ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

T cell receptor beta variable 28

Intramolecular
Cysteine 42 and cysteine 110
Cysteine 42 and cysteine 7
A redox-regulated disulphide may form within T cell receptor beta variable 28 between cysteines 42 and 110 (23 and 91 respectively in this structure).

Details

Redox score ?
80
PDB code
6avf
Structure name
crystal structure of the kfj5 tcr-ny-eso-1-hla-b*07:02 complex
Structure deposition date
2017-09-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A5B6
Residue number A
42
Residue number B
110
Peptide name
T cell receptor beta variable 28

Ligandability

Cysteine 42 of T cell receptor beta variable 28

Cysteine 110 of T cell receptor beta variable 28

A redox-regulated disulphide may form within T cell receptor beta variable 28 between cysteines 42 and 7 (144 and 209 respectively in this structure).

Details

Redox score ?
nan
PDB code
6avf
Structure name
crystal structure of the kfj5 tcr-ny-eso-1-hla-b*07:02 complex
Structure deposition date
2017-09-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A5B6
Residue number A
42
Residue number B
7
Peptide name
T cell receptor beta variable 28

Ligandability

Cysteine 42 of T cell receptor beta variable 28

Cysteine 7 of T cell receptor beta variable 28

Uncertain whether structure cysteine 144 has been assigned to correct residue.
Uncertain whether structure cysteine 209 has been assigned to correct residue.
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