ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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protein-serine/threonine phosphatase

Intramolecular
Cysteine 90 and cysteine 146
A redox-regulated disulphide may form within protein-serine/threonine phosphatase between cysteines 90 and 146 (92 and 148 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6du2
Structure name
structure of scp1 d96n bound to rest-ps861/4 peptide
Structure deposition date
2018-06-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
100
Peptide accession
A0A1S2ZIN9
Residue number A
90
Residue number B
146
Peptide name
protein-serine/threonine phosphatase

Ligandability

Cysteine 90 of protein-serine/threonine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of protein-serine/threonine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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