ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TRIM15

Intramolecular
Cysteine 363 and cysteine 396
Cysteine 363 and cysteine 460
A redox-regulated disulphide may form within TRIM15 between cysteines 363 and 396. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7qs2
Structure name
crystal structure of b30
Structure deposition date
2022-01-12
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
76
Peptide accession
A0A0G2JJP1
Residue number A
363
Residue number B
396
Peptide name
TRIM15

Ligandability

Cysteine 363 of TRIM15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 396 of TRIM15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TRIM15 between cysteines 363 and 460. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7qs2
Structure name
crystal structure of b30
Structure deposition date
2022-01-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
72
Peptide accession
A0A0G2JJP1
Residue number A
363
Residue number B
460
Peptide name
TRIM15

Ligandability

Cysteine 363 of TRIM15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 460 of TRIM15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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