ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Intermolecular
Cysteine 155 and cysteine 151 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Cysteine 155 and cysteine 141 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Intramolecular
Cysteine 77 and cysteine 84
Cysteine 113 and cysteine 125
A redox-regulated disulphide may form between cysteine 155 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 and cysteine 151 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial (155 and 141 respectively in this structure).

Details

Redox score ?
71
PDB code
7vy1
Structure name
membrane arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
75
Minimum pKa ?
8
% buried
99
Peptide A name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Peptide B name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Peptide A accession
A0A4X1VYV0
Peptide B accession
A0A287BMW6
Peptide A residue number
155
Peptide B residue number
151

Ligandability

Cysteine 155 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 155 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 and cysteine 141 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial.

Details

Redox score ?
70
PDB code
7vy9
Structure name
membrane arm of active state ci from q10-nadh dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
7
% buried
100
Peptide A name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
Peptide B name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Peptide A accession
A0A4X1VYV0
Peptide B accession
A0A8D1EYI7
Peptide A residue number
155
Peptide B residue number
141

Ligandability

Cysteine 155 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 141 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 between cysteines 77 and 84.

Details

Redox score ?
81
PDB code
7w4j
Structure name
deactive state ci from q1-nadh dataset, subclass 1
Structure deposition date
2021-11-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
63
Peptide accession
A0A4X1VYV0
Residue number A
77
Residue number B
84
Peptide name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Ligandability

Cysteine 77 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 84 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 between cysteines 113 and 125.

Details

Redox score ?
72
PDB code
7w4e
Structure name
active state ci from q1-nadh dataset, subclass 3
Structure deposition date
2021-11-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
72
Minimum pKa ?
9
% buried
82
Peptide accession
A0A4X1VYV0
Residue number A
113
Residue number B
125
Peptide name
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Ligandability

Cysteine 113 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 125 of NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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