ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Macrophage migration inhibitory factor

Intramolecular
Cysteine 60 and cysteine 81
Cysteine 57 and cysteine 60
A redox-regulated disulphide may form within Macrophage migration inhibitory factor between cysteines 60 and 81 (59 and 80 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6ice
Structure name
crystal structure of hamster mif
Structure deposition date
2018-09-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
91
Peptide accession
A0A140EDM8
Residue number A
60
Residue number B
81
Peptide name
Macrophage migration inhibitory factor

Ligandability

Cysteine 60 of Macrophage migration inhibitory factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 81 of Macrophage migration inhibitory factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Macrophage migration inhibitory factor between cysteines 57 and 60 (56 and 59 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6ice
Structure name
crystal structure of hamster mif
Structure deposition date
2018-09-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
92
Peptide accession
A0A140EDM8
Residue number A
57
Residue number B
60
Peptide name
Macrophage migration inhibitory factor

Ligandability

Cysteine 57 of Macrophage migration inhibitory factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of Macrophage migration inhibitory factor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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