ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig-like domain-containing protein

Intramolecular
Cysteine 20 and cysteine 85
Cysteine 20 and cysteine 199
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 20 and 85 (23 and 93 respectively in this structure).

Details

Redox score ?
79
PDB code
6oor
Structure name
structure of 1b1 bound to mouse cd1d
Structure deposition date
2019-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0G2JZW1
Residue number A
20
Residue number B
85
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 20 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 85 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 20 and 199 (139 and 199 respectively in this structure).

Details

Redox score ?
nan
PDB code
6oor
Structure name
structure of 1b1 bound to mouse cd1d
Structure deposition date
2019-04-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0G2JZW1
Residue number A
20
Residue number B
199
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 20 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 139 has been assigned to correct residue.
Cysteine 199 in protein B could not be asigned to a Uniprot residue.
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