ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HECT-type E3 ubiquitin transferase

Intermolecular
Cysteine 4169 and cysteine 4169
A redox-regulated disulphide may form between two units of HECT-type E3 ubiquitin transferase at cysteines 4169 and 4169 (4184 and 4184 respectively in this structure).

Details

Redox score ?
85
PDB code
6xz1
Structure name
conjugate of the hect domain of huwe1 with ubiquitin
Structure deposition date
2020-01-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide A name
HECT-type E3 ubiquitin transferase
Peptide B name
HECT-type E3 ubiquitin transferase
Peptide A accession
A0A024R9Y3
Peptide B accession
A0A024R9Y3
Peptide A residue number
4169
Peptide B residue number
4169

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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