ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protocadherin related 15

Intramolecular
Cysteine 273 and cysteine 282
Cysteine 37 and cysteine 125
A redox-regulated disulphide may form within Protocadherin related 15 between cysteines 273 and 282 (247 and 256 respectively in this structure).

Details

Redox score ?
86
PDB code
6n2e
Structure name
crystal structure of human protocadherin-15 ec1-3 g16d n369d q370n and mouse cadherin-23 ec1-2 t15e
Structure deposition date
2018-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A087X1T6
Residue number A
273
Residue number B
282
Peptide name
Protocadherin related 15

Ligandability

Cysteine 273 of Protocadherin related 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Protocadherin related 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protocadherin related 15 between cysteines 37 and 125 (11 and 99 respectively in this structure).

Details

Redox score ?
85
PDB code
6mfo
Structure name
crystal structure of human protocadherin-15 ec1-3 g16d n369d q370n
Structure deposition date
2018-09-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A087X1T6
Residue number A
37
Residue number B
125
Peptide name
Protocadherin related 15

Ligandability

Cysteine 37 of Protocadherin related 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of Protocadherin related 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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