Thyrotropin receptor
Intramolecular
Cysteine 24 and cysteine 31
Cysteine 301 and cysteine 390
Cysteine 283 and cysteine 398
Cysteine 494 and cysteine 569
Cysteine 29 and cysteine 41
Cysteine 284 and cysteine 408
Cysteine 29 and cysteine 31
Cysteine 548 and cysteine 549
Cysteine 599 and cysteine 600
Cysteine 598 and cysteine 599
More...Cysteine 283 and cysteine 284
Cysteine 31 and cysteine 41
Cysteine 283 and cysteine 408
Cysteine 398 and cysteine 408
Cysteine 284 and cysteine 398
Cysteine 598 and cysteine 600
Cysteine 636 and cysteine 672
7t9i R 24 R 31
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 24 and 31.
Details
Redox score ?
86
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
24
Residue number B
31
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 24 of Thyrotropin receptor
Cysteine 31 of Thyrotropin receptor
7t9i R 301 R 390
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 301 and 390.
Details
Redox score ?
85
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
301
Residue number B
390
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 301 of Thyrotropin receptor
Cysteine 390 of Thyrotropin receptor
7t9m R 283 R 398
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 283 and 398.
Details
Redox score ?
84
PDB code
7t9m
Structure name
human thyrotropin receptor bound by cs-17 inverse agonist fab/org 274179-0 antagonist
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
283
Residue number B
398
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 283 of Thyrotropin receptor
Cysteine 398 of Thyrotropin receptor
7t9n R 494 R 569
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 494 and 569.
Details
Redox score ?
84
PDB code
7t9n
Structure name
m22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
494
Residue number B
569
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 494 of Thyrotropin receptor
Cysteine 569 of Thyrotropin receptor
7t9n R 29 R 41
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 29 and 41.
Details
Redox score ?
81
PDB code
7t9n
Structure name
m22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
34
Peptide accession
A0A0A0MTJ0
Residue number A
29
Residue number B
41
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 29 of Thyrotropin receptor
Cysteine 41 of Thyrotropin receptor
7t9i R 284 R 408
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 284 and 408.
Details
Redox score ?
75
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
9
% buried
40
Peptide accession
A0A0A0MTJ0
Residue number A
284
Residue number B
408
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 284 of Thyrotropin receptor
Cysteine 408 of Thyrotropin receptor
7t9n R 29 R 31
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 29 and 31.
Details
Redox score ?
65
PDB code
7t9n
Structure name
m22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
8
Peptide accession
A0A0A0MTJ0
Residue number A
29
Residue number B
31
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 29 of Thyrotropin receptor
Cysteine 31 of Thyrotropin receptor
7t9i R 548 R 549
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 548 and 549.
Details
Redox score ?
61
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
44
Peptide accession
A0A0A0MTJ0
Residue number A
548
Residue number B
549
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 548 of Thyrotropin receptor
Cysteine 549 of Thyrotropin receptor
7t9i R 599 R 600
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 599 and 600. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
14
Peptide accession
A0A0A0MTJ0
Residue number A
599
Residue number B
600
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 599 of Thyrotropin receptor
Cysteine 600 of Thyrotropin receptor
7t9i R 598 R 599
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 598 and 599. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
14
Peptide accession
A0A0A0MTJ0
Residue number A
598
Residue number B
599
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 598 of Thyrotropin receptor
Cysteine 599 of Thyrotropin receptor
7t9m R 283 R 284
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 283 and 284. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7t9m
Structure name
human thyrotropin receptor bound by cs-17 inverse agonist fab/org 274179-0 antagonist
Structure deposition date
2021-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
283
Residue number B
284
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 283 of Thyrotropin receptor
Cysteine 284 of Thyrotropin receptor
7t9n R 31 R 41
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 31 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7t9n
Structure name
m22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
27
Peptide accession
A0A0A0MTJ0
Residue number A
31
Residue number B
41
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 31 of Thyrotropin receptor
Cysteine 41 of Thyrotropin receptor
7t9n R 283 R 408
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 283 and 408. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7t9n
Structure name
m22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
283
Residue number B
408
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 283 of Thyrotropin receptor
Cysteine 408 of Thyrotropin receptor
7t9i R 398 R 408
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 398 and 408. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
9
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
398
Residue number B
408
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 398 of Thyrotropin receptor
Cysteine 408 of Thyrotropin receptor
7t9n R 284 R 398
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 284 and 398. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7t9n
Structure name
m22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0A0MTJ0
Residue number A
284
Residue number B
398
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 284 of Thyrotropin receptor
Cysteine 398 of Thyrotropin receptor
7t9i R 598 R 600
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 598 and 600. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7t9i
Structure name
native human tsh bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
28
Peptide accession
A0A0A0MTJ0
Residue number A
598
Residue number B
600
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 598 of Thyrotropin receptor
Cysteine 600 of Thyrotropin receptor
7t9n R 636 R 672
A redox-regulated disulphide may form within Thyrotropin receptor between cysteines 636 and 672. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7t9n
Structure name
m22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure)
Structure deposition date
2021-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
84
Peptide accession
A0A0A0MTJ0
Residue number A
636
Residue number B
672
Peptide name
Thyrotropin receptor
Ligandability
Cysteine 636 of Thyrotropin receptor
Cysteine 672 of Thyrotropin receptor
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