ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a

Intramolecular
Cysteine 300 and cysteine 364
Cysteine 26 and cysteine 51
A redox-regulated disulphide may form within Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a between cysteines 300 and 364 (279 and 343 respectively in this structure).

Details

Redox score ?
85
PDB code
7cj2
Structure name
crystal structure of the fab antibody complexed with human ykl-40
Structure deposition date
2020-07-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A024R969
Residue number A
300
Residue number B
364
Peptide name
Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a

Ligandability

Cysteine 300 of Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 364 of Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a between cysteines 26 and 51 (5 and 30 respectively in this structure).

Details

Redox score ?
80
PDB code
7cj2
Structure name
crystal structure of the fab antibody complexed with human ykl-40
Structure deposition date
2020-07-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A024R969
Residue number A
26
Residue number B
51
Peptide name
Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a

Ligandability

Cysteine 26 of Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 51 of Chitinase 3-like 1 (Cartilage glycoprotein-39), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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