ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gamma-aminobutyric acid type A receptor subunit gamma2

Intramolecular
Cysteine 166 and cysteine 180
Cysteine 259 and cysteine 318
A redox-regulated disulphide may form within Gamma-aminobutyric acid type A receptor subunit gamma2 between cysteines 166 and 180 (151 and 165 respectively in this structure).

Details

Redox score ?
84
PDB code
7qna
Structure name
cryo-em structure of human full-length alpha4beta3gamma2 gaba(a)r in complex with gaba and nanobody nb25
Structure deposition date
2021-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A1W2PQX1
Residue number A
166
Residue number B
180
Peptide name
Gamma-aminobutyric acid type A receptor subunit gamma2

Ligandability

Cysteine 166 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gamma-aminobutyric acid type A receptor subunit gamma2 between cysteines 259 and 318 (244 and 303 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7qna
Structure name
cryo-em structure of human full-length alpha4beta3gamma2 gaba(a)r in complex with gaba and nanobody nb25
Structure deposition date
2021-12-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
97
Peptide accession
A0A1W2PQX1
Residue number A
259
Residue number B
318
Peptide name
Gamma-aminobutyric acid type A receptor subunit gamma2

Ligandability

Cysteine 259 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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