ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hemoglobin subunit beta

Intermolecular
Cysteine 105 of Hemoglobin subunit alpha and cysteine 113
A redox-regulated disulphide may form between cysteine 105 of Hemoglobin subunit alpha and cysteine 113 of Hemoglobin subunit beta (104 and 112 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
7k4m
Structure name
crystal structure of metap2 modified hemoglobin s
Structure deposition date
2020-09-15
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide A name
Hemoglobin subunit alpha
Peptide B name
Hemoglobin subunit beta
Peptide A accession
P69905
Peptide B accession
A0A481SHK9
Peptide A residue number
105
Peptide B residue number
113

Ligandability

Cysteine 105 of Hemoglobin subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Hemoglobin subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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