ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Allergen lipocalin Cav p 1 isoform 1

Intramolecular
Cysteine 53 and cysteine 57
Cysteine 72 and cysteine 164
A redox-regulated disulphide may form within Allergen lipocalin Cav p 1 isoform 1 between cysteines 53 and 57 (36 and 40 respectively in this structure).

Details

Redox score ?
87
PDB code
8a0d
Structure name
crystal structure of the major guinea pig allergen cav p 1
Structure deposition date
2022-05-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A484HM70
Residue number A
53
Residue number B
57
Peptide name
Allergen lipocalin Cav p 1 isoform 1

Ligandability

Cysteine 53 of Allergen lipocalin Cav p 1 isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 57 of Allergen lipocalin Cav p 1 isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Allergen lipocalin Cav p 1 isoform 1 between cysteines 72 and 164 (55 and 147 respectively in this structure).

Details

Redox score ?
86
PDB code
8a0d
Structure name
crystal structure of the major guinea pig allergen cav p 1
Structure deposition date
2022-05-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A484HM70
Residue number A
72
Residue number B
164
Peptide name
Allergen lipocalin Cav p 1 isoform 1

Ligandability

Cysteine 72 of Allergen lipocalin Cav p 1 isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 164 of Allergen lipocalin Cav p 1 isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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