ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Gamma-aminobutyric acid receptor subunit gamma-2

Intramolecular
Cysteine 190 and cysteine 204
Cysteine 283 and cysteine 342
A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit gamma-2 between cysteines 190 and 204 (151 and 165 respectively in this structure).

Details

Redox score ?
85
PDB code
7qne
Structure name
cryo-em structure of human full-length synaptic alpha1beta3gamma2 gaba(a)r in complex with ro15-4513 and megabody mb38
Structure deposition date
2021-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A286YFI6
Residue number A
190
Residue number B
204
Peptide name
Gamma-aminobutyric acid receptor subunit gamma-2

Ligandability

Cysteine 190 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gamma-aminobutyric acid receptor subunit gamma-2 between cysteines 283 and 342 (244 and 303 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7qne
Structure name
cryo-em structure of human full-length synaptic alpha1beta3gamma2 gaba(a)r in complex with ro15-4513 and megabody mb38
Structure deposition date
2021-12-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
98
Peptide accession
A0A286YFI6
Residue number A
283
Residue number B
342
Peptide name
Gamma-aminobutyric acid receptor subunit gamma-2

Ligandability

Cysteine 283 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 342 of Gamma-aminobutyric acid receptor subunit gamma-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: