ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein 276

Intermolecular
Cysteine 196 and cysteine 196
Intramolecular
Cysteine 129 and cysteine 189
Cysteine 129 and cysteine 132
Cysteine 129 and cysteine 186
Cysteine 132 and cysteine 189
Cysteine 186 and cysteine 189
Cysteine 132 and cysteine 186
A redox-regulated disulphide may form between two units of Zinc finger protein 276 at cysteines 196 and 196 (71 and 71 respectively in this structure).

Details

Redox score ?
82
PDB code
7ppp
Structure name
crystal structure of zad-domain of znf_276 protein from rabbit
Structure deposition date
2021-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
Zinc finger protein 276
Peptide B name
Zinc finger protein 276
Peptide A accession
A0A5F9DAT3
Peptide B accession
A0A5F9DAT3
Peptide A residue number
196
Peptide B residue number
196

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 276 between cysteines 129 and 189 (4 and 64 respectively in this structure).

Details

Redox score ?
88
PDB code
7ppp
Structure name
crystal structure of zad-domain of znf_276 protein from rabbit
Structure deposition date
2021-09-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
52
Minimum pKa ?
6
% buried
nan
Peptide accession
A0A5F9DAT3
Residue number A
129
Residue number B
189
Peptide name
Zinc finger protein 276

Ligandability

Cysteine 129 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 276 between cysteines 129 and 132 (4 and 7 respectively in this structure).

Details

Redox score ?
85
PDB code
7ppp
Structure name
crystal structure of zad-domain of znf_276 protein from rabbit
Structure deposition date
2021-09-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
58
Minimum pKa ?
6
% buried
8
Peptide accession
A0A5F9DAT3
Residue number A
129
Residue number B
132
Peptide name
Zinc finger protein 276

Ligandability

Cysteine 129 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 132 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 276 between cysteines 129 and 186 (4 and 61 respectively in this structure).

Details

Redox score ?
83
PDB code
7ppp
Structure name
crystal structure of zad-domain of znf_276 protein from rabbit
Structure deposition date
2021-09-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
6
% buried
nan
Peptide accession
A0A5F9DAT3
Residue number A
129
Residue number B
186
Peptide name
Zinc finger protein 276

Ligandability

Cysteine 129 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 276 between cysteines 132 and 189 (7 and 64 respectively in this structure).

Details

Redox score ?
78
PDB code
7ppp
Structure name
crystal structure of zad-domain of znf_276 protein from rabbit
Structure deposition date
2021-09-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
58
Minimum pKa ?
8
% buried
24
Peptide accession
A0A5F9DAT3
Residue number A
132
Residue number B
189
Peptide name
Zinc finger protein 276

Ligandability

Cysteine 132 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 276 between cysteines 186 and 189 (61 and 64 respectively in this structure).

Details

Redox score ?
77
PDB code
7ppp
Structure name
crystal structure of zad-domain of znf_276 protein from rabbit
Structure deposition date
2021-09-14
Thiol separation (Å)
3
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
23
Peptide accession
A0A5F9DAT3
Residue number A
186
Residue number B
189
Peptide name
Zinc finger protein 276

Ligandability

Cysteine 186 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 276 between cysteines 132 and 186 (7 and 61 respectively in this structure).

Details

Redox score ?
77
PDB code
7ppp
Structure name
crystal structure of zad-domain of znf_276 protein from rabbit
Structure deposition date
2021-09-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
8
% buried
14
Peptide accession
A0A5F9DAT3
Residue number A
132
Residue number B
186
Peptide name
Zinc finger protein 276

Ligandability

Cysteine 132 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Zinc finger protein 276

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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