ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Solute carrier family 40 member

Intramolecular
Cysteine 383 and cysteine 387
Cysteine 106 and cysteine 205
A redox-regulated disulphide may form within Solute carrier family 40 member between cysteines 383 and 387. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
6wik
Structure name
cryo-em structure of slc40/ferroportin with fab in the presence of hepcidin
Structure deposition date
2020-04-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
66
Peptide accession
A0A1U7U6F1
Residue number A
383
Residue number B
387
Peptide name
Solute carrier family 40 member

Ligandability

Cysteine 383 of Solute carrier family 40 member

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 387 of Solute carrier family 40 member

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 40 member between cysteines 106 and 205. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6wik
Structure name
cryo-em structure of slc40/ferroportin with fab in the presence of hepcidin
Structure deposition date
2020-04-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
76
Peptide accession
A0A1U7U6F1
Residue number A
106
Residue number B
205
Peptide name
Solute carrier family 40 member

Ligandability

Cysteine 106 of Solute carrier family 40 member

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of Solute carrier family 40 member

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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