ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Light chain kappa

Intramolecular
Cysteine 42 and cysteine 158
Cysteine 158 and cysteine 218
A redox-regulated disulphide may form within Light chain kappa between cysteines 42 and 158 (23 and 88 respectively in this structure).

Details

Redox score ?
79
PDB code
5vxr
Structure name
the antigen-binding fragment of mab24 in complex with a peptide from hepatitis c virus e2 epitope i (412-423)
Structure deposition date
2017-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A125T908
Residue number A
42
Residue number B
158
Peptide name
Light chain kappa

Ligandability

Cysteine 42 of Light chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of Light chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Light chain kappa between cysteines 158 and 218 (134 and 194 respectively in this structure).

Details

Redox score ?
77
PDB code
5vxr
Structure name
the antigen-binding fragment of mab24 in complex with a peptide from hepatitis c virus e2 epitope i (412-423)
Structure deposition date
2017-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A125T908
Residue number A
158
Residue number B
218
Peptide name
Light chain kappa

Ligandability

Cysteine 158 of Light chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Light chain kappa

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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