ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

IgE L chain kappa

Intramolecular
Cysteine 42 and cysteine 112
Cysteine 158 and cysteine 218
A redox-regulated disulphide may form within IgE L chain kappa between cysteines 42 and 112 (23 and 88 respectively in this structure).

Details

Redox score ?
81
PDB code
1rih
Structure name
crystal structure of fab 14f7, a unique anti-tumor antibody specific for n-glycolyl gm3
Structure deposition date
2003-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0D5ZY64
Residue number A
42
Residue number B
112
Peptide name
IgE L chain kappa

Ligandability

Cysteine 42 of IgE L chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of IgE L chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IgE L chain kappa between cysteines 158 and 218 (134 and 194 respectively in this structure).

Details

Redox score ?
76
PDB code
1rih
Structure name
crystal structure of fab 14f7, a unique anti-tumor antibody specific for n-glycolyl gm3
Structure deposition date
2003-11-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0D5ZY64
Residue number A
158
Residue number B
218
Peptide name
IgE L chain kappa

Ligandability

Cysteine 158 of IgE L chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of IgE L chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: