ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

DNA-directed RNA polymerase II subunit RPB4

Intramolecular
Cysteine 99 and cysteine 104
A redox-regulated disulphide may form within DNA-directed RNA polymerase II subunit RPB4 between cysteines 99 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7f4g
Structure name
structure of rpap2-bound rna polymerase ii
Structure deposition date
2021-06-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
88
Peptide accession
A0A481BYI6
Residue number A
99
Residue number B
104
Peptide name
DNA-directed RNA polymerase II subunit RPB4

Ligandability

Cysteine 99 of DNA-directed RNA polymerase II subunit RPB4

Cysteine 104 of DNA-directed RNA polymerase II subunit RPB4

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