ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell receptor alpha chain V region PHDS58

Intermolecular
Cysteine 213 and cysteine 127 of T-cell receptor beta-1 chain C region
Intramolecular
Cysteine 42 and cysteine 110
Cysteine 110 and cysteine 191
A redox-regulated disulphide may form between cysteine 213 of T-cell receptor alpha chain V region PHDS58 and cysteine 127 of T-cell receptor beta-1 chain C region (213 and 247 respectively in this structure).

Details

Redox score ?
77
PDB code
1g6r
Structure name
a functional hot spot for antigen recognition in a superagonist tcr/mhc complex
Structure deposition date
2000-11-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
T-cell receptor alpha chain V region PHDS58
Peptide B name
T-cell receptor beta-1 chain C region
Peptide A accession
P01738
Peptide B accession
P01852
Peptide A residue number
213
Peptide B residue number
127

Ligandability

Cysteine 213 of T-cell receptor alpha chain V region PHDS58

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of T-cell receptor beta-1 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 213 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within T-cell receptor alpha chain V region PHDS58 between cysteines 42 and 110 (22 and 90 respectively in this structure).

Details

Redox score ?
73
PDB code
1g6r
Structure name
a functional hot spot for antigen recognition in a superagonist tcr/mhc complex
Structure deposition date
2000-11-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
85
Minimum pKa ?
8
% buried
96
Peptide accession
P01738
Residue number A
42
Residue number B
110
Peptide name
T-cell receptor alpha chain V region PHDS58

Ligandability

Cysteine 42 of T-cell receptor alpha chain V region PHDS58

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of T-cell receptor alpha chain V region PHDS58

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell receptor alpha chain V region PHDS58 between cysteines 110 and 191 (141 and 191 respectively in this structure).

Details

Redox score ?
nan
PDB code
1g6r
Structure name
a functional hot spot for antigen recognition in a superagonist tcr/mhc complex
Structure deposition date
2000-11-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
7
% buried
74
Peptide accession
P01738
Residue number A
110
Residue number B
191
Peptide name
T-cell receptor alpha chain V region PHDS58

Ligandability

Cysteine 110 of T-cell receptor alpha chain V region PHDS58

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of T-cell receptor alpha chain V region PHDS58

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 in protein B could not be asigned to a Uniprot residue.
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