ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Gamma-aminobutyric acid type A receptor subunit gamma2

Intramolecular
Cysteine 161 and cysteine 175
Cysteine 254 and cysteine 313
A redox-regulated disulphide may form within Gamma-aminobutyric acid type A receptor subunit gamma2 between cysteines 161 and 175 (151 and 165 respectively in this structure).

Details

Redox score ?
83
PDB code
7qnb
Structure name
cryo-em structure of human full-length beta3gamma2 gaba(a)r in complex with gaba and nanobody nb25
Structure deposition date
2021-12-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A2K5TLN2
Residue number A
161
Residue number B
175
Peptide name
Gamma-aminobutyric acid type A receptor subunit gamma2

Ligandability

Cysteine 161 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 175 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Gamma-aminobutyric acid type A receptor subunit gamma2 between cysteines 254 and 313 (244 and 303 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7qnb
Structure name
cryo-em structure of human full-length beta3gamma2 gaba(a)r in complex with gaba and nanobody nb25
Structure deposition date
2021-12-20
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
97
Peptide accession
A0A2K5TLN2
Residue number A
254
Residue number B
313
Peptide name
Gamma-aminobutyric acid type A receptor subunit gamma2

Ligandability

Cysteine 254 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of Gamma-aminobutyric acid type A receptor subunit gamma2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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