ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

MHC class I antigen

Intramolecular
Cysteine 128 and cysteine 191
Cysteine 230 and cysteine 286
A redox-regulated disulphide may form within MHC class I antigen between cysteines 128 and 191 (104 and 167 respectively in this structure).

Details

Redox score ?
82
PDB code
6ilg
Structure name
crystal structure of bat mhc class i ptal-n*01:01 for 2
Structure deposition date
2018-10-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A125R585
Residue number A
128
Residue number B
191
Peptide name
MHC class I antigen

Ligandability

Cysteine 128 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 191 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I antigen between cysteines 230 and 286 (206 and 262 respectively in this structure).

Details

Redox score ?
79
PDB code
6ilg
Structure name
crystal structure of bat mhc class i ptal-n*01:01 for 2
Structure deposition date
2018-10-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A125R585
Residue number A
230
Residue number B
286
Peptide name
MHC class I antigen

Ligandability

Cysteine 230 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: