Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Intramolecular
Cysteine 148 and cysteine 213
Cysteine 37 and cysteine 167
Cysteine 56 and cysteine 72
Cysteine 203 and cysteine 228
Cysteine 178 and cysteine 192
Cysteine 141 and cysteine 241
Cysteine 141 and cysteine 178
6o21 A 136 A 201
A redox-regulated disulphide may form within Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a between cysteines 148 and 213 (136 and 201 respectively in this structure).
Details
Redox score ?
86
PDB code
6o21
Structure name
crystal structure of human klk4 in complex with cleaved sfti- fcqr(asn14)[1,14] inhibitor
Structure deposition date
2019-02-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFQ5
Residue number A
148
Residue number B
213
Peptide name
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Ligandability
Cysteine 148 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Cysteine 213 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
7jow E 22 E 157
A redox-regulated disulphide may form within Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a between cysteines 37 and 167 (22 and 157 respectively in this structure).
Details
Redox score ?
84
PDB code
7jow
Structure name
crystal structure of bbki complexed with human kallikrein 4
Structure deposition date
2020-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFQ5
Residue number A
37
Residue number B
167
Peptide name
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Ligandability
Cysteine 37 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Cysteine 167 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
7jos I 42 I 58
A redox-regulated disulphide may form within Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a between cysteines 56 and 72 (42 and 58 respectively in this structure).
Details
Redox score ?
79
PDB code
7jos
Structure name
crystal structure of bbki complexed with human kallikrein 4
Structure deposition date
2020-08-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
98
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFQ5
Residue number A
56
Residue number B
72
Peptide name
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Ligandability
Cysteine 56 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Cysteine 72 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
7jos M 191 M 220
A redox-regulated disulphide may form within Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a between cysteines 203 and 228 (191 and 220 respectively in this structure).
Details
Redox score ?
76
PDB code
7jos
Structure name
crystal structure of bbki complexed with human kallikrein 4
Structure deposition date
2020-08-07
Thiol separation (Å)
3
Half-sphere exposure sum ?
96
Minimum pKa ?
7
% buried
100
Peptide accession
A0A0C4DFQ5
Residue number A
203
Residue number B
228
Peptide name
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Ligandability
Cysteine 203 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Cysteine 228 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
7jow E 168 E 182
A redox-regulated disulphide may form within Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a between cysteines 178 and 192 (168 and 182 respectively in this structure).
Details
Redox score ?
74
PDB code
7jow
Structure name
crystal structure of bbki complexed with human kallikrein 4
Structure deposition date
2020-08-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
32
Peptide accession
A0A0C4DFQ5
Residue number A
178
Residue number B
192
Peptide name
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Ligandability
Cysteine 178 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Cysteine 192 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
7jow E 128 E 232
A redox-regulated disulphide may form within Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a between cysteines 141 and 241 (128 and 232 respectively in this structure).
Details
Redox score ?
68
PDB code
7jow
Structure name
crystal structure of bbki complexed with human kallikrein 4
Structure deposition date
2020-08-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
14
Peptide accession
A0A0C4DFQ5
Residue number A
141
Residue number B
241
Peptide name
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Ligandability
Cysteine 141 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Cysteine 241 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
7jow E 128 E 168
A redox-regulated disulphide may form within Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a between cysteines 141 and 178 (128 and 168 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7jow
Structure name
crystal structure of bbki complexed with human kallikrein 4
Structure deposition date
2020-08-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
16
Peptide accession
A0A0C4DFQ5
Residue number A
141
Residue number B
178
Peptide name
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Ligandability
Cysteine 141 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
Cysteine 178 of Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a
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