ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MAb 6H10 light chain

Intermolecular
Cysteine 155 of Ighg protein and cysteine 234
Intramolecular
Cysteine 43 and cysteine 108
Cysteine 154 and cysteine 214
A redox-regulated disulphide may form between cysteine 155 of Ighg protein and cysteine 234 of MAb 6H10 light chain (139 and 214 respectively in this structure).

Details

Redox score ?
90
PDB code
6u2f
Structure name
pcsk9-fab 7g7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl- wnlk(hr)igllr - nh2
Structure deposition date
2019-08-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Ighg protein
Peptide B name
MAb 6H10 light chain
Peptide A accession
Q569X1
Peptide B accession
A0A0U5BC76
Peptide A residue number
155
Peptide B residue number
234

Ligandability

Cysteine 155 of Ighg protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of MAb 6H10 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MAb 6H10 light chain between cysteines 43 and 108 (23 and 88 respectively in this structure).

Details

Redox score ?
79
PDB code
5ikc
Structure name
x-ray structure of the n-terminal domain of human doublecortin in complex with fab
Structure deposition date
2016-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0U5BC76
Residue number A
43
Residue number B
108
Peptide name
MAb 6H10 light chain

Ligandability

Cysteine 43 of MAb 6H10 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of MAb 6H10 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MAb 6H10 light chain between cysteines 154 and 214 (134 and 194 respectively in this structure).

Details

Redox score ?
77
PDB code
5ikc
Structure name
x-ray structure of the n-terminal domain of human doublecortin in complex with fab
Structure deposition date
2016-03-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A0U5BC76
Residue number A
154
Residue number B
214
Peptide name
MAb 6H10 light chain

Ligandability

Cysteine 154 of MAb 6H10 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 214 of MAb 6H10 light chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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