ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Solute carrier family 26 member 9

Intramolecular
Cysteine 463 and cysteine 464
Cysteine 388 and cysteine 389
Cysteine 83 and cysteine 410
A redox-regulated disulphide may form within Solute carrier family 26 member 9 between cysteines 463 and 464. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
6rtc
Structure name
structure of murine solute carrier 26 family member a9 (slc26a9) anion transporter in the inward-facing state
Structure deposition date
2019-05-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
26
Peptide accession
A0A0R4J0F7
Residue number A
463
Residue number B
464
Peptide name
Solute carrier family 26 member 9

Ligandability

Cysteine 463 of Solute carrier family 26 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 464 of Solute carrier family 26 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 26 member 9 between cysteines 388 and 389. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6rtc
Structure name
structure of murine solute carrier 26 family member a9 (slc26a9) anion transporter in the inward-facing state
Structure deposition date
2019-05-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
A0A0R4J0F7
Residue number A
388
Residue number B
389
Peptide name
Solute carrier family 26 member 9

Ligandability

Cysteine 388 of Solute carrier family 26 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 389 of Solute carrier family 26 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 26 member 9 between cysteines 83 and 410. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6rtc
Structure name
structure of murine solute carrier 26 family member a9 (slc26a9) anion transporter in the inward-facing state
Structure deposition date
2019-05-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
38
Peptide accession
A0A0R4J0F7
Residue number A
83
Residue number B
410
Peptide name
Solute carrier family 26 member 9

Ligandability

Cysteine 83 of Solute carrier family 26 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 410 of Solute carrier family 26 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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