ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-binding cassette sub-family C member 8 isoform X1

Intramolecular
Cysteine 1163 and cysteine 1188
Cysteine 305 and cysteine 448
A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 isoform X1 between cysteines 1163 and 1188 (1150 and 1175 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7wit
Structure name
structure of sur1 in complex with mitiglinide
Structure deposition date
2022-01-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
78
Peptide accession
A0A1U8CME7
Residue number A
1163
Residue number B
1188
Peptide name
ATP-binding cassette sub-family C member 8 isoform X1

Ligandability

Cysteine 1163 of ATP-binding cassette sub-family C member 8 isoform X1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1188 of ATP-binding cassette sub-family C member 8 isoform X1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-binding cassette sub-family C member 8 isoform X1 between cysteines 305 and 448 (292 and 435 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7wit
Structure name
structure of sur1 in complex with mitiglinide
Structure deposition date
2022-01-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
48
Peptide accession
A0A1U8CME7
Residue number A
305
Residue number B
448
Peptide name
ATP-binding cassette sub-family C member 8 isoform X1

Ligandability

Cysteine 305 of ATP-binding cassette sub-family C member 8 isoform X1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 448 of ATP-binding cassette sub-family C member 8 isoform X1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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