ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anti-vesicular stomatitis virus N VHH

Intramolecular
Cysteine 22 and cysteine 96
Cysteine 50 and cysteine 108
A redox-regulated disulphide may form within Anti-vesicular stomatitis virus N VHH between cysteines 22 and 96.

Details

Redox score ?
79
PDB code
5ukb
Structure name
vsv n protein in complex with inhibitory nanobody 1004
Structure deposition date
2017-01-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A192B6J5
Residue number A
22
Residue number B
96
Peptide name
Anti-vesicular stomatitis virus N VHH

Ligandability

Cysteine 22 of Anti-vesicular stomatitis virus N VHH

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Anti-vesicular stomatitis virus N VHH

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-vesicular stomatitis virus N VHH between cysteines 50 and 108.

Details

Redox score ?
nan
PDB code
6raf
Structure name
heterodimeric abc exporter tmrab in inward-facing narrow conformation under turnover conditions
Structure deposition date
2019-04-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A192B6J5
Residue number A
50
Residue number B
108
Peptide name
Anti-vesicular stomatitis virus N VHH

Ligandability

Cysteine 50 of Anti-vesicular stomatitis virus N VHH

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Anti-vesicular stomatitis virus N VHH

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 50 in protein A could not be asigned to a Uniprot residue.
Cysteine 108 in protein B could not be asigned to a Uniprot residue.
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