ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

RNA binding motif protein 5 isoform 1

Intramolecular
Cysteine 187 and cysteine 190
Cysteine 187 and cysteine 201
Cysteine 187 and cysteine 204
Cysteine 190 and cysteine 201
Cysteine 190 and cysteine 204
Cysteine 201 and cysteine 204
A redox-regulated disulphide may form within RNA binding motif protein 5 isoform 1 between cysteines 187 and 190 (96 and 99 respectively in this structure).

Details

Redox score ?
90
PDB code
7pdv
Structure name
crystal structure of rbm5 rrm1-zinc finger in complex with rna
Structure deposition date
2021-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
33
Minimum pKa ?
6
% buried
0
Peptide accession
A0A0S2Z549
Residue number A
187
Residue number B
190
Peptide name
RNA binding motif protein 5 isoform 1

Ligandability

Cysteine 187 of RNA binding motif protein 5 isoform 1

Cysteine 190 of RNA binding motif protein 5 isoform 1

A redox-regulated disulphide may form within RNA binding motif protein 5 isoform 1 between cysteines 187 and 201 (96 and 110 respectively in this structure).

Details

Redox score ?
87
PDB code
7pdv
Structure name
crystal structure of rbm5 rrm1-zinc finger in complex with rna
Structure deposition date
2021-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
6
% buried
16
Peptide accession
A0A0S2Z549
Residue number A
187
Residue number B
201
Peptide name
RNA binding motif protein 5 isoform 1

Ligandability

Cysteine 187 of RNA binding motif protein 5 isoform 1

Cysteine 201 of RNA binding motif protein 5 isoform 1

A redox-regulated disulphide may form within RNA binding motif protein 5 isoform 1 between cysteines 187 and 204 (96 and 113 respectively in this structure).

Details

Redox score ?
86
PDB code
7pdv
Structure name
crystal structure of rbm5 rrm1-zinc finger in complex with rna
Structure deposition date
2021-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
31
Minimum pKa ?
6
% buried
0
Peptide accession
A0A0S2Z549
Residue number A
187
Residue number B
204
Peptide name
RNA binding motif protein 5 isoform 1

Ligandability

Cysteine 187 of RNA binding motif protein 5 isoform 1

Cysteine 204 of RNA binding motif protein 5 isoform 1

A redox-regulated disulphide may form within RNA binding motif protein 5 isoform 1 between cysteines 190 and 201 (99 and 110 respectively in this structure).

Details

Redox score ?
83
PDB code
7pdv
Structure name
crystal structure of rbm5 rrm1-zinc finger in complex with rna
Structure deposition date
2021-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
15
Peptide accession
A0A0S2Z549
Residue number A
190
Residue number B
201
Peptide name
RNA binding motif protein 5 isoform 1

Ligandability

Cysteine 190 of RNA binding motif protein 5 isoform 1

Cysteine 201 of RNA binding motif protein 5 isoform 1

A redox-regulated disulphide may form within RNA binding motif protein 5 isoform 1 between cysteines 190 and 204 (99 and 113 respectively in this structure).

Details

Redox score ?
77
PDB code
7pdv
Structure name
crystal structure of rbm5 rrm1-zinc finger in complex with rna
Structure deposition date
2021-08-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
45
Minimum pKa ?
9
% buried
24
Peptide accession
A0A0S2Z549
Residue number A
190
Residue number B
204
Peptide name
RNA binding motif protein 5 isoform 1

Ligandability

Cysteine 190 of RNA binding motif protein 5 isoform 1

Cysteine 204 of RNA binding motif protein 5 isoform 1

A redox-regulated disulphide may form within RNA binding motif protein 5 isoform 1 between cysteines 201 and 204 (110 and 113 respectively in this structure).

Details

Redox score ?
70
PDB code
7pdv
Structure name
crystal structure of rbm5 rrm1-zinc finger in complex with rna
Structure deposition date
2021-08-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
49
Minimum pKa ?
8
% buried
5
Peptide accession
A0A0S2Z549
Residue number A
201
Residue number B
204
Peptide name
RNA binding motif protein 5 isoform 1

Ligandability

Cysteine 201 of RNA binding motif protein 5 isoform 1

Cysteine 204 of RNA binding motif protein 5 isoform 1

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