ATP-binding cassette sub-family C member 8 isoform X2
Intramolecular
Cysteine 6 and cysteine 26
Cysteine 1150 and cysteine 1175
Cysteine 292 and cysteine 435
Cysteine 1175 and cysteine 1258
7w4p B 6 B 26
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 isoform X2 between cysteines 6 and 26.
Details
Redox score ?
80
PDB code
7w4p
Structure name
the structure of katp h175k mutant in closed state
Structure deposition date
2021-11-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A1U7R319
Residue number A
6
Residue number B
26
Peptide name
ATP-binding cassette sub-family C member 8 isoform X2
Ligandability
Cysteine 6 of ATP-binding cassette sub-family C member 8 isoform X2
Cysteine 26 of ATP-binding cassette sub-family C member 8 isoform X2
6jb3 B 1150 B 1175
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 isoform X2 between cysteines 1150 and 1175. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
6jb3
Structure name
structure of sur1 subunit bound with repaglinide
Structure deposition date
2019-01-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
82
Peptide accession
A0A1U7R319
Residue number A
1150
Residue number B
1175
Peptide name
ATP-binding cassette sub-family C member 8 isoform X2
Ligandability
Cysteine 1150 of ATP-binding cassette sub-family C member 8 isoform X2
Cysteine 1175 of ATP-binding cassette sub-family C member 8 isoform X2
7w4o D 292 D 435
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 isoform X2 between cysteines 292 and 435. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7w4o
Structure name
the structure of katp h175k mutant in pre-open state
Structure deposition date
2021-11-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
47
Peptide accession
A0A1U7R319
Residue number A
292
Residue number B
435
Peptide name
ATP-binding cassette sub-family C member 8 isoform X2
Ligandability
Cysteine 292 of ATP-binding cassette sub-family C member 8 isoform X2
Cysteine 435 of ATP-binding cassette sub-family C member 8 isoform X2
7w4p B 1175 B 1258
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 isoform X2 between cysteines 1175 and 1258. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7w4p
Structure name
the structure of katp h175k mutant in closed state
Structure deposition date
2021-11-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
52
Peptide accession
A0A1U7R319
Residue number A
1175
Residue number B
1258
Peptide name
ATP-binding cassette sub-family C member 8 isoform X2
Ligandability
Cysteine 1175 of ATP-binding cassette sub-family C member 8 isoform X2
Cysteine 1258 of ATP-binding cassette sub-family C member 8 isoform X2
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