ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell receptor beta chain V region E1

Intramolecular
Cysteine 44 and cysteine 112
Cysteine 44 and cysteine 114
Cysteine 112 and cysteine 114
A redox-regulated disulphide may form within T-cell receptor beta chain V region E1 between cysteines 44 and 112 (23 and 92 respectively in this structure).

Details

Redox score ?
79
PDB code
1kb5
Structure name
murine t-cell receptor variable domain/fab complex
Structure deposition date
1997-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
P04214
Residue number A
44
Residue number B
112
Peptide name
T-cell receptor beta chain V region E1

Ligandability

Cysteine 44 of T-cell receptor beta chain V region E1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of T-cell receptor beta chain V region E1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell receptor beta chain V region E1 between cysteines 44 and 114 (23 and 94 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
1kb5
Structure name
murine t-cell receptor variable domain/fab complex
Structure deposition date
1997-04-06
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
nan
Peptide accession
P04214
Residue number A
44
Residue number B
114
Peptide name
T-cell receptor beta chain V region E1

Ligandability

Cysteine 44 of T-cell receptor beta chain V region E1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of T-cell receptor beta chain V region E1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T-cell receptor beta chain V region E1 between cysteines 112 and 114 (92 and 94 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
2ol3
Structure name
crystal structure of bm3
Structure deposition date
2007-01-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
nan
Peptide accession
P04214
Residue number A
112
Residue number B
114
Peptide name
T-cell receptor beta chain V region E1

Ligandability

Cysteine 112 of T-cell receptor beta chain V region E1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of T-cell receptor beta chain V region E1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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