a tool for identifying drug-targetable redox-active disulphides

AEP5A5

Intramolecular

Cysteine 24 and cysteine 98

A redox-regulated disulphide may form within AEP5A5 between cysteines 24 and 98 (22 and 97 respectively in this structure).

Details

Redox score ?

81

PDB code

Structure name

crystal structure of human rhob-gtp in complex with nanobody b6

Structure deposition date

2019-08-04

Thiol separation (Å)

2

Half-sphere exposure sum ?

86

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

24

Residue number B

98

Peptide name

AEP5A5

Ligandability

Cysteine 24 of AEP5A5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of AEP5A5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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