NPC1 like intracellular cholesterol transporter 1
Intramolecular
Cysteine 980 and cysteine 989
Cysteine 920 and cysteine 925
Cysteine 525 and cysteine 542
Cysteine 966 and cysteine 1024
Cysteine 967 and cysteine 993
Cysteine 471 and cysteine 485
Cysteine 811 and cysteine 812
Cysteine 757 and cysteine 1119
Cysteine 810 and cysteine 812
Cysteine 810 and cysteine 811
More...Cysteine 967 and cysteine 1024
Cysteine 966 and cysteine 967
Cysteine 967 and cysteine 980
Cysteine 485 and cysteine 486
Cysteine 989 and cysteine 993
Cysteine 980 and cysteine 993
Cysteine 471 and cysteine 486
Cysteine 966 and cysteine 993
7dfz A 980 A 989
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 980 and 989.
Details
Redox score ?
88
PDB code
7dfz
Structure name
cryo_em structure of delta n-npc1l1-eze
Structure deposition date
2020-11-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
980
Residue number B
989
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 980 of NPC1 like intracellular cholesterol transporter 1
Cysteine 989 of NPC1 like intracellular cholesterol transporter 1
7df8 A 920 A 925
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 920 and 925.
Details
Redox score ?
87
PDB code
7df8
Structure name
full length hnpc1l1-apo
Structure deposition date
2020-11-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
920
Residue number B
925
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 920 of NPC1 like intracellular cholesterol transporter 1
Cysteine 925 of NPC1 like intracellular cholesterol transporter 1
7dfw A 525 A 542
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 525 and 542.
Details
Redox score ?
82
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
525
Residue number B
542
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 525 of NPC1 like intracellular cholesterol transporter 1
Cysteine 542 of NPC1 like intracellular cholesterol transporter 1
7dfw A 966 A 1024
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 966 and 1024.
Details
Redox score ?
81
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
60
Peptide accession
A0A0C4DFX6
Residue number A
966
Residue number B
1024
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 966 of NPC1 like intracellular cholesterol transporter 1
Cysteine 1024 of NPC1 like intracellular cholesterol transporter 1
7dfz A 967 A 993
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 967 and 993.
Details
Redox score ?
81
PDB code
7dfz
Structure name
cryo_em structure of delta n-npc1l1-eze
Structure deposition date
2020-11-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
967
Residue number B
993
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 967 of NPC1 like intracellular cholesterol transporter 1
Cysteine 993 of NPC1 like intracellular cholesterol transporter 1
7dfz A 471 A 485
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 471 and 485.
Details
Redox score ?
81
PDB code
7dfz
Structure name
cryo_em structure of delta n-npc1l1-eze
Structure deposition date
2020-11-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
471
Residue number B
485
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 471 of NPC1 like intracellular cholesterol transporter 1
Cysteine 485 of NPC1 like intracellular cholesterol transporter 1
7dfw A 811 A 812
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 811 and 812.
Details
Redox score ?
75
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
5
Half-sphere exposure sum ?
36
Minimum pKa ?
9
% buried
0
Peptide accession
A0A0C4DFX6
Residue number A
811
Residue number B
812
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 811 of NPC1 like intracellular cholesterol transporter 1
Cysteine 812 of NPC1 like intracellular cholesterol transporter 1
7dfz A 757 A 1119
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 757 and 1119.
Details
Redox score ?
75
PDB code
7dfz
Structure name
cryo_em structure of delta n-npc1l1-eze
Structure deposition date
2020-11-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
79
Minimum pKa ?
8
% buried
83
Peptide accession
A0A0C4DFX6
Residue number A
757
Residue number B
1119
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 757 of NPC1 like intracellular cholesterol transporter 1
Cysteine 1119 of NPC1 like intracellular cholesterol transporter 1
7dfw A 810 A 812
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 810 and 812. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
30
Minimum pKa ?
9
% buried
0
Peptide accession
A0A0C4DFX6
Residue number A
810
Residue number B
812
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 810 of NPC1 like intracellular cholesterol transporter 1
Cysteine 812 of NPC1 like intracellular cholesterol transporter 1
7dfw A 810 A 811
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 810 and 811. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
A0A0C4DFX6
Residue number A
810
Residue number B
811
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 810 of NPC1 like intracellular cholesterol transporter 1
Cysteine 811 of NPC1 like intracellular cholesterol transporter 1
7dfw A 967 A 1024
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 967 and 1024. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
7
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
967
Residue number B
1024
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 967 of NPC1 like intracellular cholesterol transporter 1
Cysteine 1024 of NPC1 like intracellular cholesterol transporter 1
7dfz A 966 A 967
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 966 and 967. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7dfz
Structure name
cryo_em structure of delta n-npc1l1-eze
Structure deposition date
2020-11-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
966
Residue number B
967
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 966 of NPC1 like intracellular cholesterol transporter 1
Cysteine 967 of NPC1 like intracellular cholesterol transporter 1
7df8 A 967 A 980
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 967 and 980. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7df8
Structure name
full length hnpc1l1-apo
Structure deposition date
2020-11-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
967
Residue number B
980
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 967 of NPC1 like intracellular cholesterol transporter 1
Cysteine 980 of NPC1 like intracellular cholesterol transporter 1
7dfw A 485 A 486
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 485 and 486. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
485
Residue number B
486
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 485 of NPC1 like intracellular cholesterol transporter 1
Cysteine 486 of NPC1 like intracellular cholesterol transporter 1
7df8 A 989 A 993
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 989 and 993. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7df8
Structure name
full length hnpc1l1-apo
Structure deposition date
2020-11-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
989
Residue number B
993
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 989 of NPC1 like intracellular cholesterol transporter 1
Cysteine 993 of NPC1 like intracellular cholesterol transporter 1
7dfz A 980 A 993
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 980 and 993. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7dfz
Structure name
cryo_em structure of delta n-npc1l1-eze
Structure deposition date
2020-11-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
980
Residue number B
993
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 980 of NPC1 like intracellular cholesterol transporter 1
Cysteine 993 of NPC1 like intracellular cholesterol transporter 1
7dfw A 471 A 486
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 471 and 486. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7dfw
Structure name
cryo_em structure of delta n-npc1l1-clr
Structure deposition date
2020-11-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
471
Residue number B
486
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 471 of NPC1 like intracellular cholesterol transporter 1
Cysteine 486 of NPC1 like intracellular cholesterol transporter 1
7dfz A 966 A 993
A redox-regulated disulphide may form within NPC1 like intracellular cholesterol transporter 1 between cysteines 966 and 993. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7dfz
Structure name
cryo_em structure of delta n-npc1l1-eze
Structure deposition date
2020-11-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DFX6
Residue number A
966
Residue number B
993
Peptide name
NPC1 like intracellular cholesterol transporter 1
Ligandability
Cysteine 966 of NPC1 like intracellular cholesterol transporter 1
Cysteine 993 of NPC1 like intracellular cholesterol transporter 1
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