ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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cathelicidin-1-like

Intramolecular
Cysteine 158 and cysteine 166
Cysteine 154 and cysteine 158
A redox-regulated disulphide may form within cathelicidin-1-like between cysteines 158 and 166 (3 and 23 respectively in this structure).

Details

Redox score ?
90
PDB code
7osc
Structure name
solution structure of antimicrobial peptide cathelicidin-1 pcdode from sperm whale physeter catodon
Structure deposition date
2021-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
18
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A2Y9FJE4
Residue number A
158
Residue number B
166
Peptide name
cathelicidin-1-like

Ligandability

Cysteine 158 of cathelicidin-1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 166 of cathelicidin-1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within cathelicidin-1-like between cysteines 154 and 158 (11 and 15 respectively in this structure).

Details

Redox score ?
90
PDB code
7osc
Structure name
solution structure of antimicrobial peptide cathelicidin-1 pcdode from sperm whale physeter catodon
Structure deposition date
2021-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
20
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A2Y9FJE4
Residue number A
154
Residue number B
158
Peptide name
cathelicidin-1-like

Ligandability

Cysteine 154 of cathelicidin-1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 158 of cathelicidin-1-like

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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