ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Solute carrier family 7 member 9

Intermolecular
Cysteine 144 and cysteine 114 of Glycosyl hydrolase family 13 catalytic domain-containing protein
Intramolecular
Cysteine 129 and cysteine 321
A redox-regulated disulphide may form between cysteine 144 of Solute carrier family 7 member 9 and cysteine 114 of Glycosyl hydrolase family 13 catalytic domain-containing protein.

Details

Redox score ?
82
PDB code
7nf6
Structure name
ovine b0,+at-rbat heterodimer
Structure deposition date
2021-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide A name
Solute carrier family 7 member 9
Peptide B name
Glycosyl hydrolase family 13 catalytic domain-containing protein
Peptide A accession
A0A6P3EL78
Peptide B accession
A0A6P7DVK7
Peptide A residue number
144
Peptide B residue number
114

Ligandability

Cysteine 144 of Solute carrier family 7 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Glycosyl hydrolase family 13 catalytic domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Solute carrier family 7 member 9 between cysteines 129 and 321. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7nf8
Structure name
ovine (b0,+at-rbat)2 hetero-tetramer, asymmetric unit, rigid-body fitted
Structure deposition date
2021-02-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
91
Minimum pKa ?
11
% buried
96
Peptide accession
A0A6P3EL78
Residue number A
129
Residue number B
321
Peptide name
Solute carrier family 7 member 9

Ligandability

Cysteine 129 of Solute carrier family 7 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 321 of Solute carrier family 7 member 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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