ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

T cell receptor beta constant 2

Intermolecular
Cysteine 94 of T cell receptor alpha chain constant and cysteine 131
Intramolecular
Cysteine 31 and cysteine 96
Cysteine 31 and cysteine 75
A redox-regulated disulphide may form between cysteine 94 of T cell receptor alpha chain constant and cysteine 131 of T cell receptor beta constant 2 (227 and 264 respectively in this structure).

Details

Redox score ?
85
PDB code
6jxr
Structure name
structure of human t cell receptor-cd3 complex
Structure deposition date
2019-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide A name
T cell receptor alpha chain constant
Peptide B name
T cell receptor beta constant 2
Peptide A accession
P01848
Peptide B accession
A0A0G2JMB4
Peptide A residue number
94
Peptide B residue number
131

Ligandability

Cysteine 94 of T cell receptor alpha chain constant

Cysteine 131 of T cell receptor beta constant 2

A redox-regulated disulphide may form within T cell receptor beta constant 2 between cysteines 31 and 96 (164 and 229 respectively in this structure).

Details

Redox score ?
77
PDB code
6jxr
Structure name
structure of human t cell receptor-cd3 complex
Structure deposition date
2019-04-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0G2JMB4
Residue number A
31
Residue number B
96
Peptide name
T cell receptor beta constant 2

Ligandability

Cysteine 31 of T cell receptor beta constant 2

Cysteine 96 of T cell receptor beta constant 2

A redox-regulated disulphide may form within T cell receptor beta constant 2 between cysteines 31 and 75 (42 and 110 respectively in this structure).

Details

Redox score ?
nan
PDB code
7fje
Structure name
cryo-em structure of a membrane protein(ll)
Structure deposition date
2021-08-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0G2JMB4
Residue number A
31
Residue number B
75
Peptide name
T cell receptor beta constant 2

Ligandability

Cysteine 31 of T cell receptor beta constant 2

Cysteine 75 of T cell receptor beta constant 2

Uncertain whether structure cysteine 42 has been assigned to correct residue.
Uncertain whether structure cysteine 110 has been assigned to correct residue.
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