ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Thyroglobulin

Intramolecular
Cysteine 408 and cysteine 608
Cysteine 1930 and cysteine 1941
Cysteine 901 and cysteine 922
Cysteine 1479 and cysteine 1493
Cysteine 1496 and cysteine 1513
Cysteine 1517 and cysteine 1526
Cysteine 1216 and cysteine 1265
Cysteine 1150 and cysteine 1170
Cysteine 1232 and cysteine 1246
Cysteine 926 and cysteine 1032
More...
Cysteine 2136 and cysteine 2142
Cysteine 1078 and cysteine 1109
Cysteine 2037 and cysteine 2050
Cysteine 705 and cysteine 726
Cysteine 730 and cysteine 763
Cysteine 1332 and cysteine 1348
Cysteine 1465 and cysteine 1476
Cysteine 301 and cysteine 319
Cysteine 164 and cysteine 183
Cysteine 1182 and cysteine 1189
Cysteine 662 and cysteine 687
Cysteine 631 and cysteine 636
Cysteine 698 and cysteine 703
Cysteine 338 and cysteine 358
Cysteine 364 and cysteine 620
Cysteine 96 and cysteine 120
Cysteine 1899 and cysteine 1906
Cysteine 2007 and cysteine 2078
Cysteine 1127 and cysteine 1146
Cysteine 34 and cysteine 52
Cysteine 1731 and cysteine 1737
Cysteine 638 and cysteine 658
Cysteine 1610 and cysteine 1616
Cysteine 1052 and cysteine 1074
Cysteine 2266 and cysteine 2283
Cysteine 1546 and cysteine 1568
Cysteine 1250 and cysteine 1282
Cysteine 2002 and cysteine 2008
Cysteine 774 and cysteine 899
Cysteine 2593 and cysteine 2717
A redox-regulated disulphide may form within Thyroglobulin between cysteines 408 and 608.

Details

Redox score ?
90
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
408
Residue number B
608
Peptide name
Thyroglobulin

Ligandability

Cysteine 408 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 608 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1930 and 1941.

Details

Redox score ?
88
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1930
Residue number B
1941
Peptide name
Thyroglobulin

Ligandability

Cysteine 1930 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1941 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 901 and 922.

Details

Redox score ?
88
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
901
Residue number B
922
Peptide name
Thyroglobulin

Ligandability

Cysteine 901 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 922 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1479 and 1493.

Details

Redox score ?
88
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1479
Residue number B
1493
Peptide name
Thyroglobulin

Ligandability

Cysteine 1479 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1493 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1496 and 1513.

Details

Redox score ?
87
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1496
Residue number B
1513
Peptide name
Thyroglobulin

Ligandability

Cysteine 1496 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1513 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1517 and 1526.

Details

Redox score ?
86
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1517
Residue number B
1526
Peptide name
Thyroglobulin

Ligandability

Cysteine 1517 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1526 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1216 and 1265.

Details

Redox score ?
86
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1216
Residue number B
1265
Peptide name
Thyroglobulin

Ligandability

Cysteine 1216 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1265 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1150 and 1170.

Details

Redox score ?
86
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1150
Residue number B
1170
Peptide name
Thyroglobulin

Ligandability

Cysteine 1150 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1170 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1232 and 1246.

Details

Redox score ?
86
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1232
Residue number B
1246
Peptide name
Thyroglobulin

Ligandability

Cysteine 1232 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1246 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 926 and 1032.

Details

Redox score ?
86
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
926
Residue number B
1032
Peptide name
Thyroglobulin

Ligandability

Cysteine 926 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1032 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2136 and 2142.

Details

Redox score ?
86
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
2136
Residue number B
2142
Peptide name
Thyroglobulin

Ligandability

Cysteine 2136 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2142 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1078 and 1109.

Details

Redox score ?
85
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1078
Residue number B
1109
Peptide name
Thyroglobulin

Ligandability

Cysteine 1078 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1109 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2037 and 2050.

Details

Redox score ?
85
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
2037
Residue number B
2050
Peptide name
Thyroglobulin

Ligandability

Cysteine 2037 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2050 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 705 and 726.

Details

Redox score ?
85
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
705
Residue number B
726
Peptide name
Thyroglobulin

Ligandability

Cysteine 705 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 726 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 730 and 763.

Details

Redox score ?
85
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
730
Residue number B
763
Peptide name
Thyroglobulin

Ligandability

Cysteine 730 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 763 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1332 and 1348.

Details

Redox score ?
85
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1332
Residue number B
1348
Peptide name
Thyroglobulin

Ligandability

Cysteine 1332 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1348 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1465 and 1476.

Details

Redox score ?
85
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1465
Residue number B
1476
Peptide name
Thyroglobulin

Ligandability

Cysteine 1465 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1476 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 301 and 319.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
301
Residue number B
319
Peptide name
Thyroglobulin

Ligandability

Cysteine 301 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 319 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 164 and 183.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
164
Residue number B
183
Peptide name
Thyroglobulin

Ligandability

Cysteine 164 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 183 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1182 and 1189.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1182
Residue number B
1189
Peptide name
Thyroglobulin

Ligandability

Cysteine 1182 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1189 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 662 and 687.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
662
Residue number B
687
Peptide name
Thyroglobulin

Ligandability

Cysteine 662 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 687 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 631 and 636.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
631
Residue number B
636
Peptide name
Thyroglobulin

Ligandability

Cysteine 631 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 636 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 698 and 703.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
698
Residue number B
703
Peptide name
Thyroglobulin

Ligandability

Cysteine 698 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 703 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 338 and 358.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
338
Residue number B
358
Peptide name
Thyroglobulin

Ligandability

Cysteine 338 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 358 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 364 and 620.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
364
Residue number B
620
Peptide name
Thyroglobulin

Ligandability

Cysteine 364 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 620 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 96 and 120.

Details

Redox score ?
84
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
96
Residue number B
120
Peptide name
Thyroglobulin

Ligandability

Cysteine 96 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 120 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1899 and 1906.

Details

Redox score ?
83
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1899
Residue number B
1906
Peptide name
Thyroglobulin

Ligandability

Cysteine 1899 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1906 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2007 and 2078.

Details

Redox score ?
83
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
2007
Residue number B
2078
Peptide name
Thyroglobulin

Ligandability

Cysteine 2007 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2078 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1127 and 1146.

Details

Redox score ?
83
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1127
Residue number B
1146
Peptide name
Thyroglobulin

Ligandability

Cysteine 1127 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1146 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 34 and 52.

Details

Redox score ?
83
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
34
Residue number B
52
Peptide name
Thyroglobulin

Ligandability

Cysteine 34 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 52 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1731 and 1737.

Details

Redox score ?
83
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1731
Residue number B
1737
Peptide name
Thyroglobulin

Ligandability

Cysteine 1731 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1737 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 638 and 658.

Details

Redox score ?
83
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
638
Residue number B
658
Peptide name
Thyroglobulin

Ligandability

Cysteine 638 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 658 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1610 and 1616.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1610
Residue number B
1616
Peptide name
Thyroglobulin

Ligandability

Cysteine 1610 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1616 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1052 and 1074.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1052
Residue number B
1074
Peptide name
Thyroglobulin

Ligandability

Cysteine 1052 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1074 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2266 and 2283.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
2266
Residue number B
2283
Peptide name
Thyroglobulin

Ligandability

Cysteine 2266 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2283 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1546 and 1568.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1546
Residue number B
1568
Peptide name
Thyroglobulin

Ligandability

Cysteine 1546 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1568 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 1250 and 1282.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
1250
Residue number B
1282
Peptide name
Thyroglobulin

Ligandability

Cysteine 1250 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1282 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2002 and 2008.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
2002
Residue number B
2008
Peptide name
Thyroglobulin

Ligandability

Cysteine 2002 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2008 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 774 and 899.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
0
Peptide accession
A0A4W2CHS8
Residue number A
774
Residue number B
899
Peptide name
Thyroglobulin

Ligandability

Cysteine 774 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 899 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Thyroglobulin between cysteines 2593 and 2717.

Details

Redox score ?
82
PDB code
7n4y
Structure name
the structure of bovine thyroglobulin with iodinated tyrosines
Structure deposition date
2021-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A4W2CHS8
Residue number A
2593
Residue number B
2717
Peptide name
Thyroglobulin

Ligandability

Cysteine 2593 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2717 of Thyroglobulin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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