessregulationofRNAsplicingtRNAprocessing
Cystatin-8
2.0
58
86
CST8CST8P32766P32766negativeregulationofpeptidaseactivity
Immunoglobulin heavy variable 3-33
2.0
33
87
IGLC1HV333P01842P01772adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Nesprin-4
2.4
nan
88
SYNE4SYNE4Q8N205Q8N205establishmentofepithelialcellapical/basalpolarity
Integrin beta-4
2.0
46
86
ITB4DYSTP16144Q03001autophagycelladhesioncelladhesionmediatedbyintegrincellmigrationcellmotilitycell-matrixadhesionfilopodiumassemblyhemidesmosomeassemblyintegrin-mediatedsignalingpathwaymesodermalcelldifferentiationnaildevelopmentperipheralnervoussystemmyelinformationresponsetowoundingskinmorphogenesistrophoblastcellmigrationcytoskeletonorganizationintermediatefilamentcytoskeletonorganizationmaintenanceofcellpolaritymicrotubulecytoskeletonorganizationretrogradeaxonaltransportwoundhealing
C-type lectin domain family 4 member F
2.0
82
81
CLC4FCLC4FP70194P70194endocytosisNKTcellactivation
Selenocysteine lyase
6.8
70
49
SCLYSCLYQ68FT9Q68FT9lipidmetabolicprocessnegativeregulationofcellularresponsetooxidativestressresponsetoinsulinseleniumcompoundmetabolicprocessselenocysteinecatabolicprocess
Selenoprotein M
2.0
39
86
SELMSELMQ8VHC3Q8VHC3adiposetissuedevelopmentcorticosteronesecretionhormonemetabolicprocessmulticellularorganismgrowthresponsetoseleniumion
Natriuretic peptides A
2.0
nan
89
ANFANFP01161P01161cardiacmusclehypertrophyinresponsetostresscellgrowthinvolvedincardiacmusclecelldevelopmentcellularresponsetomechanicalstimuluscGMPbiosyntheticprocesscGMP-mediatedsignalingfemalepregnancyheartdevelopmentmulticellularorganismalwaterhomeostasisnegativeregulationofbloodpressurenegativeregulationofcellgrowthnegativeregulationofcollectinglymphaticvesselconstrictionnegativeregulationofJUNkinaseactivitynegativeregulationofsystemicarterialbloodpressureneuropeptidesignalingpathwaypositiveregulationofcardiacmusclecontractionpositiveregulationofcGMP-mediatedsignalingpositiveregulationofdelayedrectifierpotassiumchannelactivitypositiveregulationofheartratepositiveregulationofhistaminesecretionbymastcellpositiveregulationofpotassiumionexportacrossplasmamembraneproteinfoldingreceptorguanylylcyclasesignalingpathwayregulationofatrialcardiacmusclecellmembranerepolarizationregulationofbloodpressureregulationofbodyfluidlevelsregulationofcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelregulationofhighvoltage-gatedcalciumchannelactivityresponsetohypoxiaresponsetoinsulinsodiumionexportacrossplasmamembranesynapticsignalingvianeuropeptidevasodilation
Beta-klotho
2.1
56
85
KLOTBKLOTBQ86Z14Q86Z14carbohydratemetabolicprocessfibroblastgrowthfactorreceptorsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofMAPKKKcascadebyfibroblastgrowthfactorreceptorsignalingpathway
Lambda-crystallin homolog
7.8
65
49
CRYL1CRYL1Q9Y2S2Q9Y2S2fattyacidmetabolicprocessglucuronatecatabolicprocesstoxylulose5-phosphate
Guanylate-binding protein 5
8.8
54
48
GBP5GBP5Q96PP8Q96PP8cellularresponsetotypeIIinterferoninflammatoryresponsepositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-18productionpositiveregulationofNLRP3inflammasomecomplexassemblyproteinhomotetramerizationproteinlocalizationtoGolgiapparatusresponsetobacterium
Ribonuclease kappa
7.5
nan
58
RNKRNKQ6P5S7Q6P5S7endosomallumenacidificationGolgilumenacidificationintracellularpHreductionlysosomallumenacidificationprotontransmembranetransportreceptor-mediatedendocytosisreceptor-mediatedendocytosisofvirusbyhostcellvacuolaracidification
Beta-mannosidase
2.0
53
85
MANBAMANBAQ8K2I4Q8K2I4glycoproteincatabolicprocessoligosaccharidecatabolicprocess
Claudin-19
2.0
55
84
CLD19CLD19Q9ET38Q9ET38actincytoskeletonreorganizationapicaljunctionassemblybicellulartightjunctionassemblycalcium-independentcell-celladhesionviaplasmamembranecell-adhesionmoleculescelladhesionnegativeregulationofcellmigrationnegativeregulationofcellpopulationproliferationnegativeregulationofgeneexpressionnegativeregulationofwoundhealingneuronalactionpotentialpropagationpositiveregulationofcelljunctionassemblypositiveregulationofgeneexpressionpositiveregulationofproteinphosphorylationregulationoftransepithelialtransporttightjunctionorganization
Leucine-rich repeats and immunoglobulin-like domains protein 3
3.9
77
68
LRIG3LRIG3Q6P1C6Q6P1C6otolithmorphogenesis
Period circadian protein homolog 3
8.6
81
37
PER3PER3O70361O70361circadianregulationofgeneexpressioncircadianrhythmentrainmentofcircadianclockbyphotoperiodnegativeregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationregulationofcircadiansleep/wakecyclesleep
Pleckstrin homology domain-containing family B member 1
9.1
73
43
PKHB1PKHB1Q9QYE9Q9QYE9regulationofcelldifferentiation
Galactocerebrosidase
2.0
89
79
✔
GALCGALCP54818P54818galactosylceramidecatabolicprocessmyelination
Zinc finger protein 57
3.9
39
88
ZFP57ZFP57Q8C6P8Q8C6P8DNAmethylationinvolvedinembryodevelopmentgenomicimprintingmaintenanceofDNAmethylationnegativeregulationoftranscriptionbyRNApolymeraseIIregulationofgeneexpressionbygenomicimprintingregulationofgeneticimprintingregulationoftranscriptionbyRNApolymeraseII
CD40 ligand
4.2
37
77
CD40LCD40LP29965P29965BcelldifferentiationBcellproliferationCD40signalingpathwayinflammatoryresponseintegrin-mediatedsignalingpathwayisotypeswitchingleukocytecell-celladhesionnegativeregulationofapoptoticprocessplateletactivationpositiveregulationofendothelialcellapoptoticprocesspositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-4productionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofTcellproliferationregulationofimmunoglobulinproductionTcellcostimulation
FXYD domain-containing ion transport regulator 4
8.7
29
53
FXYD4FXYD4Q63113Q63113inorganiccationtransmembranetransportregulationofiontransport
Immunoglobulin kappa variable 1-39
2.0
83
82
KV139KV139P01600P01600adaptiveimmuneresponseimmuneresponse
Histidine-rich glycoprotein
2.1
69
88
HRGHRGQ28640Q28640defenseresponsetofungusfibrinolysisnegativeregulationofangiogenesisnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofcelladhesionnegativeregulationofcelladhesionmediatedbyintegrinnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofendothelialcellchemotaxisnegativeregulationoflamellipodiumassemblynegativeregulationofvascularendothelialgrowthfactorsignalingpathwayplateletactivationpositiveregulationofapoptoticprocesspositiveregulationofbloodvesselremodelingpositiveregulationoffocaladhesionassemblypositiveregulationofimmuneresponsetotumorcellregulationofactincytoskeletonorganizationregulationofbloodcoagulationregulationofgeneexpressionregulationofpeptidyl-tyrosinephosphorylationregulationofplasminogenactivationregulationofplateletactivationregulationofprotein-containingcomplexassembly
B-cell differentiation antigen CD72
2.0
58
87
CD72CD72P21855P21855
Igh protein
2.0
82
80
I6L985I6L985I6L985I6L985
Somatostatin
2.0
nan
92
SMSSMSP61278P61278cellsurfacereceptorsignalingpathwaycell-cellsignalingchemicalsynaptictransmissiondigestionGprotein-coupledreceptorsignalingpathwayhormone-mediatedapoptoticsignalingpathwayhyperosmoticresponsenegativeregulationofcellpopulationproliferationregulationofcellmigrationregulationofpostsynapticmembraneneurotransmitterreceptorlevelsresponsetoacidicpHresponsetoaminoacidresponsetoheatresponsetonutrientresponsetosteroidhormoneresponsetoxenobioticstimulus
CDw150
2.0
60
85
Q9GJT3Q9GJT3Q9GJT3Q9GJT3lymphocyteactivation
Tumor necrosis factor ligand superfamily member 18
2.1
70
82
TNF18TNF18Q80YG2Q80YG2adaptiveimmuneresponsenegativeregulationofT-helper17celllineagecommitmentpositiveregulationofcelladhesionpositiveregulationofinflammatoryresponsepositiveregulationofleukocytemigrationpositiveregulationofmacrophagechemotaxispositiveregulationofmonocytechemotaxispositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationoftyrosinephosphorylationofSTATproteinregulationofdendriticcellchemotaxisregulationofprotein-containingcomplexassemblyregulationofTcellproliferationTcellproliferationinvolvedinimmuneresponsetumornecrosisfactor-mediatedsignalingpathway
Chloride intracellular channel protein 1
2.0
53
85
✔
CLIC1CLIC1O00299O00299chloridetransportplateletaggregationpositiveregulationofosteoblastdifferentiationregulationofiontransmembranetransportregulationofmitochondrialmembranepotentialsignaltransduction
39S ribosomal protein L10, mitochondrial
4.6
56
82
RM10RT18AQ7Z7H8Q9NVS2mitochondrialtranslationtranslation
Glutamyl aminopeptidase
2.8
62
87
AMPEAMPEQ07075Q07075angiogenesisangiotensinmaturationcellmigrationcellpopulationproliferationcell-cellsignalingglomerulusdevelopmentpeptidecatabolicprocessproteolysisregulationofbloodpressureregulationofsystemicarterialbloodpressurebyrenin-angiotensinsignaltransduction
S-phase kinase-associated protein 1
4.3
nan
79
✔
SKP1FXL17P63208Q9UF56chromatinremodelingmaintenanceofproteinlocationinnucleuspositiveregulationofubiquitinproteinligaseactivityproteinK48-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationproteinubiquitinationSCF-dependentproteasomalubiquitin-dependentproteincatabolicprocessentrainmentofcircadianclockbyphotoperiodG2/Mtransitionofmitoticcellcyclenervoussystemdevelopmentneuralcrestcelldifferentiationproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinqualitycontrolformisfoldedorincompletelysynthesizedproteinsregulationofcellcycleregulationofsmoothenedsignalingpathway
Actin-related protein 2
5.7
74
57
✔
ARP2ARP2A7MB62A7MB62Arp2/3complex-mediatedactinnucleationpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationoflamellipodiumassemblypositiveregulationoftranscriptionbyRNApolymeraseII
Methyl-CpG-binding domain protein 4
6.2
28
67
✔
MBD4MBD4O95243O95243depyrimidinationDNArepair
Calmodulin-regulated spectrin-associated protein 3
4.6
55
68
CAMP3CAMP3Q80VC9Q80VC9ciliummovementcytoplasmicmicrotubuleorganizationembryodevelopmentendinginbirthoregghatchingepithelialcell-celladhesionestablishmentofepithelialcellapical/basalpolarityestablishmentormaintenanceofmicrotubulecytoskeletonpolarityinuteroembryonicdevelopmentmicrotubuleanchoringmicrotubulecytoskeletonorganizationnegativeregulationofmicrotubuledepolymerizationneuronprojectiondevelopmentproteintransportalongmicrotubuleregulationofcellmigrationregulationoffocaladhesionassemblyregulationofGolgiorganizationregulationofmicrotubulecytoskeletonorganizationregulationofmicrotubulepolymerizationregulationoforganelleorganizationzonulaadherensmaintenance
Dr1-associated corepressor
8.6
51
46
✔
NC2ANC2BQ14919Q01658negativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptiontranscriptionbyRNApolymeraseIIchromatinremodelinghistoneH3acetylationhistoneH3-K14acetylationregulationofcellcycleregulationofcelldivisionregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylationRNApolymeraseIIpreinitiationcomplexassembly
FAS-associated death domain protein
9.5
49
44
✔
FADDFADDQ13158Q13158activationofcysteine-typeendopeptidaseactivityapoptoticprocessapoptoticsignalingpathwaybehavioralresponsetococainecellularresponsetomechanicalstimulusdeath-inducingsignalingcomplexassemblydefenseresponsetovirusextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsinnateimmuneresponsekidneydevelopmentlymphnodedevelopmentmotorneuronapoptoticprocessnecroptoticsignalingpathwaynegativeregulationofactivation-inducedcelldeathofTcellsnegativeregulationofnecroptoticprocesspositiveregulationofactivatedTcellproliferationpositiveregulationofadaptiveimmuneresponsepositiveregulationofapoptoticprocesspositiveregulationofCD8-positivealpha-betacytotoxicTcellextravasationpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-8productionpositiveregulationofmacrophagedifferentiationpositiveregulationofproteolysispositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIinterferon-mediatedsignalingpathwaypositiveregulationoftypeIIinterferonproductionresponsetomorphinespleendevelopmentTcelldifferentiationinthymusTcellhomeostasisthymusdevelopmentTRAIL-activatedapoptoticsignalingpathway
Zinc finger Y-chromosomal protein
3.8
35
87
ZFYZFYP08048P08048positiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Proton-coupled zinc antiporter SLC30A8
4.2
nan
85
ZNT8ZNT8Q8IWU4Q8IWU4cellularzincionhomeostasisinsulinprocessinginsulinsecretionpositiveregulationofinsulinsecretionregulationofsequesteringofzincionregulationofvesicle-mediatedtransportresponsetoglucoseresponsetointerleukin-1responsetotypeIIinterferonresponsetozincionsequesteringofzincionzincionimportintoorganellezinciontransmembranetransportzinciontransport
Protein C-ets-1
9.0
41
48
ETS1ETS1P27577P27577celldifferentiationcellmotilityimmunesystemprocessnegativeregulationofcellcyclenegativeregulationofinflammatoryresponsePMLbodyorganizationpositiveregulationofangiogenesispositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofendothelialcellmigrationpositiveregulationoferythrocytedifferentiationpositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofmiRNAtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofangiogenesisregulationofapoptoticprocessregulationofextracellularmatrixdisassemblyregulationoftranscriptionbyRNApolymeraseIIresponsetoantibiotictranscriptionbyRNApolymeraseII
Breast cancer metastasis-suppressor 1
2.1
56
85
BRMS1BRMS1Q9HCU9Q9HCU9apoptoticprocesshistonedeacetylationnegativeregulationofcellmigrationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofstemcellpopulationmaintenancenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofanoikispositiveregulationofproteindeacetylationpositiveregulationofstemcellpopulationmaintenanceregulationofapoptoticprocess
Cation channel sperm-associated auxiliary subunit epsilon
2.0
55
89
CTSRECTSREP0DP43P0DP43flagellatedspermmotilityspermcapacitation
Protein capicua homolog
2.0
33
89
CICCICQ96RK0Q96RK0braindevelopmentlearningmemorynegativeregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIsocialbehavior
Serine/threonine-protein kinase MARK2
2.1
50
81
MARK2MARK2O08679O08679axondevelopmentestablishmentofcellpolarityestablishmentormaintenanceofcellpolarityregulatingcellshapeestablishmentormaintenanceofepithelialcellapical/basalpolarityintracellularsignaltransductionmicrotubulecytoskeletonorganizationneuronmigrationpeptidyl-serinephosphorylationpositiveregulationofneuronprojectiondevelopmentproteinautophosphorylationproteinphosphorylationregulationofaxonogenesisregulationofcytoskeletonorganizationregulationofmicrotubulebindingregulationofmicrotubulecytoskeletonorganizationregulationofpostsynapseorganizationWntsignalingpathway
Protein FEV
3.0
53
84
FEVFEVQ99581Q99581celldifferentiationneuronfatespecificationneuronmaturationpositiveregulationofgeneexpressionregulationoftranscriptionbyRNApolymeraseII
Activated CDC42 kinase 1
7.0
67
48
ACK1ACK1Q07912Q07912celldifferentiationcellsurfacereceptorsignalingpathwayendocytosisinnateimmuneresponsephosphorylationpositiveregulationofpeptidyl-tyrosinephosphorylationregulationofclathrin-dependentendocytosissmallGTPasemediatedsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
C-type lectin domain family 7 member A
2.0
66
83
CLC7ACLC7AQ6QLQ4Q6QLQ4antifungalinnateimmuneresponsecellactivationcellsurfacepatternrecognitionreceptorsignalingpathwaycell-celladhesioncellularresponsetomoleculeoffungalorigindetectionoffungusdetectionofmoleculeoffungalorigindetectionofyeastinflammatoryresponseinnateimmuneresponseleukocyteactivationinvolvedinimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductioninvolvedinimmuneresponsepositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofdendriticcellcytokineproductionpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-10productionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-23productionpositiveregulationofinterleukin-6productionpositiveregulationofkillingofcellsofanotherorganismpositiveregulationoflymphocyteactivationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofphagocytosispositiveregulationofstress-activatedMAPKcascadepositiveregulationofT-helper17typeimmuneresponsepositiveregulationoftumornecrosisfactorproductionpositiveregulationofwoundhealingregulationofcalcineurin-NFATsignalingcascaderegulationofI-kappaBkinase/NF-kappaBsignalingresponsetomoleculeoffungaloriginresponsetoyeaststimulatoryC-typelectinreceptorsignalingpathway
E3 ubiquitin-protein ligase PPP1R11
4.0
40
78
PP1APP1RBP62136O60927beta-catenindestructioncomplexdisassemblybranchingmorphogenesisofanepithelialtubecellcyclecelldivisioncircadianregulationofgeneexpressiondephosphorylationentrainmentofcircadianclockbyphotoperiodglycogenmetabolicprocesslungdevelopmentnegativeregulationofproteinbindingpeptidyl-serinedephosphorylationpeptidyl-threoninedephosphorylationpositiveregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandproteindephosphorylationregulationofcanonicalWntsignalingpathwayregulationofcircadianrhythmregulationofglycogenbiosyntheticprocessregulationofglycogencatabolicprocessregulationoftranslationalinitiationbyeIF2alphadephosphorylationresponsetoleadiondefenseresponsetoGram-positivebacteriumnegativeregulationofcytokineproductionnegativeregulationofphosphoproteinphosphataseactivityubiquitin-dependentproteincatabolicprocess
Hemagglutinin glycoprotein
9.5
nan
51
E2RZS2Q9GJT3E2RZS2Q9GJT3viralentryintohostcellvirionattachmenttohostcelllymphocyteactivation
T-cell receptor alpha chain V region CTL-F3
2.0
82
81
TVA3TVA3P06323P06323adaptiveimmuneresponse
Insulin gene enhancer protein ISL-1
3.9
48
91
ISL1ISL1P61372P61372atrialseptummorphogenesisaxonregenerationaxonogenesiscanonicalWntsignalingpathwaycardiaccellfatedeterminationcardiacmusclecellmyoblastdifferentiationcardiacrightventriclemorphogenesiscellpopulationproliferationcellularresponsetoglucocorticoidstimulusendocardialcushionmorphogenesisheartdevelopmentheartmorphogenesisinnervationmesenchymalcelldifferentiationnegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationnegativeregulationofinflammatoryresponsenegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationofneuronapoptoticprocessnegativeregulationofneurondifferentiationnegativeregulationofprotein-containingcomplexassemblynegativeregulationoftranscriptionbyRNApolymeraseIIneuralcrestcellmigrationneurondifferentiationneuronfatecommitmentneuronfatespecificationoutflowtractmorphogenesisoutflowtractseptummorphogenesispancreasdevelopmentperipheralnervoussystemneuronaxonogenesisperipheralnervoussystemneurondevelopmentpharyngealsystemdevelopmentpituitaryglanddevelopmentpositiveregulationofangiogenesispositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNAbindingpositiveregulationofepithelialtomesenchymaltransitionpositiveregulationofgranulocytecolony-stimulatingfactorproductionpositiveregulationofgranulocytemacrophagecolony-stimulatingfactorproductionpositiveregulationofhistoneacetylationpositiveregulationofinsulinsecretionpositiveregulationofinterleukin-1alphaproductionpositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagecolony-stimulatingfactorproductionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftumornecrosisfactorproductionpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularendothelialgrowthfactorproductionregulationofDNA-templatedtranscriptionregulationofgeneexpressionregulationofheartratebycardiacconductionregulationofsecondaryheartfieldcardioblastproliferationregulationoftranscriptionbyRNApolymeraseIIretinalganglioncellaxonguidancesecondaryheartfieldspecificationsensorysystemdevelopmentsinoatrialnodecelldevelopmentspinalcordmotorneuroncellfatespecificationspinalcordmotorneurondifferentiationstemcelldifferentiationtranscriptionbyRNApolymeraseIItrigeminalnervedevelopmentventricularcardiacmuscletissuemorphogenesisvisceralmotorneurondifferentiation
Homeobox protein NANOG
2.0
52
85
NANOGNANOGQ80Z64Q80Z64BMPsignalingpathwaycelldedifferentiationcellularresponsetoerythropoietincellularresponsetorapamycinembryonicpatternspecificationendodermalcellfatespecificationgeneexpressiongonaddevelopmentmesodermalcellfatecommitmentmultidimensionalcellgrowthnegativeregulationofBMPsignalingpathwaynegativeregulationofcellfatecommitmentnegativeregulationofendodermalcellfatespecificationnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofmitoticcellcyclepositiveregulationoftranscriptionbyRNApolymeraseIIregulationofstemcelldivisionregulationoftranscriptionbyRNApolymeraseIIresponsetoorganicsubstanceresponsetoretinoicacidsomaticstemcellpopulationmaintenancestemcelldifferentiationstemcelldivisionstemcellpopulationmaintenancetissueregeneration
Striatin-interacting protein 1
4.1
69
82
STRP1STRP1Q5VSL9Q5VSL9corticalactincytoskeletonorganizationcytoskeletonorganizationregulationofcellmorphogenesis
Serine/threonine-protein kinase DCLK1
4.6
58
67
DCLK1DCLK1O15075O15075axonextensioncentralnervoussystemdevelopmentcentralnervoussystemprojectionneuronaxonogenesisdendritemorphogenesisendosomaltransportforebraindevelopmentintracellularsignaltransductionnegativeregulationofproteinlocalizationtonucleusnervoussystemdevelopmentneuronmigrationneuronprojectionmorphogenesispeptidyl-serinephosphorylationproteinlocalizationtonucleusproteinphosphorylationresponsetovirus
Prostacyclin receptor
9.3
nan
48
PI2RPI2RP43252P43252adenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayinflammatoryresponsenegativeregulationofplatelet-derivedgrowthfactorreceptorsignalingpathwaynegativeregulationofsmoothmusclecellproliferationpositiveregulationofcytosoliccalciumionconcentrationresponsetolipopolysaccharide
Lipopolysaccharide-binding protein
2.1
69
83
LBPLBPQ61805Q61805acute-phaseresponsecellsurfacepatternrecognitionreceptorsignalingpathwaycellularresponsetolipopolysaccharidecellularresponsetolipoteichoicaciddefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdetectionofmoleculeofbacterialorigininnateimmuneresponseleukocytechemotaxisinvolvedininflammatoryresponselipopolysaccharidetransportlipopolysaccharide-mediatedsignalingpathwaymacromoleculelocalizationmacrophageactivationinvolvedinimmuneresponsenegativeregulationoftumornecrosisfactorproductionneutrophilchemotaxisopsonizationpositiveregulationofchemokineproductionpositiveregulationofcytolysispositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofmacrophageactivationpositiveregulationofneutrophilchemotaxispositiveregulationofphagocytosisengulfmentpositiveregulationofrespiratoryburstinvolvedininflammatoryresponsepositiveregulationoftoll-likereceptor4signalingpathwaypositiveregulationoftumornecrosisfactorproductionregulationofmembranepermeabilityresponsetolipopolysaccharide
Tumor necrosis factor
2.0
62
84
TNFATNFAP06804P06804activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessacuteinflammatoryresponseanimalorganmorphogenesisapoptoticprocessapoptoticsignalingpathwaycalcium-mediatedsignalingcellactivationcellularextravasationcellularresponsetoaminoacidstimuluscellularresponsetoamyloid-betacellularresponsetolipopolysaccharidecellularresponsetonicotinecellularresponsetoorganiccycliccompoundcellularresponsetoretinoicacidcellularresponsetotoxicsubstancecellularresponsetotypeIIinterferonchronicinflammatoryresponsetoantigenicstimuluscircadianrhythmcorticalactincytoskeletonorganizationdefenseresponsedefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumdetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainembryonicdigestivetractdevelopmentendothelialcellapoptoticprocessepithelialcellproliferationinvolvedinsalivaryglandmorphogenesisextracellularmatrixorganizationextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsglucosemetabolicprocesshumoralimmuneresponseI-kappaBkinase/NF-kappaBsignalinginflammatoryresponseintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageJNKcascadeleukocytemigrationleukocytemigrationinvolvedininflammatoryresponseleukocytetetheringorrollinglipopolysaccharide-mediatedsignalingpathwayliverregenerationmacrophageactivationinvolvedinimmuneresponseMAPKcascademicroglialcellactivationnecroptoticsignalingpathwaynegativeregulationofalkalinephosphataseactivitynegativeregulationofamyloid-betaclearancenegativeregulationofapoptoticprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofbicellulartightjunctionassemblynegativeregulationofbileacidsecretionnegativeregulationofbloodvesselendothelialcellmigrationnegativeregulationofbranchinginvolvedinlungmorphogenesisnegativeregulationofcellpopulationproliferationnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofcytokineproductioninvolvedinimmuneresponsenegativeregulationofDNA-templatedtranscriptionnegativeregulationofendothelialcellproliferationnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofglucoseimportnegativeregulationofheartratenegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationofinterleukin-6productionnegativeregulationofL-glutamateimportacrossplasmamembranenegativeregulationoflipidcatabolicprocessnegativeregulationofmitoticcellcyclenegativeregulationofmyelinationnegativeregulationofmyoblastdifferentiationnegativeregulationofmyosin-light-chain-phosphataseactivitynegativeregulationofosteoblastdifferentiationnegativeregulationofoxidativephosphorylationnegativeregulationofprotein-containingcomplexdisassemblynegativeregulationofsignalingreceptoractivitynegativeregulationofsystemicarterialbloodpressurenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofvascularwoundhealingnegativeregulationofviralgenomereplicationosteoclastdifferentiationpositiveregulationofactionpotentialpositiveregulationofamyloid-betaformationpositiveregulationofapoptoticprocesspositiveregulationofbloodmicroparticleformationpositiveregulationofcalcidiol1-monooxygenaseactivitypositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcelladhesionpositiveregulationofcellpopulationproliferationpositiveregulationofchemokine(C-X-Cmotif)ligand2productionpositiveregulationofchemokineproductionpositiveregulationofchronicinflammatoryresponsetoantigenicstimuluspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinexecutionphaseofapoptosispositiveregulationofcytokineproductionpositiveregulationofcytokineproductioninvolvedininflammatoryresponsepositiveregulationofDNAbiosyntheticprocesspositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofextrinsicapoptoticsignalingpathwaypositiveregulationoffevergenerationpositiveregulationoffractalkineproductionpositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofhairfollicledevelopmentpositiveregulationofhepatocyteproliferationpositiveregulationofheterotypiccell-celladhesionpositiveregulationofhumoralimmuneresponsemediatedbycirculatingimmunoglobulinpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofI-kappaBphosphorylationpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-18productionpositiveregulationofinterleukin-33productionpositiveregulationofinterleukin-6productionpositiveregulationofinterleukin-8productionpositiveregulationofJNKcascadepositiveregulationofJUNkinaseactivitypositiveregulationofleukocyteadhesiontoarterialendothelialcellpositiveregulationofleukocyteadhesiontovascularendothelialcellpositiveregulationofMAPkinaseactivitypositiveregulationofMAPKcascadepositiveregulationofmembraneproteinectodomainproteolysispositiveregulationofmiRNAtranscriptionpositiveregulationofmitoticnucleardivisionpositiveregulationofneuronapoptoticprocesspositiveregulationofneutrophilactivationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofnitric-oxidesynthaseactivitypositiveregulationofnitrogencompoundmetabolicprocesspositiveregulationofosteoclastdifferentiationpositiveregulationofoxidativestress-inducedneurondeathpositiveregulationofpeptidyl-serinephosphorylationpositiveregulationofphagocytosispositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofpodosomeassemblypositiveregulationofprogrammedcelldeathpositiveregulationofproteincatabolicprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtocellsurfacepositiveregulationofproteinlocalizationtoplasmamembranepositiveregulationofproteinphosphorylationpositiveregulationofproteintransportpositiveregulationofprotein-containingcomplexassemblypositiveregulationofprotein-containingcomplexdisassemblypositiveregulationofreceptorsignalingpathwayviaJAK-STATpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsuperoxidedismutaseactivitypositiveregulationofsynaptictransmissionpositiveregulationofsynoviocyteproliferationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranslationalinitiationbyironpositiveregulationoftypeIIinterferonproductionpositiveregulationoftyrosinephosphorylationofSTATproteinpositiveregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofvitaminDbiosyntheticprocessproteinkinaseBsignalingproteinlocalizationtoplasmamembraneregulationofbranchinginvolvedinsalivaryglandmorphogenesisregulationofcellpopulationproliferationregulationofendothelialcellapoptoticprocessregulationofestablishmentofendothelialbarrierregulationofI-kappaBkinase/NF-kappaBsignalingregulationofimmunoglobulinproductionregulationofinflammatoryresponseregulationofinsulinsecretionregulationofosteoclastdifferentiationregulationofproteinphosphorylationregulationofproteinsecretionregulationofreactiveoxygenspeciesmetabolicprocessregulationofsynapseorganizationregulationoftranscriptionbyRNApolymeraseII"responseto335-triiodo-L-thyronine"responsetoactivityresponsetoethanolresponsetofructoseresponsetoglucocorticoidresponsetogoldnanoparticleresponsetoGram-negativebacteriumresponsetohypoxiaresponsetoisolationstressresponsetolipopolysaccharideresponsetomacrophagecolony-stimulatingfactorresponsetonutrientlevelsresponsetoorganicsubstanceresponsetoparacetamolresponsetoradiationresponsetovirusresponsetoxenobioticstimulussequesteringoftriglyceridesignaltransductionskeletalmusclecontractiontoll-likereceptor3signalingpathwaytumornecrosisfactor-mediatedsignalingpathwayvascularendothelialgrowthfactorproductionvasodilation
Insulin gene enhancer protein ISL-2
3.9
44
85
ISL2ISL2Q9CXV0Q9CXV0axonogenesisnegativeregulationofneurondifferentiationneurondifferentiationneuronfatecommitmentneuronfatespecificationregulationoftranscriptionbyRNApolymeraseIIretinalganglioncellaxonguidancespinalcordmotorneuroncellfatespecificationvisceralmotorneurondifferentiation
Uteroglobin
2.0
nan
94
UTERUTERP11684P11684embryoimplantationfemalepregnancynegativeregulationofinterleukin-13productionnegativeregulationofinterleukin-4productionnegativeregulationofinterleukin-5productionnegativeregulationofTcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftypeIIinterferonproductionregulationofinflammatoryresponseregulationofmRNAstabilityresponsetocytokineresponsetofibroblastgrowthfactorresponsetoglucocorticoidresponsetolipopolysaccharideresponsetoozoneresponsetosilicondioxideresponsetoxenobioticstimulussignaltransductionTcellproliferation
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
4.0
75
71
ACY3ACY3Q91XE4Q91XE4
NF-kappa-B inhibitor beta
8.9
70
39
IKBBIKBBQ60778Q60778cellularresponsetolipopolysaccharidecytoplasmicsequesteringofNF-kappaBinflammatoryresponseregulationofI-kappaBkinase/NF-kappaBsignalingsignaltransduction
Bcl-2-like protein 10
7.0
64
54
B2L10B2L10Q9Z0F3Q9Z0F3apoptoticprocessextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagemicrotubuleorganizingcenterorganizationnegativeregulationofapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayinabsenceofligandnegativeregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofapoptoticprocess
TNF superfamily member 18
2.0
63
85
G1TIM1G1TIM1G1TIM1G1TIM1positiveregulationofcelladhesionpositiveregulationofleukocytemigrationpositiveregulationoftyrosinephosphorylationofSTATproteinTcellproliferationinvolvedinimmuneresponsetumornecrosisfactor-mediatedsignalingpathway
Thyrotropin receptor
2.0
57
87
TSHRTSHRP16473P16473activationofadenylatecyclaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwaycellsurfacereceptorsignalingpathwaycell-cellsignalingcellularresponsetoglycoproteincellularresponsetothyrotropin-releasinghormoneGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerhormone-mediatedsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcold-inducedthermogenesisthyroid-stimulatinghormonesignalingpathway
C-type natriuretic peptide
2.0
nan
88
ANFCANFCP23582P23582angiogenesisbloodvesseldiametermaintenancebloodvesselremodelingc-di-GMPsignalingcellularcalciumionhomeostasiscellularresponsetoglycoproteincGMPbiosyntheticprocesscGMP-mediatedsignalingchromosomeorganizationcumuluscelldifferentiationgastricemptyinggrowthplatecartilagechondrocytedifferentiationgrowthplatecartilagechondrocyteproliferationmeioticcellcycleprocessinvolvedinoocytematurationmulticellularorganismallocomotionnegativeregulationofcellpopulationproliferationnegativeregulationofcollagenbiosyntheticprocessnegativeregulationofDNAbiosyntheticprocessnegativeregulationofmeioticcellcyclenegativeregulationofneuronapoptoticprocessnegativeregulationofoocytematurationossificationpositiveregulationofcGMP-mediatedsignalingpositiveregulationofosteoblastdifferentiationpost-embryonicdevelopmentproteinfoldingreceptorguanylylcyclasesignalingpathwayregulationofmulticellularorganismgrowthregulationofsmoothmusclecellproliferationresponsetoaxoninjuryresponsetoethanolresponsetohypoxiaresponsetoischemiaresponsetooxygen-glucosedeprivationresponsetoxenobioticstimulus
Translocon-associated protein subunit delta
2.0
46
89
SSRDSSRDP51571P51571
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
2.9
68
80
MAGI1MAGI1Q6RHR9Q6RHR9positiveregulationofcell-celladhesionsignaltransduction
Methylated-DNA--protein-cysteine methyltransferase
3.9
42
82
E5BBQ0E5BBQ0E5BBQ0E5BBQ0DNAmodificationDNArepairmethylation
Calcium homeostasis modulator protein 6
4.1
nan
84
CAHM6CAHM6Q5R3K3Q5R3K3
DNA repair protein RAD52 homolog
9.4
nan
51
RAD52RAD52P43351P43351cellularresponsetooxidativestressDNAdouble-strandbreakprocessinginvolvedinrepairviasingle-strandannealingDNArecombinaseassemblyDNArecombinationdouble-strandbreakrepairdouble-strandbreakrepairviahomologousrecombinationdouble-strandbreakrepairviasingle-strandannealingmitoticrecombinationregulationofnucleotide-excisionrepair
Zona pellucida sperm-binding protein 3
2.0
58
88
ZP3ZP3P10761P10761bindingofspermtozonapellucidablastocystformationeggcoatformationhumoralimmuneresponsemediatedbycirculatingimmunoglobulinnegativeregulationofbindingofspermtozonapellucidanegativeregulationofDNA-templatedtranscriptionoocytedevelopmentpositiveregulationofacrosomalvesicleexocytosispositiveregulationofacrosomereactionpositiveregulationofantralovarianfolliclegrowthpositiveregulationofDNA-templatedtranscriptionpositiveregulationofhumoralimmuneresponsepositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-4productionpositiveregulationofleukocytemigrationpositiveregulationofovarianfollicledevelopmentpositiveregulationofTcellproliferationpositiveregulationoftypeIIinterferonproductionpositiveregulationoftypeIVhypersensitivityregulationofsignalingreceptoractivity
Striatin-3
7.2
40
57
STRN3STRN3Q13033Q13033negativeregulationofDNA-templatedtranscriptionnegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionbyRNApolymeraseIIresponsetoestradiol
Variable region-beta 8.5
1.9
89
82
A2NAI0A2NAI0A2NAI0A2NAI0
NACHT, LRR and PYD domains-containing protein 12
2.0
75
79
NAL12NAL12P59046P59046activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesscellularresponsetocytokinestimulusdendriticcellmigrationERK1andERK2cascadenegativeregulationofcytokineproductionnegativeregulationofERK1andERK2cascadenegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofinflammatoryresponsenegativeregulationofinterleukin-1productionnegativeregulationofinterleukin-6productionnegativeregulationofNF-kappaBtranscriptionfactoractivitynegativeregulationofNIK/NF-kappaBsignalingnegativeregulationofproteinautophosphorylationnegativeregulationofsignaltransductionnegativeregulationofTollsignalingpathwayNIK/NF-kappaBsignalingpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofMHCclassIbiosyntheticprocesspositiveregulationofNIK/NF-kappaBsignalingregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessregulationofI-kappaBkinase/NF-kappaBsignalingregulationofinflammatoryresponseregulationofinterleukin-18productionsignaltransduction
Spindle assembly abnormal protein 6 homolog
3.3
31
85
SAS6SAS6Q6UVJ0Q6UVJ0centriolereplicationcentrosomeduplicationpositiveregulationofcentriolereplicationpositiveregulationofG1/Stransitionofmitoticcellcyclepositiveregulationofspindleassemblyregulationofmitoticspindleorganization
Lymphocyte antigen 6 complex locus protein G6d
3.7
73
76
LY66DLY66DO95868O95868acetylcholinereceptorsignalingpathway
Dynamin-binding protein
5.3
55
64
DNMBPDNMBPQ6XZF7Q6XZF7agingintracellularsignaltransductionregulationofcellshaperegulationofsmallGTPasemediatedsignaltransduction
Ubiquitin carboxyl-terminal hydrolase 11
2.0
46
83
UBP11UBP11Q5D006Q5D006proteindeubiquitinationubiquitin-dependentproteincatabolicprocess
Lamina-associated polypeptide 2, isoforms alpha/zeta
9.4
50
40
✔
LAP2ALAP2AQ61033Q61033regulationofDNA-templatedtranscription
Anthrax toxin receptor 2
2.1
nan
92
ANTR2ANTR2P58335P58335toxintransport
Cytochrome c oxidase subunit 6A2, mitochondrial
4.2
47
74
CX6A2CX6A2P43023P43023mitochondrialelectrontransportcytochromectooxygen
G protein-activated inward rectifier potassium channel 2
2.0
nan
91
KCNJ6KCNJ6P48542P48542negativeregulationofinsulinsecretionpotassiumionimportacrossplasmamembraneregulationofiontransmembranetransport
Methylated-DNA--protein-cysteine methyltransferase
3.2
nan
82
MGMTMGMTP16455P16455cellularresponsetoionizingradiationcellularresponsetoorganiccycliccompoundcellularresponsetooxidativestressDNAdealkylationinvolvedinDNArepairDNAligationDNArepairmammaryglandepithelialcelldifferentiationnegativeregulationofapoptoticprocesspositiveregulationofdouble-strandbreakrepairregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessresponsetoethanolresponsetofolicacidresponsetotoxicsubstanceresponsetoxenobioticstimulus
Tumor necrosis factor ligand superfamily member 15
3.4
nan
82
TNF15TNF15Q8NFE9Q8NFE9activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofNF-kappaB-inducingkinaseactivityimmuneresponsesignaltransduction
Protein mono-ADP-ribosyltransferase PARP16
9.2
nan
45
PAR16PAR16Q8N5Y8Q8N5Y8cellularresponsetoleukemiainhibitoryfactorendoplasmicreticulumunfoldedproteinresponseIRE1-mediatedunfoldedproteinresponseNADbiosynthesisvianicotinamideribosidesalvagepathwaynegativeregulationofcelldeathpositiveregulationofproteinserine/threoninekinaseactivityproteinauto-ADP-ribosylationviralproteinprocessing
Urotensin-2
2.0
12
91
UTS2UTS2O95399O95399bloodvesseldiametermaintenancechemicalsynaptictransmissionmusclecontractionregulationofbloodpressure
Calcitonin
2.0
nan
90
CALCCALCP01258P01258activationofadenylatecyclaseactivityactivationofproteinkinaseactivityadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayagingarteryvasodilationinvolvedinbaroreceptorresponsetoincreasedsystemicarterialbloodpressurecellularresponsetonervegrowthfactorstimuluscellularresponsetotumornecrosisfactordetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainembryoimplantationfeedingbehaviorinflammatoryresponsemonocytechemotaxisnegativeregulationofboneresorptionnegativeregulationofDNA-templatedtranscriptionnegativeregulationofossificationnegativeregulationofsmoothmusclecontractionneuropeptidesignalingpathwayossificationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofcytosoliccalciumionconcentrationinvolvedinphospholipaseC-activatingGprotein-coupledsignalingpathwayregulationofcytosoliccalciumionconcentrationregulationofheartcontractionresponsetoheatresponsetopainsmoothmusclecontraction
Nuclear cap-binding protein subunit 2
8.5
nan
52
NCBP2NCBP2P52298P52298alternativemRNAsplicingviaspliceosomecap-dependenttranslationalinitiationhistonemRNAmetabolicprocessmiRNA-mediatedgenesilencing"mRNA3-endprocessing"mRNAcissplicingviaspliceosomemRNAexportfromnucleusmRNAsplicingviaspliceosomemRNAtranscriptionbyRNApolymeraseIInuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecay"positiveregulationofmRNA3-endprocessing"positiveregulationofphosphorylationofRNApolymeraseIIC-terminaldomainpositiveregulationofRNAexportfromnucleuspositiveregulationoftranscriptionelongationbyRNApolymeraseIIpre-mRNAcleavagerequiredforpolyadenylationprimarymiRNAprocessingregulationoftranslationalinitiationRNAsplicingsnRNAexportfromnucleus
BolA-like protein 1
10.0
15
48
✔
BOLA1BOLA1Q9D8S9Q9D8S9
Lysosome-associated membrane glycoprotein 2
2.0
nan
88
LAMP2LAMP2P17047P17047autophagosomematurationautophagycellularresponsetostarvationchaperone-mediatedautophagyestablishmentofproteinlocalizationtoorganellelysosomalproteincatabolicprocessmusclecellcellularhomeostasisnegativeregulationofprotein-containingcomplexassemblyproteinstabilizationproteintargetingproteintargetingtolysosomeinvolvedinchaperone-mediatedautophagyregulationofproteinstability
3-oxo-5-alpha-steroid 4-dehydrogenase 2
2.0
nan
88
S5A2S5A2P31213P31213androgenbiosyntheticprocessandrogenmetabolicprocessbiphenylmetabolicprocessbonedevelopmentcelldifferentiationcell-cellsignalingdibenzo-p-dioxinmetabolicprocessfemalegenitaliadevelopmenthippocampusdevelopmenthypothalamusdevelopmentmalegenitaliadevelopmentmalegonaddevelopmentphthalatemetabolicprocessresponsetofollicle-stimulatinghormoneresponsetonutrientlevelsresponsetopeptidehormoneresponsetosteroidhormoneresponsetotestosteroneresponsetoxenobioticstimulussteroidbiosyntheticprocesssteroidcatabolicprocesstestosteronebiosyntheticprocess
Potassium voltage-gated channel subfamily A member 2
3.8
nan
81
KCNA2KCNA2P63142P63142cerebralcortexdevelopmentcorpuscallosumdevelopmentneuronalactionpotentialopticnervedevelopmentopticnervestructuralorganizationpotassiumionexportacrossplasmamembranepotassiumiontransmembranetransportproteinhomooligomerizationregulationofcircadiansleep/wakecyclenon-REMsleepregulationofdopaminesecretionregulationofiontransmembranetransportsensoryperceptionofpain
Peroxisomal succinyl-coenzyme A thioesterase
6.6
nan
62
ACOT4ACOT4Q8N9L9Q8N9L9acyl-CoAmetabolicprocessdicarboxylicacidcatabolicprocessdicarboxylicacidmetabolicprocessfattyacidbiosyntheticprocessfattyacidmetabolicprocesslong-chainfattyacidmetabolicprocesssaturatedmonocarboxylicacidmetabolicprocessshort-chainfattyacidmetabolicprocesssuccinyl-CoAmetabolicprocessunsaturatedmonocarboxylicacidmetabolicprocessverylong-chainfattyacidmetabolicprocess
Integrin alpha-2
2.0
63
85
ITA2ITA2P17301P17301animalorganmorphogenesisbloodcoagulationcelladhesioncelladhesionmediatedbyintegrincellpopulationproliferationcell-celladhesioncell-matrixadhesioncell-substrateadhesioncellularresponsetoestradiolstimuluscellularresponsetomechanicalstimuluscollagen-activatedsignalingpathwaydetectionofmechanicalstimulusinvolvedinsensoryperceptionofpainestablishmentofproteinlocalizationfemalepregnancyfocaladhesionassemblyhepatocytedifferentiationhypotonicresponseintegrin-mediatedsignalingpathwaymammaryglanddevelopmentmesodermalcelldifferentiationpositiveregulationofalkalinephosphataseactivitypositiveregulationofcelladhesionpositiveregulationofcellprojectionorganizationpositiveregulationofcollagenbindingpositiveregulationofcollagenbiosyntheticprocesspositiveregulationofDNAbindingpositiveregulationofepithelialcellmigrationpositiveregulationofinflammatoryresponsepositiveregulationofleukocytemigrationpositiveregulationofphagocytosisengulfmentpositiveregulationofpositivechemotaxispositiveregulationofsmoothmusclecellmigrationpositiveregulationofsmoothmusclecellproliferationpositiveregulationofsmoothmusclecontractionpositiveregulationoftranslationpositiveregulationoftransmissionofnerveimpulseresponsetoamineresponsetohypoxiaresponsetoL-ascorbicacidresponsetomuscleactivityresponsetoparathyroidhormoneresponsetoxenobioticstimulusskinmorphogenesissubstrate-dependentcellmigration
TYRO protein tyrosine kinase-binding protein
2.0
nan
94
TYOBPTYOBPO43914O43914actincytoskeletonorganizationapoptoticcellclearanceapoptoticsignalingpathwaycellulardefenseresponseforebraindevelopmentintracellularsignaltransductionmicroglialcellactivationinvolvedinimmuneresponsemyeloidleukocyteactivationnegativeregulationofBcellproliferationnegativeregulationofinterleukin-10productionnegativeregulationoflong-termsynapticpotentiationnegativeregulationoftransforminggrowthfactorbeta1productionneutrophilactivationinvolvedinimmuneresponseosteoclastdifferentiationpositiveregulationofgeneexpressionpositiveregulationofhippocampalneuronapoptoticprocesspositiveregulationofinterleukin-1betaproductionpositiveregulationofinterleukin-6productionpositiveregulationofmacrophagefusionpositiveregulationofmicroglialcellmediatedcytotoxicitypositiveregulationofnaturalkillercellactivationpositiveregulationofneurondeathpositiveregulationofosteoclastdevelopmentpositiveregulationofproteinlocalizationtocellsurfacepositiveregulationofreceptorlocalizationtosynapsepositiveregulationofsuperoxideaniongenerationpositiveregulationoftumornecrosisfactorproductionproteinstabilizationresponsetoaxoninjurysignaltransductionstimulatoryC-typelectinreceptorsignalingpathwaystimulatorykillercellimmunoglobulin-likereceptorsignalingpathway
Leukocyte elastase inhibitor
2.0
35
89
ILEUILEUP30740P30740negativeregulationofendopeptidaseactivitynegativeregulationofinterleukin-1betaproductiontypeBpancreaticcellproliferation
Anthrax toxin receptor 1
4.3
nan
81
ANTR1ANTR1Q9H6X2Q9H6X2actincytoskeletonreorganizationbloodvesseldevelopmentnegativeregulationofextracellularmatrixassemblypositiveregulationofmetallopeptidaseactivityreproductiveprocesssubstrateadhesion-dependentcellspreadingtoxintransport
Phosphatidylinositol phosphatase PTPRQ
5.6
nan
73
PTPRQPTPRQQ9UMZ3Q9UMZ3peptidyl-tyrosinedephosphorylationinvolvedininactivationofproteinkinaseactivityregulationoffatcelldifferentiation
T-cell receptor beta chain V region C5
2.0
87
81
TVB5TVB5P04213P04213adaptiveimmuneresponsecellsurfacereceptorsignalingpathway
Nucleotide exchange factor SIL1
4.7
96
62
SIL1SIL1Q9H173Q9H173cotranslationalproteintargetingtomembraneintracellularproteintransportproteinfolding
Olfactory receptor 51B2
3.9
84
65
O51B2O51B2Q9Y5P1Q9Y5P1
Cytoplasmic dynein 1 intermediate chain 2
6.8
68
51
DC1I2DC1I2Q13409Q13409microtubule-basedmovementtransportalongmicrotubule
Lymphocyte function-associated antigen 3
2.0
78
nan
LFA3LFA3P19256P19256cell-celladhesioncellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonheterotypiccell-celladhesionpositiveregulationofinterleukin-8production
Interferon-induced, double-stranded RNA-activated protein kinase
8.8
54
47
E2AK2E2AK2Q03963Q03963cellularresponsetoaminoacidstarvationdefenseresponsetovirusendoplasmicreticulumunfoldedproteinresponseinnateimmuneresponsenegativeregulationofapoptoticprocessnegativeregulationofosteoblastproliferationnegativeregulationoftranslationnegativeregulationofviralgenomereplicationpositiveregulationofapoptoticprocesspositiveregulationofchemokineproductionpositiveregulationofcytokineproductionpositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofNIK/NF-kappaBsignalingpositiveregulationofstress-activatedMAPKcascadeproteinautophosphorylationproteinphosphorylationregulationofhematopoieticprogenitorcelldifferentiationregulationofhematopoieticstemcelldifferentiationregulationofhematopoieticstemcellproliferationregulationofNLRP3inflammasomecomplexassemblyresponsetointerferon-alpharesponsetolipopolysaccharideresponsetotoxicsubstanceresponsetovirusresponsetovitaminEtranslation
Lactadherin
2.0
45
85
MFGMMFGMP21956P21956angiogenesisapoptoticcellclearancecelladhesionsinglefertilization
T-cell surface glycoprotein CD8 beta chain
2.0
84
80
CD8BCD8BP10300P10300adaptiveimmuneresponseTcellactivationTcellreceptorsignalingpathway
Ig lambda-1 chain V regions MOPC 104E/RPC20/J558/S104
2.0
93
78
LV1BLV1BP01724P01724adaptiveimmuneresponseimmuneresponse
Ig lambda-1 chain V region
2.0
94
79
LV1ALV1AP01723P01723adaptiveimmuneresponseimmuneresponse
Ig lambda-1 chain V region S43
2.1
85
79
LV1ELV1EP01727P01727adaptiveimmuneresponseimmuneresponse
Smoothelin
5.5
50
nan
SMTNSMTNP53814P53814actincytoskeletonorganizationmuscleorgandevelopmentsmoothmusclecontraction
Thioredoxin-dependent peroxide reductase, mitochondrial
2.0
nan
87
✔
PRDX3PRDX3P35705P35705cellredoxhomeostasiscellularresponsetooxidativestresscellularresponsetoreactiveoxygenspecieshydrogenperoxidecatabolicprocessmaternalplacentadevelopmentmitochondrionorganizationmyeloidcelldifferentiationnegativeregulationofkinaseactivitypeptidyl-cysteineoxidationpositiveregulationofcellpopulationproliferationpositiveregulationofNF-kappaBtranscriptionfactoractivityregulationofmitochondrialmembranepotentialresponsetohydrogenperoxideresponsetolipopolysaccharide
NADH-ubiquinone oxidoreductase chain 6
8.9
99
33
NU6MNU4LMP03925P03903aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisresponsetococaineresponsetohydrogenperoxideresponsetonicotineATPsynthesiscoupledelectrontransport
DNA nucleotidylexotransferase
5.5
60
60
TDTTDTP09838P09838DNAmetabolicprocessDNAmodificationdouble-strandbreakrepairvianonhomologousendjoiningresponsetoATP
Chorionic somatomammotropin hormone
2.0
nan
88
CSHCSHP16038P16038
Defensin-like peptide 1
2.0
48
87
✔
DLP1DLP1P82172P82172
Nuclear receptor subfamily 0 group B member 2
5.1
68
62
NR0B2NR0B2Q62227Q62227animalorganregenerationbileacidandbilesalttransportcircadianregulationofgeneexpressioncircadianrhythmnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIINotchsignalingpathwaypositiveregulationofDNA-templatedtranscriptionpositiveregulationofgeneexpressionpositiveregulationofinsulinsecretionresponsetoethanolresponsetoglucoseresponsetoorganiccycliccompound
Guanine nucleotide exchange protein SMCR8
4.2
96
65
SMCR8SMCR8Q8TEV9Q8TEV9autophagynegativeregulationofautophagosomeassemblynegativeregulationofexocytosisnegativeregulationofgeneexpressionnegativeregulationofimmuneresponsenegativeregulationofmacroautophagynegativeregulationofproteinkinaseactivitypositiveregulationofautophagosomematurationpositiveregulationofGTPaseactivitypositiveregulationofTORsignalingregulationofautophagyregulationofTORC1signaling
Cell division control protein 6 homolog
5.2
67
59
CDC6CDC6Q99741Q99741celldivisioncellularresponsetoangiotensincellularresponsetovasopressinDNAreplicationcheckpointsignalingDNAreplicationinitiationmitoticcellcyclemitoticDNAreplicationcheckpointsignalingnegativeregulationofcellpopulationproliferationnegativeregulationofDNAreplicationpositiveregulationofchromosomesegregationpositiveregulationofcyclin-dependentproteinserine/threoninekinaseactivitypositiveregulationofcytokinesispositiveregulationoffibroblastproliferationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofmitoticmetaphase/anaphasetransitiontraversingstartcontrolpointofmitoticcellcycle
Afadin
4.1
60
78
AFADAFADP55196P55196bicellulartightjunctionassemblycelladhesioncell-celladhesionmediatedbycadherincell-cellsignalingestablishmentofendothelialintestinalbarrierestablishmentofproteinlocalizationtoplasmamembranenegativeregulationofcellmigrationporecomplexassemblypositiveregulationofcell-celladhesionpositiveregulationofcell-celladhesionmediatedbycadherinpositiveregulationofgeneexpressionpositiveregulationofGTPaseactivityregulationofproteinlocalizationsignaltransduction
Voltage-dependent L-type calcium channel subunit alpha-1C
6.5
45
57
CAC1CCAC1CQ13936Q13936calciumionimportacrossplasmamembranecalciumiontransmembranetransportcalciumiontransmembranetransportviahighvoltage-gatedcalciumchannelcalciumiontransportintocytosolcalcium-mediatedsignalingusingextracellularcalciumsourcecamera-typeeyedevelopmentcardiacconductioncardiacmusclecellactionpotentialinvolvedincontractioncellcommunicationbyelectricalcouplinginvolvedincardiacconductionembryonicforelimbmorphogenesisheartdevelopmentimmunesystemdevelopmentmembranedepolarizationduringatrialcardiacmusclecellactionpotentialmembranedepolarizationduringAVnodecellactionpotentialmembranedepolarizationduringcardiacmusclecellactionpotentialpositiveregulationofadenylatecyclaseactivitypositiveregulationofcytosoliccalciumionconcentrationregulationofcardiacmusclecontractionbyregulationofthereleaseofsequesteredcalciumionregulationofheartratebycardiacconductionregulationofventricularcardiacmusclecellactionpotential
Enhancer of polycomb homolog 1
8.8
68
42
EPC1EPC1Q9H2F5Q9H2F5DNA-templatedtranscriptiondouble-strandbreakrepairviahomologousrecombinationhistoneacetylationhistoneH2AacetylationhistoneH4acetylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionepigeneticnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofapoptoticprocessregulationofcellcycleregulationofdouble-strandbreakrepairregulationoftranscriptionbyRNApolymeraseIIspermDNAcondensationspermatiddevelopment
IGH + IGL c465_light_IGLV2-14_IGLJ1
2.0
83
nan
A0A5C2GBJ8A0A5C2GBJ8A0A5C2GBJ8A0A5C2GBJ8
Developmental pluripotency-associated protein 3
3.9
54
80
DPPA3DPPA3Q8QZY3Q8QZY3chromatinorganizationembryoniccleavagenegativeregulationofDNAdemethylationprotectionofDNAdemethylationoffemalepronucleusregulationofgeneticimprinting
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
6.8
94
39
TAB1TAB1Q15750Q15750aortadevelopmentcardiacseptumdevelopmentcoronaryvasculaturedevelopmentheartmorphogenesisinuteroembryonicdevelopmentlungdevelopmentpositiveregulationofMAPkinaseactivitypositiveregulationofproteinserine/threoninekinaseactivitytransforminggrowthfactorbetareceptorsignalingpathway
Defensin-like peptide 2/4
2.0
49
86
DLP2DLP2P82140P82140
Histone deacetylase complex subunit SAP25
8.6
31
54
SAP25SAP25Q1EHW4Q1EHW4regulationofDNA-templatedtranscription
Coiled-coil domain containing 142
9.7
64
37
F1SLH8F1SLH8F1SLH8F1SLH8
Calcium-activated potassium channel subunit beta-2
2.0
61
nan
KCMB2KCMB2Q9Y691Q9Y691actionpotentialdetectionofcalciumionneuronalactionpotentialpotassiumiontransportregulationofvasoconstriction
Cytochrome P450 11B2, mitochondrial
3.9
78
nan
C11B2C11B2P19099P19099aldosteronebiosyntheticprocessC21-steroidhormonebiosyntheticprocesscellularresponsetohormonestimuluscellularresponsetopeptidehormonestimuluscellularresponsetopotassiumioncholesterolmetabolicprocesscortisolbiosyntheticprocesscortisolmetabolicprocessglucocorticoidbiosyntheticprocessmineralocorticoidbiosyntheticprocesspotassiumionhomeostasisregulationofbloodvolumebyrenalaldosteronerenalwaterhomeostasissodiumionhomeostasissterolmetabolicprocess
Mastermind-like protein 1
4.0
73
76
SUHMAML1Q06330Q92585angiogenesisaorticvalvedevelopmentarterialendothelialcellfatecommitmentatrioventricularcanaldevelopmentauditoryreceptorcellfatecommitmentBcelldifferentiationbloodvesselendothelialcellfatespecificationbloodvessellumenizationbloodvesselremodelingcardiacleftventriclemorphogenesiscardiacmusclecellmyoblastdifferentiationclubcelldifferentiationdefenseresponsetobacteriumdorsalaortamorphogenesisendocardiummorphogenesisepidermalcellfatespecificationepithelialcellproliferationepithelialtomesenchymaltransitionepithelialtomesenchymaltransitioninvolvedinendocardialcushionformationhairfolliclematurationhumoralimmuneresponseinflammatoryresponsetoantigenicstimuluskeratinocytedifferentiationlabyrinthinelayerbloodvesseldevelopmentmyeloiddendriticcelldifferentiationnegativeregulationofcelldifferentiationnegativeregulationofcold-inducedthermogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofossificationnegativeregulationofstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIINotchsignalinginvolvedinheartdevelopmentNotchsignalingpathwayoutflowtractmorphogenesispituitaryglanddevelopmentpositiveregulationofBMPsignalingpathwaypositiveregulationofcanonicalWntsignalingpathwayinvolvedincardiacmusclecellfatecommitmentpositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellproliferationinvolvedinheartmorphogenesispositiveregulationofephrinreceptorsignalingpathwaypositiveregulationofepithelialcellproliferationpositiveregulationofERBBsignalingpathwaypositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetohypoxiapositiveregulationoftranscriptionofNotchreceptortargetpulmonaryvalvedevelopmentregulationofreproductiveprocessregulationoftimingofcelldifferentiationregulationoftranscriptionbyRNApolymeraseIIsebaceousglanddevelopmentsecondaryheartfieldspecificationsomaticstemcellpopulationmaintenancesomitogenesisstemcellproliferationventricularseptummorphogenesisventriculartrabeculamyocardiummorphogenesisatrioventricularnodecelldevelopmentatrioventricularnodedevelopmentmyoblastdifferentiationpositiveregulationofmyotubedifferentiationproteinphosphorylation
Trichosurin
2.0
nan
91
TRICTRICQ29147Q29147
Tudor domain-containing protein 3
8.3
70
nan
TDRD3TDRD3Q9H7E2Q9H7E2chromatinorganizationDNAtopologicalchange
ADP-ribosylation factor-like protein 2
8.7
65
44
ARL2ARL2Q9D0J4Q9D0J4acetylcholinetransportbicellulartightjunctionassemblycentrosomecyclemaintenanceofproteinlocationinnucleusnegativeregulationofGTPaseactivitypositiveregulationofcell-substrateadhesionpositiveregulationofmicrotubulepolymerizationproteinfoldingregulationofaerobicrespirationregulationofglycolyticprocessregulationofmicrotubulepolymerization
T-cell receptor alpha chain V region PHDS58
5.8
nan
77
TVA1TCB1P01738P01852adaptiveimmuneresponseBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Ig lambda-1 chain V region H2020
2.1
85
79
LV1DLV1DP01726P01726adaptiveimmuneresponseimmuneresponse
Cip1-interacting zinc finger protein
4.8
70
68
CIZ1CIZ1Q9ULV3Q9ULV3maintenanceofproteinlocationinnucleuspositiveregulationofDNA-templatedDNAreplicationinitiation
Salivary lipocalin
2.0
51
85
SALSALP81608P81608
Nuclear receptor coactivator 2
7.7
77
nan
NCOA2NCOA2Q15596Q15596cellularresponsetohormonestimuluscellularresponsetoThyroglobulintriiodothyroninecircadianregulationofgeneexpressionlocomotorrhythmmRNAtranscriptionbyRNApolymeraseIInegativeregulationoftranscriptionbyRNApolymeraseIIperoxisomeproliferatoractivatedreceptorsignalingpathwaypositiveregulationofadiposetissuedevelopmentpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellularresponsetoinsulinstimulusregulationofDNA-templatedtranscriptionregulationofglucosemetabolicprocessregulationoflipidmetabolicprocessresponsetoprogesterone
Protein CBFA2T2
8.2
61
nan
MTG8RMTG8RO70374O70374epithelialcelldifferentiationintestinalepithelialcelldifferentiationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofneuronprojectiondevelopmentnegativeregulationofNotchsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofneuronprojectiondevelopment
T-cell receptor beta chain V region E1
2.0
87
79
TVB6TVB6P04214P04214adaptiveimmuneresponse
CD48 antigen
2.0
79
nan
CD48CD48P10252P10252mastcellactivationsignaltransductionTcellactivation
CCAAT/enhancer-binding protein epsilon
3.9
48
nan
CEBPECEBPEQ15744Q15744cellularresponsetolipopolysaccharidedefenseresponsegranulocytedifferentiationintegratedstressresponsesignalingmacrophagedifferentiationmyeloidcelldifferentiationphagocytosispositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseII
Prostaglandin-E(2) 9-reductase
9.1
79
32
PE2RPE2RP80508P80508prostaglandinbiosyntheticprocess
Myocardial zonula adherens protein
9.5
62
nan
MYZAPMYZAPD2E9U7D2E9U7intracellularsignaltransduction
Poly(U)-binding-splicing factor PUF60
2.1
72
nan
PUF60PUF60Q9UHX1Q9UHX1alternativemRNAsplicingviaspliceosomeapoptoticprocessmRNAsplicesiteselectionregulationofalternativemRNAsplicingviaspliceosome
B-cell CLL/lymphoma 9-like protein
3.8
47
nan
BCL9LBCL9LQ86UU0Q86UU0canonicalWntsignalingpathwaymyoblastdifferentiationnegativeregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofepithelialtomesenchymaltransitionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellmorphogenesisskeletalmusclecelldifferentiationsomaticstemcellpopulationmaintenancetranscriptionbyRNApolymeraseII
Polyglutamine-binding protein 1
3.6
67
nan
✔
PQBP1PQBP1O60828O60828activationofinnateimmuneresponsealternativemRNAsplicingviaspliceosomecellularresponsetoexogenousdsRNAdefenseresponsetovirusinnateimmuneresponseneuronprojectiondevelopmentpositiveregulationofdefenseresponsetovirusbyhostpositiveregulationoftypeIinterferonproductionregulationofdendritemorphogenesisregulationofDNA-templatedtranscriptionregulationofRNAsplicing
SPRY domain-containing SOCS box protein 2
8.2
64
41
SPSB2SPSB2O88838O88838intracellularsignaltransductionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinubiquitinationubiquitin-dependentproteincatabolicprocess
SH2B adapter protein 1
8.0
66
nan
SH2B1SH2B1Q9WVM5Q9WVM5intracellularsignaltransductionlamellipodiumassemblypositiveregulationofmitoticnucleardivisionpositiveregulationofSMADproteinsignaltransductionregulationofDNAbiosyntheticprocess
SH2B adapter protein 2
8.4
46
47
SH2B2SH2B2Q9Z200Q9Z200actincytoskeletonorganizationantigenreceptor-mediatedsignalingpathwayBcellreceptorsignalingpathwayB-1Bcellhomeostasisbrownfatcelldifferentiationcytokine-mediatedsignalingpathwayinsulinreceptorsignalingpathwayintracellularsignaltransductionnervoussystemdevelopmentregulationofimmuneresponseregulationofmetabolicprocessregulationofRasproteinsignaltransductiontransmembranereceptorproteintyrosinekinasesignalingpathway
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
7.5
28
60
PDE4APDE4AP54748P54748cAMPcatabolicprocesscellularresponsetoxenobioticstimulusmodulationofchemicalsynaptictransmissionregulationofadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayregulationofproteinkinaseAsignalingresponsetoxenobioticstimulussensoryperceptionofsmellsignaltransduction
Major seminal plasma glycoprotein PSP-II
2.0
46
87
PSP2PSP2P35496P35496singlefertilization
Mannose-binding protein A
2.0
68
82
MBL1MBL1P19999P19999complementactivationclassicalpathwaycomplementactivationlectinpathwaydefenseresponsetoGram-positivebacteriumkillingbyhostofsymbiontcellspositiveregulationofphagocytosisproteinhomotrimerization
peptidylprolyl isomerase
5.2
66
nan
Q0VDC6Q0VDC6Q0VDC6Q0VDC6
ELAV-like protein 1
2.2
68
nan
ELAV1ELAV1Q15717Q15717"3-UTR-mediatedmRNAstabilization"mRNAstabilizationnegativeregulationofmiRNA-mediatedgenesilencingpositiveregulationoftranslationpost-transcriptionalgenesilencingproteinhomooligomerizationproteinimportintonucleusregulationofstemcellpopulationmaintenance
Forkhead box protein H1
2.0
51
nan
FOXH1FOXH1O75593O75593aortamorphogenesisaxialmesodermdevelopmentcardiacrightventriclemorphogenesiscellularresponsetocytokinestimulusembryonichearttubeanterior/posteriorpatternspecificationheartloopingnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofintracellularestrogenreceptorsignalingpathwaynegativeregulationoftranscriptionbyRNApolymeraseIInodalsignalingpathwayinvolvedindeterminationoflateralmesodermleft/rightasymmetryoutflowtractmorphogenesispositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionbyRNApolymeraseIIsecondaryheartfieldspecificationtransforminggrowthfactorbetareceptorsignalingpathwayventriculartrabeculamyocardiummorphogenesis
Ferritin light chain
7.2
61
49
FRILFRILP02791P02791intracellularsequesteringofironionironiontransport
Evasin-1
8.2
61
47
EVA1CCL3P0C8E7P10147negativeregulationofchemokineactivityastrocytecellmigrationcalciumiontransportcalcium-mediatedsignalingcellactivationcell-cellsignalingcellularcalciumionhomeostasiscellularresponsetointerleukin-1cellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxiscytoskeletonorganizationeosinophilchemotaxiseosinophildegranulationexocytosisGprotein-coupledreceptorsignalingpathwaygranulocytechemotaxisinflammatoryresponselipopolysaccharide-mediatedsignalingpathwaylymphocytechemotaxismacrophagechemotaxisMAPKcascademonocytechemotaxisnegativeregulationbyhostofviraltranscriptionnegativeregulationofbonemineralizationnegativeregulationofgeneexpressionnegativeregulationofosteoclastdifferentiationneutrophilchemotaxisosteoblastdifferentiationpositiveregulationofcalciumionimportpositiveregulationofcalciumiontransportpositiveregulationofcalcium-mediatedsignalingpositiveregulationofcellmigrationpositiveregulationofERK1andERK2cascadepositiveregulationofgeneexpressionpositiveregulationofGTPaseactivitypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofmicroglialcellactivationpositiveregulationofmicroglialcellmigrationpositiveregulationofnaturalkillercellchemotaxispositiveregulationofneuronapoptoticprocesspositiveregulationofproteinkinaseBsignalingpositiveregulationoftumornecrosisfactorproductionproteinkinaseBsignalingregulationofbehaviorregulationofcellshaperegulationofsensoryperceptionofpainreleaseofsequesteredcalciumionintocytosolbysarcoplasmicreticulumresponsetocholesterolresponsetotoxicsubstancesignalingTcellchemotaxis
Proteasome subunit beta type-5
7.2
69
45
PSB5PSB5O55234O55234proteasomalproteincatabolicprocessproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteolysisresponsetooxidativestress
Antigen peptide transporter 1
3.2
53
79
TAP1TAP1P36370P36370adaptiveimmuneresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIcytosoltoendoplasmicreticulumtransportdefenseresponsepeptideantigentransportpeptidetransportprotectionfromnaturalkillercellmediatedcytotoxicityproteintransporttransmembranetransport
CCAAT/enhancer-binding protein alpha
7.6
56
51
CEBPACEBPAP49715P49715brownfatcelldifferentiationcellularresponsetolithiumioncellularresponsetoorganiccycliccompoundcellularresponsetotumornecrosisfactorcholesterolmetabolicprocesscytokine-mediatedsignalingpathwayembryonicplacentadevelopmentepithelialcellmaturationfatcelldifferentiationgenerationofprecursormetabolitesandenergyglucosehomeostasisgranulocytedifferentiationhematopoieticstemcellproliferationinnereardevelopmentintegratedstressresponsesignalinginterleukin-6-mediatedsignalingpathwaylipidhomeostasisliverdevelopmentlungdevelopmentmacrophagedifferentiationmitochondrionorganizationmyeloidcelldifferentiationnegativeregulationofcellpopulationproliferationnegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofhematopoieticstemcellproliferationnegativeregulationoftranscriptionbyRNApolymeraseIINotchsignalingpathwaypositiveregulationofDNA-templatedtranscriptioninitiationpositiveregulationoffatcelldifferentiationpositiveregulationofgeneexpressionpositiveregulationofinflammatoryresponsepositiveregulationofmacrophageactivationpositiveregulationofosteoblastdifferentiationpositiveregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationoftranscriptionbyRNApolymeraseIIregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIureacyclewhitefatcelldifferentiation
Tumor necrosis factor ligand superfamily member 9
2.0
40
86
TNFL9TNFL9P41274P41274immuneresponsemyeloiddendriticcelldifferentiationpositiveregulationofactivatedTcellproliferationpositiveregulationofcytotoxicTcelldifferentiationpositiveregulationofinterleukin-12productionpositiveregulationofinterleukin-6productionpositiveregulationoftypeIIinterferonproductionregulationofimmatureTcellproliferationinthymus
Twinfilin-1
8.8
81
36
TWF1TWF1Q91YR1Q91YR1actinfilamentdepolymerizationbarbed-endactinfilamentcappingnegativeregulationofactinfilamentpolymerizationpositiveregulationofcardiacmusclehypertrophypositiveregulationofneuronprojectiondevelopmentregulationofactinphosphorylationregulationoflamellipodiumassemblysequesteringofactinmonomers
Gamma-glutamylaminecyclotransferase
5.7
63
61
GGACTGGACTQ923B0Q923B0cellularmodifiedaminoacidcatabolicprocess
Transcriptional coactivator YAP1
2.0
49
nan
YAP1YAP1P46937P46937budelongationinvolvedinlungbranchingcanonicalWntsignalingpathwaycardiacmuscletissueregenerationcellmorphogenesiscellpopulationproliferationcellularresponsetoDNAdamagestimuluscellularresponsetogammaradiationcellularresponsetoretinoicacidcontactinhibitionembryonichearttubemorphogenesisenterocytedifferentiationepithelialcellproliferationextrinsicapoptoticsignalingpathwayglandularepithelialcelldifferentiationheartprocesshipposignalinginterleukin-6-mediatedsignalingpathwayintestinalepithelialcelldevelopmentkeratinocytedifferentiationlateralmesodermdevelopmentlungepithelialcelldifferentiationnegativeregulationofciliumassemblynegativeregulationofepithelialcellapoptoticprocessnegativeregulationofepithelialcelldifferentiationnegativeregulationofextrinsicapoptoticsignalingpathwaynegativeregulationoffatcelldifferentiationnegativeregulationofgeneexpressionnegativeregulationofstemcelldifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIInotochorddevelopmentorgangrowthparaxialmesodermdevelopmentpositiveregulationofcanonicalWntsignalingpathwaypositiveregulationofcardiacmusclecellproliferationpositiveregulationofcellgrowthpositiveregulationofDNA-templatedtranscriptionpositiveregulationofepithelialcellproliferationpositiveregulationofgeneexpressionpositiveregulationofintracellularestrogenreceptorsignalingpathwaypositiveregulationofNotchsignalingpathwaypositiveregulationofosteoblastdifferentiationpositiveregulationofproteinlocalizationtonucleuspositiveregulationofstemcellpopulationmaintenancepositiveregulationoftranscriptionbyRNApolymeraseIIprogesteronereceptorsignalingpathwayprotein-containingcomplexassemblyregulationofkeratinocyteproliferationregulationofmetanephricnephrontubuleepithelialcelldifferentiationregulationofneurogenesisregulationofstemcellproliferationresponsetoprogesteronesomaticstemcellpopulationmaintenancetissuehomeostasistrophectodermalcelldifferentiationvasculogenesiswoundhealing
SRSF protein kinase 1
8.0
nan
nan
SRPK1SRPK1Q96SB4Q96SB4chromosomesegregationinnateimmuneresponseintracellularsignaltransductionnegativeregulationofviralgenomereplicationpositiveregulationofviralgenomereplicationproteinphosphorylationregulationofmRNAprocessingregulationofmRNAsplicingviaspliceosomeRNAsplicingspermDNAcondensationspliceosomalcomplexassembly
55 kDa erythrocyte membrane protein
9.3
72
nan
✔
EM55EM55Q00013Q00013regulationofneutrophilchemotaxissignaltransduction
Polyubiquitin-B
2.0
nan
88
UBE2SUBBQ16763P0CG47anaphase-promotingcomplex-dependentcatabolicprocesscelldivisionexitfrommitosisfreeubiquitinchainpolymerizationpositiveregulationofubiquitinproteinligaseactivityproteinK11-linkedubiquitinationproteinK27-linkedubiquitinationproteinK29-linkedubiquitinationproteinK6-linkedubiquitinationproteinK63-linkedubiquitinationproteinmodificationprocessproteinpolyubiquitinationubiquitin-dependentproteincatabolicprocessenergyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopment
Natural killer cell receptor 2B4
6.2
nan
64
CD244CD244Q07763Q07763adaptiveimmuneresponseinnateimmuneresponsemyeloiddendriticcellactivationnaturalkillercellactivationinvolvedinimmuneresponsepositiveregulationofCD8-positivealpha-betaTcellproliferationpositiveregulationofgranzymeBproductionpositiveregulationofinositolphosphatebiosyntheticprocesspositiveregulationofinterleukin-8productionpositiveregulationofnaturalkillercellproliferationpositiveregulationoftypeIIinterferonproduction
Signal recognition particle 14 kDa protein
8.6
62
nan
SRP14SRP14P16254P16254proteintargetingtoERSRP-dependentcotranslationalproteintargetingtomembrane
Plasminogen activator inhibitor 1
2.0
64
nan
PAI1PAI1P05121P05121angiogenesiscellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdentinogenesisfibrinolysisnegativeregulationofbloodcoagulationnegativeregulationofcelladhesionmediatedbyintegrinnegativeregulationofcellmigrationnegativeregulationofendopeptidaseactivitynegativeregulationofendothelialcellapoptoticprocessnegativeregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsnegativeregulationoffibrinolysisnegativeregulationofplasminogenactivationnegativeregulationofsmoothmusclecellmigrationnegativeregulationofsmoothmusclecell-matrixadhesionnegativeregulationofvascularwoundhealingnegativeregulationofwoundhealingpositiveregulationofangiogenesispositiveregulationofbloodcoagulationpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-8productionpositiveregulationofleukotrieneproductioninvolvedininflammatoryresponsepositiveregulationofmonocytechemotaxispositiveregulationofodontoblastdifferentiationpositiveregulationofreceptor-mediatedendocytosisregulationofsignalingreceptoractivityreplicativesenescence
Oxidized purine nucleoside triphosphate hydrolase
2.0
89
80
8ODP8ODPP53368P53368agingDNAprotectionmalegonaddevelopmentpurinenucleosidecatabolicprocessresponsetocadmiumion
Chromogranin-A
2.0
nan
nan
CMGACMGAP05059P05059adenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedincardiacmusclerelaxationantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetobacteriumdefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdisruptionbyhostofsymbiontcellwallinnateimmuneresponsekillingofcellsofanotherorganismmastcellactivationmastcellchemotaxismastcelldegranulationnegativeregulationofangiogenesisnegativeregulationofcatecholaminesecretionnegativeregulationofhormonesecretionnegativeregulationofinsulinsecretionpositiveregulationofdensecoregranulebiogenesisregulationofcelladhesion
Hsp90 co-chaperone Cdc37
9.3
71
nan
K7EJ06K7EJ06K7EJ06K7EJ06
Enhanced green fluorescent protein
4.4
39
nan
A0A7G8ZY66UNC80A0A7G8ZY66Q8N2C7bioluminescencegenerationofprecursormetabolitesandenergycationhomeostasis
Interferon-inducible protein AIM2
2.0
55
86
✔
AIM2AIM2Q91VJ1Q91VJ1activationofinnateimmuneresponseapoptoticprocesscellularresponsetointerferon-betacellularresponsetoxenobioticstimulusdefenseresponsetovirusinflammatoryresponseinnateimmuneresponsenegativeregulationofNF-kappaBtranscriptionfactoractivityNLRP3inflammasomecomplexassemblypatternrecognitionreceptorsignalingpathwaypositiveregulationofcysteine-typeendopeptidaseactivitypositiveregulationofdefenseresponsetovirusbyhostpositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofNF-kappaBtranscriptionfactoractivitypyroptosispyroptosomecomplexassemblytumornecrosisfactor-mediatedsignalingpathway
Selenoprotein W
10.0
40
45
SELWSELWP63300P63300responsetoseleniumion
Arfaptin-2
2.0
52
nan
ARFP2ARFP2P53365P53365actincytoskeletonorganizationintracellularproteintransportlamellipodiumassemblymitophagyproteinlocalizationtophagophoreassemblysiteregulationofArp2/3complex-mediatedactinnucleationruffleorganizationsmallGTPasemediatedsignaltransduction
Carbonic anhydrase 2
2.1
63
nan
CAH2CAH2P00918P00918angiotensin-activatedsignalingpathwaycarbondioxidetransportmorphogenesisofanepitheliumneuroncellularhomeostasisone-carbonmetabolicprocesspositiveregulationofcellularpHreductionpositiveregulationofdipeptidetransmembranetransportpositiveregulationofsynaptictransmissionGABAergicregulationofaniontransportregulationofchloridetransportregulationofintracellularpHsecretion
Cytochrome c oxidase subunit 1
3.9
94
nan
COX1COX1Q6EMS9Q6EMS9oxidativephosphorylation
N-acetyllactosaminide alpha-1,3-galactosyltransferase
10.0
82
25
GGTA1GGTA1P14769P14769carbohydratemetabolicprocesslipidglycosylationproteinglycosylation
Ig kappa-b4 chain C region
2.0
nan
88
KAC4A0A1Y1B8B1P01840A0A1Y1B8B1
Green fluorescent protein
4.7
70
65
GFPCD3EP42212P07766bioluminescencegenerationofprecursormetabolitesandenergyadaptiveimmuneresponsealpha-betaTcellactivationapoptoticsignalingpathwaycalcium-mediatedsignalingCD4-positivealpha-betaTcellproliferationcellsurfacereceptorsignalingpathwaycerebellumdevelopmentdendritedevelopmentGprotein-coupledreceptorsignalingpathwaygamma-deltaTcellactivationnegativeregulationofgeneexpressionnegativeregulationofsmoothenedsignalingpathwaynegativethymicTcellselectionpeptidyl-tyrosinephosphorylationpositiveregulationofcalcium-mediatedsignalingpositiveregulationofCD4-positivealpha-betaTcellproliferationpositiveregulationofcell-celladhesionmediatedbyintegrinpositiveregulationofcell-matrixadhesionpositiveregulationofgeneexpressionpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofTcellanergypositiveregulationofTcellproliferationpositiveregulationoftypeIIinterferonproductionpositivethymicTcellselectionprotein-containingcomplexassemblyregulationofapoptoticprocesssignalcomplexassemblysmoothenedsignalingpathwayTcellactivationTcellanergyTcellcostimulationTcellreceptorsignalingpathwaytransmembranereceptorproteintyrosinekinasesignalingpathway
Early 35 kDa protein
6.3
nan
58
✔
P35CASP8P08160Q14790negativeregulationofapoptoticprocessnegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesssuppressionbyvirusofhostapoptoticprocesssuppressionofhostRNAi-mediatedantiviralimmuneresponseactivationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessangiogenesisapoptoticprocessapoptoticsignalingpathwayBcellactivationcellularresponsetomechanicalstimuluscellularresponsetoorganiccycliccompoundexecutionphaseofapoptosisextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsheartdevelopmentmacrophagedifferentiationnaturalkillercellactivationnegativeregulationofI-kappaBkinase/NF-kappaBsignalingnegativeregulationofnecroptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofinterleukin-1betaproductionpositiveregulationofmacrophagedifferentiationpositiveregulationofneurondeathpositiveregulationofproteolysisproteolysisproteolysisinvolvedinproteincatabolicprocesspyroptosisregulationofcytokineproductionregulationofinnateimmuneresponseregulationoftumornecrosisfactor-mediatedsignalingpathwayresponsetoantibioticresponsetocobaltionresponsetocoldresponsetoestradiolresponsetoethanolresponsetolipopolysaccharideresponsetotumornecrosisfactorselfproteolysissyncytiotrophoblastcelldifferentiationinvolvedinlabyrinthinelayerdevelopmentTcellactivationTRAIL-activatedapoptoticsignalingpathway
Evasin P974
7.0
78
50
EV974CCL17A0A023FDY8Q92583negativeregulationofchemokineactivityantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecell-cellsignalingcellularresponsetointerleukin-1cellularresponsetotumornecrosisfactorcellularresponsetotypeIIinterferonchemokine-mediatedsignalingpathwaychemotaxisGprotein-coupledreceptorsignalingpathwayinflammatoryresponsekillingofcellsofanotherorganismlymphocytechemotaxismonocytechemotaxisnegativeregulationofmyoblastdifferentiationneutrophilchemotaxispositiveregulationofERK1andERK2cascadepositiveregulationofGTPaseactivity
Aly/REF export factor 2
7.4
34
60
ALRF2Q9J0X9Q9JJW6Q9J0X9mRNAexportfromnucleusmRNAprocessingmRNAtransportpositiveregulationofDNA-templatedtranscriptionelongationregulationofDNArecombinationreplicationforkprocessingRNAexportfromnucleusRNAsplicingviralmRNAexportfromhostcellnucleusproteinexportfromnucleusregulationofDNA-templatedtranscription
Cytochrome c isoform 1
9.5
57
45
CYC1ADXP00044P00257mitochondrialelectrontransportcytochromectooxygenmitochondrialelectrontransportubiquinoltocytochromeccellularresponsetocAMPcellularresponsetoforskolincholesterolmetabolicprocesselectrontransportchainhormonebiosyntheticprocessP450-containingelectrontransportchainpositiveregulationofoxidoreductaseactivityrespiratoryelectrontransportchainsteroidbiosyntheticprocess
Ecotin
7.9
82
45
FA10ECOTP00742P23827bloodcoagulationbloodcoagulationcommonpathwaypositiveregulationofcellmigrationpositiveregulationofproteinkinaseBsignalingproteolysiszymogenactivationnegativeregulationofpeptidaseactivity
Large T antigen
9.4
79
38
LTRBP03070P06400bidirectionaldouble-strandedviralDNAreplicationDNAunwindinginvolvedinDNAreplicationmodulationbyvirusofhostG1/StransitioncheckpointmodulationbyvirusofhostproteinubiquitinationsuppressionbyvirusofhostJAK-STATcascadeviainhibitionofJAK1activitysuppressionbyvirusofhosttypeIinterferon-mediatedsignalingpathwayviralDNAgenomereplicationaorticvalvemorphogenesiscelldifferentiationcelldivisioncellmorphogenesisinvolvedinneurondifferentiationcellularresponsetoinsulinstimuluscellularresponsetoxenobioticstimuluschondrocytedifferentiationchromatinremodelingchromosomeorganizationdigestivetractdevelopmentenucleateerythrocytedifferentiationepithelialcellproliferationglialcellapoptoticprocessglialcellproliferationhepatocyteapoptoticprocessheterochromatinformationmaintenanceofmitoticsisterchromatidcohesionmyoblastdifferentiationnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcellcyclenegativeregulationofcellgrowthnegativeregulationofcold-inducedthermogenesisnegativeregulationofDNA-bindingtranscriptionfactoractivitynegativeregulationofDNA-templatedtranscriptionnegativeregulationofepithelialcellproliferationnegativeregulationofG1/Stransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationofglialcellproliferationnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofinflammatoryresponsenegativeregulationofmyofibroblastdifferentiationnegativeregulationofproteinkinaseactivitynegativeregulationofproteinserine/threoninekinaseactivitynegativeregulationofsmoothenedsignalingpathwaynegativeregulationoftau-proteinkinaseactivitynegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationoftranscriptioninvolvedinG1/Stransitionofmitoticcellcycleneuronapoptoticprocessneuronmaturationneuronprojectiondevelopmentpositiveregulationofcollagenfibrilorganizationpositiveregulationofextracellularmatrixorganizationpositiveregulationofmacrophagedifferentiationpositiveregulationofmitoticmetaphase/anaphasetransitionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionregulatoryregionDNAbindingproteinlocalizationtochromosomecentromericregionRasproteinsignaltransductionregulationofcellcycleregulationofcentromerecomplexassemblyregulationofDNA-templatedtranscriptionregulationoflipidkinaseactivityregulationofmitoticcellcyclesisterchromatidbiorientationskeletalmusclecelldifferentiationsmoothenedsignalingpathwayspermatogenesisstriatedmusclecelldifferentiationtissuehomeostasistranscriptionbyRNApolymeraseII
Secreted effector protein SptP
9.5
66
36
SPTPRAC1P74873P63000proteindephosphorylationactincytoskeletonorganizationactinfilamentorganizationactinfilamentpolymerizationanatomicalstructuremorphogenesiscelladhesioncellmigrationcellmotilitycellprojectionassemblycell-matrixadhesioncorticalcytoskeletonorganizationengulfmentofapoptoticcellestablishmentormaintenanceofcellpolarityhepatocytegrowthfactorreceptorsignalingpathwayinflammatoryresponseintracellularsignaltransductionlamellipodiumassemblylocalizationlocalizationwithinmembranemotorneuronaxonguidancenegativeregulationoffibroblastmigrationnegativeregulationofinterleukin-23productionnegativeregulationofreceptor-mediatedendocytosisneuronmigrationpositiveregulationofcell-substrateadhesionpositiveregulationofendothelialcellmigrationpositiveregulationoffocaladhesionassemblypositiveregulationoflamellipodiumassemblypositiveregulationofmicrotubulepolymerizationpositiveregulationofneutrophilchemotaxispositiveregulationofproteinphosphorylationpositiveregulationofRhoproteinsignaltransductionpositiveregulationofstressfiberassemblypositiveregulationofsubstrateadhesion-dependentcellspreadingRacproteinsignaltransductionregulationofactincytoskeletonorganizationregulationofcellmigrationregulationofcellshaperegulationofcellsizeregulationofhydrogenperoxidemetabolicprocessregulationoflamellipodiumassemblyregulationofneutrophilmigrationregulationofnitricoxidebiosyntheticprocessregulationofrespiratoryburstregulationofstressfiberassemblyrespiratoryburstresponsetowoundingruffleassemblyruffleorganizationsemaphorin-plexinsignalingpathwaysmallGTPasemediatedsignaltransductionsphingosine-1-phosphatereceptorsignalingpathwaysubstrateadhesion-dependentcellspreadingWntsignalingpathwayplanarcellpolaritypathway
Yellow fluorescent protein
2.0
77
78
LUXYCD79BP21578P15530bioluminescenceadaptiveimmuneresponseBcelldifferentiationBcellreceptorsignalingpathwayresponsetobacterium
Cation channel sperm-associated auxiliary subunit gamma 2
1.8
60
87
CTSG2CTSG2C6KI89C6KI89celldifferentiationspermatogenesis
Killer cell lectin-like receptor 3
1.9
76
83
KLRA3KLRA3Q61198Q61198celladhesion
Alpha-defensin 1
1.9
50
84
DEFA1DEFA1A6YB85A6YB85antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosa
Ig heavy chain V region M603
1.9
nan
nan
HVM20HVM20P01789P01789BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Venom-like beta-defensin
2.0
53
86
DEFBLDEFBLP0C8B1P0C8B1defenseresponsetobacterium
Immunoglobulin heavy constant gamma 2B
2.0
80
nan
IGG2BIGG2BP01867P01867BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriumhumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunoglobulinmediatedimmuneresponseinnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationpositiveregulationofimmuneresponsepositiveregulationofphagocytosispositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIahypersensitivity
Ribonuclease pancreatic beta-type
2.0
52
87
RNS1BRNS1BP00684P00684defenseresponsetoGram-positivebacteriumresponsetobacteriumRNAphosphodiesterbondhydrolysis
Lysozyme C-2
2.0
74
84
LYZ2LYZ2P08905P08905cytolysisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumkillingofcellsofanotherorganismmetabolicprocess
H-2 class II histocompatibility antigen, A-D beta chain
2.0
87
80
HB2DHB2DP01921P01921adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigenimmuneresponsepeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
Killer cell lectin-like receptor subfamily B member 1B allele A
2.0
70
84
KRBBAKRBBAA4KWA1A4KWA1regulationofnaturalkillercellmediatedcytotoxicity
Mast cell protease 2
2.0
76
82
MCPT2MCPT2P00770P00770proteolysis
Major urinary protein 20
2.0
52
85
MUP20MUP20Q5FW60Q5FW60olfactorylearningpositiveregulationofneuralprecursorcellproliferationpositiveregulationofneurogenesisvocalizationbehavior
Aldo-keto reductase family 1 member C21
2.0
63
84
AK1CLAK1CLQ6P8V0Q6P8V0daunorubicinmetabolicprocessdoxorubicinmetabolicprocessprogesteronemetabolicprocessprostaglandinmetabolicprocesssteroidbiosyntheticprocesssteroidmetabolicprocess
Interleukin-3 receptor class 2 subunit beta
2.0
56
88
IL3B2IL3B2P26954P26954cytokine-mediatedsignalingpathwaygranulocyte-macrophagecolony-stimulatingfactorsignalingpathwayimmunoglobulinmediatedimmuneresponsepositiveregulationofleukocyteproliferationproteinphosphorylationreceptorsignalingpathwayviaJAK-STAT
Lysozyme C, milk isozyme
2.0
74
85
LYSC1LYSC1P11376P11376cytolysisdefenseresponsetobacteriummetabolicprocess
Pepsin A
2.0
60
89
PEPAPEPAP00791P00791digestionproteolysis
CD209 antigen-like protein B
2.0
75
83
C209BC209BQ8CJ91Q8CJ91BcelladhesiondetectionofbacteriumdetectionofyeastendocytosisphagocytosisrecognitionpositiveregulationofphagocytosispositiveregulationofTcellproliferationpositiveregulationoftumornecrosisfactorproductionpositiveregulationofvirallifecycleviralentryintohostcell
Chymosin
2.0
63
88
CHYMCHYMP00794P00794digestionproteolysis
Ig heavy chain V region PJ14
2.0
85
82
HVM44HVM44P01820P01820BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
T-cell receptor beta-2 chain C region
2.0
89
81
TCB2TCB2P01851P01851BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Acylcarnitine hydrolase
2.0
82
81
EST2CEST2CQ91WG0Q91WG0prostaglandinmetabolicprocessresponsetobileacid
Killer cell lectin-like receptor subfamily B member 1A
2.0
74
84
KLRBAKLRBAP27811P27811regulationofnaturalkillercellmediatedcytotoxicity
Antigen-presenting glycoprotein CD1d2
2.0
83
80
CD1D2CD1D2P11610P11610antigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbinnateimmuneresponsepositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofNKTcellactivationpositiveregulationofTcellmediatedcytotoxicity
Epididymal-specific lipocalin-5
2.0
62
84
LCN5LCN5P06911P06911
Ig kappa chain V-V region MOPC 21
2.0
91
79
KV5A2KV5A2P01634P01634adaptiveimmuneresponseimmuneresponse
Antimicrobial peptide NK-lysin
2.0
69
84
NKLNKLQ29075Q29075antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetobacteriumdefenseresponsetofunguskillingofcellsofanotherorganismlipidmetabolicprocess
Ig gamma-2A chain C region, A allele
2.0
30
89
GCAAGCAAP01863P01863BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationresponsetobacterium
Corticostatin-related peptide RK-1
2.0
48
88
RK1RK1P81655P81655defenseresponsetobacterium
Angiogenin-1
2.0
79
84
ANG1ANG1P10152P10152actinfilamentpolymerizationactivationofphospholipaseA2activityactivationofphospholipaseCactivityangiogenesisantibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecelldifferentiationdefenseresponsetoGram-positivebacteriumdiacylglycerolbiosyntheticprocessinnateimmuneresponsenegativeregulationofsmoothmusclecellproliferationnegativeregulationoftranslationovarianfollicledevelopmentpositiveregulationofendothelialcellproliferationpositiveregulationofproteinsecretionresponsetohypoxiarRNAtranscription
Epidermal growth factor-binding protein type B
2.0
78
81
EGFB2EGFB2P36368P36368regulationofsystemicarterialbloodpressurezymogenactivation
Protegrin-4
2.0
48
86
PG4PG4P49933P49933antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Ig gamma-2A chain C region, membrane-bound form
3.0
nan
89
IGKCGCAMP01837P01865BcelldifferentiationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationantibody-dependentcellularcytotoxicityantigenprocessingandpresentationearlyendosometolateendosometransportendosometolysosometransporthumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunoglobulinmediatedimmuneresponsepositiveregulationofendocytosispositiveregulationofimmuneresponsepositiveregulationofphagocytosispositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIahypersensitivityregulationofproteolysis
Ig gamma-2A chain C region secreted form
2.0
81
81
GCABGCABP01864P01864regulationofimmuneresponse
Salivary plasminogen activator alpha 1
2.0
89
80
URT1URT1P98119P98119plasminogenactivation
Pancreatic trypsin inhibitor
2.0
60
87
BPT1BPT1P00974P00974negativeregulationofplateletaggregationnegativeregulationofserine-typeendopeptidaseactivitynegativeregulationofthrombin-activatedreceptorsignalingpathwaytrypsinogenactivation
Ig heavy chain V region J539
2.0
66
nan
HVM40HVM40P01810P01810BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Major urinary protein 6
2.0
38
90
MUP6MUP6P02762P02762aerobicrespirationcellularresponsetolipidenergyreservemetabolicprocessglucosehomeostasisheatgenerationlocomotorrhythmmitochondrionmorphogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgluconeogenesisnegativeregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusnegativeregulationoflipidbiosyntheticprocessnegativeregulationoflipidstoragepositiveregulationofgeneexpressionpositiveregulationofglucosemetabolicprocesspositiveregulationoflipidmetabolicprocesspositiveregulationofproteinkinaseBsignaling
Cell surface glycoprotein CD200 receptor 4
2.0
85
79
MO2R4MO2R4Q6XJV4Q6XJV4regulationofneuroinflammatoryresponse
Minor allergen Can f 2
2.0
nan
92
ALL2ALL2O18874O18874
Beta-defensin 12
2.0
57
85
DFB12DFB12P46170P46170cellchemotaxisdefenseresponsetobacterium
Cathelicidin-4
2.0
19
nan
CTHL4CTHL4P33046P33046antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetofungusdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponsekillingofcellsofanotherorganism
Major allergen I polypeptide chain 1
2.0
nan
88
FEL1AFEL1AP30438P30438
Beta-defensin 7
2.0
50
87
DEFB7DEFB7Q91V70Q91V70cellchemotaxisdefenseresponsetobacterium
Beta-defensin 8
2.0
54
86
DEFB8DEFB8Q91V82Q91V82cellchemotaxisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Protegrin-5
2.0
26
88
PG5PG5P49934P49934antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Aphrodisin
2.0
44
87
APHRAPHRP09465P09465
Protegrin-2
2.0
22
89
PG2PG2P32195P32195antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Chitinase-like protein 3
2.0
86
79
CHIL3CHIL3O35744O35744chitincatabolicprocessinflammatoryresponsepolysaccharidecatabolicprocesspositiveregulationofchemokineproductionproductionofmolecularmediatorinvolvedininflammatoryresponse
Protegrin-3
2.0
35
87
PG3PG3P32196P32196antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
RT1 class I histocompatibility antigen, AA alpha chain
2.0
83
81
HA12HA12P16391P16391antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofpeptideantigenviaMHCclassIimmuneresponse
Kallikrein 1-related peptidase b3
2.0
90
79
K1KB3K1KB3P00756P00756regulationofsystemicarterialbloodpressurezymogenactivation
T-cell immunoglobulin and mucin domain-containing protein 2
2.0
90
76
TIMD2TIMD2Q8R183Q8R183ironiontransportphagocytosisengulfmentpositiveregulationofmastcellactivation
Angiogenin-4
2.0
86
82
ANG4ANG4Q80Z85Q80Z85activationofphospholipaseA2activityactivationofphospholipaseCactivityactivationofproteinkinaseBactivityangiogenesisantibacterialhumoralresponseantifungalhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellmigrationcellularresponsetolipopolysaccharidedefenseresponsetobacteriumdefenseresponsetoGram-positivebacteriumdiacylglycerolbiosyntheticprocessinnateimmuneresponsenegativeregulationofsmoothmusclecellproliferationpositiveregulationofcellpopulationproliferationpositiveregulationofendothelialcellproliferationpositiveregulationofphosphorylationpositiveregulationofproteinsecretionresponsetobacteriumresponsetohormoneresponsetohypoxiaresponsetoyeastRNAcatabolicprocessrRNAtranscription
Protegrin-1
2.0
27
87
PG1PG1P32194P32194antimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponse
Solute carrier organic anion transporter family member 6C1
2.0
68
82
SO6C1SO6C1Q3V161Q3V161organicaniontransportsodium-independentorganicaniontransport
T-cell receptor beta-1 chain C region
2.0
89
81
TCB1TCB1P01852P01852BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
H-2 class I histocompatibility antigen, K-D alpha chain
2.0
82
79
HA1DHA1DP01902P01902antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-dependentantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIdefenseresponsetobacteriuminnereardevelopmentnegativeregulationofneuronprojectiondevelopmentpositiveregulationofTcellmediatedcytotoxicityTcellmediatedcytotoxicity
Kallikrein 1-related peptidase-like b4
2.0
65
84
K1KB4K1KB4P00757P00757positiveregulationofphosphatidylinositol3-kinaseactivityregulationofsystemicarterialbloodpressuresmallGTPasemediatedsignaltransductionzymogenactivation
Seminal plasma protein PDC-109
2.0
nan
89
SFP1SFP1P02784P02784phospholipideffluxpositiveregulationofspermcapacitationsinglefertilizationspermcapacitation
Conglutinin
2.0
69
83
CONGCONGP23805P23805extracellularmatrixorganization
Ig kappa chain V-III region PC 7043
2.0
94
79
KV3ADKV3ADP01665P01665adaptiveimmuneresponseimmuneresponse
Ig heavy chain V region 36-65
2.0
83
80
HVM03HVM03P01747P01747BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Duodenase-1
2.0
65
84
DDN1DDN1P80219P80219proteolysis
Immunoglobulin kappa chain variable 12-41
2.0
89
nan
KV5A3KV5A3P01635P01635adaptiveimmuneresponseimmuneresponse
Ig gamma-1 chain C region, membrane-bound form
3.7
nan
88
IGKCIGH1MP01837P01869BcelldifferentiationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationantibacterialhumoralresponseantibody-dependentcellularcytotoxicityhumoralimmuneresponsemediatedbycirculatingimmunoglobulinimmunoglobulinmediatedimmuneresponsepositiveregulationofimmuneresponsepositiveregulationofphagocytosispositiveregulationoftypeIhypersensitivitypositiveregulationoftypeIIahypersensitivity
Defensin alpha 4
2.0
46
87
DEFA4DEFA4P28311P28311antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriumdisruptionofmembraneintegrityinanotherorganisminnateimmuneresponseinmucosakillingofcellsofanotherorganism
Ig heavy chain V region 914
2.0
83
79
HVM56HVM56P18527P18527BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Seminal ribonuclease
2.0
55
87
RNSRNSP00669P00669defenseresponsetoGram-positivebacteriumRNAphosphodiesterbondhydrolysis
Major allergen Can f 1
2.0
48
87
ALL1ALL1O18873O18873
Ig gamma-2A chain C region
2.0
80
80
IGG2AIGG2AP20760P20760BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
H-2 class II histocompatibility antigen, A-K beta chain
2.0
80
80
HB2KHB2KP06343P06343adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigenimmuneresponsepeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
Major urinary protein
2.0
46
86
MUPMUPP02761P02761aerobicrespirationcellularresponsetolipidenergyreservemetabolicprocessglucosehomeostasisheatgenerationlocomotorrhythmmitochondrionmorphogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgluconeogenesisnegativeregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusnegativeregulationoflipidbiosyntheticprocessnegativeregulationoflipidstoragepositiveregulationofgeneexpressionpositiveregulationofglucosemetabolicprocesspositiveregulationoflipidmetabolicprocesspositiveregulationofproteinkinaseBsignaling
Ig heavy chain V region 1B43
2.0
83
80
HVM61HVM61P18532P18532BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
T-cell surface glycoprotein YE1/48
2.0
88
81
KLRA1KLRA1P20937P20937celladhesion
Ig heavy chain Mem5
2.0
nan
90
IGKCHVM63P01837P84751BcelldifferentiationBcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivationadaptiveimmuneresponse
RLA class I histocompatibility antigen, alpha chain 19-1
2.0
82
80
HA1BHA1BP06140P06140antigenprocessingandpresentationofpeptideantigenviaMHCclassIimmuneresponse
Renin-1
2.0
57
85
RENI1RENI1P06281P06281amyloid-betametabolicprocessangiotensinmaturationcellmaturationcellularresponsetoxenobioticstimulusdrinkingbehaviorhormone-mediatedsignalingpathwaykidneydevelopmentmalegonaddevelopmentmesonephrosdevelopmentproteolysisregulationofbloodpressureregulationofbloodvolumebyrenin-angiotensinregulationofMAPKcascaderenin-angiotensinregulationofaldosteroneproductionresponsetocAMPresponsetocGMPresponsetoimmobilizationstressresponsetolipopolysaccharideresponsetoorganicsubstanceresponsetoxenobioticstimulus
MHC class I-like protein MILL2
2.0
nan
89
MILL2MILL2Q8HWE5Q8HWE5cellularresponsetoDNAdamagestimulusdefenseresponsetobacteriumdefenseresponsetovirusgamma-deltaTcellactivationimmuneresponsetotumorcellnaturalkillercellmediatedcytotoxicitynegativeregulationofnaturalkillercellactivationnegativeregulationofnaturalkillercellmediatedcytotoxicityresponsetoheatTcellmediatedcytotoxicity
H-2 class II histocompatibility antigen, A-U alpha chain
2.0
81
79
HA2UHA2UP14438P14438adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigennegativeregulationofTcellproliferationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcelldifferentiation
T-cell ecto-ADP-ribosyltransferase 2
2.0
53
81
NAR2BNAR2BP20974P20974NADcatabolicprocess
Ig heavy chain V region 1-72
2.0
82
nan
HVM49HVM49P06328P06328BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Ig kappa chain V-V region HP 123E6
2.0
92
80
KV5ADKV5ADP01646P01646adaptiveimmuneresponseimmuneresponse
H-2 class I histocompatibility antigen, Q7 alpha chain
2.0
82
80
HA17HA17P14429P14429antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofpeptideantigenviaMHCclassIcellularresponsetotypeIIinterferonembryoimplantation
Retinoic acid early-inducible protein 1-gamma
2.0
74
82
RAE1CRAE1CO08604O08604cellularresponsetoexogenousdsRNAcellularresponsetolipopolysaccharidedefenseresponsetobacterium
Ig heavy chain V-III region J606
2.0
84
82
HVM32HVM32P01801P01801BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Renin-2
2.0
49
86
RENI2RENI2P00796P00796angiotensinmaturationgeneexpressionkidneydevelopmentpositiveregulationofbloodpressureproteolysisregulationofbloodpressureregulationofMAPKcascaderesponsetocAMPresponsetocGMPresponsetoxenobioticstimulus
H-2 class II histocompatibility antigen, A-U beta chain
2.0
81
79
HB2UHB2UP06344P06344adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
Retinoic acid early-inducible protein 1-beta
2.0
71
82
RAE1BRAE1BO08603O08603cellularresponsetoexogenousdsRNAcellularresponsetolipopolysaccharidedefenseresponsetobacteriumpositiveregulationofimmuneresponsetotumorcellpositiveregulationofmacrophageactivationpositiveregulationofnaturalkillercellactivationpositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationoftypeIIinterferonproductionsusceptibilitytonaturalkillercellmediatedcytotoxicity
Baculoviral IAP repeat-containing protein 1e
2.0
56
82
BIR1EBIR1EQ9R016Q9R016defenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdetectionofbacteriumentryofbacteriumintohostcellinflammatoryresponseinnateimmuneresponsenegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationoftumornecrosisfactor-mediatedsignalingpathwaypositiveregulationofinterleukin-1betaproductionpositiveregulationofJNKcascadepyroptosisregulationofapoptoticprocess
H-2 class II histocompatibility antigen, E-K alpha chain
2.0
80
80
HA22HA22P04224P04224adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivation
Major urinary protein 2
2.0
nan
92
MUP2MUP2P11589P11589aerobicrespirationcellularresponsetolipidenergyreservemetabolicprocessglucosehomeostasisheatgenerationlocomotorrhythmmitochondrionmorphogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgluconeogenesisnegativeregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusnegativeregulationoflipidbiosyntheticprocessnegativeregulationoflipidstoragepositiveregulationofgeneexpressionpositiveregulationofglucosemetabolicprocesspositiveregulationoflipidmetabolicprocesspositiveregulationofproteinkinaseBsignaling
Ig kappa chain V-V region L7
2.0
86
81
KV5A9KV5A9P01642P01642adaptiveimmuneresponseimmuneresponse
Ig heavy chain V region J558
2.0
88
nan
HVM13HVM13P01757P01757BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Antigen-presenting glycoprotein CD1d1
2.0
89
79
CD1D1CD1D1P11609P11609antigenprocessingandpresentationantigenprocessingandpresentationendogenouslipidantigenviaMHCclassIbantigenprocessingandpresentationexogenouslipidantigenviaMHCclassIbinnateimmuneresponseNKTcelldifferentiationpositiveregulationofinterleukin-2productionpositiveregulationofinterleukin-4productionpositiveregulationofmacrophageactivationpositiveregulationofNKTcellactivationpositiveregulationofNKTcelldifferentiationpositiveregulationofTcellmediatedcytotoxicitypositiveregulationofTcellproliferationpositiveregulationoftypeIIinterferonproductionpositivethymicTcellselectionregulationofimmatureTcellproliferationinthymusregulationofimmuneresponse
Odorant-binding protein
2.0
55
86
OBPOBPP81245P81245responsetostimulussensoryperceptionofsmell
Ig heavy chain V region 5-84
2.0
82
80
HVM54HVM54P18525P18525BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Selection and upkeep of intraepithelial T-cells protein 1
2.0
82
81
SKIT1SKIT1A7TZE6A7TZE6epithelialcelldifferentiationgamma-deltaTcelldifferentiationpositiveregulationofepithelialcelldifferentiationpositiveregulationofgamma-deltaTcelldifferentiationpositiveregulationofTcelldifferentiationpositiveregulationofTcelldifferentiationinthymuspositivethymicTcellselectionregulationofcytokineproductionTcelldifferentiationTcellreceptorsignalingpathway
H-2 class II histocompatibility antigen, A-K alpha chain
2.0
82
79
HA2KHA2KP01910P01910adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigennegativeregulationofTcellproliferationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcelldifferentiation
Granzyme C
2.0
91
80
GRACGRACP08882P08882cytolysisproteolysis
Short palate, lung and nasal epithelium carcinoma-associated protein 2B
2.0
44
85
SPL2BSPL2BP79125P79125
Killer cell lectin-like receptor subfamily B member 1B allele B
2.0
nan
89
KRBBBKRBBBQ99JB4Q99JB4negativeregulationofnaturalkillercellmediatedcytotoxicityregulationofnaturalkillercellmediatedcytotoxicity
H-2 class II histocompatibility antigen, I-A beta chain
2.0
78
80
HB2IHB2IP18468P18468adaptiveimmuneresponseantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationresponsetotypeIIinterferon
Ig kappa chain V-II region 26-10
2.0
87
80
KV2A7KV2A7P01631P01631adaptiveimmuneresponseimmuneresponse
Intestinal-type alkaline phosphatase 1
2.0
60
87
PPBI1PPBI1P15693P15693cellularresponsetoBMPstimulusdephosphorylationphosphorusmetabolicprocess
Major allergen I polypeptide chain 2
2.0
58
82
FEL1BFEL1BP30440P30440
H-2 class I histocompatibility antigen, D-37 alpha chain
2.0
80
81
HA15HA15P06339P06339antigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIbviaERpathwayTAP-dependentantigenprocessingandpresentationofpeptideantigenviaMHCclassIinnereardevelopmentpositiveregulationofTcellmediatedcytotoxicityTcellmediatedcytotoxicity
Spermadhesin-1
2.0
56
84
SPAD1SPAD1P29392P29392singlefertilization
Major urinary protein 1
2.0
nan
91
MUP1MUP1P11588P11588aerobicrespirationcellularresponsetofoodcellularresponsetolipidcellularresponsetostarvationcellularresponsetotestosteronestimulusenergyreservemetabolicprocessglucosehomeostasisheatgenerationlocomotorrhythmmitochondrionmorphogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgluconeogenesisnegativeregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusnegativeregulationoflipidbiosyntheticprocessnegativeregulationoflipidstoragepositiveregulationofgeneexpressionpositiveregulationofglucosemetabolicprocesspositiveregulationoflipidmetabolicprocesspositiveregulationofproteinkinaseBsignalingresponsetostilbenoid
MLV-related proviral Env polyprotein
2.1
68
81
ENV1ENV1P10404P10404
C-type lectin domain family 2 member D11
2.1
78
81
CL2DBCL2DBQ0H8B9Q0H8B9
Ig kappa chain V-V region MOPC 149
2.1
86
79
KV5A4KV5A4P01636P01636adaptiveimmuneresponseimmuneresponse
Beta-lactoglobulin-1
2.1
94
78
LACB1LACB1P02758P02758
Lipocalin Can f 6.0101
2.1
47
86
LI601LI601H2B3G5H2B3G5
C-type lectin domain family 2 member I
2.1
75
82
CLC2ICLC2IQ9WVF9Q9WVF9membraneraftassemblynegativeregulationofosteoclastdifferentiationpositiveregulationofimmunologicalsynapseformationreceptorclusteringregulationofactinfilamentpolymerizationregulationofinterleukin-2productionregulationofTcellproliferationTcellreceptorsignalingpathway
Interferon tau-1
2.1
nan
90
IFNT1IFNT1P56828P56828defenseresponsetovirusfemalepregnancy
Ig kappa chain V-III region PC 3741/TEPC 111
2.1
96
78
KV3A8KV3A8P01660P01660adaptiveimmuneresponseimmuneresponse
Ig lambda-2 chain C region
2.1
89
77
LAC2LAC2P01844P01844BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Major urinary protein 4
2.2
49
85
MUP4MUP4P11590P11590aerobicrespirationcellularresponsetolipidenergyreservemetabolicprocessglucosehomeostasisheatgenerationlocomotorrhythmmitochondrionmorphogenesisnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgluconeogenesisnegativeregulationofinsulinsecretioninvolvedincellularresponsetoglucosestimulusnegativeregulationoflipidbiosyntheticprocessnegativeregulationoflipidstoragepositiveregulationofgeneexpressionpositiveregulationofglucosemetabolicprocesspositiveregulationoflipidmetabolicprocesspositiveregulationofproteinkinaseBsignaling
Ig heavy chain V region 36-60
2.2
83
80
HVM47HVM47P01823P01823BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Ig heavy chain V region 5-76
2.3
86
77
HVM58HVM58P18529P18529BcellreceptorsignalingpathwaycomplementactivationclassicalpathwaydefenseresponsetobacteriuminnateimmuneresponsephagocytosisengulfmentphagocytosisrecognitionpositiveregulationofBcellactivation
Alcohol dehydrogenase E chain
2.7
68
86
ADH1EADH1EP00327P00327ethanoloxidationretinoicacidmetabolicprocessretinolmetabolicprocess
E3 ubiquitin-protein ligase SIAH1A
3.0
55
85
SIA1ASIA1AP61092P61092canonicalWntsignalingpathwaycelldifferentiationmalemeiosisIneuronapoptoticprocesspositiveregulationofapoptoticprocesspositiveregulationofintrinsicapoptoticsignalingpathwaypost-embryonicdevelopmentproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteincatabolicprocessproteindestabilizationregulationofmulticellularorganismgrowthspermatogenesisubiquitin-dependentproteincatabolicprocess
Defensin alpha-like protein 1
3.0
72
78
DFAL1DFAL1Q4JEI2Q4JEI2antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosa
Metallothionein-2A
3.2
51
99
MT2AMT2AP18055P18055cellularresponsetozincionnegativeregulationofgrowth
Integrin beta-2-like protein
3.4
59
75
ITB2LITB2LQ3UV74Q3UV74celladhesioncelladhesionmediatedbyintegrincellmigrationcell-celladhesioncell-matrixadhesioncellularextravasationendothelialcellmigrationheterotypiccell-celladhesionintegrin-mediatedsignalingpathwayleukocytecell-celladhesionleukocytemigrationinvolvedininflammatoryresponsenaturalkillercellactivationneutrophilchemotaxisneutrophilmigrationpositiveregulationofangiogenesispositiveregulationofneutrophildegranulationpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidebiosyntheticprocesspositiveregulationofsuperoxideaniongenerationreceptorclusteringregulationofpeptidyl-tyrosinephosphorylation
MYND-type zinc finger-containing chromatin reader ZMYND8
3.5
60
78
ZMYD8ZMYD8Q9ULU4Q9ULU4double-strandbreakrepairviahomologousrecombinationnegativeregulationofcellmigrationnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinlocalizationtochromatin
Tripartite motif-containing protein 30A
3.6
51
78
TR30ATR30AP15533P15533activationofinnateimmuneresponseautophagyinnateimmuneresponsenegativeregulationofinterleukin-6productionnegativeregulationofNLRP3inflammasomecomplexassemblynegativeregulationofreactiveoxygenspeciesmetabolicprocessnegativeregulationoftoll-likereceptorsignalingpathwaynegativeregulationoftumornecrosisfactorproductionnegativeregulationofviralentryintohostcellpositiveregulationofautophagypositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofMAPKcascadepositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofproteincatabolicprocesspositiveregulationofviralentryintohostcellproteinautoubiquitinationproteinK63-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofgeneexpressionregulationoflipopolysaccharide-mediatedsignalingpathwayregulationofproteinlocalizationregulationofviralentryintohostcellresponsetobacteriumsuppressionofviralreleasebyhost
Metallothionein-1
3.6
nan
90
MT1MT1P02802P02802cellularmetalionhomeostasiscellularresponsetocadmiumioncellularresponsetochromatecellularresponsetocopperioncellularresponsetozincioncellularzincionhomeostasisdetoxificationofcopperionnegativeregulationofgrowthnegativeregulationofneuronapoptoticprocessnitricoxidemediatedsignaltransduction
Gamma-crystallin F
3.6
69
81
CRGFCRGFP23005P23005lensdevelopmentincamera-typeeyevisualperception
Alcohol dehydrogenase S chain
3.6
98
69
ADH1SADH1SP00328P00328ethanoloxidationretinoicacidmetabolicprocessretinolmetabolicprocess
Gamma-crystallin E
3.9
66
79
CRGECRGEP02528P02528lensdevelopmentincamera-typeeyevisualperception
Interferon-activable protein 202
4.0
77
72
IFI2IFI2Q9R002Q9R002activationofinnateimmuneresponsecellularresponsetointerferon-betainflammatoryresponseinnateimmuneresponsenegativeregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessnegativeregulationofinnateimmuneresponsepositiveregulationofinterleukin-1betaproductionresponsetobacterium
Aldehyde dehydrogenase, cytosolic 1
4.4
98
58
ALDH1ALDH1Q28399Q28399ethanolcatabolicprocessretinalmetabolicprocess
Cytochrome P450 2C5
4.7
82
63
CP2C5CP2C5P00179P00179
Nucleoside diphosphate kinase A 1
5.1
56
59
NDKA1NDKA1P52174P52174celldifferentiationCTPbiosyntheticprocessendocytosisGTPbiosyntheticprocessnervoussystemdevelopmentnucleosidediphosphatephosphorylationUTPbiosyntheticprocess
Acyl-CoA desaturase 1
5.1
59
69
ACOD1ACOD1P13516P13516brownfatcelldifferentiationcholesterolhomeostasisdefenseresponsetoGram-positivebacteriumfattyacidbiosyntheticprocesslipidbiosyntheticprocesslipidhomeostasismonounsaturatedfattyacidbiosyntheticprocesspositiveregulationofcold-inducedthermogenesisresponsetobacteriumresponsetofattyacidsebaceousglanddevelopmentsterolhomeostasistarsalglanddevelopmenttriglyceridemetabolicprocessunsaturatedfattyacidbiosyntheticprocesswhitefatcelldifferentiation
Toll-like receptor 13
5.6
77
48
TLR13TLR13Q6R5N8Q6R5N8inflammatoryresponseinnateimmuneresponseMyD88-dependenttoll-likereceptorsignalingpathwayregulationofMAPKcascaderesponsetovirustoll-likereceptor13signalingpathwaytoll-likereceptorsignalingpathway
Interferon-inducible GTPase 1
5.6
46
66
IIGP1IIGP1Q9QZ85Q9QZ85cellularresponsetointerferon-betacytokine-mediatedsignalingpathwaydefenseresponsedefenseresponsetoGram-negativebacteriumdefenseresponsetoprotozoaninnateimmuneresponseregulationofautophagyresponsetobacterium
Beta-defensin 4
7.4
19
62
DEFB4DEFB4P82019P82019cellchemotaxischemotaxisdefenseresponsetobacteriumdefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacterium
NACHT, LRR and PYD domains-containing protein 1 allele 2
7.8
67
43
NL1A2NL1A2D9I2G3D9I2G3activationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessantiviralinnateimmuneresponsecellularresponsetoUV-BdefenseresponsetobacteriumdefenseresponsetovirusinflammatoryresponsenegativeregulationofcellulardefenseresponseneuronapoptoticprocessNLRP1inflammasomecomplexassemblypositiveregulationofinflammatoryresponsepositiveregulationofinterleukin-1betaproductionpositiveregulationofpyroptosisprogrammednecroticcelldeathproteinhomooligomerizationpyroptosisregulationofapoptoticprocessresponsetomuramyldipeptideselfproteolysisstress-activatedproteinkinasesignalingcascade
Tubulin alpha-1D chain
8.1
94
34
TBA1DTBA1DQ2HJ86Q2HJ86microtubulecytoskeletonorganizationmitoticcellcycle
Alpha-defensin 14
8.1
68
47
DFA14DFA14P50712P50712antibacterialhumoralresponseantimicrobialhumoralimmuneresponsemediatedbyantimicrobialpeptidecellularresponsetolipopolysaccharidedefenseresponsetoGram-negativebacteriumdefenseresponsetoGram-positivebacteriuminnateimmuneresponseinmucosa
Galectin-5
8.2
69
34
LEG5LEG5P47967P47967negativeregulationofCD4-positivealpha-betaTcellproliferationnegativeregulationoftypeIIinterferonproductionpositiveregulationofgeneexpressionpositiveregulationofTcellapoptoticprocess
Cytochrome c, testis-specific
8.8
54
44
CYC2CYC2P00015P00015apoptoticprocesshydrogenperoxidemetabolicprocessmitochondrialelectrontransportcytochromectooxygenmitochondrialelectrontransportubiquinoltocytochromecpositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofintrinsicapoptoticsignalingpathway
3-alpha-hydroxysteroid dehydrogenase
8.9
76
34
DIDHDIDHP23457P23457daunorubicinmetabolicprocessdoxorubicinmetabolicprocesshippocampusdevelopmentprogesteronemetabolicprocessprostaglandinmetabolicprocesssteroidmetabolicprocess
Aldo-keto reductase family 1 member C13
9.2
87
33
AK1CDAK1CDQ8VC28Q8VC28steroidmetabolicprocessxenobioticmetabolicprocess
Interferon-activable protein 204
9.8
70
34
IFI4IFI4P0DOV2P0DOV2activationofcysteine-typeendopeptidaseactivityactivationofinnateimmuneresponsecellularresponsetoglucosestarvationcellularresponsetointerferon-alphacellularresponsetointerferon-betacellularresponsetoionizingradiationdefenseresponsetovirusepigeneticregulationofgeneexpressioninnateimmuneresponseinnereardevelopmentintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatormonocytedifferentiationnegativeregulationofcysteine-typeendopeptidaseactivitynegativeregulationofDNAbindingnegativeregulationofDNA-templatedtranscriptionnegativeregulationofinnateimmuneresponsenegativeregulationoftranscriptionbyRNApolymeraseIInegativeregulationofviralgenomereplicationpositiveregulationofinterleukin-1betaproductionpositiveregulationofosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetobacterium
Complement C4-B
2.0
56
86
CO4ACO4BP0C0L4P0C0L5complementactivationcomplementactivationclassicalpathwayinflammatoryresponseinnateimmuneresponsepositiveregulationofapoptoticcellclearancepositiveregulationofimmuneresponsepositiveregulationofopsonizationdetectionofmoleculeofbacterialoriginopsonization
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
2.0
79
81
NDUBANDUBBO96000Q9NX14aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesis
NADH-ubiquinone oxidoreductase chain 5
2.0
73
81
NDUB8X5BVZ3O95169X5BVZ3aerobicrespirationmitochondrialelectrontransportNADHtoubiquinonemitochondrialrespiratorychaincomplexIassemblyprotonmotiveforce-drivenmitochondrialATPsynthesisATPsynthesiscoupledelectrontransport
Sulfiredoxin-1
2.1
75
80
PRDX1SRXN1Q06830Q9BYN0cellpopulationproliferationcellredoxhomeostasiscellularresponsetochemicalstresserythrocytehomeostasisfibroblastproliferationhydrogenperoxidecatabolicprocessleukocyteactivationnaturalkillercellactivationnaturalkillercellmediatedcytotoxicityregulationofNIK/NF-kappaBsignalingregulationofstress-activatedMAPKcascaderemovalofsuperoxideradicalsretinahomeostasisskeletalsystemdevelopmentcellularresponsetooxidativestressresponsetooxidativestress
DNA replication licensing factor MCM5
3.5
70
85
MCM3MCM5P25205P33992DNAreplicationinitiationDNAstrandelongationinvolvedinDNAreplicationDNAunwindinginvolvedinDNAreplicationdouble-strandbreakrepairviabreak-inducedreplicationmitoticDNAreplicationinitiationregulationofDNA-templatedDNAreplicationinitiationcellcycleDNAreplication
FMR1-interacting protein NUFIP1
3.6
84
72
ZNHI3NUFP1Q15649Q9UHK0boxC/DsnoRNPassemblymaturationofLSU-rRNAfromtricistronicrRNAtranscript(SSU-rRNA5.8SrRNALSU-rRNA)regulationofDNA-templatedtranscriptionsnoRNAlocalizationpositiveregulationoftranscriptionbyRNApolymeraseIIRNAprocessing
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
3.7
75
72
A0A6P3EI17A0A836CQA7A0A6P3EI17A0A836CQA7
Phorbol-12-myristate-13-acetate-induced protein 1
3.9
60
72
B2LA1APRQ16548Q13794extrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagenegativeregulationofapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessapoptoticprocesscellularresponsetoDNAdamagestimuluscellularresponsetoglucosestarvationcellularresponsetohypoxiadefenseresponsetovirusintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatornegativeregulationofmitochondrialmembranepotentialpositiveregulationofapoptoticprocesspositiveregulationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocesspositiveregulationofDNAdamageresponsesignaltransductionbyp53classmediatorpositiveregulationofendoplasmicreticulumstress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofextrinsicapoptoticsignalingpathwayviadeathdomainreceptorspositiveregulationofglucosemetabolicprocesspositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofreleaseofcytochromecfrommitochondriaproteasomalproteincatabolicprocessreactiveoxygenspeciesmetabolicprocessregulationofmitochondrialmembranepermeabilityreleaseofcytochromecfrommitochondriaresponsetodsRNATcellhomeostasis
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
3.9
75
71
A0A4X1VYV0A0A287BMW6A0A4X1VYV0A0A287BMW6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
4.0
77
70
A0A4X1VYV0A0A8D1EYI7A0A4X1VYV0A0A8D1EYI7
Transcription and mRNA export factor ENY2
4.0
77
77
GANPENY2O60318Q9NPA8mRNAexportfromnucleusnucleosomeorganizationpoly(A)+mRNAexportfromnucleusproteintransportsomatichypermutationofimmunoglobulingeneschromatinorganizationhistonedeubiquitinationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoter
Protein lin-37 homolog
4.1
86
66
LIN9LIN37Q5TKA1Q96GY3cellcycleDNAbiosyntheticprocessDNA-templatedtranscriptionregulationofcellcycleregulationoftranscriptionbyRNApolymeraseIIreproductionnegativeregulationoftranscriptionbyRNApolymeraseII
Transcriptional adapter 1
4.2
77
72
TRRAPTADA1Q9Y4A5Q96BN2chromatinorganizationDNArepairhistoneacetylationhistoneH2AacetylationhistoneH3acetylationhistoneH4acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofapoptoticprocessregulationofcellcycleregulationofDNArepairregulationofDNA-templatedtranscriptionregulationofdouble-strandbreakrepairregulationofRNAsplicingregulationoftranscriptionbyRNApolymeraseII
Mitochondrial import inner membrane translocase subunit Tim29
4.3
69
77
AGKTIM29Q53H12Q9BSF4ceramidebiosyntheticprocessglycerolipidmetabolicprocessphosphorylationproteininsertionintomitochondrialinnermembranesphingolipidmetabolicprocess
Guanine nucleotide-binding protein G(o) subunit alpha
4.7
72
72
ACM2GNAOP08172P09471adenylatecyclase-inhibitingGprotein-coupledacetylcholinereceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwayGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengernervoussystemdevelopmentphospholipaseC-activatingGprotein-coupledacetylcholinereceptorsignalingpathwaypresynapticmodulationofchemicalsynaptictransmissionregulationofheartcontractionregulationofsmoothmusclecontractionresponsetovirusdopaminereceptorsignalingpathwaymusclecontraction
Ubiquitin-conjugating enzyme E2 L3
4.5
63
71
✔
ARI1UB2L3Q9Y4X5P68036positiveregulationofproteasomalubiquitin-dependentproteincatabolicprocessproteinpolyubiquitinationproteinubiquitinationubiquitin-dependentproteincatabolicprocesscellcyclephasetransitioncellpopulationproliferationcellularresponsetoglucocorticoidstimuluscellularresponsetosteroidhormonestimuluspositiveregulationofproteintargetingtomitochondrionpositiveregulationofproteinubiquitinationpositiveregulationofubiquitin-proteintransferaseactivityproteinK11-linkedubiquitinationproteinmodificationprocessregulationofDNA-templatedtranscription
Nonsense-mediated mRNA decay factor SMG9
4.5
68
70
✔
SMG1SMG9Q96Q15Q9H0W8DNArepairmRNAexportfromnucleusnegativeregulationofmacroautophagynuclear-transcribedmRNAcatabolicprocessnonsense-mediateddecaypeptidyl-serinephosphorylationphosphatidylinositolphosphatebiosyntheticprocessproteinautophosphorylationproteinphosphorylationregulationofresponsetoDNAdamagestimulusregulationoftelomeremaintenanceTORsignalingbraindevelopmenteyedevelopmentheartdevelopmentinuteroembryonicdevelopment
Transcription factor JunD
4.8
45
73
FOSBJUNDP53539P17535cellularresponsetocalciumioncellularresponsetohormonestimulusfemalepregnancynegativeregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIresponsetocAMPresponsetocorticosteroneresponsetomechanicalstimulusresponsetomorphineresponsetoprogesteroneresponsetoxenobioticstimulustranscriptionbyRNApolymeraseIIagingcellularresponsetohypoxiacircadianrhythmosteoblastdevelopmentpositiveregulationofmacrophageactivationpositiveregulationofosteoblastdifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIregulationofcellcycleregulationofcellpopulationproliferationregulationofDNA-bindingtranscriptionfactoractivityresponsetolightstimulusresponsetolipopolysaccharideresponsetoorganiccycliccompoundresponsetopeptidehormone
Dynactin subunit 5
5.3
78
56
DCTN6DCTN5D0G6S1A0A286ZK88mitoticspindleorganizationaortadevelopmentcoronaryvasculaturedevelopmentventricularseptumdevelopment
Kinetochore-associated protein NSL1 homolog
5.3
70
59
DSN1NSL1Q9H410Q96IY1celldivisionmitoticsisterchromatidsegregation
DNA-directed RNA polymerases I and III subunit RPAC2
5.5
71
54
RPAC1RPAC2O15160P0DPB6transcriptionbyRNApolymeraseIDNA-templatedtranscription
Cell cycle checkpoint protein RAD17
5.6
74
61
RFC3RAD17P40938O75943DNAduplexunwindingDNArepairDNAreplicationDNAstrandelongationinvolvedinDNAreplicationDNAsynthesisinvolvedinDNArepairDNA-templatedDNAreplicationpositiveregulationofDNA-directedDNApolymeraseactivityresponsetoorganophosphoruscellularresponsetoDNAdamagestimulusDNAdamagecheckpointsignalingDNAreplicationcheckpointsignalingmitoticDNAreplicationcheckpointsignalingmitoticintra-SDNAdamagecheckpointsignalingnegativeregulationofDNAreplicationregulationofphosphorylation
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
6.1
85
46
STT3ADAD1P46977P61803co-translationalproteinmodificationpost-translationalproteinmodificationproteinN-linkedglycosylationproteinN-linkedglycosylationviaasparagineapoptoticprocessblastocystdevelopmentnegativeregulationofapoptoticprocessproteinglycosylationregulationofproteinstabilityresponsetonutrientresponsetoxenobioticstimulus
Small nuclear ribonucleoprotein F
7.0
75
49
SMD2RUXFP62317P62321mRNAsplicingviaspliceosomespliceosomalsnRNPassembly
HAUS augmin-like complex subunit 4
7.0
74
48
HAUS3HAUS4Q68CZ6Q9H6D7celldivisioncentrosomecyclespindleassembly
THO complex subunit 7 homolog
7.5
69
47
✔
THOC5THOC7Q13769Q6I9Y2monocytedifferentiationmRNAexportfromnucleusmRNAprocessingnegativeregulationofDNAdamagecheckpointpositiveregulationofDNA-templatedtranscriptionelongationprimitivehemopoiesisRNAsplicingviralmRNAexportfromhostcellnucleus
Rod outer segment membrane protein 1
7.7
81
47
PRPH2ROM1P23942Q03395celladhesiondetectionoflightstimulusinvolvedinvisualperceptionphotoreceptorcelloutersegmentorganizationproteinheterooligomerizationproteinhomooligomerizationresponsetolowlightintensitystimulusretinadevelopmentincamera-typeeyevisualperceptioncamera-typeeyephotoreceptorcelldifferentiationproteinlocalizationtophotoreceptoroutersegmentregulationofgeneexpressionretinavasculaturedevelopmentincamera-typeeye
Mediator of RNA polymerase II transcription subunit 22
7.6
61
49
✔
MED11MED22Q9P086Q15528positiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassembly
Guanine nucleotide-binding protein G(i) subunit alpha-2
7.7
74
45
FPR2GNAI2P25090P04899adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayastrocyteactivationcalcium-mediatedsignalingcelladhesioncellsurfacereceptorsignalingpathwaycellularresponsetoamyloid-betachemotaxiscomplementreceptormediatedsignalingpathwaydefenseresponsetobacteriumGprotein-coupledreceptorsignalingpathwayimmuneresponse-regulatingcellsurfacereceptorsignalingpathwayinflammatoryresponsemicroglialcellactivationnegativeregulationofinflammatoryresponsephospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypositivechemotaxispositiveregulationof1-phosphatidylinositol-3-kinaseactivitypositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofERK1andERK2cascadepositiveregulationofinnateimmuneresponsepositiveregulationofmonocytechemotaxispositiveregulationofphagocytosispositiveregulationofproteinphosphorylationpositiveregulationofsuperoxideaniongenerationreceptor-mediatedendocytosisadenylatecyclase-activatingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellpopulationproliferationGprotein-coupledacetylcholinereceptorsignalingpathwayGprotein-coupledadenosinereceptorsignalingpathwaygamma-aminobutyricacidsignalingpathwaynegativeregulationofadenylatecyclaseactivitynegativeregulationofadenylatecyclase-activatingadrenergicreceptorsignalingpathwayinvolvedinheartprocessnegativeregulationofapoptoticsignalingpathwaynegativeregulationofcalciumion-dependentexocytosisnegativeregulationofproteintyrosinephosphataseactivitynegativeregulationofsynaptictransmissionpositiveregulationofcellmigrationpositiveregulationofcellpopulationproliferationpositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofNAD(P)Hoxidaseactivitypositiveregulationofneuralprecursorcellproliferationpositiveregulationofrenalsodiumexcretionpositiveregulationofurinevolumepositiveregulationofvascularassociatedsmoothmusclecellproliferationregulationofcalciumiontransportresponsetonutrientsignaltransduction
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
7.8
92
40
A0A6P7E5N1A0A6P3TFB2A0A7M4DUG3A0A6P3TFB2
Protein Tob1
8.0
81
39
CNOT7TOB1Q9UIV1P50616deadenylation-dependentdecappingofnuclear-transcribedmRNAdefenseresponsetovirusexonucleolyticcatabolismofdeadenylatedmRNAmiRNA-mediatedgenesilencingnegativeregulationofcellpopulationproliferationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofgeneexpressionnegativeregulationoftypeIinterferon-mediatedsignalingpathwaynuclear-transcribedmRNApoly(A)tailshorteningP-bodyassemblypositiveregulationofcellpopulationproliferationpositiveregulationofmRNAcatabolicprocesspositiveregulationofnuclear-transcribedmRNAcatabolicprocessdeadenylation-dependentdecaypositiveregulationofnuclear-transcribedmRNApoly(A)tailshorteningpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofviralgenomereplicationregulationoftyrosinephosphorylationofSTATproteinRNA-mediatedgenesilencingnegativeregulationofBMPsignalingpathwaynegativeregulationofnuclear-transcribedmRNApoly(A)tailshorteningnegativeregulationofosteoblastdifferentiationnegativeregulationoftranslationregulationofgeneexpressionregulationofSMADproteinsignaltransduction
Integrator complex subunit 14
8.1
77
41
INT13INT14Q9NVM9Q96SY0celldivisioncentrosomelocalizationflagellatedspermmotilitymitoticspindleorganizationproteinlocalizationtonuclearenveloperegulationoffertilizationregulationofmitoticcellcycleregulationoftranscriptionelongationbyRNApolymeraseIIsnRNAprocessing"snRNA3-endprocessing"
Cytochrome c oxidase subunit 8A, mitochondrial
8.1
66
51
COX7CCOX8AP15954P10176cellularrespirationgenerationofprecursormetabolitesandenergymitochondrialelectrontransportcytochromectooxygen
Anti-coagulant protein 5
8.2
97
42
FA10Q16940P00742Q16940bloodcoagulationbloodcoagulationcommonpathwaypositiveregulationofcellmigrationpositiveregulationofproteinkinaseBsignalingproteolysiszymogenactivationnegativeregulationofpeptidaseactivity
ER membrane protein complex subunit 6
8.3
79
37
✔
EMC5EMC6Q8N4V1Q9BV81copperiontransportmagnesiumiontransportproteininsertionintoERmembranebystop-transfermembrane-anchorsequencetail-anchoredmembraneproteininsertionintoERmembraneautophagosomeassembly
Clathrin light chain B
8.4
70
48
✔
CLH1CLCBP49951P04975amyloid-betaclearancebytranscytosisautophagycelldivisionclathrincoatassemblyclathrin-dependentendocytosisintracellularproteintransportmitoticcellcyclenegativeregulationofhyaluronanbiosyntheticprocessnegativeregulationofproteinlocalizationtoplasmamembranereceptorinternalizationreceptor-mediatedendocytosisregulationofmitoticspindleorganizationretrogradetransportendosometoGolgitransferrintransport
Suppressor of cytokine signaling
8.5
nan
41
ELOCC0LEJ4Q15369C0LEJ4proteinubiquitinationregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocessintracellularsignaltransductionnegativeregulationofsignaltransduction
Guanine nucleotide-binding protein G(t) subunit alpha-2
8.5
65
41
RIC8AGNAT2Q5E9J8P19087adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaybasementmembraneorganizationcellmigrationinvolvedingastrulationcell-celladhesioninvolvedingastrulationGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentvasculaturedevelopmentvisuallearningadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaydetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertastedetectionoflightstimulusinvolvedinvisualperceptionphototransductionpositiveregulationofcytosoliccalciumionconcentrationresponsetolightintensityretinalconecelldevelopmentvisualperception
Non-homologous end joining factor IFFO1
8.6
37
49
XRCC4IFFO1Q13426Q0D2I5DNAligationinvolvedinDNArepairdouble-strandbreakrepairdouble-strandbreakrepairvianonhomologousendjoiningimmunoglobulinV(D)Jrecombinationpositiveregulationofligaseactivitypositiveregulationofphosphatidylserineexposureonapoptoticcellsurfaceproteinlocalizationtositeofdouble-strandbreakresponsetoX-rayDNAdouble-strandbreakattachmenttonuclearenvelope
Transcription initiation factor TFIID subunit 10
8.7
58
43
ST65GTAF10O94864Q12962histoneH3acetylationmaintenanceofproteinlocationinnucleusmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationpositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingallantoisdevelopmentapoptoticprocessDNA-templatedtranscriptioninitiationembryonicplacentadevelopmentG1/StransitionofmitoticcellcyclehepatocytedifferentiationhistoneacetylationlateralmesodermalcelldifferentiationlimbdevelopmentmRNAtranscriptionbyRNApolymeraseIImulticellularorganismgrowthpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinphosphorylationregulationofDNAbindingregulationofDNA-templatedtranscriptionregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblySAGAcomplexassemblysomitogenesistranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoter
Dipeptidyl-peptidase 6
8.7
57
44
KCND2A7E2E4Q9NZV8A7E2E4actionpotentialcellularresponsetohypoxiachemicalsynaptictransmissionlocomotorrhythmneuronalactionpotentialpotassiumiontransmembranetransportproteinhomooligomerizationregulationofiontransmembranetransportsensoryperceptionofpainproteolysis
Suppressor of cytokine signaling 2
8.8
nan
37
ELOCSOCS2Q15369O14508proteinubiquitinationregulationoftranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoterubiquitin-dependentproteincatabolicprocesscellularresponsetohormonestimulusgrowthhormonereceptorsignalingpathwayintracellularsignaltransductionlactationmammaryglandalveolusdevelopmentnegativeregulationofapoptoticprocessnegativeregulationofmulticellularorganismgrowthnegativeregulationofreceptorsignalingpathwayviaJAK-STATphosphatidylinositolphosphatebiosyntheticprocesspositiveregulationofneurondifferentiationreceptorsignalingpathwayviaJAK-STATregulationofcellgrowthregulationofsignaltransductionresponsetoestradiol
SNW domain-containing protein 1
8.8
64
35
✔
PRP8SNW1Q6P2Q9Q13573cellularresponsetolipopolysaccharidecellularresponsetotumornecrosisfactormRNAprocessingmRNAsplicingviaspliceosomeRNAsplicingRNAsplicingviatransesterificationreactionsspliceosomaltri-snRNPcomplexassemblycellularresponsetoretinoicacidintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationbyhostofviraltranscriptionpositiveregulationofhistoneH3-K4methylationpositiveregulationofmRNAsplicingviaspliceosomepositiveregulationofneurogenesispositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftransforminggrowthfactorbetareceptorsignalingpathwaypositiveregulationofvitaminDreceptorsignalingpathwayregulationofretinoicacidreceptorsignalingpathwayregulationoftranscriptionbyRNApolymeraseIIregulationofvitaminDreceptorsignalingpathwayretinoicacidreceptorsignalingpathway
Target of rapamycin complex 2 subunit MAPKAP1
8.9
79
35
RICTRSIN1Q6R327Q9BPZ7actincytoskeletonreorganizationcellularresponsetonutrientlevelscytoskeletonorganizationembryodevelopmentendinginbirthoregghatchingnegativeregulationofapoptoticprocesspeptidyl-serinephosphorylationphosphorylationpositiveregulationofactinfilamentpolymerizationpositiveregulationofcellgrowthpositiveregulationofpeptidyl-tyrosinephosphorylationpositiveregulationofproteinkinaseBsignalingpositiveregulationofTORsignalingregulationofactincytoskeletonorganizationregulationofestablishmentofcellpolarityregulationofgeneexpressionregulationofGTPaseactivityregulationofinflammatoryresponseregulationofpeptidyl-serinephosphorylationregulationofproteinkinaseBsignalingTORC2signalingnegativeregulationofRasproteinsignaltransductionpositiveregulationofpeptidyl-serinephosphorylationregulationofcellularresponsetooxidativestresssubstantianigradevelopment
DNA-directed RNA polymerase III subunit RPC4
8.9
80
32
RPC2RPC4Q9NW08P05423defenseresponsetovirusDNA-templatedtranscriptioninnateimmuneresponsepositiveregulationofinnateimmuneresponsepositiveregulationofinterferon-betaproductiontranscriptionbyRNApolymeraseIII
Prefoldin subunit 5
9.0
92
26
PFD3PFD5P61758Q99471microtubule-basedprocessnegativeregulationofamyloidfibrilformationproteinfoldingproteinstabilizationtubulincomplexassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofDNA-templatedtranscriptionregulationofDNA-templatedtranscriptionretinadevelopmentincamera-typeeye
Actin-related protein 2/3 complex subunit 4
9.0
91
32
ARC1BARPC4Q58CQ2Q148J6Arp2/3complex-mediatedactinnucleationactinfilamentpolymerization
Hemoglobin subunit delta
9.0
87
28
HBAHBDP69905P02042carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportpositiveregulationofcelldeathresponsetohydrogenperoxide
Purine NTPase
9.1
62
39
✔
VATAQ5ZWW6P38606Q5ZWW6cellularironionhomeostasiscellularresponsetoincreasedoxygenlevelsendosomallumenacidificationGolgilumenacidificationintracellularpHreductionlysosomallumenacidificationprotontransmembranetransportregulationofmacroautophagysynapticvesiclelumenacidificationvacuolaracidification
Hemoglobin subunit beta
9.3
87
27
HBAA0A481SHK9P69905A0A481SHK9carbondioxidetransportcellularoxidantdetoxificationhydrogenperoxidecatabolicprocessnitricoxidetransportoxygentransportpositiveregulationofcelldeathresponsetohydrogenperoxide
COP9 signalosome complex subunit 8
9.3
68
33
CSN3CSN8Q9UNS2Q99627inuteroembryonicdevelopmentproteindeneddylationproteinneddylationregulationofDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorregulationofproteinneddylationresponsetolightstimulussignaltransductionubiquitin-dependentproteincatabolicprocessactivationofNF-kappaB-inducingkinaseactivityCOP9signalosomeassemblynegativeregulationofcellpopulationproliferationproteinphosphorylation
Dehydrodolichyl diphosphate synthase complex subunit NUS1
9.4
77
32
DHDDSNGBRQ86SQ9Q96E22dolichyldiphosphatebiosyntheticprocesspolyprenolbiosyntheticprocessangiogenesiscelldifferentiationcholesterolhomeostasisdolicholbiosyntheticprocesspositiveregulationofbloodvesselendothelialcellmigrationpositiveregulationofnitric-oxidesynthaseactivityproteinglycosylationproteinmannosylationregulationofintracellularcholesteroltransportvascularendothelialgrowthfactorsignalingpathway
DNA polymerase subunit gamma-2, mitochondrial
9.5
61
36
DPOG1DPOG2P54098Q9UHN1base-excisionrepairgap-fillingDNAmetabolicprocessDNA-templatedDNAreplicationmitochondrialDNAreplicationinuteroembryonicdevelopmentmitochondrionmorphogenesispositiveregulationofDNA-directedDNApolymeraseactivityrespiratoryelectrontransportchain
EP300-interacting inhibitor of differentiation 1
9.6
73
36
RBL1EID1P28749Q9Y6B2cellcyclecelldifferentiationchromatinorganizationnegativeregulationofcellularsenescencenegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationoftranscriptionbyRNApolymeraseIIregulationoflipidkinaseactivitynegativeregulationofDNA-templatedtranscription
Succinate dehydrogenase assembly factor 2, mitochondrial
9.7
88
30
✔
SDHASDHF2P31040Q9NX18mitochondrialelectrontransportsuccinatetoubiquinonenervoussystemdevelopmentprotonmotiveforce-drivenmitochondrialATPsynthesisrespiratoryelectrontransportchainsuccinatemetabolicprocesstricarboxylicacidcyclemitochondrialrespiratorychaincomplexIIassemblynegativeregulationofcanonicalWntsignalingpathwaynegativeregulationofepithelialtomesenchymaltransitionproteindephosphorylationprotein-FADlinkage
Splicing factor 3B subunit 5
9.7
88
31
SF3B3SF3B5Q15393Q9BWJ5histoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationmRNAsplicingviaspliceosomenegativeregulationofproteincatabolicprocesspositiveregulationofDNA-templatedtranscriptionregulationofDNArepairregulationofRNAsplicingRNAsplicingRNAsplicingviatransesterificationreactionsU2-typeprespliceosomeassembly
Spindle and kinetochore-associated protein 2
9.7
63
39
SKA1SKA2Q96BD8Q8WVK7celldivisionchromosomesegregationmitoticcellcycleregulationofmicrotubulepolymerizationordepolymerization
Apoptosis regulator BAX
9.7
67
36
✔
Q9DHU6BAXQ9DHU6Q07812suppressionbyvirusofhostapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticsignalingpathwayapoptoticmitochondrialchangesapoptoticprocessapoptoticprocessinvolvedinbloodvesselmorphogenesisapoptoticprocessinvolvedinembryonicdigitmorphogenesisapoptoticprocessinvolvedinmammaryglandinvolutionapoptoticsignalingpathwayBcellapoptoticprocessBcellhomeostasisBcellhomeostaticproliferationBcellnegativeselectionBcellreceptorapoptoticsignalingpathwaybloodvesselremodelingcalciumiontransportintocytosolcellularresponsetounfoldedproteincellularresponsetoUVcellularresponsetoviruscerebralcortexdevelopmentdevelopmentofsecondarysexualcharacteristicsectopicgermcellprogrammedcelldeathendoplasmicreticulumcalciumionhomeostasisepithelialcellapoptoticprocessestablishmentormaintenanceoftransmembraneelectrochemicalgradientextrinsicapoptoticsignalingpathwayextrinsicapoptoticsignalingpathwayinabsenceofligandextrinsicapoptoticsignalingpathwayviadeathdomainreceptorsfertilizationgermcelldevelopmentglycosphingolipidmetabolicprocesshomeostasisofnumberofcellswithinatissuehypothalamusdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwaybyp53classmediatorintrinsicapoptoticsignalingpathwayinresponsetoDNAdamageintrinsicapoptoticsignalingpathwayinresponsetoendoplasmicreticulumstresskidneydevelopmentmitochondrialfragmentationinvolvedinapoptoticprocessmitochondrialfusionmitochondrionmorphogenesismotorneuronapoptoticprocessmyeloidcellhomeostasisnegativeregulationofapoptoticsignalingpathwaynegativeregulationofendoplasmicreticulumcalciumionconcentrationnegativeregulationoffibroblastproliferationnegativeregulationofmitochondrialmembranepotentialnegativeregulationofneuronapoptoticprocessnegativeregulationofpeptidyl-serinephosphorylationnegativeregulationofproteinbindingneuronmigrationodontogenesisofdentin-containingtoothovarianfollicledevelopmentpeptidyl-serinephosphorylationpositiveregulationofapoptoticDNAfragmentationpositiveregulationofapoptoticprocesspositiveregulationofapoptoticprocessinvolvedinmammaryglandinvolutionpositiveregulationofBcellapoptoticprocesspositiveregulationofcalciumiontransportintocytosolpositiveregulationofdevelopmentalpigmentationpositiveregulationofendoplasmicreticulumunfoldedproteinresponsepositiveregulationofepithelialcellapoptoticprocesspositiveregulationofintrinsicapoptoticsignalingpathwaypositiveregulationofIRE1-mediatedunfoldedproteinresponsepositiveregulationofmotorneuronapoptoticprocesspositiveregulationofneuronapoptoticprocesspositiveregulationofprotein-containingcomplexassemblypositiveregulationofreleaseofcytochromecfrommitochondriapositiveregulationofreleaseofsequesteredcalciumionintocytosolpositiveregulationofreproductiveprocesspost-embryoniccamera-typeeyemorphogenesisproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwayregulationofapoptoticprocessregulationofcellcycleregulationofmammaryglandepithelialcellproliferationregulationofmitochondrialmembranepermeabilityinvolvedinprogrammednecroticcelldeathregulationofmitochondrialmembranepotentialregulationofnitrogenutilizationreleaseofcytochromecfrommitochondriareleaseofmatrixenzymesfrommitochondriareleaseofsequesteredcalciumionintocytosolresponsetoaxoninjuryresponsetogammaradiationresponsetosaltstressresponsetotoxicsubstanceretinadevelopmentincamera-typeeyeretinalcellprogrammedcelldeathSertolicellproliferationspermatiddifferentiationsupramolecularfiberorganizationTcellhomeostaticproliferationthymocyteapoptoticprocessvaginadevelopment
Transcription initiation factor TFIID subunit 9
9.8
74
32
TAF5TAF9Q15542Q16594DNA-templatedtranscriptioninitiationhistoneH3acetylationmonoubiquitinatedhistonedeubiquitinationmonoubiquitinatedhistoneH2AdeubiquitinationmRNAtranscriptionbyRNApolymeraseIIpositiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinphosphorylationregulationofDNArepairregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptioninitiationatRNApolymeraseIIpromoterboxC/DsnoRNPassemblycellularresponsetoDNAdamagestimulushistoneacetylationnegativeregulationofapoptoticprocessnegativeregulationofintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatornegativeregulationofproteasomalubiquitin-dependentproteincatabolicprocesspositiveregulationofresponsetocytokinestimuluspositiveregulationoftranscriptionbyRNApolymeraseIIproteinstabilizationregulationofDNA-templatedtranscriptionregulationofRNAsplicingresponsetointerleukin-1responsetoL-glutamate
BRISC complex subunit Abraxas 2
9.8
80
26
BRCC3ABRX2P46736Q15018celldivisioncellularresponsetoionizingradiationchromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationhistoneH2AmonoubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointpositiveregulationofDNArepairpositiveregulationofNLRP3inflammasomecomplexassemblyproteinautoubiquitinationproteindeubiquitinationproteinK63-linkeddeubiquitinationregulationofDNAdamagecheckpointregulationofDNArepairresponsetoionizingradiationresponsetoX-rayattachmentofspindlemicrotubulestokinetochorechromosomesegregationmitoticcellcyclemitoticspindleassemblyresponsetoischemia
Guanine nucleotide-binding protein G(t) subunit alpha-3
9.8
64
34
OPSDGNAT3P02699P0C7Q4absorptionofvisiblelightcellularresponsetolightstimulusdetectionoftemperaturestimulusinvolvedinthermoceptionGprotein-coupledreceptorsignalingpathwayphotoreceptorcellmaintenancephototransductionphototransductionvisiblelightproteinphosphorylationresponsetolightstimulusretinadevelopmentincamera-typeeyerhodopsinmediatedsignalingpathwaythermotaxisvisualperceptionadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaydetectionofchemicalstimulusinvolvedinsensoryperceptionofbittertastesensoryperceptionofsweettastesensoryperceptionofumamitaste
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
9.8
56
37
D0Q0E8F1RIQ4D0Q0E8F1RIQ4suppressionbyvirusofhostapoptoticprocessextrinsicapoptoticsignalingpathwayinabsenceofligandintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagemitochondrialfusionpositiveregulationofapoptoticprocessreleaseofcytochromecfrommitochondria
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
9.8
44
41
✔
SMCA4SMRD1P51532Q96GM5chromatinremodelingnegativeregulationofandrogenreceptorsignalingpathwaynegativeregulationofcelldifferentiationnegativeregulationofcellgrowthnegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuralretinadevelopmentnucleosomedisassemblypositiveregulationbyhostofviraltranscriptionpositiveregulationofcelldifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofDNA-templatedtranscriptionpositiveregulationofdouble-strandbreakrepairpositiveregulationofglucosemediatedsignalingpathwaypositiveregulationofmiRNAtranscriptionpositiveregulationofmyoblastdifferentiationpositiveregulationofstemcellpopulationmaintenancepositiveregulationofTcelldifferentiationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionofnucleolarlargerRNAbyRNApolymeraseIpositiveregulationofWntsignalingpathwayregulationofG0toG1transitionregulationofG1/Stransitionofmitoticcellcycleregulationofmitoticmetaphase/anaphasetransitionregulationofnucleotide-excisionrepairregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIpreinitiationcomplexassemblycellularresponsetofattyacidtranscriptioninitiation-coupledchromatinremodeling
5-hydroxytryptamine receptor 4
9.9
70
33
GNAI15HT4RP63096Q13639adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormoneadenylatecyclase-inhibitingserotoninreceptorsignalingpathwaychemicalsynaptictransmissionGprotein-coupledreceptorsignalingpathwaycoupledtocyclicnucleotidesecondmessengerregulationofappetite
Centromere protein W
9.9
60
32
CENPTCENPWQ96BT3Q5EE01celldivisionchromosomeorganizationchromosomesegregationkinetochoreassemblymitoticcellcycleCENP-Acontainingchromatinassembly
TATA-box-binding protein
9.9
54
39
BRF2TBPQ9HAW0P20226cellularresponsetooxidativestressDNA-templatedtranscriptioninitiationregulationoftranscriptionbyRNApolymeraseIIItranscriptionpreinitiationcomplexassemblymRNAtranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIproteinphosphorylationRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIItranscriptionbyRNApolymeraseIIItranscriptioninitiationatRNApolymeraseIIpromoter
Mediator of RNA polymerase II transcription subunit 26
9.9
75
31
MED4MED26Q9NPJ6O95402positiveregulationofDNA-templatedtranscriptionpositiveregulationoftranscriptionelongationbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressiontranscriptioninitiationatRNApolymeraseIIpromoter
Frataxin, mitochondrial
10.0
83
25
NFS1FRDAQ9Y697Q165952Fe-2Sclusterassembly4Fe-4Sclusterassemblyironincorporationintometallo-sulfurclusteriron-sulfurclusterassemblyMo-molybdopterincofactorbiosyntheticprocessmolybdopterincofactormetabolicprocessadultwalkingbehaviorcellularironionhomeostasiscellularresponsetohydrogenperoxideembryodevelopmentendinginbirthoregghatchinghemebiosyntheticprocessiontransportmitochondrionorganizationmusclecellcellularhomeostasisnegativeregulationofapoptoticprocessnegativeregulationofmulticellularorganismgrowthnegativeregulationoforgangrowthnegativeregulationofreleaseofcytochromecfrommitochondriaorgangrowthoxidativephosphorylationpositiveregulationofaconitatehydrataseactivitypositiveregulationofcatalyticactivitypositiveregulationofcellgrowthpositiveregulationofcellpopulationproliferationpositiveregulationoflyaseactivitypositiveregulationofsuccinatedehydrogenaseactivityproprioceptionproteinautoprocessingregulationofferrochelataseactivityresponsetoironion
NADH-ubiquinone oxidoreductase chain 4L
7.9
94
38
A9UIY5NU4LMA9UIY5P03903aerobicrespirationATPsynthesiscoupledelectrontransportprotonmotiveforce-drivenmitochondrialATPsynthesis
Centromere protein N
9.8
61
33
CENPLCENPNQ8N0S6Q96H22chromosomesegregationkinetochoreassembly
Ran GTPase-activating protein 1
2.0
78
82
✔
UBC9RAGP1P63279P46061celldivisionchromosomesegregationmitoticnuclearmembranereassemblynegativeregulationofDNA-templatedtranscriptionnegativeregulationoftranscriptionbyRNApolymeraseIInuclearexportpositiveregulationofcellmigrationpositiveregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofSUMOtransferaseactivityproteinmodificationprocessproteinsumoylationubiquitin-dependentproteincatabolicprocessactivationofGTPaseactivitycellularresponsetopeptidehormonestimuluscellularresponsetovasopressinnegativeregulationofproteinexportfromnucleusnucleocytoplasmictransportresponsetoaxoninjurysignaltransduction
GATOR complex protein NPRL3
6.4
53
62
NPRL2NPRL3Q8WTW4Q12980cellularresponsetoaminoacidstarvationnegativeregulationofkinaseactivitynegativeregulationofTORsignalingnegativeregulationofTORC1signalingpositiveregulationofautophagyaortamorphogenesiscardiacmuscletissuedevelopmentroofofmouthdevelopmentTORC1signalingventricularseptumdevelopment
Golgin subfamily A member 2
7.9
56
47
✔
GORS1GOGA2Q9BQQ3Q08379establishmentofproteinlocalizationtoplasmamembraneGolgiorganizationnegativeregulationofdendritemorphogenesisproteinN-linkedglycosylationproteintransportasymmetriccelldivisioncentrosomecycleendoplasmicreticulumtoGolgivesicle-mediatedtransportGolgidisassemblyGolgiribbonformationmeioticspindleassemblymicrotubulenucleationmitoticspindleassemblynegativeregulationofautophagynegativeregulationofproteinbindingpositiveregulationofproteinglycosylationproteinglycosylationproteinhomotetramerizationspindleassembly
Membrane protein
8.7
78
41
Q53Z42Q692E0Q53Z42Q692E0antigenprocessingandpresentationimmuneresponsemitigationofhostantiviraldefenseresponse
Apoptosis-inducing factor 3
10.0
77
29
NMT1AIFM3P30419Q96NN9cellularketonemetabolicprocessinuteroembryonicdevelopmentN-terminalpeptidyl-glycineN-myristoylationN-terminalproteinmyristoylationpositiveregulationofproteininsertionintomitochondrialmembraneinvolvedinapoptoticsignalingpathwayregulationofrhodopsinmediatedsignalingpathwayexecutionphaseofapoptosis
TRAF family member-associated NF-kappa-B activator
4.9
nan
67
TRAF3TANKQ13114Q92844apoptoticprocessdefenseresponsetovirusnegativeregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofJNKcascadeproteinK63-linkedubiquitinationregulationofapoptoticprocessregulationofcytokineproductionregulationofdefenseresponsetovirusregulationofI-kappaBkinase/NF-kappaBsignalingregulationofinterferon-betaproductionregulationofproteolysissignaltransductionTollsignalingpathwaytoll-likereceptorsignalingpathwayTRIF-dependenttoll-likereceptorsignalingpathwaytumornecrosisfactor-mediatedsignalingpathwaytypeIinterferon-mediatedsignalingpathwaycellularresponsetoDNAdamagestimuluscellularresponsetointerleukin-1cellularresponsetoionizingradiationcellularresponsetotumornecrosisfactorI-kappaBkinase/NF-kappaBsignalingnegativeregulationofI-kappaBkinase/NF-kappaBsignalingpositiveregulationofproteindeubiquitinationpositiveregulationofubiquitin-specificproteaseactivity
Claspin
5.7
nan
66
CHK1CLSPNO14757Q9HAW4apoptoticprocessapoptoticprocessinvolvedindevelopmentcellularresponsetocaffeinecellularresponsetoDNAdamagestimuluscellularresponsetomechanicalstimulusDNAdamagecheckpointsignalingDNArepairDNAreplicationG2/MtransitionofmitoticcellcycleinnercellmasscellproliferationintracellularsignaltransductionmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointnegativeregulationofDNAbiosyntheticprocessnegativeregulationofG0toG1transitionnegativeregulationofmitoticnucleardivisionnucleusorganizationpeptidyl-threoninephosphorylationpositiveregulationofcellcycleproteinphosphorylationregulationofcellpopulationproliferationregulationofdouble-strandbreakrepairviahomologousrecombinationregulationofhistoneH3-K9acetylationregulationofmitoticcentrosomeseparationregulationofsignaltransductionbyp53classmediatorregulationoftranscriptionfromRNApolymeraseIIpromoterinresponsetoUV-inducedDNAdamagereplicativesenescencesignaltransductioninresponsetoDNAdamagetranscriptioninitiation-coupledchromatinremodelingactivationofproteinkinaseactivityDNAreplicationcheckpointsignalingmitoticDNAreplicationcheckpointsignalingpeptidyl-serinephosphorylation
26S proteasome regulatory subunit 4
6.6
61
56
✔
PSMD2PRS4Q4FZT9P62193proteasome-mediatedubiquitin-dependentproteincatabolicprocessregulationofproteincatabolicprocessnegativeregulationofneurondeath
BSLF2/BMLF1 protein
8.7
87
38
Q8WLS4A7UMS0Q8WLS4A7UMS0regulationofDNA-templatedtranscription
Synaptobrevin homolog YKT6
3.6
nan
72
PGTB2YKT6P53611O15498proteingeranylgeranylationproteinmodificationprocessproteinprenylationvisualperceptionendoplasmicreticulumtoGolgivesicle-mediatedtransportproteintransportretrogradetransportendosometoGolgivesicledockinginvolvedinexocytosisvesicletargeting
Transcription initiation factor IIA subunit 2
8.6
72
38
TF2AAT2AGP52655P52657positiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptioninitiationbyRNApolymeraseIIRNApolymeraseIIpreinitiationcomplexassemblytranscriptionbyRNApolymeraseIItranscriptioninitiationatRNApolymeraseIIpromoter
5'-AMP-activated protein kinase subunit beta-1
8.9
51
48
AAPK1AAKB1Q13131Q9Y478autophagybileacidandbilesalttransportbileacidsignalingpathwayCAMKK-AMPKsignalingcascadecellularresponsetocalciumioncellularresponsetoethanolcellularresponsetoglucosestarvationcellularresponsetoglucosestimuluscellularresponsetohydrogenperoxidecellularresponsetohypoxiacellularresponsetonutrientlevelscellularresponsetoorganonitrogencompoundcellularresponsetooxidativestresscellularresponsetoprostaglandinEstimuluscellularresponsetoxenobioticstimuluscholesterolbiosyntheticprocesschromatinorganizationcoldacclimationenergyhomeostasisfattyacidbiosyntheticprocessfattyacidhomeostasisfattyacidoxidationglucosehomeostasisglucosemetabolicprocessintracellularsignaltransductionlipidbiosyntheticprocesslipiddropletdisassemblymotorbehaviornegativeregulationofapoptoticprocessnegativeregulationofgeneexpressionnegativeregulationofglucosylceramidebiosyntheticprocessnegativeregulationofhepatocyteapoptoticprocessnegativeregulationofinsulinreceptorsignalingpathwaynegativeregulationoflipidcatabolicprocessnegativeregulationofTORsignalingnegativeregulationoftubulindeacetylationneuroncellularhomeostasispositiveregulationofautophagypositiveregulationofcellpopulationproliferationpositiveregulationofcholesterolbiosyntheticprocesspositiveregulationofgeneexpressionpositiveregulationofglycolyticprocesspositiveregulationofmitochondrialtranscriptionpositiveregulationofpeptidyl-lysineacetylationpositiveregulationofproteinlocalizationpositiveregulationofproteintargetingtomitochondrionpositiveregulationofskeletalmuscletissuedevelopmentproteinlocalizationtolipiddropletproteinphosphorylationregulationofbileacidsecretionregulationofcircadianrhythmregulationofmicrotubulecytoskeletonorganizationregulationofpeptidyl-serinephosphorylationregulationofstressgranuleassemblyregulationofvesicle-mediatedtransportresponseto17alpha-ethynylestradiolresponsetoactivityresponsetocaffeineresponsetocamptothecinresponsetogammaradiationresponsetohypoxiaresponsetoUVrhythmicprocesssignaltransductionWntsignalingpathwaynaildevelopmentpositiveregulationofcold-inducedthermogenesis
GTPase KRas
4.0
72
76
FNTBRASKQ02293P01116cellpopulationproliferationfibroblastproliferationlipidmetabolicprocessnegativeregulationofcellpopulationproliferationpositiveregulationofcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofnitric-oxidesynthasebiosyntheticprocessproteinfarnesylationproteinprenylationregulationoffibroblastproliferationresponsetocytokineresponsetoinorganicsubstanceresponsetoorganiccycliccompoundwoundhealingactincytoskeletonorganizationendocrinesignalingepithelialtubebranchinginvolvedinlungmorphogenesisforebrainastrocytedevelopmentglialcellproliferationhomeostasisofnumberofcellswithinatissueMAPKcascadenegativeregulationofepithelialcelldifferentiationnegativeregulationofneuronapoptoticprocessneuronapoptoticprocesspositiveregulationofgeneexpressionpositiveregulationofglialcellproliferationpositiveregulationofproteinphosphorylationpositiveregulationofRacproteinsignaltransductionRacproteinsignaltransductionRasproteinsignaltransductionregulationoflong-termneuronalsynapticplasticityregulationofsynaptictransmissionGABAergicskeletalmusclecelldifferentiationstriatedmusclecelldifferentiationtypeIpneumocytedifferentiationvisuallearning
Cortistatin
4.4
52
73
MRGX2CORTQ96LB1O00230Gprotein-coupledreceptorsignalingpathwaymastcellactivationmastcelldegranulationpositiveregulationofcytokinesissensoryperceptionofpainsleepadenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwaychemicalsynaptictransmissionreplicationforkprocessingresolutionofmeioticrecombinationintermediates
ORF 73
8.6
nan
41
WDR5Q76SB0P61964Q76SB0gluconeogenesishistoneH3acetylationhistoneH3-K14acetylationhistoneH3-K4methylationhistoneH4-K16acetylationhistoneH4-K5acetylationhistoneH4-K8acetylationnegativeregulationofhistoneH3-K4methylationneuronprojectiondevelopmentpositiveregulationofDNA-templatedtranscriptionpositiveregulationofgluconeogenesispositiveregulationofhistoneH3-K4methylationregulationofcellcycleregulationofcelldivisionregulationofDNA-templatedtranscriptionregulationofdosagecompensationbyinactivationofXchromosomeregulationofembryonicdevelopmentregulationofhistonedeacetylationregulationoftranscriptionbyRNApolymeraseIIregulationoftubulindeacetylationskeletalsystemdevelopmenttranscriptioninitiation-coupledchromatinremodeling
E3 ubiquitin-protein ligase NEDD4-like
9.6
nan
43
1433GNED4LP61981Q96PU5cellularresponsetoinsulinstimulusnegativeregulationofproteinkinaseactivityproteintargetingregulationofneurondifferentiationregulationofsignaltransductionregulationofsynapticplasticitysignaltransductioncelldifferentiationiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransportnegativeregulationofpotassiumiontransmembranetransporteractivitynegativeregulationofproteinlocalizationtocellsurfacenegativeregulationofsodiumiontransmembranetransportnegativeregulationofsodiumiontransmembranetransporteractivitypositiveregulationofcaveolin-mediatedendocytosispositiveregulationofdendriteextensionproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK48-linkedubiquitinationproteinpolyubiquitinationproteinubiquitinationregulationofdendritemorphogenesisregulationofiontransmembranetransportregulationofmembranedepolarizationregulationofmembranepotentialregulationofmembranerepolarizationregulationofpotassiumiontransmembranetransporteractivityregulationofproteinstabilityregulationofsodiumiontransmembranetransportubiquitin-dependentproteincatabolicprocessventricularcardiacmusclecellactionpotential
Chymotrypsin/elastase isoinhibitor 1
7.6
80
49
CELA1ICE1P00772P07851proteolysisnegativeregulationofpeptidaseactivity
IkB-like protein
9.5
57
42
PP2BAIKBLQ08209O36972agingbraindevelopmentcalcineurin-mediatedsignalingcalcineurin-NFATsignalingcascadecalciumiontransportcardiacmusclehypertrophyinresponsetostresscellularresponsetoglucosestimulusdendritemorphogenesisdephosphorylationepidermisdevelopmentexcitatorypostsynapticpotentialG1/Stransitionofmitoticcellcyclekeratinocytedifferentiationmodulationofchemicalsynaptictransmissionmulticellularorganismalresponsetostressnegativeregulationofcalciumionimportacrossplasmamembranenegativeregulationofchromatinbindingnegativeregulationofdendritemorphogenesisnegativeregulationofgeneexpressionnegativeregulationofinsulinsecretionnegativeregulationofsignalingnegativeregulationofvoltage-gatedcalciumchannelactivitypeptidyl-serinedephosphorylationpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcardiacmusclehypertrophyinresponsetostresspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofconnectivetissuereplacementpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendocytosispositiveregulationofgeneexpressionpositiveregulationofglomerulusdevelopmentpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofsalivasecretionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvoltage-gatedcalciumchannelactivitypostsynapticmodulationofchemicalsynaptictransmissionproteindephosphorylationproteinimportintonucleusregulationofcellproliferationinvolvedinkidneymorphogenesisrenalfiltrationresponsetoamphetamineresponsetocalciumionskeletalmusclefiberdevelopmentskeletalmuscletissueregenerationTcellactivationtransitionbetweenfastandslowfiberwoundhealingsuppressionbyvirusofhostNF-kappaBcascade
60S ribosomal protein L8
2.0
74
81
RIOX1RL8Q9H6W3P62917chromatinorganizationhistoneH3-K36demethylationhistoneH3-K4demethylationnegativeregulationofDNA-templatedtranscriptionnegativeregulationofosteoblastdifferentiationcytoplasmictranslationtranslation
Superoxide dismutase 1 copper chaperone
3.9
74
77
✔
SODCCCS1P00441P40202aginganterogradeaxonaltransportapoptoticprocessauditoryreceptorcellstereociliumorganizationcellularironionhomeostasiscellularresponsetoATPcellularresponsetocadmiumioncellularresponsetopotassiumionectopicgermcellprogrammedcelldeathembryoimplantationglutathionemetabolicprocessheartcontractionhydrogenperoxidebiosyntheticprocesslocomotorybehaviormusclecellcellularhomeostasismyeloidcellhomeostasisnegativeregulationofcholesterolbiosyntheticprocessnegativeregulationofdevelopmentalprocessnegativeregulationofinflammatoryresponsenegativeregulationofneuronapoptoticprocessnegativeregulationofreproductiveprocessneurofilamentcytoskeletonorganizationovarianfollicledevelopmentperipheralnervoussystemmyelinmaintenanceplacentadevelopmentpositiveregulationofapoptoticprocesspositiveregulationofcatalyticactivitypositiveregulationofcytokineproductionpositiveregulationofMAPKcascadepositiveregulationofoxidativestress-inducedintrinsicapoptoticsignalingpathwaypositiveregulationofphagocytosispositiveregulationofsuperoxideaniongenerationreactiveoxygenspeciesmetabolicprocessregulationofbloodpressureregulationofGTPaseactivityregulationofmitochondrialmembranepotentialregulationofmulticellularorganismgrowthregulationoforgangrowthregulationofproteinkinaseactivityregulationofTcelldifferentiationinthymusrelaxationofvascularassociatedsmoothmuscleremovalofsuperoxideradicalsresponsetoamphetamineresponsetoantibioticresponsetoantipsychoticdrugresponsetoaxoninjuryresponsetocarbonmonoxideresponsetocopperionresponsetoethanolresponsetoheatresponsetohydrogenperoxideresponsetonutrientlevelsresponsetoorganicsubstanceresponsetosuperoxideresponsetoxenobioticstimulusretinahomeostasisretrogradeaxonaltransportsensoryperceptionofsoundspermatogenesissuperoxideaniongenerationsuperoxidemetabolicprocessthymusdevelopmenttransmissionofnerveimpulsecopperiontransportproteinmaturationbycopperiontransfer
Protein Vpx
4.1
89
64
DCAF1VPXQ9Y4B6P19508BcelldifferentiationcellcompetitioninamulticellularorganismchromatinorganizationnegativeregulationoftranscriptionbyRNApolymeraseIIphosphorylationpost-translationalproteinmodificationproteinubiquitinationV(D)Jrecombinationsuppressionbyvirusofhostinnateimmuneresponsevirallifecycle
Effector protein NleF
5.4
90
52
CASP9NLEFP55211Q8XAL7activationofcysteine-typeendopeptidaseactivityactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessactivationofcysteine-typeendopeptidaseactivityinvolvedinapoptoticprocessbycytochromecagingapoptoticprocesscellularresponsetodexamethasonestimuluscellularresponsetoDNAdamagestimuluscellularresponsetoUVepithelialcellapoptoticprocessfibroblastapoptoticprocessglialcellapoptoticprocessintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagekidneydevelopmentleukocyteapoptoticprocessneuronapoptoticprocessplateletformationpositiveregulationofapoptoticprocesspositiveregulationofneuronapoptoticprocessregulationofresponsetoDNAdamagestimulusresponsetoantibioticresponsetocobaltionresponsetoestradiolresponsetoischemiaresponsetolipopolysaccharidesignaltransductioninresponsetoDNAdamagenegativeregulationofpeptidaseactivity
G-protein coupled receptor homolog US28
6.4
72
48
GNAI1US28P63096P69332adenylatecyclase-inhibitingGprotein-coupledreceptorsignalingpathwayadenylatecyclase-modulatingGprotein-coupledreceptorsignalingpathwaycellcyclecelldivisioncellularresponsetoforskolinGprotein-coupledreceptorsignalingpathwaypositiveregulationofproteinlocalizationtocellcortexregulationofcAMP-mediatedsignalingregulationofmitoticspindleorganizationresponsetopeptidehormonechemotaxisevasionofhostimmuneresponseviamodulationofhostcytokinenetworkmitigationofhostantiviraldefenseresponsepositiveregulationbyvirusofhostcelldivision
Viral macrophage inflammatory protein 2
6.7
68
56
CXCR4VMI2P61073Q98157apoptoticprocessbraindevelopmentcalcium-mediatedsignalingcardiacmusclecontractioncellchemotaxiscellularresponsetocytokinestimuluscellularresponsetoorganonitrogencompoundcellularresponsetoxenobioticstimulusCXCL12-activatedCXCR4signalingpathwaydendriticcellchemotaxisdetectionofmechanicalstimulusinvolvedinsensoryperceptionofpaindetectionoftemperaturestimulusinvolvedinsensoryperceptionofpainendothelialcelldifferentiationendothelialtubemorphogenesisepithelialcelldevelopmentGprotein-coupledreceptorsignalingpathwayimmuneresponseinflammatoryresponsemyelinmaintenanceneurogenesisneuronmigrationneuronrecognitionpositiveregulationofcellmigrationpositiveregulationofchemotaxispositiveregulationofcold-inducedthermogenesispositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofdendriteextensionpositiveregulationofmacrophagemigrationinhibitoryfactorsignalingpathwaypositiveregulationofmesenchymalstemcellmigrationpositiveregulationofoligodendrocytedifferentiationpositiveregulationofvascularwoundhealingregulationofcalciumiontransportregulationofcelladhesionregulationofchemotaxisregulationofprogrammedcelldeathregulationofviralprocessresponsetoactivityresponsetohypoxiaresponsetomorphineresponsetotacrolimusresponsetoultrasoundresponsetovirustelencephaloncellmigration
Trypsin inhibitor 1
7.4
72
52
KLK4SFTI1Q9Y5K2Q4GWU5amelogenesisbiomineraltissuedevelopmentextracellularmatrixdisassemblyproteolysisnegativeregulationofendopeptidaseactivity
Complement inhibitor RaCI1
8.8
78
41
CO5C5I1P01031A0A158RFT5cellsurfacereceptorsignalingpathwaychemotaxiscomplementactivationcomplementactivationalternativepathwaycomplementactivationclassicalpathwaycytolysisGprotein-coupledreceptorsignalingpathwayinuteroembryonicdevelopmentinflammatoryresponsenegativeregulationofmacrophagechemotaxispositiveregulationofangiogenesispositiveregulationofchemokineproductionpositiveregulationofimmuneresponsepositiveregulationofvascularendothelialgrowthfactorproduction
PI-stichotoxin-She2a
8.0
102
43
CELA1VKT1P00772P31713proteolysisnegativeregulationofpeptidaseactivity
Omega-conotoxin MVIIA
9.4
nan
47
CAC1BO17AQ00975P05484calciumionimportacrossplasmamembranechemicalsynaptictransmissionmodulationofchemicalsynaptictransmissionregulationofiontransmembranetransportresponsetoamyloid-beta
Alpha-bungarotoxin isoform V31
9.9
43
40
G5E9G93L21VG5E9G9P60616
Sarafotoxin
10.0
73
36
EDNRBSRTXP24530P13208agingaldosteronemetabolicprocesscalciumiontransmembranetransportcalcium-mediatedsignalingcanonicalWntsignalingpathwaycellsurfacereceptorsignalingpathwaycellularresponsetolipopolysaccharidecGMP-mediatedsignalingdevelopmentalpigmentationendothelinreceptorsignalingpathwayentericnervoussystemdevelopmententericsmoothmusclecelldifferentiationepithelialfluidtransportestablishmentofendothelialbarriergeneexpressionheparinmetabolicprocessI-kappaBkinase/NF-kappaBsignalingmacrophagechemotaxismelanocytedifferentiationnegativeregulationofadenylatecyclaseactivitynegativeregulationofapoptoticprocessnegativeregulationofneuronmaturationnegativeregulationofproteinmetabolicprocessnegativeregulationoftranscriptionbyRNApolymeraseIInervoussystemdevelopmentneuralcrestcellmigrationneuroblastmigrationperipheralnervoussystemdevelopmentpharynxdevelopmentphospholipaseC-activatingGprotein-coupledreceptorsignalingpathwaypodocytedifferentiationpositiveregulationofcellpopulationproliferationpositiveregulationofcytosoliccalciumionconcentrationpositiveregulationofpenileerectionpositiveregulationofproteinphosphorylationpositiveregulationofrenalsodiumexcretionpositiveregulationofurinevolumeposteriormidgutdevelopmentproteintransmembranetransportregulationofepithelialcellproliferationregulationoffevergenerationregulationofheartrateregulationofpHregulationofsensoryperceptionofpainrenalalbuminabsorptionrenalsodiumexcretionrenalsodiumionabsorptionreninsecretionintobloodstreamresponsetoendothelinresponsetoorganiccycliccompoundresponsetopainresponsetosodiumphosphatesensoryperceptionofpainvasoconstrictionvasodilationveinsmoothmusclecontractionregulationofvasoconstriction
Proteasome activator complex subunit 2
2.0
nan
88
✔
PSME1PSME2P97371P97372antigenprocessingandpresentationofexogenousantigenpositiveregulationofendopeptidaseactivityregulationofG1/Stransitionofmitoticcellcycleregulationofproteasomalproteincatabolicprocess
Genome polyprotein
8.3
nan
52
✔
HLAAPOLGP01892Q03463antibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-dependentantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-independentantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassICD8-positivealpha-betaTcellactivationdefenseresponsetoGram-positivebacteriumdetectionofbacteriumimmuneresponseinnateimmuneresponsepositiveregulationofCD8-positivealpha-betaTcellactivationpositiveregulationofCD8-positivealpha-betaTcellproliferationpositiveregulationofmemoryTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftypeIIinterferonproductionprotectionfromnaturalkillercellmediatedcytotoxicityTcellmediatedcytotoxicityTcellmediatedcytotoxicitydirectedagainsttumorcelltargetTcellreceptorsignalingpathwayclathrin-dependentendocytosisofvirusbyhostcellfusionofvirusmembranewithhostendosomemembraneinductionbyvirusofhostautophagymodulationbyvirusofhostG1/StransitioncheckpointnegativeregulationofERK1andERK2cascadenegativeregulationofinterferon-alphaproductionnegativeregulationofinterleukin-6productionnegativeregulationofMyD88-dependenttoll-likereceptorsignalingpathwaynegativeregulationoftoll-likereceptor2signalingpathwaynegativeregulationoftoll-likereceptor4signalingpathwaynegativeregulationoftoll-likereceptor7signalingpathwaynegativeregulationoftoll-likereceptor9signalingpathwayporeformationbyvirusinmembraneofhostcellpositiveregulationbysymbiontofhosttranscriptionpositiveregulationofDNAbindingpositiveregulationofinterferon-betaproductionpositiveregulationoftriglyceridebiosyntheticprocessproteincomplexoligomerizationproteolysissuppressionbyvirusofhostJAK-STATcascadeviainhibitionofSTAT1activitysuppressionbyvirusofhostPKRsignalingsuppressionbyvirusofhostTRAF-mediatedsignaltransductionsuppressionbyvirusofhosttranscriptionsuppressionbyvirusofhosttypeIinterferon-mediatedsignalingpathwaysuppressionbyvirusofhostviral-inducedcytoplasmicpatternrecognitionreceptorsignalingpathwayviainhibitionofMAVSactivitytransformationofhostcellbyvirusviralRNAgenomereplicationvirionattachmenttohostcell
mRNA export factor ICP27 homolog
8.3
73
45
✔
HLAAICP27P01892Q3KSU1antibacterialhumoralresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-dependentantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-independentantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassICD8-positivealpha-betaTcellactivationdefenseresponsetoGram-positivebacteriumdetectionofbacteriumimmuneresponseinnateimmuneresponsepositiveregulationofCD8-positivealpha-betaTcellactivationpositiveregulationofCD8-positivealpha-betaTcellproliferationpositiveregulationofmemoryTcellactivationpositiveregulationofTcellcytokineproductionpositiveregulationofTcellmediatedcytotoxicitypositiveregulationoftypeIIinterferonproductionprotectionfromnaturalkillercellmediatedcytotoxicityTcellmediatedcytotoxicityTcellmediatedcytotoxicitydirectedagainsttumorcelltargetTcellreceptorsignalingpathwaymRNAtransportregulationofDNA-templatedtranscriptionsuppressionbyvirusofhostPKRsignalingsuppressionbyvirusofhosttypeIinterferon-mediatedsignalingpathway
GA-binding protein subunit beta-1
4.0
51
72
✔
GABPAGABP1Q00422Q00420blastocystformationcelldifferentiationcellularresponsetodopamineinuteroembryonicdevelopmentnegativeregulationofmegakaryocytedifferentiationnegativeregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofgeneexpressionpositiveregulationoftranscriptionbyRNApolymeraseIIregulationoftranscriptionbyRNApolymeraseIImitochondrionorganization
Cyclin-dependent kinase inhibitor 1
6.0
75
54
✔
CDK4CDN1AP11802P38936adiposetissuedevelopmentcelldivisioncellularresponsetoinsulinstimuluscellularresponsetointerleukin-4cellularresponsetoionomycincellularresponsetolipopolysaccharidecellularresponsetophorbol13-acetate12-myristateG1/StransitionofmitoticcellcyclepositiveregulationofcellpopulationproliferationpositiveregulationoffibroblastproliferationpositiveregulationofG2/MtransitionofmitoticcellcycleproteinphosphorylationregulationofcellcycleregulationofgeneexpressionregulationofinsulinreceptorsignalingpathwayregulationoflipidbiosyntheticprocessregulationoflipidcatabolicprocessregulationofmulticellularorganismgrowthregulationoftranscriptioninitiationbyRNApolymeraseIIregulationoftypeBpancreaticcellproliferationresponsetoxenobioticstimulussignaltransductioncellularresponsetoaminoacidstarvationcellularresponsetoDNAdamagestimuluscellularresponsetoextracellularstimuluscellularresponsetogammaradiationcellularresponsetoionizingradiationcellularresponsetoUV-BcellularsenescenceDNAdamageresponsesignaltransductionbyp53classmediatorresultingincellcyclearrestDNAdamageresponsesignaltransductionbyp53classmediatorresultingintranscriptionofp21classmediatorheartdevelopmentintrinsicapoptoticsignalingpathwayintrinsicapoptoticsignalingpathwayinresponsetoDNAdamagebyp53classmediatormitoticG2DNAdamagecheckpointsignalingnegativeregulationofcardiacmuscletissueregenerationnegativeregulationofcellgrowthnegativeregulationofcellpopulationproliferationnegativeregulationofcyclin-dependentproteinkinaseactivitynegativeregulationofcyclin-dependentproteinserine/threoninekinaseactivitynegativeregulationofDNAbiosyntheticprocessnegativeregulationofG1/StransitionofmitoticcellcyclenegativeregulationofgeneexpressionnegativeregulationofphosphorylationnegativeregulationofproteinbindingnegativeregulationofproteinphosphorylationnegativeregulationofvascularassociatedsmoothmusclecellproliferationpositiveregulationofBcellproliferationpositiveregulationofprogrammedcelldeathpositiveregulationofproteinkinaseactivitypositiveregulationofproteinphosphorylationpositiveregulationofreactiveoxygenspeciesmetabolicprocessproteinimportintonucleusRasproteinsignaltransductionregulationofcellcycleG1/Sphasetransitionregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationofG1/StransitionofmitoticcellcycleregulationofG2/Mtransitionofmitoticcellcyclereplicativesenescencestress-inducedprematuresenescencetissueregenerationwoundhealing
BRCA1-A complex subunit RAP80
9.8
83
33
ABRX1UIMC1Q8BPZ8Q5U5Q9attachmentofspindlemicrotubulestokinetochorechromatinorganizationdouble-strandbreakrepairhistoneH2AK63-linkeddeubiquitinationmitoticG2DNAdamagecheckpointsignalingmitoticG2/MtransitioncheckpointmitoticspindleassemblypositiveregulationofDNArepairproteinK63-linkeddeubiquitinationregulationofDNArepairresponsetoionizingradiationnegativeregulationofDNA-templatedtranscription
Hirustasin
7.4
90
49
KLKANTAP00752P80302regulationofsystemicarterialbloodpressurezymogenactivationnegativeregulationofcoagulationnegativeregulationofpeptidaseactivity
Dystonin
2.0
46
86
ITB4DYSTP16144Q03001autophagycelladhesioncelladhesionmediatedbyintegrincellmigrationcellmotilitycell-matrixadhesionfilopodiumassemblyhemidesmosomeassemblyintegrin-mediatedsignalingpathwaymesodermalcelldifferentiationnaildevelopmentperipheralnervoussystemmyelinformationresponsetowoundingskinmorphogenesistrophoblastcellmigrationcytoskeletonorganizationintermediatefilamentcytoskeletonorganizationmaintenanceofcellpolaritymicrotubulecytoskeletonorganizationretrogradeaxonaltransportwoundhealing
Lytic switch protein BZLF1
9.1
75
38
HLABBZLF1P30481Q3KSS8adaptiveimmuneresponseantigenprocessingandpresentationofendogenouspeptideantigenviaMHCclassIviaERpathwayTAP-independentdefenseresponsedetectionofbacteriumimmuneresponseinnateimmuneresponsepositiveregulationofTcellmediatedcytotoxicityprotectionfromnaturalkillercellmediatedcytotoxicityregulationofdendriticcelldifferentiationregulationofinterleukin-12productionregulationofinterleukin-6productionregulationofTcellanergymodulationbyvirusofhostG0/G1transitioncheckpoint
Myosin regulatory light chain 11
9.5
53
42
MYH4MYL11Q5SX39P97457musclecontractionresponsetoactivityimmuneresponseskeletalmuscletissuedevelopment
Protein Tat
3.8
51
74
✔
CCNT1TATO60563P04608cellcyclecelldivisionphosphorylationofRNApolymeraseIIC-terminaldomainserine2residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterphosphorylationofRNApolymeraseIIC-terminaldomainserine5residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinphosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulustranscriptionbyRNApolymeraseIIevasionofhostimmuneresponsemodulationbyvirusofhostchromatinorganizationnegativeregulationofpeptidyl-threoninephosphorylationpositiveregulationofviraltranscriptionsuppressionbyvirusofhosttranslationinitiationsuppressionbyvirusofhosttypeIinterferon-mediatedsignalingpathway
ELL-associated factor 1
8.6
nan
55
ELL2EAF1O00472Q96JC9positiveregulationoftranscriptionelongationbyRNApolymeraseIIsnRNAtranscriptionbyRNApolymeraseIItranscriptionelongationbyRNApolymeraseIIpromoterregulationoftranscriptionelongationbyRNApolymeraseII
Protein Tat
4.0
nan
86
✔
CCNT1A0A0C5HAL9O60563A0A0C5HAL9cellcyclecelldivisionphosphorylationofRNApolymeraseIIC-terminaldomainserine2residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterphosphorylationofRNApolymeraseIIC-terminaldomainserine5residuesinvolvedinpositiveregulationoftranscriptionelongationfromRNApolymeraseIIpromoterpositiveregulationbyhostofviraltranscriptionpositiveregulationofDNA-templatedtranscriptionelongationpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationoftranscriptionelongationbyRNApolymeraseIIproteinphosphorylationregulationofcyclin-dependentproteinserine/threoninekinaseactivityregulationoftranscriptionbyRNApolymeraseIIresponsetoxenobioticstimulustranscriptionbyRNApolymeraseIIpositiveregulationofviraltranscription
Calcipressin-1
2.0
nan
94
PP2BARCAN1Q08209P53805agingbraindevelopmentcalcineurin-mediatedsignalingcalcineurin-NFATsignalingcascadecalciumiontransportcardiacmusclehypertrophyinresponsetostresscellularresponsetoglucosestimulusdendritemorphogenesisdephosphorylationepidermisdevelopmentexcitatorypostsynapticpotentialG1/Stransitionofmitoticcellcyclekeratinocytedifferentiationmodulationofchemicalsynaptictransmissionmulticellularorganismalresponsetostressnegativeregulationofcalciumionimportacrossplasmamembranenegativeregulationofchromatinbindingnegativeregulationofdendritemorphogenesisnegativeregulationofgeneexpressionnegativeregulationofinsulinsecretionnegativeregulationofsignalingnegativeregulationofvoltage-gatedcalciumchannelactivitypeptidyl-serinedephosphorylationpositiveregulationofactivatedTcellproliferationpositiveregulationofcalcineurin-NFATsignalingcascadepositiveregulationofcalciumionimportacrossplasmamembranepositiveregulationofcardiacmusclehypertrophyinresponsetostresspositiveregulationofcelladhesionpositiveregulationofcellmigrationpositiveregulationofconnectivetissuereplacementpositiveregulationofDNA-bindingtranscriptionfactoractivitypositiveregulationofendocytosispositiveregulationofgeneexpressionpositiveregulationofglomerulusdevelopmentpositiveregulationofosteoblastdifferentiationpositiveregulationofosteoclastdifferentiationpositiveregulationofsalivasecretionpositiveregulationoftranscriptionbyRNApolymeraseIIpositiveregulationofvoltage-gatedcalciumchannelactivitypostsynapticmodulationofchemicalsynaptictransmissionproteindephosphorylationproteinimportintonucleusregulationofcellproliferationinvolvedinkidneymorphogenesisrenalfiltrationresponsetoamphetamineresponsetocalciumionskeletalmusclefiberdevelopmentskeletalmuscletissueregenerationTcellactivationtransitionbetweenfastandslowfiberwoundhealingcalcium-mediatedsignalinglocomotioninvolvedinlocomotorybehaviornegativeregulationofcalcineurin-NFATsignalingcascaderegulationofphosphoproteinphosphataseactivityresponsetoischemiaresponsetooxidativestressshort-termmemory
Cytochrome b-c1 complex subunit 8
9.9
52
37
CYBQCR8P00157P13271mitochondrialelectrontransportubiquinoltocytochromecrespiratoryelectrontransportchain
DNA fragmentation factor subunit alpha
5.2
64
65
✔
DFFBDFFAO54788O54786apoptoticchromosomecondensationapoptoticDNAfragmentationDNAcatabolicprocessnegativeregulationofapoptoticDNAfragmentationchaperone-mediatedproteinfoldingnegativeregulationofdeoxyribonucleaseactivitynegativeregulationofexecutionphaseofapoptosispositiveregulationofapoptoticprocessregulationofapoptoticprocessthymocyteapoptoticprocess
Insulin-1
3.0
nan
85
HA2DINS1P04228P01325adaptiveimmuneresponseantigenprocessingandpresentationantigenprocessingandpresentationofexogenouspeptideantigenviaMHCclassIIantigenprocessingandpresentationofpeptideantigennegativeregulationofTcellproliferationpeptideantigenassemblywithMHCclassIIproteincomplexpositiveregulationofTcellactivationpositiveregulationofTcelldifferentiationactivationofproteinkinaseBactivityacute-phaseresponsealpha-betaTcellactivationcellularresponsetoglucosestimulusfattyacidhomeostasisGprotein-coupledreceptorsignalingpathwayglucosehomeostasisglucosemetabolicprocessglucosetransmembranetransportinsulinreceptorsignalingpathwaynegativeregulationofacuteinflammatoryresponsenegativeregulationoffattyacidmetabolicprocessnegativeregulationoffeedingbehaviornegativeregulationofgeneexpressionnegativeregulationofglycogencatabolicprocessnegativeregulationoflipidcatabolicprocessnegativeregulationofNAD(P)Hoxidaseactivitynegativeregulationofproteincatabolicprocessnegativeregulationofproteinsecretionnegativeregulationofproteolysisnegativeregulationofreactiveoxygenspeciesbiosyntheticprocessnegativeregulationofrespiratoryburstinvolvedininflammatoryresponseneuronprojectionmaintenancenitricoxide-cGMP-mediatedsignalingpathwaypositiveregulationofcellpopulationproliferationpositiveregulationofcytokineproductionpositiveregulationofdendriticspinemaintenancepositiveregulationofgeneexpressionpositiveregulationofglucoseimportpositiveregulationofglycogenbiosyntheticprocesspositiveregulationofglycolyticprocesspositiveregulationofinsulinreceptorsignalingpathwaypositiveregulationofMAPKcascadepositiveregulationofmitoticnucleardivisionpositiveregulationofNF-kappaBtranscriptionfactoractivitypositiveregulationofnitricoxidemediatedsignaltransductionpositiveregulationofphosphatidylinositol3-kinasesignalingpositiveregulationofproteinkinaseBsignalingpositiveregulationofproteinlocalizationtonucleuspositiveregulationofproteinmetabolicprocesspositiveregulationofproteinsecretionpositiveregulationofrespiratoryburstreceptorinternalizationregulationofcellularaminoacidmetabolicprocessregulationofproteinlocalizationregulationofproteinlocalizationtoplasmamembraneregulationofproteinsecretionregulationoftransmembranetransporteractivityresponsetocAMPresponsetocytokineresponsetometforminvasodilationwoundhealing
Genome polyprotein
4.4
87
65
IGG1B9V0E2P0DOX5B9V0E2adaptiveimmuneresponseclathrin-dependentendocytosisofvirusbyhostcellfusionofvirusmembranewithhostendosomemembraneinductionbyvirusofhostautophagymodulationbyvirusofhostG1/StransitioncheckpointporeformationbyvirusinmembraneofhostcellproteincomplexoligomerizationproteolysissuppressionbyvirusofhostJAK-STATcascadeviainhibitionofSTAT1activitysuppressionbyvirusofhostTRAF-mediatedsignaltransductionsuppressionbyvirusofhosttypeIinterferon-mediatedsignalingpathwaysuppressionbyvirusofhostviral-inducedcytoplasmicpatternrecognitionreceptorsignalingpathwayviainhibitionofMAVSactivitytransformationofhostcellbyvirusviralRNAgenomereplicationvirionattachmenttohostcell
Ubiquitin-conjugating enzyme E2 2
6.5
63
56
UBBUBC2P0CG47P06104energyhomeostasisfatpaddevelopmentfemalegonaddevelopmentfemalemeiosisIhypothalamusgonadotrophin-releasinghormoneneurondevelopmentmalemeiosisImitochondriontransportalongmicrotubulemodification-dependentproteincatabolicprocessneuronprojectionmorphogenesispositiveregulationofintrinsicapoptoticsignalingpathwaybyp53classmediatorpositiveregulationofproteinmonoubiquitinationpositiveregulationofproteinubiquitinationproteinubiquitinationregulationofmitochondrialmembranepotentialregulationofneurondeathregulationofproteasomalproteincatabolicprocessseminiferoustubuledevelopmentcytoplasmproteinqualitycontrolbytheubiquitin-proteasomesystemDNAduplexunwindingDNArepairDNA-templatedtranscriptionterminationdouble-strandbreakrepairviahomologousrecombinationepigeneticregulationofgeneexpressionerror-freepostreplicationDNArepairerror-freetranslesionsynthesiserror-pronetranslesionsynthesishistonemonoubiquitinationhistoneubiquitinationmeioticDNAdouble-strandbreakformationmitoticG1DNAdamagecheckpointsignalingpositiveregulationoftranscriptionbyRNApolymeraseIIproteasome-mediatedubiquitin-dependentproteincatabolicprocessproteinK63-linkedubiquitinationproteinmonoubiquitinationproteinpolyubiquitinationregulationofdipeptidetransportsporulationresultinginformationofacellularsporestress-inducedhomeostaticallyregulatedproteindegradationpathwaysubtelomericheterochromatinformationtelomeremaintenanceviarecombinationtranscriptionbyRNApolymeraseIIubiquitin-dependentERADpathwayubiquitin-dependentproteincatabolicprocessubiquitin-dependentproteincatabolicprocessviatheN-endrulepathway
ICP27
7.4
34
60
ALRF2Q9J0X9Q9JJW6Q9J0X9mRNAexportfromnucleusmRNAprocessingmRNAtransportpositiveregulationofDNA-templatedtranscriptionelongationregulationofDNArecombinationreplicationforkprocessingRNAexportfromnucleusRNAsplicingviralmRNAexportfromhostcellnucleusproteinexportfromnucleusregulationofDNA-templatedtranscription
Last updated: 2024-11-21
If this tool was useful for finding a disulphide, please cite: