ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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RNA polymerase II subunit D

Intramolecular
Cysteine 141 and cysteine 146
A redox-regulated disulphide may form within RNA polymerase II subunit D between cysteines 141 and 146 (99 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6gml
Structure name
structure of paused transcription complex pol ii-dsif-nelf
Structure deposition date
2018-05-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
98
Peptide accession
A0A287ADR4
Residue number A
141
Residue number B
146
Peptide name
RNA polymerase II subunit D

Ligandability

Cysteine 141 of RNA polymerase II subunit D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of RNA polymerase II subunit D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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