ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T cell receptor gamma variable 8

Intramolecular
Cysteine 41 and cysteine 113
Cysteine 151 and cysteine 216
A redox-regulated disulphide may form within T cell receptor gamma variable 8 between cysteines 41 and 113 (30 and 102 respectively in this structure).

Details

Redox score ?
81
PDB code
7lli
Structure name
stimulatory immune receptor protein complex
Structure deposition date
2021-02-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DH27
Residue number A
41
Residue number B
113
Peptide name
T cell receptor gamma variable 8

Ligandability

Cysteine 41 of T cell receptor gamma variable 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of T cell receptor gamma variable 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T cell receptor gamma variable 8 between cysteines 151 and 216.

Details

Redox score ?
nan
PDB code
7lli
Structure name
stimulatory immune receptor protein complex
Structure deposition date
2021-02-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0C4DH27
Residue number A
151
Residue number B
216
Peptide name
T cell receptor gamma variable 8

Ligandability

Cysteine 151 of T cell receptor gamma variable 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of T cell receptor gamma variable 8

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 in protein A could not be asigned to a Uniprot residue.
Cysteine 216 in protein B could not be asigned to a Uniprot residue.
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