DNA-directed RNA polymerase subunit beta
Intermolecular
Cysteine 1430 of DNA-directed RNA polymerase subunit and cysteine 1232
Intramolecular
Cysteine 1199 and cysteine 1214
Cysteine 1196 and cysteine 1214
Cysteine 1196 and cysteine 1199
Cysteine 1199 and cysteine 1217
Cysteine 1214 and cysteine 1217
Cysteine 1196 and cysteine 1217
Cysteine 249 and cysteine 254
Cysteine 298 and cysteine 301
Cysteine 587 and cysteine 784
More...Cysteine 298 and cysteine 649
Cysteine 301 and cysteine 649
Cysteine 103 and cysteine 773
7ega o 1430 p 1155
A redox-regulated disulphide may form between cysteine 1430 of DNA-directed RNA polymerase subunit and cysteine 1232 of DNA-directed RNA polymerase subunit beta (1430 and 1155 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7ega
Structure name
tfiid-based intermediate pic on puma promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
100
Peptide A name
DNA-directed RNA polymerase subunit
Peptide B name
DNA-directed RNA polymerase subunit beta
Peptide A accession
A0A480TA59
Peptide B accession
A0A4X1TVZ5
Peptide A residue number
1430
Peptide B residue number
1232
Ligandability
Cysteine 1430 of DNA-directed RNA polymerase subunit
Cysteine 1232 of DNA-directed RNA polymerase subunit beta
7ega p 1122 p 1137
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1199 and 1214 (1122 and 1137 respectively in this structure).
Details
Redox score ?
85
PDB code
7ega
Structure name
tfiid-based intermediate pic on puma promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
3
% buried
56
Peptide accession
A0A4X1TVZ5
Residue number A
1199
Residue number B
1214
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1199 of DNA-directed RNA polymerase subunit beta
Cysteine 1214 of DNA-directed RNA polymerase subunit beta
7eg7 p 1119 p 1137
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1196 and 1214 (1119 and 1137 respectively in this structure).
Details
Redox score ?
81
PDB code
7eg7
Structure name
tfiid-based core pic on scp promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
38
Peptide accession
A0A4X1TVZ5
Residue number A
1196
Residue number B
1214
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1196 of DNA-directed RNA polymerase subunit beta
Cysteine 1214 of DNA-directed RNA polymerase subunit beta
7eg9 p 1119 p 1122
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1196 and 1199 (1119 and 1122 respectively in this structure).
Details
Redox score ?
79
PDB code
7eg9
Structure name
tfiid-based intermediate pic on scp promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
54
Peptide accession
A0A4X1TVZ5
Residue number A
1196
Residue number B
1199
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1196 of DNA-directed RNA polymerase subunit beta
Cysteine 1199 of DNA-directed RNA polymerase subunit beta
7eg9 p 1122 p 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1199 and 1217 (1122 and 1140 respectively in this structure).
Details
Redox score ?
78
PDB code
7eg9
Structure name
tfiid-based intermediate pic on scp promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
46
Peptide accession
A0A4X1TVZ5
Residue number A
1199
Residue number B
1217
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1199 of DNA-directed RNA polymerase subunit beta
Cysteine 1217 of DNA-directed RNA polymerase subunit beta
7ega p 1137 p 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1214 and 1217 (1137 and 1140 respectively in this structure).
Details
Redox score ?
75
PDB code
7ega
Structure name
tfiid-based intermediate pic on puma promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
36
Peptide accession
A0A4X1TVZ5
Residue number A
1214
Residue number B
1217
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1214 of DNA-directed RNA polymerase subunit beta
Cysteine 1217 of DNA-directed RNA polymerase subunit beta
7eg9 p 1119 p 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1196 and 1217 (1119 and 1140 respectively in this structure).
Details
Redox score ?
74
PDB code
7eg9
Structure name
tfiid-based intermediate pic on scp promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
5
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
34
Peptide accession
A0A4X1TVZ5
Residue number A
1196
Residue number B
1217
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1196 of DNA-directed RNA polymerase subunit beta
Cysteine 1217 of DNA-directed RNA polymerase subunit beta
7f4g B 172 B 177
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 249 and 254 (172 and 177 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7f4g
Structure name
structure of rpap2-bound rna polymerase ii
Structure deposition date
2021-06-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
72
Peptide accession
A0A4X1TVZ5
Residue number A
249
Residue number B
254
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 249 of DNA-directed RNA polymerase subunit beta
Cysteine 254 of DNA-directed RNA polymerase subunit beta
7eg8 p 221 p 224
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 298 and 301 (221 and 224 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7eg8
Structure name
tfiid-based core pic on puma promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
79
Peptide accession
A0A4X1TVZ5
Residue number A
298
Residue number B
301
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 298 of DNA-directed RNA polymerase subunit beta
Cysteine 301 of DNA-directed RNA polymerase subunit beta
7f4g B 510 B 707
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 587 and 784 (510 and 707 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7f4g
Structure name
structure of rpap2-bound rna polymerase ii
Structure deposition date
2021-06-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
95
Minimum pKa ?
12
% buried
100
Peptide accession
A0A4X1TVZ5
Residue number A
587
Residue number B
784
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 587 of DNA-directed RNA polymerase subunit beta
Cysteine 784 of DNA-directed RNA polymerase subunit beta
7eg9 p 221 p 572
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 298 and 649 (221 and 572 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7eg9
Structure name
tfiid-based intermediate pic on scp promoter
Structure deposition date
2021-03-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
90
Peptide accession
A0A4X1TVZ5
Residue number A
298
Residue number B
649
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 298 of DNA-directed RNA polymerase subunit beta
Cysteine 649 of DNA-directed RNA polymerase subunit beta
7edx p 224 p 572
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 301 and 649 (224 and 572 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
7edx
Structure name
p53-bound tfiid-based core pic on hdm2 promoter
Structure deposition date
2021-03-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
72
Peptide accession
A0A4X1TVZ5
Residue number A
301
Residue number B
649
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 301 of DNA-directed RNA polymerase subunit beta
Cysteine 649 of DNA-directed RNA polymerase subunit beta
7f4g B 26 B 696
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 103 and 773 (26 and 696 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
7f4g
Structure name
structure of rpap2-bound rna polymerase ii
Structure deposition date
2021-06-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
100
Peptide accession
A0A4X1TVZ5
Residue number A
103
Residue number B
773
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 103 of DNA-directed RNA polymerase subunit beta
Cysteine 773 of DNA-directed RNA polymerase subunit beta
If this tool was useful for finding a disulphide, please cite: