ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ig heavy chain variable region

Intramolecular
Cysteine 22 and cysteine 95
Cysteine 47 and cysteine 106
A redox-regulated disulphide may form within Ig heavy chain variable region between cysteines 22 and 95.

Details

Redox score ?
80
PDB code
7eo0
Structure name
foot and mouth disease virus o/tibet/99-bound the single chain fragmen antibody c4
Structure deposition date
2021-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A6B9SE04
Residue number A
22
Residue number B
95
Peptide name
Ig heavy chain variable region

Ligandability

Cysteine 22 of Ig heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 95 of Ig heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig heavy chain variable region between cysteines 47 and 106.

Details

Redox score ?
79
PDB code
7eo0
Structure name
foot and mouth disease virus o/tibet/99-bound the single chain fragmen antibody c4
Structure deposition date
2021-04-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A6B9SE04
Residue number A
47
Residue number B
106
Peptide name
Ig heavy chain variable region

Ligandability

Cysteine 47 of Ig heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of Ig heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: