ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kinesin family member 13B

Intramolecular
Cysteine 48 and cysteine 69
A redox-regulated disulphide may form within Kinesin family member 13B between cysteines 48 and 69 (61 and 82 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6a20
Structure name
crystal structure of auto-inhibited kinesin-3 kif13b
Structure deposition date
2018-06-08
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
48
Peptide accession
A0A0G2K8Z9
Residue number A
48
Residue number B
69
Peptide name
Kinesin family member 13B

Ligandability

Cysteine 48 of Kinesin family member 13B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 69 of Kinesin family member 13B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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