ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anti-lox-1 15C4 light chain

Intramolecular
Cysteine 43 and cysteine 112
Cysteine 158 and cysteine 218
A redox-regulated disulphide may form within Anti-lox-1 15C4 light chain between cysteines 43 and 112 (23 and 88 respectively in this structure).

Details

Redox score ?
80
PDB code
6mv5
Structure name
anti-pcsk9 fab 6e2 bound to the n-terminal peptide from pcsk9 (e32k)
Structure deposition date
2018-10-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A097PUG4
Residue number A
43
Residue number B
112
Peptide name
Anti-lox-1 15C4 light chain

Ligandability

Cysteine 43 of Anti-lox-1 15C4 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of Anti-lox-1 15C4 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-lox-1 15C4 light chain between cysteines 158 and 218 (134 and 194 respectively in this structure).

Details

Redox score ?
77
PDB code
6e4z
Structure name
anti-pcsk9 fab 6e2 bound to the modified n-terminal peptide from pcsk9
Structure deposition date
2018-07-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A097PUG4
Residue number A
158
Residue number B
218
Peptide name
Anti-lox-1 15C4 light chain

Ligandability

Cysteine 158 of Anti-lox-1 15C4 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Anti-lox-1 15C4 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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