ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HCG40889, isoform CRA_b

Intramolecular
Cysteine 389 and cysteine 431
Cysteine 416 and cysteine 442
A redox-regulated disulphide may form within HCG40889, isoform CRA_b between cysteines 389 and 431 (371 and 413 respectively in this structure).

Details

Redox score ?
84
PDB code
6atg
Structure name
insights to complement factor h recruitment by the borrelial cspz protein as revealed by structural analysis
Structure deposition date
2017-08-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A024R962
Residue number A
389
Residue number B
431
Peptide name
HCG40889, isoform CRA_b

Ligandability

Cysteine 389 of HCG40889, isoform CRA_b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 431 of HCG40889, isoform CRA_b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HCG40889, isoform CRA_b between cysteines 416 and 442 (398 and 424 respectively in this structure).

Details

Redox score ?
83
PDB code
6atg
Structure name
insights to complement factor h recruitment by the borrelial cspz protein as revealed by structural analysis
Structure deposition date
2017-08-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A024R962
Residue number A
416
Residue number B
442
Peptide name
HCG40889, isoform CRA_b

Ligandability

Cysteine 416 of HCG40889, isoform CRA_b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 442 of HCG40889, isoform CRA_b

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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