a tool for identifying drug-targetable redox-active disulphides

IG c1437_light_IGLV1-40_IGLJ1

Intramolecular

Cysteine 22 and cysteine 90

A redox-regulated disulphide may form within IG c1437_light_IGLV1-40_IGLJ1 between cysteines 22 and 90.

Details

Redox score ?

79

PDB code

Structure name

sars-cov-2 omicron variant spike in complex with three human neutralizing antibodies

Structure deposition date

2022-01-01

Thiol separation (Å)

2

Half-sphere exposure sum ?

91

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

22

Residue number B

90

Peptide name

IG c1437_light_IGLV1-40_IGLJ1

Ligandability

Cysteine 22 of IG c1437_light_IGLV1-40_IGLJ1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of IG c1437_light_IGLV1-40_IGLJ1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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