ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

MHC class II antigen

Intramolecular
Cysteine 149 and cysteine 205
Cysteine 47 and cysteine 111
A redox-regulated disulphide may form within MHC class II antigen between cysteines 149 and 205 (131 and 187 respectively in this structure).

Details

Redox score ?
80
PDB code
6xc9
Structure name
immune receptor complex
Structure deposition date
2020-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A6B9KAL0
Residue number A
149
Residue number B
205
Peptide name
MHC class II antigen

Ligandability

Cysteine 149 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II antigen between cysteines 47 and 111 (29 and 93 respectively in this structure).

Details

Redox score ?
79
PDB code
6xc9
Structure name
immune receptor complex
Structure deposition date
2020-06-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A6B9KAL0
Residue number A
47
Residue number B
111
Peptide name
MHC class II antigen

Ligandability

Cysteine 47 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 111 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: