ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

G protein-activated inward rectifier potassium channel 2

Intramolecular
Cysteine 116 and cysteine 148
A redox-regulated disulphide may form within G protein-activated inward rectifier potassium channel 2 between cysteines 116 and 148 (134 and 166 respectively in this structure).

Details

Redox score ?
85
PDB code
6xev
Structure name
cryoem structure of girk2-pip2/chs - g protein-gated inwardly rectifying potassium channel girk2 with modulators cholesteryl hemisuccinate and pip2
Structure deposition date
2020-06-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A338P6L0
Residue number A
116
Residue number B
148
Peptide name
G protein-activated inward rectifier potassium channel 2

Ligandability

Cysteine 116 of G protein-activated inward rectifier potassium channel 2

Cysteine 148 of G protein-activated inward rectifier potassium channel 2

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