ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein Tat

Intermolecular
Cysteine 261 of Cyclin-T1 and cysteine 27 L
Cysteine 261 of Cyclin-T1 and cysteine 30 L
Cysteine 261 of Cyclin-T1 and cysteine 25 L
A redox-regulated disulphide may form between cysteine 261 of Cyclin-T1 and cysteine 27 of Protein Tat.

Details

Redox score ?
86
PDB code
6cyt
Structure name
hiv-1 tar loop in complex with tat:aff4:p-tefb
Structure deposition date
2018-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
8
Peptide A name
Cyclin-T1
Peptide B name
Protein Tat
Peptide A accession
O60563
Peptide B accession
A0A0C5HAL9
Peptide A residue number
261
Peptide B residue number
27

Ligandability

Cysteine 261 of Cyclin-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 27 of Protein Tat

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 261 of Cyclin-T1 and cysteine 30 of Protein Tat.

Details

Redox score ?
82
PDB code
6cyt
Structure name
hiv-1 tar loop in complex with tat:aff4:p-tefb
Structure deposition date
2018-04-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
9
Peptide A name
Cyclin-T1
Peptide B name
Protein Tat
Peptide A accession
O60563
Peptide B accession
A0A0C5HAL9
Peptide A residue number
261
Peptide B residue number
30

Ligandability

Cysteine 261 of Cyclin-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 30 of Protein Tat

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 261 of Cyclin-T1 and cysteine 25 of Protein Tat.

Details

Redox score ?
74
PDB code
6cyt
Structure name
hiv-1 tar loop in complex with tat:aff4:p-tefb
Structure deposition date
2018-04-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
7
Peptide A name
Cyclin-T1
Peptide B name
Protein Tat
Peptide A accession
O60563
Peptide B accession
A0A0C5HAL9
Peptide A residue number
261
Peptide B residue number
25

Ligandability

Cysteine 261 of Cyclin-T1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 25 of Protein Tat

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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