ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lymphocyte antigen HLA-B27

Intramolecular
Cysteine 125 and cysteine 188
Cysteine 227 and cysteine 283
A redox-regulated disulphide may form within Lymphocyte antigen HLA-B27 between cysteines 125 and 188 (101 and 164 respectively in this structure).

Details

Redox score ?
82
PDB code
7alo
Structure name
structure of b*27:09/photorl9
Structure deposition date
2020-10-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A2R7Z5J3
Residue number A
125
Residue number B
188
Peptide name
Lymphocyte antigen HLA-B27

Ligandability

Cysteine 125 of Lymphocyte antigen HLA-B27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of Lymphocyte antigen HLA-B27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lymphocyte antigen HLA-B27 between cysteines 227 and 283 (203 and 259 respectively in this structure).

Details

Redox score ?
80
PDB code
7alo
Structure name
structure of b*27:09/photorl9
Structure deposition date
2020-10-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A2R7Z5J3
Residue number A
227
Residue number B
283
Peptide name
Lymphocyte antigen HLA-B27

Ligandability

Cysteine 227 of Lymphocyte antigen HLA-B27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of Lymphocyte antigen HLA-B27

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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